EP2897617A2 - Préparation médicinale comprenant un excipient avec du polyhexanide ou de l'octénidine - Google Patents

Préparation médicinale comprenant un excipient avec du polyhexanide ou de l'octénidine

Info

Publication number
EP2897617A2
EP2897617A2 EP13770871.5A EP13770871A EP2897617A2 EP 2897617 A2 EP2897617 A2 EP 2897617A2 EP 13770871 A EP13770871 A EP 13770871A EP 2897617 A2 EP2897617 A2 EP 2897617A2
Authority
EP
European Patent Office
Prior art keywords
carrier
polyhexanide
preparation according
octenidine
medicinal preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP13770871.5A
Other languages
German (de)
English (en)
Inventor
Wolfgang Winkelmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2897617A2 publication Critical patent/EP2897617A2/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Definitions

  • Medical preparation comprising a carrier
  • the present invention relates to pharmaceutical compositions, and more particularly to medicinal preparations containing a carrier and an antiseptic, wherein the antiseptic is selected from the group consisting of polyhexanide, octenidine and mixtures thereof.
  • the invention also relates to various products having a medical preparation according to the invention, as well as specific uses of the medicinal preparation.
  • Antiseptics are chemical substances that are used in medicine to prevent a wound infection and subsequently sepsis. To this end, various pathogens must be rapidly killed with sufficient certainty without harming the patient himself.
  • One group of antiseptics are specific quaternary ammonium compounds, such as polyhexanide and octenidine.
  • polyhexanide polyhexamethylene biguanide, poly (iminocarbonylimidoyl-iminocarbonylimidoylimino-1,6-hexanediyl) hydrochloride
  • PHMB polyhexamethylene biguanide
  • poly (iminocarbonylimidoyl-iminocarbonylimidoylimino-1,6-hexanediyl) hydrochloride) has been known for some time. In orthopedics and trauma surgery, it is considered the most widely used preparation. It is also used for poorly healing wounds and lavages. Polyhexanide is also part of surface disinfectant cleaners, pool cleaners and contact lens cleaning products. Polyhexanide has a broad spectrum of activity and wound healing is little affected by polyhexanide.
  • WO 2010/031096 A1 describes a liquid composition with 0.01% to 0.1% polyhexanide for use on the eye.
  • EP 0 468 122 A1 describes a therapeutic composition which Contains polyhexanide to treat the skin, eyes and genitals in case of a herpes infection.
  • DE 20 2006 016 821 U1 describes an absorption body which may, inter alia, also contain polyhexanide. Polyhexanide is also sometimes used in Suprasorb ® X wound dressings. However, a sufficient effect of polyhexanide is achieved only after an exposure time of at least 5 to 20 minutes.
  • Octenidine (N-octyl-1 - [10- (4-octyliminopyridin-1-yl) decyl] pyridine-4-imine) is also a quaternary ammonium compound used as a broad-spectrum antiseptic for the disinfection of skin and mucous membranes as well as for wound disinfection ,
  • DE 20 2010 007 433 U1 describes a gelatinous composition containing octenidine.
  • DE 10 2010 013 075 A1 describes a wound dressing which may contain, among other things, octenidine. However, a sufficient effect of octenidine is often only achieved after an exposure time of at least 5.
  • Polyhexanide and octenidine would be advantageous for a wide variety of applications as an antiseptic, in particular by the low side effects and broad spectrum of activity.
  • it is problematic in both substances that they require a comparatively long exposure time to develop their effect, for example in comparison to chlorhexidine, which is used primarily in dentistry as an antiseptic.
  • chlorhexidine has the disadvantage that it is potentially neurotoxic, can lead to premalignant alteration, can be mutagenic and is potentially allergenic.
  • Chlorhexidine is also not approved in some Asian countries such as Japan. The technical problem underlying the present invention can be seen to provide novel antiseptic medical preparations.
  • the technical problem underlying the present invention can also be seen in particular to provide novel antiseptic medicinal preparations for use in the oral cavity, in particular in periodontal pockets.
  • the technical problem underlying the present invention can also be seen to provide new uses of polyhexanide and / or octenidine.
  • the invention solves the underlying technical problem by providing a medical preparation according to claim 1.
  • the invention solves the underlying technical problem by providing a medical preparation containing a) an antiseptic selected from at least one quaternary ammonium compound and b) a carrier.
  • the invention solves the underlying technical problem by providing a medical preparation containing a) an antiseptic selected from the group consisting of polyhexanide, octenidine and mixtures thereof and b) a carrier.
  • the carrier is solid.
  • the carrier is not a wound dressing and no patch.
  • the carrier is preferably no wound dressing and no patch when the antiseptic is polyhexanide.
  • the medicinal preparation contains polyhexanide or octenidine.
  • the medicinal preparation contains polyhexanide.
  • the medicinal preparation contains octenidine.
  • the medicinal preparation contains polyhexanide and a solid carrier.
  • the preparation contains octenidine and a solid carrier.
