EP3167456B1 - Behälter, verfahren zur herstellung davon und zielanordnung zur herstellung von radioisotopen mithilfe solch eines behälters - Google Patents

Behälter, verfahren zur herstellung davon und zielanordnung zur herstellung von radioisotopen mithilfe solch eines behälters Download PDF

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EP3167456B1
EP3167456B1 EP15736824.2A EP15736824A EP3167456B1 EP 3167456 B1 EP3167456 B1 EP 3167456B1 EP 15736824 A EP15736824 A EP 15736824A EP 3167456 B1 EP3167456 B1 EP 3167456B1
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Prior art keywords
container
target
target assembly
fraction
matrix
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English (en)
French (fr)
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EP3167456A1 (de
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Milo CONARD
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Nanomarker Sprl
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Nanomarker Sprl
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    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
    • G21K5/00—Irradiation devices
    • G21K5/08—Holders for targets or for other objects to be irradiated
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D1/00—Electroforming
    • C25D1/003—3D structures, e.g. superposed patterned layers
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
    • G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H13/00—Magnetic resonance accelerators; Cyclotrons
    • H05H13/005—Cyclotrons
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H6/00—Targets for producing nuclear reactions
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G21G2001/0015—Fluorine

Definitions

  • the invention relates to a container usable for the production of radioisotopes, to a method for obtaining such a container, and to a target assembly comprising such a container.
  • radioisotope It is known to produce a radioisotope by irradiating a target containing a precursor of the radioisotope by means of a particle beam.
  • 18 F is produced by irradiation with a proton beam of a target material containing 18 O enriched water.
  • a particle accelerator such as a cyclotron or linac, is used to produce the particle beam.
  • the target comprises a container having a chamber or cavity, generally closed by a window that allows the passage of the beam, without it being substantially weakened. This window must be as thin as possible, but must withstand the thermal, mechanical and radiation stresses to which it is subjected in operation.
  • the power dissipated in the target during the irradiation by a particle beam is given by the product of the energy of the particles by the current of this beam. This power can be very important.
  • the target is usually cooled by energetic means such as water circulation.
  • the target may be disposed outside the cyclotron.
  • This solution facilitates the construction of the target and allows easy access to it, especially for the cooling means.
  • it requires that the beam be extracted from the accelerator, which presents many difficulties.
  • the various known extraction means such as stripping, the electrostatic deflector, or magnetic, the self extraction, each have known difficulties as well. Extraction by stripping is relatively easy, but uses negative ions, less stable during acceleration, more difficult to produce, and requiring a greater vacuum.
  • the deflectors generally comprise a septum and a high voltage electrode, whose function is to separate the last turn of the beam from the previous one.
  • the septum which heats up, is activated, and can be damaged.
  • the beam can be directed to the target, and the size, angle, and impact position of the beam on the target can be controlled.
  • Another solution is to place the target inside the cyclotron. It is not necessary to extract the beam.
  • the target is placed in the peripheral region of the median plane of the cyclotron.
  • the beam which traverses quasi-circular orbits of increasing radii, presents a certain width, and each tower is separated from the preceding by a certain distance. This distance can be reduced to the point where the beam constitutes a kind of continuous web in the median plane of the cyclotron.
  • a fraction of the beam or ply, located radially outward then strikes the target, while the fraction of the beam or the ply located radially inward continues its course in the machine. This technique is used widely and successfully in the case of solid targets.
  • the document WO2013049809 discloses a target set for producing radioisotopes for the synthesis of radiopharmaceuticals from a liquid precursor.
  • the target represented in Fig.1 comprises a container 10 having a chamber 12 adapted to contain a precursor material of the desired radioisotope.
  • a thin cover sheet 14 made of a beam permeable material covers the chamber and is secured to the container so as to seal the chamber by means of a front clamp 16 and a rear clamp 18.
  • a channel 24 allows access to the chamber 12 for filling or emptying the precursor material.
  • Other modes of joining can be envisaged, such as welding or brazing.
  • the center of the cyclotron is represented by the point O, and the arrow A represents a beam of particles traveling through a tower or an orbit with a radius less than the radial position of the target. This beam will continue its course in the cyclotron, and reappear with increased energy and a larger radius.
