EP2887930A4 - ANXIOLYTIC COMPOSITION, FORMULATION AND METHOD OF USE - Google Patents

ANXIOLYTIC COMPOSITION, FORMULATION AND METHOD OF USE

Info

Publication number
EP2887930A4
EP2887930A4 EP13831683.1A EP13831683A EP2887930A4 EP 2887930 A4 EP2887930 A4 EP 2887930A4 EP 13831683 A EP13831683 A EP 13831683A EP 2887930 A4 EP2887930 A4 EP 2887930A4
Authority
EP
European Patent Office
Prior art keywords
formulation
anxiolytic composition
anxiolytic
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP13831683.1A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2887930A1 (en
Inventor
Stuart L Weg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to EP21156344.0A priority Critical patent/EP3878442A1/en
Publication of EP2887930A1 publication Critical patent/EP2887930A1/en
Publication of EP2887930A4 publication Critical patent/EP2887930A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP13831683.1A 2012-08-23 2013-08-23 ANXIOLYTIC COMPOSITION, FORMULATION AND METHOD OF USE Ceased EP2887930A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP21156344.0A EP3878442A1 (en) 2012-08-23 2013-08-23 Anxiolytic composition comprising ketamine, formulation and method of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261692380P 2012-08-23 2012-08-23
PCT/US2013/056424 WO2014031975A1 (en) 2012-08-23 2013-08-23 Anxiolytic composition, formulation and method of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP21156344.0A Division EP3878442A1 (en) 2012-08-23 2013-08-23 Anxiolytic composition comprising ketamine, formulation and method of use

Publications (2)

Publication Number Publication Date
EP2887930A1 EP2887930A1 (en) 2015-07-01
EP2887930A4 true EP2887930A4 (en) 2016-03-23

Family

ID=50148531

Family Applications (2)

Application Number Title Priority Date Filing Date
EP13831683.1A Ceased EP2887930A4 (en) 2012-08-23 2013-08-23 ANXIOLYTIC COMPOSITION, FORMULATION AND METHOD OF USE
EP21156344.0A Pending EP3878442A1 (en) 2012-08-23 2013-08-23 Anxiolytic composition comprising ketamine, formulation and method of use

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP21156344.0A Pending EP3878442A1 (en) 2012-08-23 2013-08-23 Anxiolytic composition comprising ketamine, formulation and method of use

Country Status (11)

