EP3022533A1 - Particle-dosing device - Google Patents

Particle-dosing device

Info

Publication number
EP3022533A1
EP3022533A1 EP14767109.3A EP14767109A EP3022533A1 EP 3022533 A1 EP3022533 A1 EP 3022533A1 EP 14767109 A EP14767109 A EP 14767109A EP 3022533 A1 EP3022533 A1 EP 3022533A1
Authority
EP
European Patent Office
Prior art keywords
particles
reservoir
dosing
transfer
tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14767109.3A
Other languages
German (de)
French (fr)
Inventor
Vincent Boudy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Assistance Publique Hopitaux de Paris APHP
Original Assignee
Assistance Publique Hopitaux de Paris APHP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Assistance Publique Hopitaux de Paris APHP filed Critical Assistance Publique Hopitaux de Paris APHP
Publication of EP3022533A1 publication Critical patent/EP3022533A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/003—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it for fluent solid material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B1/04—Methods of, or means for, filling the material into the containers or receptacles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/021—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
    • G01F11/025—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type with manually operated pistons
    • G01F11/027—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type with manually operated pistons of the syringe type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0053—Syringes, pipettes or oral dispensers

Definitions

  • the present invention relates to a particle dosing device, in particular for drugs in the form of microspheres.
  • particuies here means grains whose size is between 1 micron and 2 millimeters. These particles may therefore in particular be in the form of powder such as microspheres.
  • drugs in aqueous form are more unstable on biological and chemical pian than drugs in dry form.
  • a dispenser comprising a reservoir for the particles, closed by a complementary piece ensuring both the dosage and the distribution of the particles.
  • this complementary piece comprises a syringe type element with a cylindrical portion, in which laqueie can be inserted a piston. Moreover, this cylindrical portion has in its lower part, a spout.
  • the piston itself comprises two parts: a tube in which a rod is ciipsé, adapted to the quantity of product to be dosed.
  • the syringe-type element makes it possible to dose a quantity of product, thanks to the piston which is adapted to this specific quantity.
  • This device makes it possible to efficiently dose the drugs, but its use is relatively complex.
  • the complementary piece closing the container can be easily removed by the user. This entails risks of contamination of the particles present in the container.
  • the object of the invention is to overcome these disadvantages by proposing a particle dispenser whose use is simplified, which makes it possible to protect the particles from the risks of contamination and using fewer elements.
  • the invention relates to a device for measuring particles, in particular drugs in the form of microspheres, comprising:
  • a reservoir for particles comprising an orifice and means for closing this orifice
  • syringe type dosing means comprising a tube and a piston slidably mounted in the tube, these means being removably attached to the reservoir at the orifice and
  • the transfer or closure means are operable by a user to allow the particles to leave the tank.
  • the closing means and the transfer means are independent.
  • closure and transfer means are common and include in particular a worm.
  • the tube and the transfer means comprise each complementary connection means capable of cooperating with each other.
  • the reservoir has a flared shape since its opening, to facilitate the flow of particles .:
  • the reservoir has a complementary opening for filling with particles.
  • the closing means and or transfer advantageously comprise a security system.
  • the tub of the dosing means is preferably graduated.
