EP2956449A1 - Method for the synthesis of 4-(heterocycloalkyl)-benzene-1,3-diol compounds - Google Patents

Method for the synthesis of 4-(heterocycloalkyl)-benzene-1,3-diol compounds

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Publication number
EP2956449A1
EP2956449A1 EP14710599.3A EP14710599A EP2956449A1 EP 2956449 A1 EP2956449 A1 EP 2956449A1 EP 14710599 A EP14710599 A EP 14710599A EP 2956449 A1 EP2956449 A1 EP 2956449A1
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Prior art keywords
general formula
group
benzene
polar solvent
diol
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EP14710599.3A
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German (de)
French (fr)
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EP2956449B1 (en
Inventor
Jean-Guy Boiteau
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Galderma Research and Development SNC
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Galderma Research and Development SNC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms

Definitions

  • the present invention relates to a process for the synthesis of 4- (heterocycloalkyl) -benzene-1,3-diol compounds having the following general formulas (I) and (II):
  • X represents an oxygen atom or a sulfur atom.
  • 2,4-dibenzyloxy bromobenzene (2) is then reacted in the presence of butyllithium with heterocycloalkanones of the general formula (3a) or (3b) (FIGS. 1 and 2) to provide the benzyl alcohols, respectively, of the general formula (4a) or (4b).
  • a first disadvantage of this process is the introduction of a sequence of protection / deprotection reactions of phenols with benzyl groups. Indeed, the need to protect the phenol functions of the compound (1) leads, on the one hand, to add two steps in the synthesis of the compounds (I) and (II) and on the other hand, to unnecessarily increase the mass of the intermediates (2), (4a) or (4b), which is not adapted from an industrial point of view, especially in terms of the economy of atoms.
  • a second disadvantage of this synthetic route is the use, at the second stage, of cryogenic conditions (Butyllithium, of the order of -70 ° C.) which require equipment adapted to the industrial scale and which result in a additional cost in this process.
  • cryogenic conditions butyllithium, of the order of -70 ° C.
  • the present invention therefore aims to solve the problems mentioned above by proposing a process for the synthesis of 4- (heterocycloalkyl) -benzene-1,3-diol of general formula (I) or (II), comprising fewer steps, more economical, simpler and adaptable to the industrial scale.
  • the object of the present invention relates to a process for the synthesis of a 4- (heterocycloalkyl) -benzene-1,3-diol corresponding to the general formula (I)
  • X represents an oxygen atom.
  • Another subject of the invention relates to a process for the synthesis of a 4- (heterocycloalkyl) benzene-1,3-di general (II)
  • the polar solvent used in the two above processes is selected from the group comprising alcohols such as methanol for example, carboxylic acids such as acetic acid for example, esters such as ethyl acetate by for example, ethers such as tetrahydrofuran, for example, water and a mixture of these solvents.
  • the alcohols are chosen from methanol, ethanol and isopropanol.
  • the apolar solvent is chosen from the group comprising dichloromethane and 1,2-dichloroethane.
  • the palladium catalyst is selected from the group consisting of palladium on carbon, palladium hydroxide and palladium acetate.
  • the hydrogen pressure used in the processes of the invention is between 1 and 10 bar.
  • X represents an oxygen atom or a sulfur atom is obtained by reacting resorcinol with a heterocycloalkanone corresponding to the general formula (3b) in a polar solvent and in the presence of a base.
  • the base is selected from the group consisting of sodium hydroxide, potassium hydroxide, lithium hydroxide and metal alkoxides, preferably sodium methanolate and potassium tert-butoxide.
  • the base is sodium hydroxide or potassium hydroxide.
  • the polar solvent is selected from the group consisting of water and alcohols, preferably methanol, ethanol, and isopropanol.
  • the polar solvent is water.
  • resorcinol and heterocycloalkanone (3a) or (3b) are used in a resorcinol / heterocycloalkanone molar ratio of between 1 and 8.
  • Another subject of the invention relates to the compound of general formula (7a) or (7b)
  • the compound is selected from the group consisting of 4- (4-hydroxy-tetrahydro-pyran-4-yl) benzene-1,3-diol and 4- (3-hydroxy-tetrahydro-pyran-3- yl) -benzene-1,3-diol.
  • This new synthetic route uses resorcinol (6) as a starting material, which is economically very advantageous compared to the price of 2,4-dihydroxybromobenzene (1).
  • the first step of this new synthetic route is an original step of coupling resorcinol (6) with heterocycloalkanones (3a) or (3b) in the presence of a base.
  • the base used is preferably selected from the group consisting of sodium hydroxide, potassium hydroxide, lithium hydroxide and metal alkoxides. sodium methanolate or potassium tert-butoxide, for example.
  • This step is carried out in a polar solvent, preferably in water or in alcohols, and allows the compounds (7a) or (7b) to be obtained directly, respectively.
  • the alcohols are preferably selected from the group comprising methanol, ethanol and isopropanol.
  • an excess of resorcinol (6) is preferably used to react on the heterocycloalkanone (3a) or (3b). More specifically, the resorcinol / heterocycloalkanone molar ratio is between 1 and 8 and preferably between 2 and 4.
  • the temperature at which this coupling step is performed represents another advantage of this new synthetic route. Indeed, this first step is carried out at ambient temperature, in water or in alcohols, which makes it possible to avoid the cryogenic step (of the order of -70 ° C.) of the process disclosed in WO 2010/063773 .
  • the reaction intermediates (7a) or (7b) are obtained in crystalline form after neutralization of the medium and makes it possible to dispense with the purification steps.
  • a pH equal to 7 or a pH of 7 to 8.
  • the pH is equal to 7.
  • the second step of this new synthesis route is a hydrogenation or reduction step of the intermediates (7a) or (7b) to obtain the compounds of formula (I) or (II), respectively.
  • the hydrogenation of the intermediates (7a) or (7b) is carried out in a polar solvent.
  • Preferred polar solvents are selected from the group consisting of alcohols such as methanol for example, carboxylic acids such as acetic acid for example, esters such as ethyl acetate for example, ethers such as tetrahydrofuran for example, water and a mixture of these solvents.
  • the alcohols are preferably selected from the group comprising methanol, ethanol and isopropanol.
  • the hydrogenation is carried out in the presence of a palladium-based catalyst.
  • the preferred catalysts are selected from the group consisting of palladium on carbon, palladium hydroxide, palladium acetate, or any other reduction catalyst known to those skilled in the art.
  • the hydrogen pressure used is between 1 and 10 bar and preferably between 3 and 7 bar.
  • X represents a sulfur atom
  • the reduction of the intermediates (7a) or (7b) is carried out in an apolar solvent.
  • Preferred apolar solvents are selected from the group consisting of dichloromethane and 1,2-dichloroethane.
  • the reduction is carried out in the presence of a silicon hydride reducing agent and a Lewis acid.
  • the preferred reducing agents are selected from the group consisting of triethylsilane, polymethylhydrosiloxane (PMHS) and any other silicon hydride known to those skilled in the art.
