EP3015538A1 - Désinfectant et/ou article de nettoyage, son utilisation et procédé pour désinfecter et/ou nettoyer des surfaces, des outils et/ou des instruments - Google Patents

Désinfectant et/ou article de nettoyage, son utilisation et procédé pour désinfecter et/ou nettoyer des surfaces, des outils et/ou des instruments Download PDF

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Publication number
EP3015538A1
EP3015538A1 EP14191565.2A EP14191565A EP3015538A1 EP 3015538 A1 EP3015538 A1 EP 3015538A1 EP 14191565 A EP14191565 A EP 14191565A EP 3015538 A1 EP3015538 A1 EP 3015538A1
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EP
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Prior art keywords
disinfection
ppm
wipes
composition
wet
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EP14191565.2A
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German (de)
English (en)
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EP3015538B1 (fr
Inventor
Jesper Heeno Andersen
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Wet Wipe AS
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Wet Wipe AS
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Priority to DK14191565.2T priority patent/DK3015538T3/da
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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/04—Detergent materials or soaps characterised by their shape or physical properties combined with or containing other objects
    • C11D17/049—Cleaning or scouring pads; Wipes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/38—Cationic compounds
    • C11D1/40—Monoamines or polyamines; Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/662—Carbohydrates or derivatives
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/72—Ethers of polyoxyalkylene glycols
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/75—Amino oxides
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/825—Mixtures of compounds all of which are non-ionic
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/835—Mixtures of non-ionic with cationic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/26—Organic compounds containing nitrogen
    • C11D3/33—Amino carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/43—Solvents
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
    • C11D2111/10—Objects to be cleaned
    • C11D2111/14—Hard surfaces
    • C11D2111/20—Industrial or commercial equipment, e.g. reactors, tubes or engines
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2068—Ethers

Definitions

  • the present invention relates to a disinfectant and/or cleaning article comprising a nonwoven cloth which is impregnated with a disinfectant composition and a method for preparing the disinfectant and/or cleaning article.
  • the present invention relates to a method for disinfecting and/or cleaning surfaces, tools and/or instruments.
  • the present invention relates to the use of the disinfectant and/or cleaning article.
  • Single use wipes such as nonwoven cloths impregnated with a cleaning or disinfection solution are widely used in the health care sector and food processing industry for cleaning or disinfecting of areas, which come into contact with skin, food and/or food ingredients.
  • the cloths used in wipes are usually nonwoven and made of a mixture of cellulose and viscose and/or polyester (polyethylene terephthalate, PET) fibres.
  • Alcohol-based disinfectants are inactivated by blood, body fluids, secretions.
  • wipes containing alcohol(s) or alcohol based disinfectants a thorough disinfection of surfaces contaminated by blood, body fluids, secretions is typically performed in a time consuming and demanding two-step process where the contaminated surface is first washed with detergent and water or cleaned with pre-moistened nonwoven or fibre cloths containing water and detergents. The washing step is then followed by disinfection with the alcoholic solution, e.g. with spray or wipes containing alcohol-based disinfectant.
  • the final disinfection must be carried out when the cleaned surface is completely dry which can take up-to 15 minutes, and thus requires excessive waiting time for the cleaning personnel or requires that the cleaning personnel reverts and performs the second disinfecting step before leaving the area.
  • the cleaning personnel must actively dry the surfaces with paper towels between the washing step and the alcohol disinfection step. Disinfection with alcohol based disinfectants before cleaned surfaces are effectively dried up can result in dilution inactivation of the alcohol.
  • wipes used for cleaning in general, in particular in cleaning within the food industry or in medical surgery or examination facilities, e.g. in hospitals, are called wipes.
  • wipes are impregnated with a solution containing a disinfecting agent, e.g. based on disinfectants.
  • a disinfecting agent e.g. based on disinfectants.
  • PHMB poly hexa methylene biguanide
  • ADBAC alkyl dimethyl benzyl ammonium chloride
  • Disinfection liquids were obtained by pressing the wipe liquor out of disinfection wipes impregnated with a disinfectant composition (batch jha-119) comprising 0.18 % PHMB and 0.25 % ADBAC.
  • the concentration of PHMB was determined to 0.13 % in a wipe liquor obtained from a disinfection wipe with 70% viscose fibre and 0.18 % in a wipe liquor obtained from a disinfection wipe with 10% viscose fibre (See Table 9 below).
  • bactericidal activity providing at least 10 4 reduction in number of viable bacterial cells on surfaces according to EN 13697 a metal disc smeared with a bacterial film (comprising viable bacterial cells belonging to Pseudomonas aeruginosa, Escherichia coli, Enterococcus hirae and/or Staphylococcus aureus ) where no mechanical effect is applied to the surface after application; a disinfectant composition identical to batch jha-119 (batch jha-183) shows an initial slow reduction (hereafter called lag phase) and a sudden unexpected accelerated kill rate after 5 minutes incubation (See Table 10).
  • a disinfectant composition (batch jha-185) comprising 0.3 % PHMB, but otherwise identical to batch jha-183, showed a limited improved log reduction after 5 minutes incubation according to EN13697:2001 E (see Table 10). Possibly because the polymeric active substance PHMB exhibits a poor ability to penetrate a bacterial film smeared on the test disc used in EN13697:2001 E.
  • the lag phase discussed above is measurable for disinfectants containing surface active biocides.
  • the active phase where the kill rate is increased, which follows the lag phase, can very shortly for some disinfectants if the composition is not properly formulated.
  • the shorter the active phase the higher is the required active substance concentration to pass the log 4 requirement of EN 13697 in 5 minutes.
