Classifications

• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
  • A01N37/12—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group, wherein Cn means a carbon skeleton not containing a ring; Thio analogues thereof
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
  • A01N65/08—Magnoliopsida [dicotyledons]
  • A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/13—Amines
  • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/695—Silicon compounds
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
  • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
  • A61K35/04—Tars; Bitumens; Mineral oils; Ammonium bituminosulfonate
  • A61K35/06—Mineral oils, e.g. paraffinic oils or aromatic oils based on aromatic hydrocarbons
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
  • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Definitions

• the present invention refers to the general technical field of products for topical use, used in particular on the skin and/or scalp, and which can have, for instance, a solid, fluid, pasty or liquid, semiliquid or semi-pasty, gel, powder or foam form.
• the present invention also concerns a manufacturing process of a composition for the treatment of human or animal pediculosis including at least one active principle having filmogenic properties and designed to cover, at least partly, at least one parasite responsible for said pediculosis, to prevent the latter from breathing.
• the present invention also refers to a lotion for the treatment of pediculosis in humans or animals.
• the present invention also concerns a system for the treatment of human or animal pediculosis.
• Pediculus humanus capitis also referred to as the "head louse” lives only on the scalp of man where it is nourished and on the hair on which it lays eggs whereas Pedicullus humanus corporis also referred to as the “body louse” is fed from the remainder of the body and also lives in the folds of clothing that is not properly washed or unwashed.
• a female lives approximately 1 month during which it lays approximately 200 to 300 nits.
• the louse nourishes itself between 2 and 3 times per day, sucking in blood through its mandibles and injecting anti-coagulating saliva. It is incapable of fasting for more than 2 days, for instance on unworn clothing or unoccupied bedding.
• a child infected by untreated lice is sufficient to contaminate one or several other children. This makes it particularly difficult to get rid of these parasites globally. Scratching one's head, especially for a child, is often considered as the first clinical sign of lice infestation. The sores are caused by the movements of insects between the hair and especially to their repeated bites, in the course of which they inject an irritating saliva. The dejections of the lice are also responsible for irritation or allergic reactions. Pediculosis can sometimes generate social and psychological problems with tiredness and irritability due to difficult sleep.
• malathion forming part of the organophphorates family used particularly in the definition of combat gases during World War II.
• These molecules irreversible anticholinesterasic derivatives, inhibit the synaptic conduction of the nervous system of the parasites, and are pediculicidal and partially ovacidal.
• two applications are mandatory, applied at an interval of one week, partly because of the inefficiency of the product on young nits (1 to 3 days after laying) which do not yet have a developed nervous system.
• malathion which is generally used in a form having a high alcohol concentration representing a risk of scalp irritation or even burns, with an odor that may be unpleasant to certain patients, sometimes causing real problems of keeping to the treatment.
• malathion under certain conditions could be a mutagenic, carcinogenic agent and could even be associated with several cases of infantile leukemia.
• treatment based on pyrethrin and pyrethroids which are natural or synthetic molecules are also employed.
• Treatment based on pyrethrins also requires two applications at an interval of one week, because the product is ineffective on young nits (1 to 3 days after laying).
• the specific objects of this invention aim at remedying the various drawbacks listed above and proposing a new composition for the treatment of pediculosis, efficient both on the parasites and their eggs.
• Another object of the invention referred to is to propose a new composition for treating pediculosis which is efficient in a single application and which avoids any risk of contagion by the subject during treatment.
• Another object of the invention is to propose a new composition for treating pediculosis offering a new method of dealing with communities of children (schools, vacation camps, etc.) in order to treat an entire collective group simultaneously.
• Another object of the invention is to propose a new composition for the treatment of pediculosis, avoiding recourse to the neurotoxic insecticides.
• Another object of the invention is to propose a new composition for the treatment of pediculosis offering a real advantage in terms of pediculicidal and ovacidal efficiency but also in terms of its moisturizing and soothing capability for the scalp.
• Another object of the invention is to propose a new composition for the treatment of pediculosis which is efficient, agreeable and easy to use by the greatest number of people.
• Another object of the invention is to propose a new composition for the treatment of pediculosis which avoids the irritation of parasite bites and repeated scratching.
