EP3167456A1 - Conteneur, son procédé d'obtention, et ensemble de cible pour la production de radio-isotopes utilisant un tel conteneur - Google Patents
Conteneur, son procédé d'obtention, et ensemble de cible pour la production de radio-isotopes utilisant un tel conteneurInfo
- Publication number
- EP3167456A1 EP3167456A1 EP15736824.2A EP15736824A EP3167456A1 EP 3167456 A1 EP3167456 A1 EP 3167456A1 EP 15736824 A EP15736824 A EP 15736824A EP 3167456 A1 EP3167456 A1 EP 3167456A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- container
- target
- target assembly
- thickness
- matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21K—TECHNIQUES FOR HANDLING PARTICLES OR IONISING RADIATION NOT OTHERWISE PROVIDED FOR; IRRADIATION DEVICES; GAMMA RAY OR X-RAY MICROSCOPES
- G21K5/00—Irradiation devices
- G21K5/08—Holders for targets or for other objects to be irradiated
-
- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D1/00—Electroforming
- C25D1/003—3D structures, e.g. superposed patterned layers
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
- G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H13/00—Magnetic resonance accelerators; Cyclotrons
- H05H13/005—Cyclotrons
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H6/00—Targets for producing nuclear reactions
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0015—Fluorine
Definitions
- Container its method of obtaining, and target set for the production of radioisotopes using such a container
- the invention relates to a container for use in the production of radioisotopes, to a method for obtaining such a container, and to a target assembly comprising such a container.
- radioisotope It is known to produce a radioisotope by irradiating a target containing a precursor of the radioisotope by means of a particle beam.
- 18 F is produced by irradiation with a proton beam of a target material containing 18 O enriched water.
- a particle accelerator such as a cyclotron or a linac, is used for the production of the particle beam.
- the precursor of the radioisotope is a liquid or a gas
- the target comprises a container comprising a chamber or cavity, generally closed by a window which allows the passage of the beam, without it being weakened.
- This window must be as thin as possible, but must withstand the thermal, mechanical and radiation stresses to which it is subjected in operation.
- the power dissipated in the target during the irradiation by a particle beam is given by the product of the energy of the particles by the current of this beam. This power can be very important.
- the target is usually cooled by energetic means such as water circulation.
- the target may be disposed outside the cyclotron.
- This solution facilitates the construction of the target and allows easy access to it, especially for the cooling means.
- it requires that the beam be extracted from the accelerator, which presents many difficulties.
- the various known extraction means such as stripping, the electrostatic deflector, or magnetic, the self extraction, each have known difficulties as well. Extraction by stripping is relatively easy, but uses negative ions, less stable during acceleration, more difficult to produce, and requiring a greater vacuum.
- the deflectors generally comprise a septum and a high voltage electrode, whose function is to separate the last turn of the beam from the previous one.
- the beam when the beam has been extracted, it can be directed to the target, and the size, angle, and impact position of the beam on the target can be controlled.
- Another solution is to place the target inside the cyclotron. It is not necessary to extract the beam.
- the target is placed in the peripheral region of the median plane of the cyclotron.
- the beam which traverses quasi-circular orbits of increasing radii, presents a certain width, and each tower is separated from the preceding by a certain distance. This distance can be reduced to the point where the beam constitutes a kind of continuous web in the median plane of the cyclotron.
- a fraction of the beam or ply, located radially outward then strikes the target, while the fraction of the beam or the ply located radially inward continues its course in the machine. This technique is used widely and successfully in the case of solid targets.
- WO2013049809 discloses a target set for producing radioisotopes for the synthesis of products
- a thin cover sheet 14 made of a beam permeable material covers the chamber and is secured to the container so as to seal the chamber by means of a front clamp 16 and a rear clamp 18.
- a channel 24 allows access to the chamber 12 for filling or emptying the precursor material.
- Other modes of joining can be envisaged, such as welding or brazing.
- the center of the cyclotron is represented by the point O, and the arrow A represents a beam of particles traveling through a tower or an orbit with a radius less than the radial position of the target.
- Zeisler et al. (Applied Radiation and Isotopes, Vol 53, 2000, pp. 449-453) constructed a Niobium spherical target in which the particle beam strikes a first window made of 0.3 mm thick aluminum foil, then a sheet of water
- the container of this target has no thin window for beam penetration.