  • the dosing means are preferably for single use.
  • FIG. 1 is a partial sectional side view of the measuring device according to the invention, illustrating the container and the syringe-type element attached to the container,
  • FIG. 2 illustrates the device of FIG. 1 during the dosage of the drug
  • FIG. 3 illustrates the device of FIG. 1 with the syringe element detached from the container.
  • Figure 1 illustrates the metering device according to the invention in its metering position.
  • the device comprises a reservoir 1 which is filled with particles 3,
  • the container 1 comprises an orifice 10 through which the particles 3 can flow and, in the extension of the orifice, transfer means 12,
  • the transfer means here consist of a cylindrical portion 120 in which is placed a worm 121 which can be actuated by a knob 122.
  • the particles can only exit the container 1 to the extent that an action is performed by the user, in this case the rotation of the wheel 122. In other words, in the absence action of the user, the particles 3 are blocked by the worm.
  • the transfer means thus fulfills both the function of closing the container 1 and transferring the particles from the inside to the outside of the container 1.
  • closure By means of closure there is understood here a means which prevents the particles from leaving the container, without necessarily having the container sealed.
  • the device also comprises dosing means 2.
  • dosing means 2 are of the syringe type and comprise a tube 20 and a piston 21 slidably mounted in the tube 20.
  • the outer surface of the tube 20 preferably has a graduation 200.
  • the syringe-type element is fixed at the free end 123 of the tube 120.
  • This attachment can be provided by various means, including clipping or screwing.
  • Figure 2 illustrates the device according to the invention during the dosage of the drug.
  • the user turns the wheel 122 to actuate the worm 121 and thus cause the passage of the particles in the cylindrical portion 120 until they reach the inner end 210 of the piston 21.
  • the user actuates the wheel 122 in rotation and the piston 2 in translation until the pisto 21 reaches the desired level in the graduation and the . tube 20 is filled with particles 3 above this graduation.
  • the user can then administer the dose of medication.
  • the particles are retained in the transfer means 12, thanks to the worm.
  • the means 2 may be discarded if they are for single use. They can also be fixed again on the container 1, for a new use.
  • the container 1 has a beveled portion 11 around the opening 10. With this flared shape since Opening IC the container facilitates the flow of particles to the orifice 10 and the transfer means 12,
  • the container is supplied filled with particles. So, I container is thrown once empty.
  • the container 1 has an opening for filling.
  • a desiccant can be placed in the container 1.
  • the container can be made of a plastic material having desiccant properties. This improves the storage of the drug.
  • the transfer means since the transfer means must be actuated by a user to allow the particles to exit the reservoir, it is possible to effectively measure the doses of drug to be delivered.
  • the invention is not limited to this embodiment of the transfer means.
  • closure means can be actuated by a user to allow passage of particles or, on the contrary, block it.
  • the closing means of the recipient and the particle transfer means are independent of each other.
  • a security system may also be provided to prevent inappropriate use of the metering device.
  • This safety system may for example be provided at the wheel 122 or at the level of the closure element when it is provided.
  • This security system is not illustrated in the figures. Conventionally, it requires the user to perform two movements in a coordinated manner to allow here either the actuation of the wheel or the opening of a valve for example.
  • means may be provided to make the container and therefore the dosing device inviolable, that is to say whose opening is visible.

