EP3146076A4 - Gene expression profiles associated with sub-clinical kidney transplant rejection - Google Patents

Gene expression profiles associated with sub-clinical kidney transplant rejection Download PDF

Info

Publication number
EP3146076A4
EP3146076A4 EP15795439.7A EP15795439A EP3146076A4 EP 3146076 A4 EP3146076 A4 EP 3146076A4 EP 15795439 A EP15795439 A EP 15795439A EP 3146076 A4 EP3146076 A4 EP 3146076A4
Authority
EP
European Patent Office
Prior art keywords
sub
gene expression
transplant rejection
expression profiles
profiles associated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP15795439.7A
Other languages
German (de)
French (fr)
Other versions
EP3146076A2 (en
Inventor
Daniel Salomon
John FRIEDEWALD
Sunil KURIAN
Michael Abecassis
Steven Head
Phillip Todd ORDOUKHANIAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Northwestern University
Original Assignee
Scripps Research Institute
Northwestern University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP14841998.9A external-priority patent/EP3044333A4/en
Application filed by Scripps Research Institute, Northwestern University filed Critical Scripps Research Institute
Priority to EP20193092.2A priority Critical patent/EP3825416A3/en
Publication of EP3146076A2 publication Critical patent/EP3146076A2/en
Publication of EP3146076A4 publication Critical patent/EP3146076A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP15795439.7A 2014-05-22 2015-05-22 Gene expression profiles associated with sub-clinical kidney transplant rejection Ceased EP3146076A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20193092.2A EP3825416A3 (en) 2014-05-22 2015-05-22 Gene expression profiles associated with sub-clinical kidney transplant rejection

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462001909P 2014-05-22 2014-05-22
US201462001889P 2014-05-22 2014-05-22
US201462001902P 2014-05-22 2014-05-22
US201462029038P 2014-07-25 2014-07-25
EP14841998.9A EP3044333A4 (en) 2013-09-09 2014-09-09 Methods and systems for analysis of organ transplantation
US14/481,167 US20150167085A1 (en) 2013-09-09 2014-09-09 Methods and Systems for Analysis of Organ Transplantation
PCT/US2015/032202 WO2015179777A2 (en) 2014-05-22 2015-05-22 Gene expression profiles associated with sub-clinical kidney transplant rejection

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP20193092.2A Division EP3825416A3 (en) 2014-05-22 2015-05-22 Gene expression profiles associated with sub-clinical kidney transplant rejection

Publications (2)

Publication Number Publication Date
EP3146076A2 EP3146076A2 (en) 2017-03-29
EP3146076A4 true EP3146076A4 (en) 2018-05-09

Family

ID=60514903

Family Applications (2)

Application Number Title Priority Date Filing Date
EP15795439.7A Ceased EP3146076A4 (en) 2014-05-22 2015-05-22 Gene expression profiles associated with sub-clinical kidney transplant rejection
EP20193092.2A Pending EP3825416A3 (en) 2014-05-22 2015-05-22 Gene expression profiles associated with sub-clinical kidney transplant rejection

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP20193092.2A Pending EP3825416A3 (en) 2014-05-22 2015-05-22 Gene expression profiles associated with sub-clinical kidney transplant rejection

Country Status (2)

Country Link
EP (2) EP3146076A4 (en)
WO (1) WO2015179777A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
CA3100002A1 (en) * 2018-05-10 2019-11-14 The Scripps Research Institute Genome-wide classifiers for detection of subacute transplant rejection and other transplant conditions
KR101965411B1 (en) * 2018-08-07 2019-04-03 경북대학교 산학협력단 Composition for diagnosing kidney allograft refection and method for detecting a diagnostic marker
US20220081715A1 (en) 2019-01-17 2022-03-17 Katholieke Universiteit Leuven mRNA-BASED BIOMARKERS FOR ANTIBODY-MEDIATED TRANSPLANT REJECTION
WO2022248573A2 (en) 2021-05-28 2022-12-01 Centre Hospitalier Universitaire De Nantes Non-invasive diagnosis of subclinical rejection
CN114895024A (en) * 2021-07-01 2022-08-12 浙江大学 Kit for detecting anti-serine/arginine-rich splicing factor 9-IgG antibody