  • the polyhexanide is included in the medical preparation at an application level of from 0.002% to 0.4%, more preferably from at least 0.02% to at most 0.04%.
  • the polyhexanide is contained in the medicinal preparation in an application concentration of at least 0.002, in particular of at least 0.02%.
  • the polyhexanide is contained in the medicinal preparation at an application concentration of at most 0.4%, in particular of at most 0.04%.
  • the octenidine is included in the medicinal preparation at an application level of from 0.002% to 0.4%, more preferably from at least 0.02% to at most 0.04%. In a preferred embodiment, the octenidine is contained in the medicinal preparation in an application concentration of at least 0.002, in particular of at least 0.02%. In a preferred embodiment, the octenidine is in the me- medical preparation at an application concentration of at most 0.4%, in particular of at most 0.04%.
  • the octenidine may be used in a mixture with phenoxyethanol and / or with ethanol.
  • ethanol is contained in the medicinal preparation at an application concentration of 3% to 19%, in particular of about 10%.
  • phenoxyethanol is contained in the medicinal preparation at an application concentration of 0.5% to 8%, in particular of about 2%.
  • polyhexanide or octenidine with a carrier leads to the fact that the polyhexanide or octenidine can be applied advantageously over a long period at the site to be treated, for example in the mouth area, and thus have an effect there allows.
  • the effect achieved in this way is many times better than when using said antiseptics in liquid form, for example in mouthwashes or semi-solid forms, for example as an ointment, since the antiseptics can be removed again so quickly and can not act.
  • the carrier is substantially biodegradable.
  • the carrier is impregnated in the polyhexanide and / or octenidine.
  • the carrier is impregnated in polyhexanide or octenidine.
  • the carrier is impregnated in polyhexanide.
  • the carrier is soaked in octenidine.
  • the carrier is coated with the polyhexanide and / or octenidine. In a preferred embodiment, the carrier is coated with polyhexanide or octenidine. In a preferred embodiment, the carrier is coated with polyhexanide. In an alternative embodiment, the carrier is coated with octenidine.
  • the carrier is coated with a coating.
  • the carrier is a flat carrier, for example in the form of a chip.
  • a carrier in the form of a chip can advantageously be introduced into a periodontal pocket, for example.
  • a person skilled in the art can produce or trim the carrier in the desired and suitable size.
  • the carrier is vegetable and / or plastic based and the carrier is provided with the polyhexanide and / or octenidine and a polymeric coating or coating of a natural or synthetic wax, the carrier and coating being substantially biodegradable , In a preferred embodiment, the carrier is based on polysaccharides.
  • the carrier is selected from starch, cellulose, cellulose derivatives, polyglycolides and their copolymers, polyvinylpyrrolidone and mixtures thereof.
  • the carrier and the coating are each selected so that their degradation rate is different.
  • the polymeric coating is selected from a natural wax, cellulose derivatives, polyethylene glycol, (meth) acrylic acid copolymers and / or mixtures thereof and optionally further excipients.
  • the carrier is not a patch. In a preferred embodiment, the carrier is not a wound dressing. In a preferred embodiment, the antiseptic is polyhexanide and the carrier is not a patch. In a preferred embodiment, the antiseptic is polyhexanide and the carrier is not a wound dressing.
  • the carrier is an underlay fleece.
  • the underlay fleece preferably serves for the mechanical protection of the skin in front of an artificial object lying on the skin, for example a peripheral venous catheter, for example at a puncture site or around a puncture site or during a drainage.
  • the carrier is cotton wool or a sponge.
  • a cotton wool or sponge can be easily inserted into an ear or vagina to be treated.
  • the carrier is a paper strip or a paper tip. Such a paper tip can be easily introduced into a root canal.
  • the carrier is a thread.
  • a thread can be easily inserted or inserted at wound sites.
  • the carrier is a diaper or panty liner.
  • the carrier is a dental dressing plate, dental splint or dental thermoforming foil.
  • the medicinal preparation according to the invention is used for the treatment of viral, bacterial and / or mycotic diseases.
  • the medicinal preparation according to the invention is used for the treatment of diseases by bacteria, in particular by gram negative bacteria. But it can also be treated diseases by gram positive bacteria.
  • the medicinal preparation according to the invention is used for the treatment of diseases by Agregatibacter actinomycetemcomitans.
  • the present invention also relates to the use of a medical preparation according to the invention for the treatment of inflammatory processes.
  • the medicinal preparation according to the invention is used for the treatment of inflammatory processes in the ear or in the oral cavity, in particular for the control and / or prevention of periodontitis and for the treatment of diseases of the tooth root.
  • the medicinal preparation according to the invention is used for the treatment of inflammatory processes in periodontal pockets.
  • the invention thus also preferably relates to a medical preparation according to the invention for use in the treatment of inflammatory processes in periodontal pockets.