  • the kill rate in the active phase follows linear disinfection kinetics according to Chick-Watsons law.
  • Disinfection formulations comprising PHMB did in an unpublished work by Otto Haarder at Wet Wipe A/S and Jesper Heeno Andersen at Brenntag Nordic A/S during the SIB research programme (www.sibêt.dk) show to have log reduction rates of up to 7 log within 1 minute's incubation in suspension test EN 1276 whereas disinfectants based on ADBAC ⁇ 0.2 % has no measureable log reduction within 1 minute's of incubation according to EN 1276 (See Table 2), supporting the finding that the poor disinfection efficacy of PHMB according to EN13697:2001 E is a slow suspension of bacteria in the bacterial film on the test disc in EN13697:2001 E.
  • Biguanides are cationic disinfectants and as other cationic active substances, such as quaternary ammonium compounds (e.g. benzalkonium chloride, didecyl ammonium chloride) they tend to form polar bonds to negatively charged acid groups and polar surface groups on cellulose and viscose contained in the non-woven textiles.
  • quaternary ammonium compounds e.g. benzalkonium chloride, didecyl ammonium chloride
  • a higher concentration of the disinfectants is used in the solutions impregnated to the cloths.
  • this adhesion of cationic disinfectants to the fibres of the cloth is enhanced even more.
  • sodium acetate, sodium-EDTA and similar sodium ion donors can be added to a disinfection formulation to compete with the binding of cationic biocides to negatively charged acid groups and polar surface groups.
  • Adding amphoteric surfactants (zwitter ions) such as: disodium cocoamphodipropionate (CAS 68604-72-8), sodium cocopropylenediamine propionate (CAS 97659-50-2), cocoamidopropyl betaine (CAS 61789-40-0) is another mean of minimizing the binding of cationic biocides to negatively charged acid groups and polar surface groups.
  • amphoteric surfactants added to a disinfection formulation is enhanced foam and formation of macromolecular complexes between biocides, surfactants and other co-formulations, which may result in unpredictable formulation results such as precipitation or neutralisation of the active biocide molecules.
  • the minimum required disinfection efficacy defined is at least a 4 log reduction of the number of bacteria within a period of maximum 5 minutes.
  • a log (logarithmic) reduction means that the number of microorganisms is reduced to 1/10 th of the initial number.
  • a log 4 reduction means that the number of microorganisms is reduced to 1/10 4 of the initial number within 5 minutes.
  • EP 343605 B describes the use of N,N, bis (3 amino propyl) laurylamine as an active ingredient in an aqueous disinfectant especially for disinfecting medical instruments.
  • N,N, bis (3 amino propyl) laurylamine is used as an active ingredient in an aqueous disinfectant, especially for disinfecting medical instruments.
  • an aqueous solution of of N,N, bis (3 amino propyl) laurylamine is applied to surfaces as a layer of foam by spraying the solution on the surface and subsequently rinsing the surface with water or wiping off using a cloth.
  • These disinfecting compositions are applied to instruments by soaking the instruments in the solution or by applying the solution or the surface to be treated in amounts where the surface is visibly wetted and thus requires subsequent rinsing with water and/or wiping with a cloth in order to obtain a clean and disinfected surface.
  • a disinfection and/or cleaning article in the following also called a wipe, comprising a cloth of a nonwoven textile material containing at least 30% by weight of viscose, rayon and/or cellulose fibers, said nonwoven material being impregnated with a aqueous disinfectant composition comprising one or more non-ionic or amphoteric disinfecting agents (in the following also called biocide); 100-1,500 ppm of one or more surfactants as suspension and wetting agents; 100 ppm to ,500 ppm of a solvent; 100 ppm to 1,000 ppm of a complexing agent, which are solubilized or suspended in water, and where the sum of the components do not exceed 6,000 ppm in the resulting disinfectant aqueous composition.
  • a aqueous disinfectant composition comprising one or more non-ionic or amphoteric disinfecting agents (in the following also called biocide); 100-1,500 ppm of one or more surfactants as suspension and wetting agents; 100 ppm to
  • the non-ionic biocide(s), the surfactant(s), the solvent(s) and the complexing agent(s) are all dissolved or suspended in a water base, thus forming a disinfectant composition.
  • This disinfectant composition is then impregnated on the nonwoven material to form the disinfectant and/or cleaning articles or wipes.
  • the impregnated wipes are folded and packed in a liquid tight packaging unit comprising a re-closable opening for extracting one cloth at the time. Each package usually contains 10-100 of the impregnated cloths, e.g. 10, 25, 50, or 100 wipes.
  • the above mentioned lag phase mentioned for the disinfection formulations comprised of PHMB can be overcome by mixing the nonionic or amphoteric active biocide, which also demonstrates surface active properties, with an effective water based composition comprising surfactants, complexing agent(s)and a solvent.
  • the disinfectant wipes according to the present invention do not suffer from the drawbacks of the prior art wipes, i.e. reduced release of disinfectant due to bonding of cationic disinfectants to the polar and acidic groups on cellulose, rayon and/or viscose in the nonwoven cloth, containing disinfectants, because there is no interaction between the polar and acidic groups of the nonwoven cloth material of the wipes and the nonionic disinfectants and surfactants present in the disinfectant composition.
  • the wipes according to the present invention showed excellent efficacy under high organic load resulting in a high log reduction measured for bacteria in the bacterial film in the surface test (similar to example 5 below).
  • the lag phase is insignificant or does not influence the efficacy of the disinfectant composition under the test conditions.
