EP3207252B1 - Hose pump and device for analysing a chemical or biological sample - Google Patents

Hose pump and device for analysing a chemical or biological sample Download PDF

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Publication number
EP3207252B1
EP3207252B1 EP15790845.0A EP15790845A EP3207252B1 EP 3207252 B1 EP3207252 B1 EP 3207252B1 EP 15790845 A EP15790845 A EP 15790845A EP 3207252 B1 EP3207252 B1 EP 3207252B1
Authority
EP
European Patent Office
Prior art keywords
hose
planetary gear
gear
pump
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP15790845.0A
Other languages
English (en)
French (fr)
Other versions
EP3207252A1 (de
Inventor
Jochen Keuschnig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curetis GmbH
Original Assignee
Curetis GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curetis GmbH filed Critical Curetis GmbH
Publication of EP3207252A1 publication Critical patent/EP3207252A1/de
Application granted granted Critical
Publication of EP3207252B1 publication Critical patent/EP3207252B1/de
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/1223—Machines, pumps, or pumping installations having flexible working members having peristaltic action the actuating elements, e.g. rollers, moving in a straight line during squeezing
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/1253—Machines, pumps, or pumping installations having flexible working members having peristaltic action by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing

Definitions

  • the invention relates to a hose pump.
  • the invention also relates to a device or a system having such a hose pump and, especially, to a device or system for analysing a chemical or biological sample, in particular a sample of biological origin, e.g. a biological sample comprising nucleic acids.
  • the invention furthermore, relates to the field of "lab-on-the-chip" technology suitable for "in-field” and “point-of-care” (POC) applications.
  • a device for analysing a sample comprising at least one depot chamber and at least one process chamber, is known, whereas the process chamber is integrated in at least one first support member and the depot chamber is integrated in at least a second support member, whereas the support members are arranged in that the process chamber is connectable with the depot chamber by a relative movement of the first and second support members with respect to each other.
  • the device has a pump element for transferring the substances inside the device from one chamber to another, said pump element being integrated in one of the support members.
  • NAT lab-processed nucleic acid testing
  • Most of the NAT-based platforms and technologies currently under development do not provide an integrated solution for sample preparation, analysis, and data evaluation.
  • An example of a successful platform is known from WO 2005/106040 A2 .
  • Said device requires manual loading of reagents which can be inconvenient for the user and error-prone.
  • the data evaluation requires operator intervention. It is, therefore, inappropriate for in-field testing.
  • the complex lab-in-a-box design of the device which consists of several large injection moulded parts and further several mounting parts such as filters, screws, and nuts, etc., results in high costs for the disposable device.
  • a hose pump that can be produced in a cost efficient manner, but especially a hose pump that operates in a reliable manner, is beneficial.
  • the problem to be solved by the invention is to propose a hose pump that can be produced in a cost efficient manner, but, especially, a hose pump that operates in a reliable manner is beneficial.
  • the invention is based on the general idea of using the planetary gear of a planetary gear rack as rollers for the hose pump.
  • Planetary gears in planetary gear racks take up precisely definable positions within the ring gear during a circulation of the planetary gear around the sun gear. This allows the precise controlling of the amount of fluid being pumped by the hose pump.
  • planetary gear racks can be produced in a cost efficient manner, which allows for the hose pump as such to be produced in a cost-efficient manner.
  • a portion of the hose is arranged in the form of a ring segment.
  • the tooth of the planetary gear engages the hose in this hose portion.
  • several teeth of the planetary gear are made to engage the hose in one moment of time.
  • the planetary gear rolls along the hose portion.
  • that has the planetary gear roll along the hose portion after the first tooth has engaged with the hose for the first time of this cycle until the last tooth disengages from the hose for this cycle at all other times of engagement of teeth of the planetary gear with the hose at least one tooth of the planetary gear is in engagement with the hose at the same moment in time.
  • the planetary gear has a circumferential shape that is defined by the teeth, the planetary gear will act like a roller on the hose, the gap between the tips of the teeth being spanned by the hose.
  • the tips of the teeth of a planetary gear are flattened. This, on the one hand, reduces the gap between the teeth, and, thus, what needs to be spanned by the hose.
  • flattened teeth or teeth with a roof ridge with large internal ridge angle reduce the wear on the hose.
  • the tips of the teeth can have an anti-slip effect to prevent the slipping of the planetary gear as it rolls along the hose.
