EP3146076A4 - Profils d'expression génique associés au rejet de greffe du rein subclinique - Google Patents

Profils d'expression génique associés au rejet de greffe du rein subclinique Download PDF

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Publication number
EP3146076A4
EP3146076A4 EP15795439.7A EP15795439A EP3146076A4 EP 3146076 A4 EP3146076 A4 EP 3146076A4 EP 15795439 A EP15795439 A EP 15795439A EP 3146076 A4 EP3146076 A4 EP 3146076A4
Authority
EP
European Patent Office
Prior art keywords
sub
gene expression
transplant rejection
expression profiles
profiles associated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP15795439.7A
Other languages
German (de)
English (en)
Other versions
EP3146076A2 (fr
Inventor
Daniel Salomon
John FRIEDEWALD
Sunil KURIAN
Michael Abecassis
Steven Head
Phillip Todd ORDOUKHANIAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Northwestern University
Original Assignee
Scripps Research Institute
Northwestern University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP14841998.9A external-priority patent/EP3044333A4/fr
Application filed by Scripps Research Institute, Northwestern University filed Critical Scripps Research Institute
Priority to EP20193092.2A priority Critical patent/EP3825416A3/fr
Publication of EP3146076A2 publication Critical patent/EP3146076A2/fr
Publication of EP3146076A4 publication Critical patent/EP3146076A4/fr
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP15795439.7A 2014-05-22 2015-05-22 Profils d'expression génique associés au rejet de greffe du rein subclinique Ceased EP3146076A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20193092.2A EP3825416A3 (fr) 2014-05-22 2015-05-22 Profils d'expression génique associés au rejet de greffe du rein subclinique

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462001889P 2014-05-22 2014-05-22
US201462001909P 2014-05-22 2014-05-22
US201462001902P 2014-05-22 2014-05-22
US201462029038P 2014-07-25 2014-07-25
EP14841998.9A EP3044333A4 (fr) 2013-09-09 2014-09-09 Méthodes et systèmes permettant l'analyse d'une transplantation d'organes
US14/481,167 US20150167085A1 (en) 2013-09-09 2014-09-09 Methods and Systems for Analysis of Organ Transplantation
PCT/US2015/032202 WO2015179777A2 (fr) 2014-05-22 2015-05-22 Profils d'expression génique associés au rejet de greffe du rein subclinique

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP20193092.2A Division EP3825416A3 (fr) 2014-05-22 2015-05-22 Profils d'expression génique associés au rejet de greffe du rein subclinique

Publications (2)

Publication Number Publication Date
EP3146076A2 EP3146076A2 (fr) 2017-03-29
EP3146076A4 true EP3146076A4 (fr) 2018-05-09

Family

ID=60514903

Family Applications (2)

Application Number Title Priority Date Filing Date
EP20193092.2A Pending EP3825416A3 (fr) 2014-05-22 2015-05-22 Profils d'expression génique associés au rejet de greffe du rein subclinique
EP15795439.7A Ceased EP3146076A4 (fr) 2014-05-22 2015-05-22 Profils d'expression génique associés au rejet de greffe du rein subclinique

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP20193092.2A Pending EP3825416A3 (fr) 2014-05-22 2015-05-22 Profils d'expression génique associés au rejet de greffe du rein subclinique

Country Status (2)

Country Link
EP (2) EP3825416A3 (fr)
WO (1) WO2015179777A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
WO2019217910A1 (fr) * 2018-05-10 2019-11-14 The Scripps Research Institute Classificateurs à l'échelle du génome pour détecter un rejet de greffe subaigu et d'autres conditions de transplantation
KR101965411B1 (ko) * 2018-08-07 2019-04-03 경북대학교 산학협력단 신장이식 거부반응 진단용 조성물과 진단 마커 검출 방법
WO2020148358A1 (fr) 2019-01-17 2020-07-23 Katholieke Universiteit Leuven Biomarqueurs à base d'arnm pour rejet de greffe à médiation par anticorps
CA3220486A1 (fr) 2021-05-28 2022-12-01 Centre Hospitalier Universitaire De Nantes Diagnostic non invasif de rejet subclinique
CN113447648B (zh) * 2021-07-01 2022-04-19 浙江大学 检测抗富含丝氨酸/精氨酸剪接因子9-IgG抗体的试剂盒

