EP3082707A1 - Protective cap for a dispenser, and dispenser for discharging pharmaceutical and/or cosmetic liquids - Google Patents

Protective cap for a dispenser, and dispenser for discharging pharmaceutical and/or cosmetic liquids

Info

Publication number
EP3082707A1
EP3082707A1 EP14802906.9A EP14802906A EP3082707A1 EP 3082707 A1 EP3082707 A1 EP 3082707A1 EP 14802906 A EP14802906 A EP 14802906A EP 3082707 A1 EP3082707 A1 EP 3082707A1
Authority
EP
European Patent Office
Prior art keywords
protective cap
dispenser
sterile filter
opening
outlet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP14802906.9A
Other languages
German (de)
French (fr)
Other versions
EP3082707B1 (en
Inventor
Matthias Wochele
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aptar Radolfzell GmbH
Original Assignee
Aptar Radolfzell GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51982577&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP3082707(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aptar Radolfzell GmbH filed Critical Aptar Radolfzell GmbH
Publication of EP3082707A1 publication Critical patent/EP3082707A1/en
Application granted granted Critical
Publication of EP3082707B1 publication Critical patent/EP3082707B1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/16—Closures not otherwise provided for with means for venting air or gas
    • B65D51/1605—Closures not otherwise provided for with means for venting air or gas whereby the interior of the container is maintained in permanent gaseous communication with the exterior
    • B65D51/1616—Closures not otherwise provided for with means for venting air or gas whereby the interior of the container is maintained in permanent gaseous communication with the exterior by means of a filter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/145—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using air filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
    • B65D47/2056—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type
    • B65D47/2062—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type in which the deformation raises or lowers the valve stem
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/20—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge
    • B65D47/2018—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure
    • B65D47/2056—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type
    • B65D47/2062—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type in which the deformation raises or lowers the valve stem
    • B65D47/2068—Closures with discharging devices other than pumps comprising hand-operated members for controlling discharge comprising a valve or like element which is opened or closed by deformation of the container or closure lift valve type in which the deformation raises or lowers the valve stem in which the stem is lowered by the pressure of the contents and thereby opening the valve
    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes

Definitions

  • the invention relates to a protective cap for a dispenser and a dispenser for dispensing pharmaceutical and / or cosmetic liquids.
  • a dispenser comprises a liquid reservoir and an outlet opening through which the liquid can be discharged into a surrounding atmosphere.
  • the liquid reservoir liquid will be promoted for discharge in the direction of the outlet opening, which can be done via many different mechanisms.
  • the liquid reservoir may be formed as a squeeze bottle, the content of which can be pressurized by deformation of the walls. Also, a separate pumping device is used.
  • the dispenser comprises an outlet channel connecting the liquid reservoir to the outlet opening and a pressure-dependent opening or manually operable outlet valve arranged in the outlet channel, the outlet valve closing the outlet channel in the closed state.
  • the outlet valve divides the outlet channel into a first partial section and a second partial section, wherein the second partial section extends adjacent to the outlet opening in the direction of the liquid reservoir.
  • the second portion corresponds to a drop formation surface at the exit opening.
  • the exhaust valve results in that after closing it no liquid, which has passed into a portion of the outlet channel on a side facing away from the liquid reservoir side of the outlet valve or which is left in the vicinity of the outlet opening outside the outlet channel, sucked back into the dispenser can be. A possible contamination of the contents of the liquid reservoir by liquid residues that have been sucked back is thereby prevented. The residual liquid therefore remains in an externally accessible area. Upon contact with the atmosphere, the residual liquid dries quickly.
  • the object of the invention is to provide a protective cap for a dispenser, which allows rapid drying and in which the problem of penetration of microorganisms is mitigated into the protective cap.
  • the object of the invention is further to provide a dispenser with a corresponding protective cap available.
  • a protective cap for a dispenser for dispensing pharmaceutical and / or cosmetic liquids having a liquid reservoir and an outlet opening through which the liquid can be dispensed into a surrounding atmosphere, and wherein the protective cap is at least a ventilation opening for communicating an interior space with an external environment, and on the protective cap a sterile filter covering the at least one ventilation opening is arranged in order to reduce or prevent germ introduction via the at least one ventilation opening into the interior of the protective cap.
  • a dispensing apparatus comprising a dispenser for dispensing pharmaceutical and / or cosmetic liquids having a liquid reservoir and an outlet opening through which the liquid can be dispensed into a surrounding atmosphere, and a protective cap having at least one ventilation opening for Communicating an interior with an external environment wherein a sterile filter covering the at least one ventilation opening is arranged on the protective cap in order to reduce or prevent germ introduction via the at least one ventilation opening into the interior of the protective cap.
  • germ introduction into an interior of the protective cap via the at least one ventilation opening is prevented or at least reduced.
  • germs or microorganisms in the context of the present invention are meant all microbial pathogens, in particular bacteria and viruses.
  • the dispenser is particularly suitable for unpreserved ophthalmics.
  • the dispenser comprises an outlet channel which connects the liquid reservoir to the outlet opening, and a pressure-dependent opening or manually operable outlet valve which is arranged in the outlet channel and which closes the outlet channel in a closed state.
  • the outlet valve prevents penetration of germs into the liquid reservoir.
  • the outlet valve is preferably a pressure-dependent opening outlet valve, which is opened by pressurizing the liquid in the liquid reservoir or a partial charge removed therefrom and automatically closes again as soon as the corresponding overpressure relative to the environment is eliminated. In principle, however, other types of valves can be used here.
  • the liquid in the liquid reservoir is permanently under pressure and the handling of the dispenser via a handle, whose manual operation opens the outlet valve.
  • the outlet valve prevents a sucked back liquid in the liquid reservoir.
  • the at least one ventilation opening causes a rapid drying of this residual liquid.
  • the sterile filter preferably has an average pore diameter or a separation limit of at most about 0.1 ⁇ to about 0.3 ⁇ , preferably at most about 0.2 ⁇ .
  • the separation limit describes the size at which particles are retained by the sterile filter.
  • the sterile filter is preferably designed as a membrane filter.
  • a membrane filter with a separation limit between about 0.1 ⁇ to about 0.3 ⁇ is also referred to as microfiltration membrane.
  • Bacteria have a size of about 0.2 to about 5 ⁇ and can be filtered out efficiently by means of a microfiltration membrane. Depending on the application, stricter requirements may also be imposed on the sterile filter.
  • sterilization filters having an average pore diameter or a separation limit of approximately 10 nm are provided in one embodiment.
  • the sterile filter is fabricated from a polymer or from an inorganic material, for example a ceramic.
  • the sterile filter is formed as a microporous polymer membrane from a membrane polymer from the group comprising polysulfone, polyethersulfone, cellulose, cellulose derivatives, polyvinylidene fluoride, polyamide, polyester, and polyacrylonitrile and / or combinations thereof.
  • the sterile filter also serves as an absorber surface, whereby liquid is transported away from the outlet opening via the sterile filter and the sterile filter thus advantageously assists in rapid drying of the dispenser.
  • the sterile filter is designed for this purpose as a hydrophilic polymer membrane.
  • the design of the protective cap with an absorber surface contacting the outlet opening is also advantageous in embodiments without a sterile filter.
  • two membranes are provided, which act as a sterile filter or absorber surface.
  • a multilayer membrane is provided in the protective cap, wherein a first layer facing the outlet opening of the dispenser has absorbent properties and a second layer facing the ventilation opening has filter properties.
