EP3111121B1 - Vanne d'échantillonnage rotative et dispositif équipé d'une telle vanne - Google Patents

Vanne d'échantillonnage rotative et dispositif équipé d'une telle vanne Download PDF

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Publication number
EP3111121B1
EP3111121B1 EP15712532.9A EP15712532A EP3111121B1 EP 3111121 B1 EP3111121 B1 EP 3111121B1 EP 15712532 A EP15712532 A EP 15712532A EP 3111121 B1 EP3111121 B1 EP 3111121B1
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EP
European Patent Office
Prior art keywords
orifices
parts
rotation
loops
external parts
Prior art date
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Application number
EP15712532.9A
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German (de)
English (en)
French (fr)
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EP3111121A1 (fr
Inventor
Nathalie HENON
Florent Beauducel
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Horiba ABX SAS
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Horiba ABX SAS
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/567—Valves, taps or stop-cocks
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
    • F16K11/02—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit
    • F16K11/06—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements
    • F16K11/072—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members
    • F16K11/074—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members with flat sealing faces
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
    • F16K11/10—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with two or more closure members not moving as a unit
    • F16K11/14—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with two or more closure members not moving as a unit operated by one actuating member, e.g. a handle
    • F16K11/16—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with two or more closure members not moving as a unit operated by one actuating member, e.g. a handle which only slides, or only turns, or only swings in one plane
    • F16K11/163—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with two or more closure members not moving as a unit operated by one actuating member, e.g. a handle which only slides, or only turns, or only swings in one plane only turns
    • F16K11/166—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with two or more closure members not moving as a unit operated by one actuating member, e.g. a handle which only slides, or only turns, or only swings in one plane only turns with the rotating spindles at right angles to the closure members
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0622—Valves, specific forms thereof distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves

Definitions

  • the present invention relates to a sampling valve and to a device equipped with such a valve, for example, but not limited to a device for carrying out hematological and / or biochemical measurements from a biological sample.
  • Carrying out hematological and / or biochemical measurements in machines requires sampling the biological sample, for example the blood sample taken from patients. Sampling is used to calibrate volumes of blood, called aliquots. These aliquots are then mixed with different reagents to reveal constituents of the blood during the analyzes. The blood volumes must be calibrated precisely and repeatably in order to secure the measurements.
  • a sampling valve can operate in isolation or be integrated into an analysis machine.
  • Automated analysis machines equipped with such valves allow operation at high rates, for example of the order of one measurement per minute.
  • Known sampling valves typically allow a biological sample to be split into loops arranged on fixed external parts relative to an internal part that is movable in rotation. Examples include documents WO 90/07702 A1 , WO 2004/034034 A1 , FR 2924804 A1 , or US 4,948,565 .
  • blood volumes are calibrated either in loops or in chambers located in a room.
  • Mixtures of blood aliquots with reagents are typically transferred to outlet channels by flowing through holes and grooves formed in a room.
  • the rotary drive of rotating parts is typically carried out with a stepping motor or a screw transmission with a stop without solid stop which presents a risk of loss of positioning of the relative angular position of the parts.
  • valve parts are clamped against each other for their mutual sealing.
  • the unilateral rotation of the internal part is accompanied by a significant unbalanced force on the stop which degrades over time. This contributes to the risk of adjustment.
  • the main object of the present invention is to overcome all or part of the drawbacks of the sampling valves of the prior art.
  • Another object of the present invention is to provide a sampling valve simultaneously producing micro-aliquots having different volumes.
  • Yet another object of the present invention is to provide a sampling valve with rotary elements making it possible to simplify the networks of loops, channels and capillaries.
  • the present invention also aims to provide a sampling valve allowing uniform and reproducible tightening of its elements.
  • Another object of the present invention is to provide a sampling valve distributing the rotational forces of its elements.
  • Another object of the present invention is to propose a sampling valve preventing any loss of positioning.
  • the rotation of two external parts has the advantage of distributing the mechanical forces applied to the parts of the valve.
  • a simultaneous actuation of the external parts in an opposite direction of rotation substantially cancels the torques undergone by the internal part.
