Classifications

• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
  • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
  • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
  • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
  • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L2300/00—Additional constructional details
  • B01L2300/08—Geometry, shape and general structure
  • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
  • B01L2300/0874—Three dimensional network
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L2300/00—Additional constructional details
  • B01L2300/08—Geometry, shape and general structure
  • B01L2300/0887—Laminated structure
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L2300/00—Additional constructional details
  • B01L2300/12—Specific details about materials
  • B01L2300/123—Flexible; Elastomeric
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L2400/00—Moving or stopping fluids
  • B01L2400/04—Moving fluids with specific forces or mechanical means
  • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
  • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L2400/00—Moving or stopping fluids
  • B01L2400/04—Moving fluids with specific forces or mechanical means
  • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
  • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
  • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
  • B01L2400/00—Moving or stopping fluids
  • B01L2400/06—Valves, specific forms thereof
  • B01L2400/0633—Valves, specific forms thereof with moving parts
  • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves

Definitions

• FLUID CARD COMPRISING AT LEAST ONE FLUID VALVE
• the present invention relates to the field of fluidic cards, allowing in particular the realization of in vitro diagnostics. It particularly concerns the field of fluidic valves present on these fluidic boards and the field of techniques relating to the control of such fluidic valves.
• the invention has applications in many industrial fields, such as among others the fields of medical research, biology, pharmaceuticals and the environment (air quality, threats, etc.).
• the invention thus proposes a fluidic card comprising a first fluidic support and a second fluidic medium between which a diaphragm is placed to form a fluidic valve, as well as a method for controlling at least one fluidic valve of such a fluidic card. and a corresponding manufacturing method.
• French Patent Application FR 3,006,207 A1 already discloses an example of a fluidic card comprising a fluidic channel formed in a rigid support, the fluidic card comprising a flexible film disposed on the surface of the rigid support at the level of which opens an opening. of the fluidic channel. The deformation of the flexible film between a closed position and an open position then makes it possible to prevent or allow fluid flow of the fluidic channel through the opening.
• This fluidic card is used with a card holder, adapted to allow deformation of the flexible film when the fluidic card is plated on it. More precisely, the deformation is obtained by means of a pressure fluid circulating in a fluidic channel for controlling the card support.
• the flexible film used may have a plastic deformation but not necessarily elastic, which may limit the possibility of vertical deflection.
• the use of the card support requires aligning external means to the geometry of the fluidic card. If there is a change in fluidic card geometry, the card holder must be reconfigured. In particular, the external actuation being placed directly under the fluidic valve, it is then necessary to modify the support if it is desired to move the valve.
• a fluidic device for performing chemical tests on which is performed a fluidic valve This is formed between an upper plate and a lower plate using a flexible diaphragm closing or opening the orifice of a fluid channel by pressurizing a port and a control chamber.
• the invention thus aims to at least partially remedy the needs mentioned above and the disadvantages relating to the achievements of the prior art.
• the invention aims in particular to provide an improved alternative solution for the design of a fluidic fluidic valve for a simplified control of its operation.
• the invention thus has, according to one of its aspects, a fluidic card, characterized in that it comprises: a first fluid support in which at least an inlet fluidic channel and an outlet fluidic channel are at least partially formed, and
• the fluidic card comprising a fluidic valve diaphragm positioned between the first and second fluidic supports, against a proximal surface of the first fluidic support and against a proximal surface of the second fluidic support, the fluidic inlet channel and the fluidic outlet channel opening on the proximal surface of the first fluidic support vis-à-vis the fluidic valve diaphragm, and the fluidic actuation channel opening on the proximal surface of the second fluidic support also vis-à-vis the diaphragm fluidic valve, to allow the formation of a fluidic valve,
• the fluidic actuation channel being subjected to pneumatic actuation means of the fluidic valve