  • the sterile filter is designed in one embodiment as an insert, which is connected to the protective cap by molding. In other embodiments, the sterile filter is locked with a wall of the protective cap.
  • the protective cap comprises a cylindrical portion and a lid portion connected thereto, wherein the at least one ventilation opening is provided on the lid portion.
  • radially inwardly directed latching projections or a circumferential latching projection are provided on an inner wall of the cylindrical portion, through which (n) the sterile filter is received.
  • protruding latching arms for fastening the sterile filter are provided by an inner side of the lid section. Such locking arms allow reliable, error-free installation.
  • the sterile filter is made of a material which has a sufficient mechanical strength, so that the sterile filter can be engaged in the latching arms or locking projections.
  • the sterile filter is applied to a carrier layer.
  • the carrier layer has material properties deviating from the sterile filter.
  • a gas-permeable, hydrophilic carrier layer is provided, so that the carrier layer is a drying of the dispenser also supported.
  • the carrier layer and the sterile filter are preferably fixed, in particular materially connected to one another, for example adhesively bonded or welded.
  • the sterile filter is vapor-deposited or sputtered onto the carrier layer.
  • the sterile filter is preferably arranged such that in use it contacts an outlet opening of the dispenser, wherein in particular the protective cap has a stop which forces the sterile filter into contact with the outlet opening during use.
  • FIG. 1 shows a dispenser for the discharge of pharmaceutical and / or cosmetic liquids in a sectional view
  • FIG. 2 shows the outlet assembly according to FIG. 1 with a protective cap according to a first exemplary embodiment
  • FIG. 3 shows a discharge device comprising a dispenser and a protective cap in a perspective overall view
  • FIG. 4 shows the discharge device according to FIG. 3 in a sectional view
  • Fig. 5 shows an alternative embodiment of a discharge device comprising a dispenser and a protective cap in a perspective overall view
  • FIG. 6 the discharge device of FIG. 6 in a sectional view.
  • FIG. 1 initially shows a dispenser 2 for dispensing pharmaceutical and / or cosmetic liquids, which is particularly suitable for unpreserved ophthalmics.
  • This dispenser 2 has a liquid reservoir 21 delimited by a container body 20.
  • the liquid 4 is stored in the liquid reservoir 21.
  • An outlet assembly 22 is placed on the container body 20 and fastened by means of a latching connection.
  • This outlet assembly 22 serves the purpose of passing liquid through an outlet channel 23 from the liquid reservoir 21 to an outlet opening 24.
  • the illustrated outlet opening 24 is designed as a drop formation surface and widens conically in the discharge direction.
  • outlet valve 25 is arranged, which closes the outlet channel 23 in a closed state, so that in the discharge direction downstream of the outlet valve 25 located liquid can not get back into the liquid reservoir 21.
  • the outlet valve 25 shown comprises a valve body 27 which can be adjusted against the force of a restoring spring 26 and which cooperates with a valve seat 28 formed on a housing wall. An inflow of air into the liquid reservoir 21 for pressure equalization via a filter element 29.
  • the filter element 29 comprises in advantageous embodiments, a pointing to the liquid reservoir 21 and a liquid side facing away from the liquid reservoir 21 bacterial filter with a separation limit of about 0.2 ⁇ " ⁇ , so bacteria with a size of about 0.2 to about 5 ⁇ are safely retained by the bacteria filter.
  • the illustrated dispenser 2 is designed as a so-called pressure bottle (Engl. Squeeze Bottie).
  • the use of this dispenser 2 takes place in such a way that it is brought into an overhead position with the outlet opening 24 facing downwards.
  • walls of the container body 20 are compressed to pressurize the liquid 4 in the liquid reservoir 21 with a pressure.
  • This pressure causes opening of the exhaust valve 25. More specifically, as soon as the fluid pressure in a portion of the exhaust passage 23 upstream of the exhaust valve 25 is sufficiently high, the valve body 27 is displaced by this pressure against the force of the return spring 26 and provides the path for the liquid in Direction of the outlet opening 24 free. After a discharge, the outlet valve 25 is closed again.
  • the illustrated protective cap 3 has a plurality of ventilation openings 30 for communicating an interior space 31 with an external environment.
  • the protective cap 3 comprises a substantially cylindrical portion 32 and a lid portion 33 connected thereto.
  • the ventilation openings 30 are provided on the lid portion 33.
  • the number of ventilation openings 30 can be suitably selected by the person skilled in the art.
  • the protective cap 3 has three uniformly distributed ventilation openings 30, of which only one is visible in FIG.
  • the protective cap 3 is manufactured as an injection-molded part and has a tamper-evident seal 34 which is to be removed when it is used for the first time.
  • latching elements 35 are provided for latching with the dispenser 2 shown in FIG.
  • the locking elements 35 are designed such that they prevent removal of the protective cap 3 and / or removal of the outlet assembly 22 of the container body 20 without removing the tamper-evident seal 34.
  • the protective cap 3 is also designed such that a repeated removal and clamping of the protective cap 3 on the dispenser 2 is possible.
  • the protective cap 3 is slightly deformed when placed, so that the elastic restoring forces of a protective cap 3 made of plastic produce a clamping action.
  • locking elements are provided for this purpose.
  • the protective cap 3 has a sterile filter 5 covering the ventilation openings 30, by means of which germ introduction into an interior 31 of the protective cap 3 via the ventilation openings 30 is prevented or at least reduced.
  • the sterile filter 5 has a separation limit of a maximum of 0.2 ⁇ m, so that bacteria having a size of approximately 0.2 to approximately 5 ⁇ m are reliably retained.
  • the sterile filter 5 is arranged in the illustrated embodiment parallel to the lid portion 33 of the protective cap 3 on an inner side of the lid portion 33, the ventilation openings 30 covering.
  • locking arms 37 are provided in the illustrated embodiment on the cap 3 on the inside of the lid portion.
  • the latching arms 37 protrude in the longitudinal direction of the protective cap 3 from the lid portion 33.
  • the latching arms 37 are elastically deformed.
  • the sterile filter 5 touches in the mounted state of the cap 3 a the outlet opening 24 associated tip of the dispenser 2.
  • a material of the sterile filter 5 is chosen such that the sterile filter 5 as absorber surface for a rapid distribution of the Area of the outlet opening 24 residual drip and thus a fast drying is available.
  • the sterile filter 5 is designed for this purpose as a hydrophilic polymer membrane of a membrane polymer from the group comprising polysulfone, polyethersulfone, cellulose, cellulose derivatives, polyvinylidene fluoride, polyamide, polyester, and polyacrylonitrile and / or combinations thereof.
  • the illustrated sterile filter 5 is made of a material which has a sufficient rigidity, so that the sterile filter 5 can be engaged in the latching arms 37.
  • Figures 3 and 4 show a discharge device 1 comprising a dispenser 2 according to FIG. 1 and a protective cap 3 similar to FIG. 2 in a perspective overall view and a sectional view, respectively.
  • the protective cap 3 according to FIGS. 3 and 4 likewise essentially corresponds to the protective cap 3 according to FIG. 2 and identical reference symbols are used for identical or similar components.
  • the sterile filter 5 according to FIGS. 3 and 4 is attached to a carrier layer 50.
  • a material of the carrier layer 50 is chosen such that the carrier layer 50 gives the associated sterile filter 5 a higher mechanical strength.
  • the carrier layer 50 is also made in advantageous embodiments of a hydrophilic material, so that a sufficient moisture release over the carrier layer 50 is ensured to the environment.
  • the carrier layer 50 is disposed on an outer side of the sterile filter 5 facing the environment.
  • the carrier layer 50 is arranged on an inner side 31 of the protective cap 3 facing inside of the sterile filter 5.
  • Figures 5 and 6 show a discharge device 1 comprising a dispenser 2 according to FIG.
  • FIG. 1 a further embodiment of a protective cap 3 similar to FIG. 2 in a perspective overall view and a sectional view.
  • the protective cap 3 according to FIGS. 5 and 6 likewise substantially corresponds to the protective cap 3 according to FIG. 2 and identical reference numerals are used for identical or similar components.
  • the protective cap 3 has four ventilation openings 30.
  • the sterile filter 5 in the attached state of the protective cap 3 touches a tip of the dispenser 2 assigned to the outlet opening 24.
  • the protective cap 3 according to FIGS. 5 and 6 has a stop 38 protruding from the inside of the lid portion 33.
  • an additional overcap (not shown) is attached over the protective cap 3.
  • the cap 3 for attachment of this overcap, not shown, the cap 3 according to FIGS. 5 and 6 receiving openings 39.