  • Arrow B represents an outer turn, tangentially hitting the target's cover sheet. Part of this beam interacts with the precursor contained in the chamber, but with the cover sheet 14, thus losing its energy without producing any useful effect.
  • Arrow C represents an even more external turn, which enters the chamber 12 and interacts with the precursor of the radioisotope it contains. It can be seen that there is an optimal orientation for the target assembly, minimizing the lost beam fraction in the tangential edge of the window 14.
  • the spherical shape chosen is the one that gives the best resistance to pressure, the stresses being distributed in a uniform.
  • the thickness required to allow forming and welding of the two hemispheres and the two tubes results in the beam losing a significant portion of its energy during the crossing, which generates heat, and requires additional cooling. the beam penetration zone.
  • This additional cooling is achieved by a circulation of water, which requires the aluminum window and the sheet of water, which in turn causes a loss of energy and a production of heat. Due to the need for this additional cooling, this target is not suitable for use as an internal target.
  • This target requires a relatively high proton energy (19 MeV) to allow a significant production of 18 F because the energy loss of these protons in the cooling system and the container wall is about 8 MeV.
  • An object of the invention is to provide a container usable for the production of radioisotopes, a method of obtaining such a container, and a target assembly comprising such a container, which is reliable, easy to assemble and to use, and which has a very good transparency to the particle beam.
  • the invention is defined by the independent claims. The dependent claims define preferred embodiments of the invention.
  • the container for the production of radioisotopes by irradiation of a precursor material.
  • the container consists of a metal envelope in one piece, the wall of said envelope having a thin fraction, with a thickness of between 5 and 100 ⁇ m, the balance having a thickness greater than 100 ⁇ m. .
  • said envelope has a symmetry of revolution, said thin fraction extending over a fraction of the height of the envelope.
  • the container may comprise at least one end having a conical shape, the base of the cone being oriented outwards of the container.
  • One end of said envelope can be closed.
  • the thin fraction may have an outer diameter of between 4 mm and 100 mm.
  • the container may consist, at least in part, of at least one of the metals selected from nickel, titanium, niobium, tantalum and stainless steels. Alloys such as Havar®, Invar® and Kovar® are also preferred. Alloys having a low coefficient of thermal expansion are advantageous in the case of rotating targets.
  • the matrix may advantageously be removed by dissolution.
  • a set of target for the production of radioisotopes comprising a container according to the invention, and comprising a support tube comprising at one end a threaded portion, and a ring comprising a adapted internal thread, the support tube and the ring being configured to grip the container.
  • the support tube can then advantageously have a conical end congruent to the end of the container, and the ring have a conical end congruent to the end of the container.
  • the tube of The carrier and the container are rotatably mounted about an axis and the target assembly includes a motor arranged to rotate the support tube and the container.
  • the target assembly may comprise a cooling tube disposed inside the container, arranged to allow the circulation of a cooling liquid.
  • the cooling tube may comprise, at its lower end, a cooling head, which may have on a part of its periphery capable of receiving the beam, a recess, which gives the incident beam a longer path in a precursor liquid.
  • the target set according to the invention can be used as an internal target for a cyclotron or as an external target. It can also be used as a beam stop.
  • Fig. 1 is a sectional view of a container of the prior art, namely that of WO2013049809 and has been described above.
  • the Fig. 2 is a perspective view of a container 100 according to the invention.
  • This container 100 is in the form of a "thimble" having a symmetry of revolution about an axis.
  • the upper part 110 is open and may have a conical shape, the opening of the cone being oriented upwards. As explained below, this arrangement is of interest for assembling the container 100 in a target set.
  • a first cylindrical portion 120 is connected upwardly to the upper portion 110 and down to a thin-walled portion 130.
  • This thin-walled portion 130 is connected to a second cylindrical portion 140, which in turn connects to a cupola 150 closing the container 100 from below.
  • the thickness of the thin fraction is less than or equal to 100 ⁇ m, for example 80, 60, 40.20, 10 or even 5 ⁇ m.
  • the non-thinned portions namely the open top 110, the first 120 and the second 140 cylindrical portion and the cupola 150 are made in a thickness greater than the thickness of the thin wall fraction 130.
  • the non-thinned portions may have a thickness greater than or equal to 100 microns, for example 200 microns or more.
  • the various parts of the container 100 are connected to each other without sharp angles, so that a better mechanical resistance, especially at the pressure, is obtained.
