EP2793905B1 - Ellagitannins rich extracts composition in sexual wellness - Google Patents
Ellagitannins rich extracts composition in sexual wellness Download PDFInfo
- Publication number
- EP2793905B1 EP2793905B1 EP12816068.6A EP12816068A EP2793905B1 EP 2793905 B1 EP2793905 B1 EP 2793905B1 EP 12816068 A EP12816068 A EP 12816068A EP 2793905 B1 EP2793905 B1 EP 2793905B1
- Authority
- EP
- European Patent Office
- Prior art keywords
- extracts
- sexual
- composition
- ellagitannins
- plant extracts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims description 66
- 230000001568 sexual effect Effects 0.000 title claims description 58
- 239000000284 extract Substances 0.000 title claims description 48
- 229920001968 ellagitannin Polymers 0.000 title claims description 35
- 239000000419 plant extract Substances 0.000 claims description 27
- 241000219492 Quercus Species 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 16
- 229930184182 roburin Natural products 0.000 claims description 15
- 240000009089 Quercus robur Species 0.000 claims description 14
- 235000015872 dietary supplement Nutrition 0.000 claims description 14
- 235000011471 Quercus robur Nutrition 0.000 claims description 13
- 201000001880 Sexual dysfunction Diseases 0.000 claims description 13
- 238000002360 preparation method Methods 0.000 claims description 13
- 231100000872 sexual dysfunction Toxicity 0.000 claims description 13
- 241000219428 Fagaceae Species 0.000 claims description 11
- 235000013305 food Nutrition 0.000 claims description 11
- 241001070941 Castanea Species 0.000 claims description 7
- 235000014036 Castanea Nutrition 0.000 claims description 7
- 241001070947 Fagus Species 0.000 claims description 6
- 235000013361 beverage Nutrition 0.000 claims description 6
- 239000002417 nutraceutical Substances 0.000 claims description 6
- 235000021436 nutraceutical agent Nutrition 0.000 claims description 6
- 230000036299 sexual function Effects 0.000 description 15
- 239000003814 drug Substances 0.000 description 14
- 235000016976 Quercus macrolepis Nutrition 0.000 description 11
- 239000000546 pharmaceutical excipient Substances 0.000 description 11
- 239000002023 wood Substances 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 201000001881 impotence Diseases 0.000 description 7
- 239000003826 tablet Substances 0.000 description 7
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 6
- 235000013399 edible fruits Nutrition 0.000 description 6
- 230000009986 erectile function Effects 0.000 description 6
- 230000006872 improvement Effects 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 229920001865 Castalagin Polymers 0.000 description 5
- 230000037007 arousal Effects 0.000 description 5
- UDYKDZHZAKSYCO-CIBWSTISSA-N castalagin Chemical compound C([C@H]1OC(=O)C2=CC(O)=C(O)C(O)=C2C=2C(O)=C(O)C(O)=C(C=2C(=O)O2)C3=C(O)C(O)=C4O)OC(=O)C5=CC(O)=C(O)C(O)=C5C5=C(O)C(O)=C(O)C=C5C(=O)O[C@H]1[C@H]2[C@@H]1[C@@H](O)C4=C3C(=O)O1 UDYKDZHZAKSYCO-CIBWSTISSA-N 0.000 description 5
- FTFKAWWJGCCSJT-UHFFFAOYSA-N castalagin Natural products OC1OC2C(O)c3c(O)c(O)c(O)c(c13)c4c(O)c(O)c(O)c5c4C(=O)OC2C6OC(=O)c7cc(O)c(O)c(O)c7c8c(O)c(O)c(O)cc8C(=O)OCC6OC(=O)c9cc(O)c(O)c(O)c59 FTFKAWWJGCCSJT-UHFFFAOYSA-N 0.000 description 5
- -1 coatings Substances 0.000 description 5
- 208000035475 disorder Diseases 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 230000035911 sexual health Effects 0.000 description 5
- 208000010228 Erectile Dysfunction Diseases 0.000 description 4
- SCGCYQONNCQISP-UHFFFAOYSA-N Vescalin Natural products OCC1OC(=O)c2cc(O)c(O)c(O)c2c3c(O)c(O)c(O)cc3C(=O)OC(C1O)C4OC(=O)c5cc(O)c(O)c(O)c5C4O SCGCYQONNCQISP-UHFFFAOYSA-N 0.000 description 4
- 235000003599 food sweetener Nutrition 0.000 description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 239000011707 mineral Substances 0.000 description 4
- 235000010755 mineral Nutrition 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 230000035946 sexual desire Effects 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 239000003765 sweetening agent Substances 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 230000000699 topical effect Effects 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 208000004483 Dyspareunia Diseases 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 208000006262 Psychological Sexual Dysfunctions Diseases 0.000 description 3
- 244000274906 Quercus alba Species 0.000 description 3
- 235000009137 Quercus alba Nutrition 0.000 description 3
- 240000008751 Quercus petraea Species 0.000 description 3
- 240000008289 Quercus suber Species 0.000 description 3
- 235000016977 Quercus suber Nutrition 0.000 description 3
- UDYKDZHZAKSYCO-WETOHNLWSA-N Vescalagin Natural products O=C1O[C@H]2[C@H](O)c3c(O)c(O)c(O)c(-c4c(O)c(O)c(O)c5-c6c(O)c(O)c(O)cc6C(=O)O[C@@H]6[C@H](OC(=O)c7c(c(O)c(O)c(O)c7)-c7c(O)c(O)c(O)cc7C(=O)OC6)[C@H]2OC(=O)c45)c13 UDYKDZHZAKSYCO-WETOHNLWSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000000378 dietary effect Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000001856 erectile effect Effects 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000006187 pill Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 229960003604 testosterone Drugs 0.000 description 3
- QJYNZEYHSMRWBK-NIKIMHBISA-N 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose Chemical compound OC1=C(O)C(O)=CC(C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(O)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(O)C(O)=C(O)C=2)=C1 QJYNZEYHSMRWBK-NIKIMHBISA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 229920001757 Castalin Polymers 0.000 description 2
- PPUHUWSVCUJGTD-UTSKMKSGSA-N Castalin Natural products O=C1O[C@H]2[C@H](O)c3c(O)c(O)c(O)c(-c4c(O)c(O)c(O)c5-c6c(O)c(O)c(O)cc6C(=O)O[C@@H](CO)[C@@H](O)[C@H]2OC(=O)c45)c13 PPUHUWSVCUJGTD-UTSKMKSGSA-N 0.000 description 2
- 240000007857 Castanea sativa Species 0.000 description 2
- 235000014037 Castanea sativa Nutrition 0.000 description 2
- 235000010099 Fagus sylvatica Nutrition 0.000 description 2
- 208000021663 Female sexual arousal disease Diseases 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 235000002913 Quercus petraea Nutrition 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000003098 androgen Substances 0.000 description 2
- PPUHUWSVCUJGTD-UHFFFAOYSA-N castalin Chemical compound OC1C(CO)OC(=O)C2=CC(O)=C(O)C(O)=C2C2=C(O)C(O)=C(O)C(C3=C(O)C(O)=C4O)=C2C(=O)OC1C1C(O)C4=C3C(=O)O1 PPUHUWSVCUJGTD-UHFFFAOYSA-N 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 239000007799 cork Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000035558 fertility Effects 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 229960002737 fructose Drugs 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 229920002824 gallotannin Polymers 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000010903 husk Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007937 lozenge Substances 0.000 description 2
- 238000005461 lubrication Methods 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 230000009245 menopause Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000004043 responsiveness Effects 0.000 description 2
- 230000035936 sexual power Effects 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000036642 wellbeing Effects 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- ICLYJLBTOGPLMC-KVVVOXFISA-N (z)-octadec-9-enoate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCC\C=C/CCCCCCCC(O)=O ICLYJLBTOGPLMC-KVVVOXFISA-N 0.000 description 1
- 229920002793 1,2,3,4,6-Pentagalloyl glucose Polymers 0.000 description 1
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010002942 Apathy Diseases 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000195940 Bryophyta Species 0.000 description 1
- 241000282836 Camelus dromedarius Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 206010011971 Decreased interest Diseases 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 description 1
- 229920002079 Ellagic acid Polymers 0.000 description 1
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- 244000222296 Fagus americana Species 0.000 description 1
- 235000018241 Fagus americana Nutrition 0.000 description 1
- 240000000731 Fagus sylvatica Species 0.000 description 1
- 244000219546 Fagus sylvatica subsp sylvatica Species 0.000 description 1
- 235000004994 Fagus sylvatica subsp sylvatica Nutrition 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920001908 Hydrogenated starch hydrolysate Polymers 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010024419 Libido decreased Diseases 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000009328 Perro Species 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 244000198546 Quercus robur subsp brutia Species 0.000 description 1
- 235000008386 Quercus robur subsp brutia Nutrition 0.000 description 1
- 244000184028 Quercus robur subsp robur Species 0.000 description 1
- 241000920577 Quercus robur subsp. pedunculiflora Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 229920002358 Roburin A Polymers 0.000 description 1
- 208000029901 Sexual arousal disease Diseases 0.000 description 1
- 208000030047 Sexual desire disease Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 208000027520 Somatoform disease Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 206010047791 Vulvovaginal dryness Diseases 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000003070 absorption delaying agent Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 229940030486 androgens Drugs 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 230000000181 anti-adherent effect Effects 0.000 description 1
- 239000003911 antiadherent Substances 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007961 artificial flavoring substance Substances 0.000 description 1
- 235000021311 artificial sweeteners Nutrition 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000003840 blood vessel health Effects 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000007894 caplet Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- YTJJRAWFHJBAMT-UHFFFAOYSA-N depside Natural products OC(=O)CC1=C(O)C=C(O)C=C1OC(=O)C1=CC=C(O)C(O)=C1 YTJJRAWFHJBAMT-UHFFFAOYSA-N 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000002612 dispersion medium Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 235000004132 ellagic acid Nutrition 0.000 description 1
- 229960002852 ellagic acid Drugs 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 235000020774 essential nutrients Nutrition 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 239000007902 hard capsule Substances 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 235000019534 high fructose corn syrup Nutrition 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 229920001461 hydrolysable tannin Polymers 0.000 description 1
- 229940060367 inert ingredients Drugs 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 229960004903 invert sugar Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000000905 isomalt Substances 0.000 description 1
- 235000010439 isomalt Nutrition 0.000 description 1