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WO2009045104A1 (fr) * 2007-10-05 2009-04-09 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Procédé de diagnostic d'un rejet présymptomatique de greffe d'organes

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US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
CA2072758A1 (fr) 1990-09-14 1992-03-15 Kenneth Francis Buechler Anticorps liant aux complexes de recepteurs de ligands et de ligands et leur utilite dans les tests ligand-recepteur
EP0585310B1 (fr) 1991-04-10 1999-03-17 Biosite Diagnostics Inc. Inhibiteurs de "liaison croisee" et leurs utilisations
ES2150915T3 (es) 1991-04-12 2000-12-16 Biosite Diagnostics Inc Nuevos conjugados y dosificados destinados para la deteccion simultanea de ligandos multiples.
US5458852A (en) 1992-05-21 1995-10-17 Biosite Diagnostics, Inc. Diagnostic devices for the controlled movement of reagents without membranes
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US5824799A (en) 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
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Non-Patent Citations (9)

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Title
DIRK R. J. KUYPERS: "Immunosuppressive Drug Therapy and Subclinical Acute Renal Allograft Rejection: Impact and Effect :", TRANSPLANTATION, vol. 85, no. Supplement, April 2008 (2008-04-01), GB, pages S25 - S30, XP055433194, ISSN: 0041-1337, DOI: 10.1097/TP.0b013e318169c48d *
ESTHER CRISTINA AQUINO DIAS ET AL: "Molecular markers in subclinical acute rejection of renal transplants", CLINICAL TRANSPLANTATION., vol. 18, no. 3, June 2004 (2004-06-01), DK, pages 281 - 287, XP055432395, ISSN: 0902-0063, DOI: 10.1111/j.1399-0012.2004.00161.x *
FRANCISCO V VERONESE ET AL: "Prevalence and immunohistochemical findings of subclinical kidney allograft rejection and its association with graft outcome", CLINICAL TRANSPLANTATION., vol. 18, no. 4, August 2004 (2004-08-01), DK, pages 357 - 364, XP055432637, ISSN: 0902-0063, DOI: 10.1111/j.1399-0012.2004.00170.x *
M L LIPMAN ET AL: "Immune-activation gene expression in clinically stable renal allograft biopsies: molecular evidence for subclinical rejection.", TRANSPLANTATION, vol. 66, no. 12, 27 December 1998 (1998-12-27), pages 1673 - 1681, XP055432485 *
NOORA ALAKULPPI ET AL: "Feasibility of Diagnosing Subclinical Renal Allograft Rejection in Children By Whole Blood Gene Expression Analysis :", TRANSPLANTATION, vol. 86, no. 9, November 2008 (2008-11-01), GB, pages 1222 - 1228, XP055433160, ISSN: 0041-1337, DOI: 10.1097/TP.0b013e3181883fb0 *
PENG W ET AL: "Prediction of subclinical renal allograft rejection by vascular endothelial growth factor in serum and urine", JOURNAL OF NEPHROLOGY, SPRINGER, WICHTIG, IT, vol. 21, no. 4, July 2008 (2008-07-01), pages 535 - 542, XP008152271, ISSN: 1121-8428 *
S. M. KURIAN ET AL: "Orthogonal Comparison of Molecular Signatures of Kidney Transplants With Subclinical and Clinical Acute Rejection: Equivalent Performance Is Agnostic to Both Technology and Platform", AMERICAN JOURNAL OF TRANSPLANTATION, vol. 17, no. 8, August 2017 (2017-08-01), DK, pages 2103 - 2116, XP055432270, ISSN: 1600-6135, DOI: 10.1111/ajt.14224 *
SILKE ROEDDER ET AL: "The kSORT Assay to Detect Renal Transplant Patients at High Risk for Acute Rejection: Results of the Multicenter AART Study", PLOS MEDICINE, vol. 11, no. 11, 11 November 2014 (2014-11-11), pages e1001759, XP055433213, DOI: 10.1371/journal.pmed.1001759 *
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Also Published As

Publication number Publication date
EP3825416A2 (fr) 2021-05-26
EP3146076A2 (fr) 2017-03-29
EP3825416A3 (fr) 2021-09-15
WO2015179777A2 (fr) 2015-11-26
WO2015179777A3 (fr) 2016-04-07

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