EP3237034A1 - Appareil pour le traitement de sang - Google Patents

Appareil pour le traitement de sang

Info

Publication number
EP3237034A1
EP3237034A1 EP15841056.3A EP15841056A EP3237034A1 EP 3237034 A1 EP3237034 A1 EP 3237034A1 EP 15841056 A EP15841056 A EP 15841056A EP 3237034 A1 EP3237034 A1 EP 3237034A1
Authority
EP
European Patent Office
Prior art keywords
flow
blood
value
conduit
circuit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15841056.3A
Other languages
German (de)
English (en)
Inventor
Michele Gazzano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Extra Corporeal Solutions Srl
Original Assignee
Extra Corporeal Solutions Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Extra Corporeal Solutions Srl filed Critical Extra Corporeal Solutions Srl
Publication of EP3237034A1 publication Critical patent/EP3237034A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/165—Constructional aspects thereof with a dialyser bypass on the dialysis fluid line
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate

Definitions

  • the present invention relates to an apparatus for blood treatment.
  • the apparatus can be used for the extracorporeal removal of C0 2 . Since several years there are on the market devices to remove the C0 2 from the blood by extracorporeal way, working similarly to the widespread treatments of dialysis, hemofiltration, etc., which remove by an extracorporeal way toxic or harmful waste products of metabolism that normally would be eliminated by the kidneys.
  • a known system for the aforementioned aim dates back more than forty years ago, and is known by the acronym "ECMO" (Extra Corporeal Membrane Oxygenation); it provides an access to larger vessels of the patient performed surgically with large diameter cannulas connected to a pump and to an oxygenator capable of handling high flows (even more than 5 liters per minute).
  • ECMO Extra Corporeal Membrane Oxygenation
  • This system in its numerous variants, is able to completely replace the lung function and, in case, also the heart.
  • the main action of such systems is to remove the excess C0 2 that accumulates in the blood while regarding the oxygenation is the portion of the lung tissue that still works with the aid of normal techniques of Mechanical Ventilation.
  • An object of the present invention is to determine the correct and suitable flow for the treatment, by means of a bifurcation that allows the desired flow to pass in the component with a lower flow and which allows the excess flow to pass freely into a parallel section of conduit.
  • the present invention provides an apparatus for blood treatment, of the type usable to execute a processing of the blood by passing the blood through a circuit comprising a first device suitable to operate at a first flow value and a second device suitable to operate at a second flux value, lower than the first;
  • the apparatus is characterized in that it comprises a bifurcation of said circuit which divides the same circuit in a first conduit, on which is arranged said second device, and a second duct, on which is acting a means for regulating the flow, act to determine a flow value equal to the difference between the value of said first flow and the value of said second flow; said first conduit and said second conduit being gathered between them downstream of said second device and said means for regulating the flow.
  • the said bifurcation may be located downstream or upstream of said first device.
  • the first device can be an oxygenator
  • the second device can be a hemofilter
  • the means for regulating the flow can be a pump or other suitable device to vary the flow such as, for example, a device adapted to vary the section of the duct on which it is agent so as to adjust consequently its flow-through.
  • FIGs 1 , 2 and 3 are diagrams concerning possible examples of embodiment of an apparatus in accordance with the invention, in which the details are presented schematically and not to scale.
  • the apparatus comprises a circuit adapted to the extracorporeal removal of C0 2 by means of a device called oxygenator (3) which takes advantage of the maximum blood flow available and of a hemofilter (6) for CVVH treatments (continuous dialysis) that generally requires (or is planned for) lower flows.
  • oxygenator (3) which takes advantage of the maximum blood flow available and of a hemofilter (6) for CVVH treatments (continuous dialysis) that generally requires (or is planned for) lower flows.
  • CVVH treatments continuous dialysis
  • the blood is drawn through the action of a pump (2) which in this specific but not limitative case generates a flow of 500 ml / min.
  • the aforementioned flow transits entirely within the oxygenator (3) to reach a first bifurcation (4) where it is divided.
  • a second bifurcation (11) brings together the two streams into a single pipe which at the end (12) is connected to the catheter for returning the treated blood to the patient.
  • the pump (9) or the flow regulator device is advantageously positioned between the portions of the tube (8) and (10) so that the excess flow encounters the resistance of the hemofilter (6) in the other branch of the bifurcation and thereby increases the pressure of the blood within the oxygenator (3); this phenomenon limits advantageously the formation of not dissolved oxygen bubbles.
  • Figs. 1 and 2 the means for regulating the flow (9) is schematically represented with a symbol that reproduces a rotors pump.
  • the means for regulating the flow (9) is schematically represented with a symbol that reproduces a rotors pump.
  • different types of pumps of other devices capable of determining the value of the desired flow suitable for the related device that is crossed.