• the fluidic valve diaphragm being adapted, under the action of the pneumatic actuating means of the fluidic valve, to be deformed between a closed position in which it prevents a flow of fluid between the inlet fluid channel and the fluidic channel of the fluidic valve; outlet, and an open position in which it allows the presence of a fluid flow space between the inlet fluid channel and the outlet fluid channel.
• proximal surface of the first fluidic support is placed in direct contact with at least a portion of the proximal surface of the second fluidic support.
• no material in particular a material used to act as a diaphragm or diaphragm, is placed between the two proximal surfaces of the first and second fluidic supports to take part in securing, in particular sealing, supports between them.
• a fluidic channel can lead to a surface directly, that is to say without intermediate element (in contact with the surface), or indirectly.
• a proximal surface when the channel opens into a developed intermediate space opening itself to the proximal surface.
• the fluidic card may also be called a microfluidic or consumable card.
• the assembly formed by the fluidic valve diaphragm disposed between the first and second fluidic supports constitutes a valve of the fluidic card.
• the deformation of the fluidic valve diaphragm between the open and closed positions allows the regulation of this valve.
• the valve of the fluidic card is therefore included therein, the assembly being consumable (i.e. disposable, after one or more uses depending on the application).
• the deformation of the fluidic valve diaphragm is under the action of the pneumatic actuating means to reach the closed position. This deformation is advantageously reversible to allow the fluidic valve diaphragm to return to the normally open position.
• the activation or control of the valve of the fluidic card can thus be done by pneumatic actuation and release on the diaphragm of the fluidic valve.
• proximal and distal are to be understood in relation to the positioning of an element relative to the fluidic valve (s) formed between the first and second fluidic supports.
• proximal surface of an element is the surface located closest to the fluidic valve or valves, while the distal surface of the element is the furthest surface from the fluidic valve or valves.
• the invention it is possible to obtain a fluidic valve design of a fluidic card and a principle for controlling the operation of such a fluidic valve with great reliability and simplicity. It may also be possible to produce fluidic valves on different levels (or different heights) of a fluidic card, and on the same level, to implement fluidic valves of different materials. Indeed, in the case for example where a method provides for the use of solvents and water, some materials are suitable for solvents while others are more suitable for water. Depending on the position on the microfluidic circuit, it would be possible to vary the diaphragm material to optimize chemical compatibility.
• the solution proposed by the invention can make it possible to integrate fluidic channels and pneumatic actuation channels on several levels of the fluidic card while simplifying the production and by grouping the air inlets and outlets for the actuation of the fluidic valves.
• the fluidic valve design proposed by the invention can provide great flexibility in the production of a fluidic card.
• the concept of fluidic card according to the invention can reduce the effort to be applied to the operation of the card, to obtain a better seal and a better resistance over time, to benefit from the great flexibility of materials used, their thickness and their diameter, among others.
• the proposed perpendicular positional positioning of the diaphragm to be gripped over the entire periphery may make it possible to avoid the aforementioned disadvantages of the prior art as regards sealing and volume modification problems.
• the fluidic card according to the invention may further comprise one or more of the following characteristics taken separately or in any possible technical combinations.
• the fluidic card may include a plurality of input and output fluidic channels together forming a fluid circuit of the card. Such fluidic channels may, all or at least some, lead to a fluidic valve diaphragm to form a fluidic card valve as in the invention.
• open position must be understood in a broad sense. Thus, it designates any position in which fluid can flow between the inlet fluid channel and the outlet fluid channel.
• the expression “open position” can therefore correspond to different degrees of opening, for example a half-opening position, that is to say a median deformation of the fluidic valve diaphragm or else a median pressure exerted on the diaphragm of a fluidic valve, or a position of total opening, that is to say a zero deformation of the diaphragm of the fluidic valve or a lack of pressure exerted on the valve diaphragm fluidics.
• the total open position allows maximum fluid flow between the inlet fluidic channel and the outlet fluidic channel.
