EP2463205A1 - Automated device for preparing batches of products, from blister-packed products, in particular drugs - Google Patents

Automated device for preparing batches of products, from blister-packed products, in particular drugs Download PDF

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Publication number
EP2463205A1
EP2463205A1 EP11306624A EP11306624A EP2463205A1 EP 2463205 A1 EP2463205 A1 EP 2463205A1 EP 11306624 A EP11306624 A EP 11306624A EP 11306624 A EP11306624 A EP 11306624A EP 2463205 A1 EP2463205 A1 EP 2463205A1
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EP
European Patent Office
Prior art keywords
blister
extraction
products
positioning
product
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Granted
Application number
EP11306624A
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German (de)
French (fr)
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EP2463205B1 (en
Inventor
Michel Mathis
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Mathis Technologies
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Mathis Technologies
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Publication of EP2463205B1 publication Critical patent/EP2463205B1/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B69/00—Unpacking of articles or materials, not otherwise provided for
    • B65B69/005—Unpacking of articles or materials, not otherwise provided for by expelling contents, e.g. by squeezing the container
    • B65B69/0058—Solid contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
    • B65B5/10—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles
    • B65B5/101—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity
    • B65B5/103—Filling containers or receptacles progressively or in stages by introducing successive articles, or layers of articles by gravity for packaging pills or tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B2220/00—Specific aspects of the packaging operation
    • B65B2220/14—Adding more than one type of material or article to the same package

Definitions

  • the present invention relates to an automated device for preparing batches of products, from such products packaged in blisters, in particular for the preparation of individual batches of drugs (or the like) for a patient.
  • the number, shape and distribution of the packaging compartments are specific to each drug and therefore there is a very wide variety of packaging blisters.
  • the person responsible for the preparation of such batches of drugs must extract the desired tablet by degradation of its compartment, and it must distribute the various drugs extracted in individual containers of the kind pill (s) in particular.
  • WO-98/29084 also describes an automated device for the preparation of batches of products such as drugs, from products packaged in blisters.
  • the blisters are stacked on each other in inboxes each equipped with an identification system.
  • a unit of movement allows the management of the lowest blister of the stack, to extract it from this stack and position it correctly to allow the extraction of one of the products of its packaging compartment, via a mobile extraction unit.
  • a container placed under this mobile extraction unit ensures the receipt of the product extracted from its compartment.
  • the present invention aims to overcome these disadvantages by providing an automated system for preparing individual batches of drugs (or the like) from drugs packaged in blisters, each of these blisters being associated with a particular carrier, consisting of a association base / lid and having its own means of identification.
  • said base and said cover being adapted to take said sandwich blister, with their openings in correspondence and placed opposite one or more of said compartments of said blister, to ensure the maintenance of the latter and prevent its deformations during product extraction phases.
  • each support comprises identification means capable of cooperating with detection means, in particular for the management of the positioning and implementation of said extraction means by said electronic / computer means.
  • each blister between its base and its receiving cover ensures its proper maintenance for its movements and product extraction operations.
  • the base supports the underside of the blister and the cover can bear against the upper face of the blister, or be a little separate from the upper face, to keep a game between the two.
  • Such a support is advantageously specifically adapted to a particular type of blister, in particular to optimize the maintenance and to limit the risk of errors.
  • the lid plays a role of maintaining the blister so that it does not deform, or at least to limit its deformations, so as to optimize the extraction maneuvers of the products.
  • It can also play a keying function, in the case where its openings are adapted, shaped and in position, so that it can be associated with only one type of blister.
  • Such a support also makes it possible to position the blister in a housing of standard dimensions so that it can be supported easily for the extraction of the products, and to be able to be inserted at any place in the cabinet storage.
  • the means of identification provided on each support allow optimized management of stocks and extraction of products.
  • these media identification means may consist of a read-only chip (or a barcode label read by a barcode reader or a camera).
  • they may contain the identification of the product, the extraction method (depending on each product referenced, the extraction specifications are coded), or the spatial distribution of the positioning of the products on the product. blister.
  • These media identification means may also consist of a read / write chip.
  • This chip can then contain other information and allow advanced treatments such as product traceability (batch number, expiry date), inventory management (updated with each extraction of the number of products remaining in the blister), update of programs Extraction in case of evolution, history of uses, version numbers, etc.
  • the stock of products is kept in time, even if the blister support is extracted from the storage cabinet and that there are several supports for the same type of storage. product started at the same time.
  • the information is stored on the blister media and not in an ancillary database, which makes it possible to obtain an independent blister / support set.
  • This set may possibly be recognized by any automated device of the same type that will only identify the product and follow the instructions of the chip embedded on the support.
  • the device according to the invention advantageously comprises a plurality of different supports, whose base and lid openings are adapted, in number, location and shape, to the different types of blisters that can be used, each support being adapted specifically to a particular blister and can accommodate one or more blisters.
  • each support is equipped with a lid provided with openings whose shape and dimensions correspond to those of the compartments of the blister intended to be associated with it, in order to optimize the positioning of said blister on its support and to provide a polarizing function.
  • the identification means formed on each blister medium consist of a remote read / write system, of the RFID chip type, for example, able to communicate with suitable detection means, of the RFID reader type. for example ; these identification means comprise a memory containing information on the type of packaged product, and / or on the location of these products on the surface of the blister, and / or on the stock of the products remaining on the blister, and / or on the location of the products remaining on the blister, and / or the method of extracting the products.
  • said extraction means comprise an extraction finger adapted to press the compartment of the blister positioned opposite, in order to expel or eject the product which is packaged in said compartment.
  • This extraction finger advantageously consists of a linear actuator movable in translation to ensure the expulsion of the packaged product; it is advantageously controlled in its race by positioning parameters and / or measurement of effort, to ensure the expulsion of the product, and possibly to verify this expulsion.
  • the extraction unit is movably arranged to allow the extraction means to be correctly positioned with respect to all the blister compartments associated with the various supports of the storage cabinet, so as to allow the extraction products packaged in the various stored blisters; in addition, said detection means associated with the identification means are then mounted on this mobile unit.
  • the blister supports are advantageously removably mounted in housings housed in the storage cabinet.
  • the storage cabinet advantageously comprises a plurality of juxtaposed columns of several superimposed docking receptacles for the blister carriers (s); these reception housing are each in the form of a drawer extractable along a horizontal axis, and the extraction unit is mounted horizontally and vertically movable (in xy) via one or more carriages, in front of said storage cabinet; on the other hand, this extraction unit comprises means allowing the unitary management of the drawers, to ensure their output and their entry along said horizontal axis, so, once said drawer in at least partially output position, to allow the implementation of the extraction means of the packaged products.
  • the extraction unit is mounted movably by means of a pair of carriages, one sliding horizontally and the other sliding vertically, to ensure its positioning opposite one of said drawers of the storage cabinet; the extraction means are themselves mounted mobile on said extraction unit, by means of a carriage movable perpendicularly to the axis of extraction of the drawers, so as to allow their positioning opposite the different compartments of a same cross-section of compartments of the blister carried by the support opposite.
  • the extraction unit advantageously comprises a motorized carriage, movable parallel to the extraction axis of the drawers, provided with means allowing the loading and release of the drawer disposed opposite, to ensure its output and re-entry.
  • the storage cabinet comprises a plurality of receiving housings arranged in the same horizontal plane for the blister supports, said extraction unit being mounted horizontally and in the same horizontal plane.
  • the extraction unit comprises said means for receiving the product extracted from its housing, which reception means are disposed under said extraction means, for receiving products by gravity.
  • reception means advantageously comprise a carousel rotatably mounted about a vertical axis, comprising a plurality of containers distributed over a circle centered on said axis of rotation, which containers comprise a removable closure means of their bottom, to allow - the receiving one or more products when said removable closure means is activated, and - the release by gravity of said one or more products, when deactivated.
  • the device 1 illustrated on the figure 1 consists of an automaton allowing the automated preparation of batches of drugs (or similar) from drugs packaged in blisters.
  • This device 1 mainly comprises a storage cabinet 2 associated with an extraction unit 3, as well as electronic / computer means 4 (PLC, control PC or similar) ensuring the operation of the extraction unit 3 to prepare the batches of wanted drugs.
  • PLC electronic / computer means 4
  • the storage cabinet 2 consists of a frame incorporating a plurality of housing in the form of extractable drawers 5.
  • each vertical column comprises a plurality of superimposed drawers 5.
  • the front of the cabinet 2 extends in a vertical plane; the drawers 5 each extend in a horizontal plane and they are each mounted on a slide structure which makes them extractable along a horizontal axis, perpendicular to the above-mentioned façade plane.
  • each drawer 5 is here composed of a horizontal plate 6 provided with a central opening 7, and its front face comprises a vertical return 8.
  • This vertical return 8 comprises two lateral orifices 9 and a central orifice 10; on the other hand, just behind the return 8, the plate 6 has two lateral openings 11.
  • drawers 5 are adapted to receive supports 12 of blisters B , as shown in the drawings. Figures 2 and 3 .
  • a blister B is schematically illustrated on the figure 3 .
  • a tablet comprising a plate P and a plurality of compartments C in each of which a tablet A of drug or the like is packaged.
  • the compartments C are arranged protruding from one side or both sides of the plate P , depending on the type of blister B.
  • the support 12 is in the form of two parts 13 and 14 intended to sandwich the blister B (and more particularly the plate P).
  • the first piece 13 consists of a plate-shaped base provided with a plurality of openings 15; its lower face is intended to rest on the tray 6 of the drawer 5 and its upper face is intended to receive one of the faces of the blister B (in particular, the bottom face of the blister).
  • the second piece 14 consists of a tray-like lid provided with a plurality of openings 16; its lower face is intended to bear on the other side of the blister B (the top face of the blister).
  • the openings 15 of the base 13 and the openings 16 of the cover 14 are adapted to be positioned facing the packing compartments of the blister B C.
  • openings 15 and 16 are adapted in number, positioning and shape, depending on the type of blister B to receive. They may be of the type an opening for a tablet, or an opening for several tablets, in particular depending on the rigidity of the blister, the distribution of the tablets and the difficulty of extraction.
  • the installation comprises a plurality of different supports 12, each adapted to specifically receive a particular blister B (and therefore a particular drug, a particular drug form or a particular drug dosage), and different types of supports 12 are available, to match the different types of blisters B (and therefore the different types of drugs) that can be used.
  • the base 13 of the support 12 allows the reception of the blister B and its cover 14 ensures its maintenance for the extraction operation of the packaged drugs, as explained below.
  • a small game can be provided between the blister B and the lid 14.
  • Each drawer 5 can receive all the different supports 12.
  • these drawers 5 comprise means (not shown) ensuring precise positioning of the removable supports 5.
  • each support 12 comprises identification means 18 which are specific to it, here centered on its front edge.
  • identification means 18 may consist of a number or a barcode, readable by appropriate detection means, preferably carried by the extraction unit 3.
  • these identification means 18 consist of a remote reading / writing system, RFID chip type or the like, able to communicate with RFID reader type detection means, advantageously carried by the extraction unit 3.
  • RFID reader type detection means advantageously carried by the extraction unit 3.
  • the identification means 18 may also consist of an embedded intelligence of the microprocessor type.
  • the identification means 18 may contain fixed information such as the type of medicament, the physical characteristics of the blister pack B (number of compartments C , form of the tablets A , coordinates xy of the tablets A on the blister pack B , the extraction program of the compressed) ; they may also contain variable information written and read by the associated detection means, for example at each batch preparation cycle, or at each feed of the carrier (eg tablet expiration date, batch number, date of machine setting, date of last dispensing, number of tablets still to be taken, etc.).
  • the detection means associated with the identification means 18 are connected to the electronic / computer means 4 (for example a control PC) to ensure a management of the stock of drugs contained in the cabinet 2, and also to manage the unit of extraction 3 so as to ensure the realization of the desired lots of drugs, as illustrated below.
  • the electronic / computer means 4 for example a control PC
  • the extraction unit 3 comprises extraction means for extracting the products from their compartments C A blister pack B; and the device 1 further comprises means for correctly positioning these extraction means facing the blister compartment C containing the product A to be extracted, these positioning means and extraction means being managed by the control PC 4.
  • the corresponding extraction means here consist of a linear actuator 20, visible in particular on the Figures 2 and 3 , adapted to press the compartment C of the blister B positioned opposite, so as to expel the conditioned tablet A , as illustrated on the Figures 4 to 6 .
  • a tablet passes through the opening 7 of the drawer 5 and it is recovered by gravity into a suitable container (e.g., carried by the extraction unit 3).
  • the extraction program of each type of tablet is integrated in the aforementioned identification means 18, or in the memory of the control PC 4; the implementation of this program is managed by the control PC 4.
  • control PC manages the stroke and / or the force applied on the extraction finger during the crushing phase of the compartments of the blister to ensure that the ejection of the tablet is optimal
  • the extraction means 20 may be associated with a detection means which informs that the tablet has been ejected, and which informs the control PC.
  • the finger 21 is advantageously associated with means which make it possible to ensure that the tablet A has been expelled, and / or which make it possible to verify this expulsion.
  • this finger 21 can be controlled in its race by positioning parameters and / or measurement of effort.
  • the extraction unit 3 is movably arranged to allow the extraction means 20 to be correctly positioned with respect to all the compartments C of blisters associated with the different supports 12 of the storage cabinet 2, in order to allow the extraction of all the tablets packaged in the various blisters B stored.
  • the extraction unit 3 which carries the linear actuator 20 comprises a frame 22 in the form of a main carriage, mounted vertically movable along a slide structure 23 forming a secondary carriage; this secondary carriage 23 is itself mounted to move horizontally along a fixed slide structure 24.
  • the displacement in xy of the main carriage 22 is achieved by means of adapted motorizations (not shown), for example of the electric stepper motor type, or brushless motors with positioning control, associated with toothed drive belts, the operation of which is managed by the pilot PC 4.
  • adapted motorizations for example of the electric stepper motor type, or brushless motors with positioning control, associated with toothed drive belts, the operation of which is managed by the pilot PC 4.
  • this main carriage 22 comprises means for ensuring the unitary management of the drawer 5 arranged facing, to allow its output and re-entry along its horizontal axis of mobility.
  • the motorized carriage 26 consist of a motorized carriage 26 guided on slides 27 and movable along an axis parallel to the extraction axis of the drawers 5.
  • This carriage 26 comprises a hook 28 which is articulated at 29 around a horizontal axis, and which is associated with tilt control means (not shown), for example of the actuator or electromagnet type associated with a return spring.
  • the motor means of the carriage 26 may consist of a stepping electric motor or a brushless motor with positioning control, associated with a toothed drive belt.
  • the hook 28 is actuated so as to cooperate with one of the orifices 11 of the drawer 5 to ensure its handling, with a view to its exit, and then of his return.
  • the tilting control means of the hook 28 and the motorization of the carriage 26 are managed by the control PC 4.
  • the linear actuator 20 is itself mounted to move on the main carriage 22 via a carriage 32 sliding on a slide structure 32 ', in association with a motor (for example of the electric motor type step-by-step or brushless motor with positioning control, associated with a toothed drive belt), that horizontally and perpendicularly to the extraction axis of the drawers 5.
  • a motor for example of the electric motor type step-by-step or brushless motor with positioning control, associated with a toothed drive belt
  • This displacement of the actuator 20 is made just above the mobility plane of the drawer 5, and it is managed by the control PC 4.
  • the corresponding xy coordinates of the conditioning compartments C on the blisters B are integrated in the RFID memory 18 of each support 12, or in the memory of the control PC 4.
  • the detection means 33 ( figure 9 ), of the RFID reader type, for example, are mounted on the main carriage 22 so as to allow communication with only one of the supports 12 (via its RFID chip 18), depending on the positioning of said carriage 22.
  • these detection means 33 are positioned at the front of the carriage 26, able to be placed just in front of the vertical return 8 of the drawer 5 arranged opposite, so as to be located near the detection means 18 of the corresponding support 12.
  • the central orifice 10 of the front 8 of the drawers 5 is placed between the chip 18 and the detection means 33; it facilitates communication between the two (by limiting the presence of walls).
  • These two pins 34 are intended to come into the orifices 9 of the drawer 5 disposed opposite, at the time of its handling for its maneuver, so as to ensure its support and positioning in height.
  • the extraction unit 3 (and more particularly the carriage 22) comprises means 35, arranged under the actuator 20, for gravity receiving tablets A extracted from their packaging compartments C.
  • these receiving means 35 comprise a motorized carousel 36, rotatably mounted around a vertical axis 36 'and comprising a plurality of containers 37.
  • the various containers 37 are distributed over a circle of the carousel 36, centered on the axis of rotation 36 '.
  • the same container 37 can be used to receive the various tablets constituting the batch of drugs of a patient, for each of its daily prescriptions.
  • the containers 37 are advantageously associated with a removable closure means of their bottom, thus allowing gravity release of the tablet or tablets of a container 37 considered, when said shutter means is deactivated.
  • the corresponding removable closure means may consist of a motorized rotary plate 38, disposed under the carousel 36 and constituting the bottom of the containers 37, this motorized plate 38 being equipped with a single orifice 39, whose positioning is managed by the control PC 4, to ensure the emptying of the desired container.
  • the reception means 35 may be associated with means for packaging each batch of drugs obtained, for example in sachets, in association with an identifying marking.
  • the control PC 4 manages the operation of the different engines associated with the extraction unit 3, the actuator 20 and the reception means 35, to ensure the preparation of predetermined batches of drugs, in a fast and reliable manner, from a pre-established programming, and also from the information communicated by the detection means 33.
  • control PC 4 Due to the different information received, and the associated programming, the control PC 4 also allows a very fine management of the stock of drugs in the cabinet 2.
  • the different drawers 5 of the storage cabinet 2 may each be associated with a visual cue indicating their empty state (for example an LED light cue).
  • This type of device allows appreciable time savings, a very fine stock management, a great traceability of the distribution of medicines and a reinforced security.
  • It can be used in retirement homes, hospitals, clinics or pharmacies. It can also be used in the homes of natural persons, for example in an elderly person.
  • a storage cabinet of cylindrical general shape, with vertical juxtaposed drawers (associated with a horizontally movable linear actuator).