  • Such mechanical distribution also has the advantage of optimizing the tightness of the valve.
  • the rotation of two external parts makes it possible to simplify the networks of loops, channels and orifices of the valve, for example by reducing the number of loops and orifices, while making it possible to increase the number of configurations. functional possibilities.
  • the fluids e.g. blood aliquots, reagents
  • a linear actuator such as a pneumatic piston and in embodiments in which a plurality of angular positions of these rotary parts are produced by a mechanical stop makes it possible to avoid any risk of loss of positioning while allowing the use of a single actuator.
  • the parts are in abutment with respect to one another as regards their relative angular position.
  • valve of the specified type will denote a sampling valve comprising two external parts, an internal part enclosed between said external parts, and means for adjusting the relative angular position of said parts around an axis of rotation.
  • said internal part having opposite surfaces pressed in a sealed and sliding manner on adjacent surfaces of said external parts, said external parts comprising orifices, loops and channels, said loops and said channels being arranged to communicate selectively with orifices passing through said internal part.
  • a valve of the specified type in particular but not limitatively in accordance with the first aspect, in which a relative rotation of the parts from a functional state of sampling isolates calibrated volumes of liquid sampled then when a dispensing functional state is reached places these calibrated volumes in conjunction with dispensing circuits, the valve is characterized in that some of said calibrated volumes are defined in one or more loops and calibrated by the capacity of said one or more loops and other calibrated volumes are defined in one or more orifices of the internal part and calibrated by the capacity of said one or more orifices of said internal part.
  • the aliquots can be formed either in the loops or in the chambers produced by orifices in the internal part, either in these loops and in these bedrooms.
  • the volumes thus formed can thus meet different calibration criteria depending on the type of analysis to be performed. This therefore makes it possible to combine analyzes using, for example, volumes coming from the loops and micro-volumes coming from rooms. Such an embodiment also makes it possible to optimize the consumption of diluent and reagents.
  • a valve produced according to such an embodiment makes it possible to dispense with communication grooves between the loops, which limits the risks of clogging and fouling.
  • a valve according to this second embodiment according to the third aspect of the invention makes it possible to keep at least one emergency loop and / or at least one emergency room in the internal room making it possible to carry out an additional verification measure without re-sampling.
  • This advantage is particularly relevant when the sampling valve is for example included in an analysis machine allowing high sampling rates.
  • the orifices, the loops and the channels of the external parts, and the orifices passing through the internal part are arranged to define by their relative angular positions a fourth functional state, namely , in addition to the three functional states of the second embodiment, a secondary sampling or secondary rinsing state in which several of said loops, some of which are common with said loops of said primary sampling state, are connected, by several of said orifices of said internal part and several of said orifices of said external parts, to at least one inlet channel and to at least one outlet channel.
  • a valve according to this third embodiment according to the third aspect of the invention makes it possible to constitute two sampling circuits operating in parallel within the same valve.
  • sampling valve is for example included in an analysis machine allowing high sampling rates.
  • At least one of said exemption states also directly links at least one of the orifices of the internal part, via orifices of the external parts, to at least one inlet channel and to at least one outlet channel, said at least one of said orifices of said internal part being a volume sampling chamber calibrated.
  • the valve according to the invention makes it possible to get rid of any groove or hollow formed in one or more parts of the valve. This avoids creating turbulence zones and consequently prevents fouling and clogging of the valve.
  • a sampling valve is very sensitive to disturbances in the fluid flows flowing there.
  • the absence of turbulence zones is essential in order not to cause false results when using the valve.
  • the valve does not contain any zone of turbulence such as recesses (or baffles for aliquot return in the opposite direction) in the channels in which typically circulates lysed blood (burst cells) because proteins contained in this lysed blood cling to the corners and can be deposited definitively, causing for example fouling or salting out of particles foreign to the content of aliquots.
  • a sampling valve is also very sensitive to variations in the diameter of the internal channels (pressure drop). It is thus necessary to avoid any variation in diameter as produced by hollows (aliquot deflection baffles) in the channels in which the reagents circulate because a phenomenon of degassing of the reagent occurs in the areas of depression, which leads to formation microbubbles (eg blank count of ghost cells).