  • the inside diameter may be of the order of 10 mm, the total height of 11 mm, the angle of the cone may be 30 °.
  • the container 100 has been shown in cylindrical form. However, it is possible, within the scope of the present invention, to produce a container 100 having a more complex shape, with an inward curvature, such as a hyperboloid to a web, or a swollen shape, such as a barrel.
  • the container 100 has been shown with an opening up and a closed side down. However, it is conceivable, without departing from the scope of the invention, a container 100 having two openings as shown. There is then a container 100 which can be supplied with target material from above or from below, and in which a flow of coolant or precursor fluid passing through the container 100 from top to bottom can be achieved.
  • the choice of the thickness of the thin portion 130 is an important element of the invention.
  • the residual energy of a proton beam having an energy of 7, 10, 15, 20, and 30 MeV after passing through a nickel sheet of various thicknesses has been indicated. It can be seen that when the sheet has a thickness of 5 ⁇ m, the energy loss of the protons is negligible, namely, 3% at 7 MeV, and less than 0.2% at 30 MeV. On the other hand, at 100 ⁇ m, and low energy, the loss in the sheet is substantial. It is then necessary to use an accelerator at higher energy and therefore more expensive. It is known that the production yield of 18 F from H 2 18 O by reaction (p, n) is practically zero when the protons have an energy less than 3 MeV.
  • the Fig. 3 is an exploded view and perspective view of the lower portion of a target assembly according to the invention and shows how the container 100 is arranged to a support tube 200.
  • the tube has a male threaded portion 220.
  • a ring 300 presents a corresponding female threaded portion 310.
  • the ring covers the upper part 110 of the container 100 and apply it against the lower part of the support tube 200.
  • At least the thin wall fraction 130 of the container 100 then emerges from the assembly and form.
  • the support tube 200 and the ring 300 may comprise flats 210, 320 which then allow an operator to assemble and disassemble the assembly very quickly by means of two flat keys.
  • the support tube 200 and the ring 300 may be made for example of stainless steel.
  • the lower part of the support tube 200 has a conical end 230 congruent with the conical portion 110 of the container 100, itself congruent a conical end 330 of the ring 300.
  • an excellent seal can be obtained without having to resort to a seal: the sealing is ensured by the metal-to-metal contact.
  • the Fig. 4 is a sectional view of the lower part of a target assembly according to the invention.
  • the assembly "glove finger” 400 which has the dual function of cooling the precursor material contained in the container and which in turn cools the container, and to allow the loading or unloading of the material precursor in the container.
  • a cooling tube 410 closed at its lower end can be inserted into the support tube 200 and end up in the container 100.
  • the container 100 has an internal diameter of 10 mm, and a height of 10 mm
  • the cooling tube 410 has an outer diameter of 8 mm
  • the irradiation chamber 440 having a working volume of approximately 350 mm 3 .
  • An intermediate tube 420 open at its lower end 425, and of smaller diameter than that of the cooling tube is inserted therein. It is thus possible to circulate a cooling liquid such as water in the space between this cooling tube 410 and this inner tube 420.
  • the arrows A represent the coolant inlet and the arrows B the exit of cooling liquid. Circulation directions A and B can be reversed.
  • the heat exchange surface being large and evenly distributed, this arrangement allows excellent cooling.
  • the assembly "glove finger" 400 remains fixed. The relative movement of these two sets produces a stirring which further improves the cooling, inducing a forced convection.
  • a capillary tube 430 placed axially inside the intermediate tube 420, and sealingly crossing the lower end of the cooling tube 410 to end in the space between the container 100 and the cooling tube 410 allows the loading and unloading of the precursor material as indicated by the bidirectional arrow C. It is shown in enlarged view how the conical portion 110 of the container is sandwiched between the conical end of the ring 330 and the conical end of the support tube 230, thus ensuring the seal without the use of a seal.
  • the target set of the invention is used as an internal target or as an external target, it is advantageous to be able to rotate it. It can be given successively different orientations, for example, a rotation of 10 ° for each use, or preferably, ensure a continuous rotation of the container 100 during the irradiation. It is thus possible to ensure that the entire periphery of the thin wall fraction is traversed by the beam, which ensures a better distribution of heat production over a larger area.
