WO2022140292A1

WO2022140292A1 - Aerosol generating device and method

Info

Publication number: WO2022140292A1
Application number: PCT/US2021/064426
Authority: WO
Inventors: Dalton Vaughn SIGNOR; Chrys CAMACHO
Original assignee: Breatheasy Co.
Priority date: 2020-12-21
Filing date: 2021-12-20
Publication date: 2022-06-30

Abstract

Exemplary embodiments are directed to an aerosol generating device including a mouthpiece and a base assembly configured to be removably coupled to the mouthpiece. The mouthpiece includes a reservoir capable of receiving a liquid solution, and an opening extending through the mouthpiece. The base assembly includes an aerosolization chamber configured to receive the liquid solution from the reservoir of the mouthpiece, and an aerosolization element disposed in the aerosolization chamber, the aerosolization element capable of aerosolizing the liquid solution for inhalation through the opening of the mouthpiece.

Description

AEROSOL GENERATING DEVICE AND METHOD

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] The present application claims the benefit of priority to U.S. Provisional Application No. 63/128,296, filed December 21, 2020, and U.S. Provisional Application No. 63/254,561, filed October 12, 2021, each of which is hereby incorporated by reference in its entirety.

TECHNICAL FIELD

[0002] The present disclosure relates generally to an aerosol generating device and associated methods. More specifically, the present disclosure relates to an aerosol generating device capable of effectively operating at any orientation.

BACKGROUND

[0003] Nebulizers are generally used in the industry for delivery of aerosol medications, consumer dietary supplements, and consumer products. Nebulizers are capable of turning an aqueous solution into an inhalable mist. In general, such traditional nebulizers are either jet nebulizers, ultrasonic nebulizers, or vibrating mesh nebulizers. Typically, jet nebulizers are not portable and necessitate an external power source for use. Traditional nebulizers generally necessitate that the device be oriented substantially upright due to reliance on gravity for continuous liquid supply. If the device is not used in the proper orientation, the aerosolization process may be disrupted, resulting in the improper or ineffective delivery of the aerosol medicament. This can lead to a high probability of user error and can provide a significant barrier to using the device in an on-the-go manner.

SUMMARY

[0004] In accordance with embodiments of the present disclosure, an exemplary aerosol generating device is provided. The aerosol generating device can include a mouthpiece including a reservoir capable of receiving a liquid solution, and an opening extending through the mouthpiece. The aerosol generating device can include a base assembly configured to be removably coupled to the mouthpiece. The base assembly can include an aerosolization chamber configured to receive the liquid solution from the reservoir of the mouthpiece. The base assembly can include an aerosolization element disposed in the aerosolization chamber. The aerosolization element is capable of aerosolizing the liquid solution for inhalation through the opening of the mouthpiece.

[0005] The opening of the mouthpiece, the aerosolization chamber, and the aerosolization element can be aligned (or substantially aligned) along a central longitudinal axis of the aerosol generating device. In some embodiments, the opening of the mouthpiece can include a first large diameter section at a top surface of the mouthpiece, a second large diameter section at a bottom surface of the mouthpiece, and a narrow diameter section connecting the first and second large diameter sections. In some embodiments, the first and second large diameter sections can both include tapered walls towards the narrow diameter section. In some embodiments, the opening can be a cylindrical shape with the first and second large diameter sections having equal diameters.

[0006] The reservoir of the mouthpiece can circumferentially surround the opening of the mouthpiece. The mouthpiece can include at least one drainage channel extending from the reservoir. The mouthpiece can include a breakable membrane covering an opening associated with the at least one drainage channel to prevent flow of the liquid solution from the mouthpiece.

[0007] The aerosol generating device is capable of being used in an orientation agnostic manner, with the aerosolization element capable of aerosolizing the liquid solution in any orientation of the aerosol generating device. The base assembly can include a printed circuit board and a power source for actuation of the aerosolization element. The base assembly can include an actuator configured to receive a force for initiation of aerosolization of the liquid solution.

[0008] The base assembly can include at least one drainage passage fluidly connected to a solution reservoir of the aerosolization chamber. The at least one drainage passage can include a feature configured to at least partially break a breakable membrane of the mouthpiece to release flow of the liquid solution from the mouthpiece, through the at least one drainage passage, and into the solution reservoir of the aerosolization chamber.

[0009] In some embodiments, the device can include an absorbable element disposed within the solution reservoir. The absorbable element is configured to absorb at least some of the liquid solution within the solution reservoir. In some embodiments, the absorbable element can be a medical grade sponge. The absorbable element is oriented in a substantially vertical orientation to abut a bottom surface of the solution reservoir at one end and abut a bottom surface of the aerosolization element at an opposing end. In some embodiments, the base assembly can include a stepped opening dimensioned to support the aerosolization element.

[0010] In accordance with embodiments of the present disclosure, an exemplary method of generating aerosol is provided. The method includes removably coupling a mouthpiece of an aerosol generating device to a base assembly of the aerosol generating device. The mouthpiece includes a reservoir capable of receiving a liquid solution, and an opening extending through the mouthpiece. The base assembly includes an aerosolization chamber, and an aerosolization element disposed in the aerosolization chamber. The method includes draining the liquid solution from the reservoir of the mouthpiece into the aerosolization chamber of the base assembly. The method includes activating the aerosolization element to aerosolize the liquid solution for inhalation through the opening of the mouthpiece.

[0011] The mouthpiece can include at least one drainage channel extending from the reservoir with a breakable membrane covering an opening associated with the at least one drainage channel. The base assembly can include at least one drainage passage fluidly connected to a solution reservoir of the aerosolization chamber. The method can include removably coupling of the mouthpiece with the base assembly to at least partially break the breakable membrane of the mouthpiece with a feature of the at least one drainage passage of the base assembly to allow for draining of the liquid solution from the reservoir of the mouthpiece into the aerosolization chamber of the base assembly.

[0012] In accordance with embodiments of the present disclosure, an exemplary aerosol generating system is provided. The system includes an aerosol generating device including a mouthpiece and a base assembly configured to be removably coupled to the mouthpiece. The mouthpiece includes a reservoir capable of receiving a liquid solution, and an opening extending through the mouthpiece. The base assembly includes an aerosolization chamber configured to receive the liquid solution from the reservoir of the mouthpiece, and an aerosolization element disposed in the aerosolization chamber. The aerosolization element is capable of aerosolizing the liquid solution for inhalation through the opening of the mouthpiece. The system includes an external device including a graphical user interface. The external device is capable of receiving and processing data associated with implementation of the aerosol generating device. [0013] In accordance with embodiments of the present disclosure, an exemplary aerosol generating device is provided. The device includes a mouthpiece including an opening extending through the mouthpiece. The device includes a base assembly coupled to the mouthpiece. The base assembly includes an aerosolization chamber configured to receive a liquid solution. The base assembly includes an aerosolization element. The aerosolization element is capable of aerosolizing the liquid solution for inhalation through the opening of the mouthpiece. The device includes an absorbable element disposed within the aerosolization chamber and positioned in constant fluid communication with the aerosolization element. The absorbable element is capable of providing constant supply of the liquid solution in the aerosolization chamber to the aerosolization element.

[0014] In accordance with embodiments of the present disclosure, an exemplary method of generating aerosol is provided. The method includes removably coupling a mouthpiece of an aerosol generating device to a base assembly of the aerosol generating device. The mouthpiece includes an opening extending through the mouthpiece. The base assembly includes an aerosolization chamber configured to receive a liquid solution, an aerosolization element, and an absorbable element disposed within the aerosolization chamber and positioned in constant fluid communication with the aerosolization element. The method includes providing a constant supply of the liquid solution from the aerosolization chamber to the aerosolization element with the absorbable element. The method includes activating the aerosolization element to aerosolize the liquid solution for inhalation through the opening of the mouthpiece.

[0015] In accordance with embodiments of the present disclosure, an exemplary aerosol generating system is provided. The system includes an aerosol generating device including a mouthpiece and a base assembly coupled to the mouthpiece. The mouthpiece includes an opening extending through the mouthpiece. The base assembly includes an aerosolization chamber configured to receive a liquid solution, and an aerosolization element. The aerosolization element is capable of aerosolizing the liquid solution for inhalation through the opening of the mouthpiece. The base assembly includes an absorbable element disposed within the aerosolization chamber and positioned in constant fluid communication with the aerosolization element. The absorbable element is capable of providing constant supply of the liquid solution in the aerosolization chamber to the aerosolization element. The system includes an external device including a graphical user interface. The external device is capable of receiving and processing data associated with implementation of the aerosol generating device.

[0016] In accordance with embodiments of the present disclosure, an exemplary portable aerosol generating and delivery system is provided. The system includes a body that has a charging end and an open end, including the power supply, charging station, and circuitry. The system includes an aerosolization chamber that has a bottom and a surface, including a reservoir, a draining system, at least one draining point, and a piezoelectric element. In some embodiments, the reservoir can contain or house an absorbent material. The system includes a mouthpiece capsule that has a bottom and an inhalation point, including a hollow section that allows for air flow, a reservoir that holds a liquid solution, and at least one receiving point. The bottom of the aerosolization chamber is connected to the open end of the body, and the bottom of the mouthpiece capsule is connected to the surface of the aerosolization chamber, characterized in that, the mouthpiece capsule is detachable from the aerosolization chamber.

[0017] In some embodiments, one side can be characterized by a concave fillet that is intended to receive a person’s thumb. The concave section of the body can include a button, whereupon a force applied to said button actuates the piezoelectric element of the aerosolization chamber. In some embodiments, the button may be a force resistive sensor. In some embodiments, the piezoelectric element can be actuated by a pressure sensor that responds to inspiration by a person. In some embodiments, the aerosolization chamber includes a piezoelectric element that is positioned horizontally above the reservoir, such that the bottom of said piezoelectric element is contiguous with the open space of the reservoir. In some embodiments, the piezoelectric element is positioned in a constant fluid communication with a section of the absorbent material to ensure continuous supply of the fluid to the piezoelectric element via the absorbent material. The resultant aerosol produced by the actuation of said piezoelectric element is oriented in-line with the longitudinal axis of the portable aerosol generating and delivery system.