  • the sampling valve according to the invention makes it possible to meet these constraints.
  • the direction of circulation of the fluid (s) circulating in the valve are always traversing (ie no "U-turn" by means of recesses), in particular at the level of the internal part.
  • the fluid or fluids circulating or being contained in the internal part of the valve circulate or are contained in orifices passing through this internal part, these orifices preferably being cylindrical orifices, and being preferably perpendicular to said opposite surfaces pressed in a sealed manner and slippery on the adjacent surfaces of the external parts.
  • the valve according to the invention makes it possible to satisfy such technical constraints, by making micro-holes in the internal part and by dimensioning this internal part giving it a small thickness, for example of the order of a few millimeters, the thickness of the internal part being preferably less than 3 mm, preferably less than 2.5 mm.
  • the internal part is substantially cylindrical and its diameter is less than 40 mm, preferably less than 30 mm.
  • the volume constituted by said micro-holes is less than 1 ⁇ l, preferably less than 0.5 ⁇ l.
  • the thickness of the external parts is less than 6 mm, preferably less than 4.5 mm.
  • the external parts are substantially cylindrical and their diameter is less than 45 mm, preferably less than 35 mm.
  • sampling loops have an inside diameter of less than 2 mm, preferably less than 1 mm.
  • the volume constituted by at least part of the sampling loops is less than 35 ⁇ l, preferably less than 25 ⁇ l.
  • the sampling loops are typically produced with metal tubes, the plastic tubes not being suitable.
  • human blood and at least four different reagents having different properties, typically detrimental both for the blood samples, for the other reagents are used simultaneously / or for the sampling valve. All distributions are done simultaneously. In particular, all the volumes of blood are withdrawn at one time, that is to say in a single relative position of the moving parts corresponding to the withdrawal state. In another position, a calibration, distribution and mixing step of these blood aliquots is then carried out with the appropriate volume of each of the respective reagents.
  • Sampling and distribution are carried out in a very short time, of the order of a second and it is important that the positioning of the parts of the valve is precise (of the order of a micron) and repeatable.
  • to limit maintenance operations and increase the service life of the valve limitation of the risks of loss of power and failure, it is necessary to reach the different relative positions of the moving parts as simply as possible.
  • valve according to the invention makes it possible to respond advantageously to such constraints, in particular by the use of a linear actuator, associated with a stirrup which drives each external part at the same time and in opposite direction around a single axis of rotation, or also by the presence of a single spring to achieve uniform support of the parts of the valve against one another, or also by the single and robust positioning stop limiting positioning losses.
  • the parts of the valve include ceramic. Ceramic makes the valve neutral from a thermal point of view and chemical to avoid corrosion or pollution by salting out of particles. The ceramic also makes it possible to ensure good flatness of the parts on the surfaces bringing two given parts into contact with one another, and a very low roughness.
  • the invention also relates to a device for analyzing biological parameters using at least one sampling valve according to the first or second aspect of the invention and in each of the embodiments which have just been described.
  • the sampling valve 1 shown in figures 1 to 4 includes a sampling assembly 2, an actuator 3 and a support 4.
  • the sampling assembly 2 comprises two parts 21, 22 movable in rotation about a common axis A, called rotary parts, relative to a fixed part 23 relative to the support 4.
  • the rotary parts 21 , 22 and fixed 23 have a general shape of discs. They are stacked along the axis A and are in two-by-two contact on their mutual contact faces 211, 221, 231, 232 planar and perpendicular to the axis A.
  • the rotating parts are the two external parts 21 and 22, placed on either side of the internal part 23.
  • the internal part 23 is crossed by orifices 233 connecting together the contact surfaces 231, 232.
  • the external parts 21, 22 carry sampling loops 219, 229 and dispensing and evacuation channels 218, 228 fixed on their external face 212, 222.
  • the loops 219, 229 each have two ends which open out through the contact face 211, 221 on at least two orifices 233 of the internal part 23.
  • the channels 218, 228 each have two ends, one of which opens through the contact face 211, 221 on at least one orifice 233 of the part internal 23.