  • the mechanical non-biocidal action which occurs when the disinfectant composition is applied by wiping the wipes impregnated with the disinfectant composition across the surface also plays a role when reducing the lag phase, as the mechanical action also decreases the lag phase, because the bio film is rubbed with the wipes when compared to spraying the disinfectant on the surface or by immersing or dipping instruments into the disinfectant composition.
  • the drying time of a disinfection composition evenly spread on a test surface is shorter than the drying time of a disinfection liquid not evenly spread, and which thus forms streaks or droplets on the surface).
  • the applicant has therefore developed a method to define the optimal impregnation target ratio of a cloth that will assure the minimal required dose of the disinfectant to obtain a optimally wetted surface represented by the test surface of the PUR coated PVC flooring.
  • a wipe When a wipe is taken out of the packet it may e.g. contain liquid in a ratio of 250-300% The wipes wetting ratio then gradually decrease as the liquid is transferred to the surfaces during use and the wipes feels dry and are thrown away at around a liquid ratio of 140-160 %.
  • the wetting power of a wipes according to the invention i.e. impregnated with different ratios of the disinfection composition, do not show a breakpoint at any wetting ratio of the wipes.
  • the wipes according to the present invention are able to provide a fully wetted surface even at low wetting ratios of around 150% or even lower, where the user consider that the wipes feel dry.
  • the wipes according to the present invention comprise a composition comprising N, N bis (aminopropyl) lauryl amine as the non-ionic disinfectant in combination with the surfactants mentioned above, and in particular with lauryldimethylamine oxide as the surfactant.
  • the resulting wipe showed a superb wetting of a test plate of PUR coated PVC flooring. Streaks only occurred below an impregnation ratio of 110% (See Table 6). The disinfection liquid flowed easily out of wipes
  • the wipes are impregnated with different levels of the disinfectant composition above 130% by weight, which is considered the minimum impregnation level at which the wipes can release and spread approximately the same amount of liquid disinfectant composition in an even layer on a test plate surface by wiping.
  • This is a significant discovery, because it is not possible to produce a pack of disinfection wipes with uniform liquid distribution throughout pack of e.g. 10 to 100 wipes due to the gravity force driving the liquid from top to bottom of the stack of wipes.
  • the liquid distribution through a stack of wipes follows a first order equation and reaches an equilibrium determined by the liquid dose, the individual cloth characteristic and the number of wipe in a stack.
  • the wipes according to the present invention are also able to apply the aqueous disinfectant composition impregnated on the wipes to the surface to be treated in an even layer on the surface to be treated in a way which ensure that the entire surface is wetted by a continuous liquid film.
  • the film layer is typically applied in an amount exceeding 9.5 g/m2 surface. Such a surface is defined as a soaking wet surface.
  • the ability of a (disinfectant) composition to cover the entire surface as a continuous film depend on the surface tension of the surface to be treated, the surface tension and wetting power of the (disinfectant) composition and the amount of (disinfectant) liquid applied. If the amount of (disinfectant) liquid is minimized the liquid film reaches a critical thickness where the film becomes instable and breaks into hills and thin valleys.
  • the present invention can provide a continuous film layer on the surface with significantly less liquid per surface area.
  • the wipes according to the invention are able to provide a fully wetted surface where the liquid film layer is significantly thinner as in conventional cleaning techniques, because the film layer is typically applied in an amount of less than 5g/m 2 , typically in an amount of 1.5-3 g/m 2 , in particular 2-3 g/m 2 surface.
  • the wipes according to the present invention reduce the amount of disinfectant composition necessary to cover the entire surface with an even layer of the disinfectant composition, and thus provide a homogenous amount of the disinfecting agent to the treated surface.
  • the wipes according to the present invention also reduces the time needed for effectively disinfecting the surface or instruments.
  • the wipes according to the present invention are suitable for use in:
  • the wipes according to the present invention has thus three different functions normally served by different products:
  • Alcohol-based disinfectants are inactivated by blood, body fluids, secretions, and a thorough disinfection of contaminated surfaces is therefore typically performed in a demanding two-step process where the contaminated surface is initially washed with detergent and water, or cleaned with pre-moistened cleaning cloths, e.g. wipes impregnated with a soap based detergent composition. Then disinfection with an alcohol-based disinfectant is performed. The final disinfection is carried out when the cleaned surface is completely dry which can take up-to 15 minutes when air drying. Alternatively, the surface can be wiped with a dry cloth.
  • Surgical invasive devices such as fibre-endoscopes, are typically cleaned by soaking in enzyme-based cleaning products or cleaning products with a high alkaline pH, before the equipment is disinfected either by immersing into a disinfectant composition or washing machine.
  • the nonwoven textile material of the wipes contain at least 30% by weight of viscose, rayon and/or cellulose fibers in combination with other fibers, such as polyester (polyethyelene terephthalate, PET).
  • the cellulose fibers, and viscose and rayon, which both are modified cellulose fibers contain polar groups and acidic groups.
  • the nonwoven material contains 50-85 % by weight of viscose, rayon and/or cellulose fibers and 15-50 % by weight of polyester fibers, preferably 60-80 % by weight of viscose, rayon and/or cellulose fibers and 20-40 % by weight of polyester fibers, because the increased amount of viscose, rayon and/or cellulose fibers result in that the wipes can contain more of the aqueous disinfectant composition, without leaking of the disinfectant solution into the package. This is due to the increased number of fibers with polar groups, i.e. the viscose, rayon and/or cellulose fibers, which create polar bonds to the water molecules in the aqueous disinfectant composition, and thus increases the wipes overall ability to adsorb the aqueous composition.