  • the preferred Lewis acids are selected from the group consisting of boron trifluoride and its complexes such as, for example, trifluoroborane etherate.
  • FIG. 3 Process for preparing the compounds of the invention of formula (I)
  • FIG. 4 Process for preparing the compounds of the invention of formula (II) Examples

Abstract

The invention relates to a method for the synthesis of 4-(heterocycloalkyl)-benzene-1,3-diol compounds of general formulae (I) and (III) wherein X can be an oxygen atom or a sulphur atom. The invention also relates to a method for the synthesis of the reactive intermediate of general formula (7a) or 7b), and to said novel compounds as synthesis intermediates.

Description

PROCEDE DE SYNTHESE DE COMPOSES 4-(HETEROCYCLOALKYL)-BENZENE-1 ,3-DIOL  PROCESS FOR THE SYNTHESIS OF 4- (HETEROCYCLOALKYL) -BENZENE-1,3-DIOL COMPOUNDS
La présente invention se rapporte à un procédé de synthèse de composés 4-(hétérocycloalkyl)-benzène-1 ,3-diol répondant aux formules générales (I) et (II) suivantes : The present invention relates to a process for the synthesis of 4- (heterocycloalkyl) -benzene-1,3-diol compounds having the following general formulas (I) and (II):
dans lesquelles X représente un atome d'oxygène ou un atome de soufre. in which X represents an oxygen atom or a sulfur atom.
La synthèse de composés analogues à ceux des formules (I) et (II) ci-dessus a été décrite dans la demande de brevet WO 2010/063773. Cette synthèse est réalisée en trois étapes (figures 1 et 2) The synthesis of compounds analogous to those of formulas (I) and (II) above has been described in the patent application WO 2010/063773. This synthesis is carried out in three stages (Figures 1 and 2)
Dans la première étape du procédé décrit dans la demande de brevet WO 2010/063773 (figures 1 et 2), le 2,4-dihydroxy bromobenzene (1 ) est mis en réaction avec du bromure de benzyle pour fournir le 2,4-dibenzyloxy bromobenzene (2). In the first step of the process described in patent application WO 2010/063773 (FIGS. 1 and 2), 2,4-dihydroxybromobenzene (1) is reacted with benzyl bromide to provide 2,4-dibenzyloxy bromobenzene (2).
(2) (2)
Le 2,4-dibenzyloxy bromobenzene (2) réagit ensuite en présence de butyllithium avec des hétérocycloalkanones de formule générale (3a) ou (3b) (Figures 1 et 2) pour fournir les alcools benzyli ues, respectivement, de formule générale 4a) ou (4b).  2,4-dibenzyloxy bromobenzene (2) is then reacted in the presence of butyllithium with heterocycloalkanones of the general formula (3a) or (3b) (FIGS. 1 and 2) to provide the benzyl alcohols, respectively, of the general formula (4a) or (4b).
(i) (il) ,  (i) (il),
sont finalement obtenus, respectivement à partir des composés de formule générale (4a) et (4b), par hydrogénation dans le méthanol en présence d'hydrogène et d'un catalyseur à base de palladium. are finally obtained, respectively from the compounds of general formula (4a) and (4b), by hydrogenation in methanol in the presence of hydrogen and a palladium-based catalyst.
Un premier inconvénient de ce procédé est l'introduction d'une séquence de réactions de protection / déprotection des phénols par des groupements benzyles. En effet, la nécessité de protéger les fonctions phénols du composé (1 ) conduit, d'une part, à rajouter deux étapes dans la synthèse des composés (I) et (II) et d'autre part, à augmenter inutilement la masse des intermédiaires (2), (4a) ou (4b), ce qui n'est pas adapté d'un point de vue industriel, notamment au niveau de l'économie d'atomes. A first disadvantage of this process is the introduction of a sequence of protection / deprotection reactions of phenols with benzyl groups. Indeed, the need to protect the phenol functions of the compound (1) leads, on the one hand, to add two steps in the synthesis of the compounds (I) and (II) and on the other hand, to unnecessarily increase the mass of the intermediates (2), (4a) or (4b), which is not adapted from an industrial point of view, especially in terms of the economy of atoms.
De plus, cette synthèse fait intervenir du bromure de benzyle dont les propriétés lacrymogènes rendent délicate la manipulation à l'échelle industrielle.  In addition, this synthesis involves benzyl bromide whose lachrymatory properties make it difficult to handle on an industrial scale.
Un deuxième inconvénient de cette voie de synthèse est l'utilisation, à la deuxième étape, de conditions cryogéniques (Butyllithium, de l'ordre de -70°C) qui nécessitent un équipement adapté à l'échelle industrielle et qui ont pour conséquence un coût supplémentaire dans ce procédé.  A second disadvantage of this synthetic route is the use, at the second stage, of cryogenic conditions (Butyllithium, of the order of -70 ° C.) which require equipment adapted to the industrial scale and which result in a additional cost in this process.
Enfin, un troisième inconvénient de ce procédé est le prix élevé du 2,4-dihydroxy bromobenzene ainsi que celui du butyllithium.  Finally, a third disadvantage of this process is the high price of 2,4-dihydroxy bromobenzene as well as that of butyllithium.
Dans le cadre du développement de ces composés, il existe un besoin de disposer d'une méthode permettant de préparer économiquement et dans des conditions de sécurité les composés de formule générale (I) ou (II) tout en évitant les inconvénients mentionnés ci- dessus. In the context of the development of these compounds, there is a need for a method making it possible to economically prepare, under conditions of safety, the compounds of general formula (I) or (II) while avoiding the disadvantages mentioned above. .
La présente invention vise donc à résoudre les problèmes cités ci-dessus en proposant un procédé de synthèse de 4-(hétérocycloalkyl)-benzene-1 ,3-diol de formule générale (I) ou (II), comportant moins d'étapes, plus économique, plus simple et susceptible d'être adapté à l'échelle industrielle. The present invention therefore aims to solve the problems mentioned above by proposing a process for the synthesis of 4- (heterocycloalkyl) -benzene-1,3-diol of general formula (I) or (II), comprising fewer steps, more economical, simpler and adaptable to the industrial scale.
L'objet de la présente invention est relatif à un procédé de synthèse d'un 4- (hétérocycloalkyl)-benzene-l ,3-diol répondant à la formule générale (I) The object of the present invention relates to a process for the synthesis of a 4- (heterocycloalkyl) -benzene-1,3-diol corresponding to the general formula (I)
dans laquelle X représente un atome d'oxygène ou de soufre, caractérisé en ce qu'un composé répondant à la formule générale 7a) in which X represents an oxygen or sulfur atom, characterized in that a compound corresponding to the general formula 7a)
(7a)  (7a)
réagit avec de l'hydrogène en présence d'un catalyseur à base de palladium dans un solvant polaire lorsque X représente un atome d'oxygène ou avec un réducteur de type hydrure de silicium et un acide de Lewis dans un solvant apolaire lorsque X représente un atome de soufre. De préférence, X représente un atome d'oxygène. reacts with hydrogen in the presence of a palladium catalyst in a polar solvent when X represents an oxygen atom or with a silicon hydride reducing agent and a Lewis acid in an apolar solvent when X represents a sulfur atom. Preferably, X represents an oxygen atom.