- the container must on the one hand resist
- the spherical shape chosen is the one that gives the best resistance to pressure, the stresses being distributed in a uniform.
- the thickness required to allow forming and welding of the two hemispheres and the two tubes results in the beam losing a significant portion of its energy during the crossing, which generates heat, and requires additional cooling. the beam penetration zone.
- This additional cooling is achieved by a circulation of water, which requires the aluminum window and the sheet of water, which in turn causes a loss of energy and a production of heat. Due to the need for this additional cooling, this target is not suitable for use as an internal target. This target requires a relatively high proton energy (19 MeV) to allow a significant production of 18 F because the energy loss of these protons in the cooling system and the container wall is about 8 MeV.
- An object of the invention is to provide a container for use in the production of radioisotopes, a method for obtaining such a container, and a set of target comprising such a container, which is reliable, easy to to assemble and use, and which has a very good transparency to the particle beam.
- the invention is defined by the independent claims. The dependent claims define preferred embodiments of the invention.
- the container for the production of radioisotopes by irradiation of a precursor material.
- the container consists of a metal casing in one piece, the wall of said casing having a thin fraction, of a thickness of between 5 and 100 ⁇ m, the balance having a thickness greater than 100 ⁇ . .
- said envelope has a symmetry of revolution, said thin fraction extending over a fraction of the height of the envelope.
- the container may comprise at least one end
- An end of said envelope can be closed.
- the thin fraction may have an outer diameter of between 4 mm and 100 mm.
- the container may consist, at least in part, of at least one of the metals selected from nickel, titanium, niobium, tantalum and stainless steels. Alloys such as Havar®, Invar® and Kovar® are also preferred. Alloys having a low coefficient of thermal expansion are advantageous in the case of rotating targets.
- a method for obtaining a container according to the invention which comprises the steps of:
- a set of target for the production of radioisotopes comprising a container according to the invention, and comprising a support tube comprising at one end a threaded portion, and a ring having a suitable internal thread, the support tube and the ring being configured to grip the container.
- the support tube can then advantageously have a conical end congruent to the end of the container, and the ring have a conical end congruent to the end of the container.
- the tube of The carrier and the container are rotatably mounted about an axis and the target assembly includes a motor arranged to rotate the support tube and the container.
- the target assembly may comprise a cooling tube disposed inside the container, arranged to allow the circulation of a cooling liquid.
- the cooling tube may comprise, at its lower end, a cooling head, which may have on a portion of its periphery capable of receiving the beam, a recess, which gives the incident beam a longer path. important in a precursor liquid.
- the target set according to the invention can be used as an internal target for a cyclotron or as an external target. It can also be used as a beam stop.
- FIG. 1 is a sectional view of a container of the prior art, namely that of WO2013049809.
- FIG. 2 is a perspective view of a container according to the invention.
- FIG. 3 is an exploded view and perspective view of the lower portion of a target assembly according to the invention.
- FIG. 4 is a sectional view of the lower part of a target assembly according to the invention.
- FIG. 5 is an axial sectional view in perspective of the upper part of a target assembly according to the invention, in one embodiment for rotating the container.
- Figs. 6a, 6b and 6c are a sectional view and a perspective view, a sectional view, and a detailed view, respectively, of a cyclotron in which a target assembly according to the invention, with possibility of rotation, is arranged as an internal target.
- FIG. 7a is a perspective view of the lower end of a cooling tube of a thimble according to a method particular embodiment of the invention.
- Fig. 7b is a top view of a section perpendicular to the axis of this tube in position in a container.
- FIG. 8 shows sectional views of a plurality of embodiments of containers according to the invention and a cavalier perspective view of one of them.
- FIG. 1 is a sectional view of a container of the prior art, namely that of WO2013049809 and has been described above.
- FIG. 2 is a perspective view of a container 100 according to the invention.
- This container 100 is in the form of a "thimble" having a symmetry of revolution about an axis.
- the upper part 1 10 is open and may have a conical shape, the opening of the cone being oriented upwards. As explained below, this arrangement is of interest for assembling the container 100 in a target set.
- a first cylindrical portion 120 is connected upwardly to the upper portion 1 and downwardly to a thin-walled portion 130.
- This thin-walled portion 130 is connected to a second cylindrical portion 140, which in turn connects to a dome 150 closing the container 100 from below.