  • polar groups i.e. the viscose, rayon and/or cellulose fibers
  • the nonwoven textile cloth of the wipes has a thickness of 35-100 g/m 2 , preferably 50-80 g/m 2 , because they can contain the necessary amount of liquids for obtaining effective disinfection of a certain area with a cloth of a certain size while also being easy to extract from the packages.
  • Thicker wipes i.e. more than 100 g/m 2 , tend to be more difficult to extract from the packages.
  • a wipe having a thickness of 50-80 g/m 2 and a size of e.g. 20*30 cm will be able to disinfect an area of 1-2 m 2
  • an identical larger of wipe e.g. 45-45cm*20 cm, will be able to disinfect an area of typically 2-4 m 2 .
  • the nonwoven textile cloths used in the wipes are preferably structured, i.e. the cloths contain small perforations across the entire surface (see fig. 2 ), because this increases the overall surface of the wipes and thus increases the surface area of the wipes.
  • the wipes release a certain amount of liquid to the surfaces, and some of the liquid is re-adsorbed into the wipes.
  • This ability is further enhanced in structured wipes.
  • dirty surfaces e.g. surfaces contaminated with dirt, cells, e.g. vegetative bacteria, virus, blood cells, tissue cells from humans or animals
  • the increased surface area of the structured wipes may cause that some dirt, cells etc. are also absorbed into the wipes with the re-adsorbed liquid and subjected to the action of the disinfecting agent and thus killed (in case of vegetative cells).
  • the disinfectant composition is an aqueous composition, i.e. a composition based on water, and comprises a nonionic biocide and a water based suspension agent, in which the biocide is dissolved.
  • the non-ionic biocide(s), the surfactant(s), the solvent(s) and the complexing agent(s) are all dissolved or suspended in a water base thus forming a disinfectant composition.
  • pH of the disinfectant composition is adjusted to 9.0 -10.5 prior to impregnation onto the nonwoven cloths using one or more monoprotic acids, such as organic acids, in particular weak organic acids with e.g. lactic acid, acetic acid, formic acid and /or propanoic acid. If necessary alkali, e.g. NaOH, KOH may also be added. After impregnation of the nonwoven cloth this results in a disinfectant composition having a pH value of about 8.0 - 9.5 when the disinfectant composition is twisted out of the wipe; the exact pH value depends on the amount of cellulose, viscose and/or rayon in the nonwoven cloth forming the wipes.
  • monoprotic acids such as organic acids, in particular weak organic acids with e.g. lactic acid, acetic acid, formic acid and /or propanoic acid.
  • alkali e.g. NaOH, KOH may also be added.
  • Monoprotic organic acids such as lactic acid, acetic acid, formic acid and /or propanoic acid are preferred because they are stable at the above mentioned pH range of about 8-10.5, which is necessary for producing the wipes containing viscose, rayon and/or cellulose fibers and because they do not form macromolecular interactions with the other chelating ingredients in the disinfectant composition..
  • the non-ionic or amphoteric disinfecting agent is selected from the group consisting of N,N bis (aminopropyl) laurylamine (CAS :2372-82-9), C10-C16-alkyldimethyl amine N-oxides (CAS: 70592-80-2), such as lauryl dimethyl amine oxide, reaction products of N-C10-C16-alkyltrimethylenediamines with chloroacetic acid (CAS: 139734-65-9) and/or combinations thereof.
  • the disinfecting agent(s) are present in the disinfectant composition in an amount so that the sum of suspended/dissolved solids does not exceed 6,000 ppm.
  • the concentration of the non-ionic or amphoteric disinfecting agent(s) is less than 3,900 ppm.
  • N,N bis (aminopropyl) laurylamine is the preferred non-ionic disinfecting agent, because it does not form bonds with the polar groups or acidic groups in the cellulose, viscose, and/or rayon fibers, and thus does not adhere to the nonwoven cloth and is easily released from the wipes together with the disinfectant composition.
  • N,N bis (aminopropyl) laurylamine is preferred, because it maintains its biocidal effect in applications which include very dirty or blood contaminated surfaces, and because N,N bis (aminopropyl) laurylamine contributes to decreasing the surface tension on the treated surface. In addition, it is stable at the above mentioned pH range of about 8-10.5, which is necessary for producing the wipes containing more than 30% by weight of viscose, rayon and/or cellulose.
  • N,N bis (aminopropyl) laurylamine is marketed in Europe by by Lonza Cologne GmbH, under the brand name Lonzabac 12 or by AkzoNobel Surface Chemistry AB under the brand name triameen Y12D.
  • the disinfecting composition comprises 100-1,000 ppm, preferably 250-1,000 ppm and in particular 400-600 ppm of one or more surfactants.
  • the one or more surfactant(s) is e.g. an amine oxide, preferably a tertiary amine oxide, in particular lauryl dimethylamine oxide or lauramine oxide (CAS:643-20-5 ) , Cocamidopropylamine Oxid (CAS: 68-155-09-9) and/or decyl Dimethylamine oxide (CAS: 2605-79-0), an alkyl glucoside such as a C8 Alkylglukoside (CAS: 7732-18-5), an alcohol ethoxylate, such as C9-C11 ethoxylated alcohols (CAS: 68439-46-3), 2-Ethylhexanol ethoxylate (CAS: 26468-86-0), C12-C14 ethoxylated /propoxylated alcohols (CAS: 68439-51-0 )
  • Lauryl dimethylamine oxide is the preferred surfactant, because the combination of this surfactant and the disinfectant N,N bis (aminopropyl) laurylamin has an acceptable level of foaming for a disinfection composition in wipes, and in particular the level of foaming is acceptable for cleaning of instruments with cavities that is incompatible with foam and because it is anionic and does not form macromolecular complexes at the above mentioned pH range of about 8-10.5.
