EP3126332A4 - Activateurs d'histone acétyltransférase et utilisation desdits activateurs - Google Patents
Activateurs d'histone acétyltransférase et utilisation desdits activateurs Download PDFInfo
- Publication number
- EP3126332A4 EP3126332A4 EP15774440.0A EP15774440A EP3126332A4 EP 3126332 A4 EP3126332 A4 EP 3126332A4 EP 15774440 A EP15774440 A EP 15774440A EP 3126332 A4 EP3126332 A4 EP 3126332A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- histone acetyltransferase
- activators
- acetyltransferase activators
- histone
- acetyltransferase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000003893 Histone acetyltransferases Human genes 0.000 title 1
- 108090000246 Histone acetyltransferases Proteins 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
- C07D265/22—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Oncology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18158529.0A EP3398937A1 (fr) | 2014-03-31 | 2015-03-30 | Activateurs de l'histone acétyltransférase et leurs utilisations |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461972571P | 2014-03-31 | 2014-03-31 | |
US201462023715P | 2014-07-11 | 2014-07-11 | |
PCT/US2015/023258 WO2015153410A1 (fr) | 2014-03-31 | 2015-03-30 | Activateurs d'histone acétyltransférase et utilisation desdits activateurs |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18158529.0A Division EP3398937A1 (fr) | 2014-03-31 | 2015-03-30 | Activateurs de l'histone acétyltransférase et leurs utilisations |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3126332A1 EP3126332A1 (fr) | 2017-02-08 |
EP3126332A4 true EP3126332A4 (fr) | 2017-09-06 |
Family
ID=54241152
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18158529.0A Withdrawn EP3398937A1 (fr) | 2014-03-31 | 2015-03-30 | Activateurs de l'histone acétyltransférase et leurs utilisations |
EP15774440.0A Withdrawn EP3126332A4 (fr) | 2014-03-31 | 2015-03-30 | Activateurs d'histone acétyltransférase et utilisation desdits activateurs |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP18158529.0A Withdrawn EP3398937A1 (fr) | 2014-03-31 | 2015-03-30 | Activateurs de l'histone acétyltransférase et leurs utilisations |
Country Status (9)
Country | Link |
---|---|
US (3) | US20170182054A1 (fr) |
EP (2) | EP3398937A1 (fr) |
JP (1) | JP2017511340A (fr) |
CN (1) | CN106604913A (fr) |
AU (2) | AU2015241177B2 (fr) |
BR (1) | BR112016022879A2 (fr) |
CA (1) | CA2944613A1 (fr) |
IL (1) | IL248144A0 (fr) |
WO (1) | WO2015153410A1 (fr) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2017298473A1 (en) * | 2016-07-20 | 2019-01-24 | The Trustees Of Columbia University In The City Of New York | Histone acetyltransferase activators and compositions and uses thereof |
US11274100B2 (en) | 2017-06-21 | 2022-03-15 | Daiichi Sankyo Company, Limited | EP300/CREBBP inhibitor |
AU2020219351A1 (en) * | 2019-02-08 | 2021-08-26 | Appia Pharmaceuticals, LLC | Histone acetyltransferase modulators and compositions and uses thereof |
EP3920897A4 (fr) * | 2019-02-08 | 2022-11-16 | The Trustees of Columbia University in the City of New York | Régulateurs d'histone acétyltransférase (hat) et utilisations associées |
KR20220150880A (ko) * | 2019-11-25 | 2022-11-11 | 게인 테라퓨틱스 에스에이 | 아릴 및 헤테로아릴 화합물, 및 갈락토세레브로시다제의 활성 변경과 관련된 병태에서의 치료 용도 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1124613A (en) * | 1966-01-15 | 1968-08-21 | Hoechst Ag | ª†-resorcylic acid anilides and process for preparing them |
WO2004089470A2 (fr) * | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Utilisation pharmaceutique d'amides substitues |
WO2012088420A1 (fr) * | 2010-12-22 | 2012-06-28 | The Trustees Of Columbia University In The City Of New York | Modulateurs de l'histone acétyltransférase et leurs utilisations |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0102782A3 (en) * | 1998-06-19 | 2002-12-28 | Smithkline Beecham Corp | Salycilanilide as inhibitors of transcription factor nf-kb |
EP1590318A2 (fr) * | 2002-12-12 | 2005-11-02 | Jawaharlal Nehru Centre For Advanced Scientific Research | Modulateurs (inhibiteurs/activateurs) d'histone acetyltransferases |
AU2003288705A1 (en) | 2002-12-12 | 2004-06-30 | Jawaharlal Nehru Centre For Advanced Scientific Research | Modulators (inhibitors/activators) of histone acetyltransferases |
US7868008B2 (en) * | 2005-08-12 | 2011-01-11 | Astrazeneca Ab | Substituted isoindolones and their use as metabotropic glutamate receptor potentiators |
