EP2723354A4 - Compositions, utilisations et préparation de lysats de plaquettes - Google Patents

Compositions, utilisations et préparation de lysats de plaquettes

Info

Publication number
EP2723354A4
EP2723354A4 EP12804449.2A EP12804449A EP2723354A4 EP 2723354 A4 EP2723354 A4 EP 2723354A4 EP 12804449 A EP12804449 A EP 12804449A EP 2723354 A4 EP2723354 A4 EP 2723354A4
Authority
EP
European Patent Office
Prior art keywords
compositions
preparation
platelet lysates
lysates
platelet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP12804449.2A
Other languages
German (de)
English (en)
Other versions
EP2723354A1 (fr
EP2723354B3 (fr
EP2723354B1 (fr
Inventor
Ian B Copland
Jacques Galipeau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emory University
Childrens Healthcare of Atlanta Inc
Original Assignee
Emory University
Childrens Healthcare of Atlanta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47424507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP2723354(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Emory University, Childrens Healthcare of Atlanta Inc filed Critical Emory University
Publication of EP2723354A1 publication Critical patent/EP2723354A1/fr
Publication of EP2723354A4 publication Critical patent/EP2723354A4/fr
Application granted granted Critical
Publication of EP2723354B1 publication Critical patent/EP2723354B1/fr
Publication of EP2723354B3 publication Critical patent/EP2723354B3/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0664—Dental pulp stem cells, Dental follicle stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0666—Mesenchymal stem cells from hair follicles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/42—Anti-thrombotic agents, anticoagulants, anti-platelet agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/115—Platelets, megakaryocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP12804449.2A 2011-06-27 2012-06-26 Compositions, utilisations et préparation de lysats de plaquettes Active EP2723354B3 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161501411P 2011-06-27 2011-06-27
US201161547897P 2011-10-17 2011-10-17
PCT/US2012/044211 WO2013003356A1 (fr) 2011-06-27 2012-06-26 Compositions, utilisations et préparation de lysats de plaquettes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP20176185.5 Division-Into 2020-05-22

Publications (4)

Publication Number Publication Date
EP2723354A1 EP2723354A1 (fr) 2014-04-30
EP2723354A4 true EP2723354A4 (fr) 2015-03-11
EP2723354B1 EP2723354B1 (fr) 2020-05-27
EP2723354B3 EP2723354B3 (fr) 2021-03-24

Family

ID=47424507

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12804449.2A Active EP2723354B3 (fr) 2011-06-27 2012-06-26 Compositions, utilisations et préparation de lysats de plaquettes

Country Status (8)

Country Link
US (2) US9688959B2 (fr)
EP (1) EP2723354B3 (fr)
JP (1) JP6179955B2 (fr)
CN (2) CN103702674B (fr)
AU (1) AU2012275562B2 (fr)
CA (1) CA2840568C (fr)
ES (1) ES2811085T7 (fr)
WO (1) WO2013003356A1 (fr)

