SG11201707318PA - Method for detecting monoclonal antibody using mass spectrometry - Google Patents

Method for detecting monoclonal antibody using mass spectrometry

Info

Publication number
SG11201707318PA
SG11201707318PA SG11201707318PA SG11201707318PA SG11201707318PA SG 11201707318P A SG11201707318P A SG 11201707318PA SG 11201707318P A SG11201707318P A SG 11201707318PA SG 11201707318P A SG11201707318P A SG 11201707318PA SG 11201707318P A SG11201707318P A SG 11201707318PA
Authority
SG
Singapore
Prior art keywords
monoclonal antibody
mass spectrometry
detecting monoclonal
detecting
spectrometry
Prior art date
Application number
SG11201707318PA
Inventor
Takashi Shimada
Noriko Iwamoto
Original Assignee
Shimadzu Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shimadzu Corp filed Critical Shimadzu Corp
Publication of SG11201707318PA publication Critical patent/SG11201707318PA/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/623—Ion mobility spectrometry combined with mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/6857—Antibody fragments
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8818—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
SG11201707318PA 2015-03-09 2015-12-18 Method for detecting monoclonal antibody using mass spectrometry SG11201707318PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015046059 2015-03-09
PCT/JP2015/085445 WO2016143224A1 (en) 2015-03-09 2015-12-18 Method for detecting monoclonal antibody using mass spectrometry

Publications (1)

Publication Number Publication Date
SG11201707318PA true SG11201707318PA (en) 2017-10-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201707318PA SG11201707318PA (en) 2015-03-09 2015-12-18 Method for detecting monoclonal antibody using mass spectrometry

Country Status (8)

Country Link
US (1) US10338039B2 (en)
EP (1) EP3270154B1 (en)
JP (1) JP6428911B2 (en)
KR (1) KR102000862B1 (en)
CN (1) CN107407666A (en)
BR (1) BR112017017854A2 (en)
SG (1) SG11201707318PA (en)
WO (1) WO2016143224A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015033479A1 (en) * 2013-09-09 2015-03-12 株式会社島津製作所 Method for preparing peptide fragments, kit for preparing peptide fragments to be used therein, and analysis method
WO2015154052A1 (en) 2014-04-04 2015-10-08 Mayo Foundation For Medical Education And Research Isotyping immunoglobulins using accurate molecular mass
WO2017053932A1 (en) 2015-09-24 2017-03-30 Mayo Foundation For Medical Education And Research Identification of immunoglobulin free light chains by mass spectrometry
AU2017325022B2 (en) 2016-09-07 2022-10-13 Mayo Foundation For Medical Education And Research Identification and monitoring of cleaved immunoglobulins by molecular mass
US11619616B2 (en) 2017-06-22 2023-04-04 Shimadzu Corporation Method for quantifying monoclonal antibody having antigen or anti-antibody bonded thereto
EP3681528A4 (en) 2017-09-13 2021-07-21 Mayo Foundation for Medical Education and Research Identification and monitoring of apoptosis inhibitor of macrophage
JP6835260B2 (en) 2017-12-28 2021-02-24 株式会社島津製作所 Simplified quantification method for monoclonal antibodies
EP3737949A1 (en) * 2018-01-12 2020-11-18 Genzyme Corporation Methods for the quantitation of polypeptides
WO2019155576A1 (en) * 2018-02-08 2019-08-15 株式会社島津製作所 Method for improving result of monoclonal antibody detection
JP7215467B2 (en) * 2019-08-19 2023-01-31 株式会社島津製作所 Method for separating, detecting and/or analyzing antibodies from formalin-fixed, paraffin-embedded tissue samples
CN110608981A (en) * 2019-09-09 2019-12-24 中国科学院高能物理研究所 Method for measuring mercury sulfide nanoparticles in plants
CN111024862B (en) * 2019-12-31 2022-09-13 上海博威生物医药有限公司 Method for detecting hydrophobicity of omalizumab
CN111735869A (en) * 2020-05-29 2020-10-02 中山大学 Protein detection reagent and detection method
CN117581103A (en) 2021-06-23 2024-02-20 株式会社岛津制作所 Method for analyzing antibodies
CN113804804A (en) * 2021-09-08 2021-12-17 杭州佰辰医学检验所有限公司 Monitoring method for rapidly determining monoclonal antibody drug in plasma by ultra-high performance liquid chromatography tandem mass spectrometry
CN113899894B (en) * 2021-09-14 2023-11-14 上海中科新生命生物科技有限公司 Method for simultaneously detecting drug concentration of bevacizumab and trastuzumab

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003087821A2 (en) * 2002-04-05 2003-10-23 University Of Georgia Research Foundation Method for cleaving and deglycosylating antibodies to promote ligand binding
DE102004021351A1 (en) * 2004-04-23 2005-11-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Functionalized porous carrier for microarrays
MX2007009177A (en) * 2005-01-28 2008-03-10 Galen Bio Inc Immunologically active compositions.
CN113789316A (en) * 2006-09-21 2021-12-14 巴斯夫酶有限责任公司 Phytases, nucleic acids encoding them and methods of making and using them
EP2097756B1 (en) 2006-12-21 2011-10-19 Novartis AG Antibody quantitation
JP2012197258A (en) 2011-03-23 2012-10-18 Tohoku Univ Method for quantitatively determining absolute mass of marker protein for individualized treatment and diagnosis
MX2013013054A (en) 2011-05-12 2014-02-20 Genentech Inc Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature peptides.
JP6148540B2 (en) * 2013-06-07 2017-06-14 株式会社島津製作所 Method for quantitative analysis of granulin peptide using mass spectrometer and program for analysis
WO2015033479A1 (en) 2013-09-09 2015-03-12 株式会社島津製作所 Method for preparing peptide fragments, kit for preparing peptide fragments to be used therein, and analysis method
US20180052172A1 (en) * 2015-03-10 2018-02-22 Shimadzu Corporation Kit for preparing sample for detecting monoclonal antibody
EP3165922B1 (en) * 2015-11-06 2020-06-17 Promise Proteomics A method for quantifying therapeutic antibodies

Also Published As

Publication number Publication date
JP6428911B2 (en) 2018-11-28
EP3270154B1 (en) 2020-03-04
KR20170121265A (en) 2017-11-01
CN107407666A (en) 2017-11-28
BR112017017854A2 (en) 2018-04-10
EP3270154A1 (en) 2018-01-17
US20180059074A1 (en) 2018-03-01
US10338039B2 (en) 2019-07-02
WO2016143224A1 (en) 2016-09-15
JPWO2016143224A1 (en) 2017-12-28
KR102000862B1 (en) 2019-07-16
EP3270154A4 (en) 2019-01-09

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