[0018] The piezoelectric element can be housed within a piezo element casing. The piezo element casing can include two layers of a vibration absorbent material, two layers of hard plastic, and the piezoelectric element. The piezoelectric element is located horizontally between the two layers of vibration absorbent material, and this configuration is placed between the two layers of hard plastic. When assembled, the two layers of hard plastic snap together by means of a lip, securing the piezo element casing such that said component parts may not separate.

[0019] The piezoelectric element can include a piezoceramic material and a mesh material. The mesh material is characterized by multiple laser drilled and/or micromachined apertures. The number, size, and configuration of the apertures on said mesh material may be altered with the purpose of achieving a specific aerosol particle size distribution. The piezoelectric element can be a silicone micro-electro-mechanical system. The reservoir of the aerosolization chamber includes a body of absorbent material, characterized in that, at least one point of said absorbent material is flush against the bottom of the piezoelectric element. The absorbent material can be a sponge or sponge-like material with antimicrobial properties, characterized in that, it is able to absorb and retain a liquid solution.

[0020] The draining system transports liquid from the draining points of the aerosolization chamber to the reservoir. In some embodiments, the draining system can include a one-way valve that restricts the direction of liquid flow, characterized in that, liquid may flow from the mouthpiece capsule into the draining system, but may not flow from the draining system into the mouthpiece capsule. The aerosolization chamber includes at least one draining point, characterized in that, said draining point is an extruded piece of material that is capable of penetrating the corresponding receiving point on the mouthpiece capsule.

[0021] The mouthpiece capsule is characterized in that, the bottom of said mouthpiece capsules connects to the surface of the aerosolization chamber. The liquid from the mouthpiece capsule flows into the draining points of the aerosolization chamber, and the inhalation point of the mouthpiece capsule is intended to be inserted into a person’s mouth during inspiration. An aerosol produced by the piezoelectric element of the aerosolization chamber is expelled into the hollow section of the mouthpiece capsule, and is then inhaled by a person. In some embodiments, a mobile application can be connected to the portable aerosol generating and delivery system. The application utilizes a range of input features to predict the optimal dose level for an individual, and then monitors and adjusts said optimal dose level over time in response to changing input features. This may be accomplished by means of machine learning, or non-machine learning based algorithms.

[0022] Other features and advantages will become apparent from the following detailed description considered in conjunction with the accompanying drawings. It is to be understood, however, that the drawings are designed as an illustration only and not as a definition of the limits of the invention.

BRIEF DESCRIPTION OF THE DRAWINGS

[0023] To assist those of skill in the art in making and using the disclosed aerosol generating device and method, reference is made to the accompanying figures, wherein:

[0024] FIG. 1 is a front, perspective view of an exemplary aerosol generating device in accordance with the present disclosure;

[0025] FIG. 2 is a front view of an exemplary aerosol generating device of FIG. 1;

[0026] FIG. 3 is a side view of an exemplary aerosol generating device of FIG. 1 ;

[0027] FIG. 4 is a front view of an exemplary aerosol generating device of FIG. 1;

[0028] FIG. 5 is a cross-sectional view of an exemplary aerosol generating device of FIG. 4;

[0029] FIG. 6 is a front, transparent view of an exemplary aerosol generating device of FIG. 1;

[0030] FIG. 7 is a front view of a base housing of an exemplary aerosol generating device of FIG. 1;

[0031] FIG. 8 is a front, perspective view of a body of an exemplary aerosol generating device of FIG. 1 ;

[0032] FIG. 9 is a top view of a body of an exemplary aerosol generating device of FIG. 1;

[0033] FIG. 10 is a rear view of a body of an exemplary aerosol generating device of FIG. 1;

[0034] FIG. 11 is a front view of a body of an exemplary aerosol generating device of FIG. 1;

[0035] FIG. 12 is a front, transparent view of a body of an exemplary aerosol generating device of FIG. 1 ; [0036] FIG. 13 is a front view of a body of an exemplary aerosol generating device of FIG. 1;

[0037] FIG. 14 is a side view of a body of an exemplary aerosol generating device of FIG. 1;

[0038] FIG. 15 is a side, transparent view of a body of an exemplary aerosol generating device of FIG. 1 ;

[0039] FIG. 16 is a front, transparent view of body of an exemplary aerosol generating device of FIG. 1 ;

[0040] FIG. 17 is a side, transparent view of a body of an exemplary aerosol generating device of FIG. 1 ;

[0041] FIG. 18 is a side, cross-sectional view of a body of an exemplary aerosol generating device of FIG. 1 ;

[0042] FIG. 19 is a front view of a printed circuit board of an exemplary aerosol generating device of FIG. 1 ;

[0043] FIG. 20 is a side view of a printed circuit board of an exemplary aerosol generating device of FIG. 1 ;

[0044] FIG. 21 is a rear view of a printed circuit board of an exemplary aerosol generating device of FIG. 1 ;

[0045] FIG. 22 is a perspective view of a base housing of an exemplary aerosol generating device of FIG. 1 ;

[0046] FIG. 23 is a top view of a base housing of an exemplary aerosol generating device of FIG. 1;

[0047] FIG. 24 is a bottom view of a base housing of an exemplary aerosol generating device of FIG. 1 ;

[0048] FIG. 25 is a front, transparent view of a base housing of an exemplary aerosol generating device of FIG. 1 ; [0049] FIG. 26 is a side view of a base housing of an exemplary aerosol generating device of FIG. 1 ;

[0050] FIG. 27 is a rear view of a base housing of an exemplary aerosol generating device of FIG. 1 ;

[0051] FIG. 28 is a side, transparent view of a base housing of an exemplary aerosol generating device of FIG. 1 ;

[0052] FIG. 29 is a front view of a mouthpiece of an exemplary aerosol generating device of FIG. 1;

[0053] FIG. 30 is a front, transparent view of a mouthpiece of an exemplary aerosol generating device of FIG. 1 ;

[0054] FIG. 31 is a front, cross-sectional view of a mouthpiece of an exemplary aerosol generating device of FIG. 1 ;

[0055] FIG. 32 is a top, transparent view of a mouthpiece of an exemplary aerosol generating device of FIG. 1 ;

[0056] FIG. 33 is a top view of a mouthpiece of an exemplary aerosol generating device of FIG. 1;

[0057] FIG. 34 is a bottom view of a mouthpiece of an exemplary aerosol generating device of FIG. 1 ;

[0058] FIG. 35 is a side, transparent view of an actuator assembly of an exemplary aerosol generating device of FIG. 1 ;

[0059] FIG. 36 is a perspective view of an actuator of an exemplary aerosol generating device of FIG. 1 ;

[0060] FIG. 37 is a front, transparent view of an actuator of an exemplary aerosol generating device of FIG. 1 ;

[0061] FIG. 38 is a top view of an actuator of an exemplary aerosol generating device of FIG. 1; [0062] FIG. 39 is a side view of an actuator of an exemplary aerosol generating device of FIG. 1;

[0063] FIG. 40 is a front view of an actuator of an exemplary aerosol generating device of FIG. 1;

[0064] FIG. 41 is a side view of an actuator of an exemplary aerosol generating device of FIG. 1;

[0065] FIG. 42 is a top view of an aerosolizing element of an exemplary aerosol generating device of FIG. 1 ;

[0066] FIG. 43 is a block diagram of an exemplary computing device for implementing an exemplary aerosol generating device in accordance with the present disclosure; and

[0067] FIG. 44 is a block diagram of an exemplary aerosol generating device/system environment in accordance with the present disclosure.

DETAILED DESCRIPTION

[0068] In addition, it should be understood that the invention is not limited to embodiments having specific dimensions. Thus, any dimensions provided herein are merely for an exemplary purpose and are not intended to limit the invention to embodiments having particular dimensions.

[0069] The present disclosure generally relates to devices, methods, and systems for producing/generating an aerosol that is intended to be inhaled by a person. Such devices can be used for the administration of medicine, dietary supplements, novel formulations, or the like, across a wide range of medical and consumer indications. In some embodiments, the exemplary devices can be used for the delivery of aerosol medications to treat diseases, including, but not limited to, asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, diabetes, smoking cessation, or the like, as well as for the delivery of consumer dietary supplements and other consumer products that include, but are not limited to, nicotine, cannabis, and cannabidiol (CBD). The exemplary aerosol generating device includes internal components that allow for effective and continuous operation at different orientations of the device (including non- upright orientations). The device therefore ensures effective aerosol delivery by minimizing the possibility for user error, while maximizing portability and ease of use. Such devices lead to a more effective and efficient treatment.

[0070] In some embodiments, the device can be used as an aerosol delivery system intended to aid in the process of smoking cessation. Traditional cessation offerings primarily include gums, lozenges, transdermal patches, and prescription drugs, have been found to have low efficacy rates. The most common nicotine replacement therapy (NRT) products are generally gums, lozenges, and patches. These are products that are FDA approved for smoking cessation, and they deliver a specific dose of nicotine via an alternate delivery route (orally or transdermal) in order to help reduce the effect of nicotine withdrawal symptoms. These products generally have an efficacy rate of 10%-15% in the short term (about 3 months), reduced to as low as 5% at about 12 months from the beginning of treatment. With a long-term failure rate of 95%, millions of smokers who attempt to quit are failing and relapsing repeatedly. As an example, efficacy rates for the prescription drug CHANTIX® are higher than NRT products (approximately 20%), however such prescription drug is less widely used by smokers due to the high price of the medication and the severity of its associated side effects. The exemplary device can be used to assist with smoking cessation in an effective manner, and therefore serves the public health interest.

