EP3204096A1

EP3204096A1 - Nebulizer with stationary screen

Info

Publication number: EP3204096A1
Application number: EP15788144.2A
Authority: EP
Inventors: Laurent VECELLIO; Gilles Chantrel; Jean-Philippe MASSARDIER
Original assignee: La Diffusion Technique Francaise
Current assignee: La Diffusion Technique Francaise
Priority date: 2014-10-06
Filing date: 2015-10-05
Publication date: 2017-08-16
Also published as: FR3026646A1; FR3026646B1; WO2016055723A1

Abstract

The present invention relates to a nebulizer comprising at least one tank (6) for containing a liquid, wherein said tank (6) comprises an opening (O) on the outer surface thereof for pouring said liquid into the tank (6); a stationary screen (2) comprising a plurality of microscopic holes, wherein one surface (2a) of the screen, in contact with the same liquid contained in the tank, is arranged opposite a piezoelectric device (1) that is in contact with same liquid contained in the tank (6) such that the vibrations of the piezoelectric device (1) are transmitted to the liquid, forcing same through the holes of the screen (2) to produce an aerosol from a so-called emitting surface (2b) of said screen. The opening (O) of the tank (6) intended for filling same in an operation position of said device, is located above the surface (2a) of the screen arranged horizontally in the operation position, and opposite the piezoelectric device (1), so as to produce, in said operation position, an aerosol along an axis of around 30 degrees in relation to the vertical, from top to bottom.

Description

FIXED TAMIS NEBULIZATION DEVICE

TECHNICAL FIELD The present invention relates to a medical aerosol generation system and more particularly to a fixed screen nebulization device avoiding any malfunctioning and any risk of contamination of the drug in particular.

PRIOR ART

It is well known medical aerosol generation systems whose function is to transform a drug in liquid or powder form into an aerosol to be administered in the respiratory airways of a patient. These nebulizer devices are used to deliver large quantities of various drugs directly into the patient's airways. They thus provide a rapid and selective therapeutic action at the level of the pathological site. It should be noted that nebulization can be defined as the transformation of a medicinal liquid into a medicinal aerosol. The term "nebulize" is used as a synonym for "turning a liquid into an aerosol".

Usually, a nebulizing apparatus comprises a reservoir into which the liquid to be sprayed is introduced, a nebulization chamber, where the aerosol is produced, and a pneumatic or piezoelectric energy source used to create the aerosol.

There are basically three principles of nebulization to produce a medicated aerosol: pneumatic nebulization, ultrasonic nebulization and more recently sieve nebulization. Sieve nebulizer systems have the advantage of being quiet, portable and small. They consist of an electronic power supply connected to the nebulizer. The electronic power supply can operate on mains or batteries. The aerosol generator is composed of a sieve pierced with a large quantity microscopic holes with a diameter of 2 μιη to 10 μιη, said holes being obtained by electrophoresis or by laser drilling of the sieve. The passage of the medicinal liquid through the sieve transforms the liquid into aerosol droplets of size equivalent to the size of the holes of said sieve.

Currently, there are two main types of screen aerosol generators, the fixed or static screen and the vibrating screen. The fixed screen aerosol generator uses a piezoelectric in contact with the medicinal liquid. The piezoelectric vibration (between 0HzHz and 500KHz) is transmitted to the liquid forcing its passage through the screen holes to detach breathable droplets out of the screen. The aerosol produced is then mobilized by the patient out of the nebulizer. In this type of fixed screen nebulizer, the piezoelectric is separated from the sieve. The vibrating screen aerosol generator uses a piezoelectric device surrounding the screen to vibrate it (between the OKHz and 500KHz). The drug solution then in contact with the sieve will be drawn through the conical holes as it deforms toward the solution reservoir. When the sieve will deform outward, the solution then located at the edge of the sieve will detach to form respirable particles. The aerosol is then mobilized by the patient out of the nebulizer. In this type of vibrating screen nebulizer, the piezoelectric is secured to the sieve.

