EP3113631A1 - Probiotische stabilisierung - Google Patents
Probiotische stabilisierungInfo
- Publication number
- EP3113631A1 EP3113631A1 EP14803016.6A EP14803016A EP3113631A1 EP 3113631 A1 EP3113631 A1 EP 3113631A1 EP 14803016 A EP14803016 A EP 14803016A EP 3113631 A1 EP3113631 A1 EP 3113631A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- probiotic
- composition
- nutritional composition
- nutritional
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 description 1
- AYEKOFBPNLCAJY-UHFFFAOYSA-O thiamine pyrophosphate Chemical compound CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N AYEKOFBPNLCAJY-UHFFFAOYSA-O 0.000 description 1
- 235000008170 thiamine pyrophosphate Nutrition 0.000 description 1
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- IWLROWZYZPNOFC-UHFFFAOYSA-N thiamine(1+) triphosphate(1-) Chemical compound CC1=C(CCOP(O)(=O)OP(O)(=O)OP(O)([O-])=O)SC=[N+]1CC1=CN=C(C)N=C1N IWLROWZYZPNOFC-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 1
- 235000015149 toffees Nutrition 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 239000011728 vitamin K2 Substances 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 229940041603 vitamin k 3 Drugs 0.000 description 1
- 239000001717 vitis vinifera seed extract Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 235000008939 whole milk Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
- 235000010930 zeaxanthin Nutrition 0.000 description 1
- 239000001775 zeaxanthin Substances 0.000 description 1
- 229940043269 zeaxanthin Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
Definitions
- the present disclosure relates to the stabilization of biological material for ingestion by an individual. More particularly, the present disclosure relates to a stabilization mixture comprising at least one phospholipid and at least one glyceride, which together provide improved stability to a probiotic organism when the probiotic is included in a nutritional composition.
- the disclosure also includes probiotic stabilization methods.
- compositions for supplementing the nutrition of both humans and animals may be provided to alter, reduce or increase the microflora within an individual's gut so as to cause a desired effect on digestion.
- supplementation may cultivate an improved microflora for individuals, including humans, based upon the alteration of specific bacteria within the human's gastrointestinal (Gl) tract. This style of supplementation may be conducted through the use of probiotics, which are understood to be live
- microorganisms that when administered in effective amounts confer a health or nutritional benefit to the host.
- One of the more common types of probiotics is a lactic acid bacterium which is able to convert sugars and other carbohydrates into lactic acid. This conversion lowers the pH within the gut of the host and provides fewer opportunities for harmful organisms to grow and cause problems through gastrointestinal infections.
- a common technological challenge is introducing probiotics into the host in an appropriate manner, both for the maintenance of the probiotics as well as for the health and enjoyment of an individual.
- Current technologies include the utilization of encapsulation and stabilization techniques for shielding the probiotics with a protective layer or matrix so that the protected microbe may pass to the appropriate location within the individual's Gl tract.
- probiotics can provide a variety of benefits to a host, such as maintaining a healthy gastrointestinal flora, enhancing immunity, protecting against diarrhea, atopic dermatitis and other diseases, etc.
- a host such as maintaining a healthy gastrointestinal flora, enhancing immunity, protecting against diarrhea, atopic dermatitis and other diseases, etc.
- probiotics there is a need for probiotics to be administered in various geographic locations, including tropical climates, where the viability of the probiotic could be compromised.
- Conventional encapsulation and stabilization techniques possess a chemical makeup that is ill- suited for infant formulas and/or for use by children, or known techniques have poor stability characteristics that significantly limit commercial opportunities.
- the present disclosure is directed to a nutritional composition comprising a protein source and a probiotic, wherein the probiotic is stabilized in a protective matrix, the protective matrix includes at least one
- phospholipid and at least one glyceride.
- the nutritional composition comprises viable microbial cells, such as viable Lactobacillus rhamnosus cells.
- the matrix may comprise a source of hydrolyzed protein, pectin, an additional lipid, or any
- the nutritional composition may be a powdered formula, such as a powdered infant formula.
- the at least one glyceride may include a monoglyceride, a diglyceride, or any combination thereof.
- the present disclosure is directed to a method for protecting a viable probiotic for use in a powdered nutritional composition, the method includes the steps of (i) providing a viable probiotic, (ii) preparing a protective matrix for the probiotic by blending together at least one phospholipid and at least one glyceride, and (iii) combining the viable probiotic, the protective matrix and water to produce a mixture; and (iv) drying the mixture of step (iii) to a final moisture content of about 4% or less.
- This method may comprise the additional step of a) adding the dried mixture to a powdered nutritional product or b) enclosing the dried mixture of step (iv) in a capsule.
- the viable probiotic may be Lactobacillus rhamnosus, Bifidobacterium longum BB536,
- the stabilization mixture advantageously provides for an extension of the shelf-life of probiotics.
- the stabilization mixture may be combined with the probiotic in a variety of methods including freeze-drying, air-drying, vacuum-drying, spray-drying and any combination thereof for preserving the probiotic.
- the present disclosure provides a stabilization technique and a stabilized mixture (also referred to herein as a "stabilization mixture” or a “protective matrix”) that may be used for improving the stability of a biological material (also referred to herein as a "substrate").
- the stabilized substrate may be a probiotic, wherein the various health benefits associated with the stabilized probiotic may be conferred to an individual upon ingesting a nutritional composition containing the stabilized probiotic.
- probiotics While probiotics have been recognized as nutritionally beneficial, it is generally thought that the beneficial effects of probiotics are maximized if a probiotic microorganism is ingested by a subject when the microorganism is still alive. Thus, it is desirable for a viable probiotic to survive the conditions of manufacturing and of placement into a consumable nutritional composition, such as a food or beverage, as well as to survive the subsequent shipping and storage time before the product is ingested and introduced to a subject's gastrointestinal tract. Many conventional probiotic compositions utilize an extremely high count of viable cells, with the understanding that a significant number of cells ultimately lose viability and die during the manufacturing process, transport, and storage.
- a lipid component comprising at least one phospholipid and/or at least one glyceride is incorporated into a protective matrix.
- the phospholipid and/or glyceride increase the stability of probiotics that are protected by the matrix.
- infant- and children-compatible probiotics can be stabilized with a matrix including at least one phospholipid and/or at least one glyceride.
- the matrix further comprises at least one additional lipid, that is, at least one lipid in addition to the phospholipid and glyceride.
- the stabilized probiotics can be used in multiple environments, as the probiotics exhibit an improved viability.
- probiotics stabilized by the protective matrix of the present disclosure can be incorporated into nutritional compositions and shipped over extended distances subjected to potentially damaging temperature fluctuations, as the probiotics will maintain viability even after extended transportation and storage time, due to the improved stability of the stabilized mixture.
- the present method of providing stabilization to probiotics may include the use of a matrix for stabilizing a biological material, wherein the matrix includes a phospholipid, a glyceride, and additional components, such as one or more additional lipids, one or more carbohydrates and/or a compound binder.
- the protective matrix may be utilized for a variety of substances, in an embodiment, it is utilized to protect at least one probiotic, such as Lactobacillus rhamnosus.
- Lactobacillus rhamnosus ⁇ s understood to possess relatively good bio- stability while having a high avidity for human intestinal mucosal cells.
- Lactobacillus rhamnosus ' ⁇ s thought to colonize the digestive tract and to balance intestinal microflora.
- the protective matrix provides for improved stability of the probiotic, meaning that a greater percentage of the probiotic cells are viable after processing, transportation and storage conditions. Specifically, the shelf life of viable probiotics is improved when compared to other known stabilization techniques.
- the protective matrix of the present disclosure may be used in a multiplicity of processes for forming a stabilized probiotic product. These processes include freezing, flash-freezing, freeze-drying, ambient air drying, vacuum drying, spray drying, low temperature drying, and any combination thereof.