Un autre objet de l'invention concerne un procédé de synthèse d'un 4- (hétérocycloalkyl)-benzene-l ,3-di générale (II) Another subject of the invention relates to a process for the synthesis of a 4- (heterocycloalkyl) benzene-1,3-di general (II)
dans laquelle X représente un atome d'oxygène ou de soufre, caractérisé en ce qu'un composé répondant à la formule générale 7b) in which X represents an oxygen or sulfur atom, characterized in that a compound corresponding to the general formula 7b)
(7b)  (7b)
réagit avec de l'hydrogène en présence d'un catalyseur à base de palladium dans un solvant polaire lorsque X représente un atome d'oxygène ou avec un réducteur de type hydrure de silicium et un acide de Lewis dans un solvant apolaire lorsque X représente un atome de soufre. reacts with hydrogen in the presence of a palladium catalyst in a polar solvent when X represents an oxygen atom or with a silicon hydride reducing agent and a Lewis acid in an apolar solvent when X represents a sulfur atom.
De préférence, le solvant polaire utilisé dans les deux procédés ci-dessus est choisi dans le groupe comprenant les alcools comme le méthanol par exemple, les acides carboxyliques comme l'acide acétique par exemple, les esters comme l'acétate d'éthyle par exemple, les éthers comme le tetrahydrofuranne par exemple, l'eau et un mélange de ces solvants. Avantageusement, les alcools sont choisis parmi le méthanol, l'éthanol et l'isopropanol. Preferably, the polar solvent used in the two above processes is selected from the group comprising alcohols such as methanol for example, carboxylic acids such as acetic acid for example, esters such as ethyl acetate by for example, ethers such as tetrahydrofuran, for example, water and a mixture of these solvents. Advantageously, the alcohols are chosen from methanol, ethanol and isopropanol.
De préférence, le solvant apolaire est choisi dans le groupe comprenant le dichlorométhane et le dichloro-1 ,2-éthane.  Preferably, the apolar solvent is chosen from the group comprising dichloromethane and 1,2-dichloroethane.
De préférence, le catalyseur à base palladium est choisi dans le groupe constitué par le palladium sur charbon, l'hydroxyde de palladium et l'acétate de palladium.  Preferably, the palladium catalyst is selected from the group consisting of palladium on carbon, palladium hydroxide and palladium acetate.
De préférence, la pression d'hydrogène utilisée dans les procédés de l'invention est comprise entre 1 et 10 bars.  Preferably, the hydrogen pressure used in the processes of the invention is between 1 and 10 bar.
Dans un autre mode de réalisation particulier, le composé répondant à la formule générale (7a) In another particular embodiment, the compound corresponding to the general formula (7a)
(7a) j (7a) j
dans laquelle X représente un atome d'oxygène ou un atome de soufre est obtenu p réaction du résorcinol avec une heterocycloalkanone répondant à la formule générale (3a) in which X represents an oxygen atom or a sulfur atom is obtained reaction of resorcinol with a heterocycloalkanone corresponding to the general formula (3a)
(3a)  (3a)
dans un solvant polaire et en présence d'une base. in a polar solvent and in the presence of a base.
Dans un autre mode de réalisation particulier, le composé répondant à la formule générale (7b) In another particular embodiment, the compound corresponding to the general formula (7b)
(7b)  (7b)
dans laquelle X représente un atome d'oxygène ou un atome de soufre est obtenu par réaction du résorcinol avec une heterocycloalkanone répondant à la formule générale (3b) dans un solvant polaire et en présence d'un base. in which X represents an oxygen atom or a sulfur atom is obtained by reacting resorcinol with a heterocycloalkanone corresponding to the general formula (3b) in a polar solvent and in the presence of a base.
De préférence, la base est choisie dans le groupe comprenant l'hydroxyde de sodium, l'hydroxyde de potassium, l'hydroxyde de lithium et les alcoolates de métaux, de préférence le méthanolate de sodium et le tert-butylate de potassium. Avantageusement, la base est l'hydroxyde de sodium ou l'hydroxyde de potassium.  Preferably, the base is selected from the group consisting of sodium hydroxide, potassium hydroxide, lithium hydroxide and metal alkoxides, preferably sodium methanolate and potassium tert-butoxide. Advantageously, the base is sodium hydroxide or potassium hydroxide.
De préférence, le solvant polaire est choisi dans le groupe comprenant l'eau et les alcools, de préférence le méthanol, l'éthanol, et l'isopropanol. Avantageusement, le solvant polaire est l'eau.  Preferably, the polar solvent is selected from the group consisting of water and alcohols, preferably methanol, ethanol, and isopropanol. Advantageously, the polar solvent is water.
De préférence, le résorcinol et l'hétérocycloalkanone (3a) ou (3b) sont utilisés dans un rapport molaire résorcinol/hétérocycloalkanone compris entre 1 et 8.  Preferably, resorcinol and heterocycloalkanone (3a) or (3b) are used in a resorcinol / heterocycloalkanone molar ratio of between 1 and 8.
Un autre objet de l'invention concerne le com osé de formule générale (7a) ou (7b) Another subject of the invention relates to the compound of general formula (7a) or (7b)
(7a) (7b)  (7a) (7b)
dans laquelle X représente un atome d'oxygène ou un atome de soufre. De préférence le composé est choisi dans le groupe constitué par le 4-(4-Hydroxy-tetrahydro-pyran-4-yl)- benzene-1 ,3-diol et le 4-(3-Hydroxy-tetrahydro-pyran-3-yl)-benzene-1 ,3-diol. wherein X represents an oxygen atom or a sulfur atom. Preferably, the compound is selected from the group consisting of 4- (4-hydroxy-tetrahydro-pyran-4-yl) benzene-1,3-diol and 4- (3-hydroxy-tetrahydro-pyran-3- yl) -benzene-1,3-diol.
Le nouveau procédé de synthèse de 4-(hétérocycloalkyl)-benzene-1 ,3-diol (I) ou (II), de l'invention et tel qu'illustré aux figures 3 et 4, présente l'avantage d'être une synthèse courte comprenant au maximum une séquence linéaire de 2 étapes. The novel process for the synthesis of 4- (heterocycloalkyl) -benzene-1,3-diol (I) or (II), of the invention and as illustrated in FIGS. 3 and 4, has the advantage of being a short synthesis comprising at most a linear sequence of 2 steps.
Cette nouvelle voie de synthèse utilise le résorcinol (6) comme produit de départ, ce qui, économiquement, est très avantageux comparé au prix du 2,4-dihydroxy bromobenzene (1 ). This new synthetic route uses resorcinol (6) as a starting material, which is economically very advantageous compared to the price of 2,4-dihydroxybromobenzene (1).