[0071] The present disclosure relates to a portable heatless aerosol generating and delivery system/device designed to deliver an aerosolized medication, dietary supplement, and/or other formulations to a person across a range of indications and disease states, which include but are not limited to asthma, COPD, cystic fibrosis, diabetes, smoking cessation, the delivery of medical cannabis, medical psychedelics, and non-medical consumer products. The portable heatless aerosol generating and delivery system can generally include three components: the body, the aerosolization chamber, and the mouthpiece capsule. The body includes, but is not limited to, the power source, the charging mechanism, and the associated circuitry. The aerosolization chamber includes a piezoelectric material, a reservoir located directly beneath said piezoelectric material. In some embodiments, the reservoir can be a hollow reservoir. In some embodiments, the aerosolization chamber can include a body of absorbent material. The aerosolization chamber can include tubes that span from the reservoir to the surface of the aerosolization chamber. The mouthpiece capsule can include a hollow section that allows for air flow, and an enclosed liquid housing. The mouthpiece capsule attaches to the surface of the aerosolization chamber to allow liquid to flow between the two components of the device. In some embodiments, the device can utilize one of the following piezoelectric ceramic materials: barium titanate, potassium niobate, sodium tungstate, or lead zirconate titanate. In some embodiments, the device can utilize silicone based micro-electro-machined systems (MEMS) technology. The device can be used solely to deliver a medical or non-medical grade solution to a person. In some embodiments, the device can be utilized in conjunction with a remote monitoring application (e.g., a user interface on a computing or mobile device) that is intended to maximize the efficacy of the delivery of a particular solution to the end user, whom may either be a patient or a consumer.

[0072] The device is a portable nebulizer that is capable of turning a liquid solution into an aerosol that may be inhaled by a person. The device utilizes, e.g., a piezoceramic material, a silicone MEMS (micro-electro-mechanical systems) technology, piezoelectric micromachined ultrasonic transducer (PMUT) technology, combinations thereof, or the like. The device is capable of generating and delivering an aerosol without the use of heat. The device includes three sections. The body of the device includes a molded housing that includes the printed circuit board (PCB), a lithium-ion battery, an LED display, a USB charging port, an inductor, and, in some embodiments, a force resistive button. The device can be actuated upon the button receiving a force. In some embodiments, a pressure sensor that is actuated upon inspiration by a person can automatically initiate actuation of the device. Said housing in the body of the device may include a low power consumption Bluetooth chip, this chip enabling a one-way communication from the aerosol generating system to a connected mobile application on a mobile device. In such instances, the aerosol generating system sends data regarding, but not limited to, frequency of use, time of use, and total consumption. This information is collected, stored, analyzed, and represented in multiple formats by the mobile application software using a graphical user interface (GUI). In some embodiments, the device may be capable of a two-way data flow, in which data collected in the mobile application is used to determine and regulate the aerosol output of the device. The body of the device can be separated from the aerosolization chamber by a plate which can be, e.g., a plastic material, a silicone material, a mesh material, or the like. The plate can be secured with an adhesive such that it can prevent an aqueous solution from penetrating into the body of the device from the aerosolization chamber.

[0073] The aerosolization chamber includes a draining system, which, in some embodiments, can be a funnel, and in some embodiments, can be a network of tubes connecting to a small reservoir and a centrally located piezo transducer element. The transducer element is, in some embodiments, a piezoceramic mesh structure, and in some embodiments a MEMS technology/assembly. The bottom cross section of the transducer element can be positioned directly above a reservoir in such a way that the liquid in the reservoir is flush (or substantially flush) against the bottom cross sectional area defined by the piezo transducer element when the reservoir is full. In some embodiments, an absorbent material can be disposed within the reservoir and is flush (or substantially flush) to the bottom side of the piezo transducer element. The absorbent material can be, but is not limited to, a sponge, sponge-like material, mesh material, or wick material. Actuation of the piezo transducer element can, in some embodiments, occur when a force is applied to a touch resistive button. In some embodiments, actuation of the piezo transducer element can occur when a pressure sensor is engaged by the force of inhalation from a person (e.g., automatically actuated upon detection by the pressure sensor of inhalation by the user). Upon actuation, the piezo transducer element is excited into out-of -plane vibration in such a way as to push liquid through the apertures in the mesh cross section element and eject them out of the other side of the element as a fine mist or aerosol. This aerosol then travels through the hollow section in the mouthpiece capsule and is inhaled by the user.

[0074] The draining system serves as a system to guide liquid from the mouthpiece capsule and into a reservoir directly below the piezo transducer element such that, when actuated, the element will generate an aerosol which is intended to be inhaled by the user. The reservoir positioned beneath the atomizer can have a volume of about, e.g., 0.1-1 mL inclusive, 0.1-0.9 mL inclusive, 0.1-0.8 mL inclusive, 0.1-0.7 mL inclusive, 0.1-0.6 mL inclusive, 0.1-0.5 mL inclusive, 0.1-0.4 mL inclusive, 0.1-0.3 mL inclusive, 0.1-0.2 mL inclusive, 0.2-1 mL inclusive, 0.3-1 mL inclusive, 0.4-1 mL inclusive, 0.5-1 mL inclusive, 0.6-1 mL inclusive, 0.7-1 mL inclusive, 0.8-1 mL inclusive, 0.9-1 mL inclusive, 0.1 mL, 0.2 mL, 0.3 mL, 0.4 mL, 0.5 mL, 0.6 mL, 0.7 mL, 0.8 mL, 0.9 mL, 1 mL, or the like. As the liquid from the mouthpiece capsule drains into the reservoir, the force of gravity directs the liquid through the drainage system and into the reservoir. Therefore, as long as the amount of liquid in the mouthpiece capsule and/or the drainage system is equal to or greater than the volume of the reservoir, the reservoir will remain full of liquid such that it can be selectively aerosolized uniformly and effectively. Once the amount of liquid in the mouthpiece capsule and/or the drainage system has a value less than the volume of the reservoir, the now empty (or substantially empty) mouthpiece capsule can be removed by the user and replaced with a new mouthpiece capsule for continued use. The drainage system, while using gravity as its guiding force, renders the aerosol delivery device at least partially orientation agnostic. In particular, the device can be used by a person in a 180-degree range of motion, and it will function as intended (e.g., providing continuous and uniform aerosolized spray, resulting in accurate use). In some embodiments, the reservoir in the aerosolization chamber can include an absorbent material that is positioned flush against the bottom cross section of the piezo transducer element, such that as liquid drains from the mouthpiece capsule into the reservoir, it is at least partially stored within the absorbent material. The absorbent material is intended to absorb liquid at a controlled, predetermined rate such that the proper amount of liquid is provided to the piezoelectric transducer element. For example, during use of the device, the absorbent material can continuously absorb the liquid from the reservoir to ensure the proper amount of liquid is continuously provided to the piezoelectric transducer element without “flooding” the piezoelectric transducer element. As the piezo transducer element oscillates, each vibration brings the piezo transducer element into contact with the absorbent material, drawing liquid from the absorbent material (and the reservoir) through the apertures in the mesh and producing an aerosol. The aerosolization chamber is substantially the same as previously described, but also includes the absorbent material within the reservoir. The presence of the absorbent material, and the tendency of liquid towards capillary action, allows the device to perform in an entirely orientation agnostic manner (e.g., 360 degrees of orientation). As the piezo transducer element contacts the mesh and releases liquid droplets, liquid will move from the areas of high concentration to the area of low concentration directly beneath the piezo element, providing a continuous supply of liquid to be aerosolized without the need for gravity to supply it. Thus, the absorbent material continuously provides liquid to the piezo transducer element (while sufficient liquid is in the reservoir). Rather than relying on gravity to provide a source of liquid to be in contact with the piezo transducer element, the absorbent material provides a continuous source of liquid. This allows the device to be positioned and operated effectively in any orientation (even upside down), with the absorbent material continuing to provide liquid for aerosolization.

[0075] The liquid filled mouthpiece capsule includes a hollow section that allows for air flow, and an enclosed section that holds an aqueous solution. The cavity contains at least one receiving point that serves as the site for liquid to move from the mouthpiece capsule and into the aerosolization chamber. The bottom side of the mouthpiece capsule attaches to a top surface of the aerosolization chamber. Such connection can be accomplished by, e.g., a lip on the mouthpiece capsule, draining points that insert from the aerosolization chamber into the mouthpiece capsule, a combination of both, or the like. The bottom of the mouthpiece capsule includes at least one receiving point that is covered with a thin film. The film can be, e.g., a silicone material, a foil material, a thin plastic material, a thin mesh material, or the like. The film creates a breakable membrane upon connection of the mouthpiece capsule with the aerosolization chamber.

[0076] In particular, the mouthpiece capsule is attached to the aerosolization chamber in such a manner that the receiving points referenced above align with the draining points that are positioned on the surface of the aerosolization chamber. Alignment and connection of the mouthpiece capsule with the aerosolization chamber allows for the draining points to penetrate the receiving points, breaking through the thin firm/breakable membrane, and enables the liquid solution to flow from the mouthpiece capsule and into the aerosolization chamber. The draining points can be, e.g., a funnel configuration, cylindrical hollow tubes, or the like. The cylindrical hollow tubes can define an outer diameter of about, e.g., 0.1-3 mm inclusive, 0.1-2.5 mm inclusive, 0.1-2 mm inclusive, 0.1-1.5 mm inclusive, 0.1-1 mm inclusive, 0.1-0.5 mm inclusive, 0.5-3 mm inclusive, 1-3 mm inclusive, 1.5-3 mm inclusive, 2-3 mm inclusive, 2.5-3 mm inclusive, 0.1 mm, 0.5 mm, 1 mm, 1.5 mm, 2 mm, 2.5 mm, 3.0 mm, or the like. The draining points can be fabricated from, e.g., a plastic material, a silicone material, a mesh material, a metal material, combinations thereof, or the like. The receiving tubes have a structure and composition rigid enough to penetrate the thin film of the drainage points and maintain their form and functionality. A silicone gasket and/or ring can be attached to the end of the receiving point, or around the draining point, or can be dually attached with one silicone gasket on the end of the receiving point and a second silicone gasket ring attached around the draining point. The device can include a one-way valve positioned on the drainage point and/or on the receiving tube, such that once the aqueous solution drains from the mouthpiece capsule into the aerosolization chamber, it cannot flow back into the mouthpiece capsule regardless of the orientation of the device.