Abstract

The device has a storage cabinet including supports (12) for reception of blister (B) of drug products (A). Positioning units e.g. carriage, position automatically an extraction unit (20) with respect to a compartment (C) of the blister. Identification units (18) e.g. radio frequency identification unit chip, associated with the supports cooperate with detection units. Electronic/computing units manage positioning and implementation of the extraction unit according to information of the detection units. Reception units e.g. studs, receive the product extracted from the compartment. The electronic/computing units are selected from a personal computer or a programmable logic controller.

Description

La présente invention concerne un dispositif automatisé de préparation de lots de produits, à partir de tels produits conditionnés en blisters, en particulier pour la préparation de lots individuels de médicaments (ou similaires) pour un patient.The present invention relates to an automated device for preparing batches of products, from such products packaged in blisters, in particular for the preparation of individual batches of drugs (or the like) for a patient.

Dans les hôpitaux, cliniques ou maisons de retraite notamment, la préparation des lots individuels de médicaments, à partir des prescriptions médicales de chaque patient, est généralement réalisée au moyen de médicaments en forme de comprimés ou de gélules conditionnées en blisters. Ces blisters constituent le conditionnement privilégié des laboratoires pharmaceutiques pour les produits qu'ils commercialisent. Ils consistent en une plaquette, souvent de forme générale rectangulaire, comportant une pluralité de compartiments qui reçoivent chacun un comprimé ou une gélule.In hospitals, clinics or nursing homes in particular, the preparation of individual batches of drugs, based on the medical prescriptions of each patient, is generally carried out by means of medicaments in the form of tablets or capsules packaged in blisters. These blisters are the preferred packaging of pharmaceutical companies for the products they market. They consist of a wafer, often of generally rectangular shape, comprising a plurality of compartments which each receive a tablet or capsule.

Le nombre, la forme et la répartition des compartiments de conditionnement sont propres à chaque médicament et il existe donc une très grande variété de blisters de conditionnement.The number, shape and distribution of the packaging compartments are specific to each drug and therefore there is a very wide variety of packaging blisters.

La personne chargée de la préparation de tels lots de médicaments doit extraire le comprimé recherché par dégradation de son compartiment, et elle doit répartir les différents médicaments extraits dans des contenants individuels du genre pilulier(s) notamment.The person responsible for the preparation of such batches of drugs must extract the desired tablet by degradation of its compartment, and it must distribute the various drugs extracted in individual containers of the kind pill (s) in particular.

Ces opérations sont cependant très généralement longues et fastidieuses, avec les risques d'erreurs inhérents.These operations are however generally very long and tedious, with the risks of inherent errors.

On connaît déjà des automates permettant la délivrance de lots individuels de médicaments, à partir de cassettes alimentées en vrac.Automata are already known for the delivery of individual batches of drugs, from cassettes fed in bulk.

Mais ces installations ne peuvent pas fonctionner avec des produits conditionnés sous forme de blisters.But these facilities can not work with products packaged as blisters.