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- BJHIKXHVCXFQLS-PQLUHFTBSA-N keto-D-tagatose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-PQLUHFTBSA-N 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 229960003451 lactitol Drugs 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 1
- 239000004530 micro-emulsion Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 239000004050 mood stabilizer Substances 0.000 description 1
- 229940127237 mood stabilizer Drugs 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 235000021096 natural sweeteners Nutrition 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 208000024309 orgasm disease Diseases 0.000 description 1
- 239000002357 osmotic agent Substances 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000006179 pH buffering agent Substances 0.000 description 1
- 208000027753 pain disease Diseases 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 210000003899 penis Anatomy 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 235000009048 phenolic acids Nutrition 0.000 description 1
- 150000007965 phenolic acids Chemical class 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 235000017924 poor diet Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 235000021067 refined food Nutrition 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- ZRHBFKOPSQICED-UHFFFAOYSA-N roburin A Natural products OC1C2OC(=O)c3c1c(O)c(O)c(O)c3c4c(O)c(O)c(O)c5c4C(=O)OC2C6OC(=O)c7cc(O)c(O)c(O)c7c8c(O)c(O)c(Oc9cc%10C(=O)OC%11COC(=O)c%12cc(O)c(O)c(O)c%12c%13c(O)c(O)c(O)cc%13C(=O)OC%11C%14OC(=O)c%15c(c(O)c(O)c(O)c%15c%16c(O)c(O)c(O)c%17C(O)C%14OC(=O)c%16%17)c%10c(O)c9O)cc8C(=O)OCC6OC(=O)c%18cc(O)c(O)c(O)c5%18 ZRHBFKOPSQICED-UHFFFAOYSA-N 0.000 description 1
- QTCMAUFCWPWEDU-UHFFFAOYSA-N roburin D Natural products O1C(=O)C2=C3C(O)=C(O)C(O)=C2C(C=2C(=O)O4)=C(O)C(O)=C(O)C=2C2=C(O)C(O)=C(O)C=C2C(=O)OC2COC(=O)C5=CC(O)=C(O)C(O)=C5C5=C(O)C(O)=C(O)C=C5C(=O)OC2C4C1C3C1=C2C(=O)OCC3OC(=O)C4=CC(O)=C(O)C(O)=C4C(C(O)=C(O)C(O)=C4C5=C(O)C(O)=C(O)C6=C5C(=O)OC5C6O)=C4C(=O)OC5C3OC(=O)C3=CC(O)=C(O)C(O)=C3C2=C(O)C(O)=C1O QTCMAUFCWPWEDU-UHFFFAOYSA-N 0.000 description 1
- 230000036332 sexual response Effects 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229960004249 sodium acetate Drugs 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 230000007103 stamina Effects 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940117013 triethanolamine oleate Drugs 0.000 description 1
- 206010046947 vaginismus Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 230000005186 women's health Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7024—Esters of saccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/49—Fagaceae (Beech family), e.g. oak or chestnut
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the present invention relates to a composition consisting of ellagitannins rich extracts originating from plant extracts of the Fagaceae family, for use in a method for improving sexual fitness or wellness of both sexes, the male sexual enhancement, the treatment or prevention of sexual dysfunction in both sexes.
- Vaginal dryness is progressively more frequent with age, and vaginal infections are more common with increasing age and in diabetic women. They may cause sexual dysfunction (SD), loss of interest, and difficult or painful intercourse that can be associated with anxiety and fear, contributing to a lack of motivation.
- SD sexual dysfunction
- loss of interest loss of interest
- difficult or painful intercourse that can be associated with anxiety and fear
- the family Fagaceae or beech family, comprises about 900 species of both evergreen and deciduous trees and shrubs, which are characterized by alternate simple leaves with pinnate venation, unisexual flowers in the form of catkins, and fruit in the form of cup-like (cupule) nuts. Fagaceous leaves are often lobed and both petioles and stipules are generally present. Fruits lack endosperm and lie in a scaly or spiny husk that may or may not enclose the entire nut, which may consist of one to seven seeds.
- the best-known group of this family is the oaks, genus Quercus, the fruit of which is a non-valved nut (usually containing one seed) called an acorn. The husk of the acorn in most oaks only forms a cup in which the nut sits.
- a composition consisting of ellagitannins rich extracts originating from plant extracts of the Fagaceae family, wherein said extracts are natural extracts having more than 50% w/w of ellagitannins based on dried extract or having ellagitannins at a concentration of at least 10% of the total weight of said composition, for use in a method for the treatment or prevention of sexual dysfunction in both sexes.
- compositions that, when administered, offers both sex a safe, natural way to preserve and maintain sexual responsiveness, endurance and enjoyment. It includes a blend or composition consisting of ellagitannins rich extracts originated from plants of the Fagacaea family. When the blend is administered, or taken on a daily basis over a period of time, sexual fitness or sexual wellness improves by the end of the period of time.
- the present invention provides for an oral administration in the form of a dietary or food supplement, a food preparation, a beverage, a medicament or for a topical preparation comprising the composition of the present invention.
- compositions consisting of ellagitannins rich extracts originating from plant extracts of the Fagaceae family, wherein said extracts are natural extracts having more than 50% w/w of ellagitannins based on dried extract or having ellagitannins at a concentration of at least 10% of the total weight of said composition, for the improving of sexual fitness or wellness or the sexual enhancement in both sexes.
- extract includes any preparation obtained from plants, fruits, roots or vegetables using an extraction method.
- food preparation refers generally to material of either plant or animal origin, or of synthetic sources, that contain essential nutrients such as a carbohydrate, protein, fat, vitamin, mineral, etc. used in the body of an organism to sustain growth, repair, and vital processes and to furnish energy.
- a “dietary or food supplement” refers to a product that contains substances like vitamins, minerals, foods, botanicals, amino acids and is intended to supplement the usual intake of these substances. Dietary supplements are found in pill, tablet, capsule, powder or liquid form and are meant to be taken by mouth.
- the term "nutraceutical” refers to any substance that is a food or a part of a food and provides medical or health benefits, including the prevention and treatment of disease. Such products may range from isolated nutrients, dietary supplements and specific diets to genetically engineered designer foods, herbal products, and processed foods such as cereals, soups and beverages. It also refers to a product isolated or purified from foods, and generally sold in medicinal forms not usually associated with food and demonstrated to have a physiological benefit or provide protection against diseases like chronic diseases for example.
- beverage means a liquid for drinking, which may be water, flavored water, soft drinks, alcoholic drink, health drink, or an enriched drink like based on a diary product (milk) or fruit juice.
- “Pharmaceutically acceptable excipients or carriers” are any materials that do not interfere with the pharmacological activity of the active ingredient(s) or degrade the body functions of the subject to which it can be administered but facilitate fabrication of dosage forms or administration of the composition.
- pharmaceutically acceptable excipient include but are not limited to maltodextrin, calcium phosphate, and fused silica.
- compositions also include flavorants, as well as various additives such as other vitamins and minerals, all solvents, dispersion media, coatings, isotonic and absorption delaying agents, sweeteners and the like, non-toxic auxiliary substances such as wetting or emulsifying agents, pH buffering agents and the like, such as for example, sodium acetate, sorbitan monolaurate, triethanolamine oleate, and inert ingredients such as talc and magnesium stearate which are standard excipients in the manufacture of tablets, capsules and other dosage forms.
- flavorants as well as various additives such as other vitamins and minerals, all solvents, dispersion media, coatings, isotonic and absorption delaying agents, sweeteners and the like, non-toxic auxiliary substances such as wetting or emulsifying agents, pH buffering agents and the like, such as for example, sodium acetate, sorbitan monolaurate, triethanolamine oleate, and inert ingredients such as talc and magnesium stea
- the terms "subject” or “patient” are well-recognized in the art, and, are used interchangeably herein to refer to a mammal, including dog, cat, rat, mouse, monkey, cow, horse, goat, sheep, pig, camel, and, most preferably, a human.
- the subject is a subject in need of treatment or a subject with a disease or disorder.
- the subject can be a normal subject.
- the term does not denote a particular age or sex. Thus, adult and newborn subjects, whether male or female, are intended to be covered.
- an effective amount refers to an amount necessary to obtain a physiological effect.
- the physiological effect may be achieved by one application dose or by repeated applications.
- the dosage administered may, of course, vary depending upon known factors, such as the physiological characteristics of the particular composition; the age, health and weight of the subject; the nature and extent of the symptoms; the kind of concurrent treatment; the frequency of treatment; and the effect desired and can be adjusted by a person skilled in the art.
- prevention and preventing when referring to a disorder or symptom, refers to a reduction in the risk or likelihood that a mammalian subject will develop said disorder, symptom, condition, or indicator after treatment according to the invention, or a reduction in the risk or likelihood that a mammalian subject will exhibit a recurrence of said disorder, symptom, condition, or indicator once a subject has been treated according to the invention and cured or restored to a normal state.
- treatment when referring to sexual dysfunction, sexual fitness or wellness, sexual enhancement in both sexes, refers to inhibiting or reducing the progression, nature, or severity of the subject condition or delaying the onset of the condition.
- the present invention provides a composition consisting of ellagitannins rich extracts originating from plant extracts of the Fagaceae family, wherein said extracts are natural extracts having more than 50% w/w of ellagitannins based on dried extract or having ellagitannins at a concentration of at least 10% of the total weight of said composition, for use in a method for treating or preventing sexual dysfunction, as well as the use of said composition for improving sexual fitness or wellness, or for improving sexual enhancement in both sexes.
