EP2688675A1 - Dispositif et procédé de séparation d'un résidu surnageant dans un échantillon liquide et utilisation d'un dispositif soupape comportant une membrane soluble - Google Patents

Dispositif et procédé de séparation d'un résidu surnageant dans un échantillon liquide et utilisation d'un dispositif soupape comportant une membrane soluble

Info

Publication number
EP2688675A1
EP2688675A1 EP12710096.4A EP12710096A EP2688675A1 EP 2688675 A1 EP2688675 A1 EP 2688675A1 EP 12710096 A EP12710096 A EP 12710096A EP 2688675 A1 EP2688675 A1 EP 2688675A1
Authority
EP
European Patent Office
Prior art keywords
receiving space
supernatant
sample
opens
valve device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP12710096.4A
Other languages
German (de)
English (en)
Inventor
Christian Schoen
Tanja Thiele
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Microparts GmbH
Original Assignee
Boehringer Ingelheim Microparts GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Microparts GmbH filed Critical Boehringer Ingelheim Microparts GmbH
Priority to EP12710096.4A priority Critical patent/EP2688675A1/fr
Priority to EP20154836.9A priority patent/EP3682970A1/fr
Publication of EP2688675A1 publication Critical patent/EP2688675A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021—Test tubes specially adapted for centrifugation purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2676—Centrifugal separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/08—Polysaccharides
    • B01D71/10—Cellulose; Modified cellulose
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/22—Testing for sterility conditions
    • E—FIXED CONSTRUCTIONS
    • E21—EARTH OR ROCK DRILLING; MINING
    • E21B—EARTH OR ROCK DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
    • E21B25/00—Apparatus for obtaining or removing undisturbed cores, e.g. core barrels or core extractors
    • E—FIXED CONSTRUCTIONS
    • E21—EARTH OR ROCK DRILLING; MINING
    • E21B—EARTH OR ROCK DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
    • E21B25/00—Apparatus for obtaining or removing undisturbed cores, e.g. core barrels or core extractors
    • E21B25/08—Coating, freezing, consolidating cores; Recovering uncontaminated cores or cores at formation pressure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells

Definitions

  • the present invention relates to a device for separating a supernatant of a liquid sample according to the preamble of claim 1, a method for separating a supernatant of a liquid sample according to the preamble of claim 9 and a use of a valve device with a soluble membrane.
  • the present invention is concerned with the manipulation or concentration of a liquid sample, in particular a suspension.
  • a liquid sample in particular a suspension.
  • This is in particular a biological sample or sample liquid, in particular blood, urine or any other human or animal body fluid.
  • centrifugation can take place. So far, however, it is disadvantageous that the supernatant of the centrifuged sample manually, for example, with a pipette, separated or removed.
  • the present invention has for its object to provide an apparatus and a method for separating a supernatant of a liquid sample and a use of a valve device with a soluble membrane, wherein a simplified, in particular automated or automatic manipulation of the liquid sample is possible or easier.
  • One aspect of the present invention is that for the separation of a supernatant of a liquid sample, a receiving space is provided with a drain, wherein the flow is assigned a Ventili direction. So the expiration or deflation of the supernatant of the liquid sample can be carried out in a targeted or controlled manner. In particular, centrifugation of the sample can first be carried out and then the supernatant can be removed from the receiving space by opening the valve device and thus separated. This allows a very simple manipulation of the liquid sample. In particular, the use of a pipette or the like. To separate the supernatant is not required.
  • the valve device preferably opens automatically and / or by dissolving a membrane and / or by bursting when reaching or exceeding a certain pressure. This simplifies handling substantially.
  • the sample is centrifuged in the receiving space and then - in particular by centrifugal and / or gravitational force - derived from the receiving space via a drain that is temporarily closed and / or opens automatically.
  • a drain that is temporarily closed and / or opens automatically.
  • Another aspect of the present invention is to provide a valve device having a soluble membrane for temporarily retaining a liquid in a receiving space or for a normally closed valve device.
  • the valve device opens by dissolving or dissolving the membrane by the liquid automatically. This allows a very simple structure and allows a very simple manipulation or handling.
  • the present invention is concerned in particular with the concentration of f ure components of the liquid sample.
  • the concentrated constituents can then be passed on to a further examination while the supernatant is separated or diverted and in particular can be discarded.
  • the proposed valve device can in principle also be used for other purposes.
  • FIGURE shows: a schematic section of a device according to the proposal.
  • the figure shows in a schematic section a proposed device 1 for manipulating a liquid sample 2.
  • the sample 2 is a particle-containing solution or suspension with in particular solid constituents 3.
  • the sample 2 is a biological sample or liquid
  • blood, urine or any other human or natural body fluid for example, blood, urine or any other human or natural body fluid.
  • other liquids or suspensions or the like can be manipulated as sample 2.
  • the device 1 is particularly preferably the concentration of solid or non-soluble components 3 of the sample 2 and / or the separation of a supernatant of the sample 2, in particular so the supernatant liquid after concentration of the components.
  • the device 1 is used in particular for centrifugation. Particularly preferably, the device 1 can be used or centrifuged in a centrifuge, not shown.
  • a concentration of the components 3 has already taken place in a lower region.
  • the figure therefore shows in particular a stood after a centrifugation. However, the supernatant of liquid or the sample 2 has not been separated or derived.
  • the device 1 preferably has a receiving space 4 for receiving the sample 2 and an associated outlet 5 for discharging, in particular a supernatant of the liquid or sample 2.
  • the device 1 can also have or form a collecting space 6 in order to pass through the drain 5 derived supernatant or through the drain 5 derived liquid or the like. Capture.
  • the receiving space 4 is preferably formed in an upper part 7 of the device 1 and the collecting space 6 is preferably formed in a lower part 8 of the device 1.
  • the upper part 7 and the lower part 8 are preferably formed as separate components.
  • the lower part 7 and the upper part 8 are preferably releasably connectable to each other.
  • the upper part 7 and the lower part 8 are preferably non-positively or positively connected to each other, in particular by plugging, by screwing, by a bayonet lock, by a snap connection or the like.
  • the lower part 8 on the upper part 7 can be plugged or vice versa.
  • the upper part 7 is connected to the lower part 8.
  • the upper part 7 and the lower part 8 can also be formed by a common component.
  • the lower part 8 may be in this case, for example, via a predetermined breaking point optionally from the upper part 7 (completely) separable or detachable. However, it is also possible that the upper part 7 and the lower part 8 are not separable from each other (completely).
  • the lower part 8 is held or secured on the upper part 7 such that the lower part 8 does not detach from the upper part 7 during the centrifugation of the sample 2 or device 1.
  • the device 1 is preferably formed at least substantially elongated or tube-like and / or hollow cylindrical. However, other embodiments are possible.
  • the drain 5 is preferably arranged in an opposite end region or in a bottom region and / or in an area adjacent to the lower part 8.
  • the device 1 preferably has a retaining region 9, which is formed in the receiving space 4 or upper part 7 and in particular serves to receive a residue of the sample 2, in particular the concentrated sample 2 or components 3, as indicated schematically in the figure.
  • the retaining region 9 is preferably formed by an end wall-side section or bottom 10 of the receiving space 4 or upper part 7.
  • the bottom 10 is preferably substantially funnel-like or conical in the illustrated embodiment.
  • the bottom 10 is preferably formed integrally with the upper part 7.
  • the drain 5 is formed integrally with the upper part 7 or bottom 10.
  • the drain 5 preferably extends in such a way into the receiving space 4, in particular beyond the bottom 10 or retaining area 9, into the receiving space 4, so that only liquid or supernatant above the retaining area 9 is discharged from the receiving space 4 through the drain 5 when the drain 5 is open becomes.
  • the process 5 therefore opens above the bottom 10 into the receiving space 4.
  • the drain 5 is preferably tubular or hollow cylindrical in the illustrated embodiment.
  • the drain 5 preferably extends in the main extension direction of the device 1 in the illustrated embodiment.
  • the receiving space 4 or the upper part 7 is preferably open at the top or at the end remote from the drain 5 or bottom 10 for receiving the sample 2.
  • the illustration shows a preferred orientation of the device 1, in which the upper part 7 or the receiving space 4 above is located, wherein the retaining portion 9 is located below and the drain 5 is also located below.
  • This alignment of the device 1 is particularly true when a derivative of the liquid or the supernatant through the drain 5 is carried out by gravitational force or should take place.
  • the device 1 can in principle also have any other suitable orientation, in particular depending on the direction of an acting centrifugal force, particularly preferred if the discharge of the supernatant or liquid from the receiving space 4 through the outlet 5 by centrifugal force or (also) under the Action takes place or should take place.
  • the upper part 7 or lower part 8 is preferably made of plastic and / or as an injection molded part.
  • the device 1 preferably has a valve device 11, which is assigned in particular to the outlet 5.
  • the valve device 11 preferably closes the drain 5 temporarily or normally.
  • the valve device 11 is preferably designed such that it opens automatically and / or after a predetermined time, in particular after filling or receiving the sample 2 in the receiving space 4.
  • the valve device 11 preferably has a membrane 12 or is formed therefrom.
  • the membrane 12 is preferably soluble, in particular water-soluble. Particularly preferably, the membrane 12 is dissolved, dissolved or attacked by the sample 2. It can thus be achieved that the valve device 11 or membrane 12 opens or opens or releases the drain 5.
  • the time to open or release is preferably a few minutes, in particular more than 10 minutes, more preferably more than 20 minutes. This leaves enough time, for example, first to centrifuge the device 1 or sample 2 after the sample 2 has been introduced into the receiving space 4. The opening of the valve device 1 1 or the membrane 12 is then carried out as needed during the centrifugation or thereafter, and then the supernatant of the sample 2, that is, the liquid above the opening of the Ab ⁇ run 5 to separate or divert from the receiving space 4, in particular in the collecting space. 6
  • the membrane 12 is preferably formed relatively thick-walled to withstand the stresses occurring during centrifugation.
  • valve device 11 or membrane 12 may also be designed such that it opens, breaks or bursts upon reaching or exceeding a certain pressure and / or a force acting thereon, in particular centrifugal force.
  • an opening of the valve device 11 or the membrane 12 and thus of the drain 5 can also be achieved by centrifugally increasing or increasing the centrifugal speed after a first centrifugation or centrifuging so that the valve device 11 resp the membrane 12 breaks or bursts or otherwise opens.
  • the Zentiifugation can thus be done for example in two stages or at two speeds.
  • the speed or rotational speed can also be increased continuously or in steps or in any other way.
  • the supernatant or the liquid located above the opening of the drain 5 in the receiving space 4 is, after opening the valve device 11 or membrane 12, preferably drained out of the receiving space 4 through the drain 5 by centrifugal force and / or gravitational force.
  • the derived supernatant or the discharged liquid is preferably collected or received in the receiving space 6 of the lower part 8.
  • the concentrated sample 2 which has remained in the retention area 9 can be widely used, for example for examinations or other manipulations.
  • the lower part 8 can, if necessary, be detached from the upper part 7.
  • the removal can also be removed via the preferably overhead filling opening of the receiving space 4 or upper part 7, wherein this may need to be reopened first if it is necessary for the centrifugation has been closed, for example, by a stopper, closure or the like, not shown.
  • the volume of the retention area 9 or the sample 2 retained or concentrated in the collecting space 4 can be set or determined by the length of the drainage tube or the height of the opening of the outlet 5 in the receiving space 4.
  • the valve device 11 or membrane 12 closes the drain 5 preferably in the manner of a plug and / or over its entire surface and / or at least in a liquid-tight manner.
  • valve device 11 or membrane 12 is preferably arranged on the receiving chamber-side or inlet-side end of the particular tube-shaped drain 5.
  • valve unit 11 or membrane 12 can alternatively or additionally also be arranged at the other end or outlet-side end of the outlet 5 and / or between the ends.
  • the drain 5 may be at least substantially completely filled by the valve device 11 or a water-soluble material in particular.
  • membranes 12 can also be used. Alternatively or additionally, a valve device 11 or membrane 12 may be arranged at each end of the drain 5.
  • the valve device 11 or membrane 12 opens preferably without manual external influence or without external influences, in particular after a certain time or exceeding a certain time, particularly preferably characterized in that the liquid sample 2 or a component, in particular water, the membrane 12 or another Part of the valve assembly 11 attacks, destroys, dissolves, dissolves and / or otherwise modified.
  • the membrane 12 preferably contains a water-soluble material.
  • the membrane 12 is at least substantially or exclusively made of a water-soluble material.
  • the valve device 11 or membrane 12 can be connected to the drain 5, for example, by gluing, welding, clamping, press-fitting and / or in any other manner, or inserted or introduced into it.
  • the proposed valve device 11 or, in particular, water-soluble membrane 12 can in principle also be used or used for other valve purposes or for the temporary retention of a liquid 2, in particular in a receiving space 4.
  • the valve device 11 or membrane 12 then opens automatically, in particular by at least partially dissolving or dissolving the material or the membrane 12 through the liquid 2 or a component of the liquid 2.
  • the device 1 or its upper part 7, in the illustrated embodiment, preferably has at least one abutment 13, in particular one or more lateral projections or the like, for mounting in a centrifuge or the like (not shown).

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Centrifugal Separators (AREA)

Abstract

L'invention concerne un dispositif et un procédé de séparation d'un résidu surnageant dans un échantillon liquide, un orifice d'écoulement étant fermé par une membrane hydrosoluble qui se dissout après une durée définie de telle manière que le résidu surnageant de l'échantillon est évacué de façon autonome après centrifugation. La membrane hydrosoluble peut également être employée fondamentalement à d'autres fins pour la retenue temporaire d'un liquide dans un espace de réception.
EP12710096.4A 2011-03-24 2012-03-23 Dispositif et procédé de séparation d'un résidu surnageant dans un échantillon liquide et utilisation d'un dispositif soupape comportant une membrane soluble Withdrawn EP2688675A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP12710096.4A EP2688675A1 (fr) 2011-03-24 2012-03-23 Dispositif et procédé de séparation d'un résidu surnageant dans un échantillon liquide et utilisation d'un dispositif soupape comportant une membrane soluble
EP20154836.9A EP3682970A1 (fr) 2011-03-24 2012-03-23 Dispositif de séparation d'un résidu surnageant dans un échantillon liquide

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11002440 2011-03-24
EP12710096.4A EP2688675A1 (fr) 2011-03-24 2012-03-23 Dispositif et procédé de séparation d'un résidu surnageant dans un échantillon liquide et utilisation d'un dispositif soupape comportant une membrane soluble
PCT/EP2012/055218 WO2012127034A1 (fr) 2011-03-24 2012-03-23 Dispositif et procédé de séparation d'un résidu surnageant dans un échantillon liquide et utilisation d'un dispositif soupape comportant une membrane soluble

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP20154836.9A Division EP3682970A1 (fr) 2011-03-24 2012-03-23 Dispositif de séparation d'un résidu surnageant dans un échantillon liquide

Publications (1)

Publication Number Publication Date
EP2688675A1 true EP2688675A1 (fr) 2014-01-29

Family

ID=44652083

Family Applications (2)

Application Number Title Priority Date Filing Date
EP20154836.9A Pending EP3682970A1 (fr) 2011-03-24 2012-03-23 Dispositif de séparation d'un résidu surnageant dans un échantillon liquide
EP12710096.4A Withdrawn EP2688675A1 (fr) 2011-03-24 2012-03-23 Dispositif et procédé de séparation d'un résidu surnageant dans un échantillon liquide et utilisation d'un dispositif soupape comportant une membrane soluble

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP20154836.9A Pending EP3682970A1 (fr) 2011-03-24 2012-03-23 Dispositif de séparation d'un résidu surnageant dans un échantillon liquide

Country Status (4)

Country Link
US (1) US9221049B2 (fr)
EP (2) EP3682970A1 (fr)
JP (1) JP2014508949A (fr)
WO (1) WO2012127034A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9221049B2 (en) 2011-03-24 2015-12-29 Boehringer Ingelheim Microparts Gmbh Device and method for removing a supernatant of a liquid sample, and use of a valve device having a soluble membrane
US9956555B2 (en) 2012-11-30 2018-05-01 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
US10010282B2 (en) 2015-07-24 2018-07-03 Kurin, Inc. Blood sample optimization system and blood contaminant sequestration device and method
US10827964B2 (en) 2017-02-10 2020-11-10 Kurin, Inc. Blood contaminant sequestration device with one-way air valve and air-permeable blood barrier with closure mechanism
WO2020206047A1 (fr) * 2019-04-01 2020-10-08 Kurin, Inc. Dispositif et système d'optimisation d'échantillon de liquide corporel non ventilé
EP4333741A1 (fr) * 2021-05-06 2024-03-13 Covidien LP Systèmes de résection de tissu à composant de gestion de sortie de fluide

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4557274A (en) * 1982-06-07 1985-12-10 Cawood Charles David Midstream urine collector
US4722792A (en) * 1985-02-09 1988-02-02 Kurashiki Boseki Kabushiki Kaisha Filter for centrifugal separator
US5647990A (en) * 1993-05-21 1997-07-15 Vassarotti; Vincenzo Centrifugal method for concentrating macromolecules from a solution and device for carrying out said method
US20020046614A1 (en) * 2000-10-24 2002-04-25 Kenneth Alley Apparatus for sampling and testing a specimen
US20050123456A1 (en) * 2001-12-04 2005-06-09 Lutz Eichacker Device and method for processing biological or chemical substances or substance mixtures thereof
US6946100B2 (en) * 1997-09-16 2005-09-20 Sekisui Chemical Co., Ltd. Blood test container

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1176402B (de) * 1961-11-16 1964-08-20 Martin Christ Fa Zentrifugenzelle
US3897337A (en) * 1974-02-27 1975-07-29 Becton Dickinson Co Plasma separator assembly having interface-seeking piston with centrifugal valve
US3905528A (en) * 1974-04-10 1975-09-16 Hugh V Maiocco Two-piece concentric centrifuge sample container
US4012325A (en) * 1975-01-08 1977-03-15 Eastman Kodak Company Biological fluid dispenser and separator
US4358425A (en) * 1981-02-17 1982-11-09 Beckman Instruments, Inc. Penetrable centrifuge tube
JPS60235035A (ja) * 1984-05-07 1985-11-21 Soji Ishikawa 微量試料の濾過採取方法及び装置
NL8901530A (nl) * 1989-06-16 1991-01-16 Oscar Maria Johannes Driessen Werkwijze alsmede inrichting voor de volumebepaling van deeltjes in een suspensie.
US6153425A (en) * 1995-07-13 2000-11-28 Xtrana, Inc. Self-contained device integrating nucleic acid extraction, amplification and detection
JPH09187269A (ja) * 1996-01-08 1997-07-22 Sanyo Electric Co Ltd 遠心分離機能付き振盪培養機
AU7591998A (en) * 1997-05-23 1998-12-11 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
JP2000056084A (ja) * 1998-08-05 2000-02-25 Toshiba Eng Co Ltd 液体廃棄物処理系沈降分離槽
DE60143424D1 (de) * 2000-03-22 2010-12-23 Dewalch Technologies Inc Verfahren und gerät zur verarbeitung von substanzen in einem einzigen behälter
US7176034B2 (en) * 2002-07-03 2007-02-13 St. Joseph's Healthcare Apparatus and method for filtering biological samples
US6905453B2 (en) * 2003-01-29 2005-06-14 Manfred Grumberg System and method for centrifugal separating of blood components and for sampling therefrom
US20080206751A1 (en) * 2005-01-26 2008-08-28 Enigma Diagnostics Ltd Method For Carrying Out A Multi-Step Reaction, Breakable Container For Storing Reagents And Method For Transferring Solid Reagent Using An Electrostatically Charged Wand
WO2008030607A2 (fr) * 2006-09-08 2008-03-13 Statspin, Inc. Dispositif centrifuge et procédé de détection d'œufs
US7857141B2 (en) * 2006-12-11 2010-12-28 Samsung Electronics Co., Ltd. Apparatus and method for separating components
JP2010099616A (ja) * 2008-10-24 2010-05-06 Olympus Corp 遠心分離容器
WO2011041703A2 (fr) * 2009-10-02 2011-04-07 Life Technologies Corporation Dispositifs et procédés de préparation d'échantillons
US9221049B2 (en) 2011-03-24 2015-12-29 Boehringer Ingelheim Microparts Gmbh Device and method for removing a supernatant of a liquid sample, and use of a valve device having a soluble membrane

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4557274A (en) * 1982-06-07 1985-12-10 Cawood Charles David Midstream urine collector
US4722792A (en) * 1985-02-09 1988-02-02 Kurashiki Boseki Kabushiki Kaisha Filter for centrifugal separator
US5647990A (en) * 1993-05-21 1997-07-15 Vassarotti; Vincenzo Centrifugal method for concentrating macromolecules from a solution and device for carrying out said method
US6946100B2 (en) * 1997-09-16 2005-09-20 Sekisui Chemical Co., Ltd. Blood test container
US20020046614A1 (en) * 2000-10-24 2002-04-25 Kenneth Alley Apparatus for sampling and testing a specimen
US20050123456A1 (en) * 2001-12-04 2005-06-09 Lutz Eichacker Device and method for processing biological or chemical substances or substance mixtures thereof

Also Published As

Publication number Publication date
JP2014508949A (ja) 2014-04-10
EP3682970A1 (fr) 2020-07-22
US20140112841A1 (en) 2014-04-24
US9221049B2 (en) 2015-12-29
WO2012127034A1 (fr) 2012-09-27

Similar Documents

Publication Publication Date Title
EP2353625B1 (fr) Dispositif de séparation de cellules tissulaires à partir d'un liquide
EP2688675A1 (fr) Dispositif et procédé de séparation d'un résidu surnageant dans un échantillon liquide et utilisation d'un dispositif soupape comportant une membrane soluble
DE3632303C2 (de) Verfahren zum Gewinnen von menschlichem Speichel
DE102009040525B4 (de) Zentrifuge zum Trennen von Vollblut in Blutkomponenten, sowie fluidisch kommunizierende Behälter zum Einsetzen in die Zentrifuge, sowie Verfahren zur Gewinnung eines hochangereichten Thrombozytenkonzentrats aus Vollblut
EP1768720B1 (fr) Systeme sterile ferme et procede pour filtrer des liquides biologiques ou medicaux, notamment le sang total
DE2751503A1 (de) Kapillargefaess
EP3579972A1 (fr) Tube médical
WO2006094752A1 (fr) Dispositif de piegeage de bulles d'air veineux
EP3581154B1 (fr) Dispositif de filtration pour un système d'aspiration chirurgicale et procédé de production d'un substitut osseux pourvu de composants de tissu autologues
DE102019121723A1 (de) Trennkörper und Verfahren zum Trennen von Blutplasma und Blutzellen
DE102010001292B4 (de) Vorrichtung zum Trennen von Gewebezellen aus einer Flüssigkeit
DE2415618C3 (de) Filtervorrichtung zum Trennen von Blutfraktionen
EP2331228B1 (fr) Dispositif de vidange
EP2468378B1 (fr) Dispositif de filtre
DE102005048696B4 (de) Behälter mit Filtereinsatz
DE102021206223A1 (de) Gefäß und Verfahren zur Abtrennung von Blutplasma aus Blut über Zentrifugation
WO2017025506A1 (fr) Tube médical
DE102017127969B3 (de) Anschlusseinrichtung für eine Absaugvorrichtung
WO2020099475A2 (fr) Dispositif et procédé pour obtenir une fraction d'échantillon acellulaire
DE3132160C2 (de) Blutentnahmegerät
DE202023104370U1 (de) Vorrichtung zur Abfüllung von Blutprodukten
DE10110512C1 (de) Einsatz für Zentrifugenbecher
DE202022101388U1 (de) Vorrichtung zum Abscheiden von Getränkesatz und dessen Verwendung
DE202020102006U1 (de) Anschwemmfilter
DE102009053823A1 (de) Verbindungsvorrichtung mit perforierbarer Barriere

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20131024

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAX Request for extension of the european patent (deleted)
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20170203

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20200723

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20201203