- the resulting stabilized probiotic whether alone or integrated into a nutritional composition, possesses effective viability in a wide range of temperatures and conditions while displaying improved shelf-life.
- the stabilized probiotic may be incorporated into a variety of prenatal, infant and children's nutritional products for improving their gut microflora while simultaneously providing nutrition to the infant or child.
- the disclosure is directed to a method for stabilizing a biological material in a nutritional composition.
- Still another embodiment is a protective matrix for a probiotic.
- a further embodiment is a method of increasing the shelf life of probiotics comprising stabilizing the probiotic with a stabilization mixture including a phospholipid, a glyceride or any combination thereof.
- the present disclosure provides a novel stabilization mixture and method that provides stability and protection to biological materials, such as viable microorganisms.
- the present disclosure includes a stabilization mixture comprising a phospholipid, and a glyceride, which together provide a protective matrix resulting in an increased shelf-life over unprotected probiotics.
- an “effective amount” as used herein is generally defined as an amount of an agent that provides an observable result within the subject administered thereto.
- Nutritional composition means a substance or formulation that satisfies at least a portion of a subject's nutrient requirements.
- nutritional composition(s) may refer to liquids, powders, gels, pastes, solids, concentrates, suspensions, or ready-to-use forms of enteral formulas, oral formulas, formulas for infants, formulas for pediatric subjects, formulas for children, growing-up milks and/or formulas for adults.
- Enteral administration includes oral feeding, intragastric feeding, transpyloric administration, or any other administration into the digestive tract.
- Administration is broader than “enteral administration” and includes parenteral administration or any other route of administration by which a substance is taken into a subject's body.
- a pediatric subject means a human less than 13 years of age. In some embodiments, a pediatric subject refers to a human subject that is less than 8 years old. In other embodiments, a pediatric subject refers to a human subject between 1 and 6 years of age. In still further embodiments, a pediatric subject refers to a human subject between 6 and 12 years of age.
- infant means a human subject ranging in age from birth to not more than one year and includes infants from 0 to 12 months corrected age.
- corrected age means an infant's chronological age minus the amount of time that the infant was born premature. Therefore, the corrected age is the age of the infant if it had been carried to full term.
- the term infant includes low birth weight infants, very low birth weight infants, and preterm infants.
- pre-term infant is an infant born after less than about 37 weeks gestation.
- a "full-term infant” as used herein means an infant born after at least about 37 weeks gestation.
- Child means a subject ranging in age from 12 months to about 12 years.
- a child is a subject between the ages of 1 and 12 years old.
- the terms “children” or “child” refer to subjects that are between one and about six years old, or between about seven and about 12 years old. In other embodiments, the terms “children” or “child” refer to any range of ages between 12 months and about 12 years.
- Children's nutritional product refers to a composition that satisfies at least a portion of the nutrient requirements of a child.
- a growing-up milk (GUM) is an example of a children's nutritional product.
- hydrolyzed protein means a product of protein hydrolysis.
- hydrolyzed protein and protein hydrolysate are used interchangeably to describe products of protein hydrolysis; extensively hydrolyzed protein is used to describe products of protein hydrolysis where at least 70%, more preferably at least about 90%, of the hydrolyzed protein has a molecular weight of less than 2000 Daltons.
- degree of hydrolysis refers to the extent to which peptide bonds are broken by a hydrolysis method.
- protein-free means containing no measurable amount of protein, as measured by standard protein detection methods such as sodium dodecyl (lauryl) sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) or size exclusion chromatography.
- the nutritional composition is substantially free of protein, wherein “substantially free” is defined hereinbelow.
- infant formula means a composition that satisfies at least a portion of the nutrient requirements of an infant.
- the content of an infant formula is dictated by the federal regulations set forth at 21 C.F.R. Sections 100, 106, and 107. These regulations define macronutrient, vitamin, mineral, and other ingredient levels in an effort to simulate the nutritional and other properties of human breast milk.
- growing-up milk refers to a broad category of nutritional compositions intended to be used as a part of a diverse diet in order to support the normal growth and development of a child between the ages of about 1 and about 6 years of age.
- milk-based means comprising at least one component that has been drawn or extracted from the mammary gland of a mammal.
- a milk-based nutritional composition comprises components of milk that are derived from domesticated ungulates, ruminants or other mammals or any combination thereof.
- milk-based means comprising bovine casein, whey, lactose, or any combination thereof.
- milk-based nutritional composition may refer to any composition comprising any milk-derived or milk- based product known in the art.
- “Nutritionally complete” means a composition that may be used as the sole source of nutrition, which would supply essentially all of the required daily amounts of vitamins, minerals, and/or trace elements in combination with proteins, carbohydrates, and lipids. Indeed, “nutritionally complete” describes a nutritional composition that provides adequate amounts of carbohydrates, lipids, essential fatty acids, proteins, essential amino acids, conditionally essential amino acids, vitamins, minerals and energy required to support normal growth and development of a subject.
- composition which is "nutritionally complete” for the preterm infant will, by definition, provide qualitatively and quantitatively adequate amounts of all carbohydrates, lipids, essential fatty acids, proteins, essential amino acids, conditionally essential amino acids, vitamins, minerals, and energy required for growth of the preterm infant.
- the composition which is "nutritionally complete” for the term infant will, by definition, provide qualitatively and quantitatively adequate amounts of all carbohydrates, lipids, essential fatty acids, proteins, essential amino acids, conditionally essential amino acids, vitamins, minerals, and energy required for growth of the term infant.
- composition which is "nutritionally complete” for a child will, by definition, provide qualitatively and quantitatively adequate amounts of all carbohydrates, lipids, essential fatty acids, proteins, essential amino acids, conditionally essential amino acids, vitamins, minerals, and energy required for growth of a child.
- essential refers to any nutrient that cannot be synthesized by the body in amounts sufficient for normal growth and to maintain health and that, therefore, must be supplied by the diet.
- conditionally essential as applied to nutrients means that the nutrient must be supplied by the diet under conditions when adequate amounts of the precursor compound is unavailable to the body for endogenous synthesis to occur.
- probiotic means a microorganism with low or no
- a "viable probiotic” means a live or active microorganism that exerts beneficial effects on the health of the host.
- inactivated probiotic or “inactivated LGG” means a probiotic wherein the metabolic activity or reproductive ability of the referenced probiotic or Lactobacillus rhamnosus GG (LGG) organism has been reduced or destroyed.
- the probiotic(s) may be viable or non-viable.
- viable refers to live microorganisms.
- non-viable or non-viable probiotic means non-living probiotic microorganisms, their cellular components and/or metabolites thereof. Such non-viable probiotics may have been heat-killed or otherwise inactivated, but they retain the ability to favorably influence the health of the host.
- the probiotics useful in the present disclosure may be naturally-occurring, synthetic or developed through the genetic manipulation of organisms, whether such source is now known or later developed.
- Prebiotic means a non-digestible food ingredient that beneficially affects the host by selectively stimulating the growth and/or activity of one or a limited number of bacteria in the digestive tract that can improve the health of the host.
- phytonutrient means a chemical compound that occurs naturally in plants. Phytonutrients may be included in any plant-derived substance or extract.
- the term “phytonutrient(s)” encompasses several broad categories of compounds produced by plants, such as, for example, polyphenolic compounds, anthocyanins, proanthocyanidins, and flavan-3-ols (i.e. catechins, epicatechins), and may be derived from, for example, fruit, seed or tea extracts.
- phytonutrient includes all carotenoids, phytosterols, thiols, and other plant-derived compounds.