- the thickness of the thin fraction is less than or equal to 100 ⁇ , for example 80, 60, 40.20, 10 or even 5 ⁇ .
- cylindrical and cupola 150 are made in a thickness greater than the thickness of the thin wall fraction 130.
- the non-thinned portions may have a thickness greater than or equal to 100 ⁇ , for example 200 ⁇ or more.
- the various parts of the container 100 are connected to each other without sharp angles, so that a better mechanical resistance, especially at the pressure, is obtained.
- the inside diameter may be of the order of 10 mm, the total height of 1 1 mm, the angle of the cone may be 30 °.
- the container 100 has been shown in cylindrical form.
- a container 100 having a more complex shape with an inward curvature, such as a hyperboloid to a web, or a swollen shape, such as a barrel.
- the container 100 has been shown with an opening up and a closed side down.
- a container 100 having two openings as shown.
- the Applicant has developed a manufacturing method by which the shape shown or other forms can be easily achieved. This process is based on electroforming:
- This matrix may be made for example of aluminum
- Electrodeposition depositing a metal layer on the entire outer surface of the matrix, until the desired thickness for the thin part;
- a fraction of the height of the matrix is masked by application of an insulating layer, for example a varnish or a plastic tape;
- Electrodeposition is continued until the desired thickness is obtained for the non-thinned portions;
- the matrix is removed, for example in a caustic solution.
- the thickness of the deposit is determined by the intensity of the current and the duration of its application.
- the following metals can be used: nickel, titanium, niobium, tantalum and alloys can also be obtained such as stainless steel, Havar® (cobalt-based alloy), Invar® or Kovar® .
- the point of Beam penetration into the container constitutes a hot spot, which moves continuously. This point is a source of dilations / contractions
- a low coefficient of expansion material such as Invar® and Kovar®
- Different metals or alloys can also be deposited during successive electrodeposition steps, so as to obtain a first layer in a material, and one or more other layers in other materials. We can choose the material
- Niobium can advantageously be used for the first layer, forming the inner wall of the container, which is in contact with the precursor material. Indeed, it is known that the use of niobium does not lead to the contamination of the radioisotope produced by unwanted radioisotopes.
- the choice of the thickness of the thin portion 130 is an important element of the invention.
- the residual energy of a proton beam having an energy of 7, 10, 15, 20, and 30 MeV after passing through a nickel sheet of various thicknesses has been indicated. It can be seen that when the sheet has a thickness of 5 ⁇ , the energy loss of the protons is negligible, namely, 3% at 7 MeV, and less than 0.2% at 30 MeV. On the other hand, at 100 ⁇ , and low energy, the loss in the sheet is substantial. It is then necessary to use a higher energy accelerator and therefore more expensive. It is known that the production yield of 18 F from H 2 18 O by reaction (p, n) is practically zero when the protons have an energy less than 3 MeV. To obtain a yield higher than 60mCi ⁇ A, it is necessary to use protons of at least 6 MeV.
- the thickness values shown in bold in the table below are therefore the preferred maximum thicknesses, depending on the energy of the available beam. If you want a
- the choice of a thinner wall limits the production of heat during the beam crossing.
- the table above guides the choice of thickness when the chosen material is nickel.
- Other metals such as niobium, titanium, or Havar®, have a slightly greater transparency and will give better results.
- FIG. 3 is an exploded view and perspective view of the lower portion of a target assembly according to the invention and shows how the container 100 is arranged to a support tube 200.
- the tube has a male threaded portion 220.
- a ring 300 has a corresponding female threaded portion 310.
- the ring covers the upper portion 1 10 of the container 100 and apply against the lower portion of the support tube 200. At least the thin wall portion 130 of the container 100 emerges from the together so formed.
- the support tube 200 and the ring 300 may comprise flats 210, 320 which then allow an operator to assemble and disassemble the assembly very quickly by means of two flat keys.
- the support tube 200 and the ring 300 may be made for example of stainless steel. Other ways
- the lower part of the support tube 200 has a conical end 230 congruent with the conical portion 1 10 of the container 100, itself congruent a conical end 330 of the ring 300.
- an excellent seal can be obtained without having to resort to a seal: sealing is ensured by the metal-on-metal contact.
- FIG. 4 is a sectional view of the lower part of a target assembly according to the invention.
- the assembly "glove finger” 400 which has the dual function of cooling the precursor material contained in the container and which in turn cools the container, and to allow the loading or unloading of the precursor material in the container.
