EP2773336A4 - METHOD FOR THE TREATMENT OF HYPERURICEMIA IN PATIENTS WITH A HALOFENAT OR HALOFIC ACID GALILEY AND A SECOND URATIVE DECORATION MEDIUM - Google Patents

METHOD FOR THE TREATMENT OF HYPERURICEMIA IN PATIENTS WITH A HALOFENAT OR HALOFIC ACID GALILEY AND A SECOND URATIVE DECORATION MEDIUM

Info

Publication number
EP2773336A4
EP2773336A4 EP11875114.8A EP11875114A EP2773336A4 EP 2773336 A4 EP2773336 A4 EP 2773336A4 EP 11875114 A EP11875114 A EP 11875114A EP 2773336 A4 EP2773336 A4 EP 2773336A4
Authority
EP
European Patent Office
Prior art keywords
uratic
halofenate
dropping
patients
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP11875114.8A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP2773336A1 (en
Inventor
Brian K Roberts
Gopal Chandra Saha
Brian Edward Lavan
Charles A Mcwherter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diatex Inc
CymaBay Therapeutics Inc
Original Assignee
Metabolex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolex Inc filed Critical Metabolex Inc
Publication of EP2773336A1 publication Critical patent/EP2773336A1/en
Publication of EP2773336A4 publication Critical patent/EP2773336A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP11875114.8A 2011-11-04 2011-11-04 METHOD FOR THE TREATMENT OF HYPERURICEMIA IN PATIENTS WITH A HALOFENAT OR HALOFIC ACID GALILEY AND A SECOND URATIVE DECORATION MEDIUM Withdrawn EP2773336A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2011/059394 WO2013066349A1 (en) 2011-11-04 2011-11-04 Methods for treating hyperuricemia in patients with gout using halofenate or halofenic acid and a second urate-lowering agent

Publications (2)

Publication Number Publication Date
EP2773336A1 EP2773336A1 (en) 2014-09-10
EP2773336A4 true EP2773336A4 (en) 2015-06-03

Family

ID=48192533

Family Applications (1)

Application Number Title Priority Date Filing Date
EP11875114.8A Withdrawn EP2773336A4 (en) 2011-11-04 2011-11-04 METHOD FOR THE TREATMENT OF HYPERURICEMIA IN PATIENTS WITH A HALOFENAT OR HALOFIC ACID GALILEY AND A SECOND URATIVE DECORATION MEDIUM

Country Status (13)

Country Link
EP (1) EP2773336A4 (https=)
JP (1) JP6202633B2 (https=)
KR (1) KR20140121383A (https=)
CN (2) CN109908124A (https=)
AU (1) AU2011380507B2 (https=)
CA (1) CA2859686C (https=)
CL (1) CL2014001155A1 (https=)
IL (1) IL232386A0 (https=)
MX (1) MX357507B (https=)
NZ (1) NZ624708A (https=)
SG (1) SG11201402032RA (https=)
WO (1) WO2013066349A1 (https=)
ZA (1) ZA201403575B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104602686A (zh) * 2012-04-13 2015-05-06 西玛贝医药公司 利用卤芬酯或卤芬酸以及抗炎剂治疗痛风患者中高尿酸血症的方法
TWI809304B (zh) 2014-12-01 2023-07-21 奥默羅斯公司 用於抑制術後眼睛炎性病況的抗炎和散瞳前房溶液
JP6368756B2 (ja) * 2016-10-20 2018-08-01 サイマベイ・セラピューティクス・インコーポレイテッドＣｙｍａＢａｙ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ハロフェナートまたはハロフェン酸および第２の尿酸低下薬を用いる痛風に罹っている患者の高尿酸血症の治療方法
CN108014108A (zh) * 2016-11-03 2018-05-11 江苏万邦生化医药股份有限公司 lesinurad或其医药上可接受的盐在制备治疗或预防库欣综合征的药物中的应用
US11446317B2 (en) 2017-10-26 2022-09-20 Otsuka Pharmaceutical Co., Ltd. Inositol phosphate-containing composition
JP2023525631A (ja) * 2020-03-15 2023-06-19 アレン ダビドフ ウイルス感染症及び健康上の影響の治療方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130172368A1 (en) * 2011-11-04 2013-07-04 Metabolex, Inc. Methods for Treating Hyperuricemia in Patients with Gout Using Halofenate or Halogenic Acid and A Second Urate-Lowering Agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262118B1 (en) * 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
US7576131B2 (en) * 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
WO2011032175A1 (en) * 2009-09-14 2011-03-17 Nuon Therapeutics, Inc. Combination formulations of tranilast and allopurinol and methods related thereto

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130172368A1 (en) * 2011-11-04 2013-07-04 Metabolex, Inc. Methods for Treating Hyperuricemia in Patients with Gout Using Halofenate or Halogenic Acid and A Second Urate-Lowering Agent

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "NCT01399008 on 2011_07_20: ClinicalTrials.gov Archive", 20 July 2011 (2011-07-20), XP055185403, Retrieved from the Internet <URL:https://clinicaltrials.gov/archive/NCT01399008/2011_07_20> [retrieved on 20150423] *
ANONYMOUS: "NCT01416402 on 2011_10_21: ClinicalTrials.gov Archive", 21 October 2011 (2011-10-21), XP055185406, Retrieved from the Internet <URL:https://clinicaltrials.gov/archive/NCT01416402/2011_10_21> [retrieved on 20150423] *
GOPAL C SAHA ET AL: "Arhalofenate, a Potential Novel Treatment for Hyperuricemia, with or without Metabolic Co-Morbidities, in Patients with Gout: Meta-Analysis of Urate Lowering in Four Phase 2 Studies in Type 2 Diabetes.", ARTHRITIS & RHEUMATISM, vol. 63, no. 10, Suppl. S, October 2011 (2011-10-01), pages S1014, XP055185501 *
HOWARD S SMITH ET AL: "Gout: Current Insights and Future Perspectives", JOURNAL OF PAIN, vol. 12, no. 11, 28 September 2011 (2011-09-28), pages 1113 - 1129, XP028334440, ISSN: 1526-5900, [retrieved on 20110704], DOI: 10.1016/J.JPAIN.2011.06.009 *
See also references of WO2013066349A1 *

Also Published As

Publication number Publication date
AU2011380507A1 (en) 2014-05-29
KR20140121383A (ko) 2014-10-15
JP6202633B2 (ja) 2017-09-27
MX2014005400A (es) 2015-02-12
WO2013066349A1 (en) 2013-05-10
IL232386A0 (en) 2014-06-30
CL2014001155A1 (es) 2015-01-16
CA2859686A1 (en) 2013-05-10
ZA201403575B (en) 2015-11-25
SG11201402032RA (en) 2014-09-26
CA2859686C (en) 2018-09-11
MX357507B (es) 2018-07-12
EP2773336A1 (en) 2014-09-10
CN109908124A (zh) 2019-06-21
NZ624708A (en) 2015-11-27
JP2014532758A (ja) 2014-12-08
AU2011380507B2 (en) 2017-06-15
CN104066427A (zh) 2014-09-24

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Owner name: CYMABAY THERAPEUTICS, INC.

Owner name: DIATEX, INC.

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