Abstract

The invention relates to a protective cap for a dispenser (2) for discharging pharmaceutical and/or cosmetic liquids (4). The dispenser (2) has a liquid reservoir (21) and a discharge opening (24) through which the liquid (4) can be dispensed into a surrounding atmosphere. The protective cap (3) has at least one ventilation opening (30) for establishing communication between an interior and an outer surrounding area, and a sterile filter (5) which covers the at least one ventilation opening is arranged on the protective cap (3) in order to reduce or prevent an introduction of microbes into the interior of the protective cap (3) via the at least one ventilation opening. The invention further relates to a discharge device (1) comprising a dispenser (2) and a protective cap (3).

Description

Schutzkappe für einen Spender und Spender zum Austrag von pharmazeutischen und/oder kosmetischen Flüssigkeiten  Protective cap for a dispenser and dispenser for dispensing pharmaceutical and / or cosmetic liquids
Anwendungsgebiet und Stand der Technik Field of application and state of the art
Die Erfindung betrifft eine Schutzkappe für einen Spender und einen Spender zum Austrag von pharmazeutischen und/oder kosmetischen Flüssigkeiten. Ein solcher Spender umfasst ein Flüssigkeitsreservoir und eine Austrittsöffnung, durch die hindurch die Flüssigkeit in eine umgebende Atmosphäre abgegeben werden kann. The invention relates to a protective cap for a dispenser and a dispenser for dispensing pharmaceutical and / or cosmetic liquids. Such a dispenser comprises a liquid reservoir and an outlet opening through which the liquid can be discharged into a surrounding atmosphere.
Eine in dem Flüssigkeitsreservoir bevorratete Flüssigkeit wird für einen Austrag in Richtung der Austrittsöffnung gefördert werden, wobei dies über viele verschiedene Mechanismen erfolgen kann. So kann das Flüssigkeitsreservoir als Quetschflasche ausgebildet sein, deren Inhalt durch Verformung der Wandungen unter Druck gesetzt werden kann. Auch eine separate Pumpeinrichtung ist verwendbar. A stored in the liquid reservoir liquid will be promoted for discharge in the direction of the outlet opening, which can be done via many different mechanisms. Thus, the liquid reservoir may be formed as a squeeze bottle, the content of which can be pressurized by deformation of the walls. Also, a separate pumping device is used.
Gattungsgemäße Spender sind aus dem Stand der Technik, beispielsweise aus DE 10 201 1 086 755 A1 bekannt. Der Spender umfasst einen Auslasskanal, der das Flüssigkeitsreservoir mit der Austrittsöffnung verbindet, und ein in dem Auslasskanal angeordnetes, druckabhängig öffnendes oder manuell betätigbares Auslassventil, wobei das Auslassventil im geschlossenen Zustand den Auslasskanal schließt. Das Auslassventil unterteilt den Auslasskanal dabei in einen ersten Teilabschnitt und einen zweiten Teilabschnitt, wobei der zweite Teilabschnitt sich angrenzend an die Austrittsöffnung in Richtung Flüssigkeitsreservoir erstreckt. In anderen Ausgestaltungen entspricht der zweite Teilabschnitt einer Tropfenbildungsfläche an der Austrittsöffnung. Generic dispensers are known from the prior art, for example from DE 10 201 1 086 755 A1. The dispenser comprises an outlet channel connecting the liquid reservoir to the outlet opening and a pressure-dependent opening or manually operable outlet valve arranged in the outlet channel, the outlet valve closing the outlet channel in the closed state. In this case, the outlet valve divides the outlet channel into a first partial section and a second partial section, wherein the second partial section extends adjacent to the outlet opening in the direction of the liquid reservoir. In other embodiments, the second portion corresponds to a drop formation surface at the exit opening.
In jedem Fall führt das Auslassventil dazu, dass nach Schließen desselben keinerlei Flüssigkeit, welche bis in einen Abschnitt des Auslasskanals auf einer dem Flüssigkeitsreservoir abgewandten Seite des Auslassventils gelangt ist oder welche in der Umgebung der Austrittsöffnung außerhalb des Auslasskanals verblieben ist, zurück in den Spender eingesogen werden kann. Eine mögliche Kontamination des Inhaltes des Flüssigkeitsreservoirs durch zurückgesogene Flüssigkeitsreste wird dadurch verhindert. Die Restflüssigkeit verbleibt daher in einem von außen zugänglichen Bereich. Bei Kontakt mit der Atmosphäre kommt es zu einem schnellen Abtrocknen der Restflüssigkeit. Um auch beim Aufsetzen einer Schutzkappe auf den Spender ein rasches Abtrocknens der Restflüssigkeit zu ermöglichen, ist es aus DE 10 201 1 086 755 A1 bekannt, die Schutzkappe des Spenders mit Belüftungsöffnungen zu versehen, die eine dauerhafte Verbindung zwischen dem Bereich, an welchem eine Restflüssigkeit verbleiben kann, und einer äußeren Umgebung schaffen. Die Belüftungsöffnungen können ihrerseits jedoch wieder eine Kontamination verursachen. In any case, the exhaust valve results in that after closing it no liquid, which has passed into a portion of the outlet channel on a side facing away from the liquid reservoir side of the outlet valve or which is left in the vicinity of the outlet opening outside the outlet channel, sucked back into the dispenser can be. A possible contamination of the contents of the liquid reservoir by liquid residues that have been sucked back is thereby prevented. The residual liquid therefore remains in an externally accessible area. Upon contact with the atmosphere, the residual liquid dries quickly. In order to allow a rapid drying of the residual liquid even when placing a protective cap on the dispenser, it is known from DE 10 201 1 086 755 A1 to provide the protective cap of the dispenser with ventilation openings, which provide a permanent connection between the area at which a residual liquid can remain and create an external environment. The vents, however, may in turn cause contamination.
Gemäß DE 10 201 1 086 755 A1 ist zur Vermeidung einer Kontamination vorgesehen, dass Oberflächen des Auslasskanals stromabwärts des Auslassventils, betrachtet in Austragrichtung, und/oder eine Außenoberfläche eines die Austrittsöffnung umgebenden Gehäuses antibakteriell ausgebildet sind, wobei die antibakterielle Ausbildung ausschließlich auf diese Oberflächen beschränkt ist. According to DE 10 201 1 086 755 A1, in order to avoid contamination, it is provided that surfaces of the outlet channel downstream of the outlet valve, viewed in the discharge direction, and / or an outer surface of a housing surrounding the outlet opening are made antibacterial, the antibacterial formation being limited exclusively to these surfaces is.
Aufgabe und Lösung Task and solution
Aufgabe der Erfindung ist es, eine Schutzkappe für einen Spender zur Verfügung zu stellen, welche eine schnelle Abtrocknung erlaubt und bei welcher die Problematik eines Eindringens von Mikroorganismen in die Schutzkappe gemildert wird. Aufgabe der Erfindung ist es weiter, einen Spender mit einer entsprechenden Schutzkappe zur Verfügung zu stellen. The object of the invention is to provide a protective cap for a dispenser, which allows rapid drying and in which the problem of penetration of microorganisms is mitigated into the protective cap. The object of the invention is further to provide a dispenser with a corresponding protective cap available.
Diese Aufgabe wird durch die Gegenstände mit den Merkmalen der Ansprüche 1 und 10 gelöst. Weitere Vorteile der Erfindung ergeben sich aus den Unteransprüchen. This object is solved by the objects with the features of claims 1 and 10. Further advantages of the invention will become apparent from the dependent claims.
Gemäß einem ersten Aspekt wird eine Schutzkappe für einen Spender zum Austrag von pharmazeutischen und/oder kosmetischen Flüssigkeiten geschaffen, wobei der Spender ein Flüssigkeitsreservoir und eine Austrittsöffnung, durch die hindurch die Flüssigkeit in eine umgebende Atmosphäre abgegeben werden kann, aufweist, und wobei die Schutzkappe mindestens eine Belüftungsöffnung zum Kommunizieren eines Innenraums mit einer äußeren Umgebung aufweist, und an der Schutzkappe ein die mindestens eine Belüftungsöffnung abdeckender Sterilfilter angeordnet ist, um einen Keimeintrag über die mindestens eine Belüftungsöffnung in den Innenraum der Schutzkappe zu reduzieren oder zu verhindern. According to a first aspect, there is provided a protective cap for a dispenser for dispensing pharmaceutical and / or cosmetic liquids, the dispenser having a liquid reservoir and an outlet opening through which the liquid can be dispensed into a surrounding atmosphere, and wherein the protective cap is at least a ventilation opening for communicating an interior space with an external environment, and on the protective cap a sterile filter covering the at least one ventilation opening is arranged in order to reduce or prevent germ introduction via the at least one ventilation opening into the interior of the protective cap.
Gemäß einem zweiten Aspekt wird eine Austragvorrichtung geschaffen, umfassend einen Spender zum Austrag von pharmazeutischen und/oder kosmetischen Flüssigkeiten mit einem Flüssigkeitsreservoir und einer Austrittsöffnung, durch die hindurch die Flüssigkeit in eine umgebende Atmosphäre abgegeben werden kann, und eine Schutzkappe, die mindestens eine Belüftungsöffnung zum Kommunizieren eines Innenraums mit einer äußeren Umgebung aufweist, wobei an der Schutzkappe ein die mindestens eine Belüftungsöffnung abdeckender Sterilfilter angeordnet ist, um einen Keimeintrag über die mindestens eine Belüftungsöffnung in den Innenraum der Schutzkappe zu reduzieren oder zu verhindern. According to a second aspect, there is provided a dispensing apparatus comprising a dispenser for dispensing pharmaceutical and / or cosmetic liquids having a liquid reservoir and an outlet opening through which the liquid can be dispensed into a surrounding atmosphere, and a protective cap having at least one ventilation opening for Communicating an interior with an external environment wherein a sterile filter covering the at least one ventilation opening is arranged on the protective cap in order to reduce or prevent germ introduction via the at least one ventilation opening into the interior of the protective cap.
Durch den Sterilfilter wird ein Keimeintrag in einen Innenraum der Schutzkappe über die mindestens eine Belüftungsöffnung verhindert oder zumindest reduziert. Als Keime oder Mikroorganismen im Sinne der vorliegenden Erfindung werden sämtliche mikrobiellen Krankheitserreger, insbesondere Bakterien und Viren, verstanden. Through the sterile filter, germ introduction into an interior of the protective cap via the at least one ventilation opening is prevented or at least reduced. As germs or microorganisms in the context of the present invention are meant all microbial pathogens, in particular bacteria and viruses.