- a cooling tube 410 closed at its lower end can be inserted into the support tube 200 and end up in the container 100.
- the container 1 00 has an internal diameter of 10 mm, and a height of 10 mm.
- the cooling tube 410 has an outer diameter of 8 mm, the irradiation chamber 440 having a working volume of approximately 350 mm 3 .
- An intermediate tube 420 open at its lower end 425, and of smaller diameter than that of the cooling tube is inserted therein. It is thus possible to circulate a cooling liquid such as water in the space between this cooling tube 410 and this inner tube 420.
- the arrows A represent the coolant inlet and the arrows B the exit of cooling liquid. Circulation directions A and B can be reversed.
- the heat exchange surface being large and evenly distributed, this arrangement allows excellent cooling.
- the assembly "glove finger" 400 remains fixed. The relative movement of these two sets produces a stirring which further improves the cooling, inducing a forced convection.
- a capillary tube 430 placed axially inside the intermediate tube 420, and sealingly crossing the lower end of the cooling tube 410 to end in the space between the container 100 and the cooling tube 410 allows the loading and unloading the precursor material as indicated by the bidirectional arrow C. It is shown in enlarged view how the conical portion 1 10 of the container is clamped between the conical end of the ring 330 and the conical end of the support tube 230 , thus ensuring the seal without the use of a seal.
- the target set of the invention is used as an internal target or as an external target, it is advantageous to be able to rotate it. It can be given successively different orientations, for example, a rotation of 10 ° for each use, or preferably, ensure a continuous rotation of the container 100 during the irradiation. It is thus possible to ensure that the entire periphery of the thin wall fraction is traversed by the beam, which ensures a better distribution of heat production over a larger area.
- the rotation induces stirring of the precursor material, which improves the convection cooling.
- Fig. 5 is an axial and perspective sectional view of the upper portion 500 of a target assembly according to the invention, in one embodiment
- the container 100 (not shown in the figure) and the support tube 200 are arranged in the rotor 570 of an electric motor.
- the stator 560 is secured to a support case 510 which is fixed. Maintaining and sealing are provided by a bearing-seal having a fixed portion 540 and a rotating portion 542.
- This bearing-seal may include ball bearings 550 and 550 '.
- This seal may be for example a ferrofluidic joint such as those provided by Rigaku.
- the dispensing head of the thermowell 400 emerges at the top of the target assembly and provides access to the inlet or outlet ports 452, 454 for cooling liquid and 430 filling / emptying of the precursor material. There may be two tubes for separate input and output.
- FIG. 6a and 6b There is shown in Figures 6a and 6b a cyclotron 700 in which a set of target according to the invention is disposed.
- the upper part 500 emerges from the upper face of the cyclotron 700.
- the support tube 200 has a length such that the container 701 is in the median plane of the cyclotron, the thin fraction of which is exposed to the beam, as shown in detail view 6c.
- the target assembly of the invention When the target assembly of the invention is used as an external target, it can be arranged at the end of the beam line, and receive it radially. It is also possible to make a container whose thin part is located on the base like the containers 907 and 909 shown in Fig.9 and to orient the beam towards this base, parallel to the axis of symmetry of the container.
- radioisotope precursors such as H 2 18 O
- H 2 18 O Some radioisotope precursors, such as H 2 18 O, are valuable and expensive. Moreover, it is sometimes advantageous to be able to synthesize radiochemically from a concentrated product. It is therefore
- FIG. 7a is a perspective view of the lower end of a cooling head 800 of a thimble of this preferred mode.
- This tube has a face 801 having an optimized profile as discussed below.
- the coolant inlet / outlet ports 802 make it possible to circulate the coolant inside the cooling head 800.
- the inlet / outlet ports of the precursor liquid 803 open below the lower end of the cooling head 800 and provide access to the space between the container and the cooling head 800.
- Fig. 7b is a top view of a section perpendicular to the axis of this cooling head 800 in position in a container 860.
- the cooling head 800 has a part of its periphery, a recess 851, which gives the incident beam, represented by the arrows F, a greater path 852 in the precursor liquid, while the space between the cooling head 800 and the container 860 is smaller where there is no incident beam. The length of this path is determined so that the beam can deposit all its useful energy in the precursor material.
- Thermocouples 805 provide real-time temperature control of the target.