[0077] The hollow section in the mouthpiece capsule connects both ends of the mouthpiece, allowing for generated aerosol to flow through the mouthpiece and into the user's mouth during inspiration. The top end of the mouthpiece is intended to be placed into the user's mouth during inspiration. The mouthpiece has an ergonomic form factor and design that allows for it to easily fit between a person's lips, ensuring inspiration of the entire aerosolized supply. The bottom end of the hollow section, which is positioned towards the bottom end of the mouthpiece capsule that connects to the aerosolization chamber when attached to the delivery device, is positioned directly above the mesh cross section of the piezo transducer element. When actuated, the aerosol generated from the piezo transducer element will be ejected from the mesh material into the opening in the mouthpiece capsule, where it will travel into the user’s mouth and lungs during inspiration. The opening can have no obstructions in the path, or can include one or more guiding lines running down the longitudinal axis of the opening to guide the aerosol flow. In some embodiments, the opening and/or passage can include ligaments to obstruct the aerosol flow, with these obstructions purposefully placed to create an aerosol dynamic that ensures the proper disposition of particles into the targeted parts of the respiratory tract.

[0078] This device is intended to aerosolize a medical or non-medical grade liquid solution. The liquid solution can be, e.g., a medication, a dietary supplement, a novel formulation, or the like. The solution can include numerous active and/or inactive ingredients. The solution can be processed by, e.g., nanosizing and/or microencapsulating the particles. The aqueous solution can include a liposomal nano dispersion.

[0079] A mobile application (e.g., using a graphical user interface on a computing and/or mobile device) can be used in combination with the device. The mobile application can be connected to the aerosol generating system via a Bluetooth Low Energy (BLE) connection, or another connection that allows for data to be transmitted between the device and the mobile application. In some embodiments, such transmission can be a one-way communication in which data is sent from the aerosol generating system to the mobile application, and this data is collected, stored, analyzed, and represented in multiple formats by the mobile application software. In some embodiments, the connection can enable a two-way data flow in which data is sent from the device to the mobile application, and the mobile application collects, stores, analyzes, and uses said data to program the device for specific output functionality (e.g., the mobile application regulates use of the device, such as the dosing, aerosolization flow rate, and/or the number of times the device can be used based on collected/analyzed data). In some embodiments, the mobile application component can be used as a behavioral method for achieving smoking cessation outcomes, characterized by a Quit Progression Plan. Such progression plan can be parsed into two sections: the Quit Phase, and the Behavioral Phase.

[0080] In the Quit Phase, the purpose can be to aid a person in overcoming the physiological addiction to nicotine. The person uses the aerosol delivery system as frequently as needed to manage their nicotine withdrawal symptoms. This phase can last for a period of time, e.g., 5 to 30 days, inclusive. During the Quit Phase, the mobile application establishes a baseline usage based on collected data, where the baseline usage is an average of a person's daily use over the entirety of the Quit Phase time period. In the Behavioral Phase, the purpose can be to aid a person in overcoming their addiction to the physical act of smoking. This can be represented in the form of, e.g., oral fixation, inhaling a substance, holding a small object in one's hand, or the like. During the Behavioral Phase, the mobile application sets a cessation progression plan that is dependent on a plurality of inputs from the user. The inputs can include, e.g., the established baseline usage during the Quit Phase, the number of cigarettes or the equivalent amount of e-liquid normally consumed prior to cessation, a person’s smoking triggers (where a trigger is defined as a time, location, action, or other occurrence that causes one to have an increased desire to smoke), a person's aggressiveness in their desire to quit (where a person may desire to decrease their consumption at a rapid rate and this person is defined as being aggressive in their cessation plan), combinations thereof, or the like. These factors can be used to determine the length of the Behavioral Phase for a person, with the purpose of the Behavioral Phase being to decrease a person’s usage of the device disclosed herein from the baseline usage established during the Quit Phase to zero continued usage by the end of the cessation progression plan. The length of the cessation progression plan is dependent on the factors described above.

[0081] The two-phased approach described above is targeted at providing the most effective smoking cessation solution, with each phase addressing a distinct addiction. The Quit Phase (e.g., phase one) addresses the physiological addiction to nicotine, and during this phase a person will be experiencing affective withdrawal symptoms. The withdrawal symptoms can include, e.g.,, anxiety, irritability, depression, hostility, difficulty focusing, combinations thereof, or the like. The use of the aerosol generating system is intended to aid a person in managing and reducing such affective nicotine withdrawal symptoms. The Quit Phase can last for a duration of 5 to 30 days, during which the person is instructed to use the aerosol generating system throughout the day as much as is necessary to maintain cessation (wherein maintaining cessation can be defined as not consuming nicotine). At the end of the Quit Phase, the physiological addiction to nicotine will have been addressed. However, a person is still likely to be addicted to the act of smoking, which is addressed as a separate addiction and is resolved with the Behavioral Phase of the Quit Progression Plan. The focus of the Behavioral Phase is to reduce a person’s use of the device gradually, such that over a matter of months they reduce their use of the device to zero. Thus, by the end of this period of time, the person is no longer addicted to the physical act of smoking, characterized by no longer feeling the desire to smoke or inhale a substance from a cigarette or electronic device. The two-phased approach parses smoking cessation into two distinct addiction phases, the first addiction phase is the addiction to nicotine and the second addiction phase is the addiction to the act of smoking, and proposes a solution that independently addresses each addiction in such a way as to promote the effective resolution of each addiction phase. Ultimately, this leads to a complete cessation from the use of any cigarette or electronic nicotine delivery systems (ENDS). Both phases can, in some embodiments, utilize machine learning models incorporated into the mobile application to personalize dosage recommendations that are intended to maximize efficacy of the inhaled solution and/or minimize withdrawal symptoms experienced by the specific patient. [0082] FIGS. 1-44 are perspective, transparent, and cross-sectional views of the exemplary aerosol generating device 100 (hereinafter “device 100”), and components thereof. The figures illustrate the form factor and aesthetic configuration of the device 100. These two elements are specifically designed to allow for maximum portability of the device 100. Considering the range of use cases, the device 100 is suitable for operation in many environments, allowing the user to travel with the device 100 and use it throughout their day. The form factor and ergonomic design of the device 100 reflects this user requirement, rendering the device 100 suitable to be transported in one’s pocket and held in one’s hand with ease. As will be described in greater detail, the device 100 includes the body, and the removable mouthpiece capsule. During use, the top of the mouthpiece is intended to be inserted into the mouth of the user for inhalation of the aerosolized liquid. The mouthpiece (or at least a portion of the mouthpiece to be inserted into the mouth of the user) can be fabricated from, e.g., , a metal, plastic, or silicone material that is FDA approved for food contact.

[0083] The device 100 can include a force resistive button which, upon receiving a force from one’s finger, transfers a signal that actuates the atomizer to generate aerosol. In some embodiments, the force resistive button can be replaced or can be used in combination with a pressure sensor. Upon inhalation, the pressure sensor can transfer a signal that actuates the piezo transducer element to generate aerosol. Thus, the device 100 can automatically actuate upon inhalation by the user, with the aerosolized liquid being output almost instantaneously after initial inhalation. The force resistive button can be programmed such that a minimum force is required to actuate the device 100. In some embodiments, the minimum force on the button can be about, e.g., 0.18-0.25 pounds inclusive, 0.18-0.24 pounds inclusive, 0.18-0.23 pounds inclusive, 0.18-0.22 pounds inclusive, 0.18-0.21 pounds inclusive, 0.18-0.20 pounds inclusive, 0.18-0.19 pounds inclusive, 0.19-0.25 pounds inclusive, 0.20-0.25 pounds inclusive, 0.21-0.25 pounds inclusive, 22-25 pounds inclusive, 23-25 pounds inclusive, 24-25 pounds inclusive, 0.18 pounds, 0.19 pounds, 0.20 pounds, 0.21 pounds, 0.22 pounds, 0.23 pounds, 0.24 pounds, 0.25 pounds, or the like. Such minimum force requirement prevents the device 100 from being inadvertently actuated in an unwanted circumstance, for example, in a person’ s pocket. The size (diameter) and shape of the force resistive button can be altered in different embodiments of the device 100 to reflect an optimal ergonomic design. The device 100 can include visual indicators in the form of light-emitting diodes (LEDs) located underneath the force resistive button or at the front of the housing for the device 100. The LEDs can be used to visually indicate actuation of the device, battery level, liquid levels, combinations thereof, or the like. In some embodiments, the battery level function can be accessed by double tapping the force resistive button twice, and the LEDs can present a color that corresponds to a low, medium, or high battery level (e.g., red, yellow, or green).

[0084] The device 100 can include a housing with a fillet profile. The fillet can be used to create a more ergonomic design that allows the device 100 to easily fit into the hand of a user and be comfortably positioned during use. In general, all elements of the device 100 are aligned (or substantially aligned) along the longitudinal axis of the device 100, such that the aerosol is produced out of the top of the device 100. Traditional nebulizers generally have an aerosol flow that is perpendicular to the body of the device, due to the constraints of using gravity as the force that keeps the liquid positioned behind the aerosolizing element. The design of the exemplary device 100 allows for an in-line aerosol flow, which advantageously increases the portability of the device 100 and offers an orientation agnostic delivery of aerosol.

[0085] The body of the device 100 includes a housing for the electrical components, and the aerosolization chamber. The device 100 includes a draining system and the piezo transducer element. The housing includes the casing (which can include two molded parts that connect via a snap-fit), the battery, the printed circuit board (PCB), the inductor, LEDs, an actuator button, a universal serial bus (USB) port, and (optionally) a Bluetooth chip that provides connectivity to a mobile application. It should be understood that the exact position of these elements within the housing can be varied without departing from the present disclosure.

[0086] Directly above the housing is the aerosolization chamber. The aerosolization chamber is separated from the body by a plate that spans the inner cavity of the housing just above the inductor. The plate can be fabricated from, e.g., a metal, plastic, silicone, or mesh material, and serves the purpose of creating a watertight seal between the housing and the aerosolization system. The plate can be secured by an adhesive (e.g., silicone) that attaches the plate to the sides of the housing. This ensures that no liquid from the aerosolization system can leak into the housing and disrupt the electrical components.

