EP3216010A1 - Imagerie en trois dimensions du mouvement des dents et des mâchoires - Google Patents

Imagerie en trois dimensions du mouvement des dents et des mâchoires

Info

Publication number
EP3216010A1
EP3216010A1 EP15858010.0A EP15858010A EP3216010A1 EP 3216010 A1 EP3216010 A1 EP 3216010A1 EP 15858010 A EP15858010 A EP 15858010A EP 3216010 A1 EP3216010 A1 EP 3216010A1
Authority
EP
European Patent Office
Prior art keywords
teeth
jaw
data
treatment
jaws
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15858010.0A
Other languages
German (de)
English (en)
Other versions
EP3216010A4 (fr
Inventor
Shane MATT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US2015/059340 external-priority patent/WO2016073792A1/fr
Publication of EP3216010A1 publication Critical patent/EP3216010A1/fr
Publication of EP3216010A4 publication Critical patent/EP3216010A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/45For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4538Evaluating a particular part of the muscoloskeletal system or a particular medical condition
    • A61B5/4542Evaluating the mouth, e.g. the jaw
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/0035Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/0036Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room including treatment, e.g., using an implantable medical device, ablating, ventilating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/06Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
    • A61B5/061Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
    • A61B5/062Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body using magnetic field
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/103Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/11Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
    • A61B5/1126Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb using a particular sensing technique
    • A61B5/1127Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb using a particular sensing technique using markers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/45For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4538Evaluating a particular part of the muscoloskeletal system or a particular medical condition
    • A61B5/4542Evaluating the mouth, e.g. the jaw
    • A61B5/4557Evaluating bruxism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00Dental auxiliary appliances
    • A61C19/04Measuring instruments specially adapted for dentistry
    • A61C19/045Measuring instruments specially adapted for dentistry for recording mandibular movement, e.g. face bows
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C7/00Orthodontics, i.e. obtaining or maintaining the desired position of teeth, e.g. by straightening, evening, regulating, separating, or by correcting malocclusions
    • A61C7/002Orthodontic computer assisted systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02Operational features
    • A61B2560/0223Operational features of calibration, e.g. protocols for calibrating sensors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0219Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0223Magnetic field sensors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0073Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4836Diagnosis combined with treatment in closed-loop systems or methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/51Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for dentistry
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A61B8/0875Detecting organic movements or changes, e.g. tumours, cysts, swellings for diagnosis of bone

