EP3262216A4 - Banque de fragments variables monocaténaires présentés sur phage - Google Patents
Banque de fragments variables monocaténaires présentés sur phage Download PDFInfo
- Publication number
- EP3262216A4 EP3262216A4 EP16756185.1A EP16756185A EP3262216A4 EP 3262216 A4 EP3262216 A4 EP 3262216A4 EP 16756185 A EP16756185 A EP 16756185A EP 3262216 A4 EP3262216 A4 EP 3262216A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- phage
- chain variable
- variable fragment
- fragment library
- displayed single
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000012634 fragment Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/245—IL-1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19154062.4A EP3514181A1 (fr) | 2015-02-24 | 2016-02-23 | Banque de fragments variables monocaténaires présentés sur phage et anticorps sélectionnés à partir de celle-ci |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562120352P | 2015-02-24 | 2015-02-24 | |
PCT/US2016/019128 WO2016137992A2 (fr) | 2015-02-24 | 2016-02-23 | Banque de fragments variables monocaténaires présentés sur phage |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19154062.4A Division EP3514181A1 (fr) | 2015-02-24 | 2016-02-23 | Banque de fragments variables monocaténaires présentés sur phage et anticorps sélectionnés à partir de celle-ci |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3262216A2 EP3262216A2 (fr) | 2018-01-03 |
EP3262216A4 true EP3262216A4 (fr) | 2018-12-05 |
Family
ID=56789830
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19154062.4A Withdrawn EP3514181A1 (fr) | 2015-02-24 | 2016-02-23 | Banque de fragments variables monocaténaires présentés sur phage et anticorps sélectionnés à partir de celle-ci |
EP16756185.1A Withdrawn EP3262216A4 (fr) | 2015-02-24 | 2016-02-23 | Banque de fragments variables monocaténaires présentés sur phage |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19154062.4A Withdrawn EP3514181A1 (fr) | 2015-02-24 | 2016-02-23 | Banque de fragments variables monocaténaires présentés sur phage et anticorps sélectionnés à partir de celle-ci |
Country Status (5)
Country | Link |
---|---|
US (1) | US10336816B2 (fr) |
EP (2) | EP3514181A1 (fr) |
CN (1) | CN107614762B (fr) |
TW (1) | TWI636060B (fr) |
WO (1) | WO2016137992A2 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5908466B2 (ja) * | 2010-06-09 | 2016-04-26 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Raf及びmek阻害剤に対する耐性を与えるmek1変異 |
CA3077518C (fr) * | 2016-09-07 | 2021-10-19 | Frederic Fellouse | Anticorps synthetiques contre le vegf et leurs utilisations |
US11434277B2 (en) * | 2017-10-20 | 2022-09-06 | Academia Sinica | Method for high-throughput screening of neutralizing antibodies, neutralizing antibodies produced therefrom, and uses thereof |
CN110079502B (zh) * | 2018-02-07 | 2020-11-06 | 阿思科力(苏州)生物科技有限公司 | Pd-l1 car-nk细胞及其制备和应用 |
CN109929835A (zh) * | 2019-03-27 | 2019-06-25 | 中国人民解放军第四军医大学 | 一种鼠单克隆抗体功能轻链可变区基因的扩增方法 |
US20230168249A1 (en) * | 2020-05-06 | 2023-06-01 | Academia Sinica | Recombinant antibodies, kits comprising the same, and uses thereof |
TW202204379A (zh) * | 2020-06-08 | 2022-02-01 | 中央研究院 | 用以篩選抗體片段的方法、由此製備的重組抗體及其用途 |
WO2022261261A2 (fr) * | 2021-06-08 | 2022-12-15 | Academia Sinica | Banque de fragments variables à chaîne unique présentés sur phage pour la sélection de fragments d'anticorps spécifiques de la mésothéline |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005044853A2 (fr) * | 2003-11-01 | 2005-05-19 | Genentech, Inc. | Anticorps anti-vegf |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2171336C (fr) * | 1993-09-07 | 2011-06-21 | Stephen Dudley Holmes | Anticorps il4 recombinants, utiles pour le traitement des troubles lies a il4 |
