EP2573072A4 - Indenochinolinverbindung, herstellungsverfahren und anwendung davon - Google Patents
Indenochinolinverbindung, herstellungsverfahren und anwendung davonInfo
- Publication number
- EP2573072A4 EP2573072A4 EP11782937.4A EP11782937A EP2573072A4 EP 2573072 A4 EP2573072 A4 EP 2573072A4 EP 11782937 A EP11782937 A EP 11782937A EP 2573072 A4 EP2573072 A4 EP 2573072A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- indenoquinolone
- compound
- preparation
- indenoquinolone compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201010176288XA CN102250000A (zh) | 2010-05-17 | 2010-05-17 | 茚并喹啉酮类化合物及其制备方法和用途 |
PCT/CN2011/074203 WO2011144020A1 (zh) | 2010-05-17 | 2011-05-17 | 茚并喹啉酮类化合物及其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2573072A1 EP2573072A1 (de) | 2013-03-27 |
EP2573072A4 true EP2573072A4 (de) | 2013-11-13 |
Family
ID=44977612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11782937.4A Withdrawn EP2573072A4 (de) | 2010-05-17 | 2011-05-17 | Indenochinolinverbindung, herstellungsverfahren und anwendung davon |
Country Status (4)
Country | Link |
---|---|
US (1) | US9181193B2 (de) |
EP (1) | EP2573072A4 (de) |
CN (2) | CN102250000A (de) |
WO (1) | WO2011144020A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102993018B (zh) * | 2012-08-10 | 2015-08-05 | 浙江工业大学 | 一种5-硝基咖啡酸金刚醇酯及其在制备抗肿瘤药物中的应用 |
US20150197492A1 (en) * | 2014-01-13 | 2015-07-16 | National Defense Medical Center | NOVEL INDENO[1,2-c]QUINOLIN-11-ONE DERIVATIVES, PREPARATION METHOD AND APPLICATION THEREOF |
US8927717B1 (en) * | 2014-02-14 | 2015-01-06 | National Defense Medical Center | Thiochromeno[2,3-c]quinolin-12-one derivatives, preparation method and application thereof |
CN105175334A (zh) * | 2014-06-10 | 2015-12-23 | 中国人民解放军第二军医大学 | 6-烷氧基茚并喹啉酮类化合物及其制备方法和用途 |
CN105175333A (zh) * | 2014-06-10 | 2015-12-23 | 中国人民解放军第二军医大学 | 5H-茚并[1,2-c]喹啉-6,11-二酮类化合物及其制备方法和用途 |
CN106279021A (zh) * | 2015-05-19 | 2017-01-04 | 中国人民解放军第二军医大学 | 一类基于茚并喹啉酮骨架的组蛋白去乙酰化酶抑制剂及其制备方法和应用 |
CN104926726B (zh) * | 2015-05-19 | 2018-05-01 | 中国人民解放军第二军医大学 | 异羟肟酸类组蛋白去乙酰化酶抑制剂及其制备方法和应用 |
CN105622508B (zh) * | 2015-12-22 | 2018-08-21 | 广西师范大学 | 一种新的[1,2,b]茚并喹啉类衍生物及其制备方法和在抗肿瘤药物中的应用 |
CN108690036B (zh) * | 2018-05-22 | 2021-05-25 | 北京海步医药科技股份有限公司 | 一种10-二氟甲基喜树碱类化合物及其制备方法和应用 |
CN113861113B (zh) * | 2021-09-14 | 2022-12-06 | 中国科学院福建物质结构研究所 | 一种稠环吡啶化合物及其衍生物的制备和应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09143166A (ja) * | 1995-11-17 | 1997-06-03 | Taiho Yakuhin Kogyo Kk | 新規な縮合インダン誘導体及びその塩 |
WO2004014862A1 (en) * | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted heterocycles as topoisomerase i targeting agents |
WO2007059008A2 (en) * | 2005-11-14 | 2007-05-24 | Purdue Research Foundation | N-substituted indenoisoquinolines and syntheses thereof |
US20090111987A1 (en) * | 2007-10-31 | 2009-04-30 | Kaohsiung Medical University | Imino-Indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same |
CN101565402A (zh) * | 2009-05-19 | 2009-10-28 | 中国药科大学 | 茚并异喹啉酮化合物、其制备方法及医药用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0780138B2 (ja) | 1989-07-05 | 1995-08-30 | 宮川工機株式会社 | スミ付け装置を備えた切断装置 |
SK266991A3 (en) * | 1991-08-29 | 1998-03-04 | Vufb As | 2-hydroxyethylaminosubstituted derivatives of 5,11-dioxo-5,6- -dihydro-11h-indeno£1,2-c|isoquinoline, a process for manufacture thereof and pharmaceutical composition containing the same |
EP1603567A4 (de) * | 2003-02-28 | 2006-10-18 | Inotek Pharmaceuticals Corp | Tetracyclische benzamid-derivate und anwendungsverfahren dafür |
-
2010
- 2010-05-17 CN CN201010176288XA patent/CN102250000A/zh active Pending
-
2011
- 2011-05-17 US US13/698,739 patent/US9181193B2/en not_active Expired - Fee Related
- 2011-05-17 WO PCT/CN2011/074203 patent/WO2011144020A1/zh active Application Filing
- 2011-05-17 EP EP11782937.4A patent/EP2573072A4/de not_active Withdrawn
- 2011-05-17 CN CN201180024535.7A patent/CN102947273B/zh not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09143166A (ja) * | 1995-11-17 | 1997-06-03 | Taiho Yakuhin Kogyo Kk | 新規な縮合インダン誘導体及びその塩 |
WO2004014862A1 (en) * | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted heterocycles as topoisomerase i targeting agents |
WO2007059008A2 (en) * | 2005-11-14 | 2007-05-24 | Purdue Research Foundation | N-substituted indenoisoquinolines and syntheses thereof |
US20090111987A1 (en) * | 2007-10-31 | 2009-04-30 | Kaohsiung Medical University | Imino-Indeno[1,2-c] quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same |
CN101565402A (zh) * | 2009-05-19 | 2009-10-28 | 中国药科大学 | 茚并异喹啉酮化合物、其制备方法及医药用途 |
Non-Patent Citations (3)
Title |
---|
See also references of WO2011144020A1 * |
TSENG C H ET AL: "Synthesis and antiproliferative evaluation of 6-arylindeno[1,2-c]quinoline derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 17, no. 21, 16 September 2009 (2009-09-16), pages 7465 - 7476, XP026691222, ISSN: 0968-0896, [retrieved on 20090916], DOI: 10.1016/J.BMC.2009.09.021 * |
TSENG ET AL: "Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 16, no. 6, 23 December 2007 (2007-12-23), pages 3153 - 3162, XP022558549, ISSN: 0968-0896, DOI: 10.1016/J.BMC.2007.12.028 * |
Also Published As
Publication number | Publication date |
---|---|
CN102250000A (zh) | 2011-11-23 |
WO2011144020A1 (zh) | 2011-11-24 |
CN102947273A (zh) | 2013-02-27 |
US20130102598A1 (en) | 2013-04-25 |
US9181193B2 (en) | 2015-11-10 |
CN102947273B (zh) | 2016-05-04 |
EP2573072A1 (de) | 2013-03-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20121217 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20131011 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 35/00 20060101ALI20131007BHEP Ipc: C07D 401/12 20060101ALI20131007BHEP Ipc: C07D 221/18 20060101AFI20131007BHEP Ipc: A61K 31/473 20060101ALI20131007BHEP Ipc: C07D 401/06 20060101ALI20131007BHEP |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: SONG, YUNLONG Inventor name: FU, XIAODAN Inventor name: QI, YUNPENG Inventor name: POMMIER, YVES G. |
|
17Q | First examination report despatched |
Effective date: 20141124 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
INTG | Intention to grant announced |
Effective date: 20160421 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20160902 |