  • the rotation induces stirring of the precursor material, which improves the convection cooling.
  • the Fig. 5 is an axial and perspective sectional view of the upper portion 500 of a target assembly according to the invention, in one embodiment for rotating the container 100.
  • the container 100 (not shown in the figure) and the support tube 200 are arranged in the rotor 570 of an electric motor.
  • the stator 560 is secured to a support case 510 which is fixed. Maintaining and sealing are provided by a bearing-seal having a fixed portion 540 and a rotating portion 542.
  • This bearing-seal may include ball bearings 550 and 550 '.
  • This seal may be for example a ferrofluidic joint such as those provided by Rigaku.
  • the dispensing head of the thermowell 400 emerges at the top of the target assembly and provides access to the inlet or outlet ports 452, 454 for cooling liquid and 430 filling / emptying of the precursor material. There may be two tubes for separate input and output.
  • Figs 6a and 6b a cyclotron 700 in which a set of target according to the invention is arranged.
  • the upper part 500 emerges from the upper face of the cyclotron 700.
  • the support tube 200 has a length such that the container 701 is in the median plane of the cyclotron, the thin fraction of which is exposed to the beam, as shown in detail view 6c.
  • the target assembly of the invention When used as an external target, it can be arranged at the end of the beam line, and receive it radially. It is also possible to produce a container whose thin part is located on the base, such as the containers 907 and 909 shown in FIG. fig.8 and orient the beam towards this base, parallel to the axis of symmetry of the container.
  • FIGS. Figs 7a and 7b wherein the volume of the chamber is even smaller.
  • the Fig. 7a is a perspective view of the lower end of a cooling head 800 of a thimble of this preferred mode. This tube has a face 801 having an optimized profile as discussed below.
  • the coolant inlet / outlet ports 802 make it possible to circulate the coolant inside the cooling head 800.
  • the inlet / outlet ports of the precursor liquid 803 open below the lower end of the cooling head 800 and provide access to the space between the container and the cooling head 800. Notches or grooves 804 may be provided for the placement of temperature probes eg thermocouples.
  • the Fig. 7b is a top view of a section perpendicular to the axis of this cooling head 800 in position in a container 860.
  • the cooling head 800 has on a part of its periphery, a recess 851, which gives the incident beam, represented by the arrows F, a greater path 852 in the precursor liquid, while the space between the cooling head 800 and the container 860 is smaller where there is no incident beam.
  • the length of this path is determined so that the beam can deposit all its useful energy in the precursor material.
  • This arrangement has the following advantages: reducing the volume of precursor required; maximizing cooling, due to a minimum liquid thickness; use of all useful energy (eg energy above 4 MeV for protons in H 2 18 O) beam particles in the precursor.
  • Thermocouples 805 provide real-time temperature control of the target.
  • the container 860 is in rotation, while the cooling head 800 is fixed, which promotes the mixing of the precursor liquid, and the heat exchange.
  • the inside diameter of the container 860 is 10 mm
  • the outside diameter of the cooling head is 9.5 mm
  • the useful volume of the chamber is 100 mm 3 .
  • Fig. 9 shows sectional views of a plurality of embodiments of containers according to the invention.
  • the arrow X represents the direction of the incident beam.
  • the X arrow also indicates the position of the thin wall.
  • the cuts are limited to the facial section of the solids so as to facilitate the representation of the thin walls.
  • the container 901, symmetrical of revolution, cylindrical, and conical top end is one of the preferred embodiments of the invention.
  • the container 902, symmetrical of revolution has two open ends, both of conical shape.
  • the containers 903 and 904 are similar to the container 901, except they have an open end with a flat edge and an open end with a cylindrical edge, respectively.
  • the container 905 is similar to the container 901, except that it has a shape of "barrel"
  • the container 906 is similar to the container 901, except that it has a hyperboloid shape to a web.
  • the container 907 is similar to the container 901, except that it has a thin wall on the closed end. It thus allows axial penetration of the beam.
  • the container 908, unlike the other containers shown, has no symmetry of revolution, but a square or rectangular section, the thin wall may extend over a portion of two or three faces. This container is also represented in a cavalier perspective.
  • the container 910 is similar to the container 901, except that it has a larger diameter, for example 50 mm, and a flat bottom.