• the normally open position In the case of a normally open configuration, the rest position allows the fluid to flow without external energy input. The closing of the valve is effected by the application of a pressure. In the case of a normally closed configuration, the rest position prevents the fluid from flowing. It is possible to exert an external pressure to maintain the tightness in case of excessive fluid pressure.
• the opening of the fluidic valve is then performed by depression. The opening degree of the open position can be adjusted depending on the deformability (ie pressure, or vacuum) applied to the fluidic valve diaphragm.
• the displacement of the fluidic valve diaphragm can be minute.
• the diaphragm of the fluidic valve can move by a distance less than or equal to 100 ⁇ .
• the fluidic valve diaphragm may be made of elastomeric material, especially chosen from: ethylene-propylene-diene monomers (EPDM), fluorinated elastomers (FKM), perfluorinated elastomers (FFKM), butadiene-acrylonitrile copolymers (NBR), among others.
• EPDM ethylene-propylene-diene monomers
• FKM fluorinated elastomers
• FFKM perfluorinated elastomers
• NBR butadiene-acrylonitrile copolymers
• first and second fluidic supports can be fixed together by sealing, in particular heat-sealing (for example, thermocompression, assisted or not by plasma or solvent treatment), ultrasonic sealing or laser sealing, and / or fixed together by bonding.
• the glue being in particular applied by screen printing or pad printing, or by the use of a double-sided adhesive, or by mechanical clamping, among others.
• the diaphragm of the fluidic valve does not intervene in the fixing operation, in particular of sealing, fluidic supports therebetween. On the contrary, it is compressed or pinched between the fluidic supports during sealing.
• the fixing between the first and second fluidic supports is carried out over the entire periphery of the fluidic valve diaphragm, in particular by direct contact of the proximal surfaces of the fluidic supports around the periphery of the fluidic valve diaphragm, so as to favor the sealing of the fluidic valve. Maintaining the fluidic valve diaphragm can therefore be symmetrical.
• first fluidic support may comprise a first at least partial insertion of the diaphragm of the fluidic valve, opening on the proximal surface of the first fluidic support, and / or the second fluidic may comprise a second insertion counterbore at least partial of the fluidic valve diaphragm, opening on the proximal surface of the second fluidic support.
• the presence of one or more insert counters on the fluidic card can simplify the placement of the fluidic valve diaphragm, and thus simplify the manufacture of the fluidic card.
• the fluidic valve diaphragm may be placed in one or more insertion counters, in particular two (one on each fluidic support), before joining the first and second fluidic supports together.
• each insertion counterbore has a thickness that is smaller than the thickness of the fluidic valve diaphragm that it is intended to receive.
• one of the first and second fluidic supports may comprise an insertion counterbore in which the fluidic valve diaphragm is inserted, the other of the first and second fluidic supports being free of insertion counterbore. and then being pressed against the fluidic valve diaphragm to form the fluidic valve.
• each fluidic support comprises an insertion half-counter in which the fluidic valve diaphragm is inserted, the first and second fluidic supports then being pressed against each other.
• the first insertion counterbore and / or the second insertion counterbore may have a larger dimension, in particular a diameter of between 1 and 10 mm, in particular between 3 and 4 mm.
• the fluidic actuation channel may have a diameter of the order of a few millimeters.
• the inlet fluidic channel and / or the fluidic outlet channel may open onto the proximal surface of the first fluidic support vis-à-vis the fluidic valve diaphragm, centrally with respect to the fluidic valve diaphragm.
• the fluidic card may have a reversible operation
• the input fluid channel may also serve as an output fluid channel while the output fluid channel may serve as an input fluid channel.
• inlet fluidic channel and the outlet fluidic channel may, on the proximal surface of the first fluidic support, be substantially orthogonal to the direction of extension of the first fluidic support along its largest dimension.
• the fluidic actuation channel may open, on the proximal surface of the second fluidic support, substantially orthogonal to the extension direction of the second fluidic support according to its largest dimension.
• having input, output and / or actuating fluidic channels substantially perpendicular to the fluidic valve diaphragm may further enhance the sealing of the fluidic valve.
• the first fluidic support may also comprise a fluidic groove, for example annular, opening on the proximal surface of the first fluidic support vis-à-vis the fluidic valve diaphragm, and in which at least one of the inlet fluidic channels and exit leads.
