EP3125897A4 - Substituierte bicyclische cyclopenta-pyrimidin-verbindungen mit antimitotischer und/oder antitumor-wirkung und verfahren zur verwendung davon - Google Patents

Substituierte bicyclische cyclopenta-pyrimidin-verbindungen mit antimitotischer und/oder antitumor-wirkung und verfahren zur verwendung davon Download PDF

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Publication number
EP3125897A4
EP3125897A4 EP15779898.4A EP15779898A EP3125897A4 EP 3125897 A4 EP3125897 A4 EP 3125897A4 EP 15779898 A EP15779898 A EP 15779898A EP 3125897 A4 EP3125897 A4 EP 3125897A4
Authority
EP
European Patent Office
Prior art keywords
antimitotic
methods
antitumor activity
bicyclic compounds
substituted cyclopenta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP15779898.4A
Other languages
English (en)
French (fr)
Other versions
EP3125897A2 (de
Inventor
Aleem Gangjee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duquesne University of the Holy Spirit
Original Assignee
Duquesne University of the Holy Spirit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/244,445 external-priority patent/US9624178B2/en
Application filed by Duquesne University of the Holy Spirit filed Critical Duquesne University of the Holy Spirit
Publication of EP3125897A2 publication Critical patent/EP3125897A2/de
Publication of EP3125897A4 publication Critical patent/EP3125897A4/de
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP15779898.4A 2014-04-03 2015-03-27 Substituierte bicyclische cyclopenta-pyrimidin-verbindungen mit antimitotischer und/oder antitumor-wirkung und verfahren zur verwendung davon Withdrawn EP3125897A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/244,445 US9624178B2 (en) 2008-07-10 2014-04-03 Substituted cyclopenta pyrimidine bicyclic compounds having antitmitotic and/or antitumor activity methods of use thereof
PCT/US2015/022871 WO2015160489A2 (en) 2014-04-03 2015-03-27 Substituted cyclopenta pyrimidine bicyclic compounds having antimitotic and/or antitumor activity and methods of use thereof

Publications (2)

Publication Number Publication Date
EP3125897A2 EP3125897A2 (de) 2017-02-08
EP3125897A4 true EP3125897A4 (de) 2017-11-15

Family

ID=54324696

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15779898.4A Withdrawn EP3125897A4 (de) 2014-04-03 2015-03-27 Substituierte bicyclische cyclopenta-pyrimidin-verbindungen mit antimitotischer und/oder antitumor-wirkung und verfahren zur verwendung davon

Country Status (4)

Country Link
EP (1) EP3125897A4 (de)
JP (1) JP6532887B2 (de)
CA (1) CA2944450C (de)
WO (1) WO2015160489A2 (de)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0067630A1 (de) * 1981-06-05 1982-12-22 Sankyo Company Limited Pyrimidin Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8309562B2 (en) * 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
US8946239B2 (en) * 2008-07-10 2015-02-03 Duquesne University Of The Holy Spirit Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
EP2519525A4 (de) * 2009-12-30 2013-06-12 Arqule Inc Substituierte pyrrolo-aminopyrimidin-verbindungen
WO2012106522A2 (en) * 2011-02-04 2012-08-09 Duquesne University Of The Holy Spirit Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0067630A1 (de) * 1981-06-05 1982-12-22 Sankyo Company Limited Pyrimidin Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ALEEM GANGJEE ET AL: "Structure-Activity Relationship and in Vitro and in Vivo Evaluation of the Potent Cytotoxic Anti-microtubule Agent N -(4-Methoxyphenyl)- N ,2,6-trimethyl-6,7-dihydro-5 H -cyclopenta[ d ]pyrimidin-4-aminium Chloride and Its Analogues As Antitumor Agents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 17, 12 September 2013 (2013-09-12), US, pages 6829 - 6844, XP055675876, ISSN: 0022-2623, DOI: 10.1021/jm400639z *
ALEEM GANGJEE ET AL: "Synthesis and Discovery of Water-Soluble Microtubule Targeting Agents that Bind to the Colchicine Site on Tubulin and Circumvent Pgp Mediated Resistance", JOURNAL OF MEDICINAL CHEMISTRY, vol. 53, no. 22, 25 November 2010 (2010-11-25), pages 8116 - 8128, XP055120721, ISSN: 0022-2623, DOI: 10.1021/jm101010n *
CHENXIAO DA ET AL: "How to Deal with Low-Resolution Target Structures: Using SAR, Ensemble Docking, Hydropathic Analysis, and 3D-QSAR to Definitively Map the [alpha][beta]-Tubulin Colchicine Site", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 18, 26 September 2013 (2013-09-26), US, pages 7382 - 7395, XP055675899, ISSN: 0022-2623, DOI: 10.1021/jm400954h *
DAO-LIN WANG ET AL: "New Synthetic Approach to 4- N -Arylaminoazuleno[2,1- d ]pyrimides", SYNTHETIC COMMUNICATIONS, vol. 39, no. 13, 9 June 2009 (2009-06-09), PHILADELPHIA, PA; US, pages 2329 - 2338, XP055413566, ISSN: 0039-7911, DOI: 10.1080/00397910802654807 *
See also references of WO2015160489A2 *

Also Published As

Publication number Publication date
JP6532887B2 (ja) 2019-06-19
EP3125897A2 (de) 2017-02-08
WO2015160489A3 (en) 2016-03-31
CA2944450A1 (en) 2015-10-22
CA2944450C (en) 2023-03-21
JP2017512805A (ja) 2017-05-25
WO2015160489A2 (en) 2015-10-22

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