- ⁇ -glucan means all ⁇ -glucan, including specific types of ⁇ -glucan, such as ⁇ -1 ,3-glucan or ⁇ -1 ,3;1 ,6-glucan. Moreover, ⁇ -1 ,3;1 ,6-glucan is a type of ⁇ -1 ,3- glucan. Therefore, the term "P-1 ,3-glucan” includes -1 ,3;1
- Pectin means any naturally-occurring oligosaccharide or
- pectin may comprise molecules having a diverse chain length formed by D-galacturonopyranosyl. Different varieties and grades of pectin having varied physical and chemical properties are known in the art. Indeed, the structure of pectin can vary significantly between plants, between tissues, and even within a single cell wall. Generally, pectin is made up of negatively charged acidic sugars (galacturonic acid), and some of the acidic groups are in the form of a methyl ester group. The degree of esterification of pectin is a measure of the percentage of the carboxyl groups attached to the galactopyranosyluronic acid units that are esterified with methanol.
- Pectin having a degree of esterification of less than 50% are classified as low-ester, low methoxyl, or low methylated (“LM”) pectins, while those having a degree of esterification of 50% or greater than 50%, (i.e., more than 50% of the carboxyl groups are methylated) are classified as high-ester, high methoxyl or high methylated (“HM”) pectins.
- Very low (“VL”) pectins, a subset of low methylated pectins have a degree of esterification that is less than approximately 15%.
- pectin molecules have the ability to interact with themselves and/or with divalent cations, such as calcium, through electrostatic interactions to form high molecular weight networks and gels.
- divalent cations such as calcium
- the degree of esterification influences the extent of these intermolecular interactions.
- Lipid refers to hydrophobic molecule(s) that may include free fatty acid(s) and/or molecules in which fatty acids are esterified to a hydroxyl group of (i) a saccharide, such as a mono- or di-saccharide, (ii) an alcohol, wherein the alcohol may comprise, for example, a long- or medium- carbon chain length (10 -20 units), or (iii) a glycerol. These esterified or free fatty acids may be linear chains, saturated or unsaturated.
- the lipid component comprises glycerides, phospholipids, sphingosine-derived molecules, such as gangliosides, cerebrosides, and sphingomyelins, or any combination thereof. And in certain embodiments, the lipid component further includes molecules that are hydrophobic in nature, such as steroids, carotenoids, and/or fat-soluble vitamins.
- Glyceride means any molecule derived from a glycerol or a sugar backbone in which one or more of the hydroxyl groups is esterified with a fatty acid.
- the glyceride component comprises mono-glycerides, di- glycerides, mono-sugar esters, di-sugar esters, or a combination thereof.
- Phospholipid means any molecule derived from a phosphatidic acid in which one or two carbons from the glycerol backbone are esterified to a fatty acid, and one of the terminal carbons is esterified to a phosphate group.
- the phosphate group is a phosphodiester also esterified to another functional molecule, such as choline, serine, or inositol.
- the phospholipid component comprises glycerophospholipid and/or
- the phospholipid component may comprise lyso- phospholipids wherein one of the carbons from the glycerol backbone remains as a non-esterified hydroxyl group.
- the phospholipid component comprises lecithin, which may, for example, be extracted from soybeans or from egg yolk and may comprise a combination of phosphatidyl-choline, phosphatidyl-inositol and phosphatidyl serine.
- the phospholipid may comprise soybean lecithin, egg lecithin, a milk fat derived phospholipid or a combination thereof.
- All amounts specified as administered "per day” may be delivered in one unit dose, in a single serving or in two or more doses or servings administered over the course of a 24 hour period.
- the nutritional composition of the present disclosure may be
- substantially free of any optional or selected ingredients described herein means that the selected composition may contain less than a functional amount of the optional ingredient, typically less than 0.1 % by weight, and also, including zero percent by weight of such optional or selected ingredient.
- compositions of the present disclosure can comprise, consist of, or consist essentially of the essential elements and limitations of the embodiments described herein, as well as any additional or optional ingredients, components or limitations described herein or otherwise useful in nutritional compositions.
- At least one phospholipid and at least one glyceride are utilized as components of a protective matrix for stabilizing biological material.
- Lactobacillus rhamnosus beyond what was previously known in the art.
- the lipid component of the protective matrix may comprise, but is not limited to animal sources, e.g., milk fat, butter, butter fat, milk phospholipids, egg yolk lipid, egg yolk phospholipids; marine sources, such as fish oils, marine oils, single cell oils; vegetable and plant oils, such as corn oil, canola oil, sunflower oil, soybean oil, soybean phospholipids, palmolein, coconut oil, high oleic sunflower oil, evening primrose oil, rapeseed oil, olive oil, flaxseed (linseed) oil, cottonseed oil, high oleic safflower oil, palm stearin, palm kernel oil, wheat germ oil; medium chain triglyceride oils and emulsions and esters of fatty acids; and any combinations thereof.
- animal sources e.g., milk fat, butter, butter fat, milk phospholipids, egg yolk lipid, egg yolk phospholipids
- marine sources such as fish oils, marine oils, single cell oils
- vegetable and plant oils such as corn
- the stabilization mixture comprises between about 0.5 and about 50 grams of a lipid component per 100 grams of the mixture on a dry basis. In certain embodiments, the stabilization mixture comprises between about 2.5 and about 30 grams of a lipid component per 100 grams of the mixture on a dry basis.
- the stabilization mixture may comprise a phospholipid component.
- the stabilization mixture includes between about 0.5 and about 2 grams of a phospholipid component per 100 grams of the mixture on a dry basis. In some embodiments, the stabilization mixture comprises between about 0.75 and about 1.25 grams of a phospholipid component per 100 grams of the mixture on a dry basis.
- the stabilization mixture may include a glyceride component.
- the stabilization mixture comprises between about 0.5 and about 2 grams of a glyceride component per 100 grams of the mixture on a dry basis. In certain embodiments, the stabilization mixture comprises between about 0.75 and about 1.25 grams of a glyceride component per 100 grams of the mixture on a dry basis.
- the glyceride component may comprise monoglyceride(s), diglyceride(s), or any combination thereof.
- the majority component of the stabilization mixture is one or more carbohydrates, which may include polysaccharides, disaccharides and monosaccharides.
- the protective matrix may include lactulose, lactosucrose, raffinose, gluco-oligosaccharide, trehalose, inulin, polydextrose, galacto-oligosaccharide, fructo-oligosaccharide, isomalto-oligosaccharide, soybean oligosaccharides, lactosucrose, xylo- oligosaccharide, chito-oligosaccharide, manno-oligosaccharide, aribino- oligosaccharide, siallyl-oligosaccharide, fuco-oligosaccharide, gentio- oligosaccharides, and/or any combination thereof.
- the protective matrix includes a first carbohydrate chosen from: sucrose, maltose, lactose, trehalose, maltotriose, maltodextrin having a dextrose equivalent of about 2 to about 6, and any combination thereof.
- the protective matrix includes a second carbohydrate chosen from: inulin, polydextrose,
- galactooligosaccharide fructooligosaccharide, starch, maltodextrin having a dextrose equivalent of greater than about 8, and any combination thereof.
- the stabilization mixture may comprise between about 50 and about 80 grams of a first carbohydrate per 100 grams of the mixture on a dry basis; between about 60 and about 70 grams of a first carbohydrate per 100 grams of the mixture on a dry basis; or between about 65 and about 70 grams of a first carbohydrate per 100 grams of the mixture on a dry basis.
- the first carbohydrate may be chosen from: sucrose, maltose, lactose, trehalose, maltotriose, maltodextrin having a dextrose equivalent of about 2 to about 6, and any combination thereof.
- the stabilization mixture may also comprise between about 1 and about 10 grams of a second carbohydrate per 100 grams of the mixture on a dry basis; between about 4 and about 6 grams of a second carbohydrate per 100 grams of the mixture on a dry basis; or about 5 grams of a second carbohydrate per 100 grams of the mixture on a dry basis.
- the second carbohydrate is chosen from: inulin, polydextrose, galactooligosaccharide, fructooligosaccharide, starch, maltodextrin having a dextrose equivalent of greater than about 8, and any combination thereof.