• Another object of the invention is to propose a new process for the manufacturing of a composition for the treatment of pediculosis including specific and controlled steps to obtain a composition which is efficient on the parasites and on their eggs.
• Another object of the invention is to propose a new system for the treatment of pediculosis which is efficient in a single application and which includes fast and easily implemented steps at the individual or collective level.
• Another object of the invention is to pose a new use of at least one first active principle having filmogenic properties in a composition to treat pediculosis which is efficient both on the parasites and their eggs.
• Another object of the invention is to propose a new process of treatment for pediculosis which is efficient both on the parasites and their eggs.
• Another object of the invention is to propose a new process of treating pediculosis which is efficient in a single application, including simple steps that are easily implemented by any user.
• the objects assigned to this invention are also achieved by means of a manufacturing process of a composition for the treatment of human or animal pediculosis including at least one first active principle having filmogenic properties and designed to cover, at least in part, at least one parasite responsible for said the pediculosis in order to prevent it from breathing, said manufacturing process being characterized in that it includes a stage of encapsulation of said at least first active principle in at least one globule whose size is designed to allow the penetration of said globule into the breathing orifices of said at least one parasite and its eggs.
• a lotion for the treatment of pediculosis in man or animal including a composition as mentioned above.
• a system for the treatment of pediculosis in man or animal comprising: - a composition conforming to the above,
• the objects assigned to this invention are finally achieved by means of a process for the treatment of pediculosis in man, in the course of which use is made of a composition including at least one first active principle having filmogenic properties and designed to cover, at least partly, at least one parasite responsible for said pediculosis to prevent it from breathing, said process being characterized in that it includes a step of penetration of said at least first active principle, which is encapsulated in at least one globule, into the breathing orifices of said at least one parasite and its eggs, size of said globule being designed to allow said penetration into said breathing orifices of said at least one parasite and its eggs.
• This invention concerns a composition for the treatment of human or animal pediculosis and in particular the treatment of ectoparasites of man, more especially lice and nits.
• it is in the form of a fluid designed for application to the human and/or animal body.
• the composition of the invention therefore advantageously takes on a liquid or semiliquid form and has a mechanical pediculicidal and ovacidal action. It is easy to apply and designed on the one hand to act against lice, and also against nits.
• this composition is used as a single application dose without recourse to the use of a neurotoxic insecticide like those normally used in the fight against pediculosis (permethrin, malathion, etc.) Indeed, it is advantageously designed for monodose pediculicidal and ovacidal treatments, in particular for the treatment of lice on man, by a single application to the surface of the scalp and hair of man.
• a neurotoxic insecticide like those normally used in the fight against pediculosis (permethrin, malathion, etc.
• composition consists of a conventional louse lotion and allows the total eradication of lice and nits from man's hair.
• the composition includes at least one first active principle having filmogenic properties and designed to cover, at least partly, at least one parasite responsible for said pediculosis, to prevent said parasite from breathing.
• Said at least first active principle is encapsulated in at least one globule whose size is designed to allow said globule to penetrate into the breathing orifices of said at least one parasite and its eggs.
• the advantage of the composition is its efficiency as a single application using globules calibrated according to the size and anatomy of the breathing systems of the parasite in its various stages of development. These globules have the property of penetrating through the spiracles, the breathing orifices and/or articulations of the parasites, of protecting and transporting the first active principle through the respiratory orifices of lice and nits.
• the first active principle acts by creating a hermetically sealed film once dry, preventing gas exchanges and therefore breathing.
• the first active principle is transported and distributed through the breathing system of the parasite by means of protective globules.
• each globule presents substantially a size which is smaller than the size of the breathing orifices of the parasite and its eggs, preferably included approximately between 1 and 10 ⁇ , preferably included approximately between 5 and 9 ⁇ .
• these globules are more or less identical to each other and are calibrated in size.
• the globule includes at least one more or less water-dispersible wall enclosing said first active principle, which wall is designed to evaporate, at least partially, to allow said first active principle first to come out, in a more or less fluid form, of the inside of the parasite through its pores, and also to solidify as a film around said the parasite and its eggs, to prevent the latter from breathing and cause their death.
• the wall of the globule is continuous in order to dissolve or evaporate or disappear once it reaches the parasite, in particular by evaporation.