[0087] The aerosolization chamber includes a piezo transducer element, prong holes, draining tubes (which can be empty cavities, tubes, a funnel reservoir, or the like). The piezo transducer element is centrally located in the aerosolization chamber. The piezo transducer element includes a piezoceramic material and a mesh material. In some embodiments, the element can include PMUT technology, e.g., a silicone MEMS technology, or the like. The a piezo transducer element can be of a variety of sizes (e.g., diameters) and shape options. In some embodiments, the element can be a disk with a diameter of about, e.g., 4-16 mm inclusive, 4-15 mm inclusive, 4-14 mm inclusive, 4-13 mm inclusive, 4-12 mm inclusive, 4- 11 mm inclusive, 4-10 mm inclusive, 4-9 mm inclusive, 4-8 mm inclusive, 4-7 mm inclusive,

4-6 mm inclusive, 4-5 mm inclusive, 5-15 mm inclusive, 6-15 mm inclusive, 7-15 mm inclusive, 8-15 mm inclusive, 9-15 mm inclusive, 10-15 mm inclusive, 11-15 mm inclusive, 12-15 mm inclusive, 13-15 mm inclusive, 14-15 mm inclusive, 4 mm, 5 mm, 6 mm, 7 mm, 8 mm, 9 mm, 10 mm, 11 mm, 12 mm, 13 mm, 14 mm, 15 mm, or the like. In some embodiments, the element can be, e.g., a circular, square, or rectangular shape. Liquid is pushed through the micro-sized apertures in a mesh material to generate particles of varying size, targeting a particle size in the respirable range of about, e.g., 1-15 microns inclusive, 1-

14 microns inclusive, 1-13 microns inclusive, 1-12 microns inclusive, 1-11 microns inclusive, 1-10 microns inclusive, 1-9 microns inclusive, 1-8 microns inclusive, 1-7 microns inclusive, 1-6 microns inclusive, 1-5 microns inclusive, 1-4 microns inclusive, 1-3 microns inclusive, 1- 2 microns inclusive, 2-15 microns inclusive, 3-15 microns inclusive, 4-15 microns inclusive,

5-15 microns inclusive, 6-15 microns inclusive, 7-15 microns inclusive, 8-15 microns inclusive, 9-15 microns inclusive, 10-15 microns inclusive, 11-15 microns inclusive, 12-15 microns inclusive, 13-15 microns inclusive, 14-15 microns inclusive, 3-10 microns inclusive, 5-10 microns inclusive, 1 micron, 2 microns, 3 microns, 4 microns, 5 microns, 6 microns, 7 microns, 8 microns, 9 microns, 10 microns, 11 microns, 12 microns, 13 microns, 14 microns,

15 microns, or the like. It should be understood that the apertures in the mesh material can be varied as needed based on the end user application, thereby adjusting the particle size beyond the noted range.

[0088] The configuration, size, and number of apertures in the mesh material can be altered to adjust the particle size and/or aerosol flow. The mesh cross section can include between about, e.g., 200-20,000 inclusive, 200-15,000 inclusive, 200-10,000 inclusive, 200- 5,000 inclusive, 200-1,000 inclusive, 200-500 inclusive, 500-20,000 inclusive, 1,000-20,000 inclusive, 5,000-20,000 inclusive, 10,000-20,000 inclusive, 15,000-20,000 inclusive, 200, 500, 1,000, 5,000, 10,000, 15,000, 20,000, or the like, tapered holes. The size (e.g., diameter) of the holes can be about, e.g., 1-100 microns inclusive, 1-80 microns inclusive, 1-60 microns inclusive, 1-40 microns inclusive, 1-20 microns inclusive, 1-10 microns inclusive, 10-100 microns inclusive, 20-100 microns inclusive, 40-100 microns inclusive, 60-100 microns inclusive, 80-100 microns inclusive, 10 microns, 20 microns, 40 microns, 60 microns, 80 microns, 100 microns, or the like. These tapered holes can be arranged in a variety of orientations, with specific orientations chosen to target different parts of the respiratory tract. The scope of this disclosure includes many varieties of size, number, and configuration of the tapered holes, as well as combinations thereof, whereupon a combination of a certain tapered hole size and configuration can, for example, be used to create small particles that will be directed to the lower respiratory tract.

[0089] The piezo transducer element can be positioned horizontally between two silicone rings that absorb the vibrations of the element during use. This serves to protect the piezo transducer element, as well as to prevent the vibrations from resonating throughout the housing of the body of the device 100 and the mouthpiece capsule. The configuration of the piezo transducer element and the silicone rings can be enclosed by an atomizer cap. The atomizer cap can be a molded component that is placed directly over the above-mentioned elements, with a hollow cross section in the middle that matches the size of the mesh cross section in the piezo transducer element. This allows for any generated aerosol to flow uninterrupted from the mesh and into the hollow opening in the mouthpiece capsule. The atomizer cap keeps the piezo transducer element configuration in place during use, as well as prevents the configuration from breaking or separating if the device 100 were to be dropped. The atomizer cap fits over the top of the configuration and can be secured via a snap fit.

[0090] The device 100 can include two prong holes located around the piezo transducer element. These prong holes can include an extruded prong component, which can be fabricated from, e.g., a metal material, a plastic material, a silicone material, combinations thereof, or the like. The prong holes can define a hollow component that allows for liquid to flow through them. In some embodiments, the hollow tube can include an absorbent material, which can be in the form of, e.g., a sponge, cloth, wick material, or the like. The prong components are connected to the reservoir located directly underneath the piezo transducer element. The prong holes are connected to the reservoir by, e.g., an open cavity, a hollow tube, or the like, and serve to carry liquid into the reservoir such that it can be aerosolized by the piezo transducer element. The prong components can align with the receiving prong holes on the bottom side of the mouthpiece capsule. When connected, the prong components penetrate the receiving prong holes, enabling the liquid housed in the mouthpiece capsule to flow into the prong components and be directed into the reservoir of the aerosolization chamber.

[0091] The aerosolization chamber includes the reservoir, referred to as the funnel cavity. The reservoir is located directly beneath the mesh cross section of the piezo transducer element, such that with each vibration the mesh contacts the liquid in the reservoir and draws from it droplets of liquid. The volume of the reservoir is minimized by the design. In some embodiments, the reservoir can have a volume of about, e.g., 0.1-1 mL inclusive, 0.1-0.9 mL inclusive, 0.1-0.8 mL inclusive, 0.1-0.7 mL inclusive, 0.1-0.6 mL inclusive, 0.1-0.5 mL inclusive, 0.1-0.4 mL inclusive, 0.1-0.3 mL inclusive, 0.1-0.2 mL inclusive, 0.2-1 mL inclusive, 0.3-1 mL inclusive, 0.4-1 mL inclusive, 0.5-1 mL inclusive, 0.6-1 mL inclusive, 0.7-1 mL inclusive, 0.8-1 mL inclusive, 0.9-1 mL inclusive, 0.1 mL, 0.2 mL, 0.3 mL, 0.4 mL, 0.5 mL, 0.6 mL, 0.7 mL, 0.8 mL, 0.9 mL, 1 mL, or the like. The purpose for minimizing the volume of the reservoir is to maximize the total volume of liquid that can be aerosolized from each capsule. Aerosolization can only occur when the reservoir is full, such that the liquid in the reservoir will be flush against the bottom side of the mesh of the atomizer. In such configuration, the mesh can contact the liquid surface with each oscillation. Once this reservoir is no longer full, the oscillations of the piezo transducer element will not be sufficient for the mesh to generate an aerosol.

[0092] The reservoir can include an absorbent material that is located directly beneath the piezo transducer element. The absorbent material is flush to the bottom side of the piezo transducer element, such that the piezo transducer element is able to draw drops of liquid out of the absorbent material as it undergoes out of plane vibration. The top face of the absorbent material can have a surface area that matches (or substantially matches) the surface area and geometry of the mesh cross section of the piezo transducer element, such that every point on the mesh section of the piezo transducer element is in contact with the absorbent material.

[0093] The mouthpiece capsule includes a cavity for holding an aqueous solution, an opening connected at both ends of the mouthpiece to allow for air flow, and the funnel connector. The funnel connector connects the opening in the mouthpiece to the mesh cross section of the piezo transducer element, such that the generated aerosol will flow directly from the transducer and into the mouthpiece opening where it can be inhaled into the mouth and lungs of the user. The outer shell of the mouthpiece capsule extends below the funnel connector and serves as the primary connection between the mouthpiece capsule and the body of the device 100. The outer shell fits over the lip connector, securing the mouthpiece onto the body of the device 100.

[0094] The mouthpiece capsule houses a liquid which, when attached to the aerosolization chamber, automatically drains into the reservoir beneath the piezo transducer element. The mouthpiece capsule is capable of holding a liquid volume of about, e.g., 1-10 mL inclusive, 1-9 mL inclusive, 1-8 mL inclusive, 1-7 mL inclusive, 1-6 mL inclusive, 1-5 mL inclusive, 1-4 mL inclusive, 1-3 mL inclusive, 1-2 mL inclusive, 2-10 mL inclusive, 3-10 mL inclusive, 4-10 mL inclusive, 5-10 mL inclusive, 6-10 mL inclusive, 7-10 mL inclusive, 8-10 mL inclusive, 9-10 mL inclusive, 1 mL, 2 mL, 3 mL, 4 mL, 5 mL, 6 mL, 7 mL, 8 mL, 9 mL, 10 mL, or the like.

[0095] With respect to the mouthpiece capsule, the circle depicted in the middle of the mouthpiece is the air flow opening. The two half circles depicted on either side represent the receiving prong holes located on the mouthpiece that, when attached to the body of the device 100, attach to the prongs located on the aerosolization chamber. The receiving prong holes can include a silicone ring extending around the opening, such that when the prongs on the aerosolizing system penetrate the receiving prong holes on the mouthpiece, a watertight seal is created to ensure that there is no leakage during the process or attaching or detaching a capsule.