Definitions

  • the claimed subject matter relates generally to the generation of three dimensional (3D) imaging of the teeth and jaws and., more specifically, with the capture of 3D images and various techniques that utilize the 3D imaging.
  • TMD Temporomandibular Joint Dysfunction
  • TM1 it is not only the TM1 that is of concern. More comprehensively known as eraniomandibiilar dysfunction, other signs and. symptoms include head and neck pain, dental pain, worn, broken or mal-a!igned. teeth, broxism (grinding teeth) among many others. Even sleep apnea is associated jaw issues. A patent airway is the most critical issue for survival. Chronic partial obstruction from sleep apnea can lead to numerous systemic health problems most adversely being with the heart. There is not currently an affordable comprehensive system that displays the relationship between these health problems and successful treatment.
  • Radiography Another commonly prescribed imaging option is radiography. Corrected tomography is significantly less expensive than MRI/CT, but the quality is substandard. Like CTs there is no visualization of (he soft tissue. One may see the position of the jaw in the joint, but can only mentally visualize the status of the soft tissues. Advantages of tomography are that it is an affordable office option, and can be useful in analyzing arthritic change of the bone.
  • Devices include video tracking, ultrasound and more commonly, various magnetic systems.
  • One such magnetic system is achieved with a sensory array that tracks a magnet- attached to the lower front teeth. The magnet movement is graphically depicted on-screen in real-time, and dysfunction in the joints can be deduced by analyzing the tracing.
  • J 008J For example, an. internal derangement in the right joint will result in a deviation to the right until the joint disc is recaptured, and the jaw moves back toward the midline. If the derangement is in both joints and the joint disc cannot be recaptured there will be limited opening.
  • the integrity of the soft tissue in function remains a mystery, although audio joint sonography gives some insight.
  • a spectral analysis of the irequencies emitted during joint function reveals whether there is soft tissue damage or if there is bone on bone contact.
  • Pre-calibrated position sensors, and a computer or cloud based service are used to show motion in real time of the teeth and jaws depicting six degrees of freedom.
  • the computer receives anatomically correct 3D images of any portion of the craniomandibular system with a position sensor(s) attached.
  • the position sensor data is then transferred with wireless attachments to the patient to generate true to life motion of the digital 3D models of the teeth and jaws.
  • a computer or cloud based service is used to correlate 3D real motion visualizations to physiologic measurements.
  • True to life motion of anatomically correct 3D digital models allows one to see individualized function of the jaws and teeth.
  • the addition of measurable physiologic variables will give a comprehensive understanding of craniomandibular system health and improve treatment, fOOM j
  • the purpose of this disclosure is to describe an affordable, easy to use and highly accurate system to animate actual images of an individual's teeth in function.
  • These 3D visualizations may be referenced by imaging a wireless position sensor system bonded directly to the teeth or anchored in the jaw. The data may be correlated to MR!
  • CMD craniomandibular disorders
  • Magnetic resonance imaging (MRl); computed tomography (CT); radiographs; sonography; jaw tracking; eiectromyogram (EMG); digital photography; and exact replica, mounted models of the teeth are the most common diagnostic tools of CMD. This information, usually gathered at different times and locations, is used to formulate a diagnosis and treatment, often resulting in a slow, difficult and. expensive process.
  • Jaw tracking is achieved with a sensory array that tracks a magnet attached to the lower front teeth.
  • the magnet movement is graphically depicted on-screen in realtime, and dysfunction in the joints can be deduced by analyzing the tracing.
  • the previously known techniques only give physicians a three-dimensional graphic of a single point tracing, a limitation that makes it difficult to fully evaluate and understand the technical problems to be addressed, especially given the jaw's six-dimensional pitch, roll and yaw.
  • EMG is also an important component to analyzing jaw function.
  • a dysfunctional jaw position wil l result in an adaptive posture of the jaw muscles through the neuromuscular system.
  • the adaptive posture is pathologic causing excessive tension in the musculature. This can result in headaches, TMJ problems, facial, pain and. even ear problems, in the body's attempt to maintain homeostasis, an individual may also begin to grind the teeth to eliminate the interferences that prohibit the muscles from functioning with equal tension.
  • EMG can be correlated to jaw position for increased diagnosis and treatment ability.
  • Three-dimensional jaw tracking graphics combined with EMG is vita! to providing objective data for diagnosis and treatment, images of the TMJs are again necessary, of the exact evaluation position, to help assemble a mental six dimensional picture of the jaw and both TMJs function,
  • 3-D graphic depictions e.g., Cerec, iTero, Lava, True Definition
  • an treatment derived from these systems is based on a habitual, even pathologic bite with little or no consideration of associated physiologic parameters.
  • polysomnography includes EKG, EEC, blood oxygen, respiratory rate, blood pressure, body position, limb movement, and REM.
  • U.S. Patent application 20120015316 by Saehdeva, et at. describes the use of jaw tracking with every visualization method known to man. to acquire 3D models. Jaw tracking methods available at the time of the aforementioned application have been in use for decades. There is no reference to correlating physiologic parameters including EMG, joint sonography (recording and analyzing joint sounds), B G, pulse oximetry, blood pressure; heart rate, pharyngometry or rhinonietry. There is a vague reference to telemetric jaw tracking, but there is no description of how such device works.