- a further component of the stabilization mixture can be a compound binder (also referred to as a gelling agent), which may act as a thickener and produce a gel-like consistency.
- Compound binders that may be included in the protective matrix of the present disclosure include alginates, such as sodium alginate, pectin, chitosan, carboxymethylcellulose, and mixtures thereof, among others.
- alginates such as sodium alginate, pectin, chitosan, carboxymethylcellulose, and mixtures thereof, among others.
- the incorporation of the compound binder provides for the formation of a viscous consistency providing for efficient matrix formation and a structural quality suitable for subsequent drying.
- a compound binder can, in some embodiments, form a gum-like material and increase the viscosity of mixtures to which it is added. Additionally, the compound binder may also provide for greater ease in mixing of the components together. For instance, sodium alginate may also possess emulsifier characteristics.
- the stabilization mixture may comprise LM pectin, HM pectin, VL pectin, or any mixture thereof.
- the included pectin may be soluble in water.
- Pectins for use herein typically have a peak molecular weight of 8,000 Daltons or greater.
- the pectins of the present disclosure have a preferred peak molecular weight of between 8,000 and about 500,000, more preferred is between about 10,000 and about 200,000 and most preferred is between about 15,000 and about 100,000 Daltons.
- the pectin of the present disclosure may be hydrolyzed pectin.
- the protective matrix comprises hydrolyzed pectin having a molecular weight less than that of intact or unmodified pectin.
- the hydrolyzed pectin of the present disclosure can be prepared by any means known in the art to reduce molecular weight.
- the protective matrix comprises partially hydrolyzed pectin.
- the partially hydrolyzed pectin has a molecular weight that is less than that of intact or unmodified pectin but more than 3,300 Daltons.
- the stabilization mixture may comprise between about 0.5 and about 5 grams of a compound binder, such as sodium alginate and/or pectin, per 100 grams of the mixture on a dry basis. In certain embodiments, the stabilization mixture comprises between about 1 and about 3 grams of a compound binder per 100 grams of the mixture on a dry basis. And in an embodiment, the stabilization mixture comprises about 2 grams of a compound binder per 100 grams of the mixture on a dry basis.
- a compound binder such as sodium alginate and/or pectin
- the stabilization mixture may also comprise at least one starch, source of starch and/or starch component.
- the stabilization mixture may comprise native or modified starches, such as, for example, waxy corn starch, waxy rice starch, waxy potato starch, waxy tapioca starch, corn starch, rice starch, potato starch, tapioca starch, wheat starch or any mixture thereof.
- the stabilization mixture may also include additional ingredients that provide further benefits to either the probiotic or the individual ingesting the stabilized probiotic. These ingredients may comprise minerals, vitamins,
- antioxidants trace elements, sterols, antioxidants, fatty acids, functional molecules, and any combination thereof.
- Other ingredients may include resistant starches, high amylose starches, guar, and locust bean gum, agar, xanthan, carrageenans, glucans, and any combination thereof.
- the stabilization mixture may comprise between about 5 and about 90 grams of probiotic and/or other biological material per 100 grams of the mixture on a dry basis. In some embodiments, the stabilization mixture comprises between about 50 and about 90 grams of probiotic and/or other biological material per 100 grams of the stabilization mixture. In certain embodiments, the stabilization mixture comprises between about 9 and about 12 grams of probiotic and/or other biological material per 100 grams of the mixture on a dry basis. And in an embodiment, the stabilization mixture comprises from about 10.2 to about 1 1.4 grams of probiotic and/or other biological material per 100 grams of the mixture on a dry basis.
- the concentration of the probiotic, for instance LGG, in the protective matrix is from about 1 x 10 6 to about 1 x 10 14 cfu per gram of the protective matrix, more preferably from about 1 x 10 9 to about 1 x 10 11 cfu per gram of the protective matrix.
- the stabilization mixture may be used to provide stability to a probiotic organism which may exert a beneficial effect on the health and welfare of individuals.
- suitable probiotics include but are not limited to yeasts such as
- Saccharomyces cereviseae molds such as Aspergillus, Rhizopus, Mucor, and bacteria such as Lactobacillus.
- suitable probiotic micro-organisms are: Aspergillus niger, A. oryzae, Bacillus coagulans, B. lent us, B. licheniformis, B.
- the stabilized probiotic(s) may be viable or non-viable.
- the stabilized probiotics useful in the present disclosure may be naturally-occurring, synthetic or developed through the genetic manipulation of organisms, whether such new source is now known or later developed.
- Lactobacillus rhamnosus GG is described in U.S. Patent
- the selected probiotic is preferably concentrated to a wet paste-like consistency prior to combining with the stabilization mixture of the present disclosure. Starting with probiotics in dry form is also an alternative. Concentration levels of selected probiotics include concentrations of from about 3X to about 20X though may include lesser or greater concentrations depending upon the specific probiotic biomass and subsequent processing steps.
- the preparation of a stabilized probiotic includes the steps of concentrating the selected probiotic or probiotics; providing components of the stabilization mixture in desired quantities; mixing the stabilization mixture with the concentrated probiotic; drying the stabilized probiotic and either packaging or combining the stabilized probiotic into a nutritional product, such as an infant formula.
- the present disclosure is directed to a method for protecting a viable probiotic for use in a nutritional composition
- the method may include the steps of providing a viable probiotic, preparing a protective matrix for the probiotic by blending (i) a phospholipid component and (ii) a glyceride
- the viable probiotic, the protective matrix and water then combining the viable probiotic, the protective matrix and water to produce a mixture and drying the mixture to a final moisture content of about 4% or less, and further adding the dried mixture to a powdered nutritional product or to a capsule.
- the multiple constituents may be varied in some embodiments as described herein and as shown in Tables 1 -4.
- the lipid may comprise from about 10% to 50% (w/w) of the stabilization mixture.
- the stabilization mixture may comprise about 5% to about 25% (w/w) of a phospholipid component, and from about 5% to about 25% (w/w) of a glyceride component.
- the stabilization mixture may comprise from about 5% to about 25% (w/w) of a phospholipid component, from about 2.5 to about 12.5% (w/w) of a glyceride component, and from about 2.5% to about 12.5% (w/w) of an additional/other lipid component.
- the total lipids of the stabilization mixture may comprise from about 3% to about 17% (w/w) of a phospholipid component, from about 3 to about 17% (w/w) of a glyceride component, and from about 3% to about 17% (w/w) of an additional/other lipid component.
- the stabilized probiotic may be packaged and sold commercially or may be instead combined with a variety of nutritional products or encapsulated with other functional components, such as docosahexaenoic acid.
- Such nutritional products may include both infant formulas and children's products useful for applications where one desires to incorporate a probiotic into a nutritional product that necessitates an improved shelf-life and stability.
- Table 1 presents a sample embodiment of a stabilized probiotic mixture/protective matrix according to the present disclosure.
- TABLE 1 An embodiment of the protective matrix
- Table 2 presents a sample embodiment of a stabilized probiotic mixture/protective matrix according to the present disclosure.
- Table 3 presents yet another example embodiment of a stab probiotic mixture/protective matrix according to the present disclosure.
- Table 4 also provides an example embodiment of a stabilized probiotic mixture/protective matrix according to the present disclosure.
- TABLE 4 An embodiment of the protective matrix
- a stabilized probiotic prepared as described hereinabove may be combined with a nutritional product to form a novel nutritional composition.
- the stabilized probiotic may be combined with a nutritional product, such as an infant formula or children's nutritional product, to form a stabilized nutritional composition.
- a nutritional product such as an infant formula or children's nutritional product
- the stabilized probiotic may be combined with a human milk fortifier, which is added to human milk in order to enhance the nutritional value of human milk.