  • the combination of lauryl dimethylamine oxide and the disinfectant N,N bis (aminopropyl) laurylamin appears to have a synergistic effect in that the overall wetting of the surface is significantly improved, in particular on surfaces which are normally considered difficult in relation to obtaining a fully wet, e.g. on surfaces similar to the test surface used in the examples made of PUR coated PVS flooring material, and because this particular combination is able to provide fully wetted surfaces even at low wetting ratios of the wipes of around 150% content of liquid in the wipes, where the user would otherwise consider that the wipes feel dry.
  • the wipes according to the present invention will be economical in use and will be useable to provide a wetted surface even at low contents of disinfecting composition in the impregnated wipes.
  • the disinfectant composition further comprises 100-1,500 ppm, preferably 250-1,000 ppm and in particular 400-600 ppm of a solvent in order to be able to dissolve (suspend) the bacterial film.
  • the solvent is a water soluble glycol ether, which is preferably selected from the group consisting of ethyl diglycol (CAS:111-90-0), butyl diglycol (CAS:112-34-5), ethylglycol (CAS: 110-80-5), methyl diglycol (CAS:111-77-3), butyl glycol (CAS:111-76-2) and/or combinations thereof.
  • Water soluble glycol ethers are preferred over alcohols and other volatile solvents, because they do not increase the rate of evaporation of the aqueous disinfectant composition from the surface, as is the case when aliphatic alcohols, e.g. as ethanol, propanol, isopropanol or butanol is used as solvent/wetting agent. This results in that the surface is wet for a longer period, which is believed to have a positive effect on the disinfection of the surfaces treated with the wipes according to the invention.
  • aliphatic alcohols e.g. as ethanol, propanol, isopropanol or butanol
  • Ethyl diglycol is the preferred, because it facilitates spreading of the composition on the surface.
  • ethyl diglycol has a higher boiling point than ethyl glycol and methyl diglycol and thus results in an even lower rate of evaporation of the aqueous disinfectant composition.
  • the disinfectant composition further comprises 100-1,000 ppm, preferably 250-900 ppm, in particular 400-600 ppm, of a complexing agent which is selected form EDTA (ethylene diamine tetra acetic acid ; CAS 60-00-4), GLDA (L-glutamic acid N,N-diacetic acid, tetra sodium salt; CAS: 51981-21-6), MGDA (Methyl glycine diacetic acid; CAS: 164462-16-2), N,N-bis(carboxymethyl)- alanine, trisodium salt (CAS: 5064-31-3) and/or combinations thereof.
  • EDTA ethylene diamine tetra acetic acid ; CAS 60-00-4
  • GLDA L-glutamic acid N,N-diacetic acid, tetra sodium salt
  • MGDA Metal glycine diacetic acid
  • N,N-bis(carboxymethyl)- alanine, trisodium salt CAS
  • the weight ratio of nonwoven cloth: aqueous disinfection composition of the wipes according to the present invention is between 1:1.3 and 1: 5 (corresponding to 130-500% by weight aqueous disinfectant composition in relation to the weight of the nonwoven cloth), because this results in damp wipes, which can deliver the required amount of disinfectant composition for obtaining the efficient surface wetting required for disinfection, i.e. a kill rate reduction of at least 10 4 , or log 4, when wiping the wipes across the surface or instrument without applying any significant extra pressure compared to the pressure in relation to the pressure which is naturally applied by a person during wiping of the surface or instruments.
  • the cloth is preferably impregnated the aqueous disinfecting composition in a weight ratio of with 1:2 to 1: 4.0 (or 200-400 % by weight), or more preferred 1:2.2 to 3.5 (or 220-350% by weight).
  • a wet wipe is defined as a wipe, from which the liquid is dripping without wringing the wipe.
  • a wipe is damp, when a person considers that the wipe feels wet when holding it, but the wipe is able to retain all liquids and does not drip.
  • a method for disinfecting surfaces and/or instruments comprises wiping the surface thereof with a disinfection article as described above and obtaining a continuous liquid film on the surface or instrument. After applying the film the treated surface is left to dry by air drying. Tools or instruments may then be subjected to subsequent thorough sterilisation or dishwashing either immediately after disinfection or later.
  • the surface and/or instruments are preferably initially cleaned by wiping the surface thereof with a disinfection and/or cleaning article according to the present invention. This can be done easily as the wipes are folded. The outer surface of the cloth is used for cleaning and subsequently the wipe is refolded so that the other side of the cloth, which continues to be clean and now faces outwards, is used for disinfection.
  • the present invention also relates to the use of a disinfection and/or cleaning article according to the present invention for cleaning and/or disinfecting surfaces and/or instruments used in hospitals and/or medical care or when nursing patients.
  • the present invention also relates to the use a disinfection and/or cleaning article according to the present invention for cleaning and/or disinfecting surfaces tools, and/or instruments used in food industry.
  • All reagents used in the examples are of analytical grade and/or appropriate for microbiologial purpose. Water is sterilized.
  • a standard surfactant composition of 0.15 % or 1.5 g/liter sodium monoalkyl benzene sulfonate (SMBS) (CAS: 85117-50-6 ) manufactured by Huntsman Surface Sciences UK Limited in tap water is prepared.
