EP2741714A1 - Vis de fixation acétabulaire à verrouillage et leur combinaison avec une cupule acétabulaire pour hanche inversée - Google Patents
Vis de fixation acétabulaire à verrouillage et leur combinaison avec une cupule acétabulaire pour hanche inverséeInfo
- Publication number
- EP2741714A1 EP2741714A1 EP12824127.0A EP12824127A EP2741714A1 EP 2741714 A1 EP2741714 A1 EP 2741714A1 EP 12824127 A EP12824127 A EP 12824127A EP 2741714 A1 EP2741714 A1 EP 2741714A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- acetabular
- acetabular cup
- screw
- screws
- reverse hip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000988 bone and bone Anatomy 0.000 abstract description 11
- 238000005553 drilling Methods 0.000 abstract description 4
- 210000001624 hip Anatomy 0.000 description 19
- 238000003780 insertion Methods 0.000 description 7
- 230000037431 insertion Effects 0.000 description 7
- 210000004197 pelvis Anatomy 0.000 description 6
- 238000011882 arthroplasty Methods 0.000 description 4
- 238000004513 sizing Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 208000003076 Osteolysis Diseases 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 208000029791 lytic metastatic bone lesion Diseases 0.000 description 2
- 208000006386 Bone Resorption Diseases 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 241001417935 Platycephalidae Species 0.000 description 1
- 210000000588 acetabulum Anatomy 0.000 description 1
- 230000024279 bone resorption Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/34—Acetabular cups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
- A61B17/8052—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates immobilised relative to screws by interlocking form of the heads and plate holes, e.g. conical or threaded
- A61B17/8057—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates immobilised relative to screws by interlocking form of the heads and plate holes, e.g. conical or threaded the interlocking form comprising a thread
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/8605—Heads, i.e. proximal ends projecting from bone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30316—The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
- A61F2002/30329—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2002/30331—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements made by longitudinally pushing a protrusion into a complementarily-shaped recess, e.g. held by friction fit
- A61F2002/30332—Conically- or frustoconically-shaped protrusion and recess
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/34—Acetabular cups
- A61F2002/3401—Acetabular cups with radial apertures, e.g. radial bores for receiving fixation screws
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/34—Acetabular cups
- A61F2002/3445—Acetabular cups having a number of shells different from two
- A61F2002/3446—Single cups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/34—Acetabular cups
- A61F2002/348—Additional features
- A61F2002/3483—Additional features having a convex shape, e.g. hemispherical heads
Definitions
- the present invention relates generally to interlocking acetabular fixation screws and particularly relates to interlocking acetabular fixation screws for providing a solid fixation of an acetabular cup into a prepared acetabular cavity of a pelvis during a total hip arthroplasty.
- the invention has to do with a combination of a new reverse hip acetabular cup having a stem firmly affixed in the concave portion thereof and the interlocking acetabular fixation screws which are used to firmly affix the cup in the acetabular cavity.
- the interlocking acetabular fixation screws according to the present invention substantially depart from the conventional sizing of screws of the prior art, and in so doing provides an apparatus primarily developed for the purpose of providing a solid acetabular fixation means into the prepared acetabular cavity of the pelvis during a total hip arthroplasty, particularly in respect of securing the reverse hip acetabular cup of the invention.
- the present invention provides for a new interlocking acetabular fixation screw construction and sizing for providing cancellous screws to be solidly fixed to a reverse hip acetabular cup upon insertion into the prepared acetabular cavity of the pelvis during a total hip arthroplasty.
- the interlocking acetabular fixation screws of the present invention are designed for use in combination with a new reverse hip acetabular cup described in Published PCT Application No.
- the general purpose of the present invention is to provide a properly sized interlocking acetabular fixation screw and its combination with the new reverse hip acetabular cup.
- the present invention generally comprises specially designed interlocking cancellous screws that will be firmly locked into threaded holes in the acetabular cup.
- the number of the holes normally varies between three and seven and a surgeon may choose to use one or more than one screw to affix the cup to the acetabulum.
- the interlocking acetabular fixation screws are specifically designed for insertion into threaded screw holes or openings in the acetabular cup of the new reverse hip prosthesis described in the published PCT application referenced above. Said screws have a coarse thread spread over the length of the shank of the screw from the distal end of the screw to the head in order to provide optimal screw fixation in the cancellous bone of the pelvis.