- the container 860 is rotated, while the cooling head 800 is fixed, which promotes the mixing of the precursor liquid, and the exchange
- the inside diameter of the container 860 is 10 mm
- the outside diameter of the cooling head is 9.5 mm
- the useful volume of the chamber is 100 mm 3 .
- FIG. 9 shows sectional views of a plurality of embodiments of containers according to the invention.
- the arrow X represents the direction of the incident beam.
- the X arrow also indicates the position of the thin wall.
- the cuts are limited to the facial section of the solids so as to facilitate the representation of the thin walls.
- the container 901 symmetrical of revolution, cylindrical, and conical top end, is one of the preferred embodiments of the invention.
- the container 902, symmetrical of revolution, has two open ends, both of conical shape.
- the containers 903 and 904 are similar to the container 901, except they have an open end with a flat edge and an open end with a cylindrical edge, respectively.
- the container 905 is similar to the container 901, except that it has a shape of "barrel"
- the container 906 is similar to the container 901, except that it has a hyperboloid shape to a web.
- the container 907 is similar to the container 901, except that it has a thin wall on the closed end. It thus allows axial penetration of the beam.
- the container 908 unlike the other containers shown, has no symmetry of revolution, but a square or rectangular section, the thin wall may extend over a portion of two or three faces. This container is also represented in a cavalier perspective.
- the container 910 is similar to the container 901, except that it has a larger diameter, for example 50 mm, and a flat bottom.
- the container 909 is similar to the container 910, except that the thin portion is arranged in a ring on the flat bottom and allows axial penetration of the beam.
- This container can advantageously be used in an external target, in which the incident beam is parallel to the axis of rotation, as represented by the arrow X.
- the targets 901 to 907 can be arranged in such a way that the beam penetrates radially into the target.
- the container 100 according to the invention has the advantage of being in one piece, that is to say not requiring assembly means, or assembly work or disassembly.
- the thin fraction 130 of the container 100 constitutes, as it were, a window integrated in the container 100.
- the target and the container 100 according to the invention allow easy disassembly and reassembly. The operator can act quickly and can therefore limit his exposure to radiation.
- the container of the invention requires little material. It is therefore inexpensive and has little waste when it needs to be disposed of.
- the target assembly according to the invention may incidentally serve as a beam stop, for example during the development of an accelerator.
- the invention can be applied to other liquid precursors, such as than the ordinary water H 2 16 0 which produces 13 N during irradiation with protons, or gaseous such as 14 N 2 , to obtain 11 C.
- the invention can also be applied to powdery precursor materials. or powders suspended in a liquid and forming sludge.
- the invention also applies to the case of a precursor material such as 11 B 2 O 3 , which produces 11 C by reaction (p, n) and form of 11 CO 2 that can be collected.
- Other particles can be used, such as deuterons and alpha particles.
- the target according to the invention can be used, the chamber of the container being at atmospheric pressure, or the chamber being kept under pressure.
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- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- High Energy & Nuclear Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Spectroscopy & Molecular Physics (AREA)
- General Chemical & Material Sciences (AREA)
- Optics & Photonics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Electrochemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Particle Accelerators (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE2014/0551A BE1023217B1 (fr) | 2014-07-10 | 2014-07-10 | Conteneur, son procede d'obtention, et ensemble de cible pour la production de radio-isotopes utilisant un tel conteneur |
PCT/EP2015/065687 WO2016005492A1 (fr) | 2014-07-10 | 2015-07-09 | Conteneur, son procédé d'obtention, et ensemble de cible pour la production de radio-isotopes utilisant un tel conteneur |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3167456A1 true EP3167456A1 (fr) | 2017-05-17 |