- the stabilized probiotic of the disclosure may be combined with a nutritional product that provides minimal, partial, or total nutritional support.
- a nutritional product that provides minimal, partial, or total nutritional support.
- Such nutritional product(s) may be nutritional supplements or meal replacements.
- the stabilized probiotic can be intermixed with food or other nutritional products prior to ingestion by a subject.
- the nutritional product for combination with the stabilized probiotic may, but need not, be nutritionally complete.
- the combination of the stabilized probiotic with a nutritional product may produce a nutritional composition that is nutritionally complete.
- the nutritional composition of the disclosure is nutritionally complete and contains suitable types and amounts of lipid, carbohydrate, protein, vitamins and minerals.
- the stabilized probiotic created by the present disclosure may be combined with a nutritional product provided in any form known in the art, including a powder, a gel, a suspension, a paste, a solid, a liquid, a liquid concentrate, or a ready-to-use product.
- the nutritional product is an infant formula, especially an infant formula adapted for use as sole source nutrition for an infant.
- the nutritional products described for combining with the stabilized probiotic may be administered enterally.
- a stabilized/protected probiotic prepared as described above may be combined with a nutritional product to form a novel nutritional composition.
- the nutritional composition may comprise any additional fat or lipid source that is known or used in the art, including but not limited to, animal sources, e.g., milk fat, butter, butter fat, egg yolk lipid; marine sources, such as fish oils, marine oils, single cell oils; vegetable and plant oils, such as corn oil, canola oil, sunflower oil, soybean oil, palmolein, coconut oil, high oleic sunflower oil, evening primrose oil, rapeseed oil, olive oil, flaxseed (linseed) oil, cottonseed oil, high oleic safflower oil, palm stearin, palm kernel oil, wheat germ oil; medium chain triglyceride oils and emulsions and esters of fatty acids; and any combinations thereof.
- the amount of lipid or fat in the nutritional composition typically varies from about 1 to about 7 g/100 kcal.
- the nutritional composition may comprise a source of bovine milk protein.
- the source of bovine milk protein may include, but is not limited to, milk protein powders, milk protein concentrates, milk protein isolates, nonfat milk solids, nonfat milk, nonfat dry milk, whey protein, whey protein isolates, whey protein concentrates, sweet whey, acid whey, casein, acid casein, caseinate (e.g. sodium caseinate, sodium calcium caseinate, calcium caseinate) and any combination thereof.
- the nutritional composition may comprise intact protein.
- the proteins of the nutritional composition are provided as a combination of both intact proteins and partially hydrolyzed proteins, with a degree of hydrolysis of from about 4% and 10%. Certain of these
- embodiments can be extremely hypoallergenic, as both the stabilizer and the protein of the nutritional product contain only hydrolyzed protein.
- the nutritional composition may be supplemented with glutamine- containing peptides.
- the protein source of the nutritional composition comprises from about 40% to about 80% whey protein. In another embodiment, the protein source may comprise from about 20% to about 60% caseins.
- the amount of protein in a nutritional composition typically varies from about 1 to about 7 g/1 00 kcal.
- the nutritional composition comprises lactoferrin, which retains its stability and activity in the human gut against certain undesirable bacterial pathogens.
- the nutritional composition described herein can, in some embodiment
- lactoferrin also comprise non-human lactoferrin, non-human lactoferrin produced by a genetically modified organism and/or human lactoferrin produced by a genetically modified organism.
- Lactoferrin is generally described as an 80 kilodalton glycoprotein having a structure of two nearly identical lobes, both of which include iron binding sites.
- lactoferrin from different host species may vary in an amino acid sequence though commonly possesses a relatively high isoelectric point with positively charged amino acids at the end terminal region of the internal lobe.
- Lactoferrin has been recognized as having bactericidal and antimicrobial activities.
- the lactoferrin is bovine lactoferrin.
- lactoferrin maintain relevant activity even if exposed to a low pH (i.e., below about 7, and even as low as about 4.6 or lower) and/or high temperatures (i.e., above about 65°C, and as high as about 120°C, conditions which would be expected to destroy or severely limit the stability or activity of human lactoferrin or recombinant human lactoferrin.
- low pH and/or high temperature conditions can be expected during certain processing regimen for nutritional compositions of the types described herein, such as pasteurization.
- lactoferrin is present in the nutritional composition in an amount of from about 5 mg/100 kcal to about 16 mg/100 kcal.
- lactoferrin is present in an amount of about 9 mg/100 kcal to about 4 mg/100 kcal.
- the nutritional composition may comprise from about 2 mg to about 200 mg lactoferrin per 100 kcal.
- the nutritional composition may comprise between about 90 mg and about 148 mg lactoferrin per 100 kcal.
- the nutritional composition may also contain TGF- ⁇ .
- the level of TGF- ⁇ may be from about 0.0150 (pg ⁇ g) ppm to about 0.1000 (pg ⁇ g) ppm.
- the level of TGF- ⁇ in final composition including a stabilized probiotic is from about 0.0225 (pg/pg) ppm to about 0.0750 (pg/pg) ppm.
- the level of TGF- ⁇ is from about 2500 pg/mL to about 10,000 pg/mL, more preferably from about 3000 pg/mL to about 8000 pg/mL.
- the ratio of TGF- ⁇ : TGF ⁇ 2 is in the range of about 1 :1 to about 1 :20, or, more particularly, in the range of about 1 :5 to about 1 :15.
- the bioactivity of TGF- ⁇ in a nutritional composition is enhanced by the addition of a bioactive whey fraction.
- a bioactive whey fraction Any bioactive whey fraction known in the art may be used in such embodiments provided it achieves the intended result.
- this bioactive whey fraction may be a whey protein concentrate.
- the whey protein concentrate may be Salibra ® 800, available from Glanbia Nutritionals.
- the nutritional composition may comprise an amount of probiotic in addition to the stabilized probiotic.
- the resulting nutritional composition may include a total amount of probiotics effective to provide from about 1 x 10 4 to about 1 x 10 10 colony forming units (cfu) per kg body weight per day to a subject.
- the amount of the probiotic may vary from about 1 x 10 6 to about 1 x 10 9 cfu per kg body weight per day.
- the nutritional composition may include an amount of probiotics effective to provide about 1 x 10 6 cfu per kg body weight per day.
- the nutritional composition of the present disclosure comprises between about 1 x 10 6 cfu probiotic and about 1 x 10 10 cfu per 100 kcal of the composition.
- the amount of probiotic may be in the range of about 1 x 10 6 cfu to about 1 x 10 9 cf u per 100 kcal of the composition.
- the nutritional composition may include non-stabilized probiotics, with the final composition including some stabilized probiotics and some non-stabilized probiotics.
- the nutritional composition may further comprise at least one prebiotic.
- prebiotic refers to indigestible food ingredients that exert health benefits upon the host. Such health benefits may include, but are not limited to, selective stimulation of the growth and/or activity of one or a limited number of beneficial gut bacteria, stimulation of the growth and/or activity of ingested probiotic (stabilized or not) microorganisms, selective reduction in gut pathogens, and favorable influence on gut short chain fatty acid profile.
- Such prebiotics may be naturally-occurring, synthetic, or developed through the genetic manipulation of organisms and/or plants, whether such new source is now known or developed later.
- Prebiotics may include oligosaccharides, polysaccharides, and other prebiotics that contain fructose, xylose, soya, galactose, glucose and mannose. More specifically, prebiotics useful in the present disclosure may include lactulose, lactosucrose, raffinose, gluco-oligosaccharide, inulin, polydextrose, polydextrose powder, galacto- oligosaccharide, fructo-oligosaccharide, isomalto-oligosaccharide, soybean
- oligosaccharides lactosucrose, xylo-oligosaccharide, chito-oligosaccharide, manno- oligosaccharide, aribino-oligosaccharide, siallyl-oligosaccharide, fuco-oligosaccharide, and gentio-oligosaccharides, and combinations thereof.
