EP3270154A4 - Procédé de détection d'un anticorps monoclonal par spectrométrie de masse - Google Patents
Procédé de détection d'un anticorps monoclonal par spectrométrie de masse Download PDFInfo
- Publication number
- EP3270154A4 EP3270154A4 EP15884708.7A EP15884708A EP3270154A4 EP 3270154 A4 EP3270154 A4 EP 3270154A4 EP 15884708 A EP15884708 A EP 15884708A EP 3270154 A4 EP3270154 A4 EP 3270154A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- monoclonal antibody
- mass spectrometry
- detecting monoclonal
- detecting
- spectrometry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
- G01N27/623—Ion mobility spectrometry combined with mass spectrometry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8818—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015046059 | 2015-03-09 | ||
PCT/JP2015/085445 WO2016143224A1 (fr) | 2015-03-09 | 2015-12-18 | Procédé de détection d'un anticorps monoclonal par spectrométrie de masse |
Publications (3)
Publication Number | Publication Date |
---|---|
EP3270154A1 EP3270154A1 (fr) | 2018-01-17 |
EP3270154A4 true EP3270154A4 (fr) | 2019-01-09 |
EP3270154B1 EP3270154B1 (fr) | 2020-03-04 |
Family
ID=56879419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP15884708.7A Active EP3270154B1 (fr) | 2015-03-09 | 2015-12-18 | Procédé de détection d'un anticorps monoclonal par spectrométrie de masse |
Country Status (8)
Country | Link |
---|---|
US (1) | US10338039B2 (fr) |
EP (1) | EP3270154B1 (fr) |
JP (1) | JP6428911B2 (fr) |
KR (1) | KR102000862B1 (fr) |
CN (1) | CN107407666A (fr) |
BR (1) | BR112017017854A2 (fr) |
SG (1) | SG11201707318PA (fr) |
WO (1) | WO2016143224A1 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3023777B1 (fr) * | 2013-09-09 | 2017-11-15 | Shimadzu Corporation | Procédés de préparation de fragments peptidiques, kit de préparation de fragments peptidiques destiné à être utilisé dans celui-ci, et procédé d'analyse |
AU2015240454B2 (en) | 2014-04-04 | 2019-08-22 | Mayo Foundation For Medical Education And Research | Isotyping immunoglobulins using accurate molecular mass |
EP3353200A4 (fr) | 2015-09-24 | 2019-06-26 | Mayo Foundation for Medical Education and Research | Identification de chaînes légères dépourvues d'immunoglobuline par spectrométrie de masse |
AU2017325022B2 (en) | 2016-09-07 | 2022-10-13 | Mayo Foundation For Medical Education And Research | Identification and monitoring of cleaved immunoglobulins by molecular mass |
WO2018235228A1 (fr) * | 2017-06-22 | 2018-12-27 | 株式会社島津製作所 | Procédé de quantification d'un anticorps monoclonal auquel un antigène ou un anti-anticorps est lié |
US11946937B2 (en) | 2017-09-13 | 2024-04-02 | Mayo Foundation For Medical Education And Research | Identification and monitoring of apoptosis inhibitor of macrophage |
US11209392B2 (en) * | 2017-12-28 | 2021-12-28 | Shimadzu Corporation | Simplified monoclonal antibody quantification method |
BR112020013325A2 (pt) * | 2018-01-12 | 2020-12-01 | Genzyme Corporation | métodos para quantificação de polipeptídeos |
JP7056675B2 (ja) * | 2018-02-08 | 2022-04-19 | 株式会社島津製作所 | モノクローナル抗体の検出結果を向上する方法 |
JP7215467B2 (ja) * | 2019-08-19 | 2023-01-31 | 株式会社島津製作所 | ホルマリン固定パラフィン包埋組織試料からの抗体の分離、検出及び/又は分析方法 |
CN110608981A (zh) * | 2019-09-09 | 2019-12-24 | 中国科学院高能物理研究所 | 一种测定植物中硫化汞纳米颗粒的方法 |
CN111024862B (zh) * | 2019-12-31 | 2022-09-13 | 上海博威生物医药有限公司 | 一种奥马珠单抗疏水性的检测方法 |
CN111735869A (zh) * | 2020-05-29 | 2020-10-02 | 中山大学 | 一种蛋白质的检测试剂及检测方法 |
JPWO2022270126A1 (fr) | 2021-06-23 | 2022-12-29 | ||
CN113804804A (zh) * | 2021-09-08 | 2021-12-17 | 杭州佰辰医学检验所有限公司 | 一种超高效液相色谱串联质谱法快速测定血浆中单克隆抗体药物的监测方法 |