  • the external parts 21, 22 and internal 23 of the sampling assembly 2 include a central opening 214, 224, 234 making it possible to accommodate a clamping system 5, for example with a spring.
  • the clamping system 5 makes it possible to carry out a calibrated central clamping of the external parts 21, 22 and internal 23 along the axis A of rotation of the external parts 21, 22.
  • This clamping causes sufficient pressure to prevail between the contact faces to seal the contact between the contact faces 211, 231 and 221, 232, in the sense that the withdrawn fluid or the analysis fluid cannot infiltrate in significant quantities between the contact faces.
  • the contact faces have a sufficiently low roughness to allow relative sliding between the contact faces for mutual rotation of the parts. This low roughness is favorable to the desired seal.
  • the external parts 21, 22 of the sampling assembly 2 also include an eccentric opening 215, 225, made circular in this embodiment.
  • the internal part 23 also comprises an eccentric opening 235, for example of oblong shape in a first radial direction R1 of the sampling assembly 2.
  • a shaft 6 of cylindrical shape and of diameter substantially identical to the smallest width of the eccentric opening 235 of the internal part 23 passes through the eccentric openings 215, 225, 235 of the external parts 21, 22 and internal 23.
  • the eccentric openings 215, 225 have around the axis A a circumferential dimension greater than the diameter of the shaft 6, for example but in a non-restrictive manner by a factor of 2, so that the shaft can be in contact only on one edge of the housing formed by each of the eccentric orifices 215, 225 of the external parts 21, 22.
  • the shaft 6 is fixed relative to the fixed support 4.
  • Such an assembly allows, when the external parts 21, 22 and internal 23 are brought into contact and tightened by the clamping system 5, to immobilize in rotation the internal part 23 relative to the support 4 by the shaft 6, this due to of the diameter of the shaft 6 substantially identical to the width of the eccentric opening 235 of the internal part 23.
  • the movement of the external parts 21, 22 around the axis of rotation A is limited in each of two directions of rotation S1, S2 (part 22) or S1 ', S2' (part 21) by the shaft 6 which comes into abutment with the housing of the eccentric orifices 215, 225.
  • the three parts 21, 22, 23 are in abutment on the same reference surface constituted by the side wall of the shaft 6.
  • this configuration is particularly advantageous for positioning the rotating parts 21, 22 in a reproducible relative angular position.
  • the actuator 3 is a linear actuator comprising a piston 31 displaced in translation in a radial direction relative to the axis of rotation A, here the radial direction R1. In the example, this direction is vertical.
  • the actuator is placed below the parts 21, 22, 23.
  • the piston 31 is integral with an actuating stirrup comprising two arms 32, 33 whose ends are engaged with notches 216, 226 formed in the sides 217, 227 of the rotating parts 21, 22.
  • the sides 217, 227 are located on either side of the actuation direction of the actuator 3.
  • the displacement of the piston 31 and the caliper 32, 33 towards the sampling assembly 2 (towards the top of the figure) produces a displacement in rotation along the axis A in a first direction S1 of the external part 22 and in a second direction S2 ′, opposite to the first direction S1, of the external part 21.
  • the displacement of the piston 31 and the caliper 32, 33 in the direction opposite to that of the sampling assembly 2 produces a displacement in rotation along the axis A in the first direction S1 'of the external part 21 and in the second direction S2' of the external part 22.
  • This embodiment has the advantage of distributing the rotational forces over the external parts 21, 22, which makes it possible to reduce the risks of jamming.
  • this embodiment enables the two external parts 21, 22 to be actuated by a single actuator 3 operating with a simple piston 31 displaced in translation, which reduces both the size and the manufacturing costs and facilitates the manufacturing and maintenance stages.
  • This embodiment is also particularly advantageous in that in each of the two functional states the three parts 21, 22, 23 are supported in abutment on the shaft 6, in other words on a common reference surface, which avoids the risks of loss of positioning of the external parts 21, 22.
  • FIGS. 5 to 7 illustrate the operation of the sampling valve in different functional states.
