EP2855658A4 - Integrated system for real-time monitoring of microfluidic reactions - Google Patents

Integrated system for real-time monitoring of microfluidic reactions

Info

Publication number
EP2855658A4
EP2855658A4 EP13797711.2A EP13797711A EP2855658A4 EP 2855658 A4 EP2855658 A4 EP 2855658A4 EP 13797711 A EP13797711 A EP 13797711A EP 2855658 A4 EP2855658 A4 EP 2855658A4
Authority
EP
European Patent Office
Prior art keywords
real
time monitoring
integrated system
microfluidic reactions
microfluidic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP13797711.2A
Other languages
German (de)
French (fr)
Other versions
EP2855658A1 (en
Inventor
Jiang Zhu
Hongju Guo
Danyang Mei
Xiumei Song
Dong Wang
Jing Cheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tsinghua University
CapitalBio Technology Co Ltd
Original Assignee
Tsinghua University
CapitalBio Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tsinghua University, CapitalBio Corp filed Critical Tsinghua University
Publication of EP2855658A1 publication Critical patent/EP2855658A1/en
Publication of EP2855658A4 publication Critical patent/EP2855658A4/en
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP13797711.2A 2012-05-31 2013-05-31 Integrated system for real-time monitoring of microfluidic reactions Pending EP2855658A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201210177086.6A CN102719357B (en) 2012-05-31 2012-05-31 Hybridization system for real-time monitoring parsing process of micro array chip
PCT/CN2013/000647 WO2013177953A1 (en) 2012-05-31 2013-05-31 Integrated system for real-time monitoring of microfluidic reactions

Publications (2)

Publication Number Publication Date
EP2855658A1 EP2855658A1 (en) 2015-04-08
EP2855658A4 true EP2855658A4 (en) 2016-02-24

Family

ID=46945234

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13797711.2A Pending EP2855658A4 (en) 2012-05-31 2013-05-31 Integrated system for real-time monitoring of microfluidic reactions

Country Status (3)

Country Link
EP (1) EP2855658A4 (en)
CN (1) CN102719357B (en)
WO (1) WO2013177953A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102719357B (en) * 2012-05-31 2014-07-09 博奥生物集团有限公司 Hybridization system for real-time monitoring parsing process of micro array chip
CN104226384B (en) * 2013-06-06 2015-12-02 博奥生物集团有限公司 Liquid-discharging means of bottle
TWI513508B (en) * 2013-09-06 2015-12-21 Ind Tech Res Inst Apparatus for microfluid detection
US9341639B2 (en) 2013-07-26 2016-05-17 Industrial Technology Research Institute Apparatus for microfluid detection
CN104437702B (en) * 2014-11-21 2016-04-06 陈永欣 Multichannel filter
CN105733936B (en) * 2014-12-12 2017-11-17 深圳华大基因研究院 Gene sequencer
CN105521841B (en) * 2016-02-04 2017-06-23 龙岩市九健生物芯片有限公司 A kind of biochip hybridizing box
US11513076B2 (en) 2016-06-15 2022-11-29 Ludwig-Maximilians-Universität München Single molecule detection or quantification using DNA nanotechnology
CN208224274U (en) * 2018-04-27 2018-12-11 广州万孚生物技术股份有限公司 A kind of micro-fluidic chip and the analysis instrument with the micro-fluidic chip
CN110904274A (en) * 2019-12-13 2020-03-24 福建工程学院 Flow control type HPV genotyping chip detection method
JP7420950B2 (en) * 2019-12-17 2024-01-23 アプライド マテリアルズ インコーポレイテッド Systems and methods for acquiring and processing multiplex fluorescence in situ hybridization images
CN111397660B (en) * 2020-04-03 2022-03-15 天津大学 Multifunctional photonic chip detection system
CN111504941B (en) * 2020-05-14 2021-01-01 中国人民解放军陆军军医大学第一附属医院 Terahertz attenuated total reflection technology platform for unmarked evaluation of response characteristics of responsive hydrogel
CN112175820B (en) * 2020-10-10 2022-09-02 上海世艾生物科技有限公司 Nucleic acid extraction and pcr integrated device and working method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7314718B1 (en) * 2001-04-03 2008-01-01 Bioarray Solutions Ltd. Method and apparatus for maintaining multiple planar fluid flows
US20110111968A1 (en) * 2008-06-25 2011-05-12 Real-Time Genomics, Llc Method and Apparatus for Melting Curve Analysis of Nucleic Acids in Microarray Format
US20140011707A1 (en) * 2011-03-22 2014-01-09 Tsinghua University Biological chip hybridization system

