EP2859112A4 - Verfahren zur herstellung von oligosacchariden und oligosaccharidglykosiden durch fermentation - Google Patents

Verfahren zur herstellung von oligosacchariden und oligosaccharidglykosiden durch fermentation

Info

Publication number
EP2859112A4
EP2859112A4 EP13800288.6A EP13800288A EP2859112A4 EP 2859112 A4 EP2859112 A4 EP 2859112A4 EP 13800288 A EP13800288 A EP 13800288A EP 2859112 A4 EP2859112 A4 EP 2859112A4
Authority
EP
European Patent Office
Prior art keywords
fermentation
producing oligosaccharides
oligosaccharide glycosides
glycosides
oligosaccharide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13800288.6A
Other languages
English (en)
French (fr)
Other versions
EP2859112A1 (de
Inventor
Pauline Peltier-Pain
Gyula Dekany
Remy Dureau
Christian Risinger
Markus Hederos
Elise Champion
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glycom AS
Original Assignee
Glycom AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycom AS filed Critical Glycom AS
Publication of EP2859112A1 publication Critical patent/EP2859112A1/de
Publication of EP2859112A4 publication Critical patent/EP2859112A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/64—Preparation of S-glycosides, e.g. lincomycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EP13800288.6A 2012-06-08 2013-06-07 Verfahren zur herstellung von oligosacchariden und oligosaccharidglykosiden durch fermentation Withdrawn EP2859112A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA201270313 2012-06-08
DKPA201200395 2012-06-11
DKPA201270332 2012-06-15
DKPA201270656 2012-10-25
PCT/DK2013/050182 WO2013182206A1 (en) 2012-06-08 2013-06-07 Method for producing oligosaccharides and oligosaccharide glycosides by fermentation

Publications (2)

Publication Number Publication Date
EP2859112A1 EP2859112A1 (de) 2015-04-15
EP2859112A4 true EP2859112A4 (de) 2015-10-28

Family

ID=49711430

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13800288.6A Withdrawn EP2859112A4 (de) 2012-06-08 2013-06-07 Verfahren zur herstellung von oligosacchariden und oligosaccharidglykosiden durch fermentation

Country Status (2)

Country Link
EP (1) EP2859112A4 (de)
WO (1) WO2013182206A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3041946B1 (de) 2013-09-06 2021-05-26 Glycom A/S Fermentative herstellung von oligosacchariden
EP2896628B1 (de) 2014-01-20 2018-09-19 Jennewein Biotechnologie GmbH Verfahren zur effizienten Reinigung von neutralen humanen Milch-Oligosacchariden (HMOs) aus mikrobieller Fermentation
CN103820513A (zh) * 2014-02-27 2014-05-28 中国科学院微生物研究所 合成唾液酸化寡糖及类似物的方法
EP3461890A1 (de) * 2014-03-31 2019-04-03 Jennewein Biotechnologie GmbH Vollständige fermentation von oligosacchariden
US11926858B2 (en) 2014-06-27 2024-03-12 Glycom A/S Oligosaccharide production
WO2015197082A1 (en) 2014-06-27 2015-12-30 Glycom A/S Oligosaccharide production
BR112017000596A2 (pt) 2014-07-14 2018-01-23 Basf Se micro-organismo geneticamente modificado, uso de um micro-organismo geneticamente modificado, e, método para preparar lacto-n-tetraose ou lacto-n-neotetraose ou um derivado fusosilado de lacto-n-tetraose ou lacto-n-neotetraose
WO2017101958A1 (en) 2015-12-18 2017-06-22 Glycom A/S Fermentative production of oligosaccharides
EP3426670A4 (de) 2016-03-07 2019-11-13 Glycom A/S Abtrennung von oligosacchariden aus einer fermentationsbrühe
EP3445770A4 (de) 2016-04-19 2020-03-18 Glycom A/S Trennung von oligosacchariden aus fermentationsbrühe
EP3456836A1 (de) 2017-09-13 2019-03-20 Glycom A/S Abtrennung von sialylierten oligosacchariden aus der fermentationsbrühe
JP7304863B2 (ja) 2017-12-29 2023-07-07 グリコミメティクス， インコーポレイテッド Ｅ－セレクチンおよびガレクチン－３のヘテロ二機能性阻害剤
KR20210110645A (ko) 2018-12-27 2021-09-08 글리코미메틱스, 인크. 갈렉틴-3 억제 c-글리코사이드
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
MX2022002949A (es) 2019-09-24 2022-04-06 Prolacta Bioscience Inc Composiciones y metodos para el tratamiento de enfermedades inflamatorias e inmunes.
US20230212628A1 (en) 2019-12-18 2023-07-06 Inbiose N.V. Production of Sialylated Oligosaccharide in Host Cells
KR20220116504A (ko) 2019-12-19 2022-08-23 바스프 에스이 정밀 화학물의 제조에서 공시 수율, 탄소-전환-효율 및 탄소 기질 적응성의 증가
CN115803443A (zh) 2020-07-13 2023-03-14 格礼卡姆股份公司 寡糖的制造
KR20230088680A (ko) 2020-08-14 2023-06-20 프롤랙타 바이오사이언스, 인코포레이티드 박테리아 요법에 사용하기 위한 인간 모유 올리고당 조성물
EP4277634A1 (de) 2021-01-12 2023-11-22 Prolacta Bioscience, Inc. Synbiotische behandlungsschemata
JP2024516207A (ja) 2021-05-17 2024-04-12 ディーエスエム アイピー アセッツ ビー．ブイ． インベルターゼ／スクロースヒドロラーゼを発現する微生物株

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2796082B1 (fr) * 1999-07-07 2003-06-27 Centre Nat Rech Scient Procede de production d'oligosaccharides
WO2008002230A1 (en) * 2006-03-04 2008-01-03 Nilsson Kurt G I Production of glycoside oligosaccharides
ATE498629T1 (de) 2006-03-13 2011-03-15 Glycom Aps Neue lactosaminderivate
EP1911850A1 (de) 2006-10-09 2008-04-16 Centre National De La Recherche Scientifique (Cnrs) Verfahren zur Herstellung von 6-thio-sialierten Glykoproteinen und Glycokonjugaten
CN105330705A (zh) 2010-02-19 2016-02-17 格礼卡姆股份公司 用于制备含n-乙酰乳糖胺的四糖乳糖-n-新四糖(lnnt)的方法
KR20120138772A (ko) 2010-02-19 2012-12-26 글리콤 에이/에스 ６’?ｏ?시알릴락토오스 및 중간체의 제조
RU2013106896A (ru) 2010-07-16 2014-08-27 Глюком А/С Синтез новых производных сиалоолигосахаридов
EP2678347A4 (de) 2011-02-21 2014-10-08 Glycom As Katalytische hydrogenolyse einer zusammensetzung aus einer mischung von oligosaccharidvorläufern und anwendungen davon
US20140228554A1 (en) 2011-03-18 2014-08-14 Glycom A/S Synthesis of new fucose-containing carbohydrate derivatives
CN103703012A (zh) 2011-05-13 2014-04-02 格礼卡姆股份公司 乳糖-n-四糖的制造

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO2013182206A1 *

Also Published As

Publication number Publication date
EP2859112A1 (de) 2015-04-15
WO2013182206A1 (en) 2013-12-12

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