- Ellagitannins of the invention are originating from a plant extract or from a synthesized material.
- said ellagitannins rich extracts originated from plant extracts of the Fagacaea family comprise Roburins or derivatives thereof as defined below.
- the plant extracts of the Fagacaea family consists of Quercus robur extracts as defined above.
- Another aspect of the invention resides in a composition that, when administered, offers both sex a safe, natural way to preserve and maintain sexual responsiveness, endurance and enjoyment.
- Also encompassed by the present invention is a method for improving sexual fitness or wellness of both sexes comprising administering to a subject in need thereof an effective amount of the composition or the medicament of the invention.
- the invention also provides for a method for improving man and female sexual enhancement comprising administering to a subject in need thereof an effective amount of the composition or the medicament of the invention.
- the invention also concerns a method of treating or preventing sexual dysfunction in both sexes comprising administering to a subject in need thereof an effective amount of the preparation or the medicament according to the invention.
- the methods according to the invention enhance a level of sexual wellness for both sexes.
- the composition of the invention being in therapeutically effective amounts so that, when the composition is administered at least daily over a period of time, in a sufficient amount, it enhances a level of sexual wellness by an end of the period of time.
- the methods of the invention also help in attaining enhanced sexual wellness.
- the administering includes initially administering an elevated dosage of the composition of the invention to attain the enhanced level of sexual wellness by the end of the period of time and thereafter administering a dosage of the composition daily that contains less of the composition than the elevated dosage and still provide the enhanced level of sexual wellness.
- “Fitness”, whether "sexual fitness” or physical fitness, is defined as a measure of efficient functioning.
- a person who is sexually fit is efficient in their capacity to think, feel, and behave in a sexual manner without shame, embarrassment, or hidden agendas of falsely boosting their ego or self-esteem.
- People who reach and practice this style of fitness are more likely to function efficiently in all aspects of their perceptual world. These fortunate individuals are more confident, physically ill less often, and manage stressful events more successfully.
- Sexual fitness is an achieved state of being allowing people to perform better in every action they engage in. Having this capability affords person to feel confident in all situations whether a partner is involved or not.
- “Sexual wellness” of both sexes is the active participation of the individual in his or her life by addressing the numerous issues within sexual health.
- the process defined as sexual wellness is to improved sexual health.
- “Sexual health” is a state of physical, mental and social well-being in relation to sexuality. It requires a positive and respectful approach to sexuality and sexual relationships, as well as the possibility of having pleasurable and safe sexual experiences, free of coercion, discrimination and violence (definition WHO 2002).
- Sexual health is the integration of the somatic, emotional, intellectual, and social aspects of sexual being, in ways that are positively enriching and that enhance personality, communication, and love. Fundamental to this concept are the right to sexual information and the right to pleasure (definition of WHO 1975). Sexual health is inextricably bound to both physical and mental health.
- “Male sexual enhancement” may be defined as the increase of the hardness of erection; the improvement of self-confidence; the improvement of sperm quality, count and motility (spontaneous motion) and fertility; the increase of libido and sex drive; the boosting of the sexual energy level and vitality; the improvement of sexual performance problems i.e. those due to aging as well as the increase of energy and the greater sexual satisfaction with a partner. Men's sexual function is scored using the established "International Index of Erectile Function” (IIEF) questionnaire [ Rosen et al., Urology.
- IIEF International Index of Erectile Function
- IIEF international index of erectile function
- “Female sexual enhancement” is defined as anything that enhances a woman's sexuality; this includes in particular the increase of libido or sex drive.
- Low libido or sex drive in women can be caused by a number of factors that vary from one woman to another; fatigue, mild depression, and the multiple roles that women play in daily life can cause psychological issues, which can have an affect on a woman's sexual appetite.
- Antidepressants, birth control, tranquilizers and mood stabilizers also impact sexual activity and other conditions like diabetes, heart disease and a poor diet can also reduce a woman's sex drive.
- Women's sexuality level may be determined by the Female Sexual Function Index (FSFI) and the Women's Health Questionnaire (WHQ) which are defined and detailed in example 4.
- FSFI Female Sexual Function Index
- WHQ Women's Health Questionnaire
- “Sexual dysfunction” or sexual malfunction in both sexes refers to a difficulty experienced by an individual or a couple during any stage of a normal sexual activity, including desire, arousal or orgasm.
- Sexual desire disorders or decreased libido are characterized by a lack or absence for some period of time of sexual desire or libido for sexual activity or of sexual fantasies.
- Sexual arousal disorders were previously known as frigidity in women and impotence in men, though these have now been replaced with less judgmental terms.
- Impotence is now known as erectile dysfunction, and frigidity has been replaced with a number of terms describing specific problems with, for example, desire or arousal.
- these conditions can manifest themselves as an aversion to, and avoidance of, sexual contact with a partner.
- men there may be partial or complete failure to attain or maintain an erection, or a lack of sexual excitement and pleasure in sexual activity.
- Erectile dysfunction or impotence is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis.
- the causes of erectile dysfunction may be psychological or physical.
- Orgasm disorders are persistent delays or absence of orgasm following a normal sexual excitement phase.
- the disorder can have physical, psychological, or pharmacological origins.
- dyspareunia Painful intercourse
- vaginismus an involuntary spasm of the muscles of the vaginal wall that interferes with intercourse.
- blend/composition according to the present invention which is a natural dietary supplement, offers a safe, natural and cost-effective alternative.
- ellagitannins rich extracts are also referred as "ellagitannins rich extracts".
- the ellagitannins are a diverse class of hydrolyzable tannins, a type of polyphenol formed primarily from the oxidative linkage of galloyl groups in 1,2,3,4,6-Pentagalloyl glucose.
- Ellagitannins differ from gallotannins, in that their galloyl groups are linked through C-C bonds, whereas the galloyl groups in gallotannins are linked by depside bonds.
- Ellagitannins comprise (Roburins A, B, C, D, E, Vescalin, Castalin, Vescalagin, Castalagin).
- said ellagitannins rich extracts originated from plant extracts of the Fagacaea family comprise Roburins or derivatives thereof.
- Roburins include Roburins A, B, C, D, E
- the term "Roburins" will be considered as equivalent to Roburins A, B, C, D, E and are interchangeable.
- Roburin A is a tannin found for example in oak wood ( Quercus robur and Quercus petraea or Quercus alba ) or oak cork ( Quercus suber ). It is a dimeric compound, composed of two vescalagin subunits probably linked through an ether bond between the diphenoyl group of one subunit and the triphenoyl moiety of the other one.
- the plant extracts of the Fagacaea family are selected among genera Quercus, Castanea, and Fagus or mixtures thereof.
- Fagaceae particularly worthy of mention are the Fagus grandifolia, common beech (Fagus sylvatica), sweet chestnut (Castanea sativa) and English oak (Quercus robur).
- the plant extracts of the Fagacaea family consists of oak woods extracts.
- the plant extracts of the Fagacaea family consists of Quercus robur extracts.
- Quercus robur also known as "oak wood” belongs to the family of Fagaceae and the genus Quercus. Quercus robur (sometimes considered Q. pedunculata ) is commonly known as Pedunculate oak or English oak. Also included in this definition of "oak wood” is the white oak, Quercus alba, Quercus brutia Tenore, Q. pedunculiflora, Q. haas as well as the Sessile Oak (Q. petraea ) . In the present invention the term “Quercus robur” will be considered as equivalent to oak wood as defined above, they are interchangeable.
- Oak wood is traditionally used to make wine barrels and is known to give its taste to wine and to contribute to its antioxidant activity.
- Fresh wood chips used for Bio prises extract are purchased from a famous wine barrel maker (http://www.dargaud-jaegle.com/) and obtained from Oak trees rigorously selected. The extraction process is carried out by water extraction at low temperature (50°C) and spray drying. No petrochemical solvent is used.
- Oak wood extract contains ellagitannins (Roburins A, B, C, D, E, Vescalin, Castalin, Vescalagin, Castalagin) and phenolic acids (gallic acid, ellagic acid).
- composition consisting of ellagitannins, present in the preparation of the invention is originating from a plant extract or alternatively from a synthesized material (i.e., synthetic ellagitannins, i.e. roburins).
- Ellagitannins containing rich extracts are natural and preferably plant extracts having more than 50% by weight (of dried extracts) of ellagitannins (in particular roburins), more preferably more than 70% by weight and even more preferably more than 75% by weight of ellagitannins (in particular roburins).
- the plant extract according to the present invention is originated from oak wood extracts and more preferably the plant extract is Quercus robur.
- the composition may contain ellagitannins (in particular roburins) at a concentration of 10% to 100% of total weight.
- the composition of the invention may be diluted or concentrated to contain 10%, 20%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 90% or 95% ellagitannins (in particular roburins). Concentration may be performed using known methods such as column chromatography or affinity chromatography.
- composition of the invention may further comprise vitamins, coenzymes, mineral substances, aminoacids and antioxidants and/or a suitable excipient q.s.p.
- the composition may be manufactured in the form of tablets, lozenges, capsules, pills, granulates, syrups, vials or drops.
- the suitable excipient of the invention is an acceptable excipient or carrier as defined above.
- suitable excipients of this invention include, but are not limited to, anti-adherents, binders (e.g., macrocrystalline cellulose, gum tragacanth, or gelatin), coatings, disintegrants, fillers, diluents, softeners, emulsifiers, flavoring agents, coloring agents, adjuvants, lubricants, functional agents (e.g., nutrients), viscosity modifiers, bulking agents, glidiants (e.g., colloidal silicon dioxide) surface active agents, osmotic agents, diluents, or any other non-active ingredient, or combinations thereof.
- anti-adherents binders (e.g., macrocrystalline cellulose, gum tragacanth, or gelatin), coatings, disintegrants, fillers, diluents, softeners, emulsifiers, flavoring agents, coloring agents, adju
- composition of the present invention may further include excipient materials selected from the group consisting of calcium carbonate, coloring agents, whiteners, preservatives, and flavors, triacetin, magnesium stearate, sterotes, natural or artificial flavors, essential oils, plant extracts, fruit essences, gelatins, or combinations thereof.