EP3167456B1 EP3167456B1 (fr) | 2018-04-18 |
Family
ID=51609855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP15736824.2A Active EP3167456B1 (fr) | 2014-07-10 | 2015-07-09 | Conteneur, son procédé d'obtention, et ensemble de cible pour la production de radio-isotopes utilisant un tel conteneur |
Country Status (6)
Country | Link |
---|---|
US (1) | US10854349B2 (fr) |
EP (1) | EP3167456B1 (fr) |
CN (1) | CN106716548B (fr) |
BE (1) | BE1023217B1 (fr) |
CA (1) | CA2957639C (fr) |
WO (1) | WO2016005492A1 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE1023217B1 (fr) | 2014-07-10 | 2016-12-22 | Pac Sprl | Conteneur, son procede d'obtention, et ensemble de cible pour la production de radio-isotopes utilisant un tel conteneur |
US9961756B2 (en) * | 2014-10-07 | 2018-05-01 | General Electric Company | Isotope production target chamber including a cavity formed from a single sheet of metal foil |
US10354771B2 (en) | 2016-11-10 | 2019-07-16 | General Electric Company | Isotope production system having a target assembly with a graphene target sheet |
US11443868B2 (en) * | 2017-09-14 | 2022-09-13 | Uchicago Argonne, Llc | Triple containment targets for particle irradiation |
US11315700B2 (en) * | 2019-05-09 | 2022-04-26 | Strangis Radiopharmacy Consulting and Technology | Method and apparatus for production of radiometals and other radioisotopes using a particle accelerator |
CZ309802B6 (cs) * | 2021-04-16 | 2023-10-25 | Extreme Light Infrastructure ERIC (ELI ERIC) | Jaderný terčík, způsob indukce jaderné reakce s tímto jaderným terčíkem a zařízení na výrobu radioizotopů s tímto jaderným terčíkem |
Family Cites Families (12)
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US3971697A (en) * | 1972-04-25 | 1976-07-27 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Production of 123 I |
US3940617A (en) * | 1975-04-07 | 1976-02-24 | The United States Of America As Represented By The United States Energy Research And Development Administration | Method for nondestructive fuel assay of laser fusion targets |
US6011825A (en) * | 1995-08-09 | 2000-01-04 | Washington University | Production of 64 Cu and other radionuclides using a charged-particle accelerator |
US5713828A (en) * | 1995-11-27 | 1998-02-03 | International Brachytherapy S.A | Hollow-tube brachytherapy device |
EP1429345A1 (fr) * | 2002-12-10 | 2004-06-16 | Ion Beam Applications S.A. | Dispositif et procédé de production de radio-isotopes |
US7831009B2 (en) * | 2003-09-25 | 2010-11-09 | Siemens Medical Solutions Usa, Inc. | Tantalum water target body for production of radioisotopes |
JP2008525968A (ja) * | 2004-12-22 | 2008-07-17 | フォックス・チェイス・キャンサー・センター | レーザ加速された陽子線治療器およびその超電導電磁石システム |
US8526561B2 (en) * | 2008-07-30 | 2013-09-03 | Uchicago Argonne, Llc | Methods for making and processing metal targets for producing Cu-67 radioisotope for medical applications |
KR100982302B1 (ko) * | 2008-12-26 | 2010-09-15 | 한전원자력연료 주식회사 | 연료봉 들림 방지 미늘을 가진 이물질여과용 하부지지격자 |
US20100226472A1 (en) * | 2009-03-06 | 2010-09-09 | Westinghouse Electric Company Llc | Nuclear fuel element and assembly |
AU2011282744B2 (en) * | 2010-07-29 | 2014-11-06 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Isotope production target |
BE1023217B1 (fr) | 2014-07-10 | 2016-12-22 | Pac Sprl | Conteneur, son procede d'obtention, et ensemble de cible pour la production de radio-isotopes utilisant un tel conteneur |
-
2014
- 2014-07-10 BE BE2014/0551A patent/BE1023217B1/fr not_active IP Right Cessation
-
2015
- 2015-07-09 US US15/325,014 patent/US10854349B2/en active Active
- 2015-07-09 EP EP15736824.2A patent/EP3167456B1/fr active Active
- 2015-07-09 WO PCT/EP2015/065687 patent/WO2016005492A1/fr active Application Filing
- 2015-07-09 CA CA2957639A patent/CA2957639C/fr active Active
- 2015-07-09 CN CN201580046840.4A patent/CN106716548B/zh active Active
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Publication number | Publication date |
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CA2957639C (fr) | 2023-02-21 |
WO2016005492A1 (fr) | 2016-01-14 |
CA2957639A1 (fr) | 2016-01-14 |
US10854349B2 (en) | 2020-12-01 |
BE1023217B1 (fr) | 2016-12-22 |
CN106716548A (zh) | 2017-05-24 |
EP3167456B1 (fr) | 2018-04-18 |
CN106716548B (zh) | 2019-03-15 |
US20170213614A1 (en) | 2017-07-27 |
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