  • parts 21, 22, 23 are unrolled so that their relative angular position is visible in the form of a relative portion in the vertical direction.
  • each part is subdivided in the circumferential direction (vertical to the Figures 5 to 7 ) in small elementary rectangles making it possible to view the relative angular position of the parts 21, 22, 23 schematically.
  • the embodiment of the figure 5 comprises two distinct functional states: (1) a state of withdrawal Ep or rinsing Er, as well as (2) a state of exemption Ed.
  • the state of sampling Ep or of rinsing Er is one and the same state because the relative angular position of the parts 21, 22, 23 is identical.
  • the parts 21, 22, 23 are shown in an angular position called the reference illustrated by an alignment of the parts 21, 22, 23.
  • the state of withdrawal Ep and the state of rinsing Er are shown separately so to illustrate two possible uses of this functional state.
  • a liquid for example a blood sample, is injected into an inlet channel ce1 and flows to an outlet channel cs1 through loops b and orifices 22o1, 22o1, 22o3 parts 21, 22, 23 which are all in series with each other to form a continuous and unbranched conduit between the channels ce1 and cs1.
  • another liquid for example a diluent, is injected into the same inlet channel and circulates in the same orifices and loops up to the outlet channel for cleaning these orifices and loops.
  • the liquid injected invades the entire continuous duct formed between the ce1 and cs1 channels.
  • the state of exemption Ed shown on the figure 5 is a second functional state of the sampling valve according to the invention. This state is typically used to constitute aliquots of blood and to dispense these aliquots with different reagents in order to carry out analyzes on the blood sample taken.
  • the relative rotary positioning of the external parts 21, 22 makes it possible to constitute aliquots of the liquid withdrawn in several or all the loops b, called the sampling loops, as well as in orifices 23o3 of the part 23, called the sampling chambers.
  • reagents are inserted into entry channels ce2, so as to push the aliquots by circulating in orifices 21o2, 22o2, 23o2 aligned with the pieces 21, 22, 23 up to cs2 output channels.
  • one or more reagents are inserted in one or more inlet channels ce3, so as to circulate in one or more orifices 21o3 and 22o3 aligned with the one or more 23o3 sampling chambers up to one or more cs3 output channels.
  • the valve has the advantage of allowing sampling using either these two types of calibration, or only one at a time.
  • the embodiment which has just been described is notably compatible with the characteristic of relative angular positioning of the external parts 21, 22 defined by stop means 6 of the first aspect of the invention.
  • the state of sampling Ep and of rinsing Er can be obtained by the state of the valve 1 shown in figure 3 while the state of exemption Ed can be obtained by the state of the valve 1 represented in figure 4 (see above for the description of these figures).
  • the embodiment of the figure 6 comprises three distinct functional states: (1) a state of withdrawal Ep 'or of rinsing Er', (2) a state of primary exemption Ed1 ', as well as (3) a state of secondary exemption Ed2'.
  • a special feature of this embodiment concerns the existence of two exemption states Ed1 ', Ed2'. These exemption states Ed1 ', Ed2' are based on the same operating principle as the exemption state Ed of the previous embodiment (see above). This embodiment however provides two independent dispensing networks each having their own loops b1 ', b2' and / or sampling chambers 23o3 '.
  • each of the two exemption states Ed1 ', Ed2' is associated with a relative angular position of the external parts 21, 22 obtained by a displacement of different magnitude for each of these parts 21, 22.
  • the parts 21, 22 are moved in the opposite direction with respect to the withdrawal state Ep' and the extent of this movement is displayed by the height of a small rectangle for the part 21 and two small rectangles for room 22.
  • the rotary part 21 is moved so as to find the reference position of the state of withdrawal Ep ′, that is to say a value of a small rectangle on the figure 6 compared to the state of primary exemption Ed1 '.
  • the rotary part 22 is not displaced relative to the state of primary dispensation Ed1'.
  • the configuration which has just been described makes it possible to use, in the state of secondary exemption Ed2 ', one or more sampling loops b2' and orifices 21o2b ', 22o2b', 23o2b 'and channels ce2b', cs2b ' correspondents, and / or one or more sampling chambers and corresponding orifices and channels not used in the state of primary exemption Ed1 '.