Abstract

The invention relates to a device for dosing particles, especially medicaments in the form of microspheres, comprising: a store (1) for the particles (3), comprising an opening (10) and means for closing said opening; syringe-type dosing means (2) comprising a tube (20) and a piston (21) which is slidably mounted in the tube, said means being detachably fixed to the store, at the opening; and means (12) for transferring particles between the opening (10) of the store and the dosing means (2), which are an integral part of the store, the dosing means (2) being independent from the transfer means. The invention is characterised in that the transfer means can be actuated by a user in order to allow the particles to leave the store.

Description

DISPOSITIF DOSEUR DE PARTICULES.  PARTICLE DOSE DEVICE.
La présente invention concerne un dispositif doseur de particules, notamment destiné à des médicaments se présentant sous forme de microsphères. The present invention relates to a particle dosing device, in particular for drugs in the form of microspheres.
On entend ici par « particuies », des grains dont la taille est comprise entre 1 micron et 2 millimètres. Ces particules peuvent donc notamment se présenter sous forme de poudre comme de microsphères.  The term "particuies" here means grains whose size is between 1 micron and 2 millimeters. These particles may therefore in particular be in the form of powder such as microspheres.
D manière générale, les médicaments se présentant sous forme aqueuse sont plus instables sur ie pian biologique et chimique que des médicaments sous forme sèche.  In general, drugs in aqueous form are more unstable on biological and chemical pian than drugs in dry form.
Ainsi, la stabilité de ces derniers est assurée sans qui! soit nécessaire de prévoir des conservateurs.  Thus, the stability of these is assured without whom! it is necessary to provide conservators.
De nombreux dispositifs ont déjà été proposés pour assurer le dosage de produits se présentant sous forme de particules.  Many devices have already been proposed to ensure the dosage of products in the form of particles.
On connaît par exemple un doseur comprenant un réservoir pour les particules, fermé par une pièce complémentaire assurant à la fois le dosage et la distribution des particules.  For example, there is known a dispenser comprising a reservoir for the particles, closed by a complementary piece ensuring both the dosage and the distribution of the particles.
A cet effet, cette pièce complémentaire comporte un élément du type seringue avec une partie cylindrique, dans laqueie peut être inséré un piston. Par ailleurs, cette partie cylindrique comporte dans sa partie basse, un bec verseur.  For this purpose, this complementary piece comprises a syringe type element with a cylindrical portion, in which laqueie can be inserted a piston. Moreover, this cylindrical portion has in its lower part, a spout.
Le piston comporte lui-même deux parties : un tube dans lequel est ciipsé une tige, adaptée à la quantité de produit à doser.  The piston itself comprises two parts: a tube in which a rod is ciipsé, adapted to the quantity of product to be dosed.
Ainsi, l'élément de type seringue permet de doser une quantité de produit, grâce au piston qui est adapté à cette quantité spécifique.  Thus, the syringe-type element makes it possible to dose a quantity of product, thanks to the piston which is adapted to this specific quantity.
Ainsi, si le dispositif doit pouvoir être utilisé pour doser quatre quantités différentes de particuies, il est nécessaire de disposer de quatre tiges différentes pour le piston.  Thus, if the device must be able to be used to dose four different amounts of particles, it is necessary to have four different rods for the piston.
Par ailleurs, ia mesure d'une dose de médicament nécessite plusieurs opérations successives, une fois que la tige du piston a été choisie et que le piston a été inséré dans la partie cylindrique : - tourner le piston de manière à libérer le passage entre le réservoir et ia partie cylindrique, In addition, the measurement of a dose of medicament requires several successive operations, once the piston rod has been chosen and the piston has been inserted into the cylindrical portion: turn the piston so as to release the passage between the reservoir and the cylindrical portion,
- tourner le dispositif pour que ie réservoir se trouve au-dessus de l'élément du type seringue et que les granules puissent tomber par s gravité dans l'élément d type seringue,  rotating the device so that the reservoir is above the syringe-type element and the granules can fall by gravity into the syringe element,