• This allows the active principle to assume a more or less fluid form and spread outside the parasite to create, as it dries, a more or less sealed film around it.
• the globules are capsules or microcapsules, preferably having a more or less rounded, spherical or ovoidal shape, consisting of a core that is more or less liposoluble enclosed by a wall of a more or less water-dispersible nature, preferably subdivided into an outer wall that is more or less hydrophile and an inner wall that is more or less hydrophobic.
• Advantageous use is made of at least one surfactant or emulsifying agent to keep the globule stable, in particular on the wall around the first active principle.
• the first active principle contains at least one liposoluble compound chosen from the following compounds: vegetable oil, mineral oil, mineral oil substitutes, silicones and triglycerides.
• the composition of the invention includes at least one second active principle designed to act directly on the parasite and its eggs.
• the second active principle includes at least one liposoluble essential oil.
• this liposoluble essential oil will be chosen from among: melaleuca essential oil, matricaria essential oil, lavender essential oil, thyme essential oil, rosemary essential oil or any other essential oil.
• the second active principle is associated with the first active principle and advantageously has a complementary action to the latter.
• the essential oils used advantageously have a more or less insecticidal action and/or an action on the cuticle of the parasite.
• the second active principle is designed to soften the cuticle of the parasite, to weaken it, and to accentuate the destruction of said parasite when combined with the action of the first active principle.
• the globules of the invention includes said first and second encapsulated active principles, preferably a mixture of natural triglycerides, isohexadecane, paraffin, a complex of essential oils (melaleuca, matricaria, lavender, thyme, rosemary%) and water.
• the action mechanism of the proposed product is based on the specific characteristics of the breathing system of insects that are ectoparasites of man in particular Pediculus humanus and insects generally having a length of less than 5 cm.
• insects "breathe” through orifices on the sides of the thorax and abdomen (generally a pair of orifices per anatomic segment, called spriracles.
• spriracles work like valves and are the door to the breathing system distributing oxygen to the insect's hemolymph.
• These valves can close entirely when the insect is no longer in an aerial medium but immersed in water, in a fatty matter or in another liquid. This triggers an effect of apnea, generally called “immersion reflex” causing the spiracles to close and the insect to enter a state of suspended life.
• the composition of the invention that is, advantageously a louse or nit treatment product with a mechanical action
• Pediculus humanus cf. scalp, pubis, animal coat or any other hairy area
• the phenomenon of the asphyxia of the parasite, in particular the louse thanks to the composition of the Invention, takes place in two steps as described below.
• the louse is immersed in a fluid emulsion such as oil in water or water in oil.
• a fluid emulsion such as oil in water or water in oil.
• the solution then penetrates deeply into the breathing system by capillarity or by the mechanical action of the natural breathing in the parasite.
• the reflex of the louse is then to cover its spiracles (breathing orifices) throughout the immersion time, to protect itself from the aqueous medium.
• This stage prevents it from breathing momentarily.
• the louse is only able to resist this anaerobic situation for a few hours. It is a simple matter of maintaining this state for more than 8 hours to kill the parasite.
• the aqueous volatile part of the mixture evaporates at the surface of the insect.
• the product of the invention with its filmogenic properties is then modified and changes from an initial semiliquid state to a semisolid state thanks to spontaneous desiccation favored by the heat from the scalp at approximately 35°C. It then forms a hermetically sealed and flexible residual wall which totally envelopes the parasite in its smallest asperities.
• the ideal formulation for the pediculicide composition on the invention by penetrating the breathing system on the one hand and by covering all the spiracles of the louse without exception, definitively asphyxiates the parasites.
• the phenomenon of the asphyxia of the nit is more complex than that of the louse. Accordingly, the generation of an innovative galenic element called the "meta-emulsion" efficiency destroys the louse and the nit. Indeed, the larvae, protected by the outer shell of the nit, are difficult to reach by any fluid, whether watery or even more so oily. Gas exchanges with the outside are almost nonexistent during the first days and are always passive since the larva is barely beginning its development. There is no active mechanical breathing and it is impossible for the larva to inhale any fluid during its development that could reproduce the mechanism of asphyxia previously described for the louse.