  • the container 909 is similar to the container 910, except that the thin portion is arranged in a ring on the flat bottom and allows axial penetration of the beam.
  • This container can advantageously be used in an external target, in which the incident beam is parallel to the axis of rotation, as represented by the arrow X.
  • the targets 901 to 907 can be arranged in such a way that the beam penetrates radially into the target.
  • the container 100 according to the invention has the advantage of being in one piece, that is to say not requiring any means of assembly, or assembly or disassembly work.
  • the thin fraction 130 of the container 100 constitutes, as it were, a window integrated in the container 100.
  • the target and the container 100 according to the invention allow easy disassembly and reassembly. The operator can act quickly and can therefore limit his exposure to radiation.
  • the container of the invention requires little material. It is therefore expensive and has little waste when it needs to be disposed of.
  • the target assembly according to the invention may incidentally serve as a beam stop, for example during the development of an accelerator.
  • the use of the words up / down bottom / top is to be understood as being related to the orientation of the components shown in the drawings.
  • the invention can be applied to other liquid precursors, such as than the ordinary water H 2 16 O which produces 13 N during the irradiation with protons, or gaseous such as 14 N 2 , to obtain 11 C.
  • the invention also applies to the case of a precursor material such as 11 B 2 O 3 , which produces 11 C by reaction (p, n) and form of 11 CO 2 that can be collected.
  • Other particles can be used, such as deuterons and alpha particles.
  • the target according to the invention can be used, the chamber of the container being at atmospheric pressure, or the chamber being kept under pressure.

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Claims (16)

  1. Behälter (100, 901, 902, 903, 904, 905, 906, 907, 908, 909, 910) zur Herstellung von Radioisotopen durch Bestrahlung eines Vorläufermaterials, dadurch gekennzeichnet, dass er von einer metallischen Hülle aus einem Stück gebildet ist, wobei die Wand der Hülle einen dünnen Abschnitt (130) mit einer Dicke zwischen 5 und 100 µm aufweist, wobei der Rest eine Dicke von über 100 µm aufweist.
  2. Behälter (100, 901, 902, 903, 904, 905, 906, 907, 909, 910) nach Anspruch 1, dadurch gekennzeichnet, dass die Hülle eine Umdrehungssymmetrie aufweist, wobei sich der dünne Abschnitt auf einem Abschnitt der Höhe der Hülle erstreckt.
  3. Behälter (100, 901, 902, 905, 906, 907, 908, 909, 910) nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass er mindestens ein Ende umfasst, das eine konische Form aufweist, wobei die Basis des Konus zum Außenbereich des Behälters gerichtet ist.
  4. Behälter (100, 901, 903, 904, 905, 907, 908, 909, 910) nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass ein Ende der Hülle geschlossen ist.
  5. Behälter (100, 901, 902, 903, 904, 905, 906, 907, 908, 909, 910) nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass der dünne Abschnitt einen Außendurchmesser zwischen 4 mm und 100 mm aufweist.
  6. Behälter (100, 901, 902, 903, 904, 905, 906, 907, 908, 909, 910) nach einem der vorhergehenden Ansprüche, dadurch gekennzeichnet, dass er zumindest teilweise von mindestens einem der Metalle gebildet ist, die ausgewählt sind unter Nickel, Titan, Niobium, Tantal, Eisen, Chrom, Kobalt und den rostfreien Stählen.
  7. Verfahren zur Herstellung eines Behälters (100, 901, 902, 903, 904, 905, 906, 907, 908, 909, 910) nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, dass es die folgenden Schritte umfasst:
    - Bereitstellen einer Matrix;
    - Elektroabscheidung einer Dicke eines metallischen Materials auf die Matrix, bis eine erste Dicke zwischen 5 µm und 100 µm erhalten wird;
    - Verdecken eines Abschnitts der Oberfläche der Matrix;
    - Elektroabscheidung auf dem nicht verdeckten Abschnitt, bis eine Dicke über 100 µm erhalten wird;
    - Beseitigen der Matrix.