For example, documents JPH08196965 of 1987 and US 6705312 which disclose a static screen nebulizer which is marketed by OMRON® are known. Referring to Figure 1 which is a schematic representation of a nebulizer according to the teaching of these documents, said nebulizer operates on the principle of the vibration of a cylindrical piezoelectric quartz (1), extending horizontally and pushing the liquid through a static sieve (2) which extends vertically and which is held by a hollow cylinder (3). The cylindrical piezoelectric quartz (1) is powered by an electrical signal with two pins (4) and (5). The liquid is placed in a tank (6) closed by an upper lid (7) and having a hopper-shaped upper part and a substantially parallelepipedal lower part, one of whose side walls receives the sieve (2) and whose wall opposite side receives the cylindrical piezoelectric quartz (1), the cylindrical end of the piezoelectric quartz is positioned near the sieve. When setting As the piezoelectric quartz works, quartz vibration causes the liquid to move from the base of the quartz cylinder to the opposite cylindrical end of the quartz and the liquid is pushed through the sieve (2). Micro droplets are thus ejected on the other side of the sieve (2).

Nebulizers sold by Kjump® are also known operating on the same principle as the nebulizer described in JP 4215765. With reference to Figure 2 which is a schematic representation of the nebulizer of the prior art, said nebulizer comprises a quartz piezoelectric (1) and a static sieve (2) respectively integral with the bottom wall and the upper wall of a substantially parallelepiped tank (6), said tank (6) being closed by an upper cover (7). The cylindrical piezoelectric quartz (1) is fed by an electrical signal with two pins (4) and (5), the free end of the piezoelectric quartz (1) is positioned within 2 mm of the static sieve (2). Thus, the nebulizer allows the generation of an aerosol along a vertical axis from bottom to top.

This type of static screen nebulizer, although of inexpensive design because of the dissociation of the sieve with piezoelectric quartz, has the disadvantage of operating only in a particular orientation, that is to say a generation. aerosol from bottom to top or horizontally. Thus, this type of nebulizer presents a risk of malfunction of the sieve. Indeed, if the patient saliva in the system, the saliva can come by gravity to be placed at the level of the sieve and prevent its operation by obstructing the holes of the sieve. The aerosol itself produced by the nebulizer can also be deposited on the aerosol transport circuits (tubing) and slide by gravity to come into contact with the screen and thus obstruct it. In addition, this type of nebulizer presents a risk of contamination of the drug. A liquid substance deposited on the outer side of the sieve due to slipping liquid (saliva, drug deposited in a circuit, moisture, etc.) can be transferred / pumped to the other side of the sieve (EP1875936) and thus be mixed in the nebulizer tank with the drug, contaminating it. Moreover, a different orientation of these nebulizers, so that the sieve is oriented downwards does not allow operation of these nebulizers. Indeed, the geometry of the tanks and the position of the lids do not allow a correct nebulization when said tanks are almost empty and respectively a loading of the tanks in liquid.

Vibrating screen nebulizers such as those marketed by the company Aerogen® and described in US patent application US 2003/150445 are also known. This document describes, with reference to FIG. 3, a nebulizer operating on the basis of the vibration of a sieve (2) set in motion by a piezoelectric quartz (1). The piezoelectric quartz (1) is annular in shape and surrounds the screen (2) placed at its center. The piezoelectric quartz (1) is powered by an electrical signal with two pins (4) and (5). The liquid is placed by an upper cover (7) in a reservoir (6) of the nebulizer which by gravity comes into contact with the top of the screen (2). When the screen (2) vibrates, the liquid is pumped through the screen and ejected from the other side of said screen. In this case the aerosol is produced from top to bottom and vertically. This principle of downward aerosol generation has the advantage of being adapted for use with inhalation chambers and of providing constant performance during the time of nebulization. Indeed, the use of a screen nebulizer projecting the aerosol in one direction can be followed by a loss on the walls. In this case the aerosol deposited on the walls will not flow to the sieve of the tank and will not obstruct the sieve and thus stop the nebulization.

This nebulization system nevertheless has the major disadvantage of a higher manufacturing cost than the static screen nebulizer. Indeed, the assembly of annular piezoelectric quartz and the sieve at its center poses complex manufacturing problems and associated costs not negligible.

SUMMARY OF THE INVENTION

One of the aims of the invention is therefore to overcome these disadvantages by providing a nebulization device of simple and inexpensive design, avoiding any dis operation and any contamination of the liquid to be sprayed.

For this purpose, and in a known manner, the nebulizing device comprises at least one reservoir capable of containing a liquid, said reservoir comprising an opening on its outer surface for pouring said liquid into the reservoir, a fixed screen comprising a plurality of microscopic holes and one side in contact with the liquid contained in the reservoir is disposed facing a piezoelectric device which is in contact with the same liquid contained in the reservoir so that the vibrations of the piezoelectric device are transmitted to the liquid forcing its passage through the screen holes to generate an aerosol, from a screen emission face.