• the particular galenic aspect of the invention composition that is the meta-emulsion, makes it possible to generate globules of a calibrated size included between the 5 and 9 ⁇ , thus allowing passage through the cap via the holes in the louse and the nit.
• the composition of the invention operates according to the same principle of solidification as on the louse.
• the composition then enters a semisolid state which is occlusive and hermetically sealed, making it impossible for the nit to breathe or to hatch.
• the composition preferably blocks the opening mechanism of the cap (a sort of spring naturally pushing against the cap) when the larva, transformed into a young louse, reaches maturity. If the young louse manages to survive its asphyxia, it no longer has any way of getting out of its shell, remaining captive in it and being unable to infest the subject or contaminate other people.
• calibrated meta-emulsion globules are used as vectors for delivering the active principle(s) gradually as they penetrate the respiratory system of the lice and nits.
• composition of the invention advantageously takes the form of a lotion because it allows correct adherence to the hair and uniform spreading over the scalp, in particular when the hair is worn long, much appreciated by the people concerned.
• another presentation as described previously or not is considered, without it being outside the scope of this invention.
• the pediculicide composition of the invention is preferably transparent or translucent to facilitate the examination of the treated area. It is advantageously designed to dry and be eliminated easily when dry, by gentle combing or rinsing in water. Furthermore, preferentially, the composition of the invention is invisible when dry, is odorless and does not stain clothing. Further, the composition is advantageously designed to be moisturizing and soothing to the scalp, a definite novelty compared to insecticidal products which are too often irritating.
• non-aqueous ingredients such as fatty matter, triglycerides, silicones, polymers, Span, Tween, essential oils, etc.
• fatty matter such as fatty matter, triglycerides, silicones, polymers, Span, Tween, essential oils, etc.
• composition of according to the invention will advantageously trigger the apnea of the parasite and, after penetration into the respiratory system in depth, will result in its asphyxia and therefore its death.
• the water and fats are not miscible in all proportions meaning that the meta-emulsion galenic composition of the invention has the twofold technical advantage of emulsifying the two substances into globules on the one hand, and of allowing the calibration of the globules at around 5-9 ⁇ .
• the present invention also concerns a manufacturing process of a composition for the treatment of human or animal pediculosis.
• This composition is advantageously and approximately compliant with that described previously and includes at least one first active principle with filmogenic properties, designed to cover, at least partly, at least one the parasites responsible for said pediculosis, to prevent the latter from breathing.
• the manufacturing process of the invention includes the encapsulation of said at least first active principle in at least one globule whose size is designed to allow the penetration of said globule into the breathing orifices of said at least one parasite and its eggs.
• the globules are lipidic and formulated by a process of a multiplication by phase inversion caused by the passage of the emulsion to beyond the phase inversion temperature, preferentially on the basis of the process described in the French patent application FR-2 849 379.
• this process preserves the active principle by incorporating it in the continuous oily phase, therefore without contact with the aqueous phase, beyond the phase inversion temperature.
• the incorporation of the liposoluble active principle into the formulation at a temperature above the phase inversion temperature that is when emulsion is in the continuous oily phase (water emulsion in oil) produces good distribution of the active principle in the oily phase, limits its contact with the aqueous phase, and surprisingly, although the temperature is high, the dwell time at the temperature being very short because the incorporation is followed by the soaking of the emulsion, degradation phenomena are minimized or eliminated.
• the present invention concerns a process for the encapsulation of the liposoluble active principle in the globules.
• the encapsulation stage includes a substage for the manufacturing of the emulsion during which: a) an aqueous phase and a fatty phase are prepared, b) the temperature of the two phases is increased to a temperature above the phase inversion temperature, c) the two phases are mixed, d) the first liposoluble active principle is added to the liposoluble phase, e) the temperature is reduced to the phase inversion temperature, f) after phase inversion and the obtaining of a continuous aqueous phase emulsion, the emulsion obtained is soaked to bring down its temperature.
• the process includes a sub stage c) designed to reduce the temperature to a temperature immediately above the phase inversion temperature.
• stage c) is carried out before stage b), meaning that the two phases are mixed before the temperature reaches the phase inversion value.
• the first active principle is advantageously dissolved in a fatty phase complement before being incorporated into the liposoluble phase.