Il existe encore des machines dites de « déblistérisation » qui assurent l'extraction des médicaments conditionnés en blisters, pour obtenir des lots mono-produit. Mais ces dispositifs ne règlent pas le problème de la préparation ultérieure des lots individualisés multi-médicaments, pour chaque patient.There are still machines called "deblistering" which ensure the extraction of drugs packaged in blisters, to obtain mono-product batches. But these devices do not solve the problem of the subsequent preparation of multi-drug individual lots for each patient.

Le document WO-98/29084 décrit aussi un dispositif automatisé pour la préparation de lots de produits tels que des médicaments, à partir de produits conditionnés en blisters.The document WO-98/29084 also describes an automated device for the preparation of batches of products such as drugs, from products packaged in blisters.

Dans ce dispositif, les blisters sont empilés les uns sur les autres dans des boîtes de réception équipées chacune d'un système d'identification.In this device, the blisters are stacked on each other in inboxes each equipped with an identification system.

Au niveau de chaque boîte, une unité de déplacement permet la prise en charge du blister le plus bas de la pile, pour l'extraire de cette pile et le positionner correctement en vue de permettre l'extraction de l'un des produits de son compartiment de conditionnement, par l'intermédiaire d'une unité d'extraction mobile.At each box, a unit of movement allows the management of the lowest blister of the stack, to extract it from this stack and position it correctly to allow the extraction of one of the products of its packaging compartment, via a mobile extraction unit.

Un conteneur placé sous cette unité d'extraction mobile assure la réception du produit extrait de son compartiment.A container placed under this mobile extraction unit ensures the receipt of the product extracted from its compartment.

Mais dans ce dispositif, la succession de déplacements des blisters (entrée et sortie des boîtes de stockage) en association avec l'extraction progressive des différents produits conditionnés dans chacun d'eux, ne peut que poser d'importants problèmes de tenue et de maintien de ces blisters, en particulier du fait de leurs déformations potentielles.But in this device, the succession of displacements of the blisters (entry and exit of the storage boxes) in association with the progressive extraction of the different products packaged in each one of them, can only pose important problems of holding and maintenance of these blisters, in particular because of their potential deformations.

D'autre part, l'identification générale d'une colonne de blisters empilés ne permet pas une gestion complète, détaillée et sure du stock de produits à disposition.On the other hand, the general identification of a column of stacked blisters does not allow a complete, detailed and reliable management of the stock of products available.

La présente invention a pour but de remédier à ces inconvénients en proposant un système automatisé de préparation de lots individuels de médicaments (ou similaires) à partir de médicaments conditionnés en blisters, chacun de ces blisters étant associé à un support particulier, constitué d'une association embase/couvercle et comportant ses propres moyens d'identification.The present invention aims to overcome these disadvantages by providing an automated system for preparing individual batches of drugs (or the like) from drugs packaged in blisters, each of these blisters being associated with a particular carrier, consisting of a association base / lid and having its own means of identification.

Pour cela, le dispositif correspondant, conforme à l'invention, comporte :

  • une armoire de stockage comprenant une pluralité de supports, chacun adapté pour la réception d'au moins un blister de produit(s),
  • une unité d'extraction munie de moyens d'extraction pour extraire d'un blister réceptionné par l'un desdits supports, l'un desdits produits de son compartiment de conditionnement,
  • des moyens de positionnement, adaptés pour positionner automatiquement lesdits moyens d'extraction en regard du compartiment du blister contenant le produit à extraire,
  • des moyens électroniques/informatiques pour gérer le positionnement et la mise en oeuvre desdits moyens d'extraction, et
  • des moyens pour la réception dudit produit extrait de son compartiment ; et ce dispositif est caractérisé par le fait que chaque blister stocké dans l'armoire de stockage est associé à son propre support constitué :
  • d'une embase munie d'une pluralité d'ouvertures, pour recevoir l'une des faces dudit blister associé, et
  • d'un couvercle également muni d'une pluralité d'ouvertures,
For this, the corresponding device according to the invention comprises:
  • a storage cabinet comprising a plurality of supports, each adapted for receiving at least one product blister (s),
  • an extraction unit provided with extraction means for extracting from a blister received by one of said supports, one of said products from its conditioning compartment,
  • positioning means, adapted to automatically position said extraction means facing the compartment of the blister containing the product to be extracted,
  • electronic / computer means for managing the positioning and implementation of said extraction means, and
  • means for receiving said product extracted from its compartment; and this device is characterized in that each blister stored in the storage cabinet is associated with its own support consisting of:
  • a base provided with a plurality of openings, for receiving one of the faces of said associated blister, and
  • a lid also provided with a plurality of openings,

ladite embase et ledit couvercle étant aptes à prendre ledit blister en sandwich, avec leurs ouvertures en correspondance et placées en regard d'un ou de plusieurs desdits compartiments dudit blister, en vue d'assurer le maintien de ce dernier et éviter ses déformations au cours des phases d'extraction des produits.said base and said cover being adapted to take said sandwich blister, with their openings in correspondence and placed opposite one or more of said compartments of said blister, to ensure the maintenance of the latter and prevent its deformations during product extraction phases.

En outre, chaque support comporte des moyens d'identification aptes à coopérer avec des moyens de détection, en particulier pour la gestion du positionnement et de la mise en oeuvre desdits moyens d'extraction par lesdits moyens électroniques/informatiques.In addition, each support comprises identification means capable of cooperating with detection means, in particular for the management of the positioning and implementation of said extraction means by said electronic / computer means.

La prise en sandwich de chaque blister entre son embase et son couvercle de réception assure son maintien correct en vue de ses déplacements et des opérations d'extraction de produits. L'embase supporte la face inférieure du blister et le couvercle peut venir en appui contre la face supérieure de ce blister, ou bien être un peu séparé de cette face supérieure, pour conserver un jeu entre les deux.The sandwiching of each blister between its base and its receiving cover ensures its proper maintenance for its movements and product extraction operations. The base supports the underside of the blister and the cover can bear against the upper face of the blister, or be a little separate from the upper face, to keep a game between the two.

Un tel support est avantageusement spécifiquement adapté à un type de blister particulier, notamment pour optimiser le maintien et pour limiter les risques d'erreurs.Such a support is advantageously specifically adapted to a particular type of blister, in particular to optimize the maintenance and to limit the risk of errors.

Le couvercle joue un rôle de maintien du blister afin qu'il ne se déforme pas, ou tout au moins pour limiter ses déformations, de manière à optimiser les manoeuvres d'extraction des produits.The lid plays a role of maintaining the blister so that it does not deform, or at least to limit its deformations, so as to optimize the extraction maneuvers of the products.

Il joue également le rôle de positionner correctement le blister en face des ouvertures de l'embase.It also plays the role of correctly positioning the blister in front of the openings of the base.

Il peut également jouer une fonction de détrompeur, dans le cas où ses ouvertures sont adaptées, en forme et en position, pour qu'on ne puisse l'associer qu'avec un seul type de blister.It can also play a keying function, in the case where its openings are adapted, shaped and in position, so that it can be associated with only one type of blister.

Un tel support permet aussi de positionner le blister dans un logement d'accueil de dimensions normalisées pour qu'il puisse être pris en charge facilement pour l'extraction des produits, et pour pouvoir être inséré à n'importe quel endroit dans l'armoire de stockage.Such a support also makes it possible to position the blister in a housing of standard dimensions so that it can be supported easily for the extraction of the products, and to be able to be inserted at any place in the cabinet storage.

D'autre part, les moyens d'identification prévus sur chaque support permettent une gestion optimisée des stocks et de l'extraction des produits.On the other hand, the means of identification provided on each support allow optimized management of stocks and extraction of products.

Par exemple, ces moyens d'identification des supports peuvent consister en une puce électronique en lecture seule (ou en une étiquette-code barre lue par un lecteur de code barre ou une caméra). Dans ce cas, ils peuvent contenir l'identification du produit, la méthode d'extraction (en fonction de chaque produit référencé, on y code les spécifications d'extraction), ou encore la répartition dans l'espace du positionnement des produits sur le blister.For example, these media identification means may consist of a read-only chip (or a barcode label read by a barcode reader or a camera). In this case, they may contain the identification of the product, the extraction method (depending on each product referenced, the extraction specifications are coded), or the spatial distribution of the positioning of the products on the product. blister.

Ces moyens d'identification des supports peuvent aussi consister en une puce en lecture/écriture. Cette puce pourra alors contenir d'autres informations et permettre des traitements avancés comme la traçabilité des produits (numéro de lot, date de péremption), la gestion des stocks (mise à jour à chaque extraction du nombre de produits restant dans le blister), mise à jour des programmes d'extraction en cas d'évolution, historique des utilisations, numéros de versions, etc.These media identification means may also consist of a read / write chip. This chip can then contain other information and allow advanced treatments such as product traceability (batch number, expiry date), inventory management (updated with each extraction of the number of products remaining in the blister), update of programs Extraction in case of evolution, history of uses, version numbers, etc.

Dans ce dernier cas d'une mémoire en lecture/écriture, le stock de produits est conservé dans le temps, même si le support de blister est extrait de l'armoire de stockage et que l'on possède plusieurs supports pour un même type de produit entamés en même temps.In the latter case of a read / write memory, the stock of products is kept in time, even if the blister support is extracted from the storage cabinet and that there are several supports for the same type of storage. product started at the same time.

Les informations étant stockées sur le support de blister et non dans une base de données annexe, cela permet d'obtenir un ensemble blister/support autonome. Cet ensemble pourra éventuellement être reconnu par tout dispositif automatisé du même type qui n'aura qu'à identifier le produit et suivre les instructions de la puce embarquée sur le support.The information is stored on the blister media and not in an ancillary database, which makes it possible to obtain an independent blister / support set. This set may possibly be recognized by any automated device of the same type that will only identify the product and follow the instructions of the chip embedded on the support.

D'autre part, le dispositif conforme à l'invention comporte avantageusement une pluralité de supports différents, dont les ouvertures d'embase et de couvercle sont adaptées, en nombre, emplacement et forme, aux différents types de blisters susceptibles d'être utilisés, chaque support étant adapté spécifiquement à un blister particulier et pouvant accueillir un ou plusieurs blisters.On the other hand, the device according to the invention advantageously comprises a plurality of different supports, whose base and lid openings are adapted, in number, location and shape, to the different types of blisters that can be used, each support being adapted specifically to a particular blister and can accommodate one or more blisters.