La première étape de cette nouvelle voie de synthèse est une étape originale de couplage du résorcinol (6) avec les hétérocycloalkanones (3a) ou (3b) en présence d'une base. La base utilisée est choisie de préférence dans le groupe comprenant l'hydroxyde de sodium, l'hydroxyde de potassium, l'hydroxyde de lithium et les alcoolates de métaux comme le méthanolate de sodium ou le tert-butylate de potassium par exemple. Cette étape est réalisée dans un solvant polaire, de préférence dans l'eau ou dans des alcools, et permet d'obtenir directement les composés (7a) ou (7b) respectivement. Les alcools sont choisis de préférence dans le groupe comprenant le méthanol, l'éthanol et l'isopropanol. The first step of this new synthetic route is an original step of coupling resorcinol (6) with heterocycloalkanones (3a) or (3b) in the presence of a base. The base used is preferably selected from the group consisting of sodium hydroxide, potassium hydroxide, lithium hydroxide and metal alkoxides. sodium methanolate or potassium tert-butoxide, for example. This step is carried out in a polar solvent, preferably in water or in alcohols, and allows the compounds (7a) or (7b) to be obtained directly, respectively. The alcohols are preferably selected from the group comprising methanol, ethanol and isopropanol.
Lors de cette première étape, un excès de résorcinol (6) est de préférence utilisé pour réagir sur l'hétérocycloalkanone (3a) ou (3b). Plus spécifiquement, le rapport molaire résorcinol/hétérocycloalkanone est compris entre 1 et 8 et, de préférence, entre 2 et 4.  In this first step, an excess of resorcinol (6) is preferably used to react on the heterocycloalkanone (3a) or (3b). More specifically, the resorcinol / heterocycloalkanone molar ratio is between 1 and 8 and preferably between 2 and 4.
La température à laquelle est effectuée cette étape de couplage représente un autre avantage de cette nouvelle voie de synthèse. En effet, cette première étape est réalisée à température ambiante, dans l'eau ou dans les alcools, ce qui permet d'éviter l'étape cryogénique (de l'ordre de -70°C) du procédé divulgué dans WO 2010/063773. D'autre part, les intermédiaires réactionnels (7a) ou (7b) sont obtenus sous forme cristalline après neutralisation du milieu et permet de s'affranchir des étapes de purification. Ainsi, la séparation sur une colonne de chromatographie pour isoler les intermédiaires réactionnels (7a) ou (7b)  The temperature at which this coupling step is performed represents another advantage of this new synthetic route. Indeed, this first step is carried out at ambient temperature, in water or in alcohols, which makes it possible to avoid the cryogenic step (of the order of -70 ° C.) of the process disclosed in WO 2010/063773 . On the other hand, the reaction intermediates (7a) or (7b) are obtained in crystalline form after neutralization of the medium and makes it possible to dispense with the purification steps. Thus, the separation on a chromatography column to isolate the reaction intermediates (7a) or (7b)
(7a) (7b)  (7a) (7b)
n'est pas nécessaire, ce qui constitue un autre avantage pour la transposition de ce procédé à une échelle industrielle. Il est préférable d'avoir un pH égal à 7 ou un pH de 7 à 8. De manière préférentielle le pH est égal à 7. is not necessary, which is another advantage for the transposition of this process on an industrial scale. It is preferable to have a pH equal to 7 or a pH of 7 to 8. Preferably the pH is equal to 7.
La seconde étape de cette nouvelle voie de synthèse est une étape d'hydrogénation ou de réduction des intermédiaires (7a) ou (7b) pour obtenir respectivement les composés de formule (I) ou (II). The second step of this new synthesis route is a hydrogenation or reduction step of the intermediates (7a) or (7b) to obtain the compounds of formula (I) or (II), respectively.
Dans le cas où X représente un atome d'oxygène, l'hydrogénation des intermédiaires (7a) ou (7b) est réalisée dans un solvant polaire. Les solvants polaires préférés sont choisis dans le groupe comprenant les alcools comme le méthanol par exemple, les acides carboxyliques comme l'acide acétique par exemple, les esters comme l'acétate d'éthyle par exemple, les éthers comme le tetrahydrofuranne par exemple, l'eau et un mélange de ces solvants. Les alcools sont choisis de préférence dans le groupe comprenant le méthanol, l'éthanol et l'isopropanol. In the case where X represents an oxygen atom, the hydrogenation of the intermediates (7a) or (7b) is carried out in a polar solvent. Preferred polar solvents are selected from the group consisting of alcohols such as methanol for example, carboxylic acids such as acetic acid for example, esters such as ethyl acetate for example, ethers such as tetrahydrofuran for example, water and a mixture of these solvents. The alcohols are preferably selected from the group comprising methanol, ethanol and isopropanol.
L'hydrogénation est réalisée en présence d'un catalyseur à base de palladium. Les catalyseurs préférés sont choisis dans le groupe constitué par le palladium sur charbon, l'hydroxyde de palladium, l'acétate de palladium, ou encore tout autre catalyseur de réduction connu de l'homme du métier. La pression d'hydrogène utilisée est comprise entre 1 et 10 bars et de préférence entre 3 et 7 bars. Dans le cas où X représente un atome de soufre, la réduction des intermédiaires (7a) ou (7b) est réalisée dans un solvant apolaire. Les solvants apolaires préférés sont choisis dans le groupe comprenant le dichlorométhane et le dichloro-1 ,2-éthane. La réduction est réalisée en présence d'un réducteur de type hydrure de silicium et d'un acide de Lewis. Les réducteurs préférés sont choisis dans le groupe constitué par le triethylsilane, le polymethylhydrosiloxane (PMHS) et encore tout autre hydrure de silicium connu de l'homme du métier. Les acides de Lewis préférés sont choisis dans le groupe constitué par le trifluorure de bore et ses complexes comme par exemple l'éthérate de trifluoroborane. The hydrogenation is carried out in the presence of a palladium-based catalyst. The preferred catalysts are selected from the group consisting of palladium on carbon, palladium hydroxide, palladium acetate, or any other reduction catalyst known to those skilled in the art. The hydrogen pressure used is between 1 and 10 bar and preferably between 3 and 7 bar. In the case where X represents a sulfur atom, the reduction of the intermediates (7a) or (7b) is carried out in an apolar solvent. Preferred apolar solvents are selected from the group consisting of dichloromethane and 1,2-dichloroethane. The reduction is carried out in the presence of a silicon hydride reducing agent and a Lewis acid. The preferred reducing agents are selected from the group consisting of triethylsilane, polymethylhydrosiloxane (PMHS) and any other silicon hydride known to those skilled in the art. The preferred Lewis acids are selected from the group consisting of boron trifluoride and its complexes such as, for example, trifluoroborane etherate.
Description des Figures Description of the Figures
Figure 1 : Préparation des composés de formule (I) décrite dans WO 2010/063773 Figure 1: Preparation of compounds of formula (I) described in WO 2010/063773
Figure 2 : Préparation des composés de formule (II) décrite dans WO 2010/063773 Figure 2: Preparation of compounds of formula (II) described in WO 2010/063773
Figure 3: Procédé de préparation des composés de l'invention de formule (I) FIG. 3: Process for preparing the compounds of the invention of formula (I)
Figure 4: Procédé de préparation des composés de l'invention de formule (II) Exemples FIG. 4: Process for preparing the compounds of the invention of formula (II) Examples
Les exemples suivants sont maintenant présentés en vue d'illustrer le procédé tel que décrit précédemment. Ces exemples qui illustrent le procédé de l'invention ne sont pas limitatifs.  The following examples are now presented to illustrate the process as described above. These examples which illustrate the process of the invention are not limiting.