CN113899894B (zh) * | 2021-09-14 | 2023-11-14 | 上海中科新生命生物科技有限公司 | 一种同时检测贝伐珠单抗和曲妥珠单抗药物浓度的方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2481420A1 (fr) * | 2002-04-05 | 2003-10-23 | University Of Georgia Research Foundation | Procede de clivage et de deglycosylation d'anticorps pour promouvoir une liaison de ligand |
DE102004021351A1 (de) * | 2004-04-23 | 2005-11-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Funktionalisierter poröser Träger für Mikroarrays |
NZ560543A (en) * | 2005-01-28 | 2012-01-12 | Galenbio Inc | Immunologically active compositions using pathogen associated molecular patterns (PAMP) |
EP2617816B1 (fr) * | 2006-09-21 | 2015-11-18 | BASF Enzymes LLC | Phytases, acides nucléiques encodant celles-ci et méthodes pour leur fabrication et leur utilisation |
EP2097756B1 (fr) | 2006-12-21 | 2011-10-19 | Novartis AG | Analyse quantitative d'anticorps |
JP2012197258A (ja) | 2011-03-23 | 2012-10-18 | Tohoku Univ | 個別化治療診断のためのマーカータンパク質絶対量の定量方法 |
US8679767B2 (en) | 2011-05-12 | 2014-03-25 | Genentech, Inc. | Multiple reaction monitoring LC-MS/MS method to detect therapeutic antibodies in animal samples using framework signature peptides |
JP6148540B2 (ja) * | 2013-06-07 | 2017-06-14 | 株式会社島津製作所 | 質量分析装置を用いたグラニュリンペプチドの定量分析方法、および分析用プログラム |
EP3023777B1 (fr) * | 2013-09-09 | 2017-11-15 | Shimadzu Corporation | Procédés de préparation de fragments peptidiques, kit de préparation de fragments peptidiques destiné à être utilisé dans celui-ci, et procédé d'analyse |
CN115932065A (zh) * | 2015-03-10 | 2023-04-07 | 株式会社岛津制作所 | 用于检测单克隆抗体的样品调制用试剂盒 |
ES2815224T3 (es) * | 2015-11-06 | 2021-03-29 | Promise Proteomics | Un método para cuantificar anticuerpos terapéuticos |
-
2015
- 2015-12-18 JP JP2017504578A patent/JP6428911B2/ja not_active Expired - Fee Related
- 2015-12-18 KR KR1020177027416A patent/KR102000862B1/ko active IP Right Grant
- 2015-12-18 US US15/556,018 patent/US10338039B2/en not_active Expired - Fee Related
- 2015-12-18 EP EP15884708.7A patent/EP3270154B1/fr active Active
- 2015-12-18 BR BR112017017854-0A patent/BR112017017854A2/pt not_active Application Discontinuation
- 2015-12-18 CN CN201580077607.2A patent/CN107407666A/zh active Pending
- 2015-12-18 WO PCT/JP2015/085445 patent/WO2016143224A1/fr active Application Filing
- 2015-12-18 SG SG11201707318PA patent/SG11201707318PA/en unknown
Non-Patent Citations (3)
Title |
---|
QIAN ZHANG ET AL: "Generic Automated Method for Liquid Chromatography-Multiple Reaction Monitoring Mass Spectrometry Based Monoclonal Antibody Quantitation for Preclinical Pharmacokinetic Studies", ANALYTICAL CHEMISTRY, vol. 86, no. 17, 2 September 2014 (2014-09-02), US, pages 8776 - 8784, XP055252059, ISSN: 0003-2700, DOI: 10.1021/ac5019827 * |
R. W. KONDRAT ET AL: "Multiple reaction monitoring in mass spectrometry/mass spectrometry for direct analysis of complex mixtures", ANALYTICAL CHEMISTRY, vol. 50, no. 14, 1 December 1978 (1978-12-01), US, pages 2017 - 2021, XP055524599, ISSN: 0003-2700, DOI: 10.1021/ac50036a020 * |
See also references of WO2016143224A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP3270154A1 (fr) | 2018-01-17 |
CN107407666A (zh) | 2017-11-28 |
JP6428911B2 (ja) | 2018-11-28 |
US10338039B2 (en) | 2019-07-02 |
WO2016143224A1 (fr) | 2016-09-15 |
EP3270154B1 (fr) | 2020-03-04 |
KR102000862B1 (ko) | 2019-07-16 |
BR112017017854A2 (pt) | 2018-04-10 |
KR20170121265A (ko) | 2017-11-01 |
JPWO2016143224A1 (ja) | 2017-12-28 |
US20180059074A1 (en) | 2018-03-01 |
SG11201707318PA (en) | 2017-10-30 |
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