  8. Verfahren nach Anspruch 7, dadurch gekennzeichnet, dass die Matrix durch Auflösung beseitigt wird.
  9. Zielanordnung zur Herstellung von Radioisotopen, umfassend einen Behälter (100, 901, 902, 903, 904, 905, 906, 907, 908, 909, 910) nach einem der Ansprüche 1 bis 6, und umfassend ein Stützrohr (200), umfassend an einem Ende einen Gewindeabschnitt (220) und einen Ring (300), umfassend ein entsprechendes Innengewinde (310), wobei das Stützrohr (200) und der Ring (300) eingerichtet sind, um den Behälter einzuspannen.
  10. Zielanordnung nach Anspruch 9, dadurch gekennzeichnet, dass der Behälter (100, 901, 902, 905, 906, 907, 908, 909, 910) ein Ende aufweist, das eine konische Form aufweist, wobei die Basis des Konus zum Außenbereich des Behälters gerichtet ist, dass das Stützrohr (200) ein mit dem Ende des Behälters kongruentes konisches Ende aufweist, und dass der Ring (300) ein mit dem Ende des Behälters kongruentes Ende aufweist.
  11. Zielanordnung nach einem der Ansprüche 9 bis 10, dadurch gekennzeichnet, dass das Stützrohr (200) und der Behälter drehbar um eine Achse montiert sind, und dass die Zielanordnung einen Motor (560, 570) umfasst, der eingerichtet ist, um das Stützrohr (200) und den Behälter in Drehung zu versetzen.
  12. Zielanordnung nach einem der Ansprüche 9 bis 11, dadurch gekennzeichnet, dass sie ein Kühlrohr (410) umfasst, das im Inneren des Behälters angeordnet und eingerichtet ist, um die Zirkulation einer Kühlflüssigkeit zu ermöglichen.
  13. Zielanordnung nach Anspruch 12, dadurch gekennzeichnet, dass das Kühlrohr (410) an seinem Ende einen Kühlkopf (800) umfasst, der auf einem Teil seiner Peripherie, die den Strahl aufnehmen kann, eine Verstärkung (851) aufweist, die dem eintreffenden Strahl einen größeren Weg (852) in einer Vorläuferflüssigkeit verleiht.
  14. Verwendung der Zielanordnung nach einem der Ansprüche 9 bis 13 als internes Ziel eines Zyklotrons (700).
  15. Verwendung der Zielanordnung nach einem der Ansprüche 9 bis 13 als externes Ziel.
  16. Verwendung der Zielanordnung nach einem der Ansprüche 9 bis 13 als Strahlblocker.
EP15736824.2A 2014-07-10 2015-07-09 Behälter, verfahren zur herstellung davon und zielanordnung zur herstellung von radioisotopen mithilfe solch eines behälters Active EP3167456B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BE2014/0551A BE1023217B1 (fr) 2014-07-10 2014-07-10 Conteneur, son procede d'obtention, et ensemble de cible pour la production de radio-isotopes utilisant un tel conteneur
PCT/EP2015/065687 WO2016005492A1 (fr) 2014-07-10 2015-07-09 Conteneur, son procédé d'obtention, et ensemble de cible pour la production de radio-isotopes utilisant un tel conteneur

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US9961756B2 (en) * 2014-10-07 2018-05-01 General Electric Company Isotope production target chamber including a cavity formed from a single sheet of metal foil
US10354771B2 (en) 2016-11-10 2019-07-16 General Electric Company Isotope production system having a target assembly with a graphene target sheet
US11443868B2 (en) * 2017-09-14 2022-09-13 Uchicago Argonne, Llc Triple containment targets for particle irradiation
US11315700B2 (en) * 2019-05-09 2022-04-26 Strangis Radiopharmacy Consulting and Technology Method and apparatus for production of radiometals and other radioisotopes using a particle accelerator
CZ309802B6 (cs) * 2021-04-16 2023-10-25 Extreme Light Infrastructure ERIC (ELI ERIC) Jaderný terčík, způsob indukce jaderné reakce s tímto jaderným terčíkem a zařízení na výrobu radioizotopů s tímto jaderným terčíkem

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BE1023217B1 (fr) 2016-12-22
US20170213614A1 (en) 2017-07-27
CA2957639C (en) 2023-02-21
CN106716548A (zh) 2017-05-24
US10854349B2 (en) 2020-12-01
CN106716548B (zh) 2019-03-15
CA2957639A1 (en) 2016-01-14
WO2016005492A1 (fr) 2016-01-14
EP3167456A1 (de) 2017-05-17

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