  • this configuration makes it possible to use, in the state of primary exemption Ed1 ', one or more sampling loops b1' and orifices 21o2a ', 22o2a', 23o2a 'and corresponding ce2a', cs2a 'channels, and / or one or more sampling chambers 23o3 'and orifices 21o3', 22o3 'and corresponding ce3', cs3 'channels not used in the state of secondary exemption Ed2'.
  • the embodiment of the figure 7 comprises four distinct functional states: (1) a state of primary sampling Ep1 "or primary rinsing Er1", (2) a state of secondary sampling Ep2 “or secondary rinsing Er2", (3) a state of primary exemption Ed1 " , as well as (4) a state of secondary exemption Ed2 ".
  • This embodiment is based on several principles similar to the two embodiments which have just been described. In particular, it provides two exemption states Ed1 ", Ed2" for which reference may be made to the description of the exemption states Ed1 ', Ed2' of the previous embodiment.
  • a feature of this embodiment concerns the existence of a second state of sampling Ep2 "or rinsing Er2", parallel to the first state of sampling Ep1 "or rinsing Er1".
  • one or more of the loops b1 ", b2" and one or more orifices 23o1 “, 23o2" are different between the two withdrawal states Ep1 ", Ep2".
  • a rinsing will typically be carried out in the primary rinsing state Er1 "between the first sampling carried out in the primary sampling state Ep1" and the second sampling carried out in the secondary sampling state Ep2 ".
  • the sampling valve 1 comprises the two external parts 21, 22, the internal part 23 sandwiched between said external parts 21, 22, and the means 3 for adjusting the relative angular position of said parts 21, 22, 23 around the axis of rotation A, said internal part 23 having opposite surfaces 231, 232 pressed in a sealed and sliding manner on adjacent surfaces 211, 221 of said external parts 21, 22, said external parts 21, 22 comprising orifices 213, loops 219, 229 and channels 218, 228, said loops 219, 229 and said channels 218, 228 being arranged to selectively communicate with orifices 233 passing through said internal part 23.
  • Two 21, 22 of said parts 21, 22, 23 are rotatable around of said axis of rotation A relative to one 23 of said parts 21, 22, 23 which is fixed.
  • An inter-orifice distance is defined as being, for all the orifices 213, 223, 233, the minimum distance between the contours of two of these orifices 213, 223, 233 on a given part 21, 22, 23.
  • the orifices 213, 223, 233 of a given part 21, 22, 23 are spaced apart from each other (on an opposite or adjacent surface of the part 21, 22, 23) at least by the inter-orifice distance .
  • each orifice 213, 223, 233 of a given piece 21, 22, 23 is spaced (on an opposite or adjacent surface of the piece 21, 22, 23) from the edge of the part 21, 22, 23 in which it is made at least from an orifice-edge distance.
  • a sealing distance "d" is defined such that the inter-orifice distance is preferably greater than twice this sealing distance and such that the orifice-edge distance is preferably greater than this sealing distance (see figure 8 ).
  • the sealing distance is determined according to the perimeter (or diameter) of an orifice to be isolated as well as the pressure applied to this orifice by the fluid it contains. This sealing distance is preferably greater than 2 mm, preferably greater than 2.4 mm. These ranges of values for the sealing distance in particular ensure good sealing of the valve for a fluid pressure in the valve of approximately 1.5 bars and a diameter of the orifices less than 0.5 mm.
  • the sealing distance "d” is represented in figure 8 by the diameter of a fictitious circle CF.
  • the figure 8 is a partial view of the internal part 23 on which two orifices 233a, 233b are represented. Three fictitious circles CF are placed tangentially to these orifices 233a, 233b indicating that said inter-orifice distance and said orifice-edge distance (this edge of the part 23 bearing the reference 237) is greater than the sealing distance, c '' i.e. the diameter of the fictitious circle CF.
  • Such a characteristic makes it possible to isolate each channel, in particular when the position of the rotating parts 21, 22 is changed, for example from a sampling position to a dispensing position.