- the screw head at the proximal end of the screw is tapered and has a fine locking threaded portion.
- the screw head preferably has a 12 degree taper and the taper angle can vary from 10 degrees to 15 degrees.
- the head tapers outwardly from the cancellous threads to the proximal end of the screw so that the proximal end of the head has a larger diameter than the end near the cancellous threads.
- the head at the proximal end of the interlocking acetabular fixation screw provides a hexagonal recess for insertion with a hexagonal screwdriver.
- the screw holes in the acetabular cup are also threaded in a tapered fashion to mate with the fine threads of the head of the interlocking acetabular fixation screw.
- the screw holes of the acetabular cup are also drilled at a specific angle of inclination in order to avoid interference of the drilling instruments, the screws and the screw driver with the central stem of the reverse hip acetabular cup. This feature of the invention also facilitates drilling of the bone and insertion and tightening of the screws.
- Fig. 1 is a partial section view of the reverse hip acetabular cup with an elevation of an interlocking acetabular fixation screw locked in the cup.
- FIG. 2 is an elevation view of the interlocking acetabular fixation screw.
- FIG. 3 is a perspective view of the reverse hip acetabular cup with threaded holes.
- FIG. 4 is a section view of the acetabular cup with two interlocking acetabular fixation screws locked therein, one screw being illustrated in section and the other in perspective elevation.
- the attached figures illustrate an interlocking acetabular fixation screw 10, which comprises a specially designed and sized interlocking cancellous screw that will be firmly screwed and locked into threaded, tapered acetabular screw holes or openings 1 in acetabular cup 9. Said screws having a course thread 2 over the length of the screw shank, for optimal screw fixation in the cancellous bone of the pelvis, and a fine locking threaded portion 3 on the screw head.
- the screw head is preferably cut with a 12 degree taper, but the taper angle can vary from 10 degrees to 15 degrees.
- the head 8 of the interlocking acetabular fixation screw 10 also provides a hexagonal recess 4 for insertion of a hexagonal screwdriver.
- the screw holes or openings in the acetabular cup are drilled at specific angles of inclination in order to avoid interference of the drilling instruments (i.e., the drill guide and/or the drill bit) with the central stem 7 of the acetabular cup 9.
- the screw 10 that is illustrated in perspective elevation is at a different angle relative to center line A-A than the screw 10 that is illustrated in section.
- the angles and locations of the screw holes have been selected so that the drill guide, drill bit, screws and screw driver will not touch the central stem 7 and the stem will not interfere with installation of the screws.
- the stem 7 will not interfere with a drill guide and/or a drill bit.
- the stem 7 will not interfere with placement of the screws or with the screw driver used to tighten the screws.
- the reverse hip acetabular cup 9 has a convex outer surface for secure attachment to an acetabular cavity. And the cup 9 has a concave surface having a central stem 7 as a part thereof or firmly affixed therein.
- the central stem 7 has a central axis A-A (also referred to herein as a first central axis) and the central axis of the stem 7 is the same as the central axis of the cup 9.
- the cup 9 has at least one internally threaded screw hole having a central axis (also referred to herein as a second central axis) and a circumferential edge.
- the threaded screw hole is drilled at an angle such that lines extending from the circumferential edge and in parallel with the central axis of the screw hole do not intersect with the central stem.
- the screw holes 1 are threaded with threads 5 along the tapers thereof to mate with the tapered heads of the interlocking acetabular fixation screws.
- the tip of the interlocking acetabular fixation screw is self-tapping at 6 for ease of insertion into the bone of the patient.
- the acetabular cup 9 is impacted in position using an appropriate tool. Using drill guides for angular precision, holes are drilled to the appropriate depth.
- Interlocking acetabular fixation screws are then inserted until their fine threads 3 mate with the threads 5 of the tapered acetabular screw openings 1 and are tightly locked using a conventional hexagonal screwdriver. In doing so, the interlocking acetabular fixation screws become firmly and lockingly affixed with the acetabular cup 9, as if in one piece, subsequently eliminating any motion between the screw 10 and the cup 9. This is an extremely important factor in eliminating micromotion of the screw thereby reducing osteolysis.
- the interlocking acetabular fixation screws firmly secure the acetabular cup and prevent any retrograde migration of the screw head into the acetabular cup, which may cause impingement of the screw head with the moving femoral cup described in the PCT application incorporated by reference herein.