De préférence, chaque support est équipé d'un couvercle muni d'ouvertures dont la forme et les dimensions correspondent à celles des compartiments du blister destiné à lui être associé, pour optimiser le positionnement dudit blister sur son support et assurer une fonction détrompeur.Preferably, each support is equipped with a lid provided with openings whose shape and dimensions correspond to those of the compartments of the blister intended to be associated with it, in order to optimize the positioning of said blister on its support and to provide a polarizing function.

Encore selon une autre caractéristique préférentielle, les moyens d'identification ménagés sur chaque support de blister consistent en un système de lecture/écriture à distance, de type puce RFID par exemple, apte à communiquer avec des moyens de détection adaptés, du type lecteur RFID par exemple ; ces moyens d'identification comportent une mémoire contenant des informations sur le type de produit conditionné, et/ou sur la localisation de ces produits sur la surface du blister, et/ou sur le stock des produits restant sur le blister, et/ou sur l'emplacement des produits restant sur le blister, et/ou sur la méthode d'extraction des produits.According to another preferred feature, the identification means formed on each blister medium consist of a remote read / write system, of the RFID chip type, for example, able to communicate with suitable detection means, of the RFID reader type. for example ; these identification means comprise a memory containing information on the type of packaged product, and / or on the location of these products on the surface of the blister, and / or on the stock of the products remaining on the blister, and / or on the location of the products remaining on the blister, and / or the method of extracting the products.

Toujours selon une forme de réalisation préférée, lesdits moyens d'extraction comprennent un doigt d'extraction adapté pour faire pression sur le compartiment du blister positionné en regard, afin d'expulser ou éjecter le produit qui est conditionné dans ledit compartiment.Still according to a preferred embodiment, said extraction means comprise an extraction finger adapted to press the compartment of the blister positioned opposite, in order to expel or eject the product which is packaged in said compartment.

Ce doigt d'extraction consiste avantageusement en un actionneur linéaire mobile en translation pour assurer l'expulsion du produit conditionné ; il est avantageusement contrôlé dans sa course par des paramètres de positionnement et/ou de mesure d'effort, pour s'assurer de l'expulsion du produit, et éventuellement pour vérifier cette expulsion.This extraction finger advantageously consists of a linear actuator movable in translation to ensure the expulsion of the packaged product; it is advantageously controlled in its race by positioning parameters and / or measurement of effort, to ensure the expulsion of the product, and possibly to verify this expulsion.

De préférence, l'unité d'extraction est prévue mobile pour permettre le positionnement correct des moyens d'extraction par rapport à l'ensemble des compartiments de blisters associés aux différents supports de l'armoire de stockage, de manière à permettre l'extraction des produits conditionnés dans les différents blisters stockés ; en outre, lesdits moyens de détection associés aux moyens d'identification sont alors montés sur cette unité mobile.Preferably, the extraction unit is movably arranged to allow the extraction means to be correctly positioned with respect to all the blister compartments associated with the various supports of the storage cabinet, so as to allow the extraction products packaged in the various stored blisters; in addition, said detection means associated with the identification means are then mounted on this mobile unit.

D'autre part, les supports de blisters sont avantageusement montés amovibles dans des logements d'accueil ménagés dans l'armoire de stockage.On the other hand, the blister supports are advantageously removably mounted in housings housed in the storage cabinet.

Selon une autre particularité, l'armoire de stockage comporte avantageusement une pluralité de colonnes juxtaposées de plusieurs logements d'accueil superposés pour les supports de blister(s) ; ces logements d'accueil se présentent chacun sous la forme d'un tiroir extractible selon un axe horizontal, et l'unité d'extraction est montée mobile horizontalement et verticalement (en x-y) par l'intermédiaire d'un ou de plusieurs chariots, devant ladite armoire de stockage ; d'autre part, cette unité d'extraction comprend des moyens permettant la prise en charge unitaire des tiroirs, pour assurer leur sortie et leur entrée selon ledit axe horizontal, de manière, une fois ledit tiroir en position au moins partiellement sortie, à permettre la mise en oeuvre des moyens d'extraction des produits conditionnés.According to another feature, the storage cabinet advantageously comprises a plurality of juxtaposed columns of several superimposed docking receptacles for the blister carriers (s); these reception housing are each in the form of a drawer extractable along a horizontal axis, and the extraction unit is mounted horizontally and vertically movable (in xy) via one or more carriages, in front of said storage cabinet; on the other hand, this extraction unit comprises means allowing the unitary management of the drawers, to ensure their output and their entry along said horizontal axis, so, once said drawer in at least partially output position, to allow the implementation of the extraction means of the packaged products.

Selon une autre caractéristique, l'unité d'extraction est montée mobile par l'intermédiaire d'un couple de chariots, l'un coulissant horizontalement et l'autre coulissant verticalement, pour assurer son positionnement en regard de l'un desdits tiroirs de l'armoire de stockage ; les moyens d'extraction sont eux-mêmes montés mobiles sur ladite unité d'extraction, au moyen d'un chariot déplaçable perpendiculairement à l'axe d'extraction des tiroirs, de manière à permettre leur positionnement en regard des différents compartiments d'une même ligne transversale de compartiments du blister porté par le support en regard.According to another characteristic, the extraction unit is mounted movably by means of a pair of carriages, one sliding horizontally and the other sliding vertically, to ensure its positioning opposite one of said drawers of the storage cabinet; the extraction means are themselves mounted mobile on said extraction unit, by means of a carriage movable perpendicularly to the axis of extraction of the drawers, so as to allow their positioning opposite the different compartments of a same cross-section of compartments of the blister carried by the support opposite.

L'unité d'extraction comporte avantageusement un chariot motorisé, mobile parallèlement à l'axe d'extraction des tiroirs, muni de moyens permettant la prise en charge et la libération du tiroir disposé en regard, pour assurer sa sortie et sa rentrée.The extraction unit advantageously comprises a motorized carriage, movable parallel to the extraction axis of the drawers, provided with means allowing the loading and release of the drawer disposed opposite, to ensure its output and re-entry.

Selon une variante de réalisation, l'armoire de stockage comporte une pluralité de logements d'accueil disposés dans le même plan horizontal pour les supports de blisters, ladite unité d'extraction étant montée mobile horizontalement et dans le même plan horizontal.According to an alternative embodiment, the storage cabinet comprises a plurality of receiving housings arranged in the same horizontal plane for the blister supports, said extraction unit being mounted horizontally and in the same horizontal plane.

Selon une autre particularité, l'unité d'extraction comporte lesdits moyens de réception du produit extrait de son logement, lesquels moyens de réception sont disposés sous lesdits moyens d'extraction, pour la réception des produits par gravité.According to another feature, the extraction unit comprises said means for receiving the product extracted from its housing, which reception means are disposed under said extraction means, for receiving products by gravity.

Ces moyens de réception comprennent avantageusement un carrousel monté rotatif autour d'un axe vertical, comportant une pluralité de conteneurs répartis sur un cercle centré sur ledit axe de rotation, lesquels conteneurs comportent un moyen d'obturation amovible de leur fond, pour permettre - la réception d'un ou de plusieurs produits lorsque ledit moyen d'obturation amovible est activé, et - la libération par gravité dudit ou desdits produits, lorsqu'il est désactivé.These reception means advantageously comprise a carousel rotatably mounted about a vertical axis, comprising a plurality of containers distributed over a circle centered on said axis of rotation, which containers comprise a removable closure means of their bottom, to allow - the receiving one or more products when said removable closure means is activated, and - the release by gravity of said one or more products, when deactivated.

L'invention sera encore illustrée, sans être aucunement limitée, par la description suivante d'une forme de réalisation particulière, donnée uniquement à titre d'exemple et représentée sur les dessins annexés dans lesquels :

  • la figure 1 est une vue générale, de face, d'un dispositif automatisé de préparation de lots de produits, conforme à l'invention ;
  • la figure 2 est une vue en perspective, de l'un des supports de blisters du dispositif de la figure 1, positionné sur son tiroir support ;
  • la figure 3 montre le support de la figure 2, en perspective éclatée ;
  • les figures 4, 5 et 6 sont des vues schématiques, en coupe, illustrant trois étapes de l'extraction des produits en dehors de leur compartiment de conditionnement du blister ;
  • la figure 7 est une vue en perspective montrant l'unité d'extraction du dispositif, de manière agrandie (vue en perspective par-dessus) ;
  • la figure 8 est une vue en perspective agrandie illustrant le détail d'une partie de l'unité d'extraction du dispositif ;
  • la figure 9 est encore une vue en perspective agrandie montrant une partie de l'unité d'extraction (vue en perspective légèrement par-dessous) ;
  • la figure 10 montre, vue en perspective par-dessous, l'unité d'extraction avec le carrousel de réception des produits.
The invention will be further illustrated, without being limited in any way, by the following description of a particular embodiment, given solely by way of example and shown in the accompanying drawings in which:
  • the figure 1 is a general view, front view, of an automated device for preparing batches of products, according to the invention;
  • the figure 2 is a perspective view, of one of the blister media of the device of the figure 1 , positioned on its support drawer;
  • the figure 3 shows the support of the figure 2 in exploded perspective;
  • the Figures 4, 5 and 6 are schematic views, in section, illustrating three stages of the extraction of products outside their blister packaging compartment;
  • the figure 7 is a perspective view showing the extraction unit of the device, magnified (perspective view from above);
  • the figure 8 is an enlarged perspective view illustrating the detail of a portion of the extraction unit of the device;
  • the figure 9 is still an enlarged perspective view showing part of the extraction unit (perspective view slightly below);
  • the figure 10 shows, perspective view from below, the extraction unit with the carousel for receiving products.

Le dispositif 1 illustré sur la figure 1 consiste en un automate permettant la préparation automatisée de lots de médicaments (ou similaires) à partir de médicaments conditionnés en blisters.The device 1 illustrated on the figure 1 consists of an automaton allowing the automated preparation of batches of drugs (or similar) from drugs packaged in blisters.

Ce dispositif 1 comporte principalement une armoire de stockage 2 associée à une unité d'extraction 3, ainsi que des moyens électroniques/informatiques 4 (automate, PC contrôle ou similaire) assurant le fonctionnement de l'unité d'extraction 3 pour préparer les lots de médicaments recherchés.This device 1 mainly comprises a storage cabinet 2 associated with an extraction unit 3, as well as electronic / computer means 4 (PLC, control PC or similar) ensuring the operation of the extraction unit 3 to prepare the batches of wanted drugs.

L'armoire de stockage 2 consiste en un bâti intégrant une pluralité de logements en forme de tiroirs extractibles 5.The storage cabinet 2 consists of a frame incorporating a plurality of housing in the form of extractable drawers 5.