- the total amount of prebiotics present in the nutritional composition may be from about 1.0 g/L to about 10.0 g/L of the composition (in the liquid form). In certain embodiments, the total amount of prebiotics present in the nutritional composition may be from about 2.0 g/L and about 8.0 g/L of the composition.
- the nutritional composition may comprise polydextrose (PDX). If polydextrose is used as a prebiotic, the amount of polydextrose in the nutritional composition may, in an embodiment, be within the range of from about 1.0 g/L to about 4.0 g/L.
- the amount of polydextrose in the nutritional product may, in an embodiment of the composition including stabilized probiotics, be within the range of from about 0.1 mg/100 kcal to about 0.5 mg/100 kcal. In another composition, the amount of polydextrose may be about 0.3 mg/100 kcal. At least 20% of the prebiotics should, in a preferred embodiment, comprise polydextrose (PDX).
- PDX polydextrose
- the nutritional composition comprises galacto- oligosaccharide.
- composition may be from about 0.2 mg/100 kcal to about 1.0 mg/100 kcal.
- amount of galacto-oligosaccharide in the nutritional composition may be from about 0.1 mg/100 kcal to about 0.5 mg/100 kcal.
- Galacto- oligosaccharide and polydextrose may also be supplemented into the nutritional composition in a total amount of about 0.6 mg/ 00 kcal.
- the nutritional composition comprises an additional carbohydrate source, that is, a carbohydrate source provided in addition to the other carbohydrates described throughout the present disclosure.
- additional carbohydrate sources can be any used in the art, e.g., lactose, glucose, fructose, corn syrup solids, maltodextrins, sucrose, starch, rice syrup solids, and the like.
- the amount of additional carbohydrate in the nutritional composition typically can vary from about 5 g and about 25 g/100 kcal. In some embodiments, the amount of carbohydrate is between about 6 g and about 22 g/100 kcal. In other combinations of additional carbohydrate source, that is, a carbohydrate source provided in addition to the other carbohydrates described throughout the present disclosure.
- Suitable additional carbohydrate sources can be any used in the art, e.g., lactose, glucose, fructose, corn syrup solids, maltodextrins, sucrose, starch, rice syrup solids, and the like.
- the amount of carbohydrate is between about 12 g and about 14 g/100 kcal.
- the nutritional composition may contain a source of long chain polyunsaturated fatty acids (LCPUFAs) which comprise docosahexaenoic acid (DHA).
- LCPUFAs long chain polyunsaturated fatty acids
- DHA docosahexaenoic acid
- suitable LCPUFAs include, but are not limited to, olinoleic acid, ⁇ -linoleic acid, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA) and arachidonic acid (ARA).
- the nutritional composition may be supplemented with both DHA and ARA, and the weight ratio of ARA:DHA may be from about 1 :3 to about 9:1. In certain embodiments the ARArDHA ratio is from about 1 :2 to about 4:1.
- the amount of long chain polyunsaturated fatty acids in the nutritional composition may vary from about 5 mg/100 kcal to about 100 mg/100 kcal, more preferably from about 10 mg/100 kcal to about 50 mg/100 kcal.
- a nutritional composition may be supplemented with oils containing DHA and ARA using standard techniques known in the art.
- the oils containing DHA and ARA may be added to a nutritional
- composition by replacing an equivalent amount of the rest of the overall fat blend normally present in the nutritional composition.
- the source of DHA and ARA may be any source known in the art such as marine oil, fish oil, single cell oil, egg yolk lipid, and brain lipid. In some compositions, the DHA and ARA are sourced from the single cell Martek oil,
- the DHA and ARA can be in natural form, provided that the remainder of the LCPUFA source does not result in any substantial deleterious effect on the infant. Alternatively, the DHA and ARA can be used in refined form.
- sources of DHA and DHA are identical to each other.
- ARA are single cell oils as taught in U.S. Patent Nos. 5,374,567; 5,550,156; and 5,397,591 , the disclosures of which are incorporated herein in their entirety by reference.
- the nutritional composition may be a milk- based nutritional composition that provides physiochemical and physiological benefits.
- bovine milk protein comprises two major
- casein precipitates and complexes with minerals forming semi-solid curds of varying size and firmness. Softer, smaller curds are easier for the body to digest than larger, harder curds. Curd formation may be an important consideration in the development of nutritional compositions, including, but not limited to infant formulas, medical foods, and premature infant formulas. As such, stabilized probiotics may be combined with compositions that include softer and smaller curds than standard infant formulas.
- vitamins and/or minerals may also be added in to the nutritional composition in amounts sufficient to supply the daily nutritional
- vitamin and mineral requirements will vary, for example, based on the age of the child. For instance, an infant may have different vitamin and mineral requirements than a child between the ages of one and thirteen years.
- the embodiments are not intended to limit the nutritional composition to a particular age group but, rather, to provide a range of acceptable vitamin and mineral components.
- the nutritional composition may optionally include, but is not limited to, one or more of the following vitamins or derivations thereof: vitamin Bi (thiamin, thiamin pyrophosphate, TPP, thiamin triphosphate, TTP, thiamin hydrochloride, thiamin mononitrate), vitamin B 2 (riboflavin, flavin mononucleotide, FMN, flavin adenine dinucleotide, FAD, lactoflavin, ovoflavin), vitamin B 3 (niacin, nicotinic acid, nicotinamide, niacinamide, nicotinamide adenine dinucleotide, NAD, nicotinic acid mononucleotide, NicMN, pyridine-3-carboxylic acid), vitamin B 3 -precursor
- vitamin B 6 pyridoxine, pyridoxal, pyridoxamine, pyridoxine
- pantothenic acid pantothenate, panthenol
- folate folic acid, folacin, pteroylglutamic acid
- vitamin B12 cobalamin, methylcobalamin
- vitamin C deoxyadenosylcobalamin, cyanocobalamin, hydroxycobalamin, adenosylcobalamin), biotin, vitamin C (ascorbic acid), vitamin A (retinol, retinyl acetate, retinyl palmitate, retinyl esters with other long-chain fatty acids, retinal, retinoic acid, retinol esters), vitamin D (calciferol, cholecalciferol, vitamin D 3 , 1 ,25,-dihydroxyvitamin D), vitamin E (a-tocopherol, a-tocopherol acetate, a-tocopherol succinate, a-tocopherol nicotinate, a-tocopherol), vitamin K (vitamin Ki, phylloquinone, naphthoquinone, vitamin K 2 , menaquinone-7, vitamin K3, menaquinone-4, menadione, menaquinone-8,
- menaquinone-8H menaquinone-9, menaquinone-9H, menaquinone-10,
- menaquinone-1 1 menaquinone-12, menaquinone-13
- choline inositol
- ⁇ -carotene any combinations thereof.
- the nutritional composition may optionally include, but is not limited to, one or more of the following minerals or derivations thereof: boron, calcium, calcium acetate, calcium gluconate, calcium chloride, calcium lactate, calcium phosphate, calcium sulfate, chloride, chromium, chromium chloride, chromium picolonate, copper, copper sulfate, copper gluconate, cupric sulfate, fluoride, iron, carbonyl iron, ferric iron, ferrous fumarate, ferric orthophosphate, iron trituration, polysaccharide iron, iodide, iodine, magnesium, magnesium carbonate, magnesium hydroxide, magnesium oxide, magnesium stearate, magnesium sulfate, manganese, molybdenum, phosphorus, potassium, potassium phosphate, potassium iodide, potassium chloride, potassium acetate, selenium, sulfur, sodium, docusate sodium, sodium chloride, sodium selenate
- the minerals can be added to nutritional compositions in the form of salts such as calcium phosphate, calcium glycerol phosphate, sodium citrate, potassium chloride, potassium phosphate, magnesium phosphate, ferrous sulfate, zinc sulfate, cupric sulfate, manganese sulfate, and sodium selenite. Additional vitamins and minerals can be added as known within the art.