• the fluidic groove may in particular be formed all around one of the inlet and outlet fluid channels, the latter being in particular centered with respect to the fluidic valve diaphragm.
• the inlet fluidic channel and the outlet fluidic channel may lead to a fluidic opening, itself open to the proximal surface of the first fluidic support vis-à-vis the fluidic valve diaphragm.
• This fluidic opening preferably extends along its largest dimension substantially parallel to the fluidic valve diaphragm.
• the diaphragm of the fluidic valve may have a thickness between 100 and 500 ⁇ , in particular between 300 and 400 ⁇ .
• the thickness of the fluidic valve diaphragm can be adapted according to the parameters applied, such as for example the pressure or the volume of fluid.
• the first fluid carrier and / or the second fluid carrier may also be made of a material chosen from: copolymers of cycloolefins (COC), polymethyl methacrylate (PMMA), polymers of cycloolefins (COP), polycarbonate (PC ), among others.
• COC cycloolefins
• PMMA polymethyl methacrylate
• COP polymers of cycloolefins
• PC polycarbonate
• the fluidic card may comprise at least three superimposed fluidic supports and two by two directly joined to each other, see at least four, or even at least five or even more than five, at least one fluidic valve diaphragm which may or may not be systematically positioned between two adjacent fluidic supports to form at least one corresponding fluidic valve.
• the fluidic card may for example comprise between 2 and 5 superimposed fluidic supports and two by two directly secured to each other.
• the fluidic card can be connected to at least one instrument, in particular for carrying out in vitro diagnostics, such as, for example, a measuring device, a heating element, a mechanical actuator or a pump.
• a measuring device such as, for example, a measuring device, a heating element, a mechanical actuator or a pump.
• the map fluidic according to the invention may for example be used in association with a connection device as described in the international application WO 2012/136943 A1.
• the fluidic card may comprise complex functions, fluidic or not, for example a biochip or a reaction chamber.
• the fluidic card may have dimensions similar or similar to the dimensions of a credit card. Its thickness may be sufficient to contain at least one inlet fluid channel, an outlet fluid channel and an actuating fluid channel, and possibly a fluidic network (having a plurality of fluidic channels).
• the length and / or the width of the fluidic card may be between a few centimeters and a few decimetres, for example between 1 cm and 10 cm, or even 20 cm.
• the thickness of the fluidic card may be between a few millimeters and a few centimeters, for example between, on the one hand, 1 mm or 5 mm and, on the other hand, 1 cm or 2 cm.
• the thickness of the fluidic card may be less than one millimeter, for example about 500 ⁇ .
• Another object of the invention is, according to another of its aspects, a method for controlling at least one fluidic valve of a fluidic card as defined above, in which the piloting of said at least one fluidic valve is carried out by varying the pressure of a fluid, for example air, flowing in the fluidic actuation channel which comes into contact with the fluidic valve diaphragm to allow deformation thereof.
• a fluid for example air
• the subject of the invention is also a method for manufacturing at least one fluidic valve of a fluidic card as defined above, characterized in that it comprises the following successive steps:
• the fluidic actuation channel or channels being opposite the one or more fluidic valve diaphragms, and the fluidic valve diaphragm (s) being compressed between the first and second fluidic supports,
• the fluidic card, the control method and the manufacturing method according to the invention may comprise any of the previously mentioned characteristics, taken separately or in any technically possible combination with other characteristics.
• FIG. 1 represents, in section, an example of a fluidic card according to the invention
• FIG. 2 represents, in section, another example of a fluidic card according to the invention.
• FIG. 3 represents, in perspective, the fluidic card of FIG. 2.
• FIG. 1 shows, in section, a first example of a fluidic card 10 according to the invention.
• first fluid support 1 and a second fluidic support 2, superimposed and contiguous to one another.
• an upper outer layer 14 and a lower outer layer 15 are positioned on either side of the first 1 and second 2 fluidic supports, as also shown in Figures 2 and 3 described below, in order to close the channels. fluidic on their distal faces.
• These upper 14 and lower 15 outer layers may be constituted by other fluidic supports or else by films made of polymeric material, in particular having a thickness ranging from at least 50 to at least 150 ⁇ .
• the first 1 and second 2 fluidic supports are in particular fixed to one another by thermal sealing according to a thermocompression principle.
• thermal sealing according to a thermocompression principle.
• other types of fastening means are possible.