CA2664985A1 (fr) | 2006-09-29 | 2008-04-10 | The Board Of Trustees Of The University Of Illinois | Activateurs de l'histone acetyltransferase et inhibiteurs d'histone deacetylase dans le traitement de l'alcoolisme |
CA2574531C (fr) | 2007-01-19 | 2016-10-25 | The University Of British Columbia | Promoteurs de l'acetylation d'hat et utilisations de compositions contenant ceux-ci pour promouvoir l'immunogenicite |
JP5142858B2 (ja) | 2008-07-03 | 2013-02-13 | キヤノン株式会社 | 画像処理装置および画像処理方法 |
EA021437B1 (ru) * | 2009-09-29 | 2015-06-30 | Глэксо Груп Лимитед | Соединения, ингибирующие lrrk2 киназную активность |
JP6093180B2 (ja) * | 2009-12-10 | 2017-03-08 | トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | ヒストンアセチルトランスフェラーゼ活性化剤及びその使用 |
US10640457B2 (en) | 2009-12-10 | 2020-05-05 | The Trustees Of Columbia University In The City Of New York | Histone acetyltransferase activators and uses thereof |
WO2012081570A1 (fr) * | 2010-12-14 | 2012-06-21 | あすか製薬株式会社 | Composé de lactame ou d'un sel de ce dernier, et activateur de ppar |
CN107095864A (zh) | 2011-06-10 | 2017-08-29 | 纽约市哥伦比亚大学理事会 | 组蛋白乙酰转移酶激活剂的用途 |
WO2013058613A2 (fr) * | 2011-10-21 | 2013-04-25 | 한국생명공학연구원 | Dérivé de 2-hydroxyarylamide ou sel de qualité pharmaceutique de celui-ci, son procédé de préparation et composition pharmaceutique pour la prévention ou le traitement du cancer le contenant comme principe actif |
KR101434461B1 (ko) * | 2011-10-21 | 2014-09-01 | 한국생명공학연구원 | 2-하이드록시아릴아마이드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물 |
CN105658792B (zh) | 2012-02-28 | 2020-11-10 | 西格马-奥尔德里奇有限责任公司 | 靶向组蛋白乙酰化 |
AU2017298473A1 (en) * | 2016-07-20 | 2019-01-24 | The Trustees Of Columbia University In The City Of New York | Histone acetyltransferase activators and compositions and uses thereof |
-
2015
- 2015-03-30 JP JP2016560750A patent/JP2017511340A/ja active Pending
- 2015-03-30 US US15/300,497 patent/US20170182054A1/en not_active Abandoned
- 2015-03-30 CN CN201580027967.1A patent/CN106604913A/zh active Pending
- 2015-03-30 CA CA2944613A patent/CA2944613A1/fr not_active Abandoned
- 2015-03-30 WO PCT/US2015/023258 patent/WO2015153410A1/fr active Application Filing
- 2015-03-30 AU AU2015241177A patent/AU2015241177B2/en not_active Ceased
- 2015-03-30 EP EP18158529.0A patent/EP3398937A1/fr not_active Withdrawn
- 2015-03-30 EP EP15774440.0A patent/EP3126332A4/fr not_active Withdrawn
- 2015-03-30 BR BR112016022879A patent/BR112016022879A2/pt not_active Application Discontinuation
-
2016
- 2016-09-29 IL IL248144A patent/IL248144A0/en unknown
-
2018
- 2018-01-11 US US15/868,458 patent/US20180360842A1/en not_active Abandoned
-
2019
- 2019-12-02 US US16/700,693 patent/US11191768B2/en active Active
- 2019-12-12 AU AU2019280031A patent/AU2019280031A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1124613A (en) * | 1966-01-15 | 1968-08-21 | Hoechst Ag | ª†-resorcylic acid anilides and process for preparing them |
WO2004089470A2 (fr) * | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Utilisation pharmaceutique d'amides substitues |
WO2012088420A1 (fr) * | 2010-12-22 | 2012-06-28 | The Trustees Of Columbia University In The City Of New York | Modulateurs de l'histone acétyltransférase et leurs utilisations |
Non-Patent Citations (26)
Title |
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DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 11 May 2006 (2006-05-11), "Benzamide, N-(3,4-dichlorophenyl)-2-hydroxy-6-methoxy", XP002772349, Database accession no. 883802-63-9 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 12 April 2002 (2002-04-12), "Benzamide, 2,6-dichloro-N-(3,4-difluorophenyl)-", XP002772370, Database accession no. 405147-78-6 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 12 April 2002 (2002-04-12), "Benzamide, 2,6-dichloro-N-(3-chloro-4-fluorophenyl)-", XP002772371, Database accession no. 405147-75-3 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 13 June 2004 (2004-06-13), "Benzamide, 2,6-dichloro-N-[4-chloro-3-(trifluoromethyl)phenyl]-", XP002772369, Database accession no. 692290-31-6 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 13 September 2000 (2000-09-13), "Benzamide, N-[4-bromo-3-(trifluoromethyl)phenyl]-2,6-difluoro-", XP002772373, Database accession no. 288859-85-8 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 17 February 2008 (2008-02-17), "Benzamide, "-chloro-N-[4-chloro-3-(trifluoromethyl)phenyl]-6-fluoro-", XP002772362, Database