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US20160002598A1 (en) * 2013-01-28 2016-01-07 Regenerative Science, LLC Device and methods for platelet lysis or activation
US10905721B2 (en) 2013-01-28 2021-02-02 Regenexx, Llc. Device and methods for platelet lysis or activation
CA2922205C (fr) 2013-08-27 2021-08-17 Cook General Biotechnology Llc Compositions bioactives pouvant etre derivees de concentres de plaquettes, et procedes de preparation et d'utilisation de celles-ci
HK1194912A2 (en) * 2013-09-17 2014-10-24 Bestop Group Holdings Ltd Growth factor concentrate and the use thereof
AU2015236088A1 (en) * 2014-03-25 2016-11-10 Cook Biotech Incorporated Extracellular matrix grafts loaded with exogenous factors
WO2016116560A1 (fr) * 2015-01-21 2016-07-28 Turkof Edvin Concentré de plaquettes pour l'augmentation de la régénération de cellules et la croissance de cellules
WO2016132357A1 (fr) * 2015-02-16 2016-08-25 Nayacure Therapeutics Ltd. Caillots modifiés
CA2987872A1 (fr) * 2015-05-29 2016-12-08 Amit Patel Compositions de lysat de plaquettes lyophilisees particulaires
CN107304412A (zh) * 2016-04-22 2017-10-31 南京医科大学第附属医院 视网膜色素上皮细胞的培养基及其应用
EP3254684B1 (fr) 2016-06-08 2019-10-23 Lysatpharma GmbH Lysat de plaquettes humaines ou fraction enrichie de vésicules extracellulaires dérivées de lysat de plaquettes humaines pour utilisation medicale
WO2018005751A1 (fr) * 2016-06-29 2018-01-04 Arteriocyte, Inc. Pansements composés d'un lysat de plaquettes.
EP3558411B1 (fr) * 2016-12-22 2024-04-17 Regenexx, LLC Dispositif et procédés de lyse ou d'activation plaquettaire
IT201700026465A1 (it) * 2017-03-09 2018-09-09 Biorigen S R L Supplementi per colture cellulari
EP3638263B1 (fr) 2017-06-16 2023-08-23 Centre Hospitalier Régional et Universitaire de Lille (CHRU) Procédé de préparation d'un lysat de plaquettes humaines regroupées en pool et leur utilisation pour le traitement de troubles neurologiques
KR20200104300A (ko) * 2017-12-22 2020-09-03 키에시 파르마슈티시 엣스. 피. 에이. 중간엽 기질세포 및 탯줄로부터 중간엽 기질세포를 얻기 위한 방법
FR3077824B1 (fr) 2018-02-15 2022-01-14 Maco Pharma Sa Procede de preparation d'un lysat plaquettaire irradie
FR3077823B1 (fr) 2018-02-15 2022-01-14 Maco Pharma Sa Procede de preparation d'un lysat plaquettaire irradie
CN108823156A (zh) * 2018-07-04 2018-11-16 陕西神州生物技术有限公司 用于修复的临床级人脐带间充质干细胞复合因子及冻干粉的制备方法
CN112912101A (zh) * 2018-08-07 2021-06-04 爱菲斯医疗有限公司 血小板裂解物组合物及其用途
JP7416786B2 (ja) * 2018-11-14 2024-01-17 オンデルゾークス・エン オントビッケリングスフォンズ オーデ クラウス・フランデレン 血小板放出物を調製するための方法
EP3886879A4 (fr) 2018-11-30 2022-12-07 Cellphire Inc. Plaquettes en tant qu'agents de livraison
EP3887404A4 (fr) 2018-11-30 2022-11-02 Cellphire, Inc. Plaquettes chargées d'agents anticancéreux
EP3920944A4 (fr) * 2019-02-07 2023-03-29 Biobridge Global Méthodes et compositions associées à un produit de libération de plaquettes et à la fibrine riche en plaquettes
SG11202112054WA (en) 2019-05-03 2021-11-29 Cellphire Inc Materials and methods for producing blood products
AU2020277774A1 (en) * 2019-05-22 2021-12-09 Thankstem S.R.L. Method for expanding adult stem cells from whole blood
BR112022002892A2 (pt) 2019-08-16 2022-05-24 Cellphire Inc Trombossomos como um agente de reversão de agente antiplaqueta
CA3152224A1 (fr) * 2019-08-22 2021-02-25 Abdalla S. AWIDI Procede de preparation d'un lysat de plaquettes sans fibrine et utilisations dudit procede
WO2021158622A1 (fr) 2020-02-04 2021-08-12 Cellphire, Inc. Plaquettes chargées antifibrinolytiques
CN111303270B (zh) * 2020-02-18 2022-04-01 浙江中医药大学 一种利用套装制备血小板生长因子浓集物的方法
EP3881858A1 (fr) 2020-03-20 2021-09-22 Rok Pangersic Extrait de facteur de croissance dérivé de plaquettes traité à la chaleur destiné à être utilisé dans un procédé de prévention ou de traitement de défaut d'un tissu
CN111569139A (zh) * 2020-05-26 2020-08-25 上海市第六人民医院 一种负载血小板裂解液的自支撑自组装多层膜及其应用
EP4190892A1 (fr) * 2020-07-31 2023-06-07 Rainbow Inc. Lysat de plaquettes dérivé de plaquettes autologues
CN113667636A (zh) * 2021-07-13 2021-11-19 安徽农业大学 猪血小板裂解液及其制备方法
CN114058576A (zh) * 2021-11-22 2022-02-18 新乡医学院 一种血小板裂解液及其制备方法和应用
CN114317430A (zh) * 2021-12-28 2022-04-12 河北银丰鼎诚生物技术有限公司 一种适用于脐血来源免疫细胞扩增的培养液
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AU2012275562B2 (en) 2016-10-20
EP2723354A1 (fr) 2014-04-30
EP2723354B3 (fr) 2021-03-24
ES2811085T3 (es) 2021-03-10
CA2840568A1 (fr) 2013-01-03
CA2840568C (fr) 2021-05-04
US20170304365A1 (en) 2017-10-26
AU2012275562A1 (en) 2014-01-23
US9688959B2 (en) 2017-06-27
CN103702674A (zh) 2014-04-02
US20140127314A1 (en) 2014-05-08
CN108671224B (zh) 2022-12-13
EP2723354B1 (fr) 2020-05-27
CN108671224A (zh) 2018-10-19
CN103702674B (zh) 2018-05-29
JP2014522833A (ja) 2014-09-08
JP6179955B2 (ja) 2017-08-16
WO2013003356A1 (fr) 2013-01-03
ES2811085T7 (es) 2021-11-29

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