- excipient materials selected from the group consisting of calcium carbonate, coloring agents, whiteners, preservatives, and flavors, triacetin, magnesium stearate, sterotes, natural or artificial flavors, essential oils, plant extracts, fruit essences, gelatins, or combinations thereof.
- composition of the present invention may include other artificial or natural sweeteners, bulk sweeteners, or combinations thereof.
- Bulk sweeteners include both caloric and non-caloric compounds.
- Non-limiting examples of bulk sweeteners include sucrose, dextrose, maltose, dextrin, dried invert sugar, fructose, high fructose corn syrup, levulose, galactose, corn syrup solids, tagatose, polyols (e.g., sorbitol, mannitol, xylitol, lactitol, erythritol, and maltitol), hydrogenated starch hydrolysates, isomalt, trehalose, and combinations thereof.
- polyols e.g., sorbitol, mannitol, xylitol, lactitol, erythritol, and maltitol
- hydrogenated starch hydrolysates isomalt,
- the suitable excipient is a pharmaceutically acceptable excipient.
- the present invention further provides for a food preparation, a dietary or food supplement, a nutraceutical, a beverage, a medicament and a topical preparation comprising the composition of the present invention.
- the dietary supplement, the nutraceutical or the medicament of the present invention is administered at a dosage of between 5 mg per day to 2'000 mg per day. Preferably between 50 mg to 1'000 mg per day and even more preferably between 100 mg to 400 mg per day.
- the preparation, the dietary supplement, the nutraceutical or the medicament of the present invention can be administered orally, parenterally or topically at a dosage of between 5 mg per day to 2'000 mg per day. Preferably between 50 mg to 1'000 mg per day and more preferably between 100 mg to 400 mg per day.
- the medicament of the present invention can be in the form, for example, of a tablet, a caplet, a pill, a hard or soft capsule, a lozenge, a cachet, a dispensable powder, granules, a suspension, an elixir, a dispersion, a liquid, or any other form reasonably adapted for such administration.
- parenteral administration it can be in the form, for example, of a solution for intravenous, intramuscular or subcutaneous injection.
- the topical preparations according to the present invention can be, but not limited to, a cream, a patch, a gel, an ointment, a lotion, a tincture, a spray, a mousse, a cleansing composition or a foam.
- the topical preparations of the present invention can be also in the form of a suspension or dispersion in solvents or fatty substances, or alternatively in the form of an emulsion or micro emulsion, PET-emulsions, multiple emulsions, bickering emulsions, hydrogels, alcoholic gels, lipogels, one or multiphase solutions or a vesicular dispersion and other usual compositions, which can also be applied by pens, as masks or as sprays.
- the emulsions can also contain anionic, nonionic, cationic or amphoteric surfactant(s).
- composition of the invention may be used in a food preparation, a dietary supplement, a medicament, a nutraceutical, or a beverage.
- composition or the medicament of the invention is administered orally, parenterally or topically as defined above.
- An oral administration of the blend in accordance with an administration regimen over a prolonged period of time provides certain benefits, which include helping to protect, restore and sustain blood vessel health and improve blood flow to the genital area, naturally enhancing male erections or female tumescence, naturally enhancing the body's sexual response and improving the health of the sexual vascular system.
- the blend or composition of the present invention may be in the form of a composition, taken either in tablet form or in liquid form.
- the blend may be in the form of the ingredients being in separate, distinct tablet or liquid form but packaged together in a kit. In the latter case, the separate ingredients are taken either simultaneously, such as by mixing them together if in liquid form, or one after another if in tablet form.
- the composition or the medicament of the invention is administered at a dosage of between 5 mg per day to 2'000 mg per day.
- the subject in need thereof is a mammal, preferably a human.
- the medicament or the dietary supplement of the invention is for example adapted for use in improving sexual fitness or wellness of both sexes, for use in improving man sexual enhancement such as sperm production or fertility and/or for use in treating or preventing sexual dysfunction in both sexes.
- composition is for example adapted for use in improving sexual fitness or wellness of both sexes, for use in improving man and female sexual enhancement and/or for use in treating or preventing sexual dysfunction in both sexes.
- a unit dosage comprises a therapeutically effective daily amount of the composition of the invention which may be taken as a single daily administration or by multiple small doses taken over the course of a day.
- kits comprising the composition of the invention.
- the female sexual function was used to assess sexual function in women. Women's sexual function is scored using the established "Female Sexual Function Index” (FSFI) questionnaire [ Rosen R, Blown C, Heiman J, Leiblum S, Meston CM, Shabsigh R, Ferguson D, D'Agostino R., Jr The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function. Journal of Sex & Marital Therapy. 2000;26:191-208 ].
- FSFI Female Sexual Function Index
- the questionnaire allows to score prevalence of six subcategories (domains) related to female sexual function, with minimum and maximum scores given: Desire 1.2 - 6 Arousal 0 - 6 Lubrication 0 - 6 Satisfaction 0.8 - 6 Pain 0 - 6 Orgasm 0 - 6
- QR extract has a dose-related efficacy in improving sexual function in women.
- the efficacy increased with the dosage.
- the individual six FSFI domains related to desire, arousal, lubrication, orgasm, satisfaction and pain did all respond favourably to treatment with QR and the improvement of the scores were related to the dosage.
- IIEF International Index of Erectile Function
- QR extract has a dose-related efficacy in improving sexual function in men.
- the efficacy increased with the dosage.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Medicines Containing Plant Substances (AREA)
Description
- The present invention relates to a composition consisting of ellagitannins rich extracts originating from plant extracts of the Fagaceae family, for use in a method for improving sexual fitness or wellness of both sexes, the male sexual enhancement, the treatment or prevention of sexual dysfunction in both sexes.
- When a male is in his early twenties, it's easy to take peak sexual performance for granted. Yet as time passes, the male body's biological system changes, and he may notice that his sexual stamina, performance and even pleasure begin to decrease. Getting "in the mood" may start to take a little effort.
Many women have problems with sex when they reach menopause and their ovaries produce smaller amounts of sex hormones. Lower levels of estrogen can make the vaginal tissue dry, and less androgen leads to less sexual desire and arousal.
One important difference affecting sexual desire is that men have levels of testosterone that are 20 to 30 times what women have. Men's testosterone levels gradually decline over time but they do not experience a drop-off as women do at menopause. In men and women, testosterone and other androgens work to increase desire. - Treatment with drugs, such as those used for hypertension and hyperlipidemia, may have negative effects on sexual function and interest. Vaginal dryness is progressively more frequent with age, and vaginal infections are more common with increasing age and in diabetic women. They may cause sexual dysfunction (SD), loss of interest, and difficult or painful intercourse that can be associated with anxiety and fear, contributing to a lack of motivation.
- The family Fagaceae, or beech family, comprises about 900 species of both evergreen and deciduous trees and shrubs, which are characterized by alternate simple leaves with pinnate venation, unisexual flowers in the form of catkins, and fruit in the form of cup-like (cupule) nuts. Fagaceous leaves are often lobed and both petioles and stipules are generally present. Fruits lack endosperm and lie in a scaly or spiny husk that may or may not enclose the entire nut, which may consist of one to seven seeds. The best-known group of this family is the oaks, genus Quercus, the fruit of which is a non-valved nut (usually containing one seed) called an acorn. The husk of the acorn in most oaks only forms a cup in which the nut sits.
- Several members of the Fagaceae have important economic uses. Many species of oak, chestnut, and beech (genera Quercus, Castanea, and Fagus respectively) are commonly used as timber for floors, furniture, cabinets, and wine barrels. Cork for stopping wine bottles and a myriad of other uses is made from the bark of cork oak, Quercus suber. Chestnuts, a tasty treat enjoyed by many in the winter, are the fruits from species of the genus Castanea. Numerous species from several genera are prominent ornamentals, and wood chips from the genus Fagus are often used in flavoring beers.
- There is still a need for an effective, natural and safe composition for improving sexual fitness or wellness of both sexes, the man sexual enhancement, the treatment of sexual dysfunction.
- In one aspect of the present invention there is provided a composition consisting of ellagitannins rich extracts originating from plant extracts of the Fagaceae family, wherein said extracts are natural extracts having more than 50% w/w of ellagitannins based on dried extract or having ellagitannins at a concentration of at least 10% of the total weight of said composition, for use in a method for the treatment or prevention of sexual dysfunction in both sexes.
- Another aspect of the invention resides in a composition that, when administered, offers both sex a safe, natural way to preserve and maintain sexual responsiveness, endurance and enjoyment. It includes a blend or composition consisting of ellagitannins rich extracts originated from plants of the Fagacaea family. When the blend is administered, or taken on a daily basis over a period of time, sexual fitness or sexual wellness improves by the end of the period of time.
- In another aspect, the present invention provides for an oral administration in the form of a dietary or food supplement, a food preparation, a beverage, a medicament or for a topical preparation comprising the composition of the present invention.
- In a further aspect, it is provided the use of a composition consisting of ellagitannins rich extracts originating from plant extracts of the Fagaceae family, wherein said extracts are natural extracts having more than 50% w/w of ellagitannins based on dried extract or having ellagitannins at a concentration of at least 10% of the total weight of said composition, for the improving of sexual fitness or wellness or the sexual enhancement in both sexes.
- Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described below. In addition, the materials, methods, and examples are illustrative only and are not intended to be limiting.
- In the case of conflict, the present specification, including definitions, will control.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of skill in art to which the subject matter herein belongs. As used herein, the following definitions are supplied in order to facilitate the understanding of the present invention. - The term "comprise" is generally used in the sense of include, that is to say permitting the presence of one or more features or components.
- As used in the specification and claims, the singular form "a", "an" and "the" include plural references unless the context clearly dictates otherwise.