Exemple 1 : cas X = O : 4-(Tetrahydro-pyran-4-yl)-benzene-1,3-diol a) 4-(4-Hydroxy-tetrahydro-pyran-4-yl)-benzene-1,3-diol Example 1: Case X = O: 4- (Tetrahydro-pyran-4-yl) -benzene-1,3-diol a) 4- (4-Hydroxy-tetrahydro-pyran-4-yl) -benzene-1,3 diol
Dans un réacteur double enveloppe de 6 L, 550 g (5 moles, 4eq) de résorcinol sont chargés sous azote puis 1530 ml d'une solution de soude 3M sont ajoutés en maintenant la température à 17°C. 125 g de tetrahydro-4-pyranon-4-one (1 .25 mol, 1 eq) sont ajoutés au milieu réactionnel. Le mélange est alors agité 2 heures à température ambiante, l'avancement de la réaction est contrôlé par plaque CCM (éluant hept /AcOEt 2/1 ). La réaction est arrêtée par l'ajout d'une solution d'acide chlorhydrique 2M jusqu'à obtenir un pH = 7 (pH mètre). 830 g de NaCI sont alors ajoutés et le milieu réactionnel est agité une nuit à température ambiante. Le solide est filtré puis lavé trois fois avec 11 d'eau. Le solide est essoré puis séché sous vide à 50°C une nuit pour fournir 125 g de 4-(4-hydroxy-tetrahydro- pyran-4-yl)-benzene-1 ,3-diol sous forme de poudre blanche cristalline. Rdt = 48%.  In a 6 L jacketed reactor, 550 g (5 moles, 4 eq) of resorcinol are charged under nitrogen and then 1530 ml of a 3M sodium hydroxide solution are added while maintaining the temperature at 17 ° C. 125 g of tetrahydro-4-pyranon-4-one (1.25 mol, 1 eq) are added to the reaction medium. The mixture is then stirred for 2 hours at room temperature, the progress of the reaction is controlled by TLC plate (eluent hept / AcOEt 2/1). The reaction is stopped by adding a 2M hydrochloric acid solution until a pH = 7 (pH meter). 830 g of NaCl are then added and the reaction medium is stirred overnight at room temperature. The solid is filtered and washed three times with 11 parts of water. The solid was drained and dried under vacuum at 50 ° C overnight to provide 125 g of 4- (4-hydroxy-tetrahydropyran-4-yl) benzene-1,3-diol as a white crystalline powder. Yield = 48%.
Tf = 152°C RMN Ή (DMSO D6, 400 MHz): 1 .50 (m, 2H) ; 2.21 (m, 2H) ; 3.69 (m, 4H) ; 5.50 (si, 1 H) ; 6.20 (m, 2H) ; 7.16 (d, J = 8 Hz, 1 H) ; 6.82 (d, J = 8.4 Hz, 1 H) ; 8.95 (s, 1 H) ; 9.1 1 (si, 2H). b) 4-(Tetrahydro-pyran-4-yl)-benzene-1,3-diol Mp = 152 ° C NMR Ή (DMSO D6, 400 MHz): 1.50 (m, 2H); 2.21 (m, 2H); 3.69 (m, 4H); 5.50 (si, 1H); 6.20 (m, 2H); 7.16 (d, J = 8 Hz, 1H); 6.82 (d, J = 8.4 Hz, 1H); 8.95 (s, 1H); 9.1 1 (si, 2H). b) 4- (Tetrahydro-pyran-4-yl) -benzene-1,3-diol
Dans un réacteur de PARR sous azote, 100 g (0.47 mol) de 4-(4-hydroxy-tetrahydro-pyran- 4-yl)-benzene-1 ,3-diol sont placés suivis par 100 mL d'acide acétique ainsi que 10 g de palladium sur charbon à 10%. 400 mL de THF sont ajoutés et le milieu réactionnel est agité 5 heures sous 5 bars d'hydrogène et à température ambiante. La solution est alors filtrée sur clarcel, le clarcel est lavé avec 250 ml de THF puis le filtrat est concentré jusqu'à obtenir un volume final de150 mL. 50 mL d'acétate d'éthyle sont alors ajoutés et le mélange réactionnel est agité une heure à 0°C. Le solide est filtré puis lavé avec 50 ml d'acétate d'éthyle supplémentaire puis séché sous vide pour fournir 84 g de 4-(Tetrahydro-pyran-4-yl)- benzene-1 ,3-diol sous forme de produit cristallin. Rdt = 92%. In a PARR reactor under nitrogen, 100 g (0.47 mol) of 4- (4-hydroxy-tetrahydro-pyran-4-yl) -benzene-1,3-diol are placed followed by 100 ml of acetic acid and 10 g of 10% palladium on carbon. 400 mL of THF are added and the reaction mixture is stirred for 5 hours under 5 bar of hydrogen and at room temperature. The solution is then filtered on clarcel, the clarcel is washed with 250 ml of THF and the filtrate is concentrated to a final volume of 150 ml. 50 ml of ethyl acetate are then added and the reaction mixture is stirred for one hour at 0 ° C. The solid is filtered and then washed with 50 ml of additional ethyl acetate and then dried under vacuum to provide 84 g of 4- (Tetrahydro-pyran-4-yl) -benzene-1,3-diol as a crystalline product. Yld = 92%.
Tf = 223 °C Mp = 223 ° C
RMN Ή (DMSO D6, 400 MHz): 1 .54 (m, 4H) ; 2.92 ( m, 1 H) ; 3.39 (m, 2H) ; 3.90 (m, 2H) ; 6.14 (dd, J = 8.4 & 2.4 Hz, 1 H) ; 6.25 (d, J = 2.4 Hz, 1 H) ; 6.82 (d, J = 8.4 Hz, 1 H) ; 8.95 (s, 1 H) ; 9.1 1 (s, 1 H). NMR Ή (DMSO D6, 400 MHz): 1.54 (m, 4H); 2.92 (m, 1H); 3.39 (m, 2H); 3.90 (m, 2H); 6.14 (dd, J = 8.4 & 2.4 Hz, 1H); 6.25 (d, J = 2.4 Hz, 1H); 6.82 (d, J = 8.4 Hz, 1H); 8.95 (s, 1H); 9.1 1 (s, 1H).
RMN 13C (DMSO D6, 100 MHz) : 32.6, 33.5, 67.7, 102.3, 106.0, 122.4, 126.7, 155.2, 156.0. 13 C NMR (DMSO D6, 100 MHz): 32.6, 33.5, 67.7, 102.3, 106.0, 122.4, 126.7, 155.2, 156.0.