  • it may be employed a device that allows to reduce the internal section of the tube in order to adjust the relative How.
  • the pump (or the flow restrictor device) (9) can advantageously be positioned also in correspondence of the branch (5) or in the branch (7) of the circuit, as shown schematically in Fig.3.
  • Fig. 3 are represented three of the possible different positions that can assume the device (9).
  • the portion of the circuit with the subdivision in the two branches (5, 7) and (8, 10) is positioned downstream of the component having a greater flow, which can be an oxygenator (3); the portion with the subdivision can also be placed upstream of this device (3), as shown in the example of Fig.2.
  • circuits of the drawings the possible components not directly affected by the invention are not represented; in fact, a circuit of the type described may comprise, for example, means for collecting the ultrafiltrate, means for infusing substances in the blood, means for controlling the presence of bubbles, means for adjusting the temperature, connections to sources or oxygen tanks, etc. ..
  • the blood which is drawn from the patient through a catheter in correspondence of the end (1) of the circuit, is pushed downstream by the first pump (2) to the oxygenator (3), which is traversed by a flow which is suitable to its optimal operation because the pump (2) determines a flow equal to the optimum value expected for the oxygenator (3).
  • the bifurcation (4) which divides the circuit into two branches.
  • the value of the blood flow passing through is regulated by the pump (9) and, therefore, in the other branch (5, 7) the value of the blood flow is equal to the difference between the upstream flow, the one passing through the oxygenator (3), and the flow of the right branch, so as to also the second device (6) operates at the optimum flow, even when this is different from the flow of the first device (3 ).
  • the first pump (2) imparts to the blood a flow of this value so as to optimize the operation of the oxygenator (3).
  • the action of the second pump (9) which determines a flow of 300ml / min into the right branch lowers the value of the flow in the left branch (5, 7 ) up to the optimal value for the hemofilter (6), in this case 200ml / min.
  • the circuit Downstream from the branch, after the point (1 1), the circuit is joined and the blood returns to the patient through the end (12) at the same flow that it had initially.
  • the regulation of the flow for the second device (6) takes place upstream of the first device (3).
  • the values of the flows of the blood in the part of the circuit with the branch are the same as the previous example, and the flow of blood downstream is received by the first device (3) with a flow equal to the output from the first pump (2) arranged upstream.
  • the present invention relates to an apparatus for the treatment of the blood of the type usable to execute a processing of the blood by passing the blood through a circuit comprising a first device (3) capable of working a first flow value, a first flow-adjusting means (2) adapted to determine a blood flow having said first value, and a second device (6) suitable to operate at a second flow value, lower than the first.
  • the apparatus comprises a bifurcation (4) of the circuit which divides the same circuit in a first conduit (5, 7), which comprises said second device (6), and a second conduit (8, 10), on which is acting a second flow regulator means (9), adapted to determine a flow value equal to the difference between the value of said first flow and the value of said second flow; said first conduit (5, 7) and said second conduit (8, 10) being joined between them downstream of said second device (6) and of said flow regulator means (9).
  • the first means for regulating the flow (2), as well as the second means for regulating the flow (9) may be pumps.
  • conduits therefore circulates the blood, and the bifurcation divides the circuit into two ducts in which blood circulates.
  • oxygenator (3) and hemofilter (6) are components of the apparatus and not machines linked together. These devices are, in practice, individual components that are part of a circuit preassembled to work aboard of a machine specifically intended.
  • the invention also describes a process for the treatment of the blood.
  • a process in accordance with the invention involves the following operative steps:
  • the first device (3) being an oxygenator and the second device (6) being a hemofilter.
  • the process comprises the use of an apparatus made as described above.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention concerne un appareil pour le traitement de sang, du type utilisable pour réaliser un traitement du sang par passage du sang à travers un circuit comprenant un premier dispositif (3) approprié pour fonctionner à une première valeur d'écoulement et un second dispositif (6) approprié pour fonctionner à une seconde valeur d'écoulement, inférieure à la première ; l'appareil est caractérisé par le fait qu'il comprend une bifurcation (4) dudit circuit qui divise le même circuit en un premier conduit (5, 7), sur lequel se trouve ledit second dispositif (6), et un second conduit (8, 10), sur lequel agit un moyen pour réguler l'écoulement (9), conçue pour déterminer une valeur d'écoulement égale à la différence entre la valeur dudit premier écoulement et la valeur dudit second écoulement ; ledit premier conduit (5, 7) et ledit second conduit (8, 10) étant reliés ensemble en aval dudit second dispositif (6) et dudit moyen pour réguler l'écoulement (9).
EP15841056.3A 2014-12-22 2015-12-21 Appareil pour le traitement de sang Withdrawn EP3237034A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITFI20140303 2014-12-22
PCT/IT2015/000316 WO2016103290A1 (fr) 2014-12-22 2015-12-21 Appareil pour le traitement de sang