- The term "extract", as used herein includes any preparation obtained from plants, fruits, roots or vegetables using an extraction method.
- The term "food preparation" refers generally to material of either plant or animal origin, or of synthetic sources, that contain essential nutrients such as a carbohydrate, protein, fat, vitamin, mineral, etc. used in the body of an organism to sustain growth, repair, and vital processes and to furnish energy.
- A "dietary or food supplement" refers to a product that contains substances like vitamins, minerals, foods, botanicals, amino acids and is intended to supplement the usual intake of these substances. Dietary supplements are found in pill, tablet, capsule, powder or liquid form and are meant to be taken by mouth.
- The term "nutraceutical" refers to any substance that is a food or a part of a food and provides medical or health benefits, including the prevention and treatment of disease. Such products may range from isolated nutrients, dietary supplements and specific diets to genetically engineered designer foods, herbal products, and processed foods such as cereals, soups and beverages. It also refers to a product isolated or purified from foods, and generally sold in medicinal forms not usually associated with food and demonstrated to have a physiological benefit or provide protection against diseases like chronic diseases for example.
- The term "beverage" means a liquid for drinking, which may be water, flavored water, soft drinks, alcoholic drink, health drink, or an enriched drink like based on a diary product (milk) or fruit juice.
- "Pharmaceutically acceptable excipients or carriers" are any materials that do not interfere with the pharmacological activity of the active ingredient(s) or degrade the body functions of the subject to which it can be administered but facilitate fabrication of dosage forms or administration of the composition. Examples of pharmaceutically acceptable excipient include but are not limited to maltodextrin, calcium phosphate, and fused silica. Pharmaceutically acceptable excipients also include flavorants, as well as various additives such as other vitamins and minerals, all solvents, dispersion media, coatings, isotonic and absorption delaying agents, sweeteners and the like, non-toxic auxiliary substances such as wetting or emulsifying agents, pH buffering agents and the like, such as for example, sodium acetate, sorbitan monolaurate, triethanolamine oleate, and inert ingredients such as talc and magnesium stearate which are standard excipients in the manufacture of tablets, capsules and other dosage forms.
- As used herein the terms "subject" or "patient" are well-recognized in the art, and, are used interchangeably herein to refer to a mammal, including dog, cat, rat, mouse, monkey, cow, horse, goat, sheep, pig, camel, and, most preferably, a human. In some embodiments, the subject is a subject in need of treatment or a subject with a disease or disorder. However, in other embodiments, the subject can be a normal subject. The term does not denote a particular age or sex. Thus, adult and newborn subjects, whether male or female, are intended to be covered.
- The term "an effective amount" refers to an amount necessary to obtain a physiological effect. The physiological effect may be achieved by one application dose or by repeated applications. The dosage administered may, of course, vary depending upon known factors, such as the physiological characteristics of the particular composition; the age, health and weight of the subject; the nature and extent of the symptoms; the kind of concurrent treatment; the frequency of treatment; and the effect desired and can be adjusted by a person skilled in the art.
- As used herein, the terms "prevention" and "preventing," when referring to a disorder or symptom, refers to a reduction in the risk or likelihood that a mammalian subject will develop said disorder, symptom, condition, or indicator after treatment according to the invention, or a reduction in the risk or likelihood that a mammalian subject will exhibit a recurrence of said disorder, symptom, condition, or indicator once a subject has been treated according to the invention and cured or restored to a normal state.
- As used herein, the terms "treatment" or "treating," when referring to sexual dysfunction, sexual fitness or wellness, sexual enhancement in both sexes, refers to inhibiting or reducing the progression, nature, or severity of the subject condition or delaying the onset of the condition.
- The present invention provides a composition consisting of ellagitannins rich extracts originating from plant extracts of the Fagaceae family, wherein said extracts are natural extracts having more than 50% w/w of ellagitannins based on dried extract or having ellagitannins at a concentration of at least 10% of the total weight of said composition, for use in a method for treating or preventing sexual dysfunction, as well as the use of said composition for improving sexual fitness or wellness, or for improving sexual enhancement in both sexes.
- Ellagitannins of the invention are originating from a plant extract or from a synthesized material.
Preferably said ellagitannins rich extracts originated from plant extracts of the Fagacaea family comprise Roburins or derivatives thereof as defined below.
Most preferably the plant extracts of the Fagacaea family consists of Quercus robur extracts as defined above. - Another aspect of the invention resides in a composition that, when administered, offers both sex a safe, natural way to preserve and maintain sexual responsiveness, endurance and enjoyment.
- Also encompassed by the present invention is a method for improving sexual fitness or wellness of both sexes comprising administering to a subject in need thereof an effective amount of the composition or the medicament of the invention.
- The invention also provides for a method for improving man and female sexual enhancement comprising administering to a subject in need thereof an effective amount of the composition or the medicament of the invention.
- The invention also concerns a method of treating or preventing sexual dysfunction in both sexes comprising administering to a subject in need thereof an effective amount of the preparation or the medicament according to the invention.
- The methods according to the invention enhance a level of sexual wellness for both sexes. The composition of the invention being in therapeutically effective amounts so that, when the composition is administered at least daily over a period of time, in a sufficient amount, it enhances a level of sexual wellness by an end of the period of time.
- The methods of the invention also help in attaining enhanced sexual wellness. The administering includes initially administering an elevated dosage of the composition of the invention to attain the enhanced level of sexual wellness by the end of the period of time and thereafter administering a dosage of the composition daily that contains less of the composition than the elevated dosage and still provide the enhanced level of sexual wellness.
- "Fitness", whether "sexual fitness" or physical fitness, is defined as a measure of efficient functioning. A person who is sexually fit is efficient in their capacity to think, feel, and behave in a sexual manner without shame, embarrassment, or hidden agendas of falsely boosting their ego or self-esteem. People who reach and practice this style of fitness are more likely to function efficiently in all aspects of their perceptual world. These fortunate individuals are more confident, physically ill less often, and manage stressful events more successfully. Sexual fitness is an achieved state of being allowing people to perform better in every action they engage in. Having this capability affords person to feel confident in all situations whether a partner is involved or not.
- "Sexual wellness" of both sexes is the active participation of the individual in his or her life by addressing the numerous issues within sexual health. The process defined as sexual wellness is to improved sexual health. "Sexual health" is a state of physical, mental and social well-being in relation to sexuality. It requires a positive and respectful approach to sexuality and sexual relationships, as well as the possibility of having pleasurable and safe sexual experiences, free of coercion, discrimination and violence (definition WHO 2002). In particular, Sexual health is the integration of the somatic, emotional, intellectual, and social aspects of sexual being, in ways that are positively enriching and that enhance personality, communication, and love.
Fundamental to this concept are the right to sexual information and the right to pleasure (definition of WHO 1975). Sexual health is inextricably bound to both physical and mental health. - "Male sexual enhancement" may be defined as the increase of the hardness of erection; the improvement of self-confidence; the improvement of sperm quality, count and motility (spontaneous motion) and fertility; the increase of libido and sex drive; the boosting of the sexual energy level and vitality; the improvement of sexual performance problems i.e. those due to aging as well as the increase of energy and the greater sexual satisfaction with a partner. Men's sexual function is scored using the established "International Index of Erectile Function" (IIEF) questionnaire [Rosen et al., Urology. 1997 Jun;49(6):822-30.The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction], see i.e. example 4. http://www.seekwellness.com/mensexuality/questionnaire.htm
- "Female sexual enhancement" is defined as anything that enhances a woman's sexuality; this includes in particular the increase of libido or sex drive. Low libido or sex drive in women can be caused by a number of factors that vary from one woman to another; fatigue, mild depression, and the multiple roles that women play in daily life can cause psychological issues, which can have an affect on a woman's sexual appetite. Antidepressants, birth control, tranquilizers and mood stabilizers also impact sexual activity and other conditions like diabetes, heart disease and a poor diet can also reduce a woman's sex drive. Woman's sexuality level may be determined by the Female Sexual Function Index (FSFI) and the Women's Health Questionnaire (WHQ) which are defined and detailed in example 4.
- "Sexual dysfunction" or sexual malfunction in both sexes refers to a difficulty experienced by an individual or a couple during any stage of a normal sexual activity, including desire, arousal or orgasm. Sexual desire disorders or decreased libido are characterized by a lack or absence for some period of time of sexual desire or libido for sexual activity or of sexual fantasies. Sexual arousal disorders were previously known as frigidity in women and impotence in men, though these have now been replaced with less judgmental terms. Impotence is now known as erectile dysfunction, and frigidity has been replaced with a number of terms describing specific problems with, for example, desire or arousal. For both men and women, these conditions can manifest themselves as an aversion to, and avoidance of, sexual contact with a partner. In men, there may be partial or complete failure to attain or maintain an erection, or a lack of sexual excitement and pleasure in sexual activity.
- "Erectile dysfunction" or impotence is a sexual dysfunction characterized by the inability to develop or maintain an erection of the penis. The causes of erectile dysfunction may be psychological or physical.
- Orgasm disorders are persistent delays or absence of orgasm following a normal sexual excitement phase. The disorder can have physical, psychological, or pharmacological origins.
- Sexual pain disorders affect women almost exclusively and are known as dyspareunia (painful intercourse) or vaginismus (an involuntary spasm of the muscles of the vaginal wall that interferes with intercourse).
- While drugs for sexual enhancement may offer a temporary solution or tempting "quick fix," they are associated with unwanted side effects and can be expensive. The blend/composition according to the present invention, which is a natural dietary supplement, offers a safe, natural and cost-effective alternative.
- Those plant extracts of the composition according to the present invention are also referred as "ellagitannins rich extracts".
