EP2821138B8 - Flow cell with integrated dry substance - Google Patents

Flow cell with integrated dry substance Download PDF

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Publication number
EP2821138B8
EP2821138B8 EP13175335.2A EP13175335A EP2821138B8 EP 2821138 B8 EP2821138 B8 EP 2821138B8 EP 13175335 A EP13175335 A EP 13175335A EP 2821138 B8 EP2821138 B8 EP 2821138B8
Authority
EP
European Patent Office
Prior art keywords
flow cell
dry substance
integrated dry
integrated
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP13175335.2A
Other languages
German (de)
French (fr)
Other versions
EP2821138A1 (en
EP2821138B1 (en
EP2821138B2 (en
Inventor
Weber Lutz
Tina Röser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thinxxs Microtechnology GmbH
Original Assignee
Thinxxs Microtechnology GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48745809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP2821138(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to ES13175335T priority Critical patent/ES2704424T5/en
Priority to EP13175335.2A priority patent/EP2821138B2/en
Priority to DK13175335.2T priority patent/DK2821138T4/en
Application filed by Thinxxs Microtechnology GmbH filed Critical Thinxxs Microtechnology GmbH
Priority to US14/902,787 priority patent/US10232367B2/en
Priority to PCT/EP2014/064290 priority patent/WO2015001070A1/en
Priority to CN201480046983.0A priority patent/CN105517710B/en
Publication of EP2821138A1 publication Critical patent/EP2821138A1/en
Publication of EP2821138B1 publication Critical patent/EP2821138B1/en
Priority to US16/265,127 priority patent/US10946376B2/en
Publication of EP2821138B8 publication Critical patent/EP2821138B8/en
Publication of EP2821138B2 publication Critical patent/EP2821138B2/en
Application granted granted Critical
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12—Specific details about manufacturing devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/163—Biocompatibility

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Secondary Cells (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
EP13175335.2A 2013-07-05 2013-07-05 Flow cell with integrated dry substance Active EP2821138B2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES13175335T ES2704424T5 (en) 2013-07-05 2013-07-05 Flow cell with integrated dry substance
EP13175335.2A EP2821138B2 (en) 2013-07-05 2013-07-05 Flow cell with integrated dry substance
DK13175335.2T DK2821138T4 (en) 2013-07-05 2013-07-05 FLOATING CELL WITH INTEGRATED DRY MATERIAL
US14/902,787 US10232367B2 (en) 2013-07-05 2014-07-04 Flow cell with an integrated dry substance
PCT/EP2014/064290 WO2015001070A1 (en) 2013-07-05 2014-07-04 Flow cell with an integrated dry substance
CN201480046983.0A CN105517710B (en) 2013-07-05 2014-07-04 Flow battery with the dry matter integrated
US16/265,127 US10946376B2 (en) 2013-07-05 2019-02-01 Carrier element for introducing a dry substance into a flow cell

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13175335.2A EP2821138B2 (en) 2013-07-05 2013-07-05 Flow cell with integrated dry substance

Publications (4)

Publication Number Publication Date
EP2821138A1 EP2821138A1 (en) 2015-01-07
EP2821138B1 EP2821138B1 (en) 2018-10-24
EP2821138B8 true EP2821138B8 (en) 2019-03-06
EP2821138B2 EP2821138B2 (en) 2022-02-09

Family

ID=48745809

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13175335.2A Active EP2821138B2 (en) 2013-07-05 2013-07-05 Flow cell with integrated dry substance

Country Status (6)

Country Link
US (1) US10232367B2 (en)
EP (1) EP2821138B2 (en)
CN (1) CN105517710B (en)
DK (1) DK2821138T4 (en)
ES (1) ES2704424T5 (en)
WO (1) WO2015001070A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2516675A (en) 2013-07-29 2015-02-04 Atlas Genetics Ltd A valve which depressurises, and a valve system
GB2516669B (en) 2013-07-29 2015-09-09 Atlas Genetics Ltd A method for processing a liquid sample in a fluidic cartridge
GB2516672B (en) 2013-07-29 2015-05-20 Atlas Genetics Ltd A system and method for expelling liquid from a fluidic cartridge
GB2516666B (en) 2013-07-29 2015-09-09 Atlas Genetics Ltd Fluidic cartridge for nucleic acid amplification and detection
GB2516667A (en) 2013-07-29 2015-02-04 Atlas Genetics Ltd An improved cartridge, cartridge reader and method for preventing reuse
US9610579B2 (en) 2014-01-07 2017-04-04 Daktari Diagnostics, Inc. Fluid delivery devices, systems, and methods
KR20170066498A (en) 2014-09-29 2017-06-14 칩케어 코포레이션 A device for optical detection of cells comprising a cartridge and fluidic chip and methods thereof
WO2016083898A1 (en) 2014-11-28 2016-06-02 Chipcare Corporation Multiplex bead array assay
EP3108962A1 (en) * 2015-06-22 2016-12-28 Thinxxs Microtechnology Ag Sample carrier
EP3199240A1 (en) * 2016-01-26 2017-08-02 ThinXXS Microtechnology AG Microfluidic flow cell with integrated electrode and method for producing the same
EP3263215B1 (en) * 2016-06-30 2021-04-28 ThinXXS Microtechnology AG Device with a flow cell with reagent storage
WO2018065107A1 (en) 2016-10-07 2018-04-12 Boehringer Ingelheim Vetmedica Gmbh Cartridge for testing a sample and method for producing a cartridge of this kind
WO2018122856A1 (en) 2016-12-29 2018-07-05 Dalibor Hodko An electrophoretic chip for electrophoretic applications
EP3342485B1 (en) * 2017-01-02 2020-07-08 Thinxxs Microtechnology Ag Holder for reagent elements
EP3444034A1 (en) 2017-08-18 2019-02-20 XanTec bioanalytics GmbH Flow cell for the selective enrichment of target particles or cells
US10046322B1 (en) 2018-03-22 2018-08-14 Talis Biomedical Corporation Reaction well for assay device
EP3818067A4 (en) 2018-07-04 2022-06-29 Ador Diagnostics Ltd. System, apparatus and method for computerized automatic diagnosis
GB201819415D0 (en) 2018-11-29 2019-01-16 Quantumdx Group Ltd Microfluidic apparatus and method
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
GB201917832D0 (en) 2019-12-05 2020-01-22 Oxford Nanopore Tech Ltd Microfluidic device for preparing and analysing a test liquid
EP4173708A1 (en) 2021-10-28 2023-05-03 thinXXS Microtechnology GmbH Microfluidic element, in particular a flow cell with integrated drying reagent
WO2024038109A1 (en) * 2022-08-17 2024-02-22 Thinxxs Microtechnology Gmbh Microfluidic flow cell, production method, use and analysis device