According to the invention, in view of the problem to be solved, the opening of the reservoir for its filling in an operating position of said device is located above the sieve face arranged horizontally in the operating position and facing of the piezoelectric device, in order to produce, in said operating position, an aerosol along an axis of the order of 30 degrees relative to the vertical, from top to bottom.

It follows from these characteristics that the static screen nebulizer according to the invention produces an aerosol along a vertical axis from bottom to top. Unexpectedly, the liquid in contact with the sieve allows the direct nebulization of the liquid while the operating principle of the fixed screen nebulizers of the prior art theoretically requires the contact of the liquid at the base of the piezoelectric quartz to allow the Controlled feeding of the liquid to the screen to generate aerosol. It is also observed that air bubbles produced by the sieve in the liquid are evacuated by the face of the sieve disposed opposite the piezoelectric. Indeed, the vibration of the piezo not only causes a thrust of the liquid to the sieve but also a suction of the outside air through the sieve, thereby generating air bubbles in the tank. The invention is also remarkable in that the arrangement of the sieve facing the tank allows the natural evacuation of air bubbles by ascent. These air bubbles are not trapped against the sieve and do not prevent the passage of liquid through the sieve contrary to the arrangement as shown in Figure 2.

To ensure the liquid supply of the nebulizer to allow its generation, the tank has a frustoconical lower portion whose smallest base forms a lower opening which is closed by the sieve maintained on the underside of said tank to the right of said lower opening by a lower cylindrical piece.

The frustoconical section of the tank base minimizes the residual volume of liquid in the tank, at the end of nebulization.

Advantageous results are obtained when the piezoelectric device consists of a vertical piezoelectric cylinder extending inside the frustoconical lower part of the tank, at right of the sieve, perpendicular to said sieve and at a maximum distance of 2 mm. of the last.

In addition, the holes of the sieve have a diameter of between 1 and 10 μιη.

In addition, said screen comprises between 100 and 10,000 holes. Preferably, the reservoir has a form of revolution comprising a cylindrical upper portion having a central cylindrical recess and a frustoconical lower portion.

Said piezoelectric cylinder extends coaxially with the axis of revolution of the reservoir.

Furthermore, the device comprises a control circuit of the piezoelectric device adapted to vibrate said piezoelectric cylinder at a frequency between 10 and 500 KHz.

Incidentally, the lower cylindrical piece is integral with the upper wall of an interface consisting of a container comprising a bottom wall, at least one side wall, an upper wall, and a mouthpiece or face mask, said lower cylindrical piece opening in the container whose upper wall is equipped with a vent.

The tip consists of a mouthpiece or a nosepiece. According to another alternative embodiment, the device comprises a respirator comprising an inspiration line and an exhalation line connected to a flexible intubation probe by a Y-shaped piece, said inspiratory line and / or the the end of the Y-shaped part comprises a bypass pipe adapted to receive the lower cylindrical part so that, during the inspiratory phases, the aerosol is projected into the inspiration pipe and / or the Y-shaped piece. .

SUMMARY DESCRIPTION OF THE FIGURES Other advantages and features will become more apparent from the following description of a single variant embodiment, given by way of non-limiting example, of the invention according to the attached drawings in which: :

FIG. 1 is a schematic representation of a fixed screen nebulizer of the prior art,

FIG. 2 is a schematic representation of a second fixed screen nebulizer of the prior art,

FIG. 3 is a schematic representation of a vibrating screen nebulizer of the prior art,

FIG. 4 is a schematic representation of a fixed screen nebulizer according to the invention,

FIG. 5 is a schematic representation of a first variant embodiment of the fixed screen nebulizer according to the invention,

FIG. 6 is a diagrammatic representation of a detail of the first embodiment variant of the fixed screen nebulizer according to the invention,

- Figure 7 is a schematic representation of a second embodiment of the fixed screen nebulizer according to the invention.