- the nutritional composition of the present disclosure may optionally include one or more of the following flavoring agents, including, but not limited to, flavored extracts, volatile oils, cocoa or chocolate flavorings, peanut butter flavoring, cookie crumbs, vanilla or any commercially available flavoring.
- flavoring agents including, but not limited to, flavored extracts, volatile oils, cocoa or chocolate flavorings, peanut butter flavoring, cookie crumbs, vanilla or any commercially available flavoring.
- useful flavorings include, but are not limited to, pure anise extract, imitation banana extract, imitation cherry extract, chocolate extract, pure lemon extract, pure orange extract, pure peppermint extract, honey, imitation pineapple extract, imitation rum extract, imitation strawberry extract, or vanilla extract; or volatile oils, such as balm oil, bay oil, bergamot oil, cedarwood oil, cherry oil, cinnamon oil, clove oil, or peppermint oil; peanut butter, chocolate flavoring, vanilla cookie crumb, butterscotch, toffee, and mixtures thereof.
- the amounts of flavoring agent can vary greatly depending upon the flavoring agent used. The type and amount of flavoring agent can be selected as is known in the art.
- the nutritional composition of the present disclosure may optionally include one or more emulsifiers that may be added for stability of the final product.
- suitable emulsifiers include, but are not limited to, lecithin ⁇ e.g., from egg or soy), alpha lactalbumin and/or mono- and di-glycerides, and mixtures thereof.
- Other emulsifiers are readily apparent to the skilled artisan and selection of suitable emulsifier(s) will depend, in part, upon the formulation and final product.
- nutritional compositions of the present disclosure may comprise emulsifiers such as citric acid esters of mono- and/or diglycerides, diacetyl tartaric acid esters of mono- and/or diglycerides, and/or octenyl succinic anhydride modified starches.
- emulsifiers such as citric acid esters of mono- and/or diglycerides, diacetyl tartaric acid esters of mono- and/or diglycerides, and/or octenyl succinic anhydride modified starches.
- the nutritional composition of the present disclosure may optionally include one or more preservatives that may also be added to extend product shelf life.
- Suitable preservatives include, but are not limited to, potassium sorbate, sodium sorbate, potassium benzoate, sodium benzoate, calcium disodium EDTA, and mixtures thereof.
- the nutritional composition of the present disclosure may optionally include one or more stabilizers.
- Suitable stabilizers for use in practicing the nutritional composition of the present disclosure include, but are not limited to, gum arabic, gum ghatti, gum karaya, gum tragacanth, agar, furcellaran, guar gum, gellan gum, locust bean gum, pectin, low methoxyl pectin, gelatin, microcrystalline cellulose, CMC (sodium carboxymethylcellulose), methylcellulose hydroxypropyl methyl cellulose, hydroxypropyl cellulose, DATEM (diacetyl tartaric acid esters of mono- and diglycerides), dextran, carrageenans, and mixtures thereof.
- the nutritional composition of the present disclosure may further include at least one additional phytonutrient, that is, another phytonutrient component in addition to the pectin, starch or other phytonutrient components described herein.
- Phytonutrients, or their derivatives, conjugated forms or precursors, that are identified in human milk are preferred for inclusion in the nutritional composition.
- the nutritional composition of the present disclosure may comprise, in an 8 fl. oz. (236.6 mL) serving, between about 80 and about 300 mg anthocyanins, between about 100 and about 600 mg proanthocyanidins, between about 50 and about 500 mg flavan-3-ols, or any combination or mixture thereof.
- the nutritional composition comprises apple extract, grape seed extract, or a combination or mixture thereof.
- the at least one phytonutrient of the nutritional composition may be derived from any single or blend of fruit, grape seed and/or apple or tea extract(s).
- phytonutrients suitable for the nutritional composition include, but are not limited to, anthocyanins, proanthocyanidins, flavan- 3-ols (i.e.. catechins, epicatechins, etc.), flavanones, flavonoids, isoflavonoids, stilbenoids (i.e. resveratrol, etc.) proanthocyanidins, anthocyanins, resveratrol, quercetin, curcumin, and/or any mixture thereof, as well as any possible combination of phytonutrients in a purified or natural form. Certain components, especially plant- based components of the nutritional compositions may provide a source of phytonutrients.
- the phytonutrient component of the nutritional composition may also comprise naringenin, hesperetin, anthocyanins, quercetin, kaempferol, epicatechin, epigallocatechin, epicatechin-gallate, epigallocatechin-gallate or any combination thereof.
- the nutritional composition comprises between about 50 and about 2000 nmol/L epicatechin, between about 40 and about 2000 nmol/L epicatechin gallate, between about 100 and about 4000 nmol/L
- epigallocatechin gallate between about 50 and about 2000 nmol/L naringenin, between about 5 and about 500 nmol/L kaempferol, between about 40 and about 4000 nmol/L hesperetin, between about 25 and about 2000 nmol/L anthocyanins, between about 25 and about 500 nmol/L quercetin, or a mixture thereof.
- the nutritional composition may comprise the metabolite(s) of a phytonutrient or of its parent compound, or it may comprise other classes of dietary phytonutrients, such as glucosinolate or sulforaphane.
- the nutritional composition comprises carotenoids, such as lutein, zeaxanthin,
- the nutritional composition may also comprise isoflavonoids and/or isoflavones.
- Examples include, but are not limited to, genistein (genistin), daidzein (daidzin), glycitein, biochanin A, formononetin, coumestrol, irilone, orobol, pseudobaptigenin, anagyroidisoflavone A and B, calycosin, glycitein, irigenin, 5-0- methylgenistein, pratensein, prunetin, psi-tectorigenin, retusin, tectorigenin, iridin, ononin, puerarin, tectoridin, derrubone, luteone, wighteone, alpinumisoflavone, barbigerone, di-O-methylalpinumisoflavone, and 4'-methyl-alpinumisoflavone.
- Plant sources rich in isoflavonoids include, but are not limited to, soybeans, psoralea, kudzu, lupine
- the nutritional composition of the present disclosure comprises an effective amount of choline.
- An effective amount of choline is between about 20 mg choline per 8 fl. oz. (236.6 ml_) serving to about 100 mg per 8 fl. oz. (236.6 mL) serving.
- the disclosed nutritional composition may additionally comprise a source of ⁇ -glucan.
- Glucans are polysaccharides, specifically polymers of glucose, which are naturally occurring and may be found in cell walls of bacteria, yeast, fungi, and plants.
- Beta glucans ( ⁇ -glucans) are themselves a diverse subset of glucose polymers, which are made up of chains of glucose monomers linked together via beta-type glycosidic bonds to form complex carbohydrates.
- P-1 ,3-glucans are carbohydrate polymers purified from, for example, yeast, mushroom, bacteria, algae, or cereals.
- Stone BA Clarke AE. Chemistry and Biology of (1 -3)-Beta-Glucans. London:Portland Press Ltd; 1993.
- the chemical structure of P-1 ,3-glucan depends on the source of the ⁇ -1 ,3-glucan.
- various physiochemical parameters such as solubility, primary structure, molecular weight, and branching, play a role in biological activities of P-1 ,3-glucans.
- Yadomae T. Structure and biological activities of fungal beta-1 ,3-glucans. Yakugaku Zasshi. 2000;120:413-431.
- 3-1 ,3-glucans are naturally occurring polysaccharides, with or without ⁇ -
- Yeast-derived ⁇ -glucan is an insoluble, fiber-like, complex sugar having the general structure of a linear chain of glucose units with a ⁇ -1 ,3 backbone interspersed with ⁇ -1 ,6 side chains that are generally 6-8 glucose units in length.