• the respective proximal surfaces 1a and 2a of the first 1 and second 2 fluidic supports are in direct contact with each other, the diaphragm 6 not involved during sealing.
• the first fluidic support 1 constitutes an upper stage SI, in which an input fluidic channel 3 is formed, allowing the entry of a fluid into the fluidic card 10, and an output fluidic channel. 4, allowing the exit of the fluid outside the fluidic card 10.
• the second fluidic support 2 constitutes a lower stage S2 in which an actuating fluidic channel 5 is formed.
• first fluidic support 1 has a distal surface 1b and a proximal surface 1a.
• second fluidic support 2 has a distal surface 2b and a proximal surface 2a.
• the fluidic card 10 thus comprises a diaphragm 6 positioned between the first 1 and second 2 fluidic supports, against the proximal surface 1a of the first fluidic support 1 and against the proximal surface 2a of the second fluidic support 2. , the diaphragm 6 is clamped between the first 1 and second 2 fluidic supports.
• the inlet fluidic channel 3 and the outlet fluidic channel 4 open out onto the proximal surface 1a of the first fluidic support 1 opposite the diaphragm 6. More particularly, the inlet fluidic channel 3 opens on the proximal surface 1a of the first fluidic support 1 centrally with respect to the diaphragm 6. Thus, a better seal is obtained by optimizing the support of the diaphragm 6.
• the fluidic actuation channel 5 opens on the proximal surface 2a of the second fluid support 2 also vis-a-vis the diaphragm 6, substantially orthogonal to the extension direction of the second fluidic support 2 according to its largest dimension , ie orthogonal to the proximal surface 2a of the second fluidic support 2.
• the fact of providing channels 3, 4, 5 opening perpendicularly to the diaphragm 6 further enhances the sealing of the fluidic valve 7.
• the fluidic actuation channel 5 is advantageously subjected to pneumatic actuation means of the fluidic valve 7, which may consist of a pneumatic supply to enable the control of the fluidic valve 7. More specifically, the fluidic actuation channel 5 may comprise a pressure fluid, in particular a pressure gas, for deforming the diaphragm 6 of the fluidic card 10.
• the operation of the fluidic valve 7 can be achieved by means of a pressure or a depression formed in the second fluidic support 2.
• the sending of a gas under pressure into the fluidic actuating channel 5 to make contact with the diaphragm 6 makes it possible to control the fluidic valve 7, and allows, by varying the intensity of the pressure exerted by the gas on the diaphragm 6, the passage of an open position, in which the diaphragm 6 allows the presence of a fluid flow space between the inlet fluidic channel 3 and the outlet fluidic channel 4, at the closed position of the diaphragm 6, in which it prevents a flow of fluid between the inlet fluid channel 3 and the outlet fluid channel 4, and vice versa.
• the method of controlling the fluidic valve 7 with the aid of the actuating means consists in varying the pressure of the gas which circulates in the fluidic actuating channel 5 of the second fluidic support 2, this gas coming into contact with the diaphragm 6 so as to allow the deformation of the diaphragm 6 and the closure or a variation of the degree of opening for the flow between the inlet fluid channel 3 and the outlet fluidic channel 4.
• the inlet fluidic channel 3 and the outlet fluidic channel 4 open onto a fluidic opening 8 extending parallel to the diaphragm 6, which in turn opens out onto the proximal surface. 1 of the first fluidic support 1 vis-à-vis the diaphragm 6.
• This fluidic opening 8 is essential in a normally open position to allow the flow of fluid between the inlet fluid channel 3 and the outlet fluidic channel 4.
• the depth of the annular groove (possible in normally open or normally closed) can vary from 0 to a few hundred micrometers, for example 300 ⁇ maximum, depending on the constraints of use of the fluidic card, such as pressure drop, dead volume, etc.
• the width of this groove is at least equal to the diameter of the outlet fluidic channel 4.
• the presence of such an insertion counter 9 makes it possible to simplify the placement of the diaphragm 6, and thus to simplify the manufacture of the fluidic card 10.
• the insertion counter 9 has a thickness that is smaller than the thickness of the diaphragm 6
• the insert counterbore 9 is also used for pinching and also makes it possible to limit flow leakage on the sides.
• the insertion counterbore 9 is in the form of a round, with a diameter of between 1 and 10 mm, in particular between 3 and 4 mm.
• FIGS. 2 and 3 respectively in section and in perspective, show a second example of a fluidic card 10 according to the invention.
• the fluidic card 10 here comprises three superimposed and two by two fluidic supports directly secured to each other, namely a first fluidic support 1, a second fluidic support 2 and a third fluidic support 13.
• the first fluidic support 1 is directly secured to the second fluidic support 2, which is directly secured to the third fluid support 13.