  • the invention therefore also preferably relates to the use of the medicinal preparation according to the invention for the treatment of inflammatory processes in periodontal pockets.
  • the invention thus also preferably relates to the use of an antiseptic selected from the group consisting of polyhexanide, octenisept and mixtures thereof and a carrier for the preparation of a medicinal preparation for the treatment of inflammatory processes in periodontal pockets.
  • the invention thus also preferably relates to a medical preparation containing polyhexanide for use in accordance with the invention the treatment of inflammatory processes in periodontal pockets.
  • the invention therefore also preferably relates to the use of the medicinal preparation according to the invention containing polyhexanide for the treatment of inflammatory processes in gingival pockets.
  • the invention thus also preferably relates to the use of polyhexanide and of a carrier for the production of a medicinal preparation for the treatment of inflammatory processes in periodontal pockets.
  • the invention preferably also relates to an inventive medical preparation containing octenidine for use in the treatment of inflammatory processes in periodontal pockets.
  • the invention thus also preferably relates to the use of the medicinal preparation according to the invention containing octenidine for the treatment of inflammatory processes in gum pockets.
  • the invention also preferably relates to that of octenidine and of a carrier for the preparation of a medicinal preparation for the treatment of inflammatory processes in periodontal pockets.
  • the pharmaceutical preparation according to the invention is frosted or introduced into the periodontal pocket.
  • the site of action is thus preferred in the periodontal pocket.
  • the pharmaceutical preparation according to the invention is preferably used against anaerobic bacteria, in particular aggregatibacter actinomycetemcomitans.
  • the target of action are thus preferably anaerobic bacteria, in particular aggregatibacter actinomycetemco- mitans.
  • a pharmaceutical preparation according to the invention can be used particularly well in periodontal pockets for the treatment of inflammatory processes.
  • polyhexanide and / or octenidine preferably act on anaerobic pathogens present there and lead to a penetration and dissolution of an existing biofilm, in which the anaerobic pathogens can store in a protected manner. Therefore, a corresponding use of the carrier according to the invention is also preferred.
  • the pharmaceutical preparation according to the invention is used for the treatment of inflammations caused in a periodontal pocket by aggregatibacter actinomycetemcomitans. In a preferred embodiment, the pharmaceutical preparation according to the invention is used for combating periodontitis caused in a periodontal pocket by aggregatibacter actinomycetemcomitans.
  • Aggregatibacter actinomycetemcomitans is a Gram-negative, non-motile bacterium commonly found in the oral flora as a commensal. Aggregatibacter actinomycetemcomitans can grow under anaerobic conditions. The pathogen is typically catalase-positive and oxidase-negative. He can metabolize carbohydrates such as glucose, fructose, maltose and mannose, occasionally xylose and mannitol. Aggregatibacter actinomycetemcomitans often appears as a concomitant of aggressive periodontitis and severe gingival infections.
  • the present invention also relates to the use of polyhexanide and / or octenidine for the preparation of a medicinal preparation according to the invention for the treatment of inflammatory processes. in particular in the ear or in the oral cavity, in particular for the control and / or prevention of periodontitis and for the treatment of diseases of the tooth root or the periodontal pocket.
  • the present invention relates in particular to the use of polyhexanide and / or octenidine for the preparation of a medicinal preparation according to the invention for controlling and / or preventing periodontitis and for treating diseases of the tooth root or the periodontal pocket, wherein preferably the periodontitis and / or diseases of the tooth root or of the periodontal pocket are caused by aggregatibacter actinomycetemcomitans.
  • the present invention also relates to a method for the treatment of inflammatory processes in a tooth pocket, in which a carrier according to the invention is introduced into the tooth pocket and can then act there.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des compositions pharmaceutiques et notamment des préparations médicinales qui contiennent un excipient et un antiseptique, lequel antiseptique est choisi dans le groupe formé par le polyhexanide, l'octénidine et des mélanges de ceux-ci. L'invention concerne également différents produits contenant une telle préparation médicinale, ainsi que des applications spécifiques de cette préparation médicinale.
EP13770871.5A 2012-09-24 2013-09-24 Préparation médicinale comprenant un excipient avec du polyhexanide ou de l'octénidine Ceased EP2897617A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012019194.4A DE102012019194A1 (de) 2012-09-24 2012-09-24 Medizinisches Präparat umfassend einen Träger mit Polyhexanid oder Octenidin
PCT/EP2013/069825 WO2014044869A2 (fr) 2012-09-24 2013-09-24 Préparation médicinale comprenant un excipient avec du polyhexanide ou de l'octénidine