  • the planetary gear rack has more than three planetary gears, especially preferred more than four planetary gears, and especially preferred more than five or equal to five planetary gears.
  • At least one of the teeth of at least one of the planetary gear of the planetary gear rack is in engagement with the hose to squeeze a portion of the hose. This prevents the fluid in the hose from flowing backwards.
  • the valve would be closed to prevent backflow of the fluid as the tooth of the planetary gear comes into disengagement with the hose. If, however, as described above, the hose pump is designed in such a manner that at least one tooth of at least one of the planetary gears of the planetary gear rack is in engagement with the hose to squeeze a portion of the hose, in all operational conditions, such a valve can be done away with, because the tooth squeezing the hose portion can be used to prevent or reduce the back flow of the fluid.
  • the term “squeeze” is to be understood to mean that the hose portion is squeezed in such a manner that the channel within the hose is closed for a portion of its extent. Closing the channel within the hose fully prevents fluid flow past the portion that is being squeezed.
  • the advantages of the invention (possibly to a lesser extent) will, however, also be reached if in an alternative embodiment the term “squeeze” is understood in such a sense that the engagement of the tooth with the hose closes the channel within the hose only partially.
  • the remaining gap theoretically allows for a backflow of fluid past the portion of the hose being squeezed. It is, however, to be expected that the flow resistance in this portion of the hose is substantially increased, which reduces the amount of fluid that flow back past the portion of the hose being squeezed.
  • the hose pump has a support surface; the portion of the hose being squeezed between the tooth of the planetary gear and the support surface.
  • the support surface has a bent shape.
  • the hose is in contact with the bent support surface such that the portion of the hose that is in contact with the support surface takes up the shape of a ring segment. This provides a good design that allows the planetary gear of the planetary gear rack to roll along this hose section while squeezing a portion of the hose against a portion of the support surface.
  • the ring gear of the planetary gear rack is a ring segment, whereby the ring gear instead of a further ring segment that would complete the ring gear to a ring has an opening, a portion of the hose being arranged inside this opening.
  • This design allows for an easy way to bring the planetary gear of the planetary gear rack into engagement with the hose in order to squeeze a portion of the hose.
  • the ring segment of the ring gear spans over more than 180°. It is to be expected that the stability and precision of the movement of the planetary gear that engages the hose portion is also affected by the stability of a cage of the planetary gear rack that holds the planetary gear.
  • the stability of the cage of the planetary gear rack can be increased in an embodiment, where at least two planetary gears are provided as part of the planetary gear rack and at least one of the planetary gears is in engagement with the ring gear. This can be achieved by having the ring gear span over more than 180 °.
  • the enclosure angle would thus be 180° and the opening of the ring segment of the ring gear would span more than 180°.
  • the enclosure angle would be 120° and the opening of the ring gear of such an embodiment would span, preferably, over more than 120 °.
  • a portion of the hose is arranged inside the opening with the shape of a ring segment that spans over at least 40 %, preferably over at least 50 %, especially preferred over 75 % of the angle that the ring gear has an opening rather than a ring segment. The more opening is taken up by the portion of the hose, the more the rotational movement of the planetary gear around the sun gear can be used for pushing the fluid inside the channel of the hose along the channel.
  • the size of the opening in the embodiment where the ring gear has an opening correlates to the number of planetary gears of the planetary gear rack in such a manner that for the majority of the time only one planetary gear of the planetary gear rack is in engagement with a portion of the hose.
  • the next planetary gear comes into engagement with the hose in order to prevent or reduce the flow back of fluid. This can be achieved if the angle over which the portion of the hose spans in the shape of a ring segment is equal to or a little bit larger than the enclosure angle. In such an embodiment, the segment of the ring would need to span over less than (360° minus the enclosure angle).
  • the planetary gear in the direction of its rotational axis extends over the ring gear, whereby the portion of the planetary gear that extends over the ring gear engages into the hose to squeeze a portion of the hose.
  • the hose can be arranged next to the ring gear, and the ring gear can be designed to be a complete ring. This would allow for a planetary gear of the planetary gear rack to be in engagement with a portion of the hose while the planetary gear at the same time is in engagement with the ring gear. This can further stabilize the positioning of the planetary gear as it is in engagement with the hose.