Der Spender ist insbesondere für unkonservierte Ophthalmika geeignet. In vorteilhaften Ausgestaltungen umfasst der Spender einen Auslasskanal, der das Flüssigkeitsreservoir mit der Austrittsöffnung verbindet, und ein druckabhängig öffnendes oder manuell betätigbares Auslassventil, welches in dem Auslasskanal angeordnet ist und welches in einem geschlossenen Zustand den Auslasskanal schließt. Das Auslassventil verhindert dabei ein Eindringen von Keimen in das Flüssigkeitsreservoir. Bei dem Auslassventil handelt es sich vorzugsweise um ein druckabhängig öffnendes Auslassventil, welches durch Druckbeaufschlagung der Flüssigkeit in dem Flüssigkeitsreservoir oder einer hieraus entnommenen Teilcharge geöffnet wird und selbsttätig wieder schließt, sobald der entsprechende Überdruck gegenüber der Umgebung entfällt. Grundsätzlich sind hier jedoch auch andere Ventiltypen verwendbar. So kann beispielsweise vorgesehen sein, dass die Flüssigkeit im Flüssigkeitsreservoir permanent unter Druck steht und die Handhabung des Spenders über eine Handhabe erfolgt, deren manuelle Betätigung das Auslassventil öffnet. Das Auslassventil verhindert ein Rücksaugen ausgetragener Flüssigkeit in das Flüssigkeitsreservoir. Die mindestens eine Belüftungsöffnung bewirkt ein rasches Abtrocknen dieser Restflüssigkeit. The dispenser is particularly suitable for unpreserved ophthalmics. In advantageous embodiments, the dispenser comprises an outlet channel which connects the liquid reservoir to the outlet opening, and a pressure-dependent opening or manually operable outlet valve which is arranged in the outlet channel and which closes the outlet channel in a closed state. The outlet valve prevents penetration of germs into the liquid reservoir. The outlet valve is preferably a pressure-dependent opening outlet valve, which is opened by pressurizing the liquid in the liquid reservoir or a partial charge removed therefrom and automatically closes again as soon as the corresponding overpressure relative to the environment is eliminated. In principle, however, other types of valves can be used here. Thus, for example, be provided that the liquid in the liquid reservoir is permanently under pressure and the handling of the dispenser via a handle, whose manual operation opens the outlet valve. The outlet valve prevents a sucked back liquid in the liquid reservoir. The at least one ventilation opening causes a rapid drying of this residual liquid.
Der Sterilfilter weist vorzugsweise einen mittleren Porendurchmesser oder eine Trenngrenze von maximal ca. 0,1 μηη bis ca. 0,3 μηη, vorzugsweise maximal ca. 0,2μηΊ auf. Die Trenngrenze beschreibt, ab welcher Größe Partikel durch den Sterilfilter zurückgehalten werden. Der Sterilfilter ist vorzugsweise als Membranfilter gestaltet. Ein Membranfilter mit einer Trenngrenze zwischen ca. 0,1 μηη bis ca. 0,3 μηη wird auch als Mikrofiltrationsmembran bezeichnet. Bakterien haben eine Größe von ca. 0.2 bis ca. 5 μηη und lassen sich effizient mittels einer Mikrofiltrationsmembran herausfiltern. Je nach Anwendung können auch strengere Anforderungen an den Sterilfilter gestellt sein. Insbesondere sind in einer Ausgestaltungen Sterilfilter mit einem mittleren Porendurchmesser oder einer Trenngrenze von ca. 10 nm vorgesehen. Derartige Membranfilter werden auch als Ultrafiltrationsmembran bezeichnet. Mit einer Ultrafiltrationsmembran lassen sich auch Viren mit einer Größe von 15 nm herausfiltern. Der Sterilfilter ist in einer Ausgestaltung als Gewebe aus einem Polymer oder aus einem anorganischen Material, beispielsweise einer Keramik gefertigt. In vorteilhaften Ausgestaltungen ist der Sterilfilter als mikroporöse Polymermembran aus einem Membranpolymer aus der Gruppe umfassend Polysulfon, Polyethersulfon, Cellulose, Cellulosederivate, Polyvinylidenfluorid, Polyamid, Polyester, und Polyacrylnitril und/oder Kombinationen davon ausgebildet. The sterile filter preferably has an average pore diameter or a separation limit of at most about 0.1 μηη to about 0.3 μηη, preferably at most about 0.2μηΊ. The separation limit describes the size at which particles are retained by the sterile filter. The sterile filter is preferably designed as a membrane filter. A membrane filter with a separation limit between about 0.1 μηη to about 0.3 μηη is also referred to as microfiltration membrane. Bacteria have a size of about 0.2 to about 5 μηη and can be filtered out efficiently by means of a microfiltration membrane. Depending on the application, stricter requirements may also be imposed on the sterile filter. In particular, sterilization filters having an average pore diameter or a separation limit of approximately 10 nm are provided in one embodiment. Such membrane filters are also referred to as ultrafiltration membrane. With an ultrafiltration membrane also viruses with a size of 15 nm can be filtered out. In one embodiment, the sterile filter is fabricated from a polymer or from an inorganic material, for example a ceramic. In advantageous embodiments, the sterile filter is formed as a microporous polymer membrane from a membrane polymer from the group comprising polysulfone, polyethersulfone, cellulose, cellulose derivatives, polyvinylidene fluoride, polyamide, polyester, and polyacrylonitrile and / or combinations thereof.
Vorzugsweise dient der Sterilfilter auch als Absorberfläche, wobei über den Sterilfilter Flüssigkeit von der Austrittsöffnung weg transportiert wird und der Sterilfilter so ein schnelles Abtrocknen des Spenders vorteilhaft unterstützt. Der Sterilfilter ist zu diesem Zweck als hydrophile Polymermembran gestaltet. Die Gestaltung der Schutzkappe mit einer die Austrittsöffnung kontaktierenden Absorberfläche ist auch in Ausgestaltungen ohne Sterilfilter vorteilhaft. In einer Ausgestaltung sind zwei Membranen vorgesehen, welche als Sterilfilter bzw. Absorberfläche fungieren. In wieder anderen Ausgestaltungen ist eine mehrschichtige Membran in der Schutzkappe vorgesehen, wobei eine erste der Austrittsöffnung des Spenders zugewandte Schicht absorbierende Eigenschaften aufweist und eine zweite, der Belüftungsöffnung zugewandte Schicht Filtereigenschaften aufweist. Preferably, the sterile filter also serves as an absorber surface, whereby liquid is transported away from the outlet opening via the sterile filter and the sterile filter thus advantageously assists in rapid drying of the dispenser. The sterile filter is designed for this purpose as a hydrophilic polymer membrane. The design of the protective cap with an absorber surface contacting the outlet opening is also advantageous in embodiments without a sterile filter. In one embodiment, two membranes are provided, which act as a sterile filter or absorber surface. In yet other embodiments, a multilayer membrane is provided in the protective cap, wherein a first layer facing the outlet opening of the dispenser has absorbent properties and a second layer facing the ventilation opening has filter properties.
Der Sterilfilter ist in einer Ausgestaltung als Einlegeteil gestaltet, welches mit der Schutzkappe durch Umspritzen verbunden wird. In anderen Ausgestaltungen ist der Sterilfilter mit einer Wandung der Schutzkappe verrastet. The sterile filter is designed in one embodiment as an insert, which is connected to the protective cap by molding. In other embodiments, the sterile filter is locked with a wall of the protective cap.
In vorteilhaften Ausgestaltungen ist vorgesehen, dass die Schutzkappe einen zylindrischen Abschnitt und einen damit verbundenen Deckelabschnitt umfasst, wobei die mindestens eine Belüftungsöffnung an dem Deckelabschnitt vorgesehen ist. In einer Ausgestaltung sind an einer Innenwandung des zylindrischen Abschnitts radial nach innenweisende Rastvorsprünge oder ein umlaufender Rastvorsprung vorgesehen, durch welche(n) der Sterilfilter aufgenommen ist. In vorteilhaften Ausgestaltungen sind von einer Innenseite des Deckelabschnitts abragende Rastarme zur Befestigung des Sterilfilters vorgesehen. Derartige Rastarme erlauben eine zuverlässige, fehlerfreie Montage. In advantageous embodiments, it is provided that the protective cap comprises a cylindrical portion and a lid portion connected thereto, wherein the at least one ventilation opening is provided on the lid portion. In one embodiment, radially inwardly directed latching projections or a circumferential latching projection are provided on an inner wall of the cylindrical portion, through which (n) the sterile filter is received. In advantageous embodiments, protruding latching arms for fastening the sterile filter are provided by an inner side of the lid section. Such locking arms allow reliable, error-free installation.
In vorteilhaften Ausgestaltungen ist der Sterilfilter aus einem Material, welches eine ausreichende mechanische Festigkeit aufweist, sodass der Sterilfilter in die Rastarme oder Rastvorsprünge eingerastet werden kann. In anderen Ausgestaltungen ist der Sterilfilter auf einer Trägerschicht aufgebracht. Die Trägerschicht weist dabei in einer Ausgestaltung von dem Sterilfilter abweichende Materialeigenschaften auf. Vorzugsweise ist eine gasdurchlässige, hydrophile Trägerschicht vorgesehen, sodass die Trägerschicht ein Abtrocknen des Spenders ebenfalls unterstützt. Die Trägerschicht und der Sterilfilter sind vorzugsweise fest, insbesondere stoffschlüssig miteinander verbunden, beispielsweise verklebt oder verschweißt. In einer Ausgestaltung wird der Sterilfilter auf die Trägerschicht aufgedampft oder aufgesputtert. In advantageous embodiments of the sterile filter is made of a material which has a sufficient mechanical strength, so that the sterile filter can be engaged in the latching arms or locking projections. In other embodiments, the sterile filter is applied to a carrier layer. In one embodiment, the carrier layer has material properties deviating from the sterile filter. Preferably, a gas-permeable, hydrophilic carrier layer is provided, so that the carrier layer is a drying of the dispenser also supported. The carrier layer and the sterile filter are preferably fixed, in particular materially connected to one another, for example adhesively bonded or welded. In one embodiment, the sterile filter is vapor-deposited or sputtered onto the carrier layer.