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CN1330154A (en) * 2000-06-27 2002-01-09 南京益来基因医学有限公司 Cell microarray chip and its preparing process
CN2485313Y (en) * 2001-06-21 2002-04-10 张家洵 Multifunctional molecular hybridizationer
JP3691837B2 (en) * 2002-08-16 2005-09-07 株式会社林創研 Biochip analyzer
CN1289904C (en) * 2003-08-01 2006-12-13 博奥生物有限公司 Micro array reaction unit and its use
ES2284087T3 (en) * 2005-01-18 2007-11-01 F. Hoffmann-La Roche Ag GENERATION OF FLUORESCENCE SIGNAL IMAGES BY TELECENTRIC EXCITATION AND IMAGE GENERATION OPTICS.
CN100417931C (en) * 2005-04-06 2008-09-10 博奥生物有限公司 Microarray chip detection system
WO2006128322A1 (en) * 2005-06-02 2006-12-07 Capitalbio Corporation High speed scanning platform for microarray scanner
CN101203744B (en) * 2005-06-02 2011-06-29 博奥生物有限公司 Laser micro array chip scanner
CN101203790A (en) * 2005-06-03 2008-06-18 博奥生物有限公司 Micro array chip laser scanner optical system
US7715001B2 (en) * 2006-02-13 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
EP2023127B1 (en) * 2006-05-31 2017-12-20 Olympus Corporation Biological specimen imaging method and biological specimen imaging apparatus
EP2017354A1 (en) * 2007-07-20 2009-01-21 Eppendorf Ag Detection and/or quantification of target molecules on a solid support
CN100535644C (en) * 2007-09-21 2009-09-02 博奥生物有限公司 Micro-nano system fluid chip detection system and detection method
CN102010817B (en) * 2010-08-06 2013-05-22 博奥生物有限公司 Chip automatic loading device of microarray chip scanner
CN102206573B (en) * 2011-03-22 2014-12-31 博奥生物有限公司 Automatic sample introduction device for microarray chip and automatic sample introduction hybridization microarray chip
CN102719357B (en) * 2012-05-31 2014-07-09 博奥生物集团有限公司 Hybridization system for real-time monitoring parsing process of micro array chip

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7314718B1 (en) * 2001-04-03 2008-01-01 Bioarray Solutions Ltd. Method and apparatus for maintaining multiple planar fluid flows
US20110111968A1 (en) * 2008-06-25 2011-05-12 Real-Time Genomics, Llc Method and Apparatus for Melting Curve Analysis of Nucleic Acids in Microarray Format
US20140011707A1 (en) * 2011-03-22 2014-01-09 Tsinghua University Biological chip hybridization system

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MARTIN JENSEN SØE ET AL: "HistoFlex-a microfluidic device providing uniform flow conditions enabling highly sensitive, reproducible and quantitative in situ hybridizations", LAB ON A CHIP, vol. 11, no. 22, 1 January 2011 (2011-01-01), GB, pages 3896, XP055238751, ISSN: 1473-0197, DOI: 10.1039/c1lc20748b *
See also references of WO2013177953A1 *
TYRRELL E ET AL: "Development of a micro-fluidic manifold for copper monitoring utilising chemiluminescence detection", LAB ON A CHIP, ROYAL SOCIETY OF CHEMISTRY - CAMBRIDGE, GB, vol. 4, no. 4, 1 August 2004 (2004-08-01), pages 384 - 390, XP002584852, ISSN: 1473-0197, [retrieved on 20040426], DOI: 10.1039/B400805G *

Also Published As

Publication number Publication date
WO2013177953A1 (en) 2013-12-05
CN102719357A (en) 2012-10-10
EP2855658A1 (en) 2015-04-08
CN102719357B (en) 2014-07-09

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