  • the standard surfactant composition is impregnated on nonwoven-structured cloths, 70 g/m 2 , made of a fiber composition of 70% by weight viscose and 30% by weight PET with 70% manufactured by Norafin Industries (Germany) GmbH in amounts according to table 1.
  • a suspension agent is prepared by mixing Alanine, N,N-bis(carboxymethyl)-, trisodium salt (Trilon M liquid; CAS:5064-31-3), lactic acid (CAS: 50-21-5), ethyl diglycol (EDG 99%; CAS: 111-90-0) and Lauryldimethylamine oxide (ammonyx LO; CAS: 68955-55-5) and Lonzabac® 12.30 from Lonza GmbH is added in the amounts shown below in a bottle and adding water to a total of 1000 g. This solution is stirred/shaken until a homogenous mixture is obtained.
  • Table 3 Composition of batch jha-66 Raw material Chemical name Cas no.
  • the resulting composition (called JHA-66 in the following) is impregnated on nonwoven-structured cloths, 70 g/m 2 , made of a fiber composition of 70% by weight viscose and 30% by weight PET with 70% provided by manufactured by Norafin Industries (Germany) GmbH in amounts according to table 3.
  • the wipes prepared according to examples 1-3 were each folded as shown in fig. 1-2 , either prior to or after impregnation, and a 0.25 m 2 test plate of PVC coated with PUR and having an uneven surface (corresponding to the test plate used in prEN 16615, a standard which is yet to be finally approved) (supplied by Verbund fur Angewandte Hygiene e.V.) was wiped from one side to the other in parallel tracks, thus covering the entire surface, see fig. 4 , and the wipe was weighed immediately after wiping. The amount of liquid applied to the surface is inspected and evaluated visually whether the surface is covered with a continuous film over the entire surface or whether droplets and/or stripes of liquid are formed on the surface.
  • amount of liquid applied to the surface is calculated from the weight of the wipe before and after wiping, and the amount of liquid per m 2 is calculated and plotted in a graphic view shown in fig. 3A-D , where the X-axis shows the weight % of liquid in relation to the nonwoven cloth and the Y-axis shows the amount of liquid applied to the surface in g/m 2 .
  • SMBS 3,5 g/litre SMBS was needed in example 2 to obtain a fully wetted surface.
  • This concentration of SMBS was assayed to an impregnation ratio of at least 100% by weight liquid to weight of nonwoven material(See Table 5) and the liquid release plotted against the impregnation ratio ( Fig. 2D ).
  • the curve showed a break point at 260% impregnation. Below the break point, the release of liquid significantly reduced and resulted in a marked increase in friction between surface and wipes. A poor wetting of the PUR coated PVC flooring with streaks and dry spots followed.
  • the test shows that although a low surface tension of a disinfection liquid is a necessity, a low surface tension is not enough for obtaining a wet surface by wiping the PUR coated PVC flooring.
  • composition of PHMB having the following composition was prepared.
  • Table 8 composition of batch jha-119 Chemical name Cas no. Concentration in pre-mix 40 x dilution Citric acid 6.6 % 1650 ppm 0.17 % Triethanolamin 99/90 2-[bis[2-hydroxyethyl)amino]ethanol 102-71-6 3.0 % 750 ppm 0,08% Ethyldiglycol 2-(2-ethoxy)ethanol 111-90-0 2.5 % 625 ppm 0,06 % Dissolvine GL 38 Tetrasodium N,N-bis(carboxymethyl)-L-glutaminate 51981-21-6 6.3 % 1575 ppm 0,16 % BTC 50 Alkyldimethylbenzyl ammoniumchloride 68424-85-1 10.3 % 2575 ppm 0,26 % Ammonyx LO Lauramine Oxide 68955-55-5 0.74 % 185 ppm 0,02 % Berol OX 91/6 Alcohol eth
  • a nonwoven cloth (cloth 1) containing 70% viscose and 30% by weight of polyester (PET) having a structured surface as described above (of unknown origin) was impregnated with 360 % by weight of jha-119 in relation to the weight of the cloth and a second type of nonwoven cloth (cloth 2) containing 10% by weight of viscose and 90% polyester (of unknown origin) was impregnated with 325% by weight of jha-119 in relation to the weight of the cloth.
  • PET polyester
  • the two impregnated cloths were tested for bactericidal effect on Pseudomonas Aeruginosa ATCC 15442 at 3 different contact time intervals as indicated in table below.
  • the test was conducted at room temperature (20-22 °C).
  • diluent is tryptone solution; 1.0 g tryptone (pancreatic diges of casein)+ 8.5 g NaCl in 1.0 1 of water
  • a solution of 0.3 g/l of bovine serum albumin was in the bacterial suspension used as interfering substance, which corresponds to clean conditions.
  • Reference sample steel plates were treated with sterilised tap water in corresponding amounts and time periods.
  • the steel plates were treated with 10 ml of a neutralising agent comprising 10g/l soduim sulphate, 30 g/l polysorbate 80, 3g/l lecithin and 30g/l saponin in a 4-5 cm diameter container containing 5 g of glass beads.
  • a neutralising agent comprising 10g/l soduim sulphate, 30 g/l polysorbate 80, 3g/l lecithin and 30g/l saponin in a 4-5 cm diameter container containing 5 g of glass beads.
  • the steel plates were placed upside down on top of the beads to ensure that the beads have the maximum opportunity to aid cell removal.
  • the plates were placed in a horizontal shaker for 1 min at 150 min -1
  • a series of two-fold dilutions from 10-1 to 10-2 for the bacterial strains is prepared from the neutralised mixture and the diluent. Take a sample of 1.0 ml of the neutralised mixture and each of the dilutions in duplicate and inoculate the pour plates.