  • the sealing distance makes it possible to avoid leakage of liquid, both in a given position of the rotating parts 21, 22 and when these rotating parts 21, 22 are rotated.
  • valve according to the invention makes it possible to ensure proper operation without making grooves or hollows (or aliquot return baffles).
  • the presence of hollows involves rinsing them in each of the states described above.
  • the absence of a recess makes it possible, on the contrary, to carry out the rinsing in one and only one of these states, and consequently to simplify the hydraulic circuit. Rinsing can be carried out in the position of the valve parts corresponding to the withdrawal state.
  • the valve according to the invention also makes it possible to carry out the rinsing exhaustively and in a precise order ranging from the least corrosive reagent to the most corrosive reagent.

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  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hydrology & Water Resources (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
EP15712532.9A 2014-02-28 2015-02-20 Vanne d'échantillonnage rotative et dispositif équipé d'une telle vanne Active EP3111121B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1451635A FR3018116B1 (fr) 2014-02-28 2014-02-28 Vanne d'echantillonnage rotative et dispositif equipe d'une telle vanne
PCT/EP2015/053632 WO2015128262A1 (fr) 2014-02-28 2015-02-20 Vanne d'échantillonnage rotative et dispositif équipé d'une telle vanne

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EP3111121A1 EP3111121A1 (fr) 2017-01-04
EP3111121B1 true EP3111121B1 (fr) 2020-06-24

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EP15712532.9A Active EP3111121B1 (fr) 2014-02-28 2015-02-20 Vanne d'échantillonnage rotative et dispositif équipé d'une telle vanne

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US (1) US10150119B2 (ja)
EP (1) EP3111121B1 (ja)
JP (1) JP6463380B2 (ja)
CN (1) CN106102913B (ja)
FR (1) FR3018116B1 (ja)
WO (1) WO2015128262A1 (ja)

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DE102015009046A1 (de) * 2015-07-13 2017-01-19 Dürr Systems Ag Beschichtungsmittelventil
EP3244214B1 (en) * 2016-05-11 2019-11-06 Diatron MI Zrt. Device to sample liquids with high-precision in an automated sample analyzer
CN110108533B (zh) * 2019-05-24 2023-10-24 常州派斯杰医疗设备有限公司 组织脱水机
CN111665090B (zh) * 2020-07-08 2023-05-12 南京美世特自动化工程有限公司 一种用于pH计的热电脱硫吸收塔浆液取样器
CN112657565B (zh) * 2020-12-17 2022-08-19 京东方科技集团股份有限公司 微流控通道及其控制方法、微流控芯片和分析装置

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JPH0119057Y2 (ja) * 1980-11-07 1989-06-02
US4726237A (en) * 1985-06-19 1988-02-23 Sequoia-Turner Corporation Fluid metering apparatus and method
US4957008A (en) 1988-12-28 1990-09-18 Coulter Electronics, Inc. Fluid sampling and transfer valve assembly
US4948565A (en) 1989-04-25 1990-08-14 Fisher Scientific Company Analytical system
US5089234A (en) * 1989-08-09 1992-02-18 Serono-Baker Diagnostics, Inc. Controlled environment liquid diluting and transfer valve assembly
US6662826B1 (en) 2002-10-07 2003-12-16 Abbott Laboratories Liquid metering and transfer valve assembly with port switch
FR2924804B1 (fr) * 2007-12-07 2012-03-02 Horiba Abx Sas Vanne d'echantillonnage multi-positions.
AT511185B1 (de) * 2011-03-02 2013-10-15 Argos Zyklotron Betr S Gesmbh Ventil und verwendung des ventils

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Publication number Publication date
WO2015128262A1 (fr) 2015-09-03
US10150119B2 (en) 2018-12-11
CN106102913B (zh) 2019-07-05
JP6463380B2 (ja) 2019-01-30
US20160361718A1 (en) 2016-12-15
FR3018116B1 (fr) 2017-06-16
FR3018116A1 (fr) 2015-09-04
CN106102913A (zh) 2016-11-09
JP2017512313A (ja) 2017-05-18
EP3111121A1 (fr) 2017-01-04

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