• the process of inversion can advantageously be implemented according to various embodiments, for instance by reducing the temperature to a temperature immediately above the phase inversion temperature before the incorporation of the first active principle. Reducing the temperature in this way can be obtained advantageously naturally, or when triggered by the man of the art. It is also entirely acceptable to carry out "soaking" to favor the reducing of the temperature.
• the meta-emulsion obtained in the course of substage f) includes globules more or less rounded in shape with size included approximately between 1 and ⁇ ⁇ ⁇ , preferably included approximately between 5 and 9 ⁇ .
• stage f) of soaking is carried out by adding an aqueous phase complement brought to a temperature at the least below the phase inversion temperature and possibly below the ambient temperature.
• This stage of abrupt and fast cooling reduces the temperature of the emulsion and the exposure time of the active principle to a higher upper temperature.
• This soaking can also be carried out with a cooling system by thermal exchange or by the addition of a liquefied gas, for instance nitrogen.
• the immediately higher temperature refers to the phase inversion temperature higher by a few degrees, in practice 1 or 20°C than the phase inversion temperature.
• the system of phase inversion of temperature has been determined previously by system conductivity monitoring or by individual observation.
• this fatty phase whose composition directly affects the calibration of the globules, includes fats of a paraffin or triglyceride type, or derivatives and/or complexes of paraffin and/or triglycerides.
• the choice of the fatty matter is made advantageously depending on the nature and polarity of the first liposoluble active principle to be encapsulated.
• the first active principle is more or less identical to that described previously, that is, preferentially, a liposoluble compound chosen from between vegetable oils, mineral oils, mineral oil substitutes, silicons and triglycerides.
• this process also allows encapsulation in the globules of at least one second active principle.
• the second active principle is more or less identical to the one described previously, for instance, at least one liposoluble essential oil chosen from among: melaleuca essential oil, matricaria essential oil, lavender essential oil, thyme essential oil, rosemary essential oil or any other essential oil.
• the process of the invention involves other ingredients liable to improve the meta- emulsion of the invention, for instance, emulsifiers, surfactants, antioxidants, preservatives, of which the list is not exhaustive.
• surfactants for instance, glycol esters, glycerol, itol, sorbitan, glycol polyethylene....
• surfactants of a lipophile nature could well be used.
• phase inversion either by the display of the composition whose appearance changes, or by measuring the conductivity.
• the control of the various substages of the process and the different ingredients and active compounds involved in the two phases allows us to obtain an invention composition including calibrated globules capable of entering the breathing orifices of the parasites and their eggs, in particular, lice and nits.
• This invention also concerns, as an intervention in its own right, a lotion for the treatment of pediculosis in man or animal including a composition conforming to the above.
• this lotion is a pediculicidal and lenticidel lotion for the treatment of lice on the scalp and in the hair of man.
• said lotion is packed in a conventional capillary lotion flask, or for instance, in a plastic bottle, more or less opaque, rigid and strong.
• Two phases are prepared with the following ingredients: - For the fatty phase: 35 % Cetiol SN PH, AMI-Cognis, 20 % Cetiol V PH, AMI-Cognis, 19.35% paraffin oil, B2Aiglon (Paraffinum liquidum)/Paraffinum Perliquidium,
• a second active principle based on essential oils is added. It contains 0.2 % of melaleuca essential oil, 0.2 % of matricairia essential oil, 1 .5 % of lavender essential oil, 0.05 thyme oil and 0.05 % rosemary oil. In a solution of hexanoic acid triglyceride, this second active principle is then incorporated into the emulsion obtained by mixing the aqueous phase and the fatty phase at a temperature of around 81 °C.
• phase inversion of detained at 73°C is identified by increasing the conductivity to above 1 30 pS/cm.
• the meta-emulsion is then concentrated to obtain a composition based on the lipid globules having an action against the lice as described previously.
• a phase inversion occurs at 71 °C,
• An aqueous phase made up of: - Chlorhexidin digluconate 0.5 % - water 49.7 %.
• the process of the invention makes it possible to obtain a meta-emulsion which is easy to use for compositions as a treatment for pediculosis in which the globule size is accurately calibrated and adjusted to the orifices of the parasites, more particularly in the region of 5 to 9 ⁇ .