  • U.S. Patent 5,826.579 to Remmers, et al. is Somnorned's positioner, MATRx. It moves the jaw anterior and posterior, with the teeth locked in trays. It gives data relating the jaws A/P position to physiologic measurements, but it is a manipulated position, it cannot give functional data without a large controller in the mouth. Furthermore, there is no way to relate the physiologic data to 3D anatomic models in the natural functioning jaw positions of a patient,
  • U.S. patent 8,667,972 to Makkar et al discloses the fabrication of a mouthpiece from a. bite registratio acquired using jaw tracking and EMG analysis
  • Makkar, et al. discuss the use of impressions and molds of the teeth and does not describe the correlation to digital data or a functional analysis.
  • Makkar does not reference iVfyo- Tronics
  • Adib's disclosure regarding jaw tracking is a sensory array Velcro strapped to the head that tracks a magnet placed on the lower teeth with stick wax.
  • U.S. patents 8,226,407 and 8,550,816 to Hanewinkei, et al discuss the association of pharyngomeier results with a manual or robotic device that protrudes outside of the mouth for the manipulation of the jaw and recording the bite position with registration material it is not a system that can gather data on position in everyday function, nor does it give data that can demonstrate normal functional movements and is useless during polysomnography
  • U.S. patent 8,620,04 5 to Adams is a video camera based tracking system with fiduciary makers. It is not a wireless positioning sensor system as RFID, biuetooth or data storage are not referenced, Adams mentions measuring muscle function, but makes no reference t the method of acquiring such data.
  • U.S. patent 5,989.023 to Summer, et al. is a wireless motion system that records the projection of light from a source mounted adjacent to a dental arch. It too is a novel system but like the above listed disclosures, none define relating jaw position to a panel of physiologic measurements, in particular EMG, EKG, BEG, pulse oximetry, blood pressure, heart rate, respiratory rate, tooth contact sensors, phaiyngotnetry or rhmometry.
  • a computer or cloud based service is used to correlate 3D real motion visualizations to physiologic measurements.
  • True to life motion of anatomically correct models allows one to see individualized function of the jaws and teeth.
  • CAD/CAM Software is used to design one or more appliances to move the teeth to a new bite position. Appliances are milled, or 3D printed to physiologic measurements such as electromyography, pulse oximetry, blood pressure, heart rate, respiratory rate, pharyn gome try, rhinometry, tooth contact sensors, cervical and vertebral posture, among others.
  • digital anatomical models are used to design appliances whether for palliative orthopedic repositioning, dental reconstruction, orthodontic aligners, space maintainers or sleep apnea appliances that could be printed, milled or sent to a lab for fabrication.
  • This disclosure integrates anatomical models and physiologic measurements of a given individual to produce a treatment result that includes specific inter-occlusal dimensional changes.
  • Current methods of treating malocclusions with orthodontic aligners, steep apnea with mandibular advancement appliances, and hraxism or ⁇ dysfunction with removable appliances use either manual polyvinyl impressions and stone models, or 3D imaging and printing of models.
  • Each of the aforementioned health problems are related in that they are all craniomandibular disorders. (CMD)
  • Invisalign is a system to straighten teeth with clear aligners; however, there are no associations to physiologic data. This is imperative knowledge considering the affiliations to systemic conditions that malocclusions are related to.
  • Jaw tracking is achieved with a sensory array that tracks a magnet attached to the lower front teeth.
  • the magnet movement is graphically depicted on-screen in realtime, and dysfunction, in the joints can be deduced by analyzing the tracing.
  • the previously known techniques only give physicians a three-dimensional, graphic of a single point tracing, a limitation that makes it difficult to fully evaluate and understand the technical problems to be addressed, especially given the jaw's six-dimensional pitch, roil and yaw.
  • E G is also an important component to analyzing jaw function
  • a dysfunctional jaw position will result in an adaptive posture of the jaw muscles through the neuromuscular system.
  • the adaptive posture is pathologic causing excessive tension in the musculatiire. This can resuli in headaches, TMJ problems, fecial pain and even ear problems.
  • an individual may also begin to grind the teeth to eliminate the interferences that prohibit the muscles from functioning with equal tension.
  • EMG can be correlated to jaw position for increased diagnosis and treatment ability.
  • Three-dimensional jaw tracking graphics combined with EMG is vital to providing objective data for diagnosis and treatment. Images of the TMJs are again, necessary, of the exact evaluation position, to help assemble a menial six dimensional picture of the jaw and both TM Js function.
  • FIGURE 1 is an illustration of jaws and teeth with sensors attached in accordance with the claimed subject matter.
  • FIGURE 2 is an i I lustration of the teeth and jaws of FIG. 1 showing dimensional relationships as measured between the upper and lower teeth/jaws in a clench to compare to treatment positions,
  • FIGURE 3 illustrates a functional analysis of the teeth/jaw system of FIGS. 1 and 2.
  • FIUGRE 4 is an illustration of a layout one embodiment of a sensor in accordance with the claimed subject matter.
  • FIGURE 5 is an illustration of a patient undergoing a simultaneous bilateral ultrasound.