[0096] With reference to FIGS. 1-44, perspective, side, transparent and cross-sectional views of an exemplary aerosol generating device 100 (hereinafter “device 100”) and components that are assembly to achieve the device 100 are provided. The device 100 generally includes a mouthpiece 102 removably coupled or connected to a base assembly 104. The base assembly 104 includes an aerosolization chamber 106. The base assembly 104 can include a base cover or housing 108 configured to at least partially receive therein an inner body 110 (e.g., a stainless steel body). The inner body 110 can support a printed circuit board (PCB) 112 including preprogrammed circuitry for operation of the device 100. FIGS. 19-21 are front, side and rear views of the PCB 112. The PCB 112 can include a processor and a transmitter/receiver capable of receiving and transmitting data to/from the device 100 (e.g., such that communication with a mobile application can be achieved). The base assembly 104 and/or the inner body 110 can support a power source 114 (e.g., a rechargeable battery). [0097] The base assembly 104 and/or the inner body 110 can support an actuator 116 (e.g., a spring-loaded button), coupled to the assembly with a spring 118. In some embodiments, rather than a spring 118, a pressure sensor can be coupled to the actuator 116 and can detect a predetermined threshold pressure applied to the actuator 116. The PCB 112 can include one or more light-emitting diodes (LEDs) 120 aligned with a corresponding opening or slot 122 in the housing 108 such that illumination of the LEDs 120 is visible externally of the device 100. The LEDs 120 can be used to provide visual indication to the user regarding, e.g., the on/off status of the device 100, the power source 114 level, or the like. As will be discussed in greater detail below, the components of the mouthpiece 102 and the aerosolization chamber 106 are aligned (or substantially aligned) along a central longitudinal axis 124 of the device 100. (See, e.g., FIG. 5). Such alignment along the axis 124 ensures a clear, unobstructed travel path for the aerosolized liquid from the aerosolization chamber 106, to the mouthpiece 102, and out of the mouthpiece 102 for inhalation. In particular, the aerosolized liquid travels along a path substantially parallel and along the longitudinal axis 124, ensuring accurate output of the aerosolized liquid to the user.

[0098] With respect to FIGS. 29-34, the mouthpiece 102 includes a substantially cylindrical body 126 extending from a top or uppermost surface 128 of the device 100 to a circumferential edge 130. The body 126 can taper outward from the surface 128 to the edge 130 to provide an ergonomic section for grasping by the user. The mouthpiece 102 includes a coupling section 132 extending from the bottom surface of the body 126 at the edge 130. The coupling section 132 can define an outer diameter dimensioned smaller than the outer diameter at the edge 130, and defines a substantially cylindrical configuration. The coupling section 132 is configured to be at least partially inserted into a corresponding circumferential opening in the body assembly 104 such that the mouthpiece 102 can be removed or coupled relative to the body assembly 104. The base 134 of the coupling section 132 defines the bottommost surface of the mouthpiece 102 opposing the surface 128.

[0099] The mouthpiece 102 includes a hollow opening 136 extending the entire height of the mouthpiece 102, specifically extending from (and through) the surface 128 to the base 134. The opening 136 includes a large diameter opening section 138 at the surface 128, tapering to a small diameter opening section 140, and the section 140 tapering to another large diameter opening section 142 at the base 134 (e.g., funnel-shaped openings at opposing ends). The section 140 can extend at a uniform diameter, while the sections 138, 142 both taper to opposing sides of the section 140. In some embodiments, the diameter of the opening at the section 138 can be about, e.g., 0.36 inches, the diameter of the opening at the section 140 can be about, e.g., 0.11 inches, and the diameter of the opening at the section 142 can be about, e.g., 0.36 inches. The taper at the sections 138, 142 can be at about, e.g., 72 degrees. The opening 136 is generally surrounded by circumferential walls 144 that substantially follow the uniform and tapered configurations of the opening 136. The opening 136 is aligned along the central longitudinal axis 124 of the device 100.

[00100] Circumferentially surrounding the hollow opening 136, the mouthpiece 102 includes a solution containing reservoir 146 (e.g., a solution cavity). The reservoir 146 defines a hollow space with a volume that extends around the walls 144 of the opening 136. Other than the walls of the body 126, the reservoir 146 extends within the entire inner space of the body 126 between the side walls, surface 128, and the bottom surface defined by the edge 130. The reservoir 146 is configured to receive a liquid solution to be aerosolized by the device 100. Each mouthpiece 102 is intended to function as a capsule containing the liquid solution therein. Upon use of the liquid solution in a mouthpiece 102, the mouthpiece 102 can be removed from the device 100 and a new mouthpiece 102 full of the liquid solution can be coupled to the device 100 for further use. Thus, the mouthpiece 102 can be disposable.

[00101] The mouthpiece 102 includes one or more drainage channels 148 (e.g., tubes) formed in the coupling section 132 and extending from the reservoir 146 to the bottommost surface of the base 134. In some embodiments, the mouthpiece 102 can include one drainage channel 148. In some embodiments, the mouthpiece 102 can include two or more drainage channels 148 circumferentially positioned relative to the opening 136 and the central longitudinal axis 124. The channels 148 define a substantially uniform diameter (e.g., about 0.12 inches) along the entire height of the channels 148, and the channels 148 extend substantially parallel to the axis 124. The channels 148 fluidly connect the reservoir 146 to the exterior of the mouthpiece 102 through the base 134.

[00102] The mouthpiece 102 includes a breakable membrane 150 (e.g., a film, thin plastic, or the like) extending over the opening extending into the channels 148 at the base 134. The membrane 150 prevents undesired leakage of the liquid solution from the reservoir 146. Instead, as discussed herein, the membrane 150 maintains the liquid solution within the mouthpiece 102 until the mouthpiece 102 has been coupled to the base assembly 104. The base assembly 104 includes projections that positionally correspond with the channels 148, with the projections at least partially breaking the membrane 150 to allow for drainage of the liquid solution from the mouthpiece 102 and into the aerosolization chamber 106 of the base assembly 104.

[00103] With respect to FIGS. 1-7 and 22-28, the base cover or housing 108 includes two body halves 152, 154 that extend from a top surface 156 to an opposing bottom surface 158. In some embodiments, the outward facing surface of each of the body halves 152, 154 can be substantially semi-circular. The inward facing surfaces of each of the body halves 152, 154 can be substantially planar of flat. The body halves 152, 154 are separated from each other by a vertical slot or gap 160 that extends from the top surface 156 to an inner wall 162 of the base. When viewed from the side (see, e.g., FIG. 28), the gap 160 defines a uniform width along the entire height of the gap 160. The gap 160 is dimensioned complementary to the thickness of the inner body 110 of the device 100, such that the inner body 110 can be releasably inserted into the gap 160 and coupled with the housing 108.

[00104] The outward facing surfaces of the body halves 152, 154 can include inwardly directly fillets 164, 166. The body half 152 includes a substantially circular cutout 168 extending through the wall of the body half 152 and into the gap 160. The cutout 168 is configured and dimensioned complementary to the actuator 116 such that the actuator 116 can be at least partially movably inserted into the cutout 168 for connection with the PCB 112. The inner surfaces of the body halves 152, 154 near the top surface 156 can each include an inwardly directly, semi-circular cutout 170 that together define a substantially cylindrical cutout configured to at least partially receive a portion of the aerosolization chamber 106. The cutouts 170 can taper at section 172 to join or substantially join the width of the gap 160.

[00105] With reference to FIGS. 1-6 and 7-18, the inner body 110 of the device 100 includes a substantially cylindrical top section 174, a tapered or funnel-shaped section 176 circumferentially extending from the bottom surface of the cylindrical top section 174, and an elongated, planar/rectangular section 178 extending from the bottom surface of the cylindrical top section 174. The aerosolization chamber 106 is generally enclosed by at least a portion of the cylindrical top section 174 and the funnel-shaped section 176. The uppermost portion of the top section 174 defines the top surface 180 of the inner body 110, and the bottommost portion of the section 174 defines the base surface 182 of the inner body 110. The top section 174 includes a hollow interior 184 that defines at least a portion of the airway passage or pathway for inhalation of the aerosolized liquid. The inner diameter of the hollow interior 184 is dimensioned to slidably receive therein the outer diameter of the coupling section 132 of the mouthpiece 102. In some embodiments, friction can maintain coupling of the mouthpiece 102 with the section 174. In some embodiments, the device 100 can include a releasable snap/latch system to maintain the mouthpiece 102 coupled to the section 174.

[00106] The aerosolization chamber 106 within the inner body 110 includes a narrowed, stepped opening 186 formed within the cylindrical top section 174. The stepped opening 186 defines a substantially circular or cylindrical configuration, which is configured and dimensioned to receive a disk-shaped aerosolizing element 188. In some embodiments, the aerosolizing element 188 can be of a different configuration (e.g., square, rectangular, oval, or the like). In some embodiments, the aerosolizing element 188 can be about, e.g., 9-15 mm inclusive, 9-14 mm inclusive, 9-13 mm inclusive, 9-12 mm inclusive, 9-11 mm inclusive, 9- 10 mm inclusive, 10-15 mm inclusive, 11-15 mm inclusive, 12-15 mm inclusive, 13-15 mm inclusive, 14-15 mm inclusive, 9 mm, 10 mm, 11 mm, 12 mm, 13 mm, 14 mm, 15 mm, or the like, in diameter. The aerosolizing element 188 can be a piezoelectric transducer element including multiple openings formed therein, thereby creating a mesh-like pattern in the piezoelectric transducer element. In some embodiments, the piezoelectric transducer element can include a piezoceramic ring coupled to a mesh plate (e.g., a metal or silicone plate with a large number of small openings). The piezoceramic ring can be referred to as the piezoceramic material discussed herein, and the mesh plate can be referred to as the micromachined disk.

[00107] As an example, FIG. 42 is a top view of the aerosolizing element 188. The aerosolizing element 188 includes an outer support frame 189 formed from a piezoceramic material surrounding and supporting central micromachined disk 191. The disk 191 includes multiple micro- apertures 193 extending through the disk 191 for aerosolization of the liquid. In some embodiments, the apertures 193 can be circular or cylindrical in shape. In some embodiments, the inner diameter of the apertures 193 can be substantially uniform along the thickness of the disk 191. In some embodiments, the apertures 193 can be conical in configuration such that the inner diameter varies along the thickness of the disk 191. For example, the inner diameter of the apertures 193 can be smaller at the bottom surface of the disk 191, and gradually tapers/increases to a larger inner diameter at the top surface of the disk 191 (or vice versa). Such varying degree of cone angle of the apertures 193 can assist in dispersion and aerosolization of the liquid. In some embodiments, rather than a piezoelectric transducer element, the aerosolizing element 188 can be a micro-electro-mechanical system (MEMS) with associated software that can be used to actuate vibration of a mesh material.