  • For the water control after a neutralisation time of 5 min ⁇ 10 s, for the bacterial containing samples dilutions were prepared (10 -3 , 10 -4 , 10 -5 and 10 -6 dilutions) of the neutralised mixture in the tryptone diluent by taking a sample of 1,0 ml of each of the dilutions from the inoculated the pour plates.
  • the stainless steel disc was recovered, the neutralisation medium drained off and was then rinsed with 10 ml of sterilized water and transferred to a Petri dish containing about 10 ml of solidified TSA where it was placed on top of the agar, test side uppermost.
  • 0.1 ml of sterilised water was poured on the stainless steel disc and with a sterile pipette tip or a sterile spatula scraped for any residual desiccated inoculum on the surface of the disc for 1 min.
  • About 10 ml of the same melted counting medium cooled to 45 °C ⁇ 1 °C was poured over the stainless steel test surface.
  • a disinfectant composition similar to batch jha-119 and batch jha-183 was prepared, with the exception that the concentration of PHMB was raised to 3,000 ppm (batch called jha-185) and was thus slightly higher than in example 5.
  • the log reduction of the disinfectant composition was tested in a similar way as in example 5, except that the time periods were 5, 10, and 15 minutes.
  • the mechanical non-biocidal action which occurs when the disinfectant composition is applied by wipes impregnated with the disinfectant composition across the surface, was examined by impregnating a cloth similar to cloth 1 used in examples 1-6 with a surfactant solution containing 0.15 % (or 1.5 g/liter) of sodium monoalkyl benzene sulfonate (SMBS) (CAS no.: 85117-50-6).
  • SMBS sodium monoalkyl benzene sulfonate
  • a plain non structured nonwoven cloth of PET 55% cellulose: 45% PET
  • 70g/m2 was impregnated with the composition.
  • the impregnation ratio of cloths to surfactant solution was 650%, which is just below the absorption capacity of the cloths.
  • Streak plates were prepared and incubated for 24h at 35 ⁇ 2°C. Isolated colonies from the streak plates were subcultured for 24h at 35 ⁇ 2°C and then colonies from the subculture were used to freshly prepare the bacterial working solution which was maintained at 20 ⁇ 1°C in water bath until use.
  • the bacterial inoculum was suspended in general diluent and prepared from a subculture to obtain OD620nm 0.15 -0.46 equalling 1.5 -5 x 10 9 CFU/ml. To confirm the inoculum size, the inoculum was serial diluted and 10 7 and 10 8 dilutions were spread onto TSA plates which were incubated for 24h - 48h at 35 ⁇ 2°C.
  • the interfering substances of bovine albumin and sheep erythrocytes were added into the bacterial suspension that was maintained at 20 ⁇ 1°C in a water bath.50 ⁇ l of the bacterial suspension was then spread onto the test field 1 and on the field for Dry Control.
  • the PVC flooring was cut in one big and one small piece. On the big flooring four different test fields: 1, 2, 3, and 4 were drawn and on the small flooring two test fields for the Dry Control Dc0 and Dct were drawn.
  • the surface was cleaned with 70% iso-propanol and allowed to dry for 2 hours.
  • the wipes were sterilized in the autoclave and then wipes marked cloth 1 were soaked in water.
  • the impregnated cloth 1 showed 3.9 log reduction of bacteria in a bacterial film on a PU coated PVC flooring as recommended in prEN16615 as compared to the standard wipe included in prEN16615 that resulted in a 3.1 log reduction (See Table 11).
  • Table 11 Wipe material Log reduction Cloth 1(70-30) 3.9 PET wipe (0-100) 3.1
  • the non-impregnated wipe from cloth 1 also removed bacteria more efficiently than the pulp:Polyethylenterephthalat (PET) wipe recommended by the standard, FprEN 16615.
  • PET Polyethylenterephthalat
  • Sodium monoalkyl benzene sulfonate is a linear alkyl sulphonate with a critical micelle concentration of 0.65 g/liter and a surface tension of 35 mN/m.
  • the wipes gave a homogenous and easy spreading of the surfactant liquid without dry spots, streaks or droplets on the test plate of the PU coated PVC flooring.
  • a disinfectant formulation according to the invention was tested to give a reduction of 6 log in 5 minutes (see Table 14).
  • test was similar to the procedure given in example 5 except from using different bacteria/fungus strains, different test conditions ("clean” or "dirty") as indicated in table 14 below.
  • the "clean" test conditions were represented by an organic load of an interfering suspension of 0.03 % bovine albumin.
  • the "dirty" test conditions were represented by an organic load of an interfering suspension of 0.3 % bovine albumin + 0.3 % sheep erythrocytes.
  • Table 12 Composition of batch "jha-37" Raw material Batch no. Chemical name Cas no.
  • Raw Recipé Mix Con-tent VAND 100 % 985 g TRILON LIQUID M Alanine, N,N-bis(carboxymethyl)-, trisodium salt 5064-31-3 40% 1,2 g 480 ppm 0,48 g M ⁇ LKESYRE Lactic Acid 50-21-5 70% 0,2 g 140 ppm 0,14 g EDG 99 % Ethyl diglykol 111-90-0 99% 0,75 g 744 ppm 0,99 g AMMONYX LO Lauryldimethylamine oxide 68955-55-5 30% 1,75 g 525 ppm 0,30 g Lonzabac 12.30 DEG42290 36 30% 9,0 g 2700 ppm 2,10 g Total solid matter 997,9 g 4590 ppm Table 13.