Elle comporte une pluralité de colonnes verticales juxtaposées de tiroirs 5 ; chaque colonne verticale comporte une pluralité de tiroirs 5 superposés.It comprises a plurality of vertical columns juxtaposed with drawers 5; each vertical column comprises a plurality of superimposed drawers 5.

La façade de l'armoire 2 s'étend dans un plan vertical ; les tiroirs 5 s'étendent quant à eux chacun dans un plan horizontal et ils sont montés chacun sur une structure de glissières qui les rendent extractibles selon un axe horizontal, perpendiculaire au plan de façade précité.The front of the cabinet 2 extends in a vertical plane; the drawers 5 each extend in a horizontal plane and they are each mounted on a slide structure which makes them extractable along a horizontal axis, perpendicular to the above-mentioned façade plane.

Comme on peut le voir sur les figures 2 et 3, chaque tiroir 5 est ici composé d'un plateau horizontal 6 muni d'une ouverture centrale 7, et sa face avant comporte un retour vertical 8.As can be seen on the Figures 2 and 3 each drawer 5 is here composed of a horizontal plate 6 provided with a central opening 7, and its front face comprises a vertical return 8.

Ce retour vertical 8 comporte deux orifices latéraux 9 et un orifice central 10 ; d'autre part, juste derrière le retour 8, le plateau 6 comporte deux ouvertures latérales 11.This vertical return 8 comprises two lateral orifices 9 and a central orifice 10; on the other hand, just behind the return 8, the plate 6 has two lateral openings 11.

Ces tiroirs 5 sont adaptés pour recevoir des supports 12 de blisters B, comme illustré sur les figures 2 et 3.These drawers 5 are adapted to receive supports 12 of blisters B , as shown in the drawings. Figures 2 and 3 .

Un blister B est illustré de manière schématique sur la figure 3.A blister B is schematically illustrated on the figure 3 .

Il s'agit d'un blister standard du commerce.This is a standard blister of commerce.

De manière classique, il consiste en une tablette comportant un plateau P et une pluralité de compartiments C dans chacun desquels est conditionné un comprimé A de médicament ou similaire. Les compartiments C sont ménagés en saillie, d'un côté ou des deux côtés du plateau P, selon le type de blister B.Typically, it consists of a tablet comprising a plate P and a plurality of compartments C in each of which a tablet A of drug or the like is packaged. The compartments C are arranged protruding from one side or both sides of the plate P , depending on the type of blister B.

Le support 12 se présente sous la forme de deux pièces 13 et 14 destinées à prendre en sandwich le blister B (et plus particulièrement son plateau P).The support 12 is in the form of two parts 13 and 14 intended to sandwich the blister B (and more particularly the plate P).

La première pièce 13 consiste en une embase en forme de plateau muni d'une pluralité d'ouvertures 15 ; sa face inférieure est destinée à venir reposer sur le plateau 6 du tiroir 5 et sa face supérieure est destinée à recevoir l'une des faces du blister B (en particulier, la face de dessous du blister).The first piece 13 consists of a plate-shaped base provided with a plurality of openings 15; its lower face is intended to rest on the tray 6 of the drawer 5 and its upper face is intended to receive one of the faces of the blister B (in particular, the bottom face of the blister).

La seconde pièce 14 consiste en un couvercle également en forme de plateau muni d'une pluralité d'ouvertures 16 ; sa face inférieure est destinée à venir prendre appui sur l'autre face du blister B (la face de dessus du blister).The second piece 14 consists of a tray-like lid provided with a plurality of openings 16; its lower face is intended to bear on the other side of the blister B (the top face of the blister).

Les ouvertures 15 de l'embase 13 et les ouvertures 16 du couvercle 14 sont adaptées pour venir en regard des compartiments de conditionnement C du blister B.The openings 15 of the base 13 and the openings 16 of the cover 14 are adapted to be positioned facing the packing compartments of the blister B C.

Ces ouvertures 15 et 16 sont adaptées, en nombre, en positionnement et en forme, selon le type de blister B à recevoir. Elles peuvent être du type une ouverture pour un comprimé, ou une ouverture pour plusieurs comprimés, en particulier en fonction de la rigidité du blister, de la répartition des comprimés et de la difficulté d'extraction.These openings 15 and 16 are adapted in number, positioning and shape, depending on the type of blister B to receive. They may be of the type an opening for a tablet, or an opening for several tablets, in particular depending on the rigidity of the blister, the distribution of the tablets and the difficulty of extraction.

L'installation comporte une pluralité de supports 12 différents, adaptés chacun pour recevoir spécifiquement un blister B particulier (et donc un médicament particulier, une forme de médicament particulière ou un dosage particulier de médicament), et différents types de supports 12 sont à disposition, pour correspondre aux différents types de blisters B (et donc aux différents types de médicaments) susceptibles d'être utilisés.The installation comprises a plurality of different supports 12, each adapted to specifically receive a particular blister B (and therefore a particular drug, a particular drug form or a particular drug dosage), and different types of supports 12 are available, to match the different types of blisters B (and therefore the different types of drugs) that can be used.

Chaque support 12 est conçu pour un type de blister et un type de médicament ; il y a appariement et correspondance unique entre un blister et son support, ceci étant dû à la forme des supports qui ne peuvent recevoir que des blisters aux formes correspondantes et à l'identification du produit (1 support = un produit) ; pour des raisons de reconnaissance on peut graver sur le support le type de médicament pour lequel il est réalisé.Each support 12 is designed for a type of blister and a type of medication; there is a pairing and unique correspondence between a blister and its support, this being due to the shape of the supports which can only receive blisters to the corresponding forms and to the identification of the product (1 support = a product); for reasons of recognition, the type of medicine for which it is made can be engraved on the support.

L'embase 13 du support 12 permet la réception du blister B et son couvercle 14 assure son maintien en vue de l'opération d'extraction des médicaments conditionnés, comme expliqué plus loin. Eventuellement, un petit jeu peut être prévu entre le blister B et le couvercle 14.The base 13 of the support 12 allows the reception of the blister B and its cover 14 ensures its maintenance for the extraction operation of the packaged drugs, as explained below. Optionally, a small game can be provided between the blister B and the lid 14.

Chaque tiroir 5 peut recevoir tous les supports 12 différents. De préférence, ces tiroirs 5 comportent des moyens (non représentés) assurant un positionnement précis des supports 5 amovibles.Each drawer 5 can receive all the different supports 12. Preferably, these drawers 5 comprise means (not shown) ensuring precise positioning of the removable supports 5.

D'autre part, chaque support 12 comporte des moyens d'identification 18 qui lui sont propres, ici centrés sur sa bordure avant.On the other hand, each support 12 comprises identification means 18 which are specific to it, here centered on its front edge.

Ces moyens d'identification 18 peuvent consister en un numéro ou en un code barres, lisible en lecture par des moyens de détection appropriés, de préférence portés par l'unité d'extraction 3.These identification means 18 may consist of a number or a barcode, readable by appropriate detection means, preferably carried by the extraction unit 3.

De préférence, ces moyens d'identification 18 consistent en un système de lecture/écriture à distance, type puce RFID ou similaire, apte à communiquer avec des moyens de détection du type lecteur RFID, avantageusement portés par l'unité d'extraction 3. On peut encore utiliser un système WIFI ou tout autre principe communicant. Les moyens d'identification 18 peuvent aussi consister en une intelligence embarquée du type microprocesseur.Preferably, these identification means 18 consist of a remote reading / writing system, RFID chip type or the like, able to communicate with RFID reader type detection means, advantageously carried by the extraction unit 3. One can still use a WIFI system or any other communicating principle. The identification means 18 may also consist of an embedded intelligence of the microprocessor type.

Les moyens d'identification 18 peuvent contenir des informations fixes telles que le type de médicament, les caractéristiques physiques du blister B (nombre de compartiments C, forme des comprimés A, coordonnées x-y des comprimés A sur le blister B, programme d'extraction du comprimé) ; ils peuvent aussi contenir des informations variables écrites et lues par les moyens de détection associés, par exemple à chaque cycle de préparation de lots, ou à chaque alimentation du support (par exemple date de péremption des comprimés, numéro de lot, date de mise en machine, date de dernière dispensation, nombre de comprimés restant à prendre, etc.).The identification means 18 may contain fixed information such as the type of medicament, the physical characteristics of the blister pack B (number of compartments C , form of the tablets A , coordinates xy of the tablets A on the blister pack B , the extraction program of the compressed) ; they may also contain variable information written and read by the associated detection means, for example at each batch preparation cycle, or at each feed of the carrier (eg tablet expiration date, batch number, date of machine setting, date of last dispensing, number of tablets still to be taken, etc.).

Les moyens de détection associés aux moyens d'identification 18 sont reliés aux moyens électroniques/informatiques 4 (par exemple un PC contrôle) pour assurer une gestion du stock de médicaments contenus dans l'armoire 2, et aussi pour gérer l'unité d'extraction 3 de manière à assurer la réalisation des lots recherchés de médicaments, de la manière illustrée ci-après.The detection means associated with the identification means 18 are connected to the electronic / computer means 4 (for example a control PC) to ensure a management of the stock of drugs contained in the cabinet 2, and also to manage the unit of extraction 3 so as to ensure the realization of the desired lots of drugs, as illustrated below.

En particulier, l'unité d'extraction 3 comporte des moyens d'extraction pour extraire les produits A de leurs compartiments C de blisters B ; et le dispositif 1 comporte encore des moyens pour positionner correctement ces moyens d'extraction en regard du compartiment C de blister contenant le produit A à extraire, ces moyens de positionnement et moyens d'extraction étant gérés par le PC contrôle 4.In particular, the extraction unit 3 comprises extraction means for extracting the products from their compartments C A blister pack B; and the device 1 further comprises means for correctly positioning these extraction means facing the blister compartment C containing the product A to be extracted, these positioning means and extraction means being managed by the control PC 4.

Les moyens d'extraction correspondants consistent ici en un actionneur linéaire 20, visible notamment sur les figures 2 et 3, adapté pour faire pression sur le compartiment C du blister B positionné en regard, de manière à expulser le comprimé A conditionné, de la manière illustrée sur les figures 4 à 6.The corresponding extraction means here consist of a linear actuator 20, visible in particular on the Figures 2 and 3 , adapted to press the compartment C of the blister B positioned opposite, so as to expel the conditioned tablet A , as illustrated on the Figures 4 to 6 .

Sur la figure 4, on remarque le tiroir horizontal 5 qui reçoit le support 12, avec le blister B pris en sandwich entre ses deux pièces constitutives 13 et 14. Au-dessus du support 12, on a représenté schématiquement l'actionneur linéaire 20 avec son doigt d'extraction 21 à mouvement de translation verticale, positionné juste au-dessus du compartiment C contenant le comprimé A à extraire.On the figure 4 , we notice the horizontal drawer 5 which receives the support 12, with the blister B sandwiched between its two component parts 13 and 14. Above the support 12, there is shown schematically the linear actuator 20 with its finger. extraction 21 vertical translation movement, positioned just above the compartment C containing the tablet A to extract.