  • a portion of the hose is arranged in the shape of a ring segment with the same radius as the ring gear, and is arranged next to the ring gear such that the portion of the planetary gear that extends over the ring gear comes into contact with the portion of the hose.
  • a position sensor is arranged at the planetary gear or at the cage to determine the rotational position of the planetary gear in the planetary gear rack. Knowledge about the rotational position of the planetary gear within the planetary gear rack allows for a better control of the pumping action of the hose pump.
  • the device according to the invention has at least one depot chamber and at least one process chamber, whereas the process chamber is integrated in at least one first support member and the depot chamber is integrated in at least a second support member, whereas the support members are arranged in that the process chamber is connectable with the depot chamber by a relative movement of the first and second support members with respect to each other, the device further comprising a pump element for transferring the substances inside the device from one chamber to another.
  • the device has as pump element a hose pump according to the invention.
  • system according to the invention has a hose pump according to the invention or a device according to the invention and a base station, said base station comprising at least a pump drive which acts on the hose pump to drive the planetary gear around the sun gear, for example by driving the sun gear.
  • the cage holding the planetary gear could be driven.
  • the hose pump or the device is detachably connected to the base station.
  • This allows, for example for the drive of the planetary gear to be made part of the base.
  • the term "hose pump” according to the invention is to be understood in such a sense that it also refers to embodiments without a drive for the planetary gear.
  • the planetary gear rack has more than two planetary gears.
  • the planetary gear rack has six or less than six planetary gears.
  • the device for analysing a sample provides a simple and incomplex design, and in particular a design which can be inexpensively produced.
  • the invention also provides a device which suitably allows the use as a "disposable", i.e. a lab-on-a-chip which is disposed after use.
  • the device of the invention is particularly suitable for in-field and point-of-care settings.
  • the pump element into the device itself, all elements which will contact the substances during analysis are combined in a - preferably disposable - unit, which allows for the creation of a closed fluidic system, which helps preventing any contamination of the substances or the interior of the device itself. Such contamination may occur when the device would have to be connected to an "exterior" pump.
  • the chamber of the device can be pre-filled with reagents adapted to perform a distinct analysis. Therewith, the device can be used as a "ready-to-use" format of a lab on a chip.
  • the sample analysed in the device of the invention can be of any origin or nature, for example of biological, natural, synthetic or semi-synthetic origin.
  • the invention thus, is not limited to any specific sample origin.
  • an elastic hose may be provided as part of the pump element.
  • the elastic hose may be connected to the chambers by respective conduits, which are integrated into the support members.
  • a pumping pressure may be created inside the elastic hose by locally deforming and thereby reversibly sealing it, for example by means of a roller element, which is moved along the length of the elastic hose This creates a positive pressure inside the elastic hose on the side of the roller element which faces in the direction of movement. Consequently, a negative pressure is created on the opposite side inside the elastic hose.
  • the pump element of the device comprises an elastic hose and the pump drive of the base station comprises a deformation element, preferably a roller element, which is moved along the length of the elastic hose, thereby locally deforming the elastic hose.
  • a deformation element preferably a roller element
  • the system according to the invention may further comprise at least one heating means.
  • Said heating means may generate different temperature zones in the base station.
  • the base station may comprise a drive by which said temperature zones are movable with respect to the device.
  • the temperatures inside the different chambers of the device may be adjusted to values which are best suited for the respective process steps carried out inside said chambers. This allows generating a temperature profile which is adapted to the successive process steps being conducted within the analysing device.
  • the ring gear is a ring segment.
  • the ring gear (4) has an opening (9).
  • a portion of the hose (2) is arranged inside this opening (9).
  • the opening spans over an angle ⁇ that in the embodiment shown in the fig. is approximately 115°. Consequently, the ring segment of the ring gear spans over an angle of 245° (360°- ⁇ ).
  • the hose pump (1) is provided with a support surface (10) that has a bent shape. This allows the portion of the hose (2) that is in contact with the support surface (10) to take up the shape of a ring segment. This ring segment spans over an angle ⁇ of approximately 90 °.
  • the enclosure angle in the embodiment shown in the fig. which has five planetary gears of the planetary gear rack, is 72°.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Reciprocating Pumps (AREA)