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009045104A1 (en) * 2007-10-05 2009-04-09 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Method for diagnosing presymptomatic organ transplant rejection

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939272A (en) 1989-01-10 1999-08-17 Biosite Diagnostics Incorporated Non-competitive threshold ligand-receptor assays
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
CA2072758A1 (en) 1990-09-14 1992-03-15 Kenneth Francis Buechler Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays
CA2107899A1 (en) 1991-04-10 1992-10-11 Gunars Edwin Valkirs Novel conjugates and assays for simultaneous detection of multiple ligands
CA2107894C (en) 1991-04-10 2003-10-14 Kenneth F. Buechler Crosstalk inhibitors and their uses
US5458852A (en) 1992-05-21 1995-10-17 Biosite Diagnostics, Inc. Diagnostic devices for the controlled movement of reagents without membranes
US6143576A (en) 1992-05-21 2000-11-07 Biosite Diagnostics, Inc. Non-porous diagnostic devices for the controlled movement of reagents
US6019944A (en) 1992-05-21 2000-02-01 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5824799A (en) 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
WO1997027317A1 (en) 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
US6113855A (en) 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
US5947124A (en) 1997-03-11 1999-09-07 Biosite Diagnostics Incorporated Diagnostic for determining the time of a heart attack
US5863736A (en) 1997-05-23 1999-01-26 Becton, Dickinson And Company Method, apparatus and computer program products for determining quantities of nucleic acid sequences in samples
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US20040126767A1 (en) 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
DE10238922A1 (en) * 2002-08-22 2004-03-04 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Immune markers for diagnosis and therapy in connection with graft reactions
CA2511501A1 (en) 2002-12-24 2004-07-15 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
GB0419728D0 (en) * 2004-09-06 2004-10-06 Novartis Ag Organic compounds
GB0605217D0 (en) 2006-03-15 2006-04-26 Novartis Ag Method and compositions for assessing acute rejection
GB0607943D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Biomarkers for chronic transplant dysfunction
CA2666507A1 (en) 2006-10-16 2008-04-24 The Arizona Board Of Regents, A Body Corporate Of The State Of Arizona A Cting For And On Behalf Of Arizona State University Synthetic antibodies
ES2379673T3 (en) 2007-11-08 2012-04-30 Novartis Ag Gene expression signatures for chronic / sclerosing aloingert nephropathy
EP2131200A1 (en) * 2008-06-04 2009-12-09 BRAHMS Aktiengesellschaft A marker for graft failure and mortality

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009045104A1 (en) * 2007-10-05 2009-04-09 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Method for diagnosing presymptomatic organ transplant rejection