Country Link
US (4) US20140057988A1 (cg-RX-API-DMAC7.html)
EP (2) EP2887930A4 (cg-RX-API-DMAC7.html)
JP (2) JP6722453B2 (cg-RX-API-DMAC7.html)
KR (1) KR20150096370A (cg-RX-API-DMAC7.html)
CN (1) CN104902883A (cg-RX-API-DMAC7.html)
AU (1) AU2013305580A1 (cg-RX-API-DMAC7.html)
BR (1) BR112015003796A2 (cg-RX-API-DMAC7.html)
IL (1) IL237340A0 (cg-RX-API-DMAC7.html)
MX (1) MX2015002378A (cg-RX-API-DMAC7.html)
SG (1) SG11201501292UA (cg-RX-API-DMAC7.html)
WO (1) WO2014031975A1 (cg-RX-API-DMAC7.html)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111643449A (zh) 2013-03-15 2020-09-11 詹森药业有限公司 S-盐酸氯胺酮的药物组合物
HUE045982T2 (hu) * 2013-03-15 2020-01-28 Janssen Pharmaceutica Nv S-Ketamin-hidroklorid gyógyászati kompozíció
JP6462663B2 (ja) 2013-04-12 2019-01-30 アイカーン スクール オブ メディシン アット マウント シナイ 心的外傷後ストレス障害を処置するための方法
HRP20211629T1 (hr) 2013-09-13 2022-02-04 National University Corporation Chiba University Primjena r-ketamina i njegove soli kao lijekova
US10098854B2 (en) 2014-08-13 2018-10-16 Janssen Pharmaceutica Nv Method for the treatment of depression
JP6757537B2 (ja) * 2014-08-29 2020-09-23 公益財団法人ヒューマンサイエンス振興財団 神経疾患モデル動物の製造方法及び神経疾患モデル動物
MA40620A (fr) 2014-09-15 2016-03-24 Janssen Pharmaceutica Nv Régimes posologiques spécifiques au génotype val66met (snp rs6265) et méthodes pour le traitement de la dépression
EP3085366A1 (en) * 2015-04-22 2016-10-26 Institut du Cerveau et de la Moelle Epiniere-ICM Nmda antagonists for the treatment of mental disorders with occurrence of aggressive and/or impulsive behavior
US20160332962A1 (en) 2015-05-13 2016-11-17 Janssen Pharmaceutica Nv (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine
EA201792571A1 (ru) * 2015-05-22 2018-06-29 Вистаджен Терапьютикс, Инк. Терапевтическое применение l-4-хлорокинуренина
JP6845162B2 (ja) 2015-06-27 2021-03-17 シェノックス・ファーマシューティカルズ・エルエルシー ケタミン経皮送達システム
CN105249531A (zh) * 2015-08-06 2016-01-20 云南中烟工业有限责任公司 一种金丝楠木提取物的制备方法及其应用
US11173153B2 (en) * 2015-09-08 2021-11-16 The Children's Hospital Of Philadelphia Methods of diagnosing and treating anxiety disorder
WO2017087691A1 (en) * 2015-11-17 2017-05-26 The Trustees Of Columbia University In The City Of New York Pharmacological prophylactics against stress-induced affective disorders and their associated symptoms
US20200009081A1 (en) 2017-09-13 2020-01-09 Janssen Pharmaceutica N.V. Delivery Of Esketamine For The Treatment Of Depression
US11491120B2 (en) 2017-11-09 2022-11-08 The Trustees Of Columbia University In The City Of New York Pharmacological prophylactics against stress-induced affective disorders in females
WO2019094596A1 (en) 2017-11-09 2019-05-16 The Trustees Of Columbia University In The City Of New York Biomarkers for efficacy of prophylactic treatments against stress-induced affective disorders
FR3075038B1 (fr) * 2017-12-15 2020-03-06 Melchior Material And Life Science France Utilisation de la fluoroethylnormemantine pour la prevention de l'apparition et le traitement de l'anxiete
KR20240011237A (ko) 2017-12-22 2024-01-25 얀센 파마슈티카 엔브이 우울증 치료를 위한 에스케타민
ES2907692T3 (es) 2017-12-29 2022-04-26 Celon Pharma Sa Composición de ketamina de polvo seco para su administración por vía pulmonar en la depresión resistente al tratamiento
CN111936127A (zh) 2018-02-15 2020-11-13 国立大学法人千叶大学 炎症性疾病或骨病的预防或治疗剂及医药组合物
CN112533595A (zh) 2018-05-04 2021-03-19 感知神经科学公司 治疗物质滥用的方法
WO2020041329A1 (en) * 2018-08-20 2020-02-27 Yale University Combination therapy for treating or preventing depression or other mood diseases
US12115601B2 (en) 2019-02-22 2024-10-15 Harima Chemicals, Incorporated Method of applying solid brazing material, method of producing coated workpiece, application apparatus, and roll-shaped solid brazing material
EP3934632A4 (en) 2019-03-05 2022-11-23 Janssen Pharmaceuticals, Inc. Esketamine for the treatment of depression
EP3968977A4 (en) * 2019-05-15 2023-01-11 The Trustees of Columbia University in the City of New York COMPOSITIONS AND METHODS AGAINST AFFECTIVE DISORDERS INDUCED BY STRESS AND THEIR ASSOCIATED SYMPTOMS
WO2020240279A1 (en) * 2019-05-31 2020-12-03 Lionheart Pharmaceuticals Aps Intranasal administration of ketamine to cluster headache patients
IL294485A (en) 2020-01-22 2022-09-01 Seelos Therapeutics Inc Reduction of side effects of nmda antagonists

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000056301A2 (en) * 1999-03-19 2000-09-28 Synchroneuron, Llc Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders
EP1103256A1 (de) * 1999-11-26 2001-05-30 Claudius Dr. med. Böck Verwendung von Ketamin zur Behandlung von neuroendokriner Immundysfunktion und algogenem Psychosyndrom