Der Sterilfilter ist vorzugsweise derart angeordnet, dass er im Gebrauch eine Austrittsöffnung des Spenders kontaktiert, wobei insbesondere die Schutzkappe einen Anschlag aufweist, welche den Sterilfilter im Gebrauch in Kontakt mit der Austrittsöffnung zwingt. Dadurch ist eine vorteilhafte Nutzung des Sterilfilters als Absorber möglich. The sterile filter is preferably arranged such that in use it contacts an outlet opening of the dispenser, wherein in particular the protective cap has a stop which forces the sterile filter into contact with the outlet opening during use. As a result, an advantageous use of the sterile filter as an absorber is possible.
Kurzbeschreibung der Zeichnungen Brief description of the drawings
Weitere Vorteile und Aspekte der Erfindung ergeben sich außer aus den Ansprüchen auch aus der nachfolgenden Beschreibung von bevorzugten Ausführungsbeispielen der Erfindung, die nachfolgend anhand der Figuren erläutert sind. Für gleiche oder ähnliche Bauteile werden in den Zeichnungen einheitliche Bezugszeichen verwendet. Als Teil eines Ausführungsbeispiels beschriebene oder dargestellte Merkmale können ebenso in einem anderen Ausführungsbeispiel verwendet werden, um eine weitere Ausführungsform der Erfindung zu erhalten. Es zeigen: Other advantages and aspects of the invention will become apparent from the claims and from the following description of preferred embodiments of the invention, which are explained below with reference to the figures. For identical or similar components, the same reference numbers are used in the drawings. Features described or illustrated as part of one embodiment may also be used in another embodiment to obtain a further embodiment of the invention. Show it:
Fig. 1 einen Spender zum Austrag von pharmazeutischen und/oder kosmetischen Flüssigkeiten in einer Schnittdarstellung, 1 shows a dispenser for the discharge of pharmaceutical and / or cosmetic liquids in a sectional view,
Fig. 2 die Auslassbaugruppe gemäß Fig. 1 mit einer Schutzkappe gemäß einem ersten Ausführungsbeispiel; FIG. 2 shows the outlet assembly according to FIG. 1 with a protective cap according to a first exemplary embodiment; FIG.
Fig. 3 eine Austragvorrichtung umfassend einen Spender und eine Schutzkappe in einer perspektivischen Gesamtdarstellung, 3 shows a discharge device comprising a dispenser and a protective cap in a perspective overall view,
Fig. 4 die Austragvorrichtung gemäß Fig. 3 in einer Schnittdarstellung, 4 shows the discharge device according to FIG. 3 in a sectional view, FIG.
Fig. 5 eine alternative Ausgestaltung einer Austragvorrichtung umfassend einen Spender und eine Schutzkappe in einer perspektivischen Gesamtdarstellung und Fig. 5 shows an alternative embodiment of a discharge device comprising a dispenser and a protective cap in a perspective overall view and
Fig. 6 die Austragvorrichtung gemäß Fig. 6 in einer Schnittdarstellung. Detaillierte Beschreibung der Ausführungsbeispiele Fig. 6, the discharge device of FIG. 6 in a sectional view. Detailed description of the embodiments
Figur 1 zeigt zunächst einen Spender 2 zum Austrag von pharmazeutischen und/oder kosmetischen Flüssigkeiten, welcher insbesondere für unkonservierte Ophthalmika geeignet ist. FIG. 1 initially shows a dispenser 2 for dispensing pharmaceutical and / or cosmetic liquids, which is particularly suitable for unpreserved ophthalmics.
Dieser Spender 2 verfügt über ein von einem Behälterkörper 20 begrenztes Flüssigkeitsreservoir 21. In dem Flüssigkeitsreservoir 21 ist die Flüssigkeit 4 bevorratet. Auf den Behälterkörper 20 ist eine Auslassbaugruppe 22 aufgesetzt und mittels einer Rastverbindung befestigt. Diese Auslassbaugruppe 22 dient dem Zweck, durch einen Auslasskanal 23 hindurch Flüssigkeit von dem Flüssigkeitsreservoir 21 bis zu einer Austrittsöffnung 24 zu leiten. Die dargestellte Austrittsöffnung 24 ist als Tropfenbildungsfläche gestaltet und weitet sich konisch in Austragrichtung. This dispenser 2 has a liquid reservoir 21 delimited by a container body 20. The liquid 4 is stored in the liquid reservoir 21. An outlet assembly 22 is placed on the container body 20 and fastened by means of a latching connection. This outlet assembly 22 serves the purpose of passing liquid through an outlet channel 23 from the liquid reservoir 21 to an outlet opening 24. The illustrated outlet opening 24 is designed as a drop formation surface and widens conically in the discharge direction.
In der Darstellung der Fig. 1 ist aufgrund der Schnittebene lediglich ein letztes Teilstück des Auslasskanals 23 dargestellt. In dem Auslasskanal 23 ist ein Auslassventil 25 angeordnet, welches in einem geschlossenen Zustand den Auslasskanal 23 schließt, sodass in Austragrichtung stromabwärts des Auslassventils 25 befindliche Flüssigkeit nicht in das Flüssigkeitsreservoir 21 zurückgelangen kann. Das dargestellte Auslassventil 25 umfasst einen gegen die Kraft einer Rückstellfeder 26 verstellbaren Ventilkörper 27, welcher mit einem an einer Gehäusewandung gebildeten Ventilsitz 28 zusammenwirkt. Ein Einströmen von Luft in das Flüssigkeitsreservoir 21 für einen Druckausgleich erfolgt über ein Filterelement 29. Das Filterelement 29 umfasst in vorteilhaften Ausgestaltungen einen zu dem Flüssigkeitsreservoir 21 hin weisenden Flüssigkeitsfilter und einen von dem Flüssigkeitsreservoir 21 weg weisenden Bakterienfilter mit einer Trenngrenze von ca. 0,2μη"ΐ, sodass Bakterien mit einer Größe von ca. 0.2 bis ca. 5 μηη durch den Bakterienfilter sicher zurückgehalten werden. In the illustration of FIG. 1, only a last section of the outlet channel 23 is shown due to the sectional plane. In the outlet channel 23, an outlet valve 25 is arranged, which closes the outlet channel 23 in a closed state, so that in the discharge direction downstream of the outlet valve 25 located liquid can not get back into the liquid reservoir 21. The outlet valve 25 shown comprises a valve body 27 which can be adjusted against the force of a restoring spring 26 and which cooperates with a valve seat 28 formed on a housing wall. An inflow of air into the liquid reservoir 21 for pressure equalization via a filter element 29. The filter element 29 comprises in advantageous embodiments, a pointing to the liquid reservoir 21 and a liquid side facing away from the liquid reservoir 21 bacterial filter with a separation limit of about 0.2μη "ΐ, so bacteria with a size of about 0.2 to about 5 μηη are safely retained by the bacteria filter.
Der dargestellte Spender 2 ist als sogenannte Drückflasche (Engl. Squeeze Bottie) gestaltet. Die Verwendung dieses Spenders 2 erfolgt derart, dass dieser in einen Überkopflage mit nach unten weisender Austrittsöffnung 24 gebracht wird. Anschließend werden Wandungen des Behälterkörpers 20 zusammengedrückt, um die Flüssigkeit 4 in dem Flüssigkeitsreservoir 21 mit einem Druck zu beaufschlagen. Dieser Druck bewirkt ein Öffnen des Auslassventils 25. Genauer wird, sobald der Flüssigkeitsdruck in einem Teilabschnitt des Auslasskanals 23 stromaufwärts des Auslassventils 25 ausreichend hoch ist, der Ventilkörper 27 durch diesen Druck entgegen der Kraft der Rückstellfeder 26 verlagert und gibt den Weg für die Flüssigkeit in Richtung der Austrittsöffnung 24 frei. Nach einem Austrag wird das Auslassventil 25 wieder verschlossen. Dabei verbleibt in der Regel ein Rest der Flüssigkeit, der so genannte Resttropfen, an der als Tropfenbildungsfläche gestalteten Austrittsöffnung 24 sowie in einem der Austrittsöffnung 24 zugeordneten Teilabschnitt des Auslasskanals 23 stromabwärts des Auslassventils 25 in Austragrichtung. Ein Rückfluss in das Flüssigkeitsreservoir 12 ist aufgrund des druckabhängig öffnenden Auslassventils 25 nicht möglich. The illustrated dispenser 2 is designed as a so-called pressure bottle (Engl. Squeeze Bottie). The use of this dispenser 2 takes place in such a way that it is brought into an overhead position with the outlet opening 24 facing downwards. Subsequently, walls of the container body 20 are compressed to pressurize the liquid 4 in the liquid reservoir 21 with a pressure. This pressure causes opening of the exhaust valve 25. More specifically, as soon as the fluid pressure in a portion of the exhaust passage 23 upstream of the exhaust valve 25 is sufficiently high, the valve body 27 is displaced by this pressure against the force of the return spring 26 and provides the path for the liquid in Direction of the outlet opening 24 free. After a discharge, the outlet valve 25 is closed again. As a rule, a remainder of the liquid, the so-called residual drop, remains at the outlet opening 24 designed as a droplet formation surface and in a partial section of the outlet channel 23 assigned to the outlet opening 24 downstream of the outlet valve 25 in the discharge direction. A backflow into the liquid reservoir 12 is not possible due to the pressure-dependent opening exhaust valve 25.
Ohne Aufsetzen einer Schutzkappe, kann der Resttropfen schnell abtrocknen. Um auch bei aufgesetzter Schutzkappe ein schnelles Abtrocken zu ermöglichen, weisen gattungsgemäße Schutzkappen mindestens eine Belüftungsöffnung auf. Without putting on a protective cap, the residual droplet can dry quickly. In order to allow a quick drying even when attached protective cap, have generic protective caps on at least one vent opening.
Die Fig. 2 zeigt die Auslassbaugruppe 22 mit einer darauf aufgesetzten Schutzkappe 3. Die dargestellte Schutzkappe 3 weist mehrere Belüftungsöffnungen 30 zum Kommunizieren eines Innenraums 31 mit einer äußeren Umgebung auf. Die Schutzkappe 3 umfasst einen im Wesentlichen zylindrischen Abschnitt 32 und einen damit verbundenen Deckelabschnitt 33. Bei der Schutzkappe 3 gemäß Fig. 2 sind die Belüftungsöffnungen 30 an dem Deckelabschnitt 33 vorgesehen. Die Zahl der Belüftungsöffnungen 30 ist durch den Fachmann geeignet wählbar. In der Ausführungsform gemäß Fig. 2 weist die Schutzkappe 3 drei gleichmäßig verteilt angeordnete Belüftungsöffnungen 30 auf, von welchen in Fig. 1 nur eine sichtbar ist. Die Schutzkappe 3 ist als Spritzgussteil gefertigt und weist ein Originalitätssiegel 34 auf, welches bei einem Erstgebrauch zu entfernen ist. An einer Innenwandung sind Rastelemente 35 zum Verrasten mit dem Spender 2 gemäß Fig. 1 vorgesehen. Die Rastelemente 35 sind dabei derart gestaltet, dass sie ein Abnehmen der Schutzkappe 3 und/oder ein Abziehen der Auslassbaugruppe 22 von dem Behälterkörper 20 ohne Entfernen des Originalitätssiegels 34 verhindern. Die Schutzkappe 3 ist zudem derart gestaltet, dass ein wiederholtes Abnehmen und klemmendes Aufsetzen der Schutzkappe 3 auf den Spender 2 möglich ist. Zu diesem Zweck wird die Schutzkappe 3 bei Aufsetzen leicht verformt, sodass die elastischen Rückstellkräfte einer aus Kunststoff gefertigten Schutzkappe 3 eine Klemmwirkung erzeugen. In anderen Ausgestaltungen sind zu diesem Zweck Rastelemente vorgesehen. 2 shows the outlet assembly 22 with a protective cap 3 placed thereon. The illustrated protective cap 3 has a plurality of ventilation openings 30 for communicating an interior space 31 with an external environment. The protective cap 3 comprises a substantially cylindrical portion 32 and a lid portion 33 connected thereto. In the protective cap 3 according to FIG. 2, the ventilation openings 30 are provided on the lid portion 33. The number of ventilation openings 30 can be suitably selected by the person skilled in the art. In the embodiment according to FIG. 2, the protective cap 3 has three uniformly distributed ventilation openings 30, of which only one is visible in FIG. The protective cap 3 is manufactured as an injection-molded part and has a tamper-evident seal 34 which is to be removed when it is used for the first time. On an inner wall latching elements 35 are provided for latching with the dispenser 2 shown in FIG. The locking elements 35 are designed such that they prevent removal of the protective cap 3 and / or removal of the outlet assembly 22 of the container body 20 without removing the tamper-evident seal 34. The protective cap 3 is also designed such that a repeated removal and clamping of the protective cap 3 on the dispenser 2 is possible. For this purpose, the protective cap 3 is slightly deformed when placed, so that the elastic restoring forces of a protective cap 3 made of plastic produce a clamping action. In other embodiments locking elements are provided for this purpose.