Exemple 2: cas X = S : 4-(Tetrahydro-thiopyran-4-yl)-benzene-1,3-diol a) 4-(4-hydroxy-tetrahydro-thiopyran-4-yl)-benzene-1,3-diol Example 2: Case X = S: 4- (Tetrahydro-thiopyran-4-yl) -benzene-1,3-diol a) 4- (4-hydroxy-tetrahydro-thiopyran-4-yl) -benzene-1,3 diol
13.43 g (0.1 15 mol, 1 éq) de tétrahydro-thiopyran-4-one en suspension dans 100 mL d'eau sont ajoutés sur un mélange dégazé de 25.45 g (0.231 mol, 2.0 éq) de résorcinol solubilisés dans 1 15 mL (0.231 mol, 2.0 éq) d'hydroxyde de sodium 2N. Le milieu réactionnel est agité à température ambiante pendant 2 heures et 30 minutes. Le milieu réactionnel est traité avec 100 mL d'une solution d'acide chlorhydrique 2N (pH 5) et extrait à l'acétate d'éthyle. Les phases organiques sont rassemblées, séchées sur sulfate de magnésium, filtrées et évaporées. 40.88 g d'huile jaune sont obtenus.  13.43 g (0.1 mol, 1 eq) of tetrahydro-thiopyran-4-one in suspension in 100 ml of water are added to a degassed mixture of 25.45 g (0.231 mol, 2.0 eq) of resorcinol solubilized in 15 ml ( 0.231 mol, 2.0 eq) of 2N sodium hydroxide. The reaction medium is stirred at room temperature for 2 hours and 30 minutes. The reaction medium is treated with 100 ml of a 2N hydrochloric acid solution (pH 5) and extracted with ethyl acetate. The organic phases are combined, dried over magnesium sulfate, filtered and evaporated. 40.88 g of yellow oil are obtained.
Cette huile est solubilisée dans 1 L de dichlorométhane et engagée dans l'étape suivante. b) 4-(Tétrahydro-thiopyran-4-yl)-benzène-1,3-diol 55 mL (0.345 mol, 3 éq) de triéthylsilane suivis de 44 mL (0.345 mol, 3 éq) d'éthérate de trifluoroborane sont ajoutés goutte à goutte sur une solution (0.1 15 mol, 1 éq) de 4-(4- hydroxy-tetrahydro-thiopyran-4-yl)-benzene-1 ,3-diol brut tel qu'obtenu à l'étape précédente dans 1 L de dichlorométhane. Le milieu réactionnel est agité à température ambiante pendant 10 minutes. 400 mL d'eau sont ajoutés dans le milieu réactionnel suivis de 250 mL d'une solution saturée d'hydrogénocarbonate de sodium. Le mélange est décanté et la phase aqueuse est extraite avec du dichlorométhane. Les phases organiques sont rassemblées, lavées à l'eau, séchées sur sulfate de magnésium et concentrées. L'insoluble est filtré. 6.85g de 4-(tétrahydro-thiopyran-4-yl)-benzène-1 ,3-diol sont obtenus sous forme d'une poudre blanche. Rendement = 28% sur les deux étapes This oil is solubilized in 1 L of dichloromethane and engaged in the next step. b) 4- (Tetrahydro-thiopyran-4-yl) -benzene-1,3-diol 55 ml (0.345 mol, 3 eq) of triethylsilane followed by 44 ml (0.345 mol, 3 eq) of trifluoroborane etherate are added dropwise to a solution (0.1 15 mol, 1 eq) of 4- (4-hydroxy crude tetrahydro-thiopyran-4-yl) -benzene-1,3-diol as obtained in the previous step in 1 L of dichloromethane. The reaction medium is stirred at room temperature for 10 minutes. 400 ml of water are added to the reaction medium followed by 250 ml of a saturated solution of sodium hydrogencarbonate. The mixture is decanted and the aqueous phase is extracted with dichloromethane. The organic phases are combined, washed with water, dried over magnesium sulfate and concentrated. The insoluble is filtered. 6.85 g of 4- (tetrahydro-thiopyran-4-yl) -benzene-1,3-diol are obtained in the form of a white powder. Yield = 28% on both stages
Tf = 171 °C Mp = 171 ° C
RMN Ή ÎDMSO D6, 400 MHz): 1 .61 (m, 2H) ; 1 .92 (m, 2H) ; 2.55 (m, 2H) , 2.72 (m, 3H) ; 6.14 (dd, J = 8.4 & 2.4 Hz, 1 H) ; 6.25 (d, J = 2.4 Hz, 1 H) ; 6.80 (d, J = 8.4 Hz, 1 H) ; 8.95 (s, 1 H) ; 9.10 (s, 1 H). 1H NMR δ DMSO (400 MHz): 1.61 (m, 2H); 1.92 (m, 2H); 2.55 (m, 2H), 2.72 (m, 3H); 6.14 (dd, J = 8.4 & 2.4 Hz, 1H); 6.25 (d, J = 2.4 Hz, 1H); 6.80 (d, J = 8.4 Hz, 1H); 8.95 (s, 1H); 9.10 (s, 1H).
RMN 13C ÎDMSO D6, 100 MHz) : 28.7, 33.8, 35.6, 102.3, 106.0, 123.5, 126.7, 154.8, 156.0. 13 DMSO D6 NMR, 100 MHz): 28.7, 33.8, 35.6, 102.3, 106.0, 123.5, 126.7, 154.8, 156.0.