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5725831A (en) * 1994-03-14 1998-03-10 Becton Dickinson And Company Nucleic acid amplification apparatus
US6488828B1 (en) * 2000-07-20 2002-12-03 Roche Diagnostics Corporation Recloseable biosensor
JP4013671B2 (en) * 2002-07-05 2007-11-28 松下電器産業株式会社 Polymerase chain reaction vessel and method for producing the same
DE10336849A1 (en) 2003-08-11 2005-03-10 Thinxxs Gmbh flow cell
DE102004021780B4 (en) 2004-04-30 2008-10-02 Siemens Ag Method and device for DNA isolation with dry reagents
JP4546534B2 (en) * 2004-10-15 2010-09-15 シーメンス アクチエンゲゼルシヤフト Comprehensive and automatic analyzer for DNA or protein in a disposable cartridge, method for manufacturing such cartridge, and operating method for DNA or protein analysis using such cartridge
EP1963853B1 (en) * 2005-12-21 2016-03-09 Meso Scale Technologies, LLC Assay modules having assay reagents and methods of making and using same
ES2453379T3 (en) 2007-04-25 2014-04-07 3M Innovative Properties Company Supported reagents, methods and devices
DE102008021364A1 (en) 2008-04-29 2009-06-25 Siemens Aktiengesellschaft Charging dry reagents into analysis unit used e.g. in biotechnology and genetic engineering, applies dry reagents to transfer reservoir to be brought into contact with analysis unit
KR101102532B1 (en) 2008-07-10 2012-01-03 삼성전자주식회사 Cartridge containing reagent therein, microfluidic device having the cartridge, manufacturing method of the microfluidic device, biochemistry analysis method using microfluidic device
EP2198964B8 (en) 2008-11-06 2013-04-24 F. Hoffmann-La Roche AG Method of providing a dry reagent in a micro-fluid system
GB0919159D0 (en) 2009-11-02 2009-12-16 Sec Dep For Environment Food A Device and apparatus
KR101851117B1 (en) 2010-01-29 2018-04-23 마이크로닉스 인코포레이티드. Sample-to-answer microfluidic cartridge
GB2483077A (en) * 2010-08-25 2012-02-29 Concateno Uk Ltd Sample testing assay apparatus and method
WO2012142397A2 (en) * 2011-04-13 2012-10-18 Akonni Biosystems, Inc. Microarray based sample detection system
AU2012250917B2 (en) * 2011-05-02 2015-09-17 Advanced Liquid Logic, Inc. Molecular diagnostics platform
US9709580B2 (en) * 2011-05-12 2017-07-18 William Marsh Rice University Bio-nano-chips for on-site drug screening
EP2610009A1 (en) 2011-12-29 2013-07-03 Samsung Electronics Co., Ltd Solid reagent dissolving device and method of dissolving solid reagent by using the same
US20150241319A1 (en) * 2012-09-26 2015-08-27 Thomas N. Chiesl Swab interface for a microfluidic device

Also Published As

Publication number Publication date
ES2704424T5 (en) 2022-05-20
DK2821138T3 (en) 2019-02-11
EP2821138A1 (en) 2015-01-07
US10232367B2 (en) 2019-03-19
DK2821138T4 (en) 2022-05-16
CN105517710B (en) 2017-04-05
US20160167047A1 (en) 2016-06-16
EP2821138B1 (en) 2018-10-24
WO2015001070A1 (en) 2015-01-08
EP2821138B2 (en) 2022-02-09
ES2704424T3 (en) 2019-03-18
CN105517710A (en) 2016-04-20

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