Gemäß der Anmeldung weist die Schutzkappe 3 einen die Belüftungsöffnungen 30 abdeckenden Sterilfilter 5 auf, durch welchen ein Keimeintrag in einen Innenraum 31 der Schutzkappe 3 über die Belüftungsöffnungen 30 verhindert oder zumindest verringert wird. Der Sterilfilter 5 weist eine Trenngrenze von maximal 0,2μηι auf, sodass Bakterien mit einer Größe von ca. 0.2 bis ca. 5 μηι sicher zurückgehalten werden. Der Sterilfilter 5 ist in dem dargestellten Ausführungsbeispiel parallel zu dem Deckelabschnitt 33 der Schutzkappe 3 an einer Innenseite des Deckelabschnitts 33, die Belüftungsöffnungen 30 abdeckend angeordnet. Für eine Befestigung des Sterilfilters 5 sind in dem dargestellten Ausführungsbeispiel an der Schutzkappe 3 an der Innenseite des Deckelabschnitts 33 Rastarme 37 vorgesehen. Die Rastarme 37 ragen in Längsrichtung der Schutzkappe 3 von dem Deckelabschnitt 33 ab. Zum Anbringen des Sterilfilters 5 werden die Rastarme 37 elastisch verformt. According to the application, the protective cap 3 has a sterile filter 5 covering the ventilation openings 30, by means of which germ introduction into an interior 31 of the protective cap 3 via the ventilation openings 30 is prevented or at least reduced. The sterile filter 5 has a separation limit of a maximum of 0.2 μm, so that bacteria having a size of approximately 0.2 to approximately 5 μm are reliably retained. The sterile filter 5 is arranged in the illustrated embodiment parallel to the lid portion 33 of the protective cap 3 on an inner side of the lid portion 33, the ventilation openings 30 covering. For attachment of the sterile filter 5 33 locking arms 37 are provided in the illustrated embodiment on the cap 3 on the inside of the lid portion. The latching arms 37 protrude in the longitudinal direction of the protective cap 3 from the lid portion 33. For attaching the sterile filter 5, the latching arms 37 are elastically deformed.
Wie in Figur 2 erkennbar ist, berührt der Sterilfilter 5 im aufgesetzten Zustand der Schutzkappe 3 eine der Austrittsöffnung 24 zugeordnete Spitze des Spenders 2. Ein Material des Sterilfilters 5 ist dabei derart gewählt, dass der Sterilfilter 5 auch als Absorberfläche für eine schnelle Verteilung des im Bereich der Austrittsöffnung 24 verbleibenden Resttropfens und damit eine schnelle Abtrocknung nutzbar ist. In einer Ausgestaltung ist der Sterilfilter 5 zu diesem Zweck als hydrophile Polymermembran aus einem Membranpolymer aus der Gruppe umfassend Polysulfon, Polyethersulfon, Cellulose, Cellulosederivate, Polyvinylidenfluorid, Polyamid, Polyester, und Polyacrylnitril und/oder Kombinationen davon ausgebildet. Der dargestellte Sterilfilter 5 ist aus einem Material, welches eine ausreichende Steifigkeit aufweist, sodass der Sterilfilter 5 in die Rastarme 37 eingerastet werden kann. As can be seen in Figure 2, the sterile filter 5 touches in the mounted state of the cap 3 a the outlet opening 24 associated tip of the dispenser 2. A material of the sterile filter 5 is chosen such that the sterile filter 5 as absorber surface for a rapid distribution of the Area of the outlet opening 24 residual drip and thus a fast drying is available. In one embodiment, the sterile filter 5 is designed for this purpose as a hydrophilic polymer membrane of a membrane polymer from the group comprising polysulfone, polyethersulfone, cellulose, cellulose derivatives, polyvinylidene fluoride, polyamide, polyester, and polyacrylonitrile and / or combinations thereof. The illustrated sterile filter 5 is made of a material which has a sufficient rigidity, so that the sterile filter 5 can be engaged in the latching arms 37.
Die Figuren 3 und 4 zeigen eine Austragvorrichtung 1 umfassend einen Spender 2 gemäß Fig. 1 und eine Schutzkappe 3 ähnlich Fig. 2 in einer perspektivischen Gesamtdarstellung bzw. einer Schnittdarstellung. Für eine Beschreibung des Spenders 2 wird auf oben verwiesen. Die Schutzkappe 3 gemäß den Fig. 3 und 4 entspricht ebenfalls im Wesentlichen der Schutzkappe 3 gemäß Fig. 2 und für gleiche oder ähnliche Bauteile werden einheitliche Bezugszeichen verwendet. Figures 3 and 4 show a discharge device 1 comprising a dispenser 2 according to FIG. 1 and a protective cap 3 similar to FIG. 2 in a perspective overall view and a sectional view, respectively. For a description of the dispenser 2, see above. The protective cap 3 according to FIGS. 3 and 4 likewise essentially corresponds to the protective cap 3 according to FIG. 2 and identical reference symbols are used for identical or similar components.
Im Unterschied zu der Ausführungsform gemäß Fig. 2 ist der Sterilfilter 5 gemäß Fig. 3 und 4 an einer Trägerschicht 50 angebracht. Ein Material der Trägerschicht 50 ist derart gewählt, dass die Trägerschicht 50 dem damit verbundenen Sterilfilter 5 eine höhere mechanische Festigkeit verleiht. Die Trägerschicht 50 ist in vorteilhaften Ausgestaltungen ebenfalls aus einem hydrophilen Material gefertigt, damit eine ausreichende Feuchtigkeitsabgabe über die Trägerschicht 50 an die Umgebung gewährleistet ist. In dem dargestellten Ausführungsbeispiel ist die Trägerschicht 50 an einer der Umgebung zugewandten Außenseite des Sterilfilters 5 angeordnet. In anderen Ausgestaltungen ist die Trägerschicht 50 an einer dem Innenraum 31 der Schutzkappe 3 zugewandten Innenseite des Sterilfilters 5 angeordnet. Die Figuren 5 und 6 zeigen eine Austragvorrichtung 1 umfassend einen Spender 2 gemäß Fig. 1 und eine weitere Ausgestaltung einer Schutzkappe 3 ähnlich Fig. 2 in einer perspektivischen Gesamtdarstellung bzw. einer Schnittdarstellung. Für eine Beschreibung des Spenders 2 wird auf oben verwiesen. Die Schutzkappe 3 gemäß den Fig. 5 und 6 entspricht ebenfalls im Wesentlichen der Schutzkappe 3 gemäß Fig. 2 und für gleiche oder ähnliche Bauteile werden einheitliche Bezugszeichen verwendet. In contrast to the embodiment according to FIG. 2, the sterile filter 5 according to FIGS. 3 and 4 is attached to a carrier layer 50. A material of the carrier layer 50 is chosen such that the carrier layer 50 gives the associated sterile filter 5 a higher mechanical strength. The carrier layer 50 is also made in advantageous embodiments of a hydrophilic material, so that a sufficient moisture release over the carrier layer 50 is ensured to the environment. In the illustrated embodiment, the carrier layer 50 is disposed on an outer side of the sterile filter 5 facing the environment. In other embodiments, the carrier layer 50 is arranged on an inner side 31 of the protective cap 3 facing inside of the sterile filter 5. Figures 5 and 6 show a discharge device 1 comprising a dispenser 2 according to FIG. 1 and a further embodiment of a protective cap 3 similar to FIG. 2 in a perspective overall view and a sectional view. For a description of the dispenser 2, see above. The protective cap 3 according to FIGS. 5 and 6 likewise substantially corresponds to the protective cap 3 according to FIG. 2 and identical reference numerals are used for identical or similar components.
Im Unterschied zu der Ausführungsform gemäß Fig. 2 weist die Schutzkappe 3 vier Belüftungsöffnungen 30 auf. In contrast to the embodiment according to FIG. 2, the protective cap 3 has four ventilation openings 30.
Wie oben beschrieben, ist in vorteilhaften Ausgestaltungen vorgesehen, dass der Sterilfilter 5 im aufgesetzten Zustand der Schutzkappe 3 eine der Austrittsöffnung 24 zugeordnete Spitze des Spenders 2 berührt. Um den Sterilfilter 5 in Kontakt mit der Spitze zu zwingen, weist die Schutzkappe 3 gemäß den Fig. 5 und 6 einen von der Innenseite des Deckelabschnitts 33 abragenden Anschlag 38 auf. Durch die Befestigung des Sterilfilters 5 mittels der Rastarme 37 und den Anschlag 38 wird eine freie Oberfläche des Sterilfilters 5 maximiert. Dadurch wird ein Absorbereffekt und ein Abtrocknen des Spenders mittels des Sterilfilters 5 optimiert. As described above, it is provided in advantageous embodiments that the sterile filter 5 in the attached state of the protective cap 3 touches a tip of the dispenser 2 assigned to the outlet opening 24. In order to force the sterile filter 5 into contact with the tip, the protective cap 3 according to FIGS. 5 and 6 has a stop 38 protruding from the inside of the lid portion 33. By attaching the sterile filter 5 by means of the latching arms 37 and the stop 38, a free surface of the sterile filter 5 is maximized. As a result, an absorber effect and a drying of the dispenser by means of the sterile filter 5 is optimized.
Um bei einer längerfristigen Lagerung, bei einer Lagerung in keimreicher Umgebung und/oder vor einem Erstgebrauch einen Keimeintrag und damit eine Belastung der Membran zu verringern, ist in einer Ausgestaltung vorgesehen, dass eine zusätzliche nicht dargestellte Überkappe über der Schutzkappe 3 angebracht wird. Für eine Befestigung dieser nicht dargestellten Überkappe weist die Schutzkappe 3 gemäß den Fig. 5 und 6 Aufnahmeöffnungen 39 auf. In order to reduce a microbial entry and thus a load on the membrane in the case of long-term storage, storage in a germ-rich environment and / or prior to first use, it is provided in one embodiment that an additional overcap (not shown) is attached over the protective cap 3. For attachment of this overcap, not shown, the cap 3 according to FIGS. 5 and 6 receiving openings 39.

