EP2717762A1 - Canule de prélèvement de sang d'une pompe remplaçant ou assistant la fonction cardiaque - Google Patents

Canule de prélèvement de sang d'une pompe remplaçant ou assistant la fonction cardiaque

Info

Publication number
EP2717762A1
EP2717762A1 EP12724909.2A EP12724909A EP2717762A1 EP 2717762 A1 EP2717762 A1 EP 2717762A1 EP 12724909 A EP12724909 A EP 12724909A EP 2717762 A1 EP2717762 A1 EP 2717762A1
Authority
EP
European Patent Office
Prior art keywords
ventricle
volume
heart
pressure
cannula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12724909.2A
Other languages
German (de)
English (en)
Inventor
Marc Hein
Greatex NICHOLAS
Roland GRAEFE
Ulrich Steinseifer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
REINHEART GmbH
Original Assignee
Rheinisch Westlische Technische Hochschuke RWTH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rheinisch Westlische Technische Hochschuke RWTH filed Critical Rheinisch Westlische Technische Hochschuke RWTH
Publication of EP2717762A1 publication Critical patent/EP2717762A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/0265—Measuring blood flow using electromagnetic means, e.g. electromagnetic flowmeter
    • A61B5/027—Measuring blood flow using electromagnetic means, e.g. electromagnetic flowmeter using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02028—Determining haemodynamic parameters not otherwise provided for, e.g. cardiac contractility or left ventricular ejection fraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/026—Measuring blood flow
    • A61B5/029—Measuring or recording blood output from the heart, e.g. minute volume
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0538—Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6869—Heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/165—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart
    • A61M60/178—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/205—Non-positive displacement blood pumps
    • A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/508—Electronic control means, e.g. for feedback regulation
    • A61M60/515—Regulation using real-time patient data
    • A61M60/531—Regulation using real-time patient data using blood pressure data, e.g. from blood pressure sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/508—Electronic control means, e.g. for feedback regulation
    • A61M60/538—Regulation using real-time blood pump operational parameter data, e.g. motor current
    • A61M60/554—Regulation using real-time blood pump operational parameter data, e.g. motor current of blood pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/857—Implantable blood tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3344—Measuring or controlling pressure at the body treatment site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates

Definitions

  • Blood collection cannula of a heart function replacing or
  • the invention relates to a blood collection cannula for connecting a
  • the invention further relates to a measuring device for monitoring the
  • Ventricular contractions and / or the function of a cardiac function replacing or supporting pump as well as a method for adjusting the flow rate and / or the delivery pressure of the cardiac function replacing or supporting pump, which conveys blood by means of a blood collection cannula from a ventricle of the heart and into the aorta of the Heart into it.
  • a pump to support the heart function, such as continuously operating centrifugal pumps or any other type of pump.
  • a pump delivers blood from a ventricle of the heart, e.g. from the left ventricle, for which purpose a blood collection cannula is inserted into the ventricle, in particular in the apex region of the heart, through which the blood is conveyed from the ventricle into the pump.
  • the pump When connected to the left ventricle, the pump then delivers the blood to the aorta.
  • the blood collection cannula of the aforementioned publication in this case has a pressure sensor at the end of the blood collection cannula, which lies in the ventricle. It has been found here that ventricular contractions can be evaluated based on the pressure and motor lead of the pump.
  • volume flow / delivery pressure is substantially constant and is initially adjusted by experienced clinical staff.
  • the volume flow / delivery pressure should be large enough to ensure sufficient cardiac support, but not too high to avoid collapse of the ventricle.
  • This setting may e.g. be detected with additional sensors that are introduced for this purpose briefly in the heart, but can not remain there for a long time.
  • sensors have drift problems over time, and an optimum volumetric flow rate of the pump can also vary depending on other variables, e.g. in dependency of
  • a blood sampling cannula of the type mentioned at the same end of the cannula lying in the ventricle also has a volume sensor for measuring in addition to the pressure sensor the volume and / or volume changes of the ventricle in at least a portion of the ventricle.
  • the ventricular contraction can be monitored and evaluated, in particular the work done by the heart in the left ventricle.
  • Volume sensor is detected an absolute reading, but it is
  • the work done by the heart and left ventricle is the area of a closed line in the P-V diagram of the ventricular contraction at each heartbeat. This area is independent of the absolute pressure or volume size, so that the detection of changes in these quantities is sufficient to determine a measure of the work.
  • volume change in the ventricular part and the total volume a relationship, in particular a linear relationship exists. This relationship can be taken into account in the evaluation of the volumetric measured values.
  • the invention thus offers the possibility of the sensors on the
  • Blood collection cannula to monitor the ventricular contraction at any time
  • the measured values of volume and pressure in the ventricle can be tapped at any time on the blood sampling cannula, e.g. for the purpose of external evaluation or by evaluation with a to the
  • Blood collection cannula or measuring device provided on the pump. It can be such a doctor at any time a change in the pumping speed or the volume flow / delivery pressure to be made, which s.den
  • Measured values or the calculated ventricular work or heart work or their temporal change can be monitored.
  • the heart work initially increases, namely on such an area in which the heart works work to open the aortic valve against the pressure of the pumping into the aorta until the heart work significantly decreases, from one
  • the volume flow / delivery pressure of the pump so that an operating point of the pump is reached, in which the heart valve during the heartbeats remains closed.
  • this operating point may be e.g. can be found by falling below a maximum measured heart work by a certain amount, percentage or absolute, or even by
  • Increase in cardiac work e.g., difference quotient of cardiac work and
  • Volume sensor is designed as a pin which is pointing away from the cannula end, in particular into the interior of the ventricle and on his
  • Surface has two electrodes spaced apart in the direction of stretching of the pen, by means of which a potential difference is applied to the electrodes by applying a potential difference
  • the pressure sensor may, for example, also be arranged on the pin or at the end of the cannula.
  • the length of Stiftes and the arrangement of the electrodes to be chosen so that the
  • Electrodes that define the measurement area are located centrally in the ventricle,
  • hearts can vary in size from person to person, it can be provided here to provide different designs of blood collection cannulae, from which a suitable one can be selected depending on the size of the heart.
  • the cannula itself has at its end located in the ventricle on the outer surface two spaced apart in Kangenerumblete electrodes, by means of which by applying a potential difference, a current flow through the blood of the ventricle can be generated and between which at least two measuring electrodes are arranged, with which one between the measuring electrodes at a current flow
  • Pressure sensor also located at the end of the cannula.
  • Messelelektroden the volume of the ventricle in a range around each considered measuring electrodes around are determined. This results from the fact that more blood (larger volume) has a lower resistance and thereby the voltage drop is smaller than with a smaller blood volume, which surrounds the measuring electrodes.
  • the distance between the electrodes to which the potential difference is applied to produce a current flow need not be as large as the entire ventricular length, so a volume sensor need not extend through the entire ventricular volume, so as to have a plurality of Measuring electrodes (pairs) to calculate the entire volume of the ventricle.
  • a monitored ventricular component length in particular less than or equal to 50% of the total ventricular length between cardiac apex and aortic valve may be sufficient.
  • at least two measuring electrodes are provided to determine the part blood volume arranged around it, from which, for example extrapolation allows the actual volume to be calculated on the basis of the linear relationship mentioned above.
  • a measuring device which can be connected to the pressure sensor and the volume sensor of a blood collection cannula of the described type according to the invention and which is adapted to detect pressure changes and volume changes of a ventricle, ie the measured values of the aforementioned sensors, thus in particular to measure and save.
  • the measuring device generates a voltage difference between the two outermost of the electrodes, in order to generate a current flow and during the heartbeats measures the at least one voltage drop across the at least two measuring electrodes arranged therebetween, as well as simultaneously the pressure by means of the pressure sensor.
  • the measuring device can be set up in a development, from measured volume changes and pressure changes a measure of the
  • Such a measure may e.g. be provided to a treating physician, e.g. by a readout of the data from the measuring device or a display or it is used directly to control the pump.
  • a measuring device can be set up to output a control signal from measured volume changes and pressure changes for a volumetric flow / delivery pressure to be set for a pump replacing or supporting the cardiac function, e.g. a signal for speed control.
  • volume changes in the ventricular contractions are detected and from these changes a measure of the current heart work is determined and adjusted in dependence of this measure, the flow / delivery pressure of the pump and / or adjusted.
  • the detected measured values can be supplied, for example, to a filtering and / or evaluation logic in the measuring apparatus or an algorithm in order to obtain the
  • Volume flow or delivery pressure can in particular be such that the aortic heart valve of the left ventricle in the ventricular contractions
  • this can be done by observing the amount of cardiac work above the volume flow / delivery pressure or the rotational speed of the pump to determine the point at which the heart work increases with increasing
  • Volume sensor are each arranged on one element, namely the blood collection cannula of the heart pump and this element during the duration of
  • the sensors will not cause additional stress, as would be the case if sensors were placed through the aorta into the heart.
  • the invention is very well suited for long-term monitoring of the heart function supporting or replacing pump as well as the supported ventricle.
  • a change in cardiac work can also be determined, e.g. by calculating the derivative of the volume sensor signal (or the volume calculated therefrom) over time. Minimum values of this change are highly sensitive to systole or contraction of the ventricle.
  • the measuring device is set up to carry out all the steps described for the method, in particular for which e.g. in the measuring device
  • Microprocessor can be provided and software for performing the respective steps.
  • FIG. 1 shows symbolizes the lower apex area of a heart with a blood withdrawal cannula 4 inserted in the left ventricle 1
  • Blood collection cannula 4 is connected to a pump 2, e.g.
  • a continuously running centrifugal pump takes blood from the left ventricle 1 of the heart and delivers it into the aorta, increasing the pressure in the aorta.
  • the pressure side of the pump 2 and the connection to the aorta are not shown here.
  • the heart Due to the inherent ventricular contraction, the heart promotes the blood against this pressure through the aortic valve, until a pressure is generated in the aorta by the pump against which the heart no longer pumps. From this pressure, the heart is relieved and the pumping function is taken over by the pump.
  • At the blood collection cannula 4 is both a pressure sensor 7b and a
  • volume sensor 3b arranged.
  • the volume sensor 3b is formed by a pin 3b, which at least partially projects from the cannula into the ventricle 1 and has a plurality of electrodes 5, 6 on its outer side, which are axially spaced apart.
  • the pressure sensor 7b is arranged here at the outer end of the pin 3b.
  • a potential difference or voltage may be applied to create a current flow through the surrounding blood.
  • a linear relationship can be calculated back to the entire volume in a development.
  • This relationship can e.g. in an upstream step, with a sensor that measures the entire heart volume. Such a step can also be omitted.
  • Figure 2 shows an alternative in which the aforementioned electrodes 5 and 6 are not disposed on a pin which is fixed to the cannula end, but here the same electrodes 5, 6 are arranged directly on the outside of the cannula 4, which is correspondingly far inserted into the ventricle 2.
  • the measurement of the (partial) volume of the ventricle takes place in the same way.
  • the pressure sensor 7a is arranged inside the outer end of the cannula 4 in this embodiment.
  • FIG. 3 shows a P-V diagram in the case of a heartbeat of the heart
  • the work WL that applies the heart results from the area of the closed polyline and may be e.g. be calculated by integration. Obviously, this area is independent of the absolute values of pressure and volume, so that in the invention no absolutely calibrated sensors for
  • volume determination is possible, the determined measure of heart work is not an absolute size. However, FIG. 4 shows here that the measured
  • Figure 5 shows the relationship between the heart work on the Y-axis and the speed of the pump, which has an influence on the flow rate and delivery pressure of the pump.
  • the curve A shows the relationship based on the cardiac work, which was determined in determining the total ventricular volume and curve B, taking into account only a partial volume, which can be done with the above volume sensor.
  • this point P can e.g. can be determined by comparing the slope of the heart work with a stored comparison value. If the negative slope is smaller or the slope amount greater than the comparison value, then this operating point of the pump is reached or exceeded. Also can be rehearsed on a change of sign in the slope. In the plateau region, the slope is slightly positive, whereas in the vicinity of the point P the slope becomes strongly negative.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Mechanical Engineering (AREA)
  • Anesthesiology (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Electromagnetism (AREA)
  • External Artificial Organs (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

L'invention concerne une canule de prélèvement de sang (4) destinée à relier une pompe (2) assistant ou remplaçant la fonction cardiaque au volume intérieur d'un ventricule cardiaque (1), en particulier du ventricule gauche. Ladite canule comporte à son extrémité située dans le ventricule un capteur de pression (7a, 7b) destiné à mesurer la pression ventriculaire et/ou les différences de pression ventriculaire et comporte sur cette même extrémité un capteur de volume (3a, 3b, 5, 6) destiné à mesurer le volume et/ou les variations du volume du ventricule (1) dans au moins une zone partielle du ventricule. L'invention concerne en outre un dispositif de mesure destiné à surveiller les contractions ventriculaires et/ou la fonction d'une pompe remplaçant ou assistant la fonction cardiaque. Ladite pompe peut être raccordée/est raccordée au capteur de pression (7a, 7b) et au capteur de volume d'une canule de prélèvement de sang et est configurée pour détecter des variations de pression et des variations de volume d'un ventricule (1) pendant le rythme cardiaque.
EP12724909.2A 2011-06-10 2012-05-25 Canule de prélèvement de sang d'une pompe remplaçant ou assistant la fonction cardiaque Withdrawn EP2717762A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011106142A DE102011106142A1 (de) 2011-06-10 2011-06-10 Blutentnahmekanüle einer die Herzfunktion ersetzenden oder unterstützenden Pumpe
PCT/EP2012/002245 WO2012167876A1 (fr) 2011-06-10 2012-05-25 Canule de prélèvement de sang d'une pompe remplaçant ou assistant la fonction cardiaque

Publications (1)

Publication Number Publication Date
EP2717762A1 true EP2717762A1 (fr) 2014-04-16

Family

ID=46201561

Family Applications (1)

Application Number Title Priority Date Filing Date
EP12724909.2A Withdrawn EP2717762A1 (fr) 2011-06-10 2012-05-25 Canule de prélèvement de sang d'une pompe remplaçant ou assistant la fonction cardiaque

Country Status (7)

Country Link
US (1) US20140114202A1 (fr)
EP (1) EP2717762A1 (fr)
CN (1) CN103857326B (fr)
AU (1) AU2012266809B2 (fr)
CA (1) CA2842522A1 (fr)
DE (1) DE102011106142A1 (fr)
WO (1) WO2012167876A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2796156A1 (fr) * 2013-04-24 2014-10-29 ETH Zurich Appareil biomédical destiné à pomper le sang d'un patient humain ou animal par un circuit sanguin intra ou extracorporel secondaire
JP6616405B2 (ja) 2014-05-29 2019-12-04 セントビンセンツ ホスピタル シドニー リミテッド 心室補助人工心臓の方法及び装置
EP2962710A1 (fr) 2014-07-03 2016-01-06 Berlin Heart GmbH Procédé et système d'assistance ventriculaire destinés à déterminer une pression d'évacuation
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CA2842522A1 (fr) 2012-12-13
DE102011106142A1 (de) 2012-12-27
AU2012266809A1 (en) 2014-01-09
CN103857326A (zh) 2014-06-11
CN103857326B (zh) 2015-12-02
WO2012167876A1 (fr) 2012-12-13
AU2012266809B2 (en) 2016-07-14
US20140114202A1 (en) 2014-04-24

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