• the three fluidic supports 1, 2 and 13 are taken between two outer layers, namely an upper outer layer 14 and a lower outer layer 15.
• the first fluidic support 1 constitutes an upper stage SI in which a second input channel 3b and a second output channel 4b are formed.
• the second fluidic support 2 constitutes an intermediate stage S2 in which a first input channel 3a and a first output channel 4a are formed, a third input channel 3c and a third output channel 4c.
• a second actuating fluid channel 5b is also partially formed therein.
• the third fluid support 13 constitutes a lower stage S13 in which are formed a first actuating fluid channel 5a, a third actuating fluid channel 5c and the second actuating fluid channel 5b partially.
• first 6a, second 6b and third 6c diaphragms are located respectively between the first input channel 3a and the first output channel 4a and the first actuation fluid channel 5a, between the second input channel 3b and the second output channel 4b and the second actuation fluid channel 5b, and between the third input channel 3c and the third output channel 4c and the third actuation channel 5c, as shown.
• a fluidic card 10 is formed in which are formed three fluidic valves at different levels, namely a first fluidic valve 7a, a second fluidic valve 7b and a third fluidic valve 7c.
• valves 7a and 7b are in the same material, the diaphragm 6c is illustrated in a different material).
• the second fluidic support 2 and the third fluidic support 13 comprise insert counters 9, as described above with reference to the Figure 1 for the first embodiment. These insert counters 9 correspond more precisely to bores formed in the fluidic supports 2 and 13.
• first fluidic support 1 and the second fluidic support 2 comprise fluidic annular grooves 11 in which the fluidic outlet channels 4a, 4b and 4c open out. More particularly, these fluidic annular grooves 11 are formed all around the inlet fluidic channels 3a, 3b and 3c, which are centered relative to the diaphragm 6 corresponding thereto. Alternatively, in another embodiment of the invention, such fluidic grooves 11 may not be annular.
• the diaphragms 6 are deformed under the effect of the nip between two fluidic supports.
• a fluidic card 10 may comprise a number n of fluidic supports constituting n levels of the fluidic card 10.
• the fluidic input and output channels can then be formed in the fluidic support of level n and the fluidic actuation channel may be formed in the n-1 level fluidic support, or vice versa.
• the diaphragm 6 may have a thickness E, represented in FIG. 1, for example between 100 and 400 ⁇ , in particular between 300 and 400 ⁇ .
• the first fluid support 1 and / or the second fluid support 2 and / or the third fluid support 13 may be made of a material chosen from: cycloolefin copolymers (COC), polymethyl methacrylate (PMMA), polymers of cycloolefins (COP), polycarbonate (PC), among others.
• the diaphragm 6 is in all the examples made of elastomeric material, in particular chosen from: ethylene-propylene-diene monomers (EPDM), fluorinated elastomers (FKM), perfluorinated elastomers (FFKM), butadiene-acrylonitrile copolymers (NBR), among others. It is thus possible to overcome the rigidity of a polymer film by the choice of using the elasticity of an elastomeric film.
• EPDM ethylene-propylene-diene monomers
• FKM fluorinated elastomers
• FFKM perfluorinated elastomers
• NBR butadiene-acrylonitrile copolymers
• the fluidic valves 7, 7a, 7b and 7c can be configured in a normally open or normally closed operating mode. In normally open mode, a pressure must be applied to reach the closed position, whereas in normally closed mode a vacuum must be applied to deform the diaphragm 6 and reach an open position. In addition, in operation, depending on the pressure of the fluids flowing in the fluidic inlet and outlet channels, it may be necessary to apply an overpressure to reach the closed position.
• the pneumatic actuating fluid channel 5 is formed in a second lower fluidic support 2 while the inlet 3 and outlet 4 fluidic channels are formed in a first first fluid support 1.
• This choice is in no way limitative, the configuration being able to be notably inverted so that the pneumatic actuator fluid channel 5 is formed in a higher fluidic support 1 and the fluidic inlet 3 and outlet 4 channels are formed in a lower fluidic support 2.

Landscapes

• Chemical & Material Sciences (AREA)
• Health & Medical Sciences (AREA)
• Dispersion Chemistry (AREA)
• Analytical Chemistry (AREA)
• General Health & Medical Sciences (AREA)
• Hematology (AREA)
• Clinical Laboratory Science (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Fluid-Driven Valves (AREA)

Applications Claiming Priority (2)

Publications (1)

Family

ID=55129976

Family Applications (1)

Country Status (3)

Family Cites Families (11)

• 2015
  • 2015-08-20 FR FR1557826A patent/FR3040141B1/fr active Active
• 2016
  • 2016-08-18 EP EP16757604.0A patent/EP3337613A1/de not_active Withdrawn
  • 2016-08-18 WO PCT/EP2016/069570 patent/WO2017029348A1/fr unknown

Also Published As

Similar Documents

Legal Events