Claims

Patentansprüche claims
1 . Schutzkappe für einen Spender (2) zum Austrag von pharmazeutischen und/oder kosmetischen Flüssigkeiten (4), wobei der Spender (2) 1 . Protective cap for a dispenser (2) for dispensing pharmaceutical and / or cosmetic liquids (4), the dispenser (2)
- ein Flüssigkeitsreservoir (21 ) und  - A liquid reservoir (21) and
- eine Austrittsöffnung (24), durch die hindurch die Flüssigkeit (4) in eine umgebende Atmosphäre abgegeben werden kann,  - An outlet opening (24) through which the liquid (4) can be discharged into a surrounding atmosphere,
aufweist, und  has, and
wobei die Schutzkappe (3) mindestens eine Belüftungsöffnung (30) zum Kommunizieren eines Innenraums mit einer äußeren Umgebung aufweist, dadurch gekennzeichnet, dass  the protective cap (3) having at least one ventilation opening (30) for communicating an interior space with an external environment, characterized in that
an der Schutzkappe (3) ein die mindestens eine Belüftungsöffnung (30) abdeckender Sterilfilter (5) angeordnet ist, um einen Keimeintrag über die mindestens eine Belüftungsöffnung (30) in den Innenraum der Schutzkappe (3) zu reduzieren oder zu verhindern.  a sterile filter (5) covering the at least one ventilation opening (30) is arranged on the protective cap (3) in order to reduce or prevent germ introduction via the at least one ventilation opening (30) into the interior of the protective cap (3).
2. Schutzkappe nach Anspruch 1 , dadurch gekennzeichnet, dass der Sterilfilter (5) einen mittleren Porendurchmesser oder eine Trenngrenze von maximal ca. 0,1 μηη bis ca. 0,3 μηη, vorzugsweise maximal ca. 0,2μηΊ aufweist. 2. Protection cap according to claim 1, characterized in that the sterile filter (5) has a mean pore diameter or a separation limit of at most about 0.1 μηη to about 0.3 μηη, preferably at most about 0.2μηΊ.
3. Schutzkappe nach Anspruch 2, dadurch gekennzeichnet, dass der Sterilfilter (5) als mikroporöse Polymermembran, vorzugsweise als mikroporöse hydrophile Polymermembran, aus einem Membranpolymer aus der Gruppe umfassend Polysulfon, Polyethersulfon, Cellulose, Cellulosederivate, Polyvinylidenfluorid, Polyamid, Polyester, und Polyacrylnitril und/oder Kombinationen davon ausgebildet ist. 3. Protection cap according to claim 2, characterized in that the sterile filter (5) as a microporous polymer membrane, preferably as a microporous hydrophilic polymer membrane, from a membrane polymer from the group comprising polysulfone, polyethersulfone, cellulose, cellulose derivatives, polyvinylidene fluoride, polyamide, polyester, and polyacrylonitrile and / or combinations thereof is formed.
4. Schutzkappe nach einem der Ansprüche 1 , 2 oder 3, dadurch gekennzeichnet, dass der Sterilfilter (5) mit einer Wandung der Schutzkappe (3) verrastet ist. 4. Protective cap according to one of claims 1, 2 or 3, characterized in that the sterile filter (5) with a wall of the protective cap (3) is latched.
5. Schutzkappe nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, dass die Schutzkappe (3) einen zylindrischen Abschnitt (32) und einen damit verbundenen Deckelabschnitt (33) umfasst, wobei die mindestens eine Belüftungsöffnung (30) an dem Deckelabschnitt (33) vorgesehen ist. 5. Protection cap according to one of claims 1 to 4, characterized in that the protective cap (3) comprises a cylindrical portion (32) and an associated cover portion (33), wherein the at least one ventilation opening (30) on the lid portion (33). is provided.
6. Schutzkappe nach Anspruch 5, dadurch gekennzeichnet, dass von einer Innenseite des Deckelabschnitts abragende Rastarme (37) zur Befestigung des Sterilfilters (5) vorgesehen sind. 6. Protective cap according to claim 5, characterized in that protruding from an inner side of the lid portion latching arms (37) for fixing the sterile filter (5) are provided.
7. Schutzkappe nach einem der Ansprüche 1 bis 6, dadurch gekennzeichnet, dass der Sterilfilter (5) auf einer Trägerschicht (50) aufgebracht ist. 7. Protection cap according to one of claims 1 to 6, characterized in that the sterile filter (5) is applied to a carrier layer (50).
8. Schutzkappe nach Anspruch 7, dadurch gekennzeichnet, dass eine gasdurchlässige, hydrophile Trägerschicht (50) vorgesehen ist. 8. Protective cap according to claim 7, characterized in that a gas-permeable, hydrophilic carrier layer (50) is provided.
9. Schutzkappe nach einem der Ansprüche 1 bis 8, dadurch gekennzeichnet, dass der Sterilfilter (5) derart angeordnet ist, dass er im Gebrauch eine Austrittsöffnung (24) des Spenders (2) kontaktiert, wobei insbesondere die Schutzkappe (3) einen Anschlag (38) aufweist, welche den Sterilfilter (5) im Gebrauch in Kontakt mit der Austrittsöffnung (24) zwingt. 9. Protection cap according to one of claims 1 to 8, characterized in that the sterile filter (5) is arranged such that it contacts in use an outlet opening (24) of the dispenser (2), wherein in particular the protective cap (3) has a stop ( 38) which forces the sterile filter (5) in use into contact with the outlet opening (24).
10. Austragvorrichtung umfassend einen Spender (2) zum Austrag von pharmazeutischen und/oder kosmetischen Flüssigkeiten (4) mit 10. Discharge device comprising a dispenser (2) for the discharge of pharmaceutical and / or cosmetic liquids (4) with
- einem Flüssigkeitsreservoir (21 ) und  - A liquid reservoir (21) and
- einer Austrittsöffnung (24), durch die hindurch die Flüssigkeit (4) in eine umgebende Atmosphäre abgegeben werden kann, und  - An outlet opening (24) through which the liquid (4) can be discharged into a surrounding atmosphere, and
eine Schutzkappe (3) nach einem der Ansprüche 1 bis 9, die mindestens eine Belüftungsöffnung (30) zum Kommunizieren eines Innenraums mit einer äußeren Umgebung aufweist, wobei an der Schutzkappe (3) ein die mindestens eine Belüftungsöffnung abdeckender Sterilfilter (5) angeordnet ist, um einen Keimeintrag über die mindestens eine Belüftungsöffnung in den Innenraum der Schutzkappe (3) zu reduzieren oder zu verhindern.  a protective cap (3) according to one of claims 1 to 9, which has at least one ventilation opening (30) for communicating an interior space with an external environment, wherein a sterile filter (5) covering the at least one ventilation opening is arranged on the protective cap (3), in order to reduce or prevent germ introduction via the at least one ventilation opening into the interior of the protective cap (3).
1 1 . Austragvorrichtung nach Anspruch 10, wobei der Spender (2) einen Auslasskanal (23), der das Flüssigkeitsreservoir (21 ) mit der Austrittsöffnung (24) verbindet, und ein druckabhängig öffnendes oder manuell betätigbares Auslassventil (25), welches im Auslasskanal (23) angeordnet ist und welches in einem geschlossenen Zustand den Auslasskanal (23) schließt, aufweist. 1 1. Dispensing apparatus according to claim 10, wherein the dispenser (2) has an outlet channel (23) connecting the liquid reservoir (21) to the outlet opening (24) and a pressure-responsive opening or manually operable outlet valve (25) disposed in the outlet channel (23) is and which in a closed state, the exhaust passage (23) closes.
EP14802906.9A 2013-12-17 2014-11-27 Protective cap for a dispenser, and dispenser for discharging pharmaceutical and/or cosmetic liquids Active EP3082707B1 (en)

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DE102013226253.1A DE102013226253B4 (en) 2013-12-17 2013-12-17 Protective cap for a dispenser and dispenser for dispensing pharmaceutical and / or cosmetic liquids
PCT/EP2014/075754 WO2015090887A1 (en) 2013-12-17 2014-11-27 Protective cap for a dispenser, and dispenser for discharging pharmaceutical and/or cosmetic liquids

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3082707B1 (en) 2013-12-17 2019-01-02 Aptar Radolfzell GmbH Protective cap for a dispenser, and dispenser for discharging pharmaceutical and/or cosmetic liquids

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011100450B8 (en) 2011-04-27 2013-10-17 Jörg Gerlach Apparatus for spraying cells, making the apparatus, method for spraying with the apparatus and a cell suspension sprayed with the apparatus
FR2988015B1 (en) * 2012-03-19 2015-12-11 Rexam Healthcare La Verpillier LIQUID DISPENSING DEVICE WITH REMOVABLE CAP
JP6537319B2 (en) * 2015-03-30 2019-07-03 東京ライト工業株式会社 cap
DE102016109612B4 (en) * 2016-05-25 2018-10-31 Gerresheimer Regensburg Gmbh Dispensing device for the metered delivery of a sterile fluid and a container for a sterile fluid
WO2017218549A1 (en) * 2016-06-14 2017-12-21 Renovacare Sciences Corp. Modular device for cell spraying
DE102016212892C5 (en) 2016-07-14 2020-01-30 F. Holzer Gmbh Pump head and dosing device
US10829276B2 (en) * 2017-02-01 2020-11-10 Silgan Dispensing Systems Hemer Gmbh Dispenser for a liquid
FR3067011B1 (en) * 2017-05-31 2019-08-02 Nemera La Verpilliere TIP AND DEVICE FOR DISPENSING LIQUID COMPRISING A CAP
US10933204B2 (en) * 2017-06-01 2021-03-02 Counteract, Llc Prescription bottle cap capable of administering opioid overdose reversal agent
IT201800002752A1 (en) * 2018-02-16 2019-08-16 Lameplast Spa CONTAINER, ESPECIALLY FOR MEDICAL, PHARMACEUTICAL, COSMETIC, FOOD OR SIMILAR PRODUCTS
FR3080844B1 (en) * 2018-05-07 2020-06-05 Horus Pharma PACKAGING AND DISPENSING DEVICE OF A PRODUCT WITH BOTTLE AND METERING CAP WITH FILTER
AU2019331886B2 (en) * 2018-08-31 2023-10-19 FUJIFILM Irvine Scientific, Inc. Venting system for a mixing apparatus
US20220040462A1 (en) * 2019-02-26 2022-02-10 3M Innovative Properties Company A system and method for prepping liquid
EP3730101A1 (en) 2019-04-26 2020-10-28 Aptar Radolfzell GmbH Vented protective cap for a liquid dispenser
CN111572988A (en) * 2020-05-19 2020-08-25 深圳市通产丽星科技集团有限公司 Packaging container
ES2952019T3 (en) * 2020-05-25 2023-10-26 Serve Sterile Pc Product with a non-alcoholic beverage and method of preserving said beverage