Claims (11)

  1. Schlauchpumpe (1) mit einem Schlauch (2) zum Aufnehmen der zu pumpenden Flüssigkeit, und mit einem Planetengetriebe-Rack (3), das ein Hohlrad (4), ein Sonnenrad (5) und mindestens zwei Planetenräder (6) aufweist, die zwischen dem Hohlrad (4) und dem Sonnenrad (5) liegen,
    dadurch gekennzeichnet, dass
    mindestens einer der Zähne (7) der mindestens zwei Planetenräder (6) während eines Zyklus der mindestens zwei Planetenräder (6) um das Sonnenrad (5) mindestens einmal in den Schlauch (2) eingreift, um einen Teil des Schlauchs (2) zu quetschen.
  2. Schlauchpumpe nach Anspruch 1, gekennzeichnet durch eine Stützfläche, wobei der Teil des Schlauchs (2) zwischen dem Zahn (7) des Planetenrades (6) und der Stützfläche (10) gequetscht wird.
  3. Schlauchpumpe nach Anspruch 1 oder 2, dadurch gekennzeichnet, dass das Hohlrad (4) ein Ringsegment ist und dass das Hohlrad (4), anstelle eines weiteren Ringsegments, das das Hohlrad (4) zu einem Ring komplettieren würde, eine Öffnung (9) aufweist, wobei ein Teil des Schlauchs (2) innerhalb dieser Öffnung (9) angeordnet ist.
  4. Schlauchpumpe nach Anspruch 3, dadurch gekennzeichnet, dass das Ringsegment des Hohlrades (4) mehr als 180° aufspannt.
  5. Schlauchpumpe nach Anspruch 3 oder 4, dadurch gekennzeichnet, dass das Ringsegment des Hohlrades (4) weniger aufspannt, als ein Winkel, der berechnet ist durch 360° minus einen Umschließungswinkel, wobei der Umschließungswinkel berechnet wird durch die Formel:
    Umschließungswinkel = 360° / Anzahl der Planetenräder (6) des Planetengetriebe-Racks (3).
  6. Schlauchpumpe nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, dass sich das Planetenrad in der Richtung seiner Rotationsachse über das Hohlrad erstreckt, und dass der Teil des Planetenrades, der sich über das Hohlrad erstreckt, in den Schlauch eingreift, um einen Teil des Schlauchs zu quetschen.
  7. Schlauchpumpe nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, dass ein Positionssensor an dem Planetenrad oder an dem Käfig angeordnet ist, um die Rotationsposition des Planetenrades in dem Planetengetriebe-Rack festzustellen.
  8. Vorrichtung zum Analysieren einer Probe, wobei die Vorrichtung mindestens eine Depotkammer und mindestens eine Prozesskammer umfasst, wobei die Prozesskammer in mindestens ein erstes Stützelement integriert ist und die Depotkammer in mindestens ein zweites Stützelement integriert ist, wobei die Stützelemente so angeordnet sind, dass die Prozesskammer mit der Depotkammer durch eine Relativbewegung der ersten und zweiten Stützelemente in Bezug zueinander verbindbar ist, wobei die Vorrichtung ferner ein Pumpenelement zum Transferieren der Substanzen innerhalb der Vorrichtung von einer Kammer zu einer anderen umfasst,
    dadurch gekennzeichnet, dass das Pumpenelement eine Schlauchpumpe (1) nach einem der Ansprüche 1 bis 7 ist.
  9. System, das umfasst:
    - eine Schlauchpumpe (1) nach einem der Ansprüche 1 bis 7 oder eine Vorrichtung nach Anspruch 8
    - eine Basisstation, wobei die Basisstation mindestens einen Pumpenantrieb umfasst, der an der Schlauchpumpe (1) wirkt, um das Planetenrad um das Sonnenrad zu treiben.
  10. System nach Anspruch 9, dadurch gekennzeichnet, dass die Schlauchpumpe nach einem der Ansprüche 1 bis 7 oder die Vorrichtung nach Anspruch 8 abnehmbar mit der Basisstation verbunden ist.
  11. Verwendung der Schlauchpumpe (1) nach einem der Ansprüche 1 bis 7 oder der Vorrichtung nach Anspruch 8 oder des Systems nach Anspruch 9 oder 10 auf dem Gebiet der Point-of-Care-Anwendungen, insbesondere auf dem Gebiet der Nukleinsäure-Analyse.
EP15790845.0A 2014-10-14 2015-10-09 Hose pump and device for analysing a chemical or biological sample Not-in-force EP3207252B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14188850.3A EP3009679A1 (de) 2014-10-14 2014-10-14 Schlauchpumpe und Vorrichtung zur Analyse einer chemischen oder biologischen Probe
PCT/EP2015/073382 WO2016058926A1 (en) 2014-10-14 2015-10-09 Hose pump and device for analysing a chemical or biological sample