- interlocking acetabular fixation screws are sized for specific use with the reverse hip acetabular cup.
- the screws have an overall length a from 21 to 31 millimeters, a cancellous thread length b from 16 to 26 millimeters and a fine head thread length c from 4 to 5 millimeters.
- the cancellous thread diameter d is from 6 to 7 millimeters and the shank diameter e is from 4 to 5 millimeters.
Landscapes
- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161574984P | 2011-08-13 | 2011-08-13 | |
PCT/US2012/047518 WO2013025308A1 (fr) | 2011-08-13 | 2012-07-20 | Vis de fixation acétabulaire à verrouillage et leur combinaison avec une cupule acétabulaire pour hanche inversée |
Publications (3)
Publication Number | Publication Date |
---|---|
EP2741714A1 true EP2741714A1 (fr) | 2014-06-18 |
EP2741714A4 EP2741714A4 (fr) | 2014-08-13 |
EP2741714B1 EP2741714B1 (fr) | 2015-10-14 |
Family
ID=47715355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12824127.0A Active EP2741714B1 (fr) | 2011-08-13 | 2012-07-20 | Cupule acétabulaire pour hanche inversée et sa combinaison avec des vis de fixation acétabulaire à verrouillage |
Country Status (11)
Country | Link |
---|---|
US (1) | US9427321B2 (fr) |
EP (1) | EP2741714B1 (fr) |
JP (1) | JP6182139B2 (fr) |
KR (1) | KR101953291B1 (fr) |
CN (1) | CN103906482B (fr) |
AU (1) | AU2012295527B2 (fr) |
CA (1) | CA2842665C (fr) |
ES (1) | ES2558460T3 (fr) |
HK (1) | HK1194961A1 (fr) |
WO (1) | WO2013025308A1 (fr) |
ZA (1) | ZA201400534B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102006019620B4 (de) * | 2006-04-25 | 2015-10-01 | Merete Medical Gmbh | Künstliche Hüftpfanne und Hüftpfannensystem |
WO2016118196A1 (fr) | 2015-01-22 | 2016-07-28 | Crossroads Extremity Systems, Llc | Procédé de traitement d'au moins un premier kit |
ES2653538T3 (es) * | 2015-02-04 | 2018-02-07 | Alessandro Melozzi | Prótesis de cadera mejorada |
WO2017019325A1 (fr) | 2015-07-27 | 2017-02-02 | Hip Innovation Technology, LLC | Outil et procédé de séparation d'une cupule fémorale d'une bille acétabulaire dans une prothèse de hanche implantée |
US10245149B2 (en) * | 2015-08-03 | 2019-04-02 | Nicholas John Loffredo | Reverse total hip replacement |
AU2016311057B2 (en) * | 2015-08-21 | 2021-12-09 | Hip Innovation Technology, LLC | Surgical trays, instruments and methods for implanting a hip replacement prosthesis |
EP4268773A3 (fr) * | 2016-07-15 | 2024-01-24 | DJO Global, Inc. | Glénosphère à bride pour fixation augmentée et procédés associés |
CN106308979B (zh) * | 2016-08-31 | 2019-06-04 | 北京爱康宜诚医疗器材有限公司 | 髋臼假体 |
EP3565492B1 (fr) | 2017-01-09 | 2024-02-14 | Zimmer, Inc. | Montants de fixation poly-axiaux |
CN106983584A (zh) * | 2017-04-24 | 2017-07-28 | 北京爱康宜诚医疗器材有限公司 | 髋臼杯组件 |
EP3549552B1 (fr) * | 2018-04-06 | 2020-09-23 | Jossi Holding AG | Cupule d'articulation de la hanche |
KR102084625B1 (ko) * | 2020-02-05 | 2020-03-04 | 이동오 | 인대 고정용 골접합 나사 |
US11090163B1 (en) * | 2021-01-09 | 2021-08-17 | Zafer Termanini | Interlocking reverse hip prosthesis with removable tapered central post |
CN118121371B (zh) * | 2024-05-08 | 2024-07-12 | 吉林大学 | 一种自适配群桩承台髋臼假体 |
Citations (5)
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FR2545352A1 (fr) * | 1983-05-02 | 1984-11-09 | Gabard Jean Jacques | Prothese d'epaule |
WO2011005191A1 (fr) * | 2009-07-10 | 2011-01-13 | Milux Holding S.A. | Prothèse de hanche et méthode associée |