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543434A (en) * 1994-02-25 1996-08-06 Weg; Stuart L. Nasal administration of ketamine to manage pain
US5679714A (en) * 1995-06-07 1997-10-21 Weg; Stuart L. Administration of ketamine for detoxification and treatment of tobacco addiction
US6248789B1 (en) 1996-08-29 2001-06-19 Stuart L. Weg Administration of ketamine to manage pain and to reduce drug dependency
CN101466364A (zh) * 2006-03-22 2009-06-24 纽约大学西奈山医学院 鼻内施用氯胺酮治疗抑郁症
EP2139848A1 (en) * 2007-04-26 2010-01-06 Auspex Pharmaceuticals, Inc. Deuterium labelled ketamine
US20110038807A1 (en) * 2009-08-14 2011-02-17 Demitri Papolos Compositions and methods for treating bipolar disorder

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000056301A2 (en) * 1999-03-19 2000-09-28 Synchroneuron, Llc Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders
EP1103256A1 (de) * 1999-11-26 2001-05-30 Claudius Dr. med. Böck Verwendung von Ketamin zur Behandlung von neuroendokriner Immundysfunktion und algogenem Psychosyndrom

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
A ODA ET AL: "Patient anxiety scores after low-dose ketamine or fentanyl for epidural catheter placement", CANADIAN JOURNAL OF ANAESTHESIA / JOURNAL CANADIEN D'ANESTHESIE, vol. 47, no. 9, September 2000 (2000-09-01), CA, pages 910 - 913, XP055245914, ISSN: 0832-610X *
B KRYSHTALSKYJ ET AL: "Use of low-dose ketamine hydrochloride in outpatient oral surgery", ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, vol. 69, no. 4, April 1990 (1990-04-01), US, pages 413 - 419, XP055245874, ISSN: 0030-4220 *
FEDER ADRIANA ET AL: "Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder A Randomized Clinical Trial", JAMA PSYCHIATRY,, vol. 71, no. 6, 1 June 2014 (2014-06-01), pages 681 - 688, XP009186290 *
HOSSEINI JAHROMI S A ET AL: "Comparison of the effects of intranasal midazolam versus different doses of intranasal ketamine on reducing preoperative pediatric anxiety: a prospective randomized clinical trial", JOURNAL OF ANESTHESIA, SPRINGER-VERLAG, TO, vol. 26, no. 6, 12 June 2012 (2012-06-12), pages 878 - 882, XP035153692, ISSN: 1438-8359, DOI: 10.1007/S00540-012-1422-6 *
LAURA MUSAZZI ET AL: "What Acute Stress Protocols Can Tell Us About PTSD and Stress-Related Neuropsychiatric Disorders", FRONTIERS IN PHARMACOLOGY, vol. 9, 12 July 2018 (2018-07-12), XP055647568, DOI: 10.3389/fphar.2018.00758 *
LOO C C ET AL: "Sedation for the conduct of lumbar epidural anaesthesia: A study using subanaesthetic dose of ketamine in combination with midazolam", ANNALS ACADEMY OF MEDICINE SINGAPORE, vol. 26, no. 2, 1997, pages 200 - 204, XP009188255, ISSN: 0304-4602 *
MCGHEE LAURA L ET AL: "The correlation between ketamine and posttraumatic stress disorder in burned service members", JOURNAL OF TRAUMA, WILLIAMS & WILKINS, US, vol. 64, no. 2, Suppl. S, 1 February 2008 (2008-02-01), pages S195 - S199, XP009192662, ISSN: 0022-5282, DOI: 10.1097/TA.0B013E318160BA1D *
See also references of WO2014031975A1 *

Also Published As

Publication number Publication date
BR112015003796A2 (pt) 2017-07-04
WO2014031975A1 (en) 2014-02-27
US20250255834A1 (en) 2025-08-14
MX2015002378A (es) 2015-09-25
US20220160655A1 (en) 2022-05-26
SG11201501292UA (en) 2015-05-28
CN104902883A (zh) 2015-09-09
US20180235906A1 (en) 2018-08-23
JP6722453B2 (ja) 2020-07-15
EP3878442A1 (en) 2021-09-15
JP2018162302A (ja) 2018-10-18
US20140057988A1 (en) 2014-02-27
KR20150096370A (ko) 2015-08-24
IL237340A0 (en) 2015-04-30
AU2013305580A1 (en) 2015-04-09
JP6771512B2 (ja) 2020-10-21
EP2887930A1 (en) 2015-07-01
JP2016501828A (ja) 2016-01-21

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