- tourner le piston pour bloquer le passage entre le récipient et l'élément de type seringue,  - turn the piston to block the passage between the container and the syringe type element,
- retourner le dispositif et enfin,  - return the device and finally,
- tourner de nouveau le piston pour libérer le passage entre celui-ci et le io bec verseur et permettre la libération de la dose de médicament.  - turn the piston again to release the passage between it and the spout and allow the release of the drug dose.
Ce dispositif permet de doser efficacement les médicaments mats son utilisation est relativement complexe.  This device makes it possible to efficiently dose the drugs, but its use is relatively complex.
E effet, il nécessite d'avoir à disposition une pluralité de pistons, ce nombre correspondant au nombr de dosages pouvant être ! 5 assurés par le dispositif.  Indeed, it requires to have available a plurality of pistons, this number corresponding to the number of dosages that can be! 5 insured by the device.
De plus, la préparation d'une dose de médicament nécessite de nombreuses manipulations qui sont fastidieuses pour l'utilisateur.  In addition, the preparation of a dose of medication requires many manipulations that are tedious for the user.
Par ailleurs, la pièce complémentaire fermant le récipient peut en être facilement retirée par l'utilisateur. Ceci entraîne des risques de0 contamination des particules présentes dans le récipient.  Furthermore, the complementary piece closing the container can be easily removed by the user. This entails risks of contamination of the particles present in the container.
■Celles-ci peuvent également être contaminées du fait que des particules précédemment dosées peuvent ne pas être distribuées mais au eontraire, rester dans l'élément de type seringu et retourner dans le récipient après dosage. ■ They can also be contaminated because of the previously dosed particles may not be distributed but eontraire, seringu stay in the type of item and return to the vessel after dosing.
5 L'invention a pour objet de pallier ces inconvénients en proposant un doseur pour particules dont l'utilisation est simplifiée, qui permet de protéger les particules des risques de contamination et mettant en œuvre moins d'éléments. The object of the invention is to overcome these disadvantages by proposing a particle dispenser whose use is simplified, which makes it possible to protect the particles from the risks of contamination and using fewer elements.
Ainsi, l'invention concerne un dispositif doseur de particules,0 notamment de médicaments sous forme de microsphères, comprenant :  Thus, the invention relates to a device for measuring particles, in particular drugs in the form of microspheres, comprising:
- un réservoir pour les particules comprenant un orifice et des moyens de fermeture de cet orifice, - des moyens de dosage du type seringue comportant un tube et un piston monté coulissant dans 1e tube, ces moyens étant fixés de manière amovible au réservoir au niveau de l'orifice et a reservoir for particles comprising an orifice and means for closing this orifice, syringe type dosing means comprising a tube and a piston slidably mounted in the tube, these means being removably attached to the reservoir at the orifice and
- des moyens de transfert des particules entre l'orifice' du réservoir et les 5 moyens de dosage, qui sont partie intégrante du réservoir, les moyens de dosage étant indépendants des moyens de transfert. - the particle transfer means between the orifice 'of the reservoir 5 and the metering means, which are an integral part of the reservoir, the metering means being independent of the transfer means.
Selon l'invention, les moyens d transfert ou de fermeture sont actionnables par un utilisateur pour permettre aux particule de sortir du réservoir.  According to the invention, the transfer or closure means are operable by a user to allow the particles to leave the tank.
o Dans une première variante, les moyens de fermeture et les moyens de transfert sont indépendants. In a first variant, the closing means and the transfer means are independent.
Dans une deuxième variante, îes moyens de fermeture et de transfert sont communs et comprennent notamment une vis sans fin.  In a second variant, the closure and transfer means are common and include in particular a worm.
De faço préférée, le tube et tes moyens de transfert s comportent chacu des moyens de connexion complémentaires susceptibles de coopérer entre eux.  Preferably, the tube and the transfer means comprise each complementary connection means capable of cooperating with each other.
De manière avantageuse, te réservoir présente une forme évasée depuis son ouverture, pour faciliter l'écoulement des particules.:  Advantageously, the reservoir has a flared shape since its opening, to facilitate the flow of particles .:
D façon préférée, le réservoir comporte une ouverture o complémentaire pour son remplissage avec des particules.  Preferably, the reservoir has a complementary opening for filling with particles.
Pour éviter l'utilisatio inappropriée du dispositif doseur, notamment par des enfants, tes moyens de fermetur et ou de transfert comportent avantageusement un système de sécurité.  To avoid the inappropriate use of the dosing device, especially by children, the closing means and or transfer advantageously comprise a security system.
Pour faciliter le dosage des particules, le tub des moyens de s dosage est de préférence gradué.  In order to facilitate the determination of the particles, the tub of the dosing means is preferably graduated.
Enfin, les moyens de dosage sont de préférence à usage unique.  Finally, the dosing means are preferably for single use.
L'invention sera mieux comprise et d'autres buts, caractéristiques et avantages de celle-ci apparaîtront plus clairement' à la o lecture de la description qui suit et qui est faste au regard des dessins annexés sur les uels : - ta figure 1 est une vue de côté en coupe partiell du dispositif doseur selon l'invention, illustrant le récipient et l'élément de type seringue fixé sur le récipient, The invention will be better understood and other objects, features and advantages thereof will appear more clearly 'the o reading the description which follows and which is auspicious to the attached drawings on ual: FIG. 1 is a partial sectional side view of the measuring device according to the invention, illustrating the container and the syringe-type element attached to the container,
- la figure 2 illustre le dispositif de la figure 1 lors du dosage du médicament, et  FIG. 2 illustrates the device of FIG. 1 during the dosage of the drug, and
- îa figure 3 illustre 1e dispositif de la figure 1 avec l'élément de type seringue détaché du récipient.  FIG. 3 illustrates the device of FIG. 1 with the syringe element detached from the container.
Les éléments communs aux différentes figures seront désignés par les mêmes références.  The elements common to the different figures will be designated by the same references.
La figure 1 illustre le dispositif doseur selon l'invention dans sa position de dosage.  Figure 1 illustrates the metering device according to the invention in its metering position.
Le dispositif comprend un réservoir 1 qui est rempli de particules 3,  The device comprises a reservoir 1 which is filled with particles 3,
Le récipient 1 comporte un orifice 10 par lequel tes particules 3 peuvent s'écoule et, dans le prolongement de l'orifice, des moyens de transfert 12,  The container 1 comprises an orifice 10 through which the particles 3 can flow and, in the extension of the orifice, transfer means 12,
Les moyens de transfert sont ici constitués par une partie cylindrique 120 dans laquelle est placée une vis sans fin 121 qui peut être actionnée par une molette 122.  The transfer means here consist of a cylindrical portion 120 in which is placed a worm 121 which can be actuated by a knob 122.
Avec de tels moyens de transfert, les particules ne peuvent sortir du récipient 1 que dans la mesure où une action est effectuée par l'utilisateur, en l'occurrence la rotation de la molette 122. En d'autres termes, en l'absence d'action de l'utilisateur, les particules 3 sont bloquées par la vis sans fin.  With such transfer means, the particles can only exit the container 1 to the extent that an action is performed by the user, in this case the rotation of the wheel 122. In other words, in the absence action of the user, the particles 3 are blocked by the worm.
Dans ce mode de réalisation, le moyen de transfert remplit donc à la fois la fonction de fermeture du récipient 1 et de transfert des particules depuis l'intérieur vers l'extérieur du récipient 1 .  In this embodiment, the transfer means thus fulfills both the function of closing the container 1 and transferring the particles from the inside to the outside of the container 1.
On comprend ici par moyen de fermeture, un moyen qui empêche les particules de sortir du récipient, sans nécessairement que te récipient soit étanche.  By means of closure there is understood here a means which prevents the particles from leaving the container, without necessarily having the container sealed.
te dispositif comprend également des moyens de dosage 2. Ces moyens 2 sont du type seringue et comportent un tube 20 et un piston 21 monté coulissant dans le tube 20. the device also comprises dosing means 2. These means 2 are of the syringe type and comprise a tube 20 and a piston 21 slidably mounted in the tube 20.
Comme l'illustre la figure 1 , la surface extérieure du tube 20 comporte de préférence une graduation 200.  As illustrated in Figure 1, the outer surface of the tube 20 preferably has a graduation 200.