Exemple 3 : cas X = O : 4-(3-Hvdroxy-tétrahvdro-pyran-3-yl)-benzène-1,3-diol a ) 4-(3-hydroxy-tétrahydro-pyran-3-yl)-benzène-1, 3-diol Example 3: X = O: 4- (3-hydroxy-tetrahydro-pyran-3-yl) -benzene-1,3-diol a) 4- (3-hydroxy-tetrahydro-pyran-3-yl) -benzene -1, 3-diol
2.1 g (0.02 mol, 1 éq) de dihydro-pyran-3-one en solution dans 2 mL d'eau sont ajoutés goutte à goutte sur un mélange dégazé de 8.8 g (0.08 mol, 4.0 éq) de résorcinol solubilisés dans 25 mL (0.075 mol, 3.7 éq) d'hydroxyde de sodium 3N. Le milieu réactionnel est agité à température ambiante pendant 1 heure. Le milieu réactionnel est traité avec 5 mL d'une solution d'acide chlorhydrique concentré (pH 7) et 9 g de chlorure de sodium sont ajoutés. Le mélange est refroidi dans un bain de glace et extrait à l'acétate d'éthyle. Les phases organiques sont rassemblées, séchées sur sulfate de magnésium, filtrées et évaporées. Le résidu est chromatographié sur gel de silice (colonne AnaLogix SF40-150g, Spot II) élué à l'heptane/acétate d'éthyle 80/20 puis 20/80. 2.91 g de 4-(3-hydroxy-tétrahydro-pyran-3-yl)- benzène-1 , 3-diol sont obtenus sous forme d'un solide amorphe blanc. Rendement = 69% b) 4-(Tétrahydro-pyran-3-yl)-benzène- 1, 3-diol Un mélange de 2.9 g (0.14 mol, 1 éq) de 4-(3-hydroxy-tétrahydro-pyran-3-yl)-benzène-1 ,3- diol dans 60 mL d'acétate d'éthyle et 6 mL de méthanol en présence de 580 mg (20% en masse) de palladium sur charbon à 10% est agité sous pression d'hydrogène de 5 bars à température ambiante pendant 5 heures puis chauffé à 50°C pendant 24 heures (formation de 10% de produit). 580 mg (20% en masse) de palladium sur charbon à 10% sont rajoutés et le milieu réactionnel est chauffé à 60°C sous pression d'hydrogène de 5 bars pendant 6 jours. 580 mg (20% en masse) de palladium sur charbon à 10% sont rajoutés et le milieu réactionnel est chauffé à 60°C sous pression d'hydrogène de 5 bars pendant 24 heures. Le milieu réactionnel est filtré sur papier filtre et le filtrat est évaporé. Le résidu est chromatographié sur gel de silice (colonne AnaLogix SF40-150g, Spot II) élué à l'heptane/acétate d'éthyle 78/22 à 50/50. L'huile obtenue est cristallisée dans dichlorométhane/heptane, filtré et séché sous vide à 40°C. 1 .21 g de 4-(tétrahydro-pyran-3- yl)-benzène-1 ,3-diol sont obtenus sous forme d'un solide blanc. (Tf = 148-149°C). Rendement = 44% 2.1 g (0.02 mol, 1 eq) of dihydro-pyran-3-one dissolved in 2 ml of water are added dropwise to a degassed mixture of 8.8 g (0.08 mol, 4.0 eq) of resorcinol solubilized in 25 ml. (0.075 mol, 3.7 eq) of 3N sodium hydroxide. The reaction medium is stirred at room temperature for 1 hour. The reaction medium is treated with 5 ml of a concentrated hydrochloric acid solution (pH 7) and 9 g of sodium chloride are added. The mixture is cooled in an ice bath and extracted with ethyl acetate. The organic phases are combined, dried over magnesium sulfate, filtered and evaporated. The residue is chromatographed on silica gel (AnaLogix SF40-150g column, Spot II) eluted with heptane / ethyl acetate 80/20 then 20/80. 2.91 g of 4- (3-hydroxy-tetrahydro-pyran-3-yl) -benzene-1,3-diol are obtained in the form of a white amorphous solid. Yield = 69% b) 4- (Tetrahydro-pyran-3-yl) -benzene-1,3-diol A mixture of 2.9 g (0.14 mol, 1 eq) of 4- (3-hydroxy-tetrahydro-pyran-3) -yl) -benzene-1,3-diol in 60 ml of ethyl acetate and 6 ml of methanol in the presence of 580 mg (20% by weight) of 10% palladium on carbon is stirred under hydrogen pressure from 5 bars to room temperature for 5 hours and then heated at 50 ° C for 24 hours (formation of 10% product). 580 mg (20% by weight) of 10% palladium on charcoal are added and the reaction medium is heated at 60 ° C. under hydrogen pressure of 5 bar for 6 days. 580 mg (20% by weight) of palladium on charcoal at 10% are added and the reaction medium is heated at 60 ° C under hydrogen pressure of 5 bar for 24 hours. The reaction medium is filtered on filter paper and the filtrate is evaporated. The residue is chromatographed on silica gel (AnaLogix SF40-150g column, Spot II) eluted with heptane / ethyl acetate 78/22 at 50/50. The oil obtained is crystallized from dichloromethane / heptane, filtered and dried under vacuum at 40 ° C. 1.2 g of 4- (tetrahydro-pyran-3-yl) -benzene-1,3-diol are obtained in the form of a white solid. (Mp = 148-149 ° C). Yield = 44%
RMN 1H ÎDMSO D6, 400 MHz): 1 .54-1 .77 (m, 4H) ; 2.94 (m, 1 H) ; 3.12 (t, J = 10.6 Hz, 1 H) ; 3.30 (m, 1 H) , 3.75 (m, 1 H) ; 3.81 (d, J = 1 1 Hz, 1 H); 6.15 (dd, J = 8.4 & 2.4 Hz, 1 H) ; 6.26 (d, J = 2.4 Hz, 1 H) ; 6.84 (d, J = 8.4 Hz, 1 H) ; 9.00 (s, 1 H) ; 9.18 (s, 1 H). 1 H NMR idMso D6, 400 MHz): 1 .54-1 .77 (m, 4H); 2.94 (m, 1H); 3.12 (t, J = 10.6 Hz, 1H); 3.30 (m, 1H), 3.75 (m, 1H); 3.81 (d, J = 11 Hz, 1H); 6.15 (dd, J = 8.4 & 2.4 Hz, 1H); 6.26 (d, J = 2.4 Hz, 1H); 6.84 (d, J = 8.4 Hz, 1H); 9.00 (s, 1H); 9.18 (s, 1H).
RMN 13C ÎDMSO D6, 100 MHz) : 26.2; 28.8; 34.9; 67.2; 72.1 ; 102.3; 106.0; 1 19.0; 127.3; 155.6; 156.4. 13 C NMR DMSO D6, 100 MHz): 26.2; 28.8; 34.9; 67.2; 72.1; 102.3; 106.0; 19.0; 127.3; 155.6; 156.4.

Claims

REVENDICATIONS
1. Procédé de synthèse d'un 4-(hétérocycloalkyl)-benzene-1 ,3-diol répondant à la formule générale (I) A process for the synthesis of a 4- (heterocycloalkyl) -benzene-1,3-diol corresponding to the general formula (I)
dans laquelle X représente un atome d'oxygène ou de soufre, caractérisé en ce que un composé répondant à la formule générale 7a) in which X represents an oxygen or sulfur atom, characterized in that a compound corresponding to the general formula 7a)
(7a) réagit avec de l'hydrogène en présence d'un catalyseur à base de palladium dans un solvant polaire lorsque X représente un atome d'oxygène ou avec un réducteur de type hydrure de silicium et un acide de Lewis dans un solvant apolaire lorsque X représente un atome de soufre.  (7a) reacts with hydrogen in the presence of a palladium catalyst in a polar solvent when X is an oxygen atom or with a silicon hydride reducing agent and a Lewis acid in an apolar solvent when X represents a sulfur atom.
2. Procédé de synthèse d'un 4-(heterocycloalkyl)-benzene-1 ,3-diol répondant à la formule générale (II) 2. Process for the synthesis of a 4- (heterocycloalkyl) -benzene-1,3-diol corresponding to the general formula (II)
dans laquelle X représente un atome d'oxygène ou de soufre, caractérisé en ce que un composé répondant à la formule générale (7b) in which X represents an oxygen or sulfur atom, characterized in that a compound corresponding to the general formula (7b)
(7b) réagit avec de l'hydrogène en présence d'un catalyseur à base de palladium dans un solvant polaire lorsque X représente un atome d'oxygène ou avec un réducteur de type hydrure de silicium et un acide de Lewis dans un solvant apolaire lorsque X représente un atome de soufre.  (7b) reacts with hydrogen in the presence of a palladium catalyst in a polar solvent when X represents an oxygen atom or with a silicon hydride reducing agent and a Lewis acid in an apolar solvent when X represents a sulfur atom.