US7244826B1 (en) * | 1998-04-24 | 2007-07-17 | The Regents Of The University Of California | Internalizing ERB2 antibodies |
JP2002536968A (ja) * | 1999-01-29 | 2002-11-05 | イムクローン システムズ インコーポレイティド | Kdrに特異的な抗体およびその使用 |
CA2485732A1 (fr) * | 2002-05-20 | 2003-12-04 | Abmaxis, Inc. | Production et selection d'une banque de proteines dans de la silice |
US8148085B2 (en) * | 2006-05-15 | 2012-04-03 | Sea Lane Biotechnologies, Llc | Donor specific antibody libraries |
US20110082052A1 (en) * | 2009-08-11 | 2011-04-07 | Academia Sinica | Phage displaying system expressing single chain antibody |
US9586996B2 (en) * | 2010-04-30 | 2017-03-07 | Esperance Pharmaceuticals, Inc. | Lytic-peptide-Her2/neu (human epidermal growth factor receptor 2) ligand conjugates and methods of use |
EP2699597B1 (fr) * | 2011-04-21 | 2016-06-01 | Garvan Institute of Medical Research | Molécules à domaine variable modifié et procédés de préparation et d'utilisation de celles-ci |
AU2013258844B2 (en) * | 2012-05-10 | 2017-12-21 | Zymeworks Bc Inc. | Single-arm monovalent antibody constructs and uses thereof |
-
2016
- 2016-02-23 CN CN201680009046.7A patent/CN107614762B/zh active Active
- 2016-02-23 EP EP19154062.4A patent/EP3514181A1/fr not_active Withdrawn
- 2016-02-23 EP EP16756185.1A patent/EP3262216A4/fr not_active Withdrawn
- 2016-02-23 US US15/547,523 patent/US10336816B2/en active Active
- 2016-02-23 WO PCT/US2016/019128 patent/WO2016137992A2/fr active Application Filing
- 2016-02-24 TW TW105105362A patent/TWI636060B/zh active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005044853A2 (fr) * | 2003-11-01 | 2005-05-19 | Genentech, Inc. | Anticorps anti-vegf |
Non-Patent Citations (1)
Title |
---|
PANSRI POTJAMAS ET AL: "A compact phage display human scFv library for selection of antibodies to a wide variety of antigens", BMC BIOTECHNOLOGY, BIOMED CENTRAL LTD. LONDON, GB, vol. 9, no. 1, 29 January 2009 (2009-01-29), pages 6, XP021049493, ISSN: 1472-6750, DOI: 10.1186/1472-6750-9-6 * |
Also Published As
Publication number | Publication date |
---|---|
WO2016137992A3 (fr) | 2016-10-27 |
US10336816B2 (en) | 2019-07-02 |
US20180009877A1 (en) | 2018-01-11 |
TWI636060B (zh) | 2018-09-21 |
WO2016137992A2 (fr) | 2016-09-01 |
CN107614762A (zh) | 2018-01-19 |
EP3514181A1 (fr) | 2019-07-24 |
EP3262216A2 (fr) | 2018-01-03 |
CN107614762B (zh) | 2022-08-05 |
TW201632547A (zh) | 2016-09-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20170920 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
DAV | Request for validation of the european patent (deleted) | ||
DAX | Request for extension of the european patent (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C40B 50/06 20060101ALI20180724BHEP Ipc: C12N 15/10 20060101ALI20180724BHEP Ipc: C40B 40/08 20060101AFI20180724BHEP Ipc: C07K 16/22 20060101ALI20180724BHEP Ipc: C07K 16/00 20060101ALI20180724BHEP Ipc: C07K 16/10 20060101ALI20180724BHEP Ipc: C12N 15/73 20060101ALI20180724BHEP |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20181106 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C12N 15/10 20060101ALI20181029BHEP Ipc: C40B 50/06 20060101ALI20181029BHEP Ipc: C07K 16/10 20060101ALI20181029BHEP Ipc: C12N 15/73 20060101ALI20181029BHEP Ipc: C07K 16/00 20060101ALI20181029BHEP Ipc: C40B 40/08 20060101AFI20181029BHEP Ipc: C07K 16/22 20060101ALI20181029BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20190604 |