Dans la position illustrée à la figure 1 , l'élément de type seringue est fixé au niveau de l'extrémité' libre 123 du tube 120.  In the position illustrated in FIG. 1, the syringe-type element is fixed at the free end 123 of the tube 120.
Cette fixation peut êtr assurée par divers moyens, notamment par clipsage ou par vissage.  This attachment can be provided by various means, including clipping or screwing.
La figure 2 illustre le dispositif selon l'invention lors du dosage du médicament.  Figure 2 illustrates the device according to the invention during the dosage of the drug.
Lors de cette opération, l'utilisateur tourne la molette 122 pour actionner la vis sans fin 121 et ainsi provoquer le passage des particules dans la partie cylindrique 120 jusqu'à ce qu'elles atteignent l'extrémité intérieure 210 du piston 21.  During this operation, the user turns the wheel 122 to actuate the worm 121 and thus cause the passage of the particles in the cylindrical portion 120 until they reach the inner end 210 of the piston 21.
L'utilisateur tire alors sur l'extrémité extérieure 211 du piston pour le faire coulisser dans fe tube 20.  The user then pulls on the outer end 211 of the piston to slide it into the tube 20.
L'utilisateur actionne la molette 122 en rotation et ie piston 2 en translation jusqu'à ce que le pisto 21 atteigne le niveau souhaité dans la graduation eî que le. tube 20 soit rempli de particules 3 au-dessus de cette graduation. The user actuates the wheel 122 in rotation and the piston 2 in translation until the pisto 21 reaches the desired level in the graduation and the . tube 20 is filled with particles 3 above this graduation.
Une fois que la dose souhaitée de médicament est présente dans le moyen de dosage 2, celui-ci est détaché du récipient. Ceci est illustré à la figure 3.  Once the desired dose of drug is present in the dosage means 2, it is detached from the container. This is illustrated in Figure 3.
L'utilisateur peut alors administrer la dose de médicament. The user can then administer the dose of medication.
Par ailleurs, au niveau du récipient 1, les particules sont retenues dans le moyen de transfert 12, grâce à la vis sans fin. Moreover, at the level of the container 1, the particles are retained in the transfer means 12, thanks to the worm.
Lorsque le médicament a été administré, les moyens 2 peuvent être jetés s'ils sont à usage unique. Ils peuvent également être fixés de nouveau sur le récipient 1 , en vue d'une nouvelle utilisation.  When the drug has been administered, the means 2 may be discarded if they are for single use. They can also be fixed again on the container 1, for a new use.
Les différentes figures montrent que le récipient 1 comporte une partie biseautée 11 autour de l'ouverture 10. Grâce à cette forme évasée depuis l'Ouverture IC le récipient facilite l'écoulement des particules vers l'orifice 10 et le moyen de transfert 12, The various figures show that the container 1 has a beveled portion 11 around the opening 10. With this flared shape since Opening IC the container facilitates the flow of particles to the orifice 10 and the transfer means 12,
Par ailleurs, dans l'exemple illustré, le récipient est fourni rempli de particules. Ainsi, je récipient est jeté une fois vide.  On the other hand, in the illustrated example, the container is supplied filled with particles. So, I container is thrown once empty.
5 On peut cependant prévoir que le récipient 1 présente une ouverture permettant son remplissage.  However, it can be provided that the container 1 has an opening for filling.
Par ailleurs, on peut placer une capsule déshydratante dans le récipient 1. En alternative, le récipient peut être réalisé en un matériau plastique ayant des propriétés déshydratantes. Ceci permet d'améliorer la i o conservation du médicament.  Furthermore, a desiccant can be placed in the container 1. Alternatively, the container can be made of a plastic material having desiccant properties. This improves the storage of the drug.
Lé fonctionnement qui vient d'êtr décrit en référence au figures 1 à 3 montre que le. dispositif selon l'invention est d'une utilisation très simple.  The operation which has just been described with reference to FIGS. 1 to 3 shows that the. device according to the invention is of a very simple use.
Par ailleurs, il évite que la manipulation des moyens de 15 dosage conduise à ouvrir le récipient. Ainsi, les risques de contamination des particules présentes dans le récipient sont évités. Cet effet est obtenu grâce à l'indépendance entr les moyens de transfert, et les moyens de dosage. Ces derniers sont indépendants du réservoir, alors que les moyens de transfert sont partie intégrante du réservoir. Furthermore, it prevents the manipulation of the metering means to open the container. Thus, the risks of contamination of the particles present in the container are avoided. This effect is obtained thanks to the independence between the transfer means and the dosing means. These are independent of the tank, while the transfer means are integral part of the tank.