Publications (1)

Publication Number Publication Date
EP2897617A2 true EP2897617A2 (fr) 2015-07-29

Family

ID=49274617

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13770871.5A Ceased EP2897617A2 (fr) 2012-09-24 2013-09-24 Préparation médicinale comprenant un excipient avec du polyhexanide ou de l'octénidine

Country Status (3)

Country Link
EP (1) EP2897617A2 (fr)
DE (1) DE102012019194A1 (fr)
WO (1) WO2014044869A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE202014101882U1 (de) 2014-04-22 2014-05-02 Armin Armani Orales Abgabesystem
US10786448B2 (en) 2018-01-18 2020-09-29 Christian Arnold Chewing gum composition comprising polyhexanide
EP3969486B1 (fr) 2019-05-14 2023-07-12 Coloplast A/S Compositions élastomères de silicone comprenant du glycérol, de la cyclodextrine et de l'octénidine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120070480A1 (en) * 2010-09-17 2012-03-22 3M Innovative Properties Company Antimicrobial disposable absorbent articles

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Publication number Priority date Publication date Assignee Title
FR2644060B1 (fr) 1989-03-10 1993-10-29 Anben Ste Civile Medicament, notamment pour le traitement de maladies a virus du type herpes cutane, oculaire et genital
DE10162058A1 (de) * 2001-12-17 2003-07-24 Cospharcon Gmbh Gefäßaktive, juckreiz- und entzündungslindernde Zubereitung zur Minimierung der unangenehmen Begleiterscheinungen hämorrhoidaler Affekte und Ekzeme im Analbereich sowie als unterstützende Maßnahme zur Intertrigo- und Dekubitus-Prophylaxe bei entsprechend disponierten Personen.
DE202006016821U1 (de) 2005-11-02 2007-03-29 Riesinger, Birgit Absorbierender Körper zur Anbringung an menschliche oder tierische Körperoberflächen
WO2010031096A1 (fr) 2008-09-18 2010-03-25 Croma-Pharma Gesellschaft M.B.H. Composition à action antimicrobienne et antivirale
DE102010013075A1 (de) 2010-03-26 2011-09-29 B. Braun Melsungen Ag Antimikrobielle Wundauflage
DE102010022367A1 (de) 2010-04-20 2011-10-20 Klosterfrau Berlin Gmbh Gel, insbesondere Gleitgel, und seine Verwendung

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120070480A1 (en) * 2010-09-17 2012-03-22 3M Innovative Properties Company Antimicrobial disposable absorbent articles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANJA G. JUNG ET AL: "Acrodermatitis enteropathica: an uncommon differential diagnosis in childhood - first description of a new sequence variant", JDDG. JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, vol. 9, no. 12, 15 July 2011 (2011-07-15), DE, pages 999 - 1002, XP055322366, ISSN: 1610-0379, DOI: 10.1111/j.1610-0387.2011.07742.x *
See also references of WO2014044869A2 *

Also Published As

Publication number Publication date
WO2014044869A3 (fr) 2014-06-12
WO2014044869A2 (fr) 2014-03-27
DE102012019194A1 (de) 2014-04-17

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