Lorsque l'actionneur linéaire 20 reçoit la commande du PC contrôle 4, son doigt d'extraction 21 descend (figure 5), pénètre dans l'ouverture 16 en regard du couvercle 14, vient prendre appui sur le dessus du compartiment C et le déforme jusqu'à ce que le comprimé A dégrade la partie de dessous dudit compartiment C, et jusqu'à ce que ce comprimé A soit expulsé par l'ouverture 15 en regard de l'embase 13 (figure 6).When the linear actuator 20 receives the command from the control PC 4, its extraction finger 21 goes down ( figure 5 ), enters the opening 16 opposite the lid 14, is supported on the top of the compartment C and deforms it until the tablet A degrades the bottom part of said compartment C , and until this A tablet is expelled through the opening 15 opposite of the base 13 ( figure 6 ).

Le comprimé A passe au travers de l'ouverture 7 du tiroir 5 et il est récupéré par gravité dans un contenant adapté (par exemple porté par l'unité d'extraction 3). A tablet passes through the opening 7 of the drawer 5 and it is recovered by gravity into a suitable container (e.g., carried by the extraction unit 3).

Il peut être prévu un ou plusieurs mouvements de translation du doigt d'extraction 21 pour expulser le comprimé A, en fonction notamment de la forme et de la taille de ce comprimé. Le programme d'extraction de chaque type de comprimé est intégré dans les moyens d'identification 18 précités, ou dans la mémoire du PC contrôle 4 ; la mise en oeuvre de ce programme est gérée par le PC contrôle 4.It can be provided one or more translation movements of the extraction finger 21 to expel the tablet A , depending in particular on the shape and size of this tablet. The extraction program of each type of tablet is integrated in the aforementioned identification means 18, or in the memory of the control PC 4; the implementation of this program is managed by the control PC 4.

Il peut aussi être prévu que le PC contrôle gère la course et/ou l'effort appliqué sur le doigt d'extraction pendant la phase d'écrasement des compartiments du blister pour garantir que l'éjection du comprimé soit optimaleIt can also be expected that the control PC manages the stroke and / or the force applied on the extraction finger during the crushing phase of the compartments of the blister to ensure that the ejection of the tablet is optimal

Le doigt d'extraction 21 peut par exemple être affecté du cycle d'éjection spécialisé suivant :

  • on descend de 1,5 cm
  • puis on appuie selon une force de 2N
  • puis on remonte
  • puis on se déplace de 5 mm
  • puis on descend de 1,5 cm
  • puis on appuie selon une force de 2N
  • le comprimé sort.
The extraction finger 21 may for example be assigned the following specialized ejection cycle:
  • we go down 1.5 cm
  • then presses with a force of 2N
  • then we go back
  • then we move 5 mm
  • then we go down 1.5 cm
  • then presses with a force of 2N
  • the tablet comes out.

Les moyens d'extraction 20 peuvent être associés à un moyen de détection qui informe que le comprimé a bien été éjecté, et qui en informe le PC contrôle. Pour cela, le doigt 21 est avantageusement associé à des moyens qui permettent de s'assurer que le comprimé A a été expulsé, et/ou qui permettent de vérifier cette expulsion. Dans ce cadre, ce doigt 21 peut être contrôlé dans sa course par des paramètres de positionnement et/ou de mesure d'effort.The extraction means 20 may be associated with a detection means which informs that the tablet has been ejected, and which informs the control PC. For this, the finger 21 is advantageously associated with means which make it possible to ensure that the tablet A has been expelled, and / or which make it possible to verify this expulsion. In this context, this finger 21 can be controlled in its race by positioning parameters and / or measurement of effort.

L'unité d'extraction 3 est prévue mobile pour permettre le positionnement correct des moyens d'extraction 20 par rapport à l'ensemble des compartiments C de blisters associés aux différents supports 12 de l'armoire de stockage 2, en vue de permettre l'extraction de tous les comprimés conditionnés dans les différents blisters B stockés.The extraction unit 3 is movably arranged to allow the extraction means 20 to be correctly positioned with respect to all the compartments C of blisters associated with the different supports 12 of the storage cabinet 2, in order to allow the extraction of all the tablets packaged in the various blisters B stored.

Pour cela, comme on peut le voir sur la figure 1, l'unité d'extraction 3 qui porte l'actionneur linéaire 20 comprend un châssis 22 en forme de chariot principal, monté mobile verticalement le long d'une structure de glissières 23 formant chariot secondaire ; ce chariot secondaire 23 est lui-même monté mobile horizontalement le long d'une structure de glissières fixe 24.For this, as we can see on the figure 1 , the extraction unit 3 which carries the linear actuator 20 comprises a frame 22 in the form of a main carriage, mounted vertically movable along a slide structure 23 forming a secondary carriage; this secondary carriage 23 is itself mounted to move horizontally along a fixed slide structure 24.

Le déplacement en x-y du chariot principal 22 est réalisé au moyen de motorisations adaptées (non représentées), par exemple du type moteurs électriques pas à pas, ou moteurs brushless avec contrôle du positionnement, associés à des courroies crantées d'entraînement, dont le fonctionnement est géré par le PC pilote 4.The displacement in xy of the main carriage 22 is achieved by means of adapted motorizations (not shown), for example of the electric stepper motor type, or brushless motors with positioning control, associated with toothed drive belts, the operation of which is managed by the pilot PC 4.

D'autre part, ce chariot principal 22 comporte des moyens pour assurer la prise en charge unitaire du tiroir 5 disposé en regard, afin de permettre sa sortie et sa rentrée selon son axe horizontal de mobilité.On the other hand, this main carriage 22 comprises means for ensuring the unitary management of the drawer 5 arranged facing, to allow its output and re-entry along its horizontal axis of mobility.

Ces moyens de prise en charge sont illustrés sur les figures 7, 8 et 9.These means of care are illustrated on the figures 7 , 8 and 9 .

Ils consistent en un chariot motorisé 26 guidé sur des glissières 27 et mobile selon un axe parallèle à l'axe d'extraction des tiroirs 5. Ce chariot 26 comporte un crochet 28 qui est articulé en 29 autour d'un axe horizontal, et qui est associé à des moyens de commande en basculement (non représentés), par exemple du type actionneur ou électro-aimant associé à un ressort de rappel. Les moyens moteurs du chariot 26 peuvent consister en un moteur électrique pas à pas ou un moteur brushless avec contrôle du positionnement, associé à une courroie crantée d'entrainement.They consist of a motorized carriage 26 guided on slides 27 and movable along an axis parallel to the extraction axis of the drawers 5. This carriage 26 comprises a hook 28 which is articulated at 29 around a horizontal axis, and which is associated with tilt control means (not shown), for example of the actuator or electromagnet type associated with a return spring. The motor means of the carriage 26 may consist of a stepping electric motor or a brushless motor with positioning control, associated with a toothed drive belt.

Une fois le chariot 22 correctement positionné en regard de l'un des tiroirs 5, le crochet 28 est actionné de manière à venir coopérer avec l'un des orifices 11 du tiroir 5 pour assurer sa prise en charge, en vue de sa sortie, et ensuite de sa rentrée.Once the carriage 22 is correctly positioned opposite one of the drawers 5, the hook 28 is actuated so as to cooperate with one of the orifices 11 of the drawer 5 to ensure its handling, with a view to its exit, and then of his return.

Les moyens de commande en basculement du crochet 28 et la motorisation du chariot 26 sont gérés par le PC contrôle 4.The tilting control means of the hook 28 and the motorization of the carriage 26 are managed by the control PC 4.

De plus, comme on peut le voir sur les figures 7 et 8, l'actionneur linéaire 20 est lui-même monté mobile sur le chariot principal 22 par l'intermédiaire d'un chariot 32 coulissant sur une structure de glissières 32', en association avec une motorisation (par exemple du type moteur électrique pas à pas ou moteur brushless avec contrôle du positionnement, associé à une courroie crantée d'entraînement), cela horizontalement et perpendiculairement à l'axe d'extraction des tiroirs 5.Moreover, as can be seen from the figures 7 and 8 , the linear actuator 20 is itself mounted to move on the main carriage 22 via a carriage 32 sliding on a slide structure 32 ', in association with a motor (for example of the electric motor type step-by-step or brushless motor with positioning control, associated with a toothed drive belt), that horizontally and perpendicularly to the extraction axis of the drawers 5.

Ce déplacement de l'actionneur 20 est réalisé juste au-dessus du plan de mobilité du tiroir 5, et il est géré par le PC contrôle 4.This displacement of the actuator 20 is made just above the mobility plane of the drawer 5, and it is managed by the control PC 4.

On comprend qu'il permet le positionnement correct du doigt 21 de l'actionneur 20 en regard des différents compartiments d'une même ligne transversale de compartiments C du blister B porté par le support 12 en regard.It is understood that it allows the correct positioning of the finger 21 of the actuator 20 opposite the different compartments of the same cross section of compartments C blister B carried by the support 12 opposite.

En association avec le positionnement adapté du chariot 26, qui permet la sortie partielle ou complète du tiroir 5, et en ayant connaissance des coordonnées x-y des compartiments de conditionnement de tous les blisters B possibles, on peut ainsi positionner l'actionneur 20 en regard de n'importe quel compartiment de conditionnement C de tous les blisters B stockés dans l'armoire 2.In combination with suitable positioning of the carriage 26, which allows partial or complete exit of the tray 5, and with knowledge of the xy coordinates of all possible B blister packaging compartments, it is thus possible to position the actuator 20 facing any packaging compartment C of all the blisters B stored in the cabinet 2.

Les coordonnées x-y correspondantes des compartiments de conditionnement C sur les blisters B sont intégrés dans la mémoire RFID 18 de chaque support 12, ou dans la mémoire du PC contrôle 4.The corresponding xy coordinates of the conditioning compartments C on the blisters B are integrated in the RFID memory 18 of each support 12, or in the memory of the control PC 4.

Les moyens de détection 33 (figure 9), du type lecteur RFID par exemple, sont montés sur le chariot principal 22 de manière à permettre une communication avec l'un seulement des supports 12 (par l'intermédiaire de sa puce RFID 18), en fonction du positionnement dudit chariot 22.The detection means 33 ( figure 9 ), of the RFID reader type, for example, are mounted on the main carriage 22 so as to allow communication with only one of the supports 12 (via its RFID chip 18), depending on the positioning of said carriage 22.