DETAILED DESCRIPTION OF THE INVENTION

Hereinafter, a nebulizing device is described which is particularly intended for medical aerosol generation systems whose function is to transform a medicament in liquid form into an aerosol to be administered in the tracts. respiratory air of a patient; however, it is obvious that the nebulizing device can find many applications in other technical fields without departing from the scope of the invention. For the sake of clarity, in the remainder of the description, the same elements have been designated by the same references in the various figures. In addition, the various sectional views are not necessarily drawn to scale and the dimensions of the elements may have been exaggerated to facilitate the understanding of the invention. With reference to FIG. 4, the nebulizing device according to the invention comprises a reservoir (6) able to contain a liquid, such as a medicament for example, said reservoir (6) having an upper opening (O) for the pouring said liquid into the reservoir (6) and a fixed screen (2) comprising a plurality of microscopic holes. One of the faces (2a) of the sieve (2) is arranged facing a piezoelectric device (1) in contact with the liquid contained in the reservoir (6) so that the vibrations of the piezoelectric device (1) are transmitted to the liquid forcing its passage through the holes of the sieve (2) to generate an aerosol, from an emission face (2b) of the sieve According to the invention, the opening (O) of the reservoir (6) for its filling in an operating position of said device, is arranged facing the piezoelectric device (1), in order to produce, in said operating position, an aerosol along a substantially vertical axis, of the order of 30 degrees, from top to bottom. Advantageously, said reservoir (6) comprises a frustoconical lower part

(6a) whose smaller base forms the lower opening which is closed by the sieve (2) maintained on the underside of said tank (6) at the right of said lower opening by a lower cylindrical piece (3). The reservoir (6) has a shape of revolution comprising a cylindrical upper part (6b) having a central cylindrical recess (6c), said central recess (6c) being coaxial with the upper part (6b) and a frustoconical lower part (6a) whose vertical axis of revolution is coaxial with the axis of revolution of the upper part (6b) of the tank. Moreover, the upper opening (O) of the upper part (6b) of the reservoir (6) which has an annular shape has a cover (7) adapted to close said opening and allowing its opening and closing repeated to ensure the charging of the reservoir (6) in liquid.

The piezoelectric device (1) consists of a vertical piezoelectric cylinder extending inside the frustoconical lower part (6a) of the reservoir (6), at the sieve (2) and perpendicular to said sieve (2). ). The lower end of said piezoelectric cylinder (1) extends at a maximum distance of 2 mm from said screen (2). The axis of the piezoelectric cylinder (1) is substantially coaxial with the axis of revolution of the lower part (6a) and the upper part (6b) of the reservoir (6). The piezoelectric cylinder (1) is powered by an electrical signal by means of two pins (4) and (5) which extend above the lower part (6a) of the tank (6), on the inside the central cylindrical recess (6c). Furthermore, said sieve (2) is substantially circular and has a plurality of holes, between 100 and 10000 holes, whose diameter is between 1 and 10 μιη, said holes being obtained in a well-known manner by electrophoresis or by laser drilling. sieves in particular.

Thus, after introducing a liquid into the tank (6) via the cover (7), said liquid is directed by gravity on the screen (2). The frustoconical lower portion (6a) ensures liquid flow from the top of the tank (6) to the sieve (2). During the operation of the piezoelectric cylinder (1), the vibration of the cylinder causes the liquid to move through the screen (2) from its face (2a). Micro droplets are thus ejected from the emission face (2b) of the sieve (2) along a vertical axis from top to bottom. The nebulization device according to the invention combines the advantages of a low cost of production and performance while limiting the risks associated with the flow of liquid on the screen. In addition, unexpectedly, the liquid in contact with the screen (2) allows the direct nebulization of the liquid even when the piezoelectric cylinder (1) is not in contact with the liquid while the static screen nebulizers of the prior art theoretically requires contact of the liquid with the lower end of the piezoelectric cylinder (1) to allow controlled feeding of the liquid to the screen to generate aerosol.

According to a first alternative embodiment of the nebulizing device according to the invention, not shown in the figures, said device comprises, in the same way than previously, a reservoir (6) adapted to contain a liquid, said reservoir (6) comprising an upper opening for pouring said liquid into the reservoir (6), a screen (2) comprising a plurality of microscopic holes and a piezoelectric device (1) in contact with the liquid contained in the reservoir (6). Said reservoir (6) comprises an inclined lower part (6a) in the direction of the lower opening which is closed by the sieve (2) maintained on the lower face of said reservoir (6) in line with said lower opening by a lower cylindrical part (3). The upper part (6b) of the reservoir is substantially cylindrical. The piezoelectric device (1) consists of a vertical piezoelectric cylinder extending inside the frustoconical lower part (6a) of the reservoir (6), at the sieve (2) and perpendicular to said sieve (2). ). The lower end of said piezoelectric cylinder (1) extends at a maximum distance of 2 mm from said sieve (2) and the axis of the piezoelectric cylinder (1) is substantially coaxial with the axis of revolution of the lower part (6a) of the tank (6). The piezoelectric cylinder (1) is powered by an electrical signal by means of two pins (4) and (5) which extend above the lower part (6a) of the tank (6), along the side wall of the cylindrical upper portion (6b) of said reservoir (6).