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DIRK R. J. KUYPERS: "Immunosuppressive Drug Therapy and Subclinical Acute Renal Allograft Rejection: Impact and Effect :", TRANSPLANTATION, vol. 85, no. Supplement, April 2008 (2008-04-01), GB, pages S25 - S30, XP055433194, ISSN: 0041-1337, DOI: 10.1097/TP.0b013e318169c48d *
ESTHER CRISTINA AQUINO DIAS ET AL: "Molecular markers in subclinical acute rejection of renal transplants", CLINICAL TRANSPLANTATION., vol. 18, no. 3, June 2004 (2004-06-01), DK, pages 281 - 287, XP055432395, ISSN: 0902-0063, DOI: 10.1111/j.1399-0012.2004.00161.x *
FRANCISCO V VERONESE ET AL: "Prevalence and immunohistochemical findings of subclinical kidney allograft rejection and its association with graft outcome", CLINICAL TRANSPLANTATION., vol. 18, no. 4, August 2004 (2004-08-01), DK, pages 357 - 364, XP055432637, ISSN: 0902-0063, DOI: 10.1111/j.1399-0012.2004.00170.x *
M L LIPMAN ET AL: "Immune-activation gene expression in clinically stable renal allograft biopsies: molecular evidence for subclinical rejection.", TRANSPLANTATION, vol. 66, no. 12, 27 December 1998 (1998-12-27), pages 1673 - 1681, XP055432485 *
NOORA ALAKULPPI ET AL: "Feasibility of Diagnosing Subclinical Renal Allograft Rejection in Children By Whole Blood Gene Expression Analysis :", TRANSPLANTATION, vol. 86, no. 9, November 2008 (2008-11-01), GB, pages 1222 - 1228, XP055433160, ISSN: 0041-1337, DOI: 10.1097/TP.0b013e3181883fb0 *
PENG W ET AL: "Prediction of subclinical renal allograft rejection by vascular endothelial growth factor in serum and urine", JOURNAL OF NEPHROLOGY, SPRINGER, WICHTIG, IT, vol. 21, no. 4, July 2008 (2008-07-01), pages 535 - 542, XP008152271, ISSN: 1121-8428 *
S. M. KURIAN ET AL: "Orthogonal Comparison of Molecular Signatures of Kidney Transplants With Subclinical and Clinical Acute Rejection: Equivalent Performance Is Agnostic to Both Technology and Platform", AMERICAN JOURNAL OF TRANSPLANTATION, vol. 17, no. 8, August 2017 (2017-08-01), DK, pages 2103 - 2116, XP055432270, ISSN: 1600-6135, DOI: 10.1111/ajt.14224 *
SILKE ROEDDER ET AL: "The kSORT Assay to Detect Renal Transplant Patients at High Risk for Acute Rejection: Results of the Multicenter AART Study", PLOS MEDICINE, vol. 11, no. 11, 11 November 2014 (2014-11-11), pages e1001759, XP055433213, DOI: 10.1371/journal.pmed.1001759 *
W PENG ET AL: "Non-invasive Detection of Acute Renal Allograft Rejection by Measurement of Vascular Endothelial Growth Factor in Urine", THE JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, vol. 35, 2007, pages 442 - 449, XP055432356 *

Also Published As

Publication number Publication date
EP3146076A2 (en) 2017-03-29
WO2015179777A2 (en) 2015-11-26
EP3825416A3 (en) 2021-09-15
WO2015179777A3 (en) 2016-04-07
EP3825416A2 (en) 2021-05-26

Similar Documents

Publication Publication Date Title
IL255157A0 (en) Microfluidic cell culture
EP3411295A4 (en) Social drone
AU2015249322B2 (en) Syringe with rolling diaphragm
EP3117380A4 (en) Career analytics platform
EP3040826A4 (en) Smartphone
EP3158089A4 (en) On-slide staining by primer extension
EP3166526A4 (en) Alignment precision
EP3123431A4 (en) Multi-stage geolocated offers
EP3093363A4 (en) Bearing component
HUE051027T2 (en) Culture medium
HK1253068A1 (en) Microfluidic cell culture
EP3192946A4 (en) Inter-member connecting structure
EP3227663A4 (en) Removable optical assembly
EP3504315A4 (en) Bioreactor
EP3109313A4 (en) Culture container
EP3146076A4 (en) Gene expression profiles associated with sub-clinical kidney transplant rejection
EP3098464A4 (en) Sliding bearing
EP3259366A4 (en) Microbial microfluidic biosensor
EP3219589A4 (en) Structural member
EP3037562A4 (en) Sliding bearing
EP3209786A4 (en) Multi-stage bioreactor processes
EP3365107B8 (en) Cell culture
EP3242129A4 (en) Electrochemical biosensor
EP3098466A4 (en) Slide bearing
EP3364060A4 (en) Half bearing

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20161124

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
RIC1 Information provided on ipc code assigned before grant

Ipc: C12Q 1/68 20180101AFI20171213BHEP

Ipc: G01N 33/53 20060101ALI20171213BHEP

Ipc: G01N 33/68 20060101ALI20171213BHEP

RIC1 Information provided on ipc code assigned before grant

Ipc: C12Q 1/68 20060101AFI20180329BHEP

Ipc: G01N 33/53 20060101ALI20180329BHEP

Ipc: G01N 33/68 20060101ALI20180329BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20180409

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/53 20060101ALI20180403BHEP

Ipc: C12Q 1/68 20060101AFI20180403BHEP

Ipc: G01N 33/68 20060101ALI20180403BHEP

17Q First examination report despatched

Effective date: 20190502

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

REG Reference to a national code

Ref country code: DE

Ref legal event code: R003

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20201023