Tel qu'illustré sur la figure 9, on remarque que ces moyens de détection 33 sont positionnés à l'avant du chariot 26, aptes à venir se placer juste devant le retour vertical 8 du tiroir 5 disposé en regard, de manière à se situer à proximité des moyens de détection 18 du support 12 correspondant. L'orifice central 10 de la façade 8 des tiroirs 5 est placé entre la puce 18 et le moyen de détection 33 ; il permet de faciliter la communication entre les deux (en limitant la présence de parois).As illustrated on the figure 9 , it is noted that these detection means 33 are positioned at the front of the carriage 26, able to be placed just in front of the vertical return 8 of the drawer 5 arranged opposite, so as to be located near the detection means 18 of the corresponding support 12. The central orifice 10 of the front 8 of the drawers 5 is placed between the chip 18 and the detection means 33; it facilitates communication between the two (by limiting the presence of walls).

Sur la figure 9, on remarque encore la présence de deux tétons 34, montés à l'avant du chariot 26 de part et d'autre des moyens de détection 33.On the figure 9 , we still note the presence of two pins 34, mounted at the front of the carriage 26 on either side of the detection means 33.

Ces deux tétons 34 sont destinés à venir pénétrer dans les orifices 9 du tiroir 5 disposé en regard, au moment de sa prise en charge pour sa manoeuvre, de manière à assurer son soutien et son positionnement en hauteur.These two pins 34 are intended to come into the orifices 9 of the drawer 5 disposed opposite, at the time of its handling for its maneuver, so as to ensure its support and positioning in height.

Comme on peut le voir sur les figures 1, 7 et 10, l'unité d'extraction 3 (et plus particulièrement le chariot 22) comporte des moyens 35, disposés sous l'actionneur 20, pour réceptionner par gravité les comprimés A extraits de leurs compartiments de conditionnement C.As can be seen on the figures 1 , 7 and 10 , the extraction unit 3 (and more particularly the carriage 22) comprises means 35, arranged under the actuator 20, for gravity receiving tablets A extracted from their packaging compartments C.

Dans le mode de réalisation illustré, ces moyens de réception 35 comprennent un carrousel motorisé 36, monté rotatif autour d'un axe vertical 36' et comportant une pluralité de conteneurs 37. Les différents conteneurs 37 sont répartis sur un cercle du carrousel 36, centré sur l'axe de rotation 36'.In the illustrated embodiment, these receiving means 35 comprise a motorized carousel 36, rotatably mounted around a vertical axis 36 'and comprising a plurality of containers 37. The various containers 37 are distributed over a circle of the carousel 36, centered on the axis of rotation 36 '.

De la sorte, tous les conteneurs 37 peuvent être positionnés à l'aplomb de l'actionneur linéaire 20, pour la réception des comprimés A éjectés.In this way, all the containers 37 can be positioned directly above the linear actuator 20, for the reception of the ejected tablets A.

Par exemple, le même conteneur 37 peut servir à la réception des différents comprimés constituant le lot de médicaments d'un patient, pour chacune de ses prescriptions journalières.For example, the same container 37 can be used to receive the various tablets constituting the batch of drugs of a patient, for each of its daily prescriptions.

Les conteneurs 37 sont avantageusement associés à un moyen d'obturation amovible de leur fond, permettant ainsi la libération par gravité du ou des comprimés d'un conteneur 37 considéré, lorsque ledit moyen d'obturation est désactivé.The containers 37 are advantageously associated with a removable closure means of their bottom, thus allowing gravity release of the tablet or tablets of a container 37 considered, when said shutter means is deactivated.

Comme illustré sur la figure 10, le moyen d'obturation amovible correspondant peut être constitué d'un plateau rotatif motorisé 38, disposé sous le carrousel 36 et constituant le fond des conteneurs 37, ce plateau motorisé 38 étant équipé d'un orifice unique 39, dont le positionnement est géré par le PC contrôle 4, pour assurer la vidange du conteneur souhaité.As illustrated on the figure 10 , the corresponding removable closure means may consist of a motorized rotary plate 38, disposed under the carousel 36 and constituting the bottom of the containers 37, this motorized plate 38 being equipped with a single orifice 39, whose positioning is managed by the control PC 4, to ensure the emptying of the desired container.

Les moyens de réception 35 peuvent être associés à des moyens de conditionnement de chaque lot de médicaments obtenu, par exemple en sachets, en association avec un marquage identificateur.The reception means 35 may be associated with means for packaging each batch of drugs obtained, for example in sachets, in association with an identifying marking.

Le PC contrôle 4 gère le fonctionnement des différentes motorisations associées à l'unité d'extraction 3, l'actionneur 20 et les moyens de réception 35, pour assurer la préparation de lots déterminés de médicaments, cela d'une manière rapide et fiable, à partir d'une programmation préétablie, et également à partir des informations communiquées par les moyens de détection 33.The control PC 4 manages the operation of the different engines associated with the extraction unit 3, the actuator 20 and the reception means 35, to ensure the preparation of predetermined batches of drugs, in a fast and reliable manner, from a pre-established programming, and also from the information communicated by the detection means 33.

Du fait des différentes informations reçues, et de la programmation associée, le PC contrôle 4 permet également une gestion très fine du stock de médicaments dans l'armoire 2.Due to the different information received, and the associated programming, the control PC 4 also allows a very fine management of the stock of drugs in the cabinet 2.

Les différents tiroirs 5 de l'armoire de stockage 2 peuvent être chacun associés à un repère visuel indiquant leur état vide (par exemple un repère lumineux de type LED).The different drawers 5 of the storage cabinet 2 may each be associated with a visual cue indicating their empty state (for example an LED light cue).

Un tel dispositif de préparation automatisée de lots de médicaments peut être utilisé de la manière suivante :

  • Chargement de la machine :
    • l'opérateur prend un tiroir vide ou avec un blister terminé
    • il retire le blister terminé
    • il place un blister neuf avec tous ses comprimés A dans le support 12 correspondant
    • il replace le support 12 sur l'un des tiroirs 5 de l'armoire 2 (un contact vient prévenir le PC contrôle 4 que le tiroir correspondant a été réalimenté)
    • au redémarrage de la machine, celle ci peut réaliser l'inventaire des blisters chargés dans les tiroirs pour alimenter sa base de données « blister » et calculer le stock des comprimés disponibles.
Such a device for automated preparation of batches of drugs can be used as follows:
  • Loading the machine:
    • the operator takes an empty drawer or with a finished blister
    • he removes the finished blister
    • he places a new blister with all his tablets A in the corresponding support 12
    • it puts the support 12 on one of the drawers 5 of the cabinet 2 (a contact comes to prevent the PC control 4 that the corresponding drawer has been refilled)
    • when the machine is restarted, it can carry out an inventory of the blisters loaded in the drawers to feed its blister database and calculate the stock of available tablets.

Programmation :

  • l'opérateur entre le programme de médicaments de chaque patient
  • le programme recherche dans la base de données « blister » les blisters présents dans la machine et le stock de comprimés disponible par rapport à la distribution demandée
  • on lance la réalisation des doses journalières ou demi-journalières
  • le dispositif lance un calcul des besoins à chaque cycle, pour savoir s'il dispose de suffisamment de stock de comprimés
  • à chaque cycle d'extraction d'un ou plusieurs comprimés, le programme met a jour, dans les moyens d'identification 18, le nombre de comprimés résiduel ainsi que, si nécessaire, des données additionnelles pour la sécurité ou la traçabilité (date, ....).
Programming:
  • the operator enters the drug program of each patient
  • the program searches the blister database for the blisters present in the machine and the stock of available tablets in relation to the requested distribution
  • we launch the realization of daily or half-daily doses
  • the device launches a calculation of the needs at each cycle, to know if it has enough stock of tablets
  • at each cycle of extraction of one or more tablets, the program updates, in the means of identification 18, the number of residual tablets as well as, if necessary, additional data for safety or traceability (date, ....).

Usage :

  • à chaque lancement, on obtient des lots nominatifs contenant les comprimés en nombre pour chaque prise
  • le lot obtenu (par exemple un sachet) comporte par exemple des indications sur le patient, le numéro de chambre, le médecin traitant, le rappel des médicaments contenus et éventuellement des instructions complémentaires,
  • on peut prévoir d'imprimer un code barres sur le sachet pour éventuellement le scanner vide une fois que les médicaments ont été distribués,
  • l'opérateur peut éventuellement lancer en isolé une dose supplémentaire ou additionnelle si le patient a égaré ses comprimés, ou s'il est nécessaire d'en rajouter, du fait de l'évolution du traitement.
Use :
  • at each launch, we obtain nominal batches containing the tablets in number for each take
  • the batch obtained (for example a sachet) comprises for example indications on the patient, the room number, the attending physician, the reminder of the drugs contained and possibly additional instructions,
  • it is possible to print a bar code on the bag to possibly the empty scanner once the drugs have been distributed,
  • the operator can possibly launch in isolation an additional dose or additional if the patient has lost his tablets, or if it is necessary to add, due to the evolution of treatment.

Ce type de dispositif permet des gains de temps appréciables, une gestion des stocks très fine, une grande traçabilité de la distribution des médicaments et une sécurité renforcée.This type of device allows appreciable time savings, a very fine stock management, a great traceability of the distribution of medicines and a reinforced security.

Il peut être utilisé dans les maisons de retraite, les hôpitaux, cliniques ou pharmacies. Il peut également être utilisé au domicile de personnes physiques, par exemple chez une personne âgée.It can be used in retirement homes, hospitals, clinics or pharmacies. It can also be used in the homes of natural persons, for example in an elderly person.

A titre de variante, on pourra prévoir une armoire de stockage de forme générale cylindrique, avec des tiroirs juxtaposés verticaux (associés à un actionneur linéaire mobile horizontalement).Alternatively, there may be a storage cabinet of cylindrical general shape, with vertical juxtaposed drawers (associated with a horizontally movable linear actuator).

Dans le cadre de dispositifs moins complexes (par exemple pour les particuliers), il est aussi possible de prévoir une juxtaposition d'une pluralité de supports de blisters dans un même plan, l'actionneur linéaire ayant alors la possibilité de se déplacer en x-y, dans un même plan horizontal, pour accéder très facilement au-dessus de chaque compartiment C des différents blisters B stockés.In the context of less complex devices (for example for individuals), it is also possible to provide a juxtaposition of a plurality of blister supports in the same plane, the linear actuator then having the possibility of moving in xy, in the same horizontal plane, to easily access above each compartment C of the various blisters B stored.