In this embodiment, the opening of the reservoir (6) is offset laterally relative to the sieve assembly (2) - piezoelectric device (1). In other words, this variant of execution differs from that previously described in that the upper part (6b) of the tank is substantially cylindrical and contains no recess, the vertical axis of revolution of the upper part (6b) extending parallel to the vertical axis of revolution of the lower portion (6a) of the reservoir (6) receiving the sieve (2) being offset.

Furthermore, the upper opening of the upper part (6b) of the tank (6) which has a circular shape comprises a disk-shaped lid (7) adapted to close said opening and allowing its repeated opening and closing to ensure loading the reservoir (6) with liquid. According to a second alternative embodiment of the nebulizing device according to the invention, with reference to FIGS. 5 and 6, said device comprises, in the same manner as above, a reservoir (6) adapted to contain a liquid, said reservoir (6 ) comprising an upper opening (O) for pouring said liquid into the reservoir (6), a sieve (2) comprising a plurality of microscopic holes and a piezoelectric device (1) in contact with the liquid contained in the reservoir (6). Said reservoir (6) comprises a frustoconical lower portion (6a) whose smallest base forms the lower opening which is closed by the sieve (2) maintained on the lower face of said reservoir (6) in line with said lower opening by a lower cylindrical part (3). The upper part (6b) of the reservoir is substantially cylindrical. The piezoelectric device (1) consists of a vertical piezoelectric cylinder extending inside the frustoconical lower part (6a) of the reservoir (6), at the sieve (2) and perpendicular to said sieve (2). ). The lower end of said piezoelectric cylinder (1) extends at a distance of at most 2 mm from said screen (2) and the axis of the piezoelectric cylinder (1) is substantially coaxial with the axis of revolution the lower part (6a) of the tank (6). The piezoelectric cylinder (1) is powered by an electrical signal by means of two pins (4) and (5) which extend above the lower part (6a) of the tank (6), along the side wall of the cylindrical upper portion (6b) of said reservoir (6).

In the alternative embodiment illustrated in FIGS. 5 and 6, the device is distinguished in that it comprises a respirator (8) comprising an inspiration line (9) and an exhalation line (10) connected to a probe flexible intubation (11) by a Y-shaped piece (12), said inspiratory pipe (9) having a T-shaped bypass duct (13) adapted to receive the lower cylindrical piece (3) so that during the inspiratory phases, the aerosol is projected into the inspiration pipe (9). Thus, during the inspiratory phases of the respirator, the aerosol produced is transported through the inspiration pipe (9), the Y-piece (12) and the probe (11) to the patient. During the expiratory phase, the exhaled air by the patient is directed through the intubation probe (11), the Y-piece (12) and the exhalation line (10) to be expelled into the ambient air. The aerosol is produced by the nebulizer in the inspiratory conduit (9) and is stored for the next inspiratory phase. Note that the branch line (13) may be integral with the Y-shaped part (12) without departing from the scope of the invention. According to a last variant embodiment of the nebulizing device according to the invention, with reference to FIG. 7, said device comprises in the same way as above, a reservoir (6) able to contain a liquid, said reservoir (6) comprising an upper opening (7) for pouring said liquid into the reservoir (6), a screen (2) comprising a plurality of microscopic holes and a piezoelectric device (1) in contact with the liquid contained in the reservoir (6). Said reservoir (6) comprises a frustoconical lower portion (6a) whose smallest base forms the lower opening which is closed by the sieve (2) maintained on the lower face of said reservoir (6) in line with said lower opening by a lower cylindrical part (3). The upper part (6b) of the reservoir is substantially cylindrical. The piezoelectric device (1) consists of a vertical piezoelectric cylinder extending inside the frustoconical lower part (6a) of the reservoir (6), at the sieve (2) and perpendicular to said sieve (2). ). The lower end of said piezoelectric cylinder (1) extends at a maximum distance of 2 mm from said screen (2) and the axis of the piezoelectric cylinder (1) is substantially coaxial with the axis of revolution of the lower part. (6a) of the reservoir (6). The piezoelectric cylinder (1) is powered by an electrical signal by means of two pins (4) and (5) which extend above the lower part (6a) of the tank (6), along the side wall of the cylindrical upper portion (6b) of said reservoir (6).

