EP3042960A4 - Procédé de preparation d'ambreine - Google Patents
Procédé de preparation d'ambreine Download PDFInfo
- Publication number
- EP3042960A4 EP3042960A4 EP14842894.9A EP14842894A EP3042960A4 EP 3042960 A4 EP3042960 A4 EP 3042960A4 EP 14842894 A EP14842894 A EP 14842894A EP 3042960 A4 EP3042960 A4 EP 3042960A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- ambrein
- producing
- producing ambrein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- BIADSXOKHZFLSN-RMCJHQKMSA-N (1r,2r,4as,8as)-1-[(e)-6-[(1s)-2,2-dimethyl-6-methylidenecyclohexyl]-4-methylhex-3-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1h-naphthalen-2-ol Chemical compound C([C@@H]1[C@]2(CCCC(C)(C)[C@@H]2CC[C@]1(O)C)C)C\C=C(/C)CC[C@@H]1C(=C)CCCC1(C)C BIADSXOKHZFLSN-RMCJHQKMSA-N 0.000 title 1
- BIADSXOKHZFLSN-GCJBHHCISA-N Ambrein Natural products CC(=CCC[C@H]1[C@](C)(O)CC[C@H]2C(C)(C)CCC[C@]12C)CC[C@@H]3C(=C)CCCC3(C)C BIADSXOKHZFLSN-GCJBHHCISA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
- C12Y402/0313—Tetraprenyl-beta-curcumene synthase (4.2.3.130)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y504/00—Intramolecular transferases (5.4)
- C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
- C12Y504/99017—Squalene--hopene cyclase (5.4.99.17)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013184143 | 2013-09-05 | ||
PCT/JP2014/071333 WO2015033746A1 (fr) | 2013-09-05 | 2014-08-12 | Procédé de preparation d'ambreine |
Publications (3)
Publication Number | Publication Date |
---|---|
EP3042960A1 EP3042960A1 (fr) | 2016-07-13 |
EP3042960A4 true EP3042960A4 (fr) | 2017-01-25 |
EP3042960B1 EP3042960B1 (fr) | 2018-05-30 |
Family
ID=52628228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14842894.9A Active EP3042960B1 (fr) | 2013-09-05 | 2014-08-12 | Procédé de preparation d'ambreine |
Country Status (5)
Country | Link |
---|---|
US (1) | US9902979B2 (fr) |
EP (1) | EP3042960B1 (fr) |
JP (1) | JP6429243B2 (fr) |
CN (1) | CN105579585B (fr) |
WO (1) | WO2015033746A1 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201507170D0 (en) | 2015-04-24 | 2015-06-10 | Givaudan Sa | Process |
GB201507207D0 (en) | 2015-04-24 | 2015-06-10 | Givaudan Sa | Enzymes and applications thereof |
EP3441463B1 (fr) * | 2016-03-04 | 2021-04-28 | Niigata University | Cyclase tétraprényl-béta-curcumène de type mutant, et procédé de fabrication d'ambréine |
GB201618090D0 (en) | 2016-10-26 | 2016-12-07 | Givaudan Sa | Product |
JP7333913B2 (ja) * | 2017-09-01 | 2023-08-28 | 国立大学法人 新潟大学 | アンブレインの効率的製造方法 |
CN107828709B (zh) * | 2017-11-09 | 2021-06-25 | 天津大学 | 异源合成龙涎香醇的重组大肠杆菌及其构建方法 |
JP7053401B2 (ja) * | 2018-08-06 | 2022-04-12 | 株式会社デンソー | 新規環化物及び新規環化物の製造方法 |
WO2021005097A1 (fr) * | 2019-07-10 | 2021-01-14 | Firmenich Sa | Procédé biocatalytique pour la dégradation maîtrisée de composés terpéniques |
NL2024578B1 (en) * | 2019-12-24 | 2021-09-06 | Univ Delft Tech | Recombinant fungal cell |
WO2021133171A1 (fr) | 2019-12-24 | 2021-07-01 | Technische Universiteit Delft | Cellule fongique recombinante |
WO2021193806A1 (fr) * | 2020-03-25 | 2021-09-30 | 国立大学法人新潟大学 | TÉTRAPRÉNYL-β-CURCUMÈNE CYCLASE MUTANTE ET PROCÉDÉ DE PRÉPARATION D'AMBRÉINE À L'AIDE DE CETTE DERNIÈRE |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3819100B2 (ja) | 1997-02-21 | 2006-09-06 | 株式会社クラレ | 光学活性なアンブレインの製造方法および該製造方法に有用な中間体化合物並びに該中間体化合物の製造方法 |
BRPI0416912B1 (pt) * | 2003-11-26 | 2020-01-28 | Firmenich & Cie | método para a produção de patchoulol, método para preparar uma patchoulol sintase funcional variante, construção de ácido nucleico, vetor, método de obtenção de uma célula hospedeira recombinante, célula de microrganismo hospedeira, método de fabricação de uma patchoulol sintase |
US20160168595A1 (en) * | 2013-07-04 | 2016-06-16 | Antonius Cornelis Johannes Matheus JANSSEN | Two-phase fermentation process for the production of an organic compound |
-
2014
- 2014-08-12 CN CN201480046980.7A patent/CN105579585B/zh active Active
- 2014-08-12 US US14/916,216 patent/US9902979B2/en active Active
- 2014-08-12 WO PCT/JP2014/071333 patent/WO2015033746A1/fr active Application Filing
- 2014-08-12 EP EP14842894.9A patent/EP3042960B1/fr active Active
- 2014-08-12 JP JP2015535401A patent/JP6429243B2/ja active Active
Non-Patent Citations (1)
Title |
---|
FUJIWARA N ET AL: "New total synthesis of (+)-ambrein", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB, vol. 17, no. 21, 17 November 2006 (2006-11-17), pages 3037 - 3045, XP024962324, ISSN: 0957-4166, [retrieved on 20061117], DOI: 10.1016/J.TETASY.2006.11.015 * |
Also Published As
Publication number | Publication date |
---|---|
EP3042960A1 (fr) | 2016-07-13 |
CN105579585B (zh) | 2019-03-15 |
US20160304911A1 (en) | 2016-10-20 |
JPWO2015033746A1 (ja) | 2017-03-02 |
EP3042960B1 (fr) | 2018-05-30 |
CN105579585A (zh) | 2016-05-11 |
US9902979B2 (en) | 2018-02-27 |
JP6429243B2 (ja) | 2018-11-28 |
WO2015033746A1 (fr) | 2015-03-12 |
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