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3622049A (en) * 1969-05-05 1971-11-23 Schering Corp Dispensing system
JPS5811717Y2 (en) * 1979-04-09 1983-03-05 有限会社 コンペツクス breathable cap sheet
US4463880A (en) * 1982-04-30 1984-08-07 The Regents Of The University Of California Medicine drop dispenser with anti-bacterial filter
US4929354A (en) 1982-05-28 1990-05-29 Cuno, Incorporated Filter element having microporous membrane
DE3346692A1 (en) 1983-01-07 1984-07-19 Gelman Sciences, Inc., Ann Arbor, Mich. HAND-HELD FILTER AND DISPENSER FOR LIQUIDS
US4696409A (en) * 1986-06-13 1987-09-29 Caterpillar Inc. Vented fuel tank cap assembly
US4938389A (en) * 1988-11-03 1990-07-03 Eye Research Institute Of Retina Foundation Filter bottle
US4957518A (en) * 1989-06-06 1990-09-18 Brassell Gilbert W Assembly useful for retaining components such as a filter to a container and a corresponding combination
US5105993A (en) * 1989-12-29 1992-04-21 La Haye Laboratories, Inc. Disposable medical dispenser with a filtering dispenser nozzle
US5496471A (en) * 1990-01-08 1996-03-05 Ciba-Geigy Corporation Apparatus for removing components from solutions
US5080800A (en) * 1990-01-08 1992-01-14 Ciba-Geigy Corporation Process for removing components from solutions
US5033647A (en) * 1990-03-09 1991-07-23 Allergan, Inc. Value controlled squeezable fluid dispenser
US5154325A (en) * 1991-01-09 1992-10-13 Ryder International Corporation Solution delivery nozzle and system with antimicrobial features
US6000580A (en) 1992-06-03 1999-12-14 Astra Aktielbolag Device for dispensing preservative-free nasal sprays and similar preparations
SE9201718D0 (en) 1992-06-03 1992-06-03 Astra Ab NASAL SPRAY DEVICE
US5328063A (en) * 1993-06-10 1994-07-12 Creative Packaging Corp. Venting closure cap
US5437655A (en) * 1993-09-03 1995-08-01 B. Braun Medical Inc. Air inlet filter for burette top
US5849311A (en) * 1996-10-28 1998-12-15 Biopolymerix, Inc. Contact-killing non-leaching antimicrobial materials
US5869073A (en) * 1993-12-20 1999-02-09 Biopolymerix, Inc Antimicrobial liquid compositions and methods for using them
US5817325A (en) * 1996-10-28 1998-10-06 Biopolymerix, Inc. Contact-killing antimicrobial devices
US5611464A (en) * 1995-05-30 1997-03-18 Ciba Geigy Corporation Container for preserving media in the tip of a solution dispenser
FR2738555B1 (en) 1995-09-13 1998-08-21 Sofab IMPROVEMENTS TO A DISPENSING DEVICE FOR OPHTHALMOLOGICAL PRODUCTS
DE29518284U1 (en) * 1995-11-17 1996-02-08 Ursatec Verpackungs Gmbh Contamination protective dispenser for fluids
US6053368A (en) 1995-11-17 2000-04-25 Ursatec Verpackung-Gmbh Anti-contamination dispensing apparatus for fluids
US5988426A (en) * 1996-11-08 1999-11-23 Stern; Brett Leakproof vented beverage lid
FR2761665B1 (en) * 1997-04-02 1999-06-25 Sofab DEVICE FOR DISPENSING AND PACKAGING STERILE LIQUID PRODUCTS
FR2772007B1 (en) * 1997-12-08 2000-02-04 Sivel DEVICE FOR CONDITIONING AND DISPENSING A PRODUCT, WITH MANUAL PUMP AND CONTAINER WITH AIR INLET FILTER IN THE CONTAINER
WO1999040791A1 (en) * 1998-02-12 1999-08-19 Surfacine Development Company, Llc Disinfectant compositions providing sustained biocidal action
US7799009B2 (en) * 2000-01-24 2010-09-21 Bracco Diagnostics Inc. Tabletop drug dispensing vial access adapter
US6551608B2 (en) * 2000-03-06 2003-04-22 Porex Technologies Corporation Porous plastic media with antiviral or antimicrobial properties and processes for making the same
JP4580524B2 (en) * 2000-09-12 2010-11-17 株式会社日本点眼薬研究所 Discharge container with filter
FR2816600B1 (en) * 2000-11-13 2003-03-21 Michel Faurie DISPENSING DEVICE FOR DROP FLUID LIQUIDS
US6904929B2 (en) * 2001-06-26 2005-06-14 Filtertek Inc. Check valve and filter assembly incorporating such valve, especially for water cooler assemblies
US7011221B2 (en) * 2002-01-02 2006-03-14 Erie Plastics Corporation Anti-leak dust cover and closure used therewith
DE10200519A1 (en) * 2002-01-09 2003-07-10 Neomed Holding Sa Luxemburg Lu Valve
KR100660676B1 (en) 2002-04-04 2006-12-21 니프로 가부시키가이샤 Chemical container
JP4744775B2 (en) * 2002-11-20 2011-08-10 ニプロ株式会社 Chemical container
JP4047617B2 (en) * 2002-04-04 2008-02-13 ニプロ株式会社 Chemical container
DE20207474U1 (en) * 2002-05-13 2002-08-08 Dagn Josef Sealing cap, in particular for closing an oil filter connection
US20040129648A1 (en) * 2002-07-23 2004-07-08 Manesis Nick J. Antimicrobial matrix and method of use
WO2004089805A2 (en) * 2003-03-31 2004-10-21 Manesis Nick J Multi-dose liquid dispensing assembly
DE60303235T2 (en) * 2003-04-09 2006-09-28 Ursapharm Arzneimittel Gmbh & Co. Kg fluid dispenser
US8499985B2 (en) * 2003-05-28 2013-08-06 Robert A. Lehmkuhl Automatic dispensing cap for squeezable bottle
JP4615445B2 (en) * 2003-09-02 2011-01-19 大塚製薬株式会社 Discharge container and eye drop container
US20060011654A1 (en) * 2004-07-16 2006-01-19 Webb Garth T Disinfectant cap for sterile liquid dispenser
FR2873358B1 (en) * 2004-07-20 2006-11-10 Sivel Soc Civ Ile DEVICE FOR PACKAGING AND DISPENSING A PRODUCT WITH A STERILE FILTER BOTTLE WITH A TIP
US9004317B2 (en) * 2004-07-20 2015-04-14 Sivel Product packaging and dispensing device comprising a sterile filter bottle which is equipped with a nozzle
US8057567B2 (en) * 2004-11-05 2011-11-15 Donaldson Company, Inc. Filter medium and breather filter structure
US20100108712A1 (en) * 2005-09-30 2010-05-06 Manesis Nick J Multi-dose liquid dispensing assembly
EP1779933A1 (en) * 2005-10-26 2007-05-02 The Procter and Gamble Company Dispenser for a liquid
FR2897599B1 (en) * 2006-02-23 2010-08-27 Rexam Pharma LIQUID CONDITIONING AND DISPENSING ASSEMBLY.
US7628298B2 (en) * 2007-02-28 2009-12-08 Berry Plastics Corporation Aerosol overcap with evaporation vent
ITRM20070275A1 (en) * 2007-05-17 2008-11-18 Federighi Federigo MULTIDOSE DISPENSER BOTTLE FOR PRESERVATIVE-FREE LIQUID PREPARATIONS.
ATE556000T1 (en) * 2007-06-13 2012-05-15 M & R Consulting Services ELECTROCHEMICAL DISPENSER
JP5570753B2 (en) 2008-07-08 2014-08-13 株式会社ダイセル Filter material made of porous silica and cigarette filter using the same
FR2934572A1 (en) * 2008-07-31 2010-02-05 Thea Lab BOTTLE FOR FLASK OF LIQUID CONDITIONING TO DISPENSE DROP GOUTTE.
JPWO2010092938A1 (en) * 2009-02-16 2012-08-16 住友電工ファインポリマー株式会社 Porous multilayer filter and method for producing the same
US8523020B2 (en) * 2009-02-25 2013-09-03 Digital Innovations Llc Vented dispensing device
US20120104113A1 (en) * 2009-02-25 2012-05-03 Digital Innovations, Llc Vented Dispensing Device
GB201019769D0 (en) * 2010-11-22 2011-01-05 Greif Int Holding Bv Vented container closure
CN102079415B (en) * 2010-12-23 2012-09-05 蒋一新 Container for sucking beverage
DE102011086755A1 (en) 2011-11-21 2013-05-23 Aptar Radolfzell Gmbh Dispenser for dispensing pharmaceutical liquids
FR2988015B1 (en) 2012-03-19 2015-12-11 Rexam Healthcare La Verpillier LIQUID DISPENSING DEVICE WITH REMOVABLE CAP
DE102013211423A1 (en) * 2013-06-18 2014-12-31 Aptar Radolfzell Gmbh Multilayer container
DE102013226253B4 (en) 2013-12-17 2016-03-24 Aptar Radolfzell Gmbh Protective cap for a dispenser and dispenser for dispensing pharmaceutical and / or cosmetic liquids
US9669974B2 (en) * 2013-12-17 2017-06-06 Aptar Radolfzell Gmbh Protective cap for a dispenser, and discharge device for discharging pharmaceutical and/or cosmetical liquids
US9676525B2 (en) * 2013-12-17 2017-06-13 Aptar Radolfzell Gmbh Protective cap for a dispenser, and discharge device for discharging pharmaceutical and/or cosmetical liquids
DE102013226250B4 (en) * 2013-12-17 2019-07-18 Aptar Radolfzell Gmbh Protective cap for a dispenser and dispenser comprising a dispenser for dispensing pharmaceutical and / or cosmetic liquids
US10604420B2 (en) * 2013-12-18 2020-03-31 Brita Lp Method and apparatus for reservoir free and ventless water filtering
US20150360156A1 (en) * 2013-12-20 2015-12-17 Hollingsworth & Vose Company Filter media and elements with fine staple fibers
JP6453537B2 (en) * 2013-12-27 2019-01-16 日東電工株式会社 Moisture permeable filter media
FR3018704B1 (en) * 2014-03-20 2016-03-18 Rexam Healthcare La Verpillier LIQUID DISPENSING DEVICE COMPRISING A PROTECTIVE CAP.
US20150352809A1 (en) * 2014-06-06 2015-12-10 Milliken & Company Cementitious composite
US10351320B2 (en) * 2015-09-17 2019-07-16 Performance Systematix, Inc. Filter cap assembly including protective baffle and method of use
US10377539B2 (en) * 2015-09-17 2019-08-13 Performance Systematix, Inc. Filter cap assembly including protective baffle and method of use
DE102016210992B3 (en) * 2016-06-20 2017-05-11 Aptar Radolfzell Gmbh liquid dispenser

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3082707B1 (en) 2013-12-17 2019-01-02 Aptar Radolfzell GmbH Protective cap for a dispenser, and dispenser for discharging pharmaceutical and/or cosmetic liquids

Also Published As

Publication number Publication date
US11059639B2 (en) 2021-07-13
DE102013226253A1 (en) 2015-06-18
US20200262622A1 (en) 2020-08-20
CN105792791B (en) 2019-09-10
JP6515099B2 (en) 2019-05-15
EP3082707B1 (en) 2019-01-02
US20160311588A1 (en) 2016-10-27
JP2017507081A (en) 2017-03-16
WO2015090887A1 (en) 2015-06-25
CN105792791A (en) 2016-07-20
DE102013226253B4 (en) 2016-03-24

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