accession no. 1004056-14-7 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 17 June 2007 (2007-06-17), "Benzamide, N-(3,4-dichlorophenyl)-2,6-difluoro-", XP002772364, Database accession no. 937648-21-0 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 18 December 2013 (2013-12-18), "Benzamide, N-(4-bromo-3-fluorophenyl)-2-fluoro-6-methoxy-", XP002772351, Database accession no. 1498238-78-0 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 19 December 2013 (2013-12-19), "Benzamide, N-(3-bromo-4-chlorophynel)-2,6-difluoro", XP002772354, Database accession no. 1499147-11-3 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2 December 2013 (2013-12-02), "Benzamide, N-(4-bromo-3-fluorophenyl)-2-chloro-6-fluoro-", XP002772356, Database accession no. 1485429-09-1 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 2 January 2014 (2014-01-02), "Benzamide, N-(3-bormo-4-chlorophenyl)-2-chloro-6-fluoro-", XP002772353, Database accession no. 15095454-88-3 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 22 December 2013 (2013-12-22), "Benzamide, N-(3-bromo-4-chlorophenyl)-2-fluoro-6-methoxy-", XP002772350, Database accession no. 1500685-94-8 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 24 March 2006 (2006-03-24), "Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2,6-difluoro-", XP002772367, Database accession no. 877975-67-2 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 25 April 2006 (2006-04-25), "Benzamide, N-(4-bromo-3-chlorophenyl)-2,6-dichloro-", XP002772366, Database accession no. 881815-48-1 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 25 August 2006 (2006-08-25), "Benzamide, 2,6-dichloro-N-(3,4-dibromophenyl)-", XP002772365, Database accession no. 904622-09-9 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 25 July 2013 (2013-07-25), "Benzamide, N-(3-chloro-4-fluorophenyl)-2-fluoro-6-(trifluoromethyl)-", XP002772358, Database accession no. 1446248-89-0 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 26 June 2001 (2001-06-26), "Benzamide, 2,6-dichloro-N-(3,4-dichlorophenyl)-", XP002772372, Database accession no. 348603-97-4 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 26 September 2004 (2004-09-26), "Benzamide, N-[4-bromo-3-(trifluoromethyl)phenyl]-2-chloro-6-fluoro-", XP002772368, Database accession no. 753469-12-4 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 28 November 2013 (2013-11-28), "Benzamide, N-(4-bromo-3-fluorophenyl)-2,6-difluoro-", XP002772357, Database accession no. 1483281-17-9 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 29 April 2012 (2012-04-29), "Benzamide, 2-chloro-6-fluoro-N-[4-fluoro-3-(trifluoromethyl)phenyl]-", XP002772359, Database accession no. 1370888-59-7 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 3 August 2008 (2008-08-03), "Benzamide, 2-chloro-N-(3,4-dichlorophenyl)-6-fluoro-", XP002772361, Database accession no. 1037912-92-7 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 3 August 2008 (2008-08-03), "Benzamide, 2-chloro-N-(3-chloro-4-fluorophenyl)-6-fluoro-", XP002772360, Database accession no. 1038026-66-2 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 4 February 2014 (2014-02-04), "Benzamide, N-(-3-bromo-4-chlorophenyl)-2,6-dichloro-", XP002772352, Database accession no. 1537042-44-6 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 5 December 2013 (2013-12-05), "Benzamide, N-(4-bromo-3-fluorophenyl)-2,6-dichloro-", XP002772355, Database accession no. 1487503-14-9 * |
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 7 February 2008 (2008-02-07), "Benzamide, 2-chloro-N-(3,4-difluorophenyl)-6-fluoro-", XP002772363, Database accession no. 1001971-32-9 * |
See also references of WO2015153410A1 * |
Also Published As
Publication number | Publication date |
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IL248144A0 (en) | 2016-11-30 |
CN106604913A (zh) | 2017-04-26 |
AU2015241177B2 (en) | 2019-09-26 |
CA2944613A1 (fr) | 2015-10-08 |
EP3398937A1 (fr) | 2018-11-07 |
JP2017511340A (ja) | 2017-04-20 |
BR112016022879A2 (pt) | 2017-10-10 |
AU2015241177A1 (en) | 2016-10-20 |
AU2019280031A1 (en) | 2020-01-16 |
US20180360842A1 (en) | 2018-12-20 |
US20170182054A1 (en) | 2017-06-29 |
US20200101078A1 (en) | 2020-04-02 |
US11191768B2 (en) | 2021-12-07 |
WO2015153410A1 (fr) | 2015-10-08 |
EP3126332A1 (fr) | 2017-02-08 |
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