[00108] Directly below the stepped opening 186, the cylindrical top section 174 includes another opening or channel 190 extending from the opening 186. The diameter of the channel 190 is dimensioned smaller than the diameter of the opening 186, ensuring that the step formed due to the difference in diameters supports the aerosolizing element 188. The body 110 includes a hollow reservoir 192 directly below the channel 192. Thus, the opening 186, channel 190, and reservoir 192 are fluidly connected to each other, with each aligned along the central longitudinal axis 124 of the device 100. The reservoir 192 can define a substantially funnel-shaped configuration with a flat top wall, a flat bottom wall 194, and inwardly tapered side walls. The reservoir 192 extends from the section 174 to the section 176. The volume defined by the reservoir 192 can be smaller than the volume defined by the reservoir 146 of the mouthpiece 102.

[00109] The body 110 includes two drainage passages 196 (e.g., hollow tubes) extending from the bottom surface of the hollow interior 184 and into the reservoir 192. The drainage passages 196 are positioned radially on opposing sides of the stepped opening 186. The position of the drainage passages 196 corresponds with the position (and number) of drainage channels 148 of the mouthpiece 102. The top of each drainage passage 196 includes a pointed top 197 configured to at least partially break through the breakable membrane 150 of the mouthpiece 102. (See, e.g., FIG. 5). Thus, upon insertion of the mouthpiece 102 into the hollow interior 184, the pointed tops 197 of the drainage passages 196 at least partially break through the breakable membrane 150 of the drainage channels 148 in the mouthpiece 102, resulting in drainage of at least a portion of the liquid solution in the reservoir 146 into the reservoir 192. As the device 100 is used, the liquid solution can continue to drain from the reservoir 146 into the reservoir 192, until the reservoir 146 of the mouthpiece 102 is fully emptied.

[00110] The aerosolization chamber 106 includes an absorbable element 198 positioned within the reservoir 192. The absorbable element 198 can be, e.g., a sponge, a wicking material, or the like. The absorbable element 198 can be a medical grade material due to contact with the liquid solution to be inhaled by the user in the aerosolized form. The absorbable element 198 can be in the form of a narrow strip vertically oriented within the reservoir 192 and extending from the bottom surface 194 to the bottom surface of the aerosolization element 188. In some embodiments, the cross-sectional area dimension of the absorbable element 198 can be smaller than the surface area of the aerosolization element 198. In some embodiments, the cross-sectional area dimension of the absorbable element 198 can be substantially equal to the surface area of the aerosolization element 198, such that the absorbable element 198 is positioned against the entire surface area of the bottom surface of the aerosolization element 198. In some embodiments, the absorbable element 198 can be in a cylindrical configuration with a diameter of about, e.g., 3-7 mm inclusive, 3-6 mm inclusive, 3-5 mm inclusive, 3-4 mm inclusive, 4-7 mm inclusive, 5-7 mm inclusive, 6-7 mm inclusive, 3 mm, 4 mm, 5 mm, 6 mm, 7 mm, or the like, and a height of about, e.g., 1-8 mm inclusive, 1-7 mm inclusive, 1-6 mm inclusive, 1-5 mm inclusive, 1-4 mm inclusive, 1-3 mm inclusive, 1-2 mm inclusive, 2-8 mm inclusive, 3-8 mm inclusive, 4-8 mm inclusive, 5-8 mm inclusive, 6-8 mm inclusive, 7-8 mm inclusive, 1 mm, 2 mm, 3 mm, 4 mm, 5 mm, 6 mm, 7 mm, 8 mm, or the like.

[00111] The absorbable element 198 remains in the vertical orientation aligned with the axis 124, and is in direct contact with the aerosolization element 198. As liquid solution drains into the reservoir 192, the absorbable element 198 absorbs or wicks a portion of the liquid solution. The absorbable element 198 is configured to absorb the liquid solution along the entire length or height of the absorbable element 198, such that even if the reservoir 192 is only partially full, the liquid solution is contained by the absorbable element 198 to the highest point adjacent to the aerosolization element 188. Such wicking characteristic of the absorbable element 198 ensures that liquid solution is continuously provided to the bottom surface of the aerosolization element 188.

[00112] Thus, the device 100 can be used in an orientation agnostic manner, with the absorbable element 198 continuing to provide liquid solution to the aerosolization element 188. Based on inhalation and/or actuation of the actuator 116, vibration of the aerosolization element 188 is induced. The liquid solution from the absorbable element 198 is aerosolized through the mesh pattern in the aerosolization element 188, and into the opening 136 of the mouthpiece 102. Upon use of some of the liquid solution, the absorbable element 198 continues to wick liquid solution from the reservoir 192 (until the reservoir 192 is emptied), ensuring a continuous supply of liquid solution to the bottom of the aerosolization element 188.

[00113] The section 178 of the body 110 includes a tubular projection 200 extending substantially perpendicularly from the section 178. The hollow interior of the projection 200 is configured to movably receive therein the spring 118 of the actuator 116. Directly behind the projection 200, the body 110 includes an inductor 202 configured to actuate vibration of the aerosolization element 188. The inductor 202 is positioned to detect pressure from the spring 118 (or can include a pressure sensor to detect pressure from the spring 118), which provides the command to initiate vibration of the aerosolization element 188. The inductor 202 can be electrically connected to the PCB 112. In some embodiments, the body 110 can include a power button 204 electrically connected to the PCB 112. In some embodiments, the actuator 116 can act as the power button for operating the device 100. The section 178 includes one or more openings 206 formed in and extending at least partially through the section 178, the openings 206 configured to at least partially receive the PCB 112 and the power source 114. The power source 114 is electrically connected to the PCB 112 to provide power to the device 100. The body 110 can include a threaded bolt or fastener 208 configured to couple the sides of the housing together to prevent opening of the device 100.

[00114] With reference to FIGS. 35-41, the actuator 116 generally includes a curved top surface 210 with substantially oval or circular side walls 212. The bottom surface 214 of the actuator 116 includes an opening or slot 216 configured to engaged with one end of the spring 118. Such engagement ensures that pressure applied to the top surface 210 of the actuator 116 is imparted on the spring 118. The spring 118, in turn, directs the pressure to the inductor 202 (and/or the PCB 112), providing the signal for initiating vibration of the aerosolization element 188.

[00115] During assembly, the inner body 110 is inserted into the gap 160 of the base housing 108. The inner body 110 fits entirely (or substantially entirely) within the gap 160 and cutout 170, such that the top surfaces 180, 156 substantially align. The actuator 116 projects from or is positioned within the cutout 168 in the housing 108 to allow for actuation of the device 100. The coupling section 132 of the mouthpiece 102 can be inserted into the section 174 of the body 110, allowing for the liquid solution to drain from the mouthpiece 102 and into the reservoir 192 of the aerosolization chamber 106. After the device 100 has been used and (over time) the liquid solution has been depleted, the mouthpiece 102 can be discarded and a new mouthpiece 102 full of the liquid solution can be engaged with the base assembly. The alignment of the opening 136 in the mouthpiece 102, the aerosolizing element 188, and the reservoir 192 along the vertical axis 124 of the device 100 creates a linear pathway for the aerosolized particles, resulting in a more direct output. Such direct output and alignment results in a steadier output of the aerosolized particles.

[00116] In some embodiments, the device 100 can be connected to an external device (e.g., a computing device, a mobile device, or the like) to receive and transmit data acquired by the device 100. Such communication can allow for display of collected data regarding use and/or recommendations for further use of the device 100 at a graphical user interface. FIG. 43 is a block diagram of a computing device 300 in accordance with exemplary embodiments of the present disclosure. The computing device 300 includes one or more non- transitory computer-readable media for storing one or more computer-executable instructions or software for implementing exemplary embodiments. The non-transitory computer- readable media may include, but are not limited to, one or more types of hardware memory, non-transitory tangible media (for example, one or more magnetic storage disks, one or more optical disks, one or more flash drives), and the like. For example, memory 306 included in the computing device 300 may store computer-readable and computer-executable instructions or software for implementing exemplary embodiments of the present disclosure (e.g., instructions for operating the device 100). The computing device 300 also includes configurable and/or programmable processor 302 and associated core 304, and optionally, one or more additional configurable and/or programmable processor(s) 302’ and associated core(s) 304’ (for example, in the case of computer systems having multiple processors/cores), for executing computer-readable and computer-executable instructions or software stored in the memory 306 and other programs for controlling system hardware. Processor 302 and processor(s) 302’ may each be a single core processor or multiple core (304 and 304’) processor.

[00117] Virtualization may be employed in the computing device 300 so that infrastructure and resources in the computing device 300 may be shared dynamically. A virtual machine 314 may be provided to handle a process running on multiple processors so that the process appears to be using only one computing resource rather than multiple computing resources. Multiple virtual machines may also be used with one processor. Memory 306 may include a computer system memory or random access memory, such as DRAM, SRAM, EDO RAM, and the like. Memory 306 may include other types of memory as well, or combinations thereof.

[00118] A user may interact with the computing device 300 through a visual display device 318 (e.g., a personal computer, a mobile smart device, or the like), such as a computer monitor, which may display at least one user interface 320 (e.g., a graphical user interface) that may be provided in accordance with exemplary embodiments. The computing device 300 may include other I/O devices for receiving input from a user, for example, a camera, a keyboard, a fingerprint scanner, microphone, or any suitable multi-point touch interface 308, a pointing device 310 (e.g., a mouse). The keyboard 308 and the pointing device 310 may be coupled to the visual display device 318. The computing device 300 may include other suitable conventional I/O peripherals.