The ellagitannins are a diverse class of hydrolyzable tannins, a type of polyphenol formed primarily from the oxidative linkage of galloyl groups in 1,2,3,4,6-Pentagalloyl glucose. Ellagitannins differ from gallotannins, in that their galloyl groups are linked through C-C bonds, whereas the galloyl groups in gallotannins are linked by depside bonds. Ellagitannins comprise (Roburins A, B, C, D, E, Vescalin, Castalin, Vescalagin, Castalagin). - Preferably said ellagitannins rich extracts originated from plant extracts of the Fagacaea family comprise Roburins or derivatives thereof. Roburins include Roburins A, B, C, D, E In the present invention the term "Roburins" will be considered as equivalent to Roburins A, B, C, D, E and are interchangeable.
- Roburin A is a tannin found for example in oak wood (Quercus robur and Quercus petraea or Quercus alba) or oak cork (Quercus suber). It is a dimeric compound, composed of two vescalagin subunits probably linked through an ether bond between the diphenoyl group of one subunit and the triphenoyl moiety of the other one.
- Preferably the plant extracts of the Fagacaea family are selected among genera Quercus, Castanea, and Fagus or mixtures thereof. Among the Fagaceae, particularly worthy of mention are the Fagus grandifolia, common beech (Fagus sylvatica), sweet chestnut (Castanea sativa) and English oak (Quercus robur).
Most preferably, the plant extracts of the Fagacaea family consists of oak woods extracts. Even more preferably, the plant extracts of the Fagacaea family consists of Quercus robur extracts. - "Quercus robur" also known as "oak wood" belongs to the family of Fagaceae and the genus Quercus. Quercus robur (sometimes considered Q. pedunculata) is commonly known as Pedunculate oak or English oak. Also included in this definition of "oak wood" is the white oak, Quercus alba, Quercus brutia Tenore, Q. pedunculiflora, Q. haas as well as the Sessile Oak (Q. petraea). In the present invention the term "Quercus robur" will be considered as equivalent to oak wood as defined above, they are interchangeable.
Gathering: felling of the trees under National Forest Office control, from October to April when the sap is down. Oak wood is traditionally used to make wine barrels and is known to give its taste to wine and to contribute to its antioxidant activity. Fresh wood chips used for Biolandes extract are purchased from a famous wine barrel maker (http://www.dargaud-jaegle.com/) and obtained from Oak trees rigorously selected.
The extraction process is carried out by water extraction at low temperature (50°C) and spray drying. No petrochemical solvent is used.
Oak wood extract contains ellagitannins (Roburins A, B, C, D, E, Vescalin, Castalin, Vescalagin, Castalagin) and phenolic acids (gallic acid, ellagic acid). - The composition consisting of ellagitannins, present in the preparation of the invention, is originating from a plant extract or alternatively from a synthesized material (i.e., synthetic ellagitannins, i.e. roburins).
- Ellagitannins containing rich extracts are natural and preferably plant extracts having more than 50% by weight (of dried extracts) of ellagitannins (in particular roburins), more preferably more than 70% by weight and even more preferably more than 75% by weight of ellagitannins (in particular roburins). Preferably the plant extract according to the present invention is originated from oak wood extracts and more preferably the plant extract is Quercus robur.
- In a preferred embodiment, the composition may contain ellagitannins (in particular roburins) at a concentration of 10% to 100% of total weight. For example, the composition of the invention may be diluted or concentrated to contain 10%, 20%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 90% or 95% ellagitannins (in particular roburins). Concentration may be performed using known methods such as column chromatography or affinity chromatography.
- The composition of the invention may further comprise vitamins, coenzymes, mineral substances, aminoacids and antioxidants and/or a suitable excipient q.s.p. The composition may be manufactured in the form of tablets, lozenges, capsules, pills, granulates, syrups, vials or drops.
- The suitable excipient of the invention is an acceptable excipient or carrier as defined above. Examples of suitable excipients of this invention include, but are not limited to, anti-adherents, binders (e.g., macrocrystalline cellulose, gum tragacanth, or gelatin), coatings, disintegrants, fillers, diluents, softeners, emulsifiers, flavoring agents, coloring agents, adjuvants, lubricants, functional agents (e.g., nutrients), viscosity modifiers, bulking agents, glidiants (e.g., colloidal silicon dioxide) surface active agents, osmotic agents, diluents, or any other non-active ingredient, or combinations thereof.
- For example, the composition of the present invention may further include excipient materials selected from the group consisting of calcium carbonate, coloring agents, whiteners, preservatives, and flavors, triacetin, magnesium stearate, sterotes, natural or artificial flavors, essential oils, plant extracts, fruit essences, gelatins, or combinations thereof.
- Optionally the composition of the present invention may include other artificial or natural sweeteners, bulk sweeteners, or combinations thereof. Bulk sweeteners include both caloric and non-caloric compounds. Non-limiting examples of bulk sweeteners include sucrose, dextrose, maltose, dextrin, dried invert sugar, fructose, high fructose corn syrup, levulose, galactose, corn syrup solids, tagatose, polyols (e.g., sorbitol, mannitol, xylitol, lactitol, erythritol, and maltitol), hydrogenated starch hydrolysates, isomalt, trehalose, and combinations thereof.
- In a preferred embodiment of the invention, the suitable excipient is a pharmaceutically acceptable excipient.
- The present invention further provides for a food preparation, a dietary or food supplement, a nutraceutical, a beverage, a medicament and a topical preparation comprising the composition of the present invention.
- Preferably, the dietary supplement, the nutraceutical or the medicament of the present invention is administered at a dosage of between 5 mg per day to 2'000 mg per day. Preferably between 50 mg to 1'000 mg per day and even more preferably between 100 mg to 400 mg per day.
- The preparation, the dietary supplement, the nutraceutical or the medicament of the present invention can be administered orally, parenterally or topically at a dosage of between 5 mg per day to 2'000 mg per day. Preferably between 50 mg to 1'000 mg per day and more preferably between 100 mg to 400 mg per day.
- If intended for oral administration, the medicament of the present invention can be in the form, for example, of a tablet, a caplet, a pill, a hard or soft capsule, a lozenge, a cachet, a dispensable powder, granules, a suspension, an elixir, a dispersion, a liquid, or any other form reasonably adapted for such administration. If intended for parenteral administration, it can be in the form, for example, of a solution for intravenous, intramuscular or subcutaneous injection.
- The topical preparations according to the present invention can be, but not limited to, a cream, a patch, a gel, an ointment, a lotion, a tincture, a spray, a mousse, a cleansing composition or a foam. The topical preparations of the present invention can be also in the form of a suspension or dispersion in solvents or fatty substances, or alternatively in the form of an emulsion or micro emulsion, PET-emulsions, multiple emulsions, bickering emulsions, hydrogels, alcoholic gels, lipogels, one or multiphase solutions or a vesicular dispersion and other usual compositions, which can also be applied by pens, as masks or as sprays. The emulsions can also contain anionic, nonionic, cationic or amphoteric surfactant(s).
- The composition of the invention may be used in a food preparation, a dietary supplement, a medicament, a nutraceutical, or a beverage.
- Preferably, the composition or the medicament of the invention is administered orally, parenterally or topically as defined above.
- An oral administration of the blend in accordance with an administration regimen over a prolonged period of time provides certain benefits, which include helping to protect, restore and sustain blood vessel health and improve blood flow to the genital area, naturally enhancing male erections or female tumescence, naturally enhancing the body's sexual response and improving the health of the sexual vascular system.
- By orally administering the composition of the invention, the benefits to sexual fitness or sexual wellness are realized. That is, over time, the cumulative effect of the blend leaves one experiencing a heightened sense of sexual well-being.
The blend or composition of the present invention may be in the form of a composition, taken either in tablet form or in liquid form. Alternatively, the blend may be in the form of the ingredients being in separate, distinct tablet or liquid form but packaged together in a kit. In the latter case, the separate ingredients are taken either simultaneously, such as by mixing them together if in liquid form, or one after another if in tablet form. - In one embodiment of the invention, the composition or the medicament of the invention is administered at a dosage of between 5 mg per day to 2'000 mg per day. The subject in need thereof is a mammal, preferably a human.
- The medicament or the dietary supplement of the invention is for example adapted for use in improving sexual fitness or wellness of both sexes, for use in improving man sexual enhancement such as sperm production or fertility and/or for use in treating or preventing sexual dysfunction in both sexes.
- The latter composition is for example adapted for use in improving sexual fitness or wellness of both sexes, for use in improving man and female sexual enhancement and/or for use in treating or preventing sexual dysfunction in both sexes.
- A unit dosage comprises a therapeutically effective daily amount of the composition of the invention which may be taken as a single daily administration or by multiple small doses taken over the course of a day.
- Also encompassed is a kit comprising the composition of the invention.
- Those skilled in the art will appreciate that the invention described herein is susceptible to variations and modifications other than those specifically described. It is to be understood that the invention includes all such variations and modifications without departing from the spirit or essential characteristics thereof. The invention also includes all of the steps, features, compositions and compounds referred to or indicated in this specification, individually or collectively, and any and all combinations or any two or more of said steps or features. The present disclosure is therefore to be considered as in all aspects illustrated and not restrictive, the scope of the invention being indicated by the appended Claims, and all changes which come within the meaning and range of equivalency are intended to be embraced therein.
- The foregoing description will be more fully understood with reference to the following Examples. Such Examples, are, however, exemplary of methods of practising the present invention and are not intended to limit the scope of the invention.
- The female sexual function was used to assess sexual function in women. Women's sexual function is scored using the established "Female Sexual Function Index" (FSFI) questionnaire [ Rosen R, Blown C, Heiman J, Leiblum S, Meston CM, Shabsigh R, Ferguson D, D'Agostino R., Jr The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function. Journal of Sex & Marital Therapy. 2000;26:191-208 ].
The questionnaire allows to score prevalence of six subcategories (domains) related to female sexual function, with minimum and maximum scores given:Desire 1.2 - 6 Arousal 0 - 6 Lubrication 0 - 6 Satisfaction 0.8 - 6 Pain 0 - 6 Orgasm 0 - 6 - Adult women of all ages were investigated who presented with a score lower than four points out of maximum six points for all six domains.