This variant of execution differs from those previously described in that it comprises a patient interface (14). The lower cylindrical part (3) is integral with the upper wall of the interface (14) which consists of a container (15) comprising a bottom wall (16), at least one side wall (17), an upper wall (18), and a mouthpiece (19), said lower cylindrical piece (3) opening into the container (15) whose upper wall is provided with a vent (20). Note that the mouthpiece (19) may be substituted by a nosepiece or a face mask without departing from the scope of the invention. This alternative embodiment allows the oral or naso-oral administration of the aerosol. Thus the generation of the aerosol is performed from top to bottom by the sieve (2) and the aerosol is produced in the interface (14). During the inspiratory phase, the air inhaled by the patient passes through the vent (20) and transports the aerosol produced through the mouthpiece buccal (19) to the patient. During the expiratory phase, the exhaled air by the patient is expelled through the same vent (20) and the aerosol produced is transported out through vent (20). Finally, it is obvious that the examples that have just been given are only particular illustrations in no way limiting as to the fields of application of the invention.

Claims

-1- Nebulizing device comprising at least one reservoir (6) adapted to contain a liquid, said reservoir (6) having an opening (O) on its outer surface for pouring said liquid into the reservoir (6), a fixed screen (2) comprising a plurality of microscopic holes and one face (2a), in contact with the same liquid contained in the reservoir, is disposed facing a piezoelectric device (1) which is in contact with the same liquid contained in the reservoir (6) so that the vibrations of the piezoelectric device (1) are transmitted to the liquid forcing its passage through the holes of the sieve (2) to generate an aerosol, from a face called transmission (2b) of the sieve characterized in that the opening (O) of the reservoir (6) for its filling in an operating position of said device, is located above the face (2a) of the sieve arranged, so horizontal in the operating position nt, and facing the piezoelectric device (1), in order to produce, in said operating position, an aerosol along an axis of the order of 30 degrees relative to the vertical, from top to bottom.

-2- Device according to claim 1, characterized in that the reservoir (6) comprises a frustoconical lower portion (6a) whose smallest base forms a lower opening which is closed by the sieve (2) maintained on the underside said reservoir (6) at the right of said lower opening by a lower cylindrical part (3).

-3- Device according to claim 1, characterized in that the piezoelectric device (1) consists of a vertical piezoelectric cylinder (1) extending inside the frustoconical lower part (6a) of the reservoir ( 6), at the sieve (2), perpendicular to said screen (2) and at a maximum distance of 2 mm from the latter.

-4- Device according to claim 1, characterized in that the holes of the sieve (2) have a diameter between 1 and 10 μιη.

-5- Device according to claim 4, characterized in that the screen (2) comprises between 100 and 10000 holes. -6- Device according to any one of claims 1 to 3, characterized in that the reservoir (6) has a form of revolution having a cylindrical upper portion (6b) having a central cylindrical recess (6c) and the frustoconical lower portion (6a).

-7- Device according to claim 6, characterized in that the piezoelectric cylinder

(I) extends coaxially with the axis of revolution of the reservoir (6). -8- Device according to any one of claims 1 to 7, characterized in that it comprises a control circuit of the piezoelectric device adapted to vibrate said piezoelectric cylinder (1) at a frequency between 10 and 500 KHz.

-9- Device according to any one of claims 1 to 8, characterized in that the lower cylindrical part (3) is integral with the upper wall of an interface (14) consisting of a container (15) comprising a wall base (16), at least one side wall (17), an upper wall (18), and a mouthpiece (19) or a face mask, said lower cylindrical piece (3) opening into the container (15) whose wall upper (18) is provided with a vent (20).

-10- Device according to claim 9, characterized in that the tip (19) consists of a mouthpiece or nasal.

-11- Device according to any one of claims 1 to 8, characterized in that it comprises a respirator (8) comprising an inspiration pipe (9) and an exhalation pipe (10) connected to a probe d flexible intubation (11) by a Y-shaped piece (12), said inspiration line (9) and / or the end of the Y-shaped piece

(II) comprises a bypass line (13) adapted to receive the lower cylindrical piece (3) so that, during the inspiratory phases of the aerosol is projected in the inspiration pipe (9) and / or the piece of Y shape (12).