EP3125897A4 - Substituted cyclopenta pyrimidine bicyclic compounds having antimitotic and/or antitumor activity and methods of use thereof - Google Patents
Substituted cyclopenta pyrimidine bicyclic compounds having antimitotic and/or antitumor activity and methods of use thereof Download PDFInfo
- Publication number
- EP3125897A4 EP3125897A4 EP15779898.4A EP15779898A EP3125897A4 EP 3125897 A4 EP3125897 A4 EP 3125897A4 EP 15779898 A EP15779898 A EP 15779898A EP 3125897 A4 EP3125897 A4 EP 3125897A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- antimitotic
- methods
- antitumor activity
- bicyclic compounds
- substituted cyclopenta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/244,445 US9624178B2 (en) | 2008-07-10 | 2014-04-03 | Substituted cyclopenta pyrimidine bicyclic compounds having antitmitotic and/or antitumor activity methods of use thereof |
PCT/US2015/022871 WO2015160489A2 (en) | 2014-04-03 | 2015-03-27 | Substituted cyclopenta pyrimidine bicyclic compounds having antimitotic and/or antitumor activity and methods of use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3125897A2 EP3125897A2 (en) | 2017-02-08 |
EP3125897A4 true EP3125897A4 (en) | 2017-11-15 |
Family
ID=54324696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP15779898.4A Withdrawn EP3125897A4 (en) | 2014-04-03 | 2015-03-27 | Substituted cyclopenta pyrimidine bicyclic compounds having antimitotic and/or antitumor activity and methods of use thereof |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP3125897A4 (en) |
JP (1) | JP6532887B2 (en) |
CA (1) | CA2944450C (en) |
WO (1) | WO2015160489A2 (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0067630A1 (en) * | 1981-06-05 | 1982-12-22 | Sankyo Company Limited | Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8309562B2 (en) * | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
US8946239B2 (en) | 2008-07-10 | 2015-02-03 | Duquesne University Of The Holy Spirit | Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof |
BR112012016376A2 (en) | 2009-12-30 | 2019-09-24 | Arqule Inc | substituted pyrrolo-aminopyrimide compounds |
CA2826295C (en) * | 2011-02-04 | 2020-10-20 | Duquesne University Of The Holy Spirit | Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient |
-
2015
- 2015-03-27 CA CA2944450A patent/CA2944450C/en active Active
- 2015-03-27 EP EP15779898.4A patent/EP3125897A4/en not_active Withdrawn
- 2015-03-27 JP JP2016559903A patent/JP6532887B2/en not_active Expired - Fee Related
- 2015-03-27 WO PCT/US2015/022871 patent/WO2015160489A2/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0067630A1 (en) * | 1981-06-05 | 1982-12-22 | Sankyo Company Limited | Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them |
Non-Patent Citations (2)
Title |
---|
DAO-LIN WANG ET AL: "New Synthetic Approach to 4- N -Arylaminoazuleno[2,1- d ]pyrimides", SYNTHETIC COMMUNICATIONS, vol. 39, no. 13, 9 June 2009 (2009-06-09), PHILADELPHIA, PA; US, pages 2329 - 2338, XP055413566, ISSN: 0039-7911, DOI: 10.1080/00397910802654807 * |
See also references of WO2015160489A2 * |
Also Published As
Publication number | Publication date |
---|---|
JP6532887B2 (en) | 2019-06-19 |
WO2015160489A3 (en) | 2016-03-31 |
CA2944450A1 (en) | 2015-10-22 |
WO2015160489A2 (en) | 2015-10-22 |
CA2944450C (en) | 2023-03-21 |
EP3125897A2 (en) | 2017-02-08 |
JP2017512805A (en) | 2017-05-25 |
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