3. Procédé selon la revendication 1 ou 2, caractérisé en ce que le solvant polaire est choisi dans le groupe comprenant les alcools, de préférence le méthanol, les acides carboxyliques, de préférence l'acide acétique, les esters, de préférence l'acétate d'éthyle, les éthers, de préférence le tetrahydrofuranne, l'eau et un mélange de ces solvants. 3. Method according to claim 1 or 2, characterized in that the polar solvent is selected from the group comprising alcohols, preferably methanol, carboxylic acids, preferably acetic acid, esters, preferably acetate ethers, ethers, preferably tetrahydrofuran, water and a mixture of these solvents.
4. Procédé selon la revendication 3, caractérisé en ce que les alcools sont choisis dans le groupe comprenant le méthanol, l'éthanol et l'isopropanol. 4. Process according to claim 3, characterized in that the alcohols are chosen from the group comprising methanol, ethanol and isopropanol.
5. Procédé selon la revendication 1 ou 2, caractérisé en ce que le solvant apolaire est choisi dans le groupe comprenant le dichlorométhane et le dichloro-1 ,2-éthane. 5. Method according to claim 1 or 2, characterized in that the apolar solvent is selected from the group comprising dichloromethane and 1,2-dichloroethane.
6. Procédé selon la revendication 1 ou 2, caractérisé en ce que le catalyseur à base de palladium est choisi dans le groupe constitué par le palladium sur charbon, l'hydroxyde de palladium et l'acétate de palladium. 6. Process according to claim 1 or 2, characterized in that the palladium catalyst is selected from the group consisting of palladium on carbon, palladium hydroxide and palladium acetate.
7. Procédé selon la revendication 1 ou 2, caractérisé en ce que la pression d'hydrogène utilisée est comprise entre 1 et 10 bars. 7. Method according to claim 1 or 2, characterized in that the hydrogen pressure used is between 1 and 10 bar.
8. Procédé selon la revendication 1 , caractérisé en ce que le composé répondant à la formule générale (7a) 8. Process according to claim 1, characterized in that the compound corresponding to the general formula (7a)
(7a) dans laquelle X représente un atome d'oxygène ou un atome de soufre est obtenu par réaction du résorcinol avec une heterocycloalkanone répondant à la formule générale (3a) (7a) in which X represents an oxygen atom or a sulfur atom is obtained by reacting resorcinol with a heterocycloalkanone corresponding to the general formula (3a)
(3a)  (3a)
dans un solvant polaire et en présence d'une base. in a polar solvent and in the presence of a base.
9. Procédé selon la revendication 2, caractérisé en ce que le composé répondant à la formule générale (7b) 9. Process according to claim 2, characterized in that the compound corresponding to the general formula (7b)
(7b) dans laquelle X représente un atome d'oxygène ou un atome de soufre est obtenu par réaction du résorcinol avec une heterocycloalkanone répondant à la formule générale (3b) (7b) wherein X represents an oxygen atom or a sulfur atom is obtained by reacting resorcinol with a heterocycloalkanone corresponding to the general formula (3b)
(3b)  (3b)
dans un solvant polaire et en présence d'un base. in a polar solvent and in the presence of a base.
10. Procédé selon la revendication 8 ou 9, caractérisé en ce que la base utilisée est choisie dans le groupe comprenant l'hydroxyde de sodium, l'hydroxyde de potassium, l'hydroxyde de lithium et les alcoolates de métaux comme le methanolate de sodium ou le tert-butylate de potassium. 10. The method of claim 8 or 9, characterized in that the base used is selected from the group consisting of sodium hydroxide, potassium hydroxide, lithium hydroxide and metal alkoxides such as sodium methanolate or potassium tert-butoxide.
11. Procédé selon la revendication 10, caractérisé en ce que la base utilisée est choisie dans le groupe comprenant l'hydroxyde de sodium et l'hydroxyde de potassium. 11. The method of claim 10, characterized in that the base used is selected from the group comprising sodium hydroxide and potassium hydroxide.
12. Procédé selon la revendication 8 ou 9, caractérisé en ce que solvant polaire est choisi dans le groupe comprenant l'eau et les alcools, de préférence, le méthanol, l'éthanol ou l'isopropanol. 12. The method of claim 8 or 9, characterized in that polar solvent is selected from the group consisting of water and alcohols, preferably methanol, ethanol or isopropanol.
13. Procédé selon la revendication 12, caractérisé en ce que solvant polaire est l'eau. 13. The method of claim 12, characterized in that polar solvent is water.
14. Procédé selon la revendication 8 ou 9, caractérisé en ce que le résorcinol et l'heterocycloalkanone (3a) ou (3b) sont utilisés dans un rapport molaire résorcinol/heterocycloalkanone compris entre 1 et 8. 14. The method of claim 8 or 9, characterized in that resorcinol and heterocycloalkanone (3a) or (3b) are used in a molar ratio resorcinol / heterocycloalkanone between 1 and 8.
15. Composé de formule énérale (7a) ou (7b) 15. Compound of general formula (7a) or (7b)
(7a) (7b) dans laquelle X représente un atome d'oxygène ou un atome de soufre.  (7a) (7b) wherein X represents an oxygen atom or a sulfur atom.
16. Composé selon la revendication 15 caractérisé en ce qu'il est choisi dans le groupe constitué par le 4-(4-Hydroxy-tetrahydro-pyran-4-yl)-benzene-1 ,3-diol et le 4-(3-Hydroxy- tetrahydro-pyran-3-yl)-benzene-1 ,3-diol. 16. Compound according to claim 15, characterized in that it is selected from the group consisting of 4- (4-Hydroxy-tetrahydro-pyran-4-yl) -benzene-1,3-diol and 4- Hydroxytetrahydro-pyran-3-yl) -benzene-1,3-diol.
17. Procédé de synthèse selon la revendication 1 caractérisé en ce que X représente un atome d'oxygène. 17. Synthesis process according to claim 1 characterized in that X represents an oxygen atom.
EP14710599.3A 2013-02-14 2014-02-14 Process for the preparation of 4-(heterocycloalkyl)-benzene-1,3-diol compounds Active EP2956449B1 (en)

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US201361764638P 2013-02-14 2013-02-14
FR1351252 2013-02-14
PCT/FR2014/050312 WO2014125231A1 (en) 2013-02-14 2014-02-14 Method for the synthesis of 4-(heterocycloalkyl)-benzene-1,3-diol compounds

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FR2939136B1 (en) 2008-12-02 2010-12-03 Galderma Res & Dev NOVEL 4- (HETEROCYCLOALKYL) -BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN MEDICINE AND COSMETICS

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Title
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US20160185749A1 (en) 2016-06-30
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ES2635290T3 (en) 2017-10-03
WO2014125231A1 (en) 2014-08-21

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