Publications (2)

Publication Number Publication Date
EP3207252A1 EP3207252A1 (de) 2017-08-23
EP3207252B1 true EP3207252B1 (de) 2018-12-12

Family

ID=51703028

Family Applications (2)

Application Number Title Priority Date Filing Date
EP14188850.3A Withdrawn EP3009679A1 (de) 2014-10-14 2014-10-14 Schlauchpumpe und Vorrichtung zur Analyse einer chemischen oder biologischen Probe
EP15790845.0A Not-in-force EP3207252B1 (de) 2014-10-14 2015-10-09 Hose pump and device for analysing a chemical or biological sample

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP14188850.3A Withdrawn EP3009679A1 (de) 2014-10-14 2014-10-14 Schlauchpumpe und Vorrichtung zur Analyse einer chemischen oder biologischen Probe

Country Status (7)

Country Link
US (1) US20170306942A1 (de)
EP (2) EP3009679A1 (de)
JP (1) JP2017531132A (de)
CN (1) CN107076136A (de)
CA (1) CA2962128A1 (de)
ES (1) ES2704116T3 (de)
WO (1) WO2016058926A1 (de)

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JPS6026295U (ja) * 1983-07-28 1985-02-22 株式会社島津製作所 しごきポンプ装置
DE4031554A1 (de) * 1990-02-23 1991-08-29 Standard Elektrik Lorenz Ag Schlauchpumpe
US5871341A (en) * 1996-12-31 1999-02-16 Melody; Brian J. Peristaltic pump driven pump roller apparatus and methodology
JP2001227476A (ja) * 2000-02-15 2001-08-24 Yutaka Sonoda 倍速機構付チューブ式液圧ポンプ
WO2002025112A1 (en) * 2000-09-22 2002-03-28 Sorenson Technologies, Inc. Flexible tube positive displacement pump
US20050129545A1 (en) * 2003-12-15 2005-06-16 Prosek Michael E.Jr. Peristaltic pumping mechanism with geared occlusion rollers
US20050244837A1 (en) 2004-04-28 2005-11-03 Cepheid Method and device for sample preparation control
US7578662B1 (en) * 2005-11-18 2009-08-25 Araz Ibragimov Peristaltic pump having pumping and occluding rollers and alternating pumping systems utilizing thereof
DE102005061331A1 (de) * 2005-12-21 2007-06-28 Vmi-Az Extrusion Gmbh Fördervorrichtung
US20080056912A1 (en) * 2006-08-31 2008-03-06 Pizzichil William P Pump system and method using planetary gear assembly
EP2036585A1 (de) * 2007-09-13 2009-03-18 Ulrich GmbH & Co. KG Rollenpumpe
EP2143491A1 (de) 2008-07-10 2010-01-13 Carpegen GmbH Vorrichtung zum Analysieren einer chemischen oder biologischen Probe
US8292604B2 (en) * 2009-05-01 2012-10-23 Xerox Corporation Peristaltic pump
DE102010000592B3 (de) * 2010-03-01 2011-06-16 Ulrich Gmbh & Co. Kg Schlauchpumpe mit Planetengetriebe
TWM434834U (en) * 2012-01-11 2012-08-01 Cheshire Electric Company Llc Precision quantity peristaltic pump and device thereof
JP6060337B2 (ja) * 2012-06-25 2017-01-18 国立大学法人大阪大学 チューブポンプ
GB2518806B (en) * 2013-06-26 2018-04-11 Intelligent Energy Ltd Pump assembly

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Title
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Also Published As

Publication number Publication date
CA2962128A1 (en) 2016-04-21
JP2017531132A (ja) 2017-10-19
US20170306942A1 (en) 2017-10-26
EP3009679A1 (de) 2016-04-20
EP3207252A1 (de) 2017-08-23
ES2704116T3 (es) 2019-03-14
WO2016058926A1 (en) 2016-04-21
CN107076136A (zh) 2017-08-18

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