EP2909319A4 - Hemmungsresistente polymerasen - Google Patents

Hemmungsresistente polymerasen

Info

Publication number
EP2909319A4
EP2909319A4 EP13847958.9A EP13847958A EP2909319A4 EP 2909319 A4 EP2909319 A4 EP 2909319A4 EP 13847958 A EP13847958 A EP 13847958A EP 2909319 A4 EP2909319 A4 EP 2909319A4
Authority
EP
European Patent Office
Prior art keywords
inhibition
resistant polymerases
polymerases
resistant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP13847958.9A
Other languages
English (en)
French (fr)
Other versions
EP2909319A1 (de
EP2909319B1 (de
Inventor
Milko B Kermekchiev
Zhian Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DNA Polymerase Technology Inc
Original Assignee
DNA Polymerase Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DNA Polymerase Technology Inc filed Critical DNA Polymerase Technology Inc
Priority to EP18166213.1A priority Critical patent/EP3366769B1/de
Publication of EP2909319A1 publication Critical patent/EP2909319A1/de
Publication of EP2909319A4 publication Critical patent/EP2909319A4/de
Application granted granted Critical
Publication of EP2909319B1 publication Critical patent/EP2909319B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
EP13847958.9A 2012-10-16 2013-10-16 Hemmungsresistente polymerasen Active EP2909319B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP18166213.1A EP3366769B1 (de) 2012-10-16 2013-10-16 Hemmungsresistente polymerasen

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261714671P 2012-10-16 2012-10-16
US201361811611P 2013-04-12 2013-04-12
PCT/US2013/065313 WO2014062848A1 (en) 2012-10-16 2013-10-16 Inhibition-resistant polymerases

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP18166213.1A Division EP3366769B1 (de) 2012-10-16 2013-10-16 Hemmungsresistente polymerasen
EP18166213.1A Division-Into EP3366769B1 (de) 2012-10-16 2013-10-16 Hemmungsresistente polymerasen

Publications (3)

Publication Number Publication Date
EP2909319A1 EP2909319A1 (de) 2015-08-26
EP2909319A4 true EP2909319A4 (de) 2016-10-12
EP2909319B1 EP2909319B1 (de) 2018-05-23

Family

ID=50485667

Family Applications (2)

Application Number Title Priority Date Filing Date
EP13847958.9A Active EP2909319B1 (de) 2012-10-16 2013-10-16 Hemmungsresistente polymerasen
EP18166213.1A Active EP3366769B1 (de) 2012-10-16 2013-10-16 Hemmungsresistente polymerasen

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP18166213.1A Active EP3366769B1 (de) 2012-10-16 2013-10-16 Hemmungsresistente polymerasen

Country Status (4)

Country Link
US (2) US10683537B2 (de)
EP (2) EP2909319B1 (de)
CA (2) CA2888455C (de)
WO (1) WO2014062848A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2909319B1 (de) 2012-10-16 2018-05-23 DNA Polymerase Technology, Inc. Hemmungsresistente polymerasen
WO2016100438A2 (en) * 2014-12-16 2016-06-23 Life Technologies Corporation Polymerase compositions and methods of making and using same
US11091745B2 (en) 2015-05-12 2021-08-17 Dna Polymerase Technology, Inc. Mutant polymerases and uses thereof
US10961518B2 (en) 2018-01-19 2021-03-30 Bio-Rad Laboratories, Inc. Mutant DNA polymerases
CN116200364A (zh) * 2019-03-10 2023-06-02 武汉爱博泰克生物科技有限公司 用于在提高的盐浓度或体液中扩增的突变型Taq聚合酶
US11613738B2 (en) * 2019-05-14 2023-03-28 Abclonal Science, Inc. Mutant Taq polymerase resistant to inhibition of amplification in the presence of cyanine dye
CN116064462A (zh) * 2022-08-26 2023-05-05 江苏伟禾生物科技有限公司 一种Taq DNA聚合酶突变体及其制备方法

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WO2005113829A2 (en) * 2004-05-20 2005-12-01 Kermekchiev Milko B Use of whole blood in pcr reactions
US20070048748A1 (en) * 2004-09-24 2007-03-01 Li-Cor, Inc. Mutant polymerases for sequencing and genotyping
WO2010062777A2 (en) * 2008-11-03 2010-06-03 Kapabiosystems Modified type a dna polymerases