- The investigation depicts the number of responders to the intervention as detailed in table 8 after four week treatment with a score equal to or higher than four points for all six domains.
Table 8 Dosage of QR extract Number of women responding Total number of women investigated 0 mg 0 22 50 mg 5 23 100 mg 11 24 200 mg 16 22 300 mg 21 25 - The results show that QR extract has a dose-related efficacy in improving sexual function in women. The efficacy increased with the dosage.
In addition it was observed that the individual six FSFI domains related to desire, arousal, lubrication, orgasm, satisfaction and pain did all respond favourably to treatment with QR and the improvement of the scores were related to the dosage. - Men's sexual function is scored using the established "International Index of Erectile Function" (IIEF) questionnaire [Rosen et al., Urology. 1997 Jun;49(6):822-30. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfuncti on]. A subset of only 6 questions (#1-5 plus 15) of the total 30 questions is related to erectile function with values ranging from minimum zero to 30.
IIEF scores range from [0-30]. - Men entering the study are having moderate erectile problems at baseline with values 13-18 and after treatment achieving sufficient erectile abilities (values of 19 and above). Treatment duration was 2 weeks.
- Number of men responding with IIEF ≥ 19 at different QR extract dosages taken for two weeks:
Table 9 Dosage of QR extract Number of men responding with IIEF ≥ 19 Total number of men investigated 0 mg 0 23 50 mg 6 25 100 mg 10 22 200 mg 15 22 300 mg 20 26 - The results show that QR extract has a dose-related efficacy in improving sexual function in men. The efficacy increased with the dosage.
- In parallel to the increase of erectile function, the number or intercourse increased significantly. The detailed IIEF scores for orgasmic function, sexual desire, intercourse satisfaction and overall satisfaction were significantly increased.
Claims (12)
- A composition consisting of ellagitannins rich extracts originating from plant extracts of the Fagaceae family, wherein said extracts are natural extracts having more than 50% w/w of ellagitannins based on dried extract or having ellagitannins at a concentration of at least 10% of the total weight of said composition, for use in a method for treating or preventing sexual dysfunction in both sexes.
- The composition for use according to claim 1, wherein said ellagitannins rich extracts originate from plant extracts of the Fagacaea family comprise Roburins or derivatives thereof.
- The composition for use of claims 1 or 2, wherein the plant extracts of the Fagacaea family are selected among genera Quercus, Castanea, and Fagus or mixtures thereof.
- The composition for use of claim 3, wherein the plant extracts of the Fagacaea family consists of oak woods extracts.
- The composition for use of claim 4, wherein the plant extracts of the Fagacaea family consists of Quercus robur extracts.
- The composition for use of anyone of claims 1 to 5, wherein the composition is adapted for an oral administration.
- The composition for use according to claim 6, wherein the oral administration is in the form of a food preparation, a dietary supplement, a nutraceutical, or a beverage.
- The use of a composition consisting of ellagitannins rich extracts originating from plant extracts of the Fagaceae family, wherein said extracts are natural extracts having more than 50% w/w of ellagitannins based on dried extract or having ellagitannins at a concentration of at least 10% of the total weight of said composition, for the improving of sexual fitness or wellness or the sexual enhancement in both sexes.
- The use according to claim 8, characterized in that said ellagitannins rich extracts originate from plant extracts of the Fagacaea family comprise Roburins or derivatives thereof.
- The use according to claims 8 or 9, characterized in that the plant extracts of the Fagacaea family are selected among genera Quercus, Castanea, and Fagus or mixtures thereof.
- The use according to any one of claims 8-10, wherein the plant extracts of the Fagacaea family consists of oak woods extracts.
- The use according to any one of claims 8-11, wherein the plant extracts of the Fagacaea family consists of Quercus robur extracts.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI201230634A SI2793905T1 (en) | 2011-12-23 | 2012-12-21 | Ellagitannins rich extracts composition in sexual wellness |
HRP20160758TT HRP20160758T1 (en) | 2011-12-23 | 2016-06-28 | Ellagitannins rich extracts composition in sexual wellness |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH20452011 | 2011-12-23 | ||
PCT/EP2012/076837 WO2013093096A1 (en) | 2011-12-23 | 2012-12-21 | Ellagitannins rich extracts composition in sexual wellness |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2793905A1 EP2793905A1 (en) | 2014-10-29 |
EP2793905B1 true EP2793905B1 (en) | 2016-04-06 |
Family
ID=47557106
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12816068.6A Active EP2793905B1 (en) | 2011-12-23 | 2012-12-21 | Ellagitannins rich extracts composition in sexual wellness |
EP12813867.4A Active EP2800572B1 (en) | 2011-12-23 | 2012-12-21 | Ellagitannins rich extracts composition |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12813867.4A Active EP2800572B1 (en) | 2011-12-23 | 2012-12-21 | Ellagitannins rich extracts composition |
Country Status (15)
Country | Link |
---|---|
US (2) | US9066924B2 (en) |
EP (2) | EP2793905B1 (en) |
JP (2) | JP5918389B2 (en) |
CN (2) | CN104053444B (en) |
BR (2) | BR112014015354A8 (en) |
CA (2) | CA2859066C (en) |
DK (2) | DK2793905T3 (en) |
HR (1) | HRP20160758T1 (en) |
PL (1) | PL2793905T3 (en) |
PT (1) | PT2793905E (en) |
SG (4) | SG10201602847XA (en) |
SI (1) | SI2793905T1 (en) |
TW (1) | TWI583390B (en) |
WO (2) | WO2013093096A1 (en) |
ZA (2) | ZA201403827B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4062921A1 (en) | 2021-03-25 | 2022-09-28 | Finthinktur Oy | Extract produced by means of a solvent and method for producing the extract |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10238684B2 (en) * | 2010-11-18 | 2019-03-26 | Foundational Biosystems, Llc | Micro- and nano-quantity sleep enhancing nutrient composition and method of enhancing central nervous system protein clearance using same |
FR3055215B1 (en) * | 2016-08-31 | 2020-02-14 | S.A.M. Serelys Pharma | COMPOSITION COMPRISING POLLEN AND / OR PISTILS EXTRACTS |
CN108041588A (en) * | 2017-12-08 | 2018-05-18 | 冯纪敏 | A kind of composition containing trehalose and its application |
CN112088010A (en) | 2018-05-04 | 2020-12-15 | 宝洁公司 | Compositions and methods for treating vaginal dryness |
EP3787659A1 (en) * | 2018-05-04 | 2021-03-10 | The Procter & Gamble Company | Compositions and methods for treating vaginal atrophy |
JP7185260B2 (en) * | 2018-06-18 | 2022-12-07 | 株式会社Active | Pharmaceutical compositions for treating nightmare disorders |
CN112236198A (en) * | 2018-06-29 | 2021-01-15 | 宝洁公司 | Vaginal care composition |
CN109287852B (en) * | 2018-09-18 | 2021-12-28 | 青岛农业大学 | Method for improving animal semen quality by using chestnut flower water extract |
KR102682981B1 (en) * | 2018-11-05 | 2024-07-11 | 마블바이옴 인코포레이티드 | Microbial compositions containing ellagitannins and methods of use |
IT202000004747A1 (en) * | 2020-03-06 | 2021-09-06 | A M Italy S R L | COMPOSITION FOR USE IN THERAPY, IN PARTICULAR FOR THE TREATMENT OF ANXIETY |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000136145A (en) * | 1998-10-29 | 2000-05-16 | Nikka Whisky Distilling Co Ltd | Extract of barrel material |
US8372454B2 (en) | 1999-04-19 | 2013-02-12 | Pom Wonderful Llc | Methods of making pomegranate compounds for the treatment of erectile dysfunction |
US20040247698A1 (en) | 2003-06-04 | 2004-12-09 | Valenzuela Cortes Carmen Maria | Erectile Dysfunction Treatment |
CN100566723C (en) * | 2004-09-13 | 2009-12-09 | 辻田隆广 | Carbohydrase inhibitor and application thereof derived from the acorn-cup plant |
JP2006104067A (en) * | 2004-09-30 | 2006-04-20 | Suntory Ltd | Aromatic composition having activity of adjusting autonomic nerve function and use of the same |
JP4778813B2 (en) * | 2006-03-07 | 2011-09-21 | 株式会社ロッテ | Methioninase inhibitor |
US20110105421A1 (en) * | 2008-03-14 | 2011-05-05 | The Florida International University Board Of Trustees | Ellagitannins as inhibitors of bacterial quorum sensing |
MX2012015059A (en) * | 2010-06-25 | 2013-04-03 | Horphag Res Ip Pre Ltd | Composition for improving sexual wellness. |
-
2012
- 2012-12-21 BR BR112014015354A patent/BR112014015354A8/en not_active Application Discontinuation
- 2012-12-21 DK DK12816068.6T patent/DK2793905T3/en active
- 2012-12-21 WO PCT/EP2012/076837 patent/WO2013093096A1/en active Application Filing
- 2012-12-21 CN CN201280064146.1A patent/CN104053444B/en not_active Expired - Fee Related
- 2012-12-21 DK DK12813867.4T patent/DK2800572T3/en active
- 2012-12-21 SI SI201230634A patent/SI2793905T1/en unknown
- 2012-12-21 SG SG10201602847XA patent/SG10201602847XA/en unknown
- 2012-12-21 BR BR112014015358A patent/BR112014015358A2/en not_active Application Discontinuation
- 2012-12-21 US US14/366,386 patent/US9066924B2/en active Active
- 2012-12-21 US US14/366,385 patent/US9060999B2/en active Active
- 2012-12-21 EP EP12816068.6A patent/EP2793905B1/en active Active
- 2012-12-21 PT PT128160686T patent/PT2793905E/en unknown
- 2012-12-21 WO PCT/EP2012/076845 patent/WO2013093102A1/en active Application Filing
- 2012-12-21 JP JP2014548104A patent/JP5918389B2/en active Active
- 2012-12-21 SG SG10201602856YA patent/SG10201602856YA/en unknown
- 2012-12-21 SG SG11201403425WA patent/SG11201403425WA/en unknown
- 2012-12-21 JP JP2014548102A patent/JP2015502170A/en active Pending
- 2012-12-21 EP EP12813867.4A patent/EP2800572B1/en active Active
- 2012-12-21 SG SG11201403431WA patent/SG11201403431WA/en unknown
- 2012-12-21 CA CA2859066A patent/CA2859066C/en active Active
- 2012-12-21 CA CA2859062A patent/CA2859062C/en active Active
- 2012-12-21 PL PL12816068.6T patent/PL2793905T3/en unknown
- 2012-12-21 CN CN201280064191.7A patent/CN104271141B/en active Active
- 2012-12-22 TW TW101149294A patent/TWI583390B/en active
-
2014
- 2014-05-26 ZA ZA2014/03827A patent/ZA201403827B/en unknown
- 2014-06-02 ZA ZA2014/04005A patent/ZA201404005B/en unknown
-
2016
- 2016-06-28 HR HRP20160758TT patent/HRP20160758T1/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4062921A1 (en) | 2021-03-25 | 2022-09-28 | Finthinktur Oy | Extract produced by means of a solvent and method for producing the extract |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2793905B1 (en) | Ellagitannins rich extracts composition in sexual wellness | |
US9028890B2 (en) | Composition for improving sexual wellness | |
