EP3019168A1 - Losmapimod for use in treating glomerular disease - Google Patents

Losmapimod for use in treating glomerular disease

Info

Publication number
EP3019168A1
EP3019168A1 EP14735983.0A EP14735983A EP3019168A1 EP 3019168 A1 EP3019168 A1 EP 3019168A1 EP 14735983 A EP14735983 A EP 14735983A EP 3019168 A1 EP3019168 A1 EP 3019168A1
Authority
EP
European Patent Office
Prior art keywords
glomerular disease
nicotinamide
cyclopropylcarbamoyl
dimethylpropyl
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14735983.0A
Other languages
German (de)
English (en)
French (fr)
Inventor
Dennis SPRECHER
Robert Nicholas Willette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Intellectual Property No 2 Ltd
Original Assignee
GlaxoSmithKline Intellectual Property No 2 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GlaxoSmithKline Intellectual Property No 2 Ltd filed Critical GlaxoSmithKline Intellectual Property No 2 Ltd
Publication of EP3019168A1 publication Critical patent/EP3019168A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Definitions

  • the present invention also provides for a method for treating a glomerular disease in a subject in need thereof which comprises administering the compound 6-(5- cyclopropylcarbamoyl-3-fluoro-2-methyl-phenyl)-N-(2,2-dimethylpropyl)-nicotinamide or a pharmaceutically acceptable salt.
  • the present invention further provides a combination product comprising 6-(5-cyclopropylcarbamoyl-3-fluoro-2-methyl-phenyl)-N-(2,2-dimethylpropyl)- nicotinamide or a pharmaceutically acceptable salt thereof and one or more other therapeutic agents which are suitable for the treatment of a glomerular disease.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
EP14735983.0A 2013-07-10 2014-07-08 Losmapimod for use in treating glomerular disease Withdrawn EP3019168A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361844491P 2013-07-10 2013-07-10
PCT/EP2014/064508 WO2015004089A1 (en) 2013-07-10 2014-07-08 Losmapimod for use in treating glomerular disease

Publications (1)

Publication Number Publication Date
EP3019168A1 true EP3019168A1 (en) 2016-05-18

Family

ID=51134104

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14735983.0A Withdrawn EP3019168A1 (en) 2013-07-10 2014-07-08 Losmapimod for use in treating glomerular disease

Country Status (9)

Country Link
US (1) US9707219B2 (enrdf_load_stackoverflow)
EP (1) EP3019168A1 (enrdf_load_stackoverflow)
JP (1) JP2016523943A (enrdf_load_stackoverflow)
KR (1) KR20160030206A (enrdf_load_stackoverflow)
CN (1) CN105358148A (enrdf_load_stackoverflow)
AU (1) AU2014289296A1 (enrdf_load_stackoverflow)
CA (1) CA2917277A1 (enrdf_load_stackoverflow)
RU (1) RU2015156417A (enrdf_load_stackoverflow)
WO (1) WO2015004089A1 (enrdf_load_stackoverflow)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202003035SA (en) * 2017-10-05 2020-04-29 Fulcrum Therapeutics Inc Use of p38 inhibitors to reduce expression of dux4
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
US20200085810A1 (en) * 2018-07-26 2020-03-19 Hoffmann-La Roche Inc. Compounds for use in treating kidney disorders
GB201821138D0 (en) * 2018-12-21 2019-02-06 Benevolentai Bio Ltd Compositions and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003207298B2 (en) * 2002-02-12 2009-09-03 Glaxosmithkline Llc Nicotinamide derivates useful as p38 inhibitors
JPWO2006046528A1 (ja) * 2004-10-29 2008-05-22 興和株式会社 糸球体疾患治療剤
GB0612026D0 (en) * 2006-06-16 2006-07-26 Smithkline Beecham Corp New use
WO2014014706A1 (en) 2012-07-17 2014-01-23 Glaxosmithkline Llc Nicotinamide derivate in the treatment of acute coronary syndrome

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GIPSON DEBBIE S. ET AL: "Assessing the Impact of Losmapimod on Proteinuria in Idiopathic Focal Segmental Glomerulosclerosis", KIDNEY INTERNATIONAL REPORTS, vol. 5, no. 8, 1 August 2020 (2020-08-01), US, pages 1228 - 1239, XP055873205, ISSN: 2468-0249, DOI: 10.1016/j.ekir.2020.05.024 *
R. N. WILLETTE ET AL: "Differential Effects of p38 Mitogen-Activated Protein Kinase and Cyclooxygenase 2 Inhibitors in a Model of Cardiovascular Disease", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 330, no. 3, 1 September 2009 (2009-09-01), pages 964 - 970, XP055075774, ISSN: 0022-3565, DOI: 10.1124/jpet.109.154443 *
See also references of WO2015004089A1 *

Also Published As

Publication number Publication date
JP2016523943A (ja) 2016-08-12
CN105358148A (zh) 2016-02-24
RU2015156417A (ru) 2017-08-15
KR20160030206A (ko) 2016-03-16
US20160220550A1 (en) 2016-08-04
CA2917277A1 (en) 2015-01-15
WO2015004089A1 (en) 2015-01-15
US9707219B2 (en) 2017-07-18
AU2014289296A1 (en) 2016-02-04

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