  • FIGURE is an illustration of a 3 -dimension (3D) computerized axial tomography (CT) scan.
  • FIGURE 7 illustrates two (2) of a temporomandibular joint (T ' MJ), including a Sagittal CT view and a view of a Coronal ultrasound section.
  • FIGURE 8 is a block diagram of a computing architecture in which the disclosed technology may be implemented
  • FIGURE 9 is a flowchart of a "Plan Treatment" process thai may implement aspects of the claimed subject matter.
  • FIGURE 1 is a flowchart of an "Implement Treatment” process that may incorporate aspects of the claimed subject matter. DETAILED DESCRIPTION OF THE FIGURES
  • a ''memory" or “recording medium” can be any means that contains, stores, communicates, propagates, or transports the program and/or data for use by or in conjunction with an instruction execution system, apparatus or device.
  • Memory and recording medium can be, but are not limited to, an electronic, magnetic, optical, electromagnetic or semiconductor system, apparatus or device.
  • Memory and recording medium also includes, but is not limited to, for example the following: a portable computer diskette, a random, access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (BPEOM or flash memory), and a portable compact disk read-only memory or another suitable medium upon, which, a program and/or data may be stored.
  • a plurality of radio transceiver micro controllers with magnetometers are placed on one arch and a .magnet(s) on the opposing arch, which ma also be used with aceelerorneters and/or gyroraeters.
  • a 3D scanner, 3D CBCT or other system capable of generating 3D files will, be used to create 3 pairs of files (with and without sensors) of the teeth and jaws.
  • the three pairs are the upper teeth., the lower teeth and of the teeth together at the habitual bite in a clench.
  • the pairs are correlated to displa with and without tracking sensors attached to the teeth.
  • the teeth together in habitual bite are the zero point.
  • Tracking sensor dat may also be applied to the 3D images without images of the sensors in place. Synchronization via time stamping allows for correlation of tracking data to other physiologic data inputs after downloading whe wireless connectivity cannot be established.
  • the position for the digital 3D models begins with setting the HIP plane of the maxilla level to the horizon.
  • the right and left llatnuiar notches and incisive canal are selected o the digital models, whether on photograph, video, radiography (CT).
  • CT radiography
  • the horizontal plane of these three points can be compared to a photograph of the patient standing upright to determine the correct plane and smile line in relation to the H IP selection.
  • the motion capture dat is then applied to the 3D models to show function and range of motion of the jaw.
  • multiple freeze frame positions of the spatial relationship between the upper and the lower jaw can be saved. Measurement tools precisely determine the spatial dimensions at freeze frame positions between pairs of upper and lower teeth to determine pitch, roll, yaw, lateral shift of the jaw.
  • J 060J In some treatment methods, as with Transcutaneous Electric Neural Stimulation, there is a significant change in the mandibular posture in relation to the cranium and upper teeth.
  • This disclosure includes calculating the exact square area and dimensions of the teeth to gain full contact of the teeth based on a treatment trajectory. A treatment choice may be determined to either reshape the teeth mechanically, or move the teeth to a new bite position. Correct determination is critical as excessive removal of tooth structure can be destructive and orthodontics could be unnecessary to correct a bite.
  • Transcutaneous Electric Neural Stimulation, anterior deprogramming and centric relation are among the many methods used to treat TMJ issues, malocclusion, sleep apnea and a myriad of functional dental problems. Each one is capable of changing the bite.
  • This disclosure provides a method to measure the difference between habitual bite and a new treatment position.
  • Adjustment coping trays may also be created by milling or 3D printing so that only the exposed areas of the tray are open to indicate areas to be adjusted. If equilibration is not indicated, then an appropriate physiologic bite position can be chosen. In this scenario, the teeth may be completely apart, or at the first contact of a single pair of upper and lower teeth where the remaining teeth are apart.
  • a user may add other data sources such as simultaneous ultrasound imaging of the jaw joints as correlated to radiographs, CT or MM to give positional data with six degrees of freedom.
  • Matching reference points are selected between the ultrasound images and CT/'MRI images to be synchronized so that a fully functional digital model may be displayed, if only unilateral ultrasound images are available, then the positional sensors described above in the primary embodiment can be utilized upon 3D visualization to display a dynamic functional model, in either scenario, the measurements described in the primary embodiment are applicable,
  • a dual ultrasound probe correlated with 3D CT also works as a standalone solution or with wireless position sensors to animate mandibular motion, The use of both would allow for duplicity and verification of accuracy between the animated motion solutions.
  • the system contemplated herein comprises one or more wireless sensory devices used to capture motion data.
  • This data correlated with digital 3D models provides valuable information reaardine jaw function and motion to dentists, orthodontists, and oral surgeons.
  • the functional digital models have the ability to combine with other imaging systems to present the user with a complete graphic analysis of what is occurring in the jaw joints and the relationship between the upper and lower teeth.
  • the correlated data points are used to create an accurate functional anatomic graphic of the craniomandibular complex in real time or via iimestamp.