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AU8906091A (en) * 1990-10-05 1992-04-28 Wayne M. Barnes Thermostable dna polymerase
EP1233061A3 (de) 1991-06-03 2002-09-04 Takara Shuzo Co., Ltd. Verfahren zum Klonieren eines Pol-I-Typ DNS-Polymerase-Gens
US6410277B1 (en) 1993-02-19 2002-06-25 Takara Shuzo Co., Ltd. DNA polymersases with enhanced length of primer extension
US5436149A (en) 1993-02-19 1995-07-25 Barnes; Wayne M. Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension
US5928866A (en) 1994-12-15 1999-07-27 Research Development Corporation Of Japan Method for preparing mutant genes
EP0870832A4 (de) 1995-12-27 2001-08-22 Takara Shuzo Co Neue dna polymerase
JP3819436B2 (ja) 1996-07-11 2006-09-06 タカラバイオ株式会社 部位特異的変異導入方法
US7231301B2 (en) 1997-01-31 2007-06-12 Japan Science And Technology Corporation Method and a system for predicting protein functional site, a method for improving protein function, and a function-modified protein
US6210885B1 (en) 1997-10-09 2001-04-03 Transgenomic, Inc. Modifying double stranded DNA to enhance separations by matched ion polynucleotide chromatography
JP4808361B2 (ja) 2000-07-28 2011-11-02 セレスター・レキシコ・サイエンシズ株式会社 新規ｄｎａ合成酵素
US6403341B1 (en) 2001-08-02 2002-06-11 Wayne M. Barnes Magnesium precipitate hot start method for PCR
CA2460546A1 (en) 2001-09-14 2003-03-27 Invitrogen Corporation Dna polymerases and mutants thereof
US7393635B2 (en) 2002-05-16 2008-07-01 Dna Polymerase Technology, Inc. Ribocloning: recombinant DNA construction using primers with ribo bases
US7666645B2 (en) * 2002-10-23 2010-02-23 Bio-Rad Laboratories, Inc. Sso7-polymerase conjugate proteins
US7417133B2 (en) * 2004-02-27 2008-08-26 Institut Pasteur Methods for obtaining thermostable enzymes, DNA polymerase I variants from Thermus aquaticus having new catalytic activities, methods for obtaining the same, and applications of the same
CN101213295B (zh) 2005-07-04 2011-12-14 赛利斯达雷克西克-赛恩斯株式会社 变异型pcna
JP4486009B2 (ja) 2005-08-10 2010-06-23 株式会社日立製作所 Ｄｎａリガーゼ変異体
AU2007296180A1 (en) 2006-09-14 2008-03-20 Dna Polymerase Technology Inc. Use of Taq polymerase mutant enzymes for DNA amplification in the presence of PCR inhibitors
MX2009002105A (es) 2006-09-22 2009-05-28 Tummy Shield Holdings Pty Ltd Dispositivo y sistema de sujecion de cinturon de seguridad.
JP4193997B1 (ja) 2007-12-05 2008-12-10 プレシジョン・システム・サイエンス株式会社 新規ｄｎａポリメラーゼ
US8481685B2 (en) 2008-11-03 2013-07-09 Kapa Biosystems Modified DNA polymerases
WO2010065924A1 (en) 2008-12-05 2010-06-10 Dna Polymerase Technology Inc. Compositions for improving gene amplification
WO2011014885A1 (en) 2009-07-31 2011-02-03 Agilent Technologies, Inc. Thermostable type-a dna polymerase mutants with increased polymerization rate and resistance to inhibitors
KR101773636B1 (ko) * 2009-11-19 2017-09-01 솔리스 바이오다인 폴리펩티드 안정성 및 활성을 증가시키는 조성물 및 관련된 방법
WO2012088479A2 (en) 2010-12-22 2012-06-28 Dna Polymerase Technology, Inc. Composition to overcome inhibitors in pcr and growth cultures
WO2013008898A1 (ja) 2011-07-12 2013-01-17 国立大学法人九州大学 新規dnaポリメラーゼ
GB201113430D0 (en) * 2011-08-03 2011-09-21 Fermentas Uab DNA polymerases
EP2742151B1 (de) * 2011-08-10 2017-10-25 Life Technologies Corporation Polymerasezusammensetzungen
BR112014019741A2 (pt) 2012-02-11 2020-12-22 Genentech, Inc Usos de um antagonista da via wnt, uso de uma terapia anticâncer, método de identificação de um indivíduo com câncer, métodos para prever, método de inibição da proliferação de uma célula de câncer, uso de um antagonista da translocação de r-spondina e antagonista da translocação de r-spondina isolado
EP2909319B1 (de) 2012-10-16 2018-05-23 DNA Polymerase Technology, Inc. Hemmungsresistente polymerasen
CN103266103B (zh) * 2012-11-08 2016-08-31 天津精耐特基因生物技术有限公司 用于扩增核糖核酸的方法及分析该方法中rna或dna模板的方法
EP2995681B1 (de) 2013-05-10 2019-01-02 Kyushu University, National University Corporation Neuartiges dns-spaltendes enzym
US11091745B2 (en) 2015-05-12 2021-08-17 Dna Polymerase Technology, Inc. Mutant polymerases and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040005594A1 (en) * 2000-09-13 2004-01-08 Medical Research Council Directed evolution method
WO2005113829A2 (en) * 2004-05-20 2005-12-01 Kermekchiev Milko B Use of whole blood in pcr reactions
US20070048748A1 (en) * 2004-09-24 2007-03-01 Li-Cor, Inc. Mutant polymerases for sequencing and genotyping
WO2010062777A2 (en) * 2008-11-03 2010-06-03 Kapabiosystems Modified type a dna polymerases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE Geneseq [online] 5 August 2010 (2010-08-05), "Thermus aquaticus mutant DNA polymerase protein #36.", XP002756262, retrieved from EBI accession no. GSP:AYC87109 Database accession no. AYC87109 *

Also Published As

Publication number Publication date
US20140113299A1 (en) 2014-04-24
CA2888455C (en) 2021-11-09
CA3131328A1 (en) 2014-04-24
US10683537B2 (en) 2020-06-16
CA2888455A1 (en) 2014-04-24
CA3131328C (en) 2023-10-24
EP2909319A1 (de) 2015-08-26
EP3366769A1 (de) 2018-08-29
EP2909319B1 (de) 2018-05-23
US20210147908A1 (en) 2021-05-20
EP3366769B1 (de) 2021-02-17
WO2014062848A1 (en) 2014-04-24

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