0 Par ailleurs, l'utilisation d'une vis sans fin, au niveau des moyens de transfert, évite les risques de rétroeontamina ion. En effet, grâce à cette vis sans fin, aucune particule dosée dans ies moyens de dosage n'est susceptible de retourner dans ie récipient. Furthermore, the use of an endless screw, at the level of the transfer means, avoids the risks of retrocontamination. Indeed, thanks to this worm, no particle assayed in the dosing means is likely to return to the container.
Ainsi, dans la mesure où les moyens de transfert doivent être5 actionnés par un utilisateur pour permettre aux particules de sortir du réservoir, il est possible de mesurer efficacement les doses de médicament à délivrer.  Thus, since the transfer means must be actuated by a user to allow the particles to exit the reservoir, it is possible to effectively measure the doses of drug to be delivered.
Cependant, l'invention n'est pas limitée à ce mode de réalisation des moyens de transfert. However, the invention is not limited to this embodiment of the transfer means.
0 Ceux-ci peuvent également être constitués uniquement par l'élément cylindrique 120. Il est alors nécessaire de prévoir des moyens de fermeture, au niveau de l'orifice 10 ou entre l'orifice et extrémité libre 123 de (a. partie cylindrique 120, comme le clapet 124. These can also be constituted solely by the cylindrical element 120. It is then necessary to provide means of closing, at the orifice 10 or between the orifice and free end 123 of (a) cylindrical portion 120, as the valve 124.
Ces moyens de fermeture peuvent être actionnés par un utilisateur pour permettre Je passage de particules ou, au contraire, le bloquer.  These closure means can be actuated by a user to allow passage of particles or, on the contrary, block it.
Dans cet autre mode de réalisation, on peut également prévoir un rampe à l'intérieur de la partie cylindrique 120 afin de contrôler ou ralentir l'écoulement des particules du fait de la gravité.  In this other embodiment, it is also possible to provide a ramp inside the cylindrical portion 120 in order to control or slow down the flow of particles due to gravity.
On comprend que, dans ce mode de réalisation et ses variantes, les moyens de fermeture du récipien et les moyens de transfert des particuies sont indépendants les uns des autres.  It is understood that, in this embodiment and its variants, the closing means of the recipient and the particle transfer means are independent of each other.
Dans tous les modes de réalisation envisagés, la protection et la conservation des produits pulvérulents contenus dans se réservoir sont assurées.  In all the embodiments envisaged, the protection and preservation of the powdery products contained in the reservoir are ensured.
Un système de sécurité peut également être prévu pour éviter une utilisation inappropriée du dispositif doseur.  A security system may also be provided to prevent inappropriate use of the metering device.
Ce système de sécurité peut par exemple être prévu au niveau de ia molette 122 ou encore au niveau de l'élément de fermeture lorsque celui-ci est prévu.  This safety system may for example be provided at the wheel 122 or at the level of the closure element when it is provided.
Ce système de sécurité n'est pas illustré sur les figures. De façon classique, il oblige l'utilisateur à effectuer deux mouvements de façon coordonnée pour permettre ici soit S'actîonnement de la molette, soit l'ouverture d'un clapet par exemple.  This security system is not illustrated in the figures. Conventionally, it requires the user to perform two movements in a coordinated manner to allow here either the actuation of the wheel or the opening of a valve for example.
Par ailleurs, des moyens peuvent être prévus pour rendre le récipient et donc le dispositif doseur inviolable, c'est-à-dire dont l'ouverture est visible.  Moreover, means may be provided to make the container and therefore the dosing device inviolable, that is to say whose opening is visible.
Les signes de référence insérés après les caractéristiques techniques figurant dans les revendications ont pour seul but de faciliter la compréhension de ces dernières et ne sauraient en limiter îa portée.  The reference signs inserted after the technical characteristics appearing in the claims are only intended to facilitate the understanding of the latter and can not limit its scope.