  • the sensor data and visualization can be combined with three-dimensional CT s, MRJs and ultrasound, which will allow mandibular tracking, animate fusion of anatomic models, three-dimensional imagery, and a meaningful correlation of joint sounds within the digital model, law position sensor data is also correlated with Pulse Oximetry, heart rate, ECG of the heart, brain EEG, REM, Blood pressure, and skeletal muscle EMG in .real time, either simultaneously or with time stamping, EMG activit of the jaw muscles, including wireless EMG data that can be customized to a graphical display and show tissue simulation of function for the muscle groups of the jaw, whereby the muscles change color for various EMG levels between rest and extreme hyperactivity. Muscle tissue may also be visualized with ultrasound and depict pathology such a taut bands of muscle fibers on the comprehensive display, such that all the eraniomandibuSar muscles may be displayed on the anatomic model.
  • the craiiomandibular position sensor data is aiso be compatible with a .manual or electronic jaw positioner.
  • Electronic jaw positioners are currently used during sleep studies to adjust anterior and posterior movements. This data could then be transferred to the digital 3D models to display the exact position of the craniomandi.bul.ar complex.
  • Cervical and other postural vertebral data is another important correlate.
  • the center of rotation, for the mandible is between C1 -C2.
  • Real-time analysis showing the relationship between cramomandibular and vertebral posture is therefore integral to connecting supportive healthcare providers such as chiropractors, physical therapists and medical doctors.
  • Position sensor data as related to 3D imaging shows the contact position of the teeth as the beginning point of motion. Those contacts are confirmed by correlation with tooth contact sensor data. Foil thin bite wafers are placed betwee the teeth, that display the amount of pressure on any given tooth contact. Correlation of these two data sources serves as verification and. increased accuracy of the dynamic 3D models,
  • one or more wireless sensors using aceelerorneters, magnetometers and gyroscopes are bonded to the teeth or affixed to the jaw.
  • Image capture with any 3D visualization (video, Mill, CT, radiographs, ultrasound) system to create 3D graphical models is then put into motion based on the data from the tracking sensors.
  • the sensor data may be transmitted, via Bluetooth, radio frequency or any wireless transmission method.
  • the 3D visualizations will show jaw position in relation to heart activity (EKG), pulse oximetry, EMG of jaw muscles as well as correlation to cervical spine and other postural measurements that will affect jaw positioning.
  • the device utilizes high frequency ultrasound probes (e.g., 32 - 15MHz) to see a maximum visible depth of 10-15 millimeters and allow detailed measurements of the joint and disc location.
  • high frequency ultrasound probes e.g., 32 - 15MHz
  • the area to be visualized is approximately 15 millimeters by 40 millimeters.
  • An adjustable mounting system places the probes in an appropriate position for scans, in an alternative embodiment, the hardware i a stand-alone system, outfitted such that it can move freely from patient to patient as necessary. In another embodiment, the hardware is securely attached to a denial chair or other area used for stationary diagnostics.
  • the software has the capacity to custom design inter- occlusai appliances or orthodontic aligners that may be produced with a 3D printer, milled, or fabricated in a lab.
  • Orthotics, orthopedic repositioning appliances, night guards and protective or performance appliances may be produced in various ergononiie arrangements, in a preferred embodiment, a bite position is chosen to treat in and an appliance design is chosen from, a library.
  • the appliance detail is formed on the shape of an individual's teeth and customized based on motion analysis and an optimal treatment position according to physiologic measurements. Treatment of dysfunctions are readily achieved with a series of three-dimensionally printed orthodontic, orthopedic repositioning appliances and/or jaw aligners designed in correlation with one or more physiologic measurements such as Pulse Oximetry, heart activity, respiratory rate, EMG, REG, EKG, joint sonography, jaw tracking- magnetic, video, ultrasound, radio transmitter and any other as yet undeveloped but compatible systems.
  • physiologic measurements such as Pulse Oximetry, heart activity, respiratory rate, EMG, REG, EKG, joint sonography, jaw tracking- magnetic, video, ultrasound, radio transmitter and any other as yet undeveloped but compatible systems.
  • appliances milled, printed or otherwise produced in accord with physiologic measurements comprise sleep apnea appliances.
  • Digital 3D models of the teeth are acquired and a treatment position is chosen within the parameters and correlation of physiologic measurements with or without motion analysis.
  • a particular appliance design is selected from a library of sleep apnea appliance designs and applied to the physiologic inter-ocefusal mode! space.
  • Customization tools in the software allow the technician to create an individualized appliance in accordance with objective physiologic data measurements, A doctor may utilize 3D printing or milling to deliver these appliances in a much more efficient manner than is currently available.
  • aligners may comprise incremental steps in changing the positioning of the teeth in accord to a predefined, specific inter-oce!usal spatial dimension.
  • aligners such as Jnvtsalign, Clear Correct, etc.
  • aligners cannot correct vertical, pitch, roll or yaw changes to the bite and are not correlated to other associated physiologic data as mentioned above.
  • the system may employ brackets, rubber bands, and/or buttons and wells on aligners to achieve a desired eruption position for the teeth.