[00119] The computing device 300 may also include at least one storage device 324, such as a hard-drive, CD-ROM, eMMC (MultiMediaCard), SD (secure digital) card, flash drive, non-volatile storage media, or other computer readable media, for storing data and computer- readable instructions and/or software that implement exemplary embodiments of the aerosol generating devices described herein. Exemplary storage device 324 may also store at least one database 326 for storing any suitable information required to implement exemplary embodiments. For example, exemplary storage device 324 can store at least one database 326 for storing information, such as data relating to operation of the device 100, frequency of use, the type of liquid solution being used, combinations thereof, or the like, and computer- readable instructions and/or software that implement exemplary embodiments described herein. The databases 326 may be updated by manually or automatically at any suitable time to add, delete, and/or update one or more items in the databases.

[00120] The computing device 300 can include a network interface 312 configured to interface via at least one network device 322 with one or more networks, for example, a Local Area Network (LAN), a Wide Area Network (WAN) or the Internet through a variety of connections including, but not limited to, standard telephone lines, LAN or WAN links (for example, 802.11, Tl, T3, 56kb, X.25), broadband connections (for example, ISDN, Frame Relay, ATM), wireless connections, controller area network (CAN), or some combination of any or all of the above. The network interface 312 may include a built-in network adapter, a network interface card, a PCMCIA network card, Pa Cl/PCIe network adapter, an SD adapter, a Bluetooth adapter, a card bus network adapter, a wireless network adapter, a USB network adapter, a modem or any other device suitable for interfacing the computing device 300 to any type of network capable of communication and performing the operations described herein. Moreover, the computing device 300 may be any computer system, such as a workstation, desktop computer, server, laptop, handheld computer, tablet computer (e.g., the tablet computer), mobile computing or communication device (e.g., the smart phone communication device), an embedded computing platform, or other form of computing or telecommunications device that is capable of communication and that has sufficient processor power and memory capacity to perform the operations described herein.

[00121] The computing device 300 may run any operating system 16, such as any of the versions of the Microsoft® Windows® operating systems, the different releases of the Unix and Linux operating systems, any version of the MacOS® for Macintosh computers, any embedded operating system, any real-time operating system, any open source operating system, any proprietary operating system, or any other operating system capable of running on the computing device and performing the operations described herein. In exemplary embodiments, the operating system 316 may be run in native mode or emulated mode. In an exemplary embodiment, the operating system 316 may be run on one or more cloud machine instances.

[00122] FIG. 44 is a block diagram of an exemplary aerosol generating device/system environment 400 in accordance with exemplary embodiments of the present disclosure. The environment 400 can include servers 402, 404 configured to be in communication with any number of aerosol generating devices 406, 408, at least one processing device 410, a user interface 412, and a central computing system 414 via a communication platform 420, which can be any network over which information can be transmitted between devices communicatively coupled to the network. For example, the communication platform 420 can be the Internet, Intranet, virtual private network (VPN), wide area network (WAN), local area network (LAN), and the like. In some embodiments, the communication platform 420 can be part of a cloud environment.

[00123] The environment 400 can include repositories or databases 416, 418, which can be in communication with the servers 402, 404, as well as the devices 406, 408, at least one processing device 410, user interface 412, and central computing system 414, via the communications platform 420. In exemplary embodiments, the servers 402, 404, the devices 606, 608, at least one processing device 410, user interface 412, and central computing system 414 can be implemented as computing devices (e.g., computing device 300). Those skilled in the art will recognize that the databases 416, 418 can be incorporated into at least one of the servers 402, 404. In some embodiments, the databases 416, 418 can store data relating to operation of the device 100, and such data can be distributed over multiple databases 416, 418.

[00124] While exemplary embodiments have been described herein, it is expressly noted that these embodiments should not be construed as limiting, but rather that additions and modifications to what is expressly described herein also are included within the scope of the invention. Moreover, it is to be understood that the features of the various embodiments described herein are not mutually exclusive and can exist in various combinations and permutations, even if such combinations or permutations are not made express herein, without departing from the spirit and scope of the invention.

Claims

CLAIMS:

1. An aerosol generating device, comprising: a mouthpiece including (i) a reservoir capable of receiving a liquid solution, and (ii) an opening extending through the mouthpiece; and a base assembly configured to be removably coupled to the mouthpiece, the base assembly including: an aerosolization chamber configured to receive the liquid solution from the reservoir of the mouthpiece; and an aerosolization element disposed in the aerosolization chamber, the aerosolization element is capable of aerosolizing the liquid solution for inhalation through the opening of the mouthpiece.

2. The aerosol generating device of claim 1, wherein the opening of the mouthpiece, the aerosolization chamber, and the aerosolization element are aligned along a central longitudinal axis of the aerosol generating device.

3. The aerosol generating device of claim 1, wherein the opening of the mouthpiece includes a first large diameter section at a top surface of the mouthpiece, a second large diameter section at a bottom surface of the mouthpiece, and a narrow diameter section connecting the first and second large diameter sections.

4. The aerosol generating device of claim 3, wherein the first and second large diameter sections both include tapered walls towards the narrow diameter section.

5. The aerosol generating device of claim 1, wherein the reservoir of the mouthpiece circumferentially surrounds the opening of the mouthpiece.

6. The aerosol generating device of claim 1, wherein the mouthpiece includes at least one drainage channel extending from the reservoir.

7. The aerosol generating device of claim 6, wherein the mouthpiece includes a breakable membrane covering an opening associated with the at least one drainage channel to prevent flow of the liquid solution from the mouthpiece.

36 The aerosol generating device of claim 1, wherein the aerosol generating device is capable of being used in an orientation agnostic manner, with the aerosolization element capable of aerosolizing the liquid solution in any orientation of the aerosol generating device. The aerosol generating device of claim 1, wherein the base assembly includes a printed circuit board and a power source for actuation of the aerosolization element. The aerosol generating device of claim 1, wherein the base assembly includes an actuator configured to receive a force for initiation of aerosolization of the liquid solution. The aerosol generating device of claim 1, wherein the base assembly includes at least one drainage passage fluidly connected to a solution reservoir of the aerosolization chamber. The aerosol generating device of claim 11, wherein the at least one drainage passage includes a feature configured to at least partially break a breakable membrane of the mouthpiece to release flow of the liquid solution from the mouthpiece, through the at least one drainage passage, and into the solution reservoir of the aerosolization chamber. The aerosol generating device of claim 11, comprising an absorbable element disposed within the solution reservoir, the absorbable element configured to absorb at least some of the liquid solution within the solution reservoir. The aerosol generating device of claim 13, wherein the absorbable element is a medical grade sponge. The aerosol generating device of claim 13, wherein the absorbable element is oriented to abut a bottom surface of the solution reservoir at one end and abut a bottom surface of the aerosolization element at an opposing end. The aerosol generating device of claim 1, wherein the base assembly includes a stepped opening dimensioned to support the aerosolization element.

37 A method of generating aerosol, comprising: removably coupling a mouthpiece of an aerosol generating device to a base assembly of the aerosol generating device, the mouthpiece including (i) a reservoir capable of receiving a liquid solution, and (ii) an opening extending through the mouthpiece, and the base assembly including (i) an aerosolization chamber, and (ii) an aerosolization element disposed in the aerosolization chamber; draining the liquid solution from the reservoir of the mouthpiece into the aerosolization chamber of the base assembly; and activating the aerosolization element to aerosolize the liquid solution for inhalation through the opening of the mouthpiece. The method of claim 17, wherein the mouthpiece includes at least one drainage channel extending from the reservoir with a breakable membrane covering an opening associated with the at least one drainage channel, and the base assembly includes at least one drainage passage fluidly connected to a solution reservoir of the aerosolization chamber. The method of claim 18, wherein removably coupling of the mouthpiece with the base assembly at least partially breaks the breakable membrane of the mouthpiece with a feature of the at least one drainage passage of the base assembly to allow for draining of the liquid solution from the reservoir of the mouthpiece into the aerosolization chamber of the base assembly. An aerosol generating system, comprising: an aerosol generating device including a mouthpiece and a base assembly configured to be removably coupled to the mouthpiece, the mouthpiece including (i) a reservoir capable of receiving a liquid solution, and (ii) an opening extending through the mouthpiece, and the base assembly including (i) an aerosolization chamber configured to receive the liquid solution from the reservoir of the mouthpiece, and (ii) an aerosolization element disposed in the aerosolization chamber, the aerosolization element is capable of aerosolizing the liquid solution for inhalation through the opening of the mouthpiece; and an external device including a graphical user interface, the external device capable of receiving and processing data associated with implementation of the aerosol generating device. An aerosol generating device, comprising: a mouthpiece including an opening extending through the mouthpiece; and a base assembly coupled to the mouthpiece, the base assembly including: an aerosolization chamber configured to receive a liquid solution; an aerosolization element, the aerosolization element is capable of aerosolizing the liquid solution for inhalation through the opening of the mouthpiece; and an absorbable element disposed within the aerosolization chamber and positioned in constant fluid communication with the aerosolization element, the absorbable element is capable of providing constant supply of the liquid solution in the aerosolization chamber to the aerosolization element. A method of generating aerosol, comprising: removably coupling a mouthpiece of an aerosol generating device to a base assembly of the aerosol generating device, the mouthpiece including an opening extending through the mouthpiece, and the base assembly including (i) an aerosolization chamber configured to receive a liquid solution, (ii) an aerosolization element, and (iii) an absorbable element disposed within the aerosolization chamber and positioned in constant fluid communication with the aerosolization element; providing a constant supply of the liquid solution from the aerosolization chamber to the aerosolization element with the absorbable element; and activating the aerosolization element to aerosolize the liquid solution for inhalation through the opening of the mouthpiece. An aerosol generating system, comprising: an aerosol generating device including a mouthpiece and a base assembly coupled to the mouthpiece, the mouthpiece including (i) an opening extending through the mouthpiece, and the base assembly including (i) an aerosolization chamber configured to receive a liquid solution, (ii) an aerosolization element, the aerosolization element is capable of aerosolizing the liquid solution for inhalation through the opening of the mouthpiece, and (iii) an absorbable element disposed within the aerosolization chamber and positioned in constant fluid communication with the aerosolization element, the absorbable element is capable of providing constant supply of the liquid solution in the aerosolization chamber to the aerosolization element; an external device including a graphical user interface, the external device capable of receiving and processing data associated with implementation of the aerosol generating device.