  • the neutraliser (TLSH-SDS) used in example 8 comprises 100g/l polysorbate 80; 60g/l saponin; 5g/l lechitin; 1g/l histidine and 5g/l SDS
  • a growth medium of malt extract agar (MSA) pH 5.2 (30.0 g technical grade malt extract; 3.0 g soya peptone; 15.0 g agar and 1000.0 ml water) is used.
  • the wipes comprising the disinfection composition according to the invention represented by batch jha-37 do not suffer from the drawbacks of the prior art wipes, i.e. reduced release of disinfectant due to bonding of cationic disinfectants to the polar and acidic groups on cellulose, rayon and/or viscose in the nonwoven cloth, containing disinfectants, because there is no interaction between the polar and acidic groups of the nonwoven cloth material of the wipes and the nonionic disinfectants and surfactants present in the disinfectant composition.
  • batch jha-35 (see composition in table 13 above in example 8) of the disinfectant composition was tested in a procedure similar to example 5, but under a high organic load (high soiling) represented by an interfering suspension of 1% yeast extract + 1 % bovine albumin, and at a an incubation temperature of 10°C +/- 1 °C and an incubation time of 30 minutes.
  • high organic load high soiling
  • the neutralizer used in example 8 was also used in example 9.
  • Batch jha-35 was tested under test conditions with high load conditions (See Table 15) and showed excellent efficacy under high organic load, because a high log reduction was measured for bacteria in the bacterial film in the surface test similar to example 5. This further shows that the lag phase of the composition according to the present invention is insignificant or does not influence the efficacy of the disinfectant composition under the test conditions. Note that a log reduction of 5 under 5 minutes incubation at 25°C is roughly equivalent to a log reduction of 5 under 30 minutes incubation at 10°C.

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WO2018132692A1 (fr) * 2017-01-12 2018-07-19 Georgia-Pacific Nonwovens LLC Matériau non tissé pour le nettoyage et la désinfection de surfaces
WO2018226559A1 (fr) * 2017-06-05 2018-12-13 Lonza Inc. Composition d'essuyage désinfectante à destruction rapide et lingettes pré-humidifiées préparées à partir de celle-ci
WO2021129930A1 (fr) * 2019-12-23 2021-07-01 Ecolab Usa Inc. Détergent deux en un pour lave-vaisselle
CN113271834A (zh) * 2019-01-21 2021-08-17 大王制纸株式会社 清扫用片和清扫用片的制造方法
EP3856883A4 (fr) * 2018-09-28 2021-11-17 Siemens Healthcare Diagnostics, Inc. Réactif de lavage contenant de l'alcool gras alcoxylé et ses procédés de production et d'utilisation
CN116267927A (zh) * 2023-05-11 2023-06-23 山东新华莎罗雅生物技术有限公司 强化杀菌效果的消毒湿巾及其制备方法
US11718813B2 (en) 2020-03-23 2023-08-08 Ecolab Usa Inc. 2-in-1 sanitizing and rinse aid compositions employing amine based surfactants in machine warewashing

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US6495499B1 (en) * 2001-12-10 2002-12-17 Colgate-Palmolive Company Floor cleaning wipe
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EP0343605B1 (fr) 1988-05-27 1992-12-30 Lonza Ag Agent désinfectant tuberculicide
EP0612470B1 (fr) 1993-02-25 1996-06-05 Schülke & Mayr GmbH & Co. KG Concentré d'agent désinfectant et agent désinfectant à base d'amine et d'alcool et son utilisation
US20050054257A1 (en) * 1999-09-27 2005-03-10 The Procter & Gamble Company Pre-moistened wipe comprising polymeric biguanide for treating a surface
WO2002092750A1 (fr) * 2001-05-08 2002-11-21 Unilever Plc Linge de nettoyage antimicrobien
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Publication number Priority date Publication date Assignee Title
WO2018132692A1 (fr) * 2017-01-12 2018-07-19 Georgia-Pacific Nonwovens LLC Matériau non tissé pour le nettoyage et la désinfection de surfaces
WO2018226559A1 (fr) * 2017-06-05 2018-12-13 Lonza Inc. Composition d'essuyage désinfectante à destruction rapide et lingettes pré-humidifiées préparées à partir de celle-ci
US11432545B2 (en) 2017-06-05 2022-09-06 Arxada, LLC Fast kill disinfectant wiping composition and premoistened wipes made from same
EP3856883A4 (fr) * 2018-09-28 2021-11-17 Siemens Healthcare Diagnostics, Inc. Réactif de lavage contenant de l'alcool gras alcoxylé et ses procédés de production et d'utilisation
JP2022501487A (ja) * 2018-09-28 2022-01-06 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド アルコキシル化された脂肪族アルコールを含む洗浄剤、およびその製造方法と使用方法
CN113271834A (zh) * 2019-01-21 2021-08-17 大王制纸株式会社 清扫用片和清扫用片的制造方法
WO2021129930A1 (fr) * 2019-12-23 2021-07-01 Ecolab Usa Inc. Détergent deux en un pour lave-vaisselle
US11718813B2 (en) 2020-03-23 2023-08-08 Ecolab Usa Inc. 2-in-1 sanitizing and rinse aid compositions employing amine based surfactants in machine warewashing
CN116267927A (zh) * 2023-05-11 2023-06-23 山东新华莎罗雅生物技术有限公司 强化杀菌效果的消毒湿巾及其制备方法
CN116267927B (zh) * 2023-05-11 2023-08-25 山东新华莎罗雅生物技术有限公司 强化杀菌效果的消毒湿巾及其制备方法

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