  • This disclosure is a visualization system that, correlates motion and functional analysis with physiologic data will give dentists the ability to easily analyze these conditions.
  • images may be acquired with video from a system such as CEREC, hero or 3M * s True Definition Scanner. These images are currently converted to static 3-D models.
  • the software described herein combines the static 3-D models with data acquired from EMG, Jaw Tracking, Joint Vibration / Sonography or any of the other above mentioned medical imaging applications to render a true physiologic anatomic model of the human cran.iomandlbular complex. Once a new treatment position is determined an appliance or dental prosthesis is designed and printed, milled or sent to a lab for fabrication to begin treatment.
  • treatment is centered on physiologic data.
  • Golden proportions a ratio of 1.618:1, ideal curvatures ⁇ Spec & Wilson) in the sphere of occlusion, horizontal smile line and other components of posture are capable of optimization within the scope of this disclosure.
  • the treatment scenarios and aforementioned embodiments may also be correlated to sonography (joint sounds or vibration), or ultrasound imaging in a comprehensive evaluation system. They may also correiaie to physiologic data from (but are not limited to) pharyngometer, rhinometer and any other appropriate airway measurement.
  • FIGURE 1 is an illustration of jaws and teeth, or teeth/jaw system 1.00, with sensors attached in accordance with the claimed subject matter.
  • An upper jaw .102 includes teeth 104 and a lower jaw 106 includes teeth 108.
  • An A sensor 11.2 is attached to the middle teeth of teeth 1.04 and a B sensor 116 is attached to the middle teeth of teeth 1 8
  • teeth 104 and 108 are prepared for bonding.
  • a delivery jig (not shown), affixed to both sensors 1 2 and 1.16 of the sensor pair (A & B) ensure that the pair 112aod 116 are in a calibrated position.
  • the sensor pair 112 and 1.16 are calibrated after installation on teeth 104 and 108.
  • the sensor pair 112 and 116 is positioned and bonded with teeth 104 and 108 closed together such that an upper tooth and lower tooth have a bonded component, then the delivery jig is remo ved with the pair of sensors 112 and 11.6 are in calibration and normal function can be measured.
  • sensor pairs 11.2and 116 are removed and the residue of the bonding material, is removed from teeth 104 and 108.
  • sensor pair 112 and 116 are positioned o opposing teeth 104 and 108. respecti vely, at the back of the jaws 102 and 106, respectively, to nii.nim.tze the potential distance between sensors 112 and 1.16 when teeth 104 and 108 are apart.
  • Multiple sensor pairs may also be employed.
  • FIGU RE 2 is an illustration of teeth/jaw system 100, including upper and lower jaws 102 and 106 and teeth 104 and 108 of FIG. 1 , showing dimensional relationships as measured between upper and Iowerjaws 102 and 106 and teeth 104 and 108 in a clench to compare to treatment positions,
  • Lower jaw 108 moves with six (6) degrees of freedom. The following measurements may be taken to accurately define the spatial relationship of lower teeth 108 to upper teeth 104.
  • Inter-oeclusal space 124 is the difference between a & b above, when compared to various positions.
  • the spatial relationships a-f can be compared to show changes in the x, y, z axes with respect to pitch, roll and yaw.
  • FIGURE 3 illustrates a functional analysis of " teeth/jaw system 100, including upper and iower jaws 102 and 106 and teeth 104 and .108, introduced above in conjunction with FIGs. land 2.
  • This graphic representation demonstrates damage to the teeth caused by vector forces 142 measured with sensor tracking in accordance with the claimed subject matter. Wear patterns on the teeth, recession and ahimctio of the gum/root area of the teeth are indicated in an area 144.
  • tooth structure 146 that may be necessary to be removed in accordance with the claimed subject matter to idealize how the teeth come together is displayed. Radiographs and 3D video/photo images are used to calculate the surface area of the tooth that a patient has worn away by grinding the teeth together to determine how much wear has already occurred.
  • FIGU E 4 illustrates a layout of a sensor I SO that may implement the claimed subject matter, in one embodiment, a pair of sensors (see 112, 116, FIG, 1 ) with a microprocessor, data storage, time clock, battery 154 and magnetometer 156 are placed on lower jaw 1 6, while a pair of magnets 158 are placed on the opposing jaw 102. Additional embodiments, may include an accelerometer, gyroscope, compass, bluetooth and RF transceiver in sensor 156. in the alternative, only one sensor and one magnet may be used. It should be noted, that, if place at the rear of jaw, the potential distance between the sensor and the magnet is minimized for potentially more accurate measurements. It should be noted that FIG, 4 illustrates only one potential sensor configuration. The placement of magnets, accelerometers and so on may be on one or bot of a pair in different numbers.
  • FIGURE 5 is an illustration 200 of a patient 202 undergoing a simultaneous bilateral, ultrasound.
  • Such ultrasound Imaging of right and left TMJ's gives positional information regarding the joint disc and motion tracking by tracking marked data points and correlating to position sensor motion tracking.
  • Included are a pair of ultrasound transmitter/receivers 204 and arms 206 to hold the patient's head in position during measurements.
  • FIGURE 6 is an illustration of a 3 -dimension (3D) computerized axial tomography (CT) scan 250.
  • Scan 250 represents acquisition of bony anatomy for 3D volume to be correlated with other data, as explained in more detail below in conjunction with FIGs. 7-10.
  • FIGURE 7 illustrates two (2) of a temporomandibular joint (TMJ). including a Sagittal CT vie w 302 and a view of a Coronal, ultrasound section 304, Numbered elements and data points in views 302 and 304 correlate with each other.