Claims (15)

Dispositif automatisé de préparation de lots de produits du type médicaments ou similaires, à partir de produits (A) conditionnés en blister (B), lequel blister (B) comporte au moins un compartiment fermé (C) pour la réception dudit produit (A), sous forme de comprimé ou de gélule notamment, lequel dispositif comporte : - une armoire de stockage (2) comprenant une pluralité de supports (12), chacun adapté pour la réception d'au moins un blister (B) de produit(s) (A), - une unité d'extraction (3) munie de moyens d'extraction (20) pour extraire, d'un blister (B) réceptionné par l'un desdits supports (12), l'un desdits produits (A) de son compartiment de conditionnement (C), - des moyens de positionnement (22, 23, 24, 26, 32), adaptés pour positionner automatiquement lesdits moyens d'extraction (20) en regard du compartiment (C) du blister (B) contenant le produit (A) à extraire, - des moyens électroniques/informatiques (4) pour gérer le positionnement et la mise en oeuvre desdits moyens d'extraction (20), et - des moyens (34) pour la réception dudit produit (A) extrait de son compartiment (C), caractérisé en ce que chaque blister (B) stocké dans ladite armoire de stockage (2), est associé à son propre support (12) constitué : - d'une embase (13) munie d'une pluralité d'ouvertures (15), pour recevoir l'une des faces dudit blister (B) associé, et - d'un couvercle (14) muni d'une pluralité d'ouvertures (16),
ladite embase (13) et ledit couvercle (14) étant aptes à prendre ledit blister (B) en sandwich, avec leurs ouvertures (15, 16) en correspondance et placées en regard d'un ou de plusieurs desdits compartiments (C) dudit blister (B), en vue d'assurer le maintien de ce dernier et éviter ses déformations au cours des phases d'extraction des produits (A),
et en ce que chaque support (12) comporte des moyens d'identification (18) aptes à coopérer avec des moyens de détection (33), en particulier pour la gestion du positionnement et de la mise en oeuvre desdits moyens d'extraction (20) par lesdits moyens électroniques/informatiques (4). Automated device for preparing batches of products of the medicament or similar type, from products ( A ) packaged in blister pack ( B ), which blister pack ( B ) comprises at least one closed compartment ( C ) for receiving said product ( A ) , in tablet or capsule form in particular, which device comprises: a storage cabinet (2) comprising a plurality of supports (12), each adapted for receiving at least one blister (B) of product (s) (A), - an extraction unit (3) provided with extraction means (20) for extracting, from a blister (B) received by one of said supports (12), one of said products (A) from its compartment conditioning (C), positioning means (22, 23, 24, 26, 32) adapted to automatically position said extraction means (20) facing the compartment ( C ) of the blister pack ( B ) containing the product ( A ) to be extracted, electronic / computer means (4) for managing the positioning and implementation of said extraction means (20), and means (34) for receiving said product ( A ) extracted from its compartment ( C ), characterized in that each blister ( B ) stored in said storage cabinet (2) is associated with its own support (12) consisting of: a base (13) provided with a plurality of openings (15) for receiving one of the faces of said associated blister ( B ), and a cover (14) provided with a plurality of openings (16),
said base (13) and said cover (14) being adapted to take said blister pack (B) sandwiched with their openings (15, 16) matched and placed opposite one or more of said compartments (C) of said blister ( B ), in order to ensure the maintenance of the latter and avoid its deformations during the extraction phases of the products ( A ),
and in that each support (12) comprises identification means (18) capable of cooperating with detection means (33), in particular for managing the positioning and the implementation of said extraction means (20). ) by said electronic / computer means (4). Dispositif selon la revendication 1, caractérisé en ce qu'il comporte une pluralité de supports (12) différents, dont les ouvertures (15, 16) d'embase (13) et de couvercle (14) sont adaptées, en nombre, emplacement et forme, aux différents types de blisters (B) susceptibles d'être utilisés, chaque support (12) étant adapté spécifiquement à un blister (B) particulier, et pouvant accueillir un ou plusieurs blisters (B).Device according to claim 1, characterized in that it comprises a plurality of different supports (12), the openings (15, 16) of base (13) and cover (14) are adapted, in number, location and form, the different types of blister ( B ) may be used, each support (12) being adapted specifically to a particular blister ( B ), and can accommodate one or more blisters ( B ). Dispositif selon la revendication 2, caractérisé en ce que chaque support (12) est équipé d'un couvercle (14) muni d'ouvertures (16) dont la forme et les dimensions correspondent à celles des compartiments (C) du blister (B) destiné à lui être associé, pour optimiser le positionnement dudit blister (B) sur son support (12) et assurer une fonction détrompeur.Device according to claim 2, characterized in that each support (12) is equipped with a cover (14) provided with openings (16) whose shape and dimensions correspond to those of the compartments ( C ) of the blister ( B ) intended to be associated with it, to optimize the positioning of said blister (B) on its support (12) and provide a keying function. Dispositif selon l'une quelconque des revendications 1 à 3, caractérisé en ce que lesdits moyens d'identification (18) ménagés sur chaque support de blister (12) consistent en un système de lecture/écriture à distance, de type puce RFID par exemple, apte à communiquer avec des moyens de détection adaptés (13), du type lecteur RFID par exemple, lesquels moyens d'identification (18) comportent une mémoire contenant des informations sur le type de produit (A) conditionné, et/ou sur la localisation desdits produits (A) sur la surface du blister (B), et/ou sur le stock des produits (A) restant sur le blister (B), et/ou sur l'emplacement des produits (A) restant sur blister (B), et/ou sur la méthode d'extraction des produits (A).Device according to any one of claims 1 to 3, characterized in that said identification means (18) provided on each blister carrier (12) consist of a remote read / write system, of the RFID chip type, for example , capable of communicating with suitable detection means (13), of the RFID reader type, for example, which identification means (18) comprise a memory containing information on the type of product ( A ) conditioned, and / or on the locating said products ( A ) on the surface of the blister ( B ), and / or on the stock of the products ( A ) remaining on the blister ( B ), and / or on the location of the products ( A ) remaining on blister ( B ), and / or the product extraction method ( A ). Dispositif selon l'une quelconque des revendications 1 à 4, caractérisé en ce que lesdits moyens d'extraction (20) comprennent un doigt d'extraction (21) adapté pour faire pression sur le compartiment (C) du blister (B) positionné en regard, afin d'expulser le produit (A) qui est conditionné dans ledit compartiment (C).Device according to any one of claims 1 to 4, characterized in that said extraction means (20) comprise an extraction finger (21) adapted to press the compartment ( C ) of the blister ( B ) positioned in look, in order to expel the product ( A ) which is packaged in said compartment ( C ). Dispositif selon la revendication 5, caractérisé en ce que le doigt d'extraction (21) consiste en un actionneur linéaire mobile en translation pour assurer l'expulsion du produit conditionné (A).Device according to claim 5, characterized in that the extraction finger (21) consists of a linear actuator movable in translation to ensure the expulsion of the packaged product ( A ). Dispositif selon la revendication 6, caractérisé en ce que le doigt d'extraction (21) est contrôlé dans sa course par des paramètres de positionnement et/ou de mesure d'effort, pour s'assurer de l'expulsion du produit (A) et éventuellement pour vérifier cette expulsion.Device according to claim 6, characterized in that the extraction finger (21) is controlled in its stroke by positioning and / or force measurement parameters, to ensure the expulsion of the product ( A ). and possibly to verify this expulsion. Dispositif selon l'une quelconque des revendications 1 à 7, caractérisé en ce que ladite unité d'extraction (3) est prévue mobile pour permettre le positionnement correct des moyens d'extraction (20) par rapport à l'ensemble desdits compartiments de blisters (C), associés aux différents supports (12) de ladite armoire de stockage (2), de manière à permettre l'extraction des produits (A) conditionnés dans les différents blisters (B) stockés, et en ce que lesdits moyens de détection (33) sont montés sur ladite unité d'extraction (3).Device according to any one of claims 1 to 7, characterized in that said extraction unit (3) is movably arranged to allow the correct positioning of the extraction means (20) with respect to all of said blister compartments ( C ), associated with the various supports (12) of said storage cabinet (2), so as to allow the extraction of the products ( A ) packaged in the various blisters ( B ) stored, and in that said detection means (33) are mounted on said extraction unit (3). Dispositif selon l'une quelconque des revendications 1 à 8, caractérisé en ce que les supports (12) de blisters (B) sont montés amovibles dans des logements d'accueil (5) ménagés dans l'armoire de stockage (2).Device according to any one of claims 1 to 8, characterized in that the supports (12) of blisters ( B ) are removably mounted in receiving housings (5) formed in the storage cabinet (2). Dispositif selon l'une quelconque des revendications 1 à 9, caractérisé en ce que l'armoire de stockage (2) comporte une pluralité de colonnes juxtaposées de plusieurs logements d'accueil superposés (5) pour les supports (12), lesquels logements d'accueil (5) se présentent chacun sous la forme d'un tiroir extractible selon un axe horizontal, ladite unité d'extraction (3) étant montée mobile horizontalement et verticalement, par l'intermédiaire d'un ou de plusieurs chariots (22, 23), devant ladite armoire de stockage (2), et comprenant des moyens (26, 28) permettant la prise en charge unitaire desdits tiroirs (5), pour assurer leur sortie et leur rentrée selon ledit axe horizontal, de manière, une fois ledit tiroir (5) en position au moins partiellement sortie, à permettre la mise en oeuvre desdits moyens d'extraction (20) des produits conditionnés (A).Device according to any one of claims 1 to 9, characterized in that the storage cabinet (2) comprises a plurality of columns juxtaposed with several superimposed receiving housings (5) for the supports (12), which housings (5) are each in the form of a drawer extractable along a horizontal axis, said extraction unit (3) being mounted movable horizontally and vertically, by means of one or more carriages (22, 23), in front of said storage cabinet (2), and comprising means (26, 28) for unitary handling of said drawers (5), to ensure their exit and retraction along said horizontal axis, so, once said drawer (5) in position at least partially out, to allow the implementation of said extraction means (20) of the packaged products ( A ). Dispositif selon la revendication 10, caractérisé en ce que ladite unité d'extraction (3) est montée mobile par l'intermédiaire d'un couple de chariots (22, 23), l'un coulissant horizontalement et l'autre coulissant verticalement, pour assurer son positionnement en regard de l'un desdits tiroirs (5) de l'armoire de stockage (2), lesdits moyens d'extraction (20) étant eux-mêmes montés mobiles sur ladite unité d'extraction (3), au moyen d'un chariot (32) déplaçable perpendiculairement à l'axe d'extraction des tiroirs (5), de manière à permettre leur positionