EP2511183B1 - Ensemble et procédé d'actionnement de seringue - Google Patents

Ensemble et procédé d'actionnement de seringue Download PDF

Info

Publication number
EP2511183B1
EP2511183B1 EP20120161130 EP12161130A EP2511183B1 EP 2511183 B1 EP2511183 B1 EP 2511183B1 EP 20120161130 EP20120161130 EP 20120161130 EP 12161130 A EP12161130 A EP 12161130A EP 2511183 B1 EP2511183 B1 EP 2511183B1
Authority
EP
European Patent Office
Prior art keywords
claw
cylinder
syringe
piston
itself
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP20120161130
Other languages
German (de)
English (en)
Other versions
EP2511183A1 (fr
Inventor
Paolo Giribona
Walter Bianco
Michele Minisini
Garcia Gaspar De Viedma Santoro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aesynt Topco BV
Original Assignee
Aesynt Topco BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aesynt Topco BV filed Critical Aesynt Topco BV
Publication of EP2511183A1 publication Critical patent/EP2511183A1/fr
Application granted granted Critical
Publication of EP2511183B1 publication Critical patent/EP2511183B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • G—PHYSICS
    • G07—CHECKING-DEVICES
    • G07F—COIN-FREED OR LIKE APPARATUS
    • G07F17/00—Coin-freed apparatus for hiring articles; Coin-freed facilities or services
    • G07F17/0092—Coin-freed apparatus for hiring articles; Coin-freed facilities or services for assembling and dispensing of pharmaceutical articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B43/00—Forming, feeding, opening or setting-up containers or receptacles in association with packaging
    • B65B43/42—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation
    • B65B43/46—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation using grippers

Definitions

  • the present invention relates to a syringe actuating assembly.
  • a machine in the pharmaceutical product preparation field, comprising a store for storing syringes, each of which has a cylinder and a piston slidingly engaged in the cylinder itself; a store for storing bottles; a store for storing infusion bags; a dosing station for the preparation of a pharmaceutical product obtained by mixing together at least one pharmaceutical substance contained in a bottle and at least one diluent contained in an infusion bag; and a robotized gripping and transporting arm for transferring syringes and bottles between the dosing station and the corresponding stores.
  • the dosing station is generally provided with an actuating assembly comprising two gripping devices of the syringe cylinder and piston, respectively, and an actuating device for moving the two gripping devices with respect to each other in a direction parallel to a longitudinal axis of the syringe itself.
  • the known actuating assemblies of the above-described type have several drawbacks, mainly deriving from that such actuating assemblies are not able to ensure the correct initial position of the cylinder in the corresponding gripping device and the correct initial position of the piston along the cylinder itself, and may compromise the correct operation of dosing the pharmaceutical products into the syringes and/or infusion bags.
  • Document WO2009/147252 discloses an automated workstation for the preparation of a final product for medical or pharmaceutical use from different substances.
  • the final product is packaged in a container, while each substance is contained in a vessel.
  • the workstation comprises an isolated chamber which delimits different internal functional areas.
  • the isolated chamber delimits a loading area comprising rapid decontamination means, a lock device for introducing the vessels and containers into the loading area and for unloading the final products from the workstation, a storage area for storing the filled vessels and containers which communicates with the loading area, a transfer area, a preparation area for preparing the final products which communicates with the storage area via the transfer area, and one robot for handling the objects contained in the storage area and/or in the preparation area.
  • a syringe actuating assembly is provided as claimed in claims from 1 to 5.
  • the present invention further relates to a method of actuating a syringe.
  • numeral 1 indicates as a whole a machine for the preparation of pharmaceutical products, comprising a box-like containment frame 2 having a substantially parallelepiped shape and defining an inner chamber 3, which is kept under substantially sterile conditions by a pneumatic device of known type, shaped so as to feed a flow of sterile air through chamber 3 and prevent the introduction of air from the external environment into chamber 3.
  • Chamber 3 accommodates a store 4 therein for storing syringes 5; a store 6 for storing bottles 7; an annular store 8 for storing infusion bags 9; and a robotized device 10 for gripping and transporting syringes 5 and/or bottles 7.
  • Each syringe 5 ( figure 3 ) has a longitudinal axis 11, and comprises a cylinder 12 provided with an end flange 13 orthogonal to axis 11, a needle (not shown) coupled to cylinder 12, a closing cap 14 mounted to protect the needle (not shown) from possible contaminations, and a piston 15, which is slidingly engaged in cylinder 12, and is provided with an end head 16 perpendicular to axis 11.
  • Each bag 9 is provided with an adapter member 17 of known type, which comprises two shaped jaws 18 movable between a clamping position and a releasing position of an upper edge of bag 9, and has a drawing pin 19 protruding upwards from one of the jaws 18 ( figure 5 ).
  • device 10 is mounted within store 8, comprises a plurality of articulated arms 20 hinged to one another, and is provided with a gripping claw 21, which is mounted to the free end of the arms 20, and is defined by two jaws 22 movable between a clamping position and a releasing position of a syringe 5 or a bottle 7.
  • each store 4, 6 comprises two reciprocally parallel belt conveyors 23, each of which extends in a substantially vertical direction A, faces the other conveyor 23, and is looped about a pair of pulleys (not shown), which are coaxial with the pulleys (not shown) of the other conveyor 23, and are mounted so as to intermittently rotate about respective horizontal rotation axis 24 parallel to one another and transversal to direction A.
  • Each store 4, 6 further comprises a plurality of transport cradles 25, which extend between the conveyors 23, are coupled to the conveyors 23 to oscillate, with respect to conveyors 23, about respective horizontal fulcrum axes 26 parallel to one another and to axes 24, and which are uniformly distributed along the conveyors 23 themselves.
  • each cradle 25 of store 4 (hereinafter indicated by numeral 25a) has a substantially V-shaped transversal section, is arranged with a longitudinal axis 27a thereof parallel to axes 24, 26, is provided with a first slot 28 adapted to receive the flange 13 of a syringe 5 to ensure the correct longitudinal positioning of syringe 5 into cradle 25a, and furthermore has a second slot 29 adapted to be engaged by the jaws 22 to allow device 10 to collect the syringe 5 from the cradle 25a itself.
  • each cradle 25 of store 6 (hereinafter indicated by numeral 25b) has a substantially V-shaped transversal section, is arranged with a longitudinal axis thereof 27b inclined with respect to axis 24, 26, and is provided with a slot 30, which is obtained close to the lower end of cradle 25b, allows to correctly place a bottle 7 with its concavity facing downwards, and allows the jaws 22 to collect the bottle 7 itself.
  • each store 4 6 extends through a loading station obtained through frame 2 to allow the operator to load the syringes 5 or bottles 7 into the respective cradles 25a, 25b, and through a single collecting station, where the syringes 5 or bottles 7 are collected from the respective cradles 25a, 25b by means of device 10, the device 10 is relatively simple and cost-effective. Furthermore, the loading and unloading of syringes 5 and bottles 7 into, and respectively from, the corresponding cradles 25a, 25b does not require machine 1 to be stopped.
  • store 8 comprises an star-like wheel 31 having an annular shape, which extends about the device 10, is mounted to rotate intermittently, with respect to frame 2 and under the bias of an actuating device (known and not shown), about a substantially vertical rotation axis 32, and has a plurality of pockets 33, which are obtained along a peripheral edge of wheel 31, are open radially outwards and are each adapted to receive and hold a respective infusion bag 9.
  • the pockets 33 are fed by wheel 31 about axis 32 and along a circular path P extending through a loading and unloading station 34 of the bags 8 into, and respectively from, store 8, a weighing station 35 of bags 9, and a dosing station 36 for injecting a predetermined amount of pharmaceutical product into the bags 9 themselves.
  • Each station 34, 35, 36 is provided with a linear transfer device 37 comprising a rectilinear guide 38 parallel to a horizontal direction 39 transversal to axis 32, a slide 40 slidingly coupled to the guide 38 to perform rectilinear movements along guide 38 in direction 39, and a gripping fork 41 slidingly coupled to slide 40 to move, with respect to the slide 40 and transversally to direction 39, between a coupling position and a releasing position of the pin 19 of a corresponding adapter member 17.
  • a linear transfer device 37 comprising a rectilinear guide 38 parallel to a horizontal direction 39 transversal to axis 32, a slide 40 slidingly coupled to the guide 38 to perform rectilinear movements along guide 38 in direction 39, and a gripping fork 41 slidingly coupled to slide 40 to move, with respect to the slide 40 and transversally to direction 39, between a coupling position and a releasing position of the pin 19 of a corresponding adapter member 17.
  • Device 37 of station 34 cooperates with a guide 42, which is parallel to the corresponding guide 38, is radially aligned with pocket 33 arranged each time in the station 34 to be slidingly engaged by the member 17 of a respective bag 9, and extends between store 8 and an opening 43 obtained through frame 2 to allow an operator to load the bags 9 on the guide 42 and to collect the bags 9 from the guide 42 itself.
  • the device 37 of station 35 cooperates with a weighing device 44 comprising a movable supporting member 45, which is coupled in a known manner to a fixed part of the device 44 to vertically move under the weight of the bags 9, is fork-shaped, and defines a guide 46 radially aligned with the pocket 33 arranged each time in station 35 to be slidingly engaged by the member 17 of a corresponding bag 9.
  • the device 37 of station 36 cooperates with a guide (not shown), which is parallel to the corresponding guide 38, is radially aligned with the pocket 33 arranged each time in station 36 to be slidingly engaged by the member 17 of a corresponding bag 9, and is adapted to stop the bag 9 itself underneath a syringe 5, which is transferred from device 10 between store 4 and a gripping and actuating assembly 47 of the syringe 5 itself.
  • a guide (not shown), which is parallel to the corresponding guide 38, is radially aligned with the pocket 33 arranged each time in station 36 to be slidingly engaged by the member 17 of a corresponding bag 9, and is adapted to stop the bag 9 itself underneath a syringe 5, which is transferred from device 10 between store 4 and a gripping and actuating assembly 47 of the syringe 5 itself.
  • assembly 47 comprises a supporting block 48, which is mounted to rotate about a horizontal rotation axis 49 transversal to axis 32, and supports a gripping device 50 of cylinder 12 and a gripping device 51 of piston 15.
  • Device 50 comprises two claws 52, which are aligned to each other in a direction 53, the orientation of which depends on the position of the block 48 about axis 49, and each comprise two respective jaws 54, which are slidingly coupled to the block 48 in order to move, with respect to the block 48 itself, transversally to direction 53, and are normally kept in a clamping position of the cylinder 12 by respective springs 55 interposed between block 48 and jaws 54, and loaded so as to allow the axial movement of syringe 5 through the claws 52.
  • Device 50 further comprises an intermediate claw 56, which extends between the claws 52, and comprises, in turn, two jaws 57 slidingly coupled to the block 48 in order to move with respect to block 48 and under the bias of an actuating device (known and not shown), transversally to direction 53 between a clamping position and a releasing position of the cylinder 12 of a syringe 5.
  • an actuating device known and not shown
  • the jaws 57 are shaped so as to allow one of the jaws 57 to be inserted into the other jaw 57 and also to clamp syringes 5 of relatively small diameter.
  • Device 51 comprises two jaws 58, which are slidingly coupled to the block 48 in order to move with respect to block 48 and under the bias of an actuating device (known and not shown), transversally to direction 53 between a clamping position and a releasing position of the head 16 of a syringe 5, and are further slidingly coupled to block 48 in order to perform rectilinear movements in direction 53 itself with respect to block 48 and under the bias of an actuating device (known and not shown).
  • Each jaw 58 has a plurality of grooves 59 (two grooves 59, in this case) reciprocally overlapping in direction 53 to allow device 51 to receive and hold the heads 16 of syringes 5 of different size.
  • assembly 47 will now be described starting from when jaws 57 and jaws 58 are arranged in their releasing positions, and syringe 5 is inserted by means of the device 10 into the jaws 54 against the bias of the springs 55.
  • the jaws 58 are firstly closed over head 16 and then lowered in direction 53 so as to move the syringe 5 through the claws 52, arrange the flange 13 in contact with the upper claw 52 and, possibly, push piston 15 fully into cylinder 12.
  • the above-described operating sequence allows to correctly place syringe 5 in direction 53 while ensuring a correct, constant positioning of all syringe 5 regardless of the size thereof, of the initial position of pistons 15 along the corresponding cylinders 12, and of the initial axial, angular positions of syringes 5 within the claws 52.
  • jaws 57 are moved to their clamping position of syringe 5 within assembly 47, and the jaws 58 are moved to their clamping position of head 16 to control the movement of piston 15 during the steps of aspirating and injecting the pharmaceutical.
  • machine 1 further comprises a mixer device 60 for mixing together a lyophilized or powder pharmaceutical and a diluent contained in a bottle 7.
  • Device 60 comprises a rotating plate 61, which is mounted to alternatively rotate about a substantially horizontal rotation axis 62, and is provided with a pair of jaws 63 coupled in a known manner to plate 61 in order to move, with respect to plate 61, transversally to axis 62, between a clamping position and a releasing position of a bottle 7.
  • Each jaw 63 is shaped so as to have, in this case, a pair of seats 64, which cooperate with the corresponding seats 64 of the other jaw 63 to allow the jaws 63 to hold bottles 7 of different size.
  • path P further extends through a collecting station 65 of a predetermined amount of liquid from bags 9.
  • the liquid of bag 9 is necessarily collected when the overall weight of pharmaceutical and diluent contained in bag 9 once the pharmaceutical has been injected needs to be equal to a determined value lower than the weight of the sole diluent first contained in bag 9.
  • Station 65 has an aspiration assembly 66 comprising a gripping device 67 adapted to receive and hold an extraction needle 68, which is connected to a hydraulic aspiration circuit 69, is transferred by device 10 into device 67 once it has been separated from a protective cap thereof (known and not shown), and is moved by device 67 in direction A between a raised resting position, in which needle 68 is arranged outside bag 9, and a lowered operating position, in which needle 68 protrudes within bag 9 over the diluent contained in the bag 9 itself.
  • an aspiration assembly 66 comprising a gripping device 67 adapted to receive and hold an extraction needle 68, which is connected to a hydraulic aspiration circuit 69, is transferred by device 10 into device 67 once it has been separated from a protective cap thereof (known and not shown), and is moved by device 67 in direction A between a raised resting position, in which needle 68 is arranged outside bag 9, and a lowered operating position, in which needle 68 protrudes within bag 9 over the
  • Circuit 69 comprises an extraction pump 70, in this case a peristaltic pump, having an inlet hydraulically connected to needle 68 by means of a first pipe 71, and an outlet hydraulically connected to a collection reservoir 72 of the diluent collected from bags 9 by means of a second pipe 73.
  • extraction pump 70 in this case a peristaltic pump, having an inlet hydraulically connected to needle 68 by means of a first pipe 71, and an outlet hydraulically connected to a collection reservoir 72 of the diluent collected from bags 9 by means of a second pipe 73.
  • pipe 71 is provided with a flow sensor 74, a capacitance sensor in this case, which allows to discriminate between the passage of air and of liquid along pipe 71, and thus correctly calculate the volume of liquid aspirated from the bags 9 by means of pump 70.
  • the volume of liquid aspirated from the bags 9 is calculated only starting from when sensor 74 detects the passage of liquid along pipe 71.
  • machine 1 further comprises a feeding device 75 to feed a diluent into a bottle 7 containing a lyophilized or powder pharmaceutical.
  • device 75 comprises two feeding assemblies 76, each of which comprises, in turn, a feeding reservoir 77 (e.g. a bag 9) for the diluent; a feeding needle 78 coupled to frame 2 and hydraulically connected to reservoir 77 by means of a pipe 79; and a pumping device defined, in this case, by a syringe 80, which is connected to an intermediate point of pipe 79, and is actuated in a known manner to aspirate a predetermined amount of diluent from reservoir 77 and to feed the diluent itself into bottle 7.
  • a feeding reservoir 77 e.g. a bag 9
  • a feeding needle 78 coupled to frame 2 and hydraulically connected to reservoir 77 by means of a pipe 79
  • a pumping device defined, in this case, by a syringe 80, which is connected to an intermediate point of pipe 79, and is actuated in a known manner to aspirate a predetermined amount of diluent from reservoir 77 and
  • connection between pipe 79 and syringe 80 divides pipe 79 into two segments 79a, 79b, which are arranged in sequence and in the order between reservoir 77 and needle 78, and which are provided with respective check valves 81a, 81b, valve 81a of which avoids the flow back of diluent into segment 79a when diluent is fed to needle 78, and valve 81b avoids the flow back of the diluent from segment 79b when the diluent is aspirated from reservoir 77.
  • Device 75 further comprises a collection tank 82, which extends underneath the needles 78, is coupled in a known manner to frame 2 in order to move with respect to the frame 2, in direction A between a lowered resting position ( figure 13b ) and a raised operating position ( figure 13a ), and is hydraulically connected to a collection manifold 83 of the diluent.
  • Tank 82 further has a pair of tubes 84, each of which protrudes upwards from a bottom wall of tank 82, is substantially coaxial to the corresponding needle 78, and accommodates therein a protective cap 85 of the needle 78 itself arranged in the tube 84 with the concavity facing upwards.
  • tank 82 In use, tank 82 is moved, along with the caps 85 of the needles 78, to its lowered resting position to allow two bottles 7 to be inserted underneath the needles 78 and the diluent to be fed into the bottles 7 themselves.
  • the needles When the needles are extracted from the corresponding bottles 7, they may have residues of the lyophilized or powder pharmaceutical contained in the bottles 7 themselves, and at the end of each injection operating cycle of the feeding device 75, the tank 82 is moved to its raised operating position so as to fit the caps 85 on the corresponding needles 78, and the syringes 80 are actuated to allow needles 78 to be washed with the diluent contained in the reservoirs 77.
  • machine 1 is further provided with a collection device 86 of the processing waste (e.g. syringes 5, bottle 7, needles 78, and caps 85) accommodated within frame 2 underneath store 8, and comprising, in this case, two collection containers 87, one of which (hereinafter indicated by numeral 87a) communicates with chamber 3 by means of a pair of chutes 88, while the other (hereinafter indicated by numeral 87b) communicates with chamber 3 by means of one chute only 89.
  • a collection container 87 one of which (hereinafter indicated by numeral 87a) communicates with chamber 3 by means of a pair of chutes 88, while the other (hereinafter indicated by numeral 87b) communicates with chamber 3 by means of one chute only 89.
  • the various processing waste is selectively fed by device 10 to the various chutes 88, 89 and, therefore, to the various containers 87a, 87b, thus allowing to separate the processing waste.
  • machine 1 The operation of machine 1 is easily inferred from the above description and no further explanations are required.

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (7)

  1. Ensemble d'actionnement d'une seringue (5) comprenant un cylindre (12) prévu avec une bride externe (13) et un piston (15) mis en prise de manière coulissante à l'intérieur du cylindre (12) lui-même ; l'ensemble d'actionnement comprenant deux dispositifs de préhension (50, 51) du cylindre (12) et du piston (15), respectivement, qui sont mobiles l'un par rapport à l'autre dans une direction (53) parallèle à un axe longitudinal (11) de la seringue (5), le dispositif de préhension (50) du cylindre (12) comprenant au moins une première pince (52) adaptée pour recevoir et maintenir le cylindre (12) lui-même et au moins une deuxième pince (56) mobile entre une position de serrage et une position de libération du cylindre (12) lui-même ; et étant caractérisé en ce que le dispositif de préhension (51) du piston (15) comprend une troisième pince (58) mobile entre une position de serrage et une position de libération d'une tête d'extrémité (16) du piston (15) lui-même et en ce que la troisième pince (58) est en outre mobile à partir de et vers la première pince (52) dans la direction (53) pour alimenter de manière axiale la seringue (5) par le biais de la première pince (52) afin de déplacer la bride (13) en contact avec la première pince (52) et le piston (15) dans une position d'arrêt à l'intérieur du cylindre (12).
  2. Ensemble d'actionnement selon la revendication 1, dans lequel le dispositif de préhension (50) du cylindre (12) comprend en outre des moyens de poussée élastiques (55) adaptés pour maintenir normalement la première pince (52) dans une position de serrage du cylindre (12).
  3. Ensemble d'actionnement selon la revendication 1 ou 2, dans lequel la deuxième pince (56) comprend deux mâchoires (57) formées pour s'interpénétrer mutuellement suite au déplacement de la deuxième pince (56) dans sa position de serrage.
  4. Ensemble d'actionnement selon l'une quelconque des revendications précédentes, dans lequel le dispositif de préhension (50) du cylindre (12) comprend deux desdites premières pinces (52) ; la deuxième pince (56) étant montée entre les deux premières pinces (52) dans ladite direction (53).
  5. Ensemble d'actionnement selon l'une quelconque des revendications précédentes, dans lequel ladite troisième pince (58) a au moins deux sièges (59) adaptés pour recevoir et maintenir les têtes d'extrémité (16) des seringues (5) de différentes tailles.
  6. Procédé pour actionner une seringue (5) pour la préparation d'un produit pharmaceutique, la seringue comprenant un cylindre (12) doté d'une bride externe (13) et d'un piston (15) mis en prise de manière coulissante dans le cylindre (12) lui-même ; le procédé comprenant l'étape consistant à :
    insérer la seringue (5) dans au moins une première pince (52) adaptée pour recevoir et maintenir ledit cylindre (12) ;
    et étant caractérisé en ce qu'il comprend en outre en séquence et dans cet ordre, les étapes consistant à :
    déplacer un dispositif de poussée (51) en contact avec une extrémité de tête (16) du piston (15), le dispositif de poussée (51) comprenant une troisième pince (58) mobile entre une position de serrage et une position de libération de ladite tête d'extrémité (16) ;
    amener le dispositif de poussée (51) dans une direction (53) parallèle à un axe longitudinal (11) de la seringue (5) afin de déplacer la seringue (5) de manière axiale par le biais de la première pince (52) et permettre à la bride (13) d'être agencée en contact avec la première pince (52) et au piston (15) d'être agencé dans une position d'arrêt à l'intérieur du cylindre (12) ;
    serrer la seringue (5) dans au moins une deuxième pince (56) mobile entre une position de serrage et une position de libération du cylindre (12) ;
    serrer la tête d'extrémité (16) à l'intérieur de la troisième pince (58) une fois que la bride (13) a été déplacée en contact avec la première pince (52) et que le piston (15) a été déplacé dans ladite position d'arrêt ; et
    déplacer la troisième pince (58) dans ladite direction (53) pour actionner la seringue (5).
  7. Procédé selon la revendication 6 et comprenant en outre l'étape consistant à :
    maintenir normalement la première pince (52) dans une position de serrage du cylindre (12) au moyen des moyens de poussée élastiques (55).
EP20120161130 2011-03-23 2012-03-23 Ensemble et procédé d'actionnement de seringue Active EP2511183B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000148A ITBO20110148A1 (it) 2011-03-23 2011-03-23 Metodo e gruppo di azionamento di una siringa

Publications (2)

Publication Number Publication Date
EP2511183A1 EP2511183A1 (fr) 2012-10-17
EP2511183B1 true EP2511183B1 (fr) 2015-03-04

Family

ID=43976875

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20120161130 Active EP2511183B1 (fr) 2011-03-23 2012-03-23 Ensemble et procédé d'actionnement de seringue

Country Status (3)

Country Link
EP (1) EP2511183B1 (fr)
ES (1) ES2535277T3 (fr)
IT (1) ITBO20110148A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI126653B (fi) 2013-11-08 2017-03-31 Newlcon Oy Menetelmä ja laitteisto lääkeruiskun käyttämiseksi sekä lääkeaineen liuottamiseksi nesteeseen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2323674A1 (de) * 1973-05-10 1974-11-28 Loesch Gmbh Maschf Selbstzentrierender halter an fuell- und verschliessmaschinen
WO2009033283A1 (fr) * 2007-09-12 2009-03-19 Intelligent Hospital Systems Ltd. Dispositif de préhension
FR2932085B1 (fr) * 2008-06-06 2012-08-10 Pharmed Sam Station de travail automatisee pour la preparation securisee d'un produit final a usage medical ou pharmaceutique

Also Published As

Publication number Publication date
EP2511183A1 (fr) 2012-10-17
ITBO20110148A1 (it) 2012-09-24
ES2535277T3 (es) 2015-05-07

Similar Documents

Publication Publication Date Title
CA2721658C (fr) Methode et assemblage pour commander une seringue
CA2721652C (fr) Appareil pour la production de produits pharmaceutiques
CA2721656C (fr) Appareil pour la production de produits pharmaceutiques
CA2721628C (fr) Methode de production de produits pharmaceutiques
EP2054145B1 (fr) Dispositif conçue pour la préparation de produits pharmaceutiques
CA2721645C (fr) Methode et appareil pour la preparation de produits pharmaceutiques
US20120048424A1 (en) Method and Machine for the Preparation of Pharmaceutical Products
EP2502610B1 (fr) Méthode de préparation de produits pharmaceutiques
CN101511461A (zh) 用于制备药物的机器
EP2511183B1 (fr) Ensemble et procédé d'actionnement de seringue
EP2502669B1 (fr) Machine de préparation de produits pharmaceutiques
EP2502670B1 (fr) Machine de préparation de produits pharmaceutiques

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

17P Request for examination filed

Effective date: 20130417

17Q First examination report despatched

Effective date: 20130513

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: AESYNT TOPCO B.V.

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTG Intention to grant announced

Effective date: 20140922

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 713615

Country of ref document: AT

Kind code of ref document: T

Effective date: 20150415

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602012005474

Country of ref document: DE

Effective date: 20150416

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2535277

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20150507

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 713615

Country of ref document: AT

Kind code of ref document: T

Effective date: 20150304

Ref country code: NL

Ref legal event code: VDEP

Effective date: 20150304

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150604

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150605

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150706

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150704

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602012005474

Country of ref document: DE

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150331

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150323

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150331

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

26N No opposition filed

Effective date: 20151207

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 5

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 6

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20120323

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20150323

REG Reference to a national code

Ref country code: FR

Ref legal event code: PLFP

Year of fee payment: 7

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150304

REG Reference to a national code

Ref country code: DE

Ref legal event code: R081

Ref document number: 602012005474

Country of ref document: DE

Owner name: OMNICELL, INC. (N. D. GES. D. STAATES DELAWARE, US

Free format text: FORMER OWNER: AESYNT TOPCO B.V., AMSTERDAM, NL

Ref country code: DE

Ref legal event code: R082

Ref document number: 602012005474

Country of ref document: DE

Representative=s name: ISARPATENT - PATENT- UND RECHTSANWAELTE BARTH , DE

REG Reference to a national code

Ref country code: DE

Ref legal event code: R081

Ref document number: 602012005474

Country of ref document: DE

Owner name: OMNICELL, INC. (N. D. GES. D. STAATES DELAWARE, US

Free format text: FORMER OWNER: AESYNT B.V., AMSTERDAM, NL

Ref country code: DE

Ref legal event code: R082

Ref document number: 602012005474

Country of ref document: DE

Representative=s name: ISARPATENT - PATENT- UND RECHTSANWAELTE BARTH , DE

REG Reference to a national code

Ref country code: GB

Ref legal event code: 732E

Free format text: REGISTERED BETWEEN 20200702 AND 20200708

Ref country code: ES

Ref legal event code: PC2A

Owner name: OMNICELL, INC.

Effective date: 20200723

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20230221

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: TR

Payment date: 20230322

Year of fee payment: 12

Ref country code: IT

Payment date: 20230228

Year of fee payment: 12

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230527

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: ES

Payment date: 20230405

Year of fee payment: 12

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: DE

Payment date: 20240227

Year of fee payment: 13

Ref country code: GB

Payment date: 20240222

Year of fee payment: 13