  • Elements shown in each view 302 and 304 include a mandibular condyle 311, a temporal bone 312, an articular disk 313 and a joint capsule 314.
  • Correlated data points which include data points 315, 316 and 3.17, provide, positioning information so thai a space 318 in 3D CT 302 ma be fused with ultrasound data 304, positioning sensor 156 (FIG. 4) and other accessory data.
  • a plurality of data points are selected to correlate between the 3D CT and ultrasound so that soft tissue data in the ultrasound ⁇ see FIG, 5 ⁇ is fused wit the 3D CT (see FIG. 6).
  • Motion, of the fused system based on ultrasound is correlated with position sensor motion tracking for rendundacy checks.
  • Data points include mandibular condyle 31.1, temporal bone 31.2. articular disc 313 and joint capsule 314. Points that may be correlated between the 3D CT scan and the ultrasound include points 315, 316 and 317, n addition, soft tissues joint space 108 may e visualized in an ultrasound.
  • FIGURE 8 is a block diagram of a computing and device generation architecture 350 in which the disclosed technology may be implemented.
  • a computing system 352 includes a central processing unit (CPU) 354, coupled to a monitor 356, a keyboard 358 and a pointing device, or "mouse,” 360, which together facilitate human interaction with computing system 350 and computing system 352,
  • CPU central processing unit
  • a keyboard 358 and a pointing device, or "mouse,” 360 which together facilitate human interaction with computing system 350 and computing system 352
  • CRSM computer-readable storage medium
  • CRSM 362 is illustrated storing an operating system (OS) 364 and an example of computing code, or device generation system (DOS), 366 that, in the following examples implements aspects the claimed subject matter.
  • OS operating system
  • DOS device generation system
  • Computing system 352 and CPU 354 are connected to a network 370, which is also connected to a data collection module 372, which represents the many different sources of information for the disclosed technology (see 461-470, 472 and 473, FIG, 1.0). Also coupled to network 370 are a 3D printer 374, milling tools 376 and 3D glasses 378. Although in this example, computing system 252 and data collection 372, 3 D printer 374, milling tools 376 and eyeglasses 378 are communicatively coupled via network 370, they could also be coupled through any number of communication mediums such as ? but not limited to, hard wires and the Internet (not shown). Further, it should be noted there are many possible computing system configurations, of which computing architecture 106 is only one simple example.
  • FIGURE 9 is a flowchart of a "Develop Plan" process 400 that may implement aspects of the claimed subject matter, i this example, aspects of process 400 are associated with logic stored on CRSM 362 (FIG. 8) in conjimciion with DGS 366 (FIG. 8) and executed on one of more processors (not shown) of CPU 354 (FIG. 8) of computing system. 352 (FIG. 8).
  • [00101 j Processing starts in a "Begin Plan Treatment” block 462 and proceeds immediately to a "Take 3D Image” block 304.
  • a 3D image of teeth jaws 160 (FIG. 1-3) is taken.
  • sensors (see 112, 11 , FIG. I and 150, FIG. 4) are attached to jaw/teeth 100 (FIGs. 1-3).
  • 3D images of teeth/jaws .100 are acquired the sensors in place. In single sensor arrangement, the teeth are 3D imaged with the teeth closed in a clench to calibrate the sensor to the closed position, using graphic correlation.
  • any addition data from data sources (see see 461.-470, 472 and 473, FIG. 10) is collected and correlated with the 3D image data taken during processing associated with blocks 464 and 408.
  • the data collected and correlated, during processing associated with block 410 is employed, to generate 3D, physiologic and anatomic data.
  • Durin processing associated with an "Employ Analytic Tools for Evaluation of Data” block 414 the data collected and correlated during processing associated with block 410 and the data generated during processing associated with block 412 are evaluated to determine possible treatment plans.
  • a treatment plan identified during processing associated with block 414 is selected.
  • processing proceeds to an "End Develop Plan” block 419 in which process 400 is complete.
  • FIGURE 10 is a flowchart of an " ' implement Treatment" proces that incorporate aspect of the claimed subject matter.
  • aspects of process 450 are associated with logic stored on CRSM 362 (FIG * 8) in conjunction with DOS 366 (FIG, 8) and executed o one of more processors (not shown) of CPU 354 (FIG. 8) of computing system 352 (FIG. 8).
  • a user interface (not shown) is generated to display the data collected during processing associated with block 454.
  • the rendering of data is comprehensively displayed to show a real-time or time-stamp correlation that allows one to see a anatomic model of jaw/teeth 100 (FIG. 1-3) in function.
  • the user interface has diagnostic tools in the visualization rendering to aid in determining the correct eraniomandtbutar relationship with six (6) degrees of freedom.
  • a CAD/CAM treatment solution is designed then fabricated either in office or in a lab with milling tools 376 (FIG, 8) or 3D printer 374 (FIG, 8).
  • Treatment appliances may treat headaches, orthodontics, sleep apnea, TM.i dysfunctions and to prevent wear from grinding of the teeth.
  • a "Determine Tooth Structure Removal" block 478 an exact and precalculated area of tooth structure to remove t achieve an ideal bite may be calculated.
  • Augmented reality eyewear such as ARE 378 (FIG, 8) may displa an overlay of a digital treatment plan, including the visualization of tooth structure needed to be removed to achieve a desired shape of the tooth.
  • the graphical display may appear within the eyewear over actual teeth to guide treatment.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pathology (AREA)
  • Dentistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Human Computer Interaction (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