- ⁇ -glucan derived from baker's yeast is poly-(1 ,6) ⁇ -D- glucopyranosyl-(1 ,3) ⁇ -D-glucopyranose.
- ⁇ -glucans are well tolerated and do not produce or cause excess gas, abdominal distension, bloating or diarrhea in pediatric subjects. Addition of ⁇ -glucan to a nutritional composition for a pediatric subject, such as an infant
- a growing-up milk or another children's nutritional product will improve the subject's immune response by increasing resistance against invading pathogens and therefore maintaining or improving overall health.
- the nutritional composition of the present disclosure may comprise ⁇ - glucan.
- the ⁇ -glucan is ⁇ -1 ,3;1 ,6 ⁇ 3 ⁇ .
- the ⁇ -1 ,3;1 ,6-glucan is derived from baker's yeast.
- composition may comprise whole glucan particle ⁇ -glucan, particulate ⁇ -glucan,
- microparticulate ⁇ -glucan comprises ⁇ -glucan particles having a diameter of less than 2 ⁇ .
- the nutritional composition is at between about 0.010 and about 0.080 g per 100g of the nutritional composition. In other embodiments, the nutritional composition comprises between about 10 and about 30 mg ⁇ -glucan per serving. In another embodiment, the
- the nutritional composition comprises between about 5 and about 30 mg ⁇ -glucan per 8 fl. oz. (236.6 mL) serving. In other embodiments, the nutritional composition
- ⁇ -glucan comprises an amount of ⁇ -glucan sufficient to provide between about 5 mg and
- the nutritional composition may be delivered in multiple doses to reach a target amount of ⁇ -glucan delivered to the subject throughout the day.
- the amount of ⁇ -glucan in the nutritional composition is between about 3 mg and about 17 mg per 100 kcal. In another embodiment the amount of ⁇ -glucan is between about 6 mg and about 17 mg per 100 kcal.
- the nutritional composition may be expelled directly into a subject's intestinal tract. In some embodiments, the nutritional composition is expelled directly into the gut. In some embodiments, the composition may be formulated to be consumed or administered enterally under the supervision of a physician and may be intended for the specific dietary management of a disease or condition, such as celiac disease and/or food allergy, for which distinctive nutritional requirements, based on recognized scientific principles, are established by medical evaluation.
- a disease or condition such as celiac disease and/or food allergy
- the nutritional composition of the present disclosure is not limited to compositions comprising nutrients specifically listed herein. Any nutrients may be delivered as part of the composition for the purpose of meeting nutritional needs and/or in order to optimize the nutritional status in a subject.
- the nutritional composition of the present disclosure may be any nutritional composition of the present disclosure.
- the nutritional composition of the present disclosure is a growing-up milk.
- Growing-up milks are fortified milk-based beverages intended for children over 1 year of age (typically from 1 -3 years of age, from 4-6 years of age or from 1 -6 years of age).
- Growing-up milks are designed with the intent to serve as a complement to a diverse diet to provide additional insurance that a child achieves continual, daily intake of all essential vitamins and minerals,
- macronutrients plus additional functional dietary components, such as non-essential nutrients that have purported health-promoting properties.
- compositions according to the present disclosure can vary from market-to-market, depending on local regulations and dietary intake information of the population of interest.
- nutritional compositions according to the disclosure include a milk protein source, such as whole or skim milk, plus added sugar and sweeteners to achieve desired sensory properties, and added vitamins and minerals.
- the fat composition is typically derived from the milk raw materials.
- Total protein can be targeted to match that of human milk, cow milk or a lower value.
- Total carbohydrate is usually targeted to provide as little added sugar, such as sucrose or fructose, as possible to achieve an acceptable taste.
- Vitamin A, calcium and Vitamin D are added at levels to match the nutrient contribution of regional cow milk. Otherwise, in some
- vitamins and minerals can be added at levels that provide nutrients
- nutrient values can vary between markets depending on the identified nutritional needs of the intended population, raw material
- the nutritional composition is hypoallergenic.
- the nutritional composition is kosher. In still further embodiments, the nutritional composition is a non-genetically modified product. In an embodiment, the nutritional formulation is sucrose-free. The nutritional composition may also be lactose-free. In other embodiments, the nutritional composition does not contain any medium-chain triglyceride oil. In some
- no carrageenan is present in the composition.
- the nutritional composition is free of all gums.
- stabilized probiotics having heretofore unrecognized stability are prepared.
- the stabilized bacterial mixture exhibits exceptionally high stability through the use of hydrolyzed mammalian protein, especially hydrolyzed mammalian protein with over 70% of the peptides having a molecular weight of less than 2,000 Daltons.
- the stabilized probiotics are uniquely effective for nutritional applications with intermediate moisture levels (such as water activity as high as 0.4) where increased shelf life and stability in hot and humid environments are desired.
- the stabilized probiotics may be packed separately or be combined with any of the embodiments of nutritional compositions described herein.
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US14/098,569 US20140093614A1 (en) | 2009-09-20 | 2013-12-06 | Probiotic stabilization |
PCT/US2014/064317 WO2015084532A1 (en) | 2009-09-20 | 2014-11-06 | Probiotic stabilization |
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EP3113631A1 true EP3113631A1 (de) | 2017-01-11 |
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EP14803016.6A Withdrawn EP3113631A1 (de) | 2013-12-06 | 2014-11-06 | Probiotische stabilisierung |
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EP (1) | EP3113631A1 (de) |
CN (1) | CN106028839A (de) |
AR (1) | AR098597A1 (de) |
AU (1) | AU2014357610B2 (de) |
CA (1) | CA2929170A1 (de) |
MX (1) | MX2016007006A (de) |
MY (1) | MY182613A (de) |
PH (1) | PH12016500690A1 (de) |
SG (1) | SG11201602869XA (de) |
TW (1) | TW201531235A (de) |
Cited By (1)
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CN118340808A (zh) * | 2024-06-14 | 2024-07-16 | 杭州天赋神奇生物科技有限责任公司 | 一种用亚麻籽欧米伽3宠物营养添加剂分离提取方法 |
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CN106923345B (zh) * | 2017-03-19 | 2021-02-26 | 北京罗诺强施医药技术研发中心有限公司 | 稳定的益生菌组合物 |
CN107495316A (zh) * | 2017-08-31 | 2017-12-22 | 烟台智本知识产权运营管理有限公司 | 一种食品稳定剂及其制备方法 |
CN113677212A (zh) * | 2019-03-28 | 2021-11-19 | 森永乳业株式会社 | 耐热性细菌组合物 |
CN114031650B (zh) * | 2021-11-29 | 2023-05-02 | 上海交通大学 | 壳寡糖硒配位化合物及其制备方法和应用 |
CN118415342B (zh) * | 2024-07-05 | 2024-10-01 | 浙江衡美健康科技股份有限公司 | 高效提高脂肪代谢的组合物及其制备方法和应用 |
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- 2014-11-06 CA CA2929170A patent/CA2929170A1/en not_active Abandoned
- 2014-11-06 CN CN201480066665.0A patent/CN106028839A/zh active Pending
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- 2014-11-06 MX MX2016007006A patent/MX2016007006A/es unknown
- 2014-11-06 EP EP14803016.6A patent/EP3113631A1/de not_active Withdrawn
- 2014-11-06 SG SG11201602869XA patent/SG11201602869XA/en unknown
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CA2929170A1 (en) | 2015-06-11 |
MX2016007006A (es) | 2016-09-07 |
CN106028839A (zh) | 2016-10-12 |
TW201531235A (zh) | 2015-08-16 |
AU2014357610B2 (en) | 2017-10-12 |
SG11201602869XA (en) | 2016-05-30 |
MY182613A (en) | 2021-01-27 |
PH12016500690A1 (en) | 2016-05-30 |
AU2014357610A1 (en) | 2016-05-12 |
AR098597A1 (es) | 2016-06-01 |
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