Publications (1)

Publication Number Publication Date
EP3237034A1 true EP3237034A1 (fr) 2017-11-01

Family

ID=52574253

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15841056.3A Withdrawn EP3237034A1 (fr) 2014-12-22 2015-12-21 Appareil pour le traitement de sang

Country Status (2)

Country Link
EP (1) EP3237034A1 (fr)
WO (1) WO2016103290A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITUB20159161A1 (it) * 2015-12-18 2017-06-18 Eurosets Srl Apparecchiatura per la decapneizzazione del sangue
DE102017210134A1 (de) 2016-12-15 2018-06-21 Fresenius Medical Care Deutschland Gmbh System zur extrakorporalen Blutbehandlung, Behandlungsvorrichtung, Kit und Verfahren zum Betreiben eines Systems zur extrakorporalen Blutbehandlung
WO2018145035A1 (fr) 2017-02-03 2018-08-09 Nxstage Medical, Inc. Dispositifs, méthodes et systèmes de traitement multimode

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769163A (en) * 1971-11-08 1973-10-30 R Brumfield Blood oxygenator flow guide
EP1888211B1 (fr) * 2005-04-21 2014-01-08 University of Pittsburgh of the Commonwealth System of Higher Education Poumon-para-corporel d'assistance respiratoire
US8372025B2 (en) * 2005-09-22 2013-02-12 Baxter International Inc. Automation and optimization of CRRT treatment using regional citrate anticoagulation
EP2238995A1 (fr) * 2009-04-09 2010-10-13 Gazzano, Michele Système pour le traitement sanguin
US8080161B2 (en) * 2009-06-11 2011-12-20 Baxter International Inc. Dialysis treatment devices for removing urea
US9034191B2 (en) * 2010-02-24 2015-05-19 The Regents Of The University Of Michigan Vibration-assisted dialysis method
CN202270211U (zh) * 2011-09-28 2012-06-13 虞文魁 一种体外膜氧合氧合器与血液滤过机一体化装置

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
None *
See also references of WO2016103290A1 *

Also Published As

Publication number Publication date
WO2016103290A1 (fr) 2016-06-30

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