RU2573990C2 (en) | Preparation, containing amino acids and plants, and its activity in alcohol detoxication | |
KR101498780B1 (en) | Composition for preventing or treating hangover | |
WO2008007227A2 (en) | Method and compositions for relieving menopausal and perimenopausal symptoms | |
KR102127703B1 (en) | Composition for preventing, improving or depression or anxiety comprising tart cherry extract and fermented rice germ extract | |
KR20100129571A (en) | Functional composition for improvement of sex and food having the same | |
KR100392876B1 (en) | A drink for eliminating a hangover and a method for producing the same | |
KR102235563B1 (en) | Composition for fatigue recovery and sexual function improvement containing high content of arginine | |
KR102135295B1 (en) | Composition for improving muscular endurance comprising extract of Ishige sinicola | |
KR102045847B1 (en) | Kyung-ok-go having high acceptability and anti-diabetes activity adding the silk of zea mays and pumpkin | |
KR20200044766A (en) | Composition for improving stress or depression comprising extract of Ishige sinicola | |
ES2575736T3 (en) | Composition of extracts rich in ellagitannins for sexual well-being | |
KR20190066460A (en) | Pharmaceutical composition comprising the seed extracts of rambutan as an effective component for prevention or treatment of diabetes and health functional food comprising the same | |
KR102214565B1 (en) | Composition for eliminating hangover comprising protectin DX | |
KR101854762B1 (en) | Composition for preventing or treating of depression and anxiety comprising alternariol monomethyl ether | |
WO2020116381A1 (en) | Blood flow improvement composition and vascular endothelium function improvement composition | |
KR20180002563A (en) | Agent for improvement of cathechin bioavailability |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20140723 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: HORPHAG RESEARCH IP (QR) LTD |
|
DAX | Request for extension of the european patent (deleted) | ||
17Q | First examination report despatched |
Effective date: 20150507 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
INTG | Intention to grant announced |
Effective date: 20151022 |
|
GRAS | Grant fee paid |
Free format text: ORIGINAL CODE: EPIDOSNIGR3 |
|
GRAA | (expected) grant |
Free format text: ORIGINAL CODE: 0009210 |
|
AK | Designated contracting states |
Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: FG4D |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: REF Ref document number: 786992 Country of ref document: AT Kind code of ref document: T Effective date: 20160415 Ref country code: CH Ref legal event code: EP |
|
REG | Reference to a national code |
Ref country code: IE Ref legal event code: FG4D |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R096 Ref document number: 602012016846 Country of ref document: DE |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: NV Representative=s name: KATZAROV S.A., CH |
|
REG | Reference to a national code |
Ref country code: PT Ref legal event code: SC4A Free format text: AVAILABILITY OF NATIONAL TRANSLATION Effective date: 20160614 |
|
REG | Reference to a national code |
Ref country code: HR Ref legal event code: TUEP Ref document number: P20160758 Country of ref document: HR |
|
REG | Reference to a national code |
Ref country code: ES Ref legal event code: FG2A Ref document number: 2575736 Country of ref document: ES Kind code of ref document: T3 Effective date: 20160630 |
|
REG | Reference to a national code |
Ref country code: RO Ref legal event code: EPE |
|
REG | Reference to a national code |
Ref country code: NL Ref legal event code: FP |
|
REG | Reference to a national code |
Ref country code: SE Ref legal event code: TRGR |
|
REG | Reference to a national code |
Ref country code: DK Ref legal event code: T3 Effective date: 20160722 |
|
REG | Reference to a national code |
Ref country code: LT Ref legal event code: MG4D |
|
REG | Reference to a national code |
Ref country code: HR Ref legal event code: T1PR Ref document number: P20160758 Country of ref document: HR |
|
REG | Reference to a national code |
Ref country code: NO Ref legal event code: T2 Effective date: 20160406 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 5 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LT Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160406 Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160806 |
|
REG | Reference to a national code |
Ref country code: SK Ref legal event code: T3 Ref document number: E 21297 Country of ref document: SK |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LV Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160406 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160707 Ref country code: RS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160406 |
|
REG | Reference to a national code |
Ref country code: DE Ref legal event code: R097 Ref document number: 602012016846 Country of ref document: DE |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: EE Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160406 |
|
PLBE | No opposition filed within time limit |
Free format text: ORIGINAL CODE: 0009261 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: SM Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160406 |
|
26N | No opposition filed |
Effective date: 20170110 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160406 |
|
REG | Reference to a national code |
Ref country code: FR Ref legal event code: PLFP Year of fee payment: 6 |
|
REG | Reference to a national code |
Ref country code: AT Ref legal event code: UEP Ref document number: 786992 Country of ref document: AT Kind code of ref document: T Effective date: 20160406 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PCAR Free format text: NEW ADDRESS: AVENUE DES MORGINES 12, 1213 PETIT-LANCY (CH) |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20121221 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160406 Ref country code: MK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160406 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: MT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20161221 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: AL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160406 |
|
REG | Reference to a national code |
Ref country code: HR Ref legal event code: ODRP Ref document number: P20160758 Country of ref document: HR Payment date: 20181205 Year of fee payment: 7 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: NO Payment date: 20181213 Year of fee payment: 7 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: BG Payment date: 20181214 Year of fee payment: 7 |
|
REG | Reference to a national code |
Ref country code: HR Ref legal event code: ODRP Ref document number: P20160758 Country of ref document: HR Payment date: 20191202 Year of fee payment: 8 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20160406 |
|
REG | Reference to a national code |
Ref country code: NO Ref legal event code: MMEP |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: RO Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20191221 |
|
REG | Reference to a national code |
Ref country code: CH Ref legal event code: PL |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: IE Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20191221 Ref country code: PT Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20200723 Ref country code: LU Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20191221 Ref country code: NO Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20191231 |
|
PG25 | Lapsed in a contracting state [announced via postgrant information from national office to epo] |
Ref country code: LI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20191231 Ref country code: SI Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20191222 Ref country code: BG Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20200630 Ref country code: CH Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES Effective date: 20191231 |
|
REG | Reference to a national code |
Ref country code: SI Ref legal event code: KO00 Effective date: 20201015 |
|
REG | Reference to a national code |
Ref country code: HR Ref legal event code: ODRP Ref document number: P20160758 Country of ref document: HR Payment date: 20201123 Year of fee payment: 9 |
|
REG | Reference to a national code |
Ref country code: HR Ref legal event code: ODRP Ref document number: P20160758 Country of ref document: HR Payment date: 20211102 Year of fee payment: 10 |
|
REG | Reference to a national code |
Ref country code: HR Ref legal event code: ODRP Ref document number: P20160758 Country of ref document: HR Payment date: 20221221 Year of fee payment: 11 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: IT Payment date: 20221122 Year of fee payment: 11 |
|
P01 | Opt-out of the competence of the unified patent court (upc) registered |
Effective date: 20230522 |
|
REG | Reference to a national code |
Ref country code: HR Ref legal event code: ODRP Ref document number: P20160758 Country of ref document: HR Payment date: 20231130 Year of fee payment: 12 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: NL Payment date: 20231121 Year of fee payment: 12 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: SK Payment date: 20231128 Year of fee payment: 12 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: GB Payment date: 20231124 Year of fee payment: 12 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: SE Payment date: 20231121 Year of fee payment: 12 Ref country code: HR Payment date: 20231130 Year of fee payment: 12 Ref country code: FR Payment date: 20231122 Year of fee payment: 12 Ref country code: FI Payment date: 20231121 Year of fee payment: 12 Ref country code: DK Payment date: 20231121 Year of fee payment: 12 Ref country code: DE Payment date: 20231121 Year of fee payment: 12 Ref country code: CZ Payment date: 20231124 Year of fee payment: 12 Ref country code: AT Payment date: 20231123 Year of fee payment: 12 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: PL Payment date: 20231127 Year of fee payment: 12 Ref country code: BE Payment date: 20231121 Year of fee payment: 12 |
|
REG | Reference to a national code |
Ref country code: BE Ref legal event code: PD Owner name: HORPHAG RESEARCH IP LTD.; CY Free format text: DETAILS ASSIGNMENT: CHANGE OF OWNER(S), MERGE; FORMER OWNER NAME: HORPHAG RESEARCH IP (QR) LTD Effective date: 20240306 |
|
PGFP | Annual fee paid to national office [announced via postgrant information from national office to epo] |
Ref country code: ES Payment date: 20240102 Year of fee payment: 12 |
|
REG | Reference to a national code |
Ref country code: GB Ref legal event code: 732E Free format text: REGISTERED BETWEEN 20240628 AND 20240703 |