L'invention concerne des capteurs de position préalablement étalonnés et un service basé sur un ordinateur ou un nuage qui sont utilisés pour représenter en temps réel le mouvement des dents et des mâchoires présentant six degrés de liberté. L'ordinateur reçoit des images 3D anatomiquement correctes de n'importe quelle partie du système cranio-mandibulaire avec un ou plusieurs capteurs de position fixés. Les données de capteur de position sont ensuite transférées avec des fixations sans fil au patient pour générer un mouvement réaliste des modèles 3D numériques des dents et des mâchoires. Les modèles 3D sont alors utilisés pour obtenir diverses techniques de traitement des troubles de la morsure.
EP15858010.0A 2014-11-06 2015-11-05 Imagerie en trois dimensions du mouvement des dents et des mâchoires Withdrawn EP3216010A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462075934P 2014-11-06 2014-11-06
PCT/US2015/059340 WO2016073792A1 (fr) 2014-11-06 2015-11-05 Imagerie en trois dimensions du mouvement des dents et des mâchoires

Publications (2)

Publication Number Publication Date
EP3216010A1 true EP3216010A1 (fr) 2017-09-13
EP3216010A4 EP3216010A4 (fr) 2018-05-30

Family

ID=59520031

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15858010.0A Withdrawn EP3216010A4 (fr) 2014-11-06 2015-11-05 Imagerie en trois dimensions du mouvement des dents et des mâchoires

Country Status (1)

Country Link
EP (1) EP3216010A4 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110147647A (zh) * 2019-06-15 2019-08-20 广西科技大学 基于颞下颌关节稳定性的牙颌骨三维数字建模方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100571623C (zh) * 2004-03-31 2009-12-23 独立行政法人科学技术振兴机构 活体内三维运动测定装置及其方法
DE102006004197A1 (de) * 2006-01-26 2007-08-09 Klett, Rolf, Dr.Dr. Verfahren und Vorrichtung zur Aufzeichnung von Körperbewegungen
US20120115107A1 (en) * 2010-11-04 2012-05-10 Adams Bruce W System and method for automated manufacturing of dental orthotics

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110147647A (zh) * 2019-06-15 2019-08-20 广西科技大学 基于颞下颌关节稳定性的牙颌骨三维数字建模方法

Also Published As

Publication number Publication date
EP3216010A4 (fr) 2018-05-30

Similar Documents

Publication Publication Date Title
US12004867B2 (en) Three dimensional imaging of the motion of teeth and jaws
US9922454B2 (en) Method for designing an orthodontic appliance
JP6775621B2 (ja) 3dモデルを作成するためのデータを人から取得するための方法及びシステム
US8620045B2 (en) System , method and article for measuring and reporting craniomandibular biomechanical functions
US20120115107A1 (en) System and method for automated manufacturing of dental orthotics
JP5676325B2 (ja) 情報処理装置、情報処理方法、及びプログラム
EP3641653B1 (fr) Procédé d'enregistrement du mouvement et de la géométrie de l'articulation temporo-mandibulaire
Röhrle et al. Using a motion‐capture system to record dynamic articulation for application in CAD/CAM software
Woodford et al. Measurement of normal and pathological mandibular and temporomandibular joint kinematics: A systematic review
KR101573747B1 (ko) 덴탈 정보 제공방법, 덴탈 정보 제공시스템 및 컴퓨터로 읽을 수 있는 기록매체
Rosati et al. The occlusal plane in the facial context: inter-operator repeatability of a new three-dimensional method
Aslanidou et al. The fabrication of a customized occlusal splint based on the merging of dynamic jaw tracking records, cone beam computed tomography, and CAD-CAM digital impression
Baltali et al. A method for quantifying condylar motion in patients with osteoarthritis using an electromagnetic tracking device and computed tomography imaging
EP3216010A1 (fr) Imagerie en trois dimensions du mouvement des dents et des mâchoires
Verdenik et al. Three-dimensional facial changes correlated with sagittal jaw movements in patients with class III skeletal deformities
US20110191083A1 (en) System and Method for Measuring and Reporting the Relative Functions of Dental Anatomical Structures
Palomo et al. 3D Cephalometry
Jakubowska et al. Jaw motion tracking systems–literature review
Patel et al. Surgical planning: 2D to 3D
Gözler JVA, mastication and digital occlusal analysis in diagnosis and treatment of temporomandibular disorders
Cha Clinical application of three-dimensional reverse engineering technology in orthodontic diagnosis
CMO MULTI-DIMENSIONAL DIAGNOSIS & TREATMENT TO AVOID ORTHODONTIC & SURGICAL PITFALLS
Naser-ud-Din Analysis and correlation study of human masseter muscle with EMG, ultrasonography & 3D imaging.
Naser-Ud-Din Alternatives to Radiation Investigations in Orthodontics
Chan Gneuromuscular (GNM)

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20170602

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20180426

RIC1 Information provided on ipc code assigned before grant

Ipc: A61B 6/14 20060101ALI20180420BHEP

Ipc: A61F 5/56 20060101ALI20180420BHEP

Ipc: A61B 5/06 20060101ALI20180420BHEP

Ipc: A61B 5/11 20060101ALI20180420BHEP

Ipc: G06T 15/00 20110101AFI20180420BHEP

Ipc: A61B 5/00 20060101ALI20180420BHEP

Ipc: A61B 5/055 20060101ALI20180420BHEP

Ipc: A61B 5/0205 20060101ALI20180420BHEP

Ipc: A61C 7/00 20060101ALI20180420BHEP

Ipc: A61C 19/045 20060101ALI20180420BHEP

Ipc: A61B 8/08 20060101ALI20180420BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

R17P Request for examination filed (corrected)

Effective date: 20170602

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20220601