US20110054628A1 (en) * | 2009-08-26 | 2011-03-03 | Banks Stephen A | Reflex fixation geometry revision and reconstruction system reverse articulation |
WO2011112353A1 (fr) * | 2010-03-08 | 2011-09-15 | Hip Innovation Technology Llc | Blocage de hanche inversée et prothèse de remplacement |
US20120271425A1 (en) * | 2011-04-21 | 2012-10-25 | Brian Ted Maurer | Reverse joint replacement device and methods thereof |
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CH674927A5 (fr) * | 1988-04-25 | 1990-08-15 | Sulzer Ag | |
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CN102458311A (zh) * | 2009-05-07 | 2012-05-16 | 史密夫和内修有限公司 | 用于假体的模块化试验头 |
US8246687B2 (en) | 2009-11-18 | 2012-08-21 | Biomet Manufacturing Corp. | Shoulder prosthetic |
BR112012029287A2 (pt) * | 2010-05-18 | 2016-07-26 | Smith & Nephew Inc | sistemas de revisão de implantes e prótese de quadril |
CN201899585U (zh) * | 2010-12-21 | 2011-07-20 | 徐南伟 | 组配式髋表面置换假体 |
US9155632B2 (en) * | 2011-08-08 | 2015-10-13 | Hip Innovation Technology, LLC | Orthopedic instrument, system and method for implanting an acetabular cup |
-
2012
- 2012-07-20 WO PCT/US2012/047518 patent/WO2013025308A1/fr active Application Filing
- 2012-07-20 JP JP2014526032A patent/JP6182139B2/ja active Active
- 2012-07-20 CA CA2842665A patent/CA2842665C/fr active Active
- 2012-07-20 EP EP12824127.0A patent/EP2741714B1/fr active Active
- 2012-07-20 KR KR1020147004727A patent/KR101953291B1/ko active IP Right Grant
- 2012-07-20 US US14/237,599 patent/US9427321B2/en active Active
- 2012-07-20 CN CN201280039481.6A patent/CN103906482B/zh active Active
- 2012-07-20 ES ES12824127.0T patent/ES2558460T3/es active Active
- 2012-07-20 AU AU2012295527A patent/AU2012295527B2/en active Active
-
2014
- 2014-01-22 ZA ZA2014/00534A patent/ZA201400534B/en unknown
- 2014-08-21 HK HK14108533.1A patent/HK1194961A1/zh unknown
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FR2545352A1 (fr) * | 1983-05-02 | 1984-11-09 | Gabard Jean Jacques | Prothese d'epaule |
WO2011005191A1 (fr) * | 2009-07-10 | 2011-01-13 | Milux Holding S.A. | Prothèse de hanche et méthode associée |
US20110054628A1 (en) * | 2009-08-26 | 2011-03-03 | Banks Stephen A | Reflex fixation geometry revision and reconstruction system reverse articulation |
WO2011112353A1 (fr) * | 2010-03-08 | 2011-09-15 | Hip Innovation Technology Llc | Blocage de hanche inversée et prothèse de remplacement |
US20120271425A1 (en) * | 2011-04-21 | 2012-10-25 | Brian Ted Maurer | Reverse joint replacement device and methods thereof |
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Also Published As
Publication number | Publication date |
---|---|
US20140336778A1 (en) | 2014-11-13 |
CN103906482B (zh) | 2015-12-09 |
KR101953291B1 (ko) | 2019-02-28 |
AU2012295527A1 (en) | 2014-01-23 |
JP2014531919A (ja) | 2014-12-04 |
US9427321B2 (en) | 2016-08-30 |
CN103906482A (zh) | 2014-07-02 |
HK1194961A1 (zh) | 2014-10-31 |
EP2741714B1 (fr) | 2015-10-14 |
AU2012295527B2 (en) | 2016-08-25 |
JP6182139B2 (ja) | 2017-08-16 |
KR20140047142A (ko) | 2014-04-21 |
CA2842665A1 (fr) | 2013-02-21 |
ZA201400534B (en) | 2020-05-27 |
WO2013025308A1 (fr) | 2013-02-21 |
ES2558460T3 (es) | 2016-02-04 |
CA2842665C (fr) | 2016-04-12 |
EP2741714A4 (fr) | 2014-08-13 |
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