• the smaller the size of the particles the greater the physical stability of the composition because of the disappearance of maturation and coalescence phenomena. Accordingly, the composition obtained corresponds more or less to a monodispersed system in which the globules are more or less of the same size.
• Globules manufactured with this process also have the advantage of leading to improved distribution and reinforced penetration of the active principles into the breathing system of the lice with respect to the active principle, in particular through the caps of the nits.
• the composition of the invention allows the efficient penetration of the active principles into the parasites, whatever their stage of development. Accordingly, we obtain a greater concentration of active principles in the breathing passages of the parasites at every stage of development, without the use of a neurotoxin or an insecticide that could be dangerous to man.
• the present invention also concerns a system for the treatment of human or animal pediculosis including:
• the removal device could advantageously consist of a comb to remove dead parasites, for example a fine toothed louse comb capable of detaching, removing and lifting away dead lice and nits from the hair of the user, after the application of the composition.
• this treatment system is accordingly a way of carrying out the treatment of human pediculosis, preferably a pediculosis and ovacidal treatment kit for man.
• a system like this guarantees in one application, on the one hand, the death of any lice and nits liable to be in the hair and on the scalp and secondly, the complete elimination of these lice and nits by a simple combing gesture.
• the present invention also concerns the use of at least one first active principle having filmogenic properties, encapsulated in at least one globule whose size is designed to allow the penetration of said at least one globule into the breathing orifices of at least one parasite and its eggs, in a composition for the treatment of human or animal pediculosis. Preferably, it involves the use of the previously described composition.
• this invention concerns a process for the treatment of pediculosis in man during which a composition is used including at least one first active principle adding filmogenic properties and designed to cover, at least partly, at least one parasite responsible for said pediculosis, in order to prevent the latter from breathing.
• the process includes a step of penetration of said at least first active principle, which is encapsulated in at least one globule, into the breathing orifices of said at least one parasite and its eggs, size of said globule being designed to allow said penetration into said breathing orifices of said at least one parasite and its eggs.
• the composition conforms with the above and this process represents a pediculicidal and ovacidal treatment for man, through a single application of said composition.
• the treatment process includes a stage for the application of said composition to the scalp and/or hair of user.
• the user pours the composition initially stored in a conventional container, for instance a plastic bottle, directly onto the hair and scalp.
• a conventional container for instance a plastic bottle
• the user can then facilitate the spreading out of the composition, preferably as a lotion, by lightly massaging it into the scalp and hair.
• the treatment process includes a rest stage during which said composition is allowed to stand on the scalp and/or hair of the user so that said composition enters into the breathing orifices of at least one parasite and the eggs of the latter to form a film around them, in particular by the evaporation of at least part of said composition.
• the composition tends to dry out by the evaporation of at least one part of the hydrosoluble components which, combined with the nature of the other components of the composition, modifies the physical phase of the composition which evolves toward the a filmogenic structure which is substantially hermetic and sealed to all fluid.
• the treatment process also includes, preferably, following the rest stage, a washing stage in the course of which the composition on the scalp and/or in the hair of the user is eliminated, at least partially.
• a washing stage in the course of which the composition on the scalp and/or in the hair of the user is eliminated, at least partially.
• the user simply rinses his hair and scalp and may, if he or she wishes, use a conventional shampoo to complete the washing process.
• the treatment process of the invention advantageously includes a combing stage in the course of which the hair is combed to remove any dead parasites.
• this combing stage is carried out using a device for the removal of lice and nits, for instance a fine-toothed louse comb.
• a stage like this advantageously contributes to clearing the hair of any dead parasites not removed by the washing stage.
• This treatment based on the composition of the invention therefore has the advantage of being particularly efficient, simple and fast to implement. In particular, it is a quick means of treating, without any risk of contagion, a large number of users, in particular schoolchildren, or more generally, treated people in a community.
• composition of this invention is also a way of efficiently treating, without a disagreeable odor and without any risk of irritation or side effects or any repetition of the treatment, every stage of human and animal pediculosis.
• the invention could have an industrial application in the definition and manufacturing of compositions for the treatment of pediculosis.

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• 2012
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