Claims

REVENDICATIONS
1. Dispositif doseur de particules, notamment de médicaments sous forme de microsphères, comprenant : A device for metering particles, in particular medicaments in the form of microspheres, comprising:
- un réservoir (1) pour tes particules (2) comprenan un orifice (10) et des moyens de fermeture de cet orifice,  a reservoir (1) for particles (2) comprising an orifice (10) and means for closing this orifice,
- des moyens de dosage (2) du type seringue comportant un tube (20) et un piston (21) monté coulissant dans le tube, ces moyens étant fixés de manière amovible au réservoir au niveau de l'orifice, et - metering means (2) of the syringe type having a tube (20) and a piston (21) slidably mounted in the tube, said means being removably attached to the tank at the orifice, and
- des moyens d transfert (12) des particules entre l'orifice (10) du réservoir et les moyens (2) de dosage, qui sont partie intégrante du réservoir, les moyens (2) de dosage étant indépendants des moyens de transfert, caractérisé en ce que les moyens de transfert sont actionnâmes par un utilisateur pour permettre aux particuies de sortir du réservoir.  - Means for transferring (12) the particles between the orifice (10) of the reservoir and the metering means (2), which are integral parts of the reservoir, the metering means (2) being independent of the transfer means, characterized in that the transfer means are actuated by a user to allow the particles to exit the reservoir.
2. Dispositif doseur selon la revendication 1, caractérisé en ce que les moyens de fermeture et ies moyens de transfert sont indépendants,  2. Measuring device according to claim 1, characterized in that the closure means and the transfer means are independent,
3. Dispositif doseur selon fa revendication , caractérisé e ce que les moyens de fermeture et de transfert sont communs.  3. Measuring device according to claim, characterized in that the closing means and transfer are common.
4. Dispositif doseur selon i'une des revendications 1 à 3, caractérisé en ce que le tube (20) et ies moyens (12) de transfert comportent chacun des moyens de connexio complémentaires susceptibles de coopérer entre eux,  4. Measuring device according to one of claims 1 to 3, characterized in that the tube (20) and the means (12) for transfer each comprise complementary connecting means capable of cooperating with each other,
5. Dispositif doseur selon Tune des revendications 1 à 4, caraciérisé en ce que le réservoir (1) présente une forme évasée depuis son ouverture (10).  5. Measuring device according to one of claims 1 to 4, caracterized in that the reservoir (1) has a flared shape since its opening (10).
8. Dispositif doseur seion l'une des revendications 1 à 5, caractérisé en ce que le réservoir comporte une ouverture complémentaire pour son remplissage avec des particules.  8. Measuring device according to one of claims 1 to 5, characterized in that the reservoir comprises a complementary opening for filling with particles.
7, Dispositif doseur selon l'une des revendications 1 à 8, caractérisé en ce que les moyens d fermeture et ou de transfert comportent un système de sécurité. 8, Dispositif doseur selon l'une de revendication 1 à 7. caractérisé en ce que le tube (20) des moyens de dosage est gradué. 7, dosing device according to one of claims 1 to 8, characterized in that the closing means and or transfer comprise a security system. 8, dosing device according to one of claims 1 to 7. characterized in that the tube (20) of the dosing means is graduated.
9. Dispositif doseur selo i'une de revendication 1 à 8, caractérisé en ce que les moyens d dosage sont à usage unique. 9. Metering device selo i one of claim 1 to 8, characterized in that the means of dosing are disposable.
EP14767109.3A 2013-07-17 2014-07-16 Particle-dosing device Withdrawn EP3022533A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1357012A FR3008610B1 (en) 2013-07-17 2013-07-17 PARTICLE DOSE DEVICE.
PCT/IB2014/063157 WO2015008239A1 (en) 2013-07-17 2014-07-16 Particle-dosing device

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EP3022533A1 true EP3022533A1 (en) 2016-05-25

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EP (1) EP3022533A1 (en)
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WO (1) WO2015008239A1 (en)

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FR3008610A1 (en) 2015-01-23
US20160143812A1 (en) 2016-05-26
WO2015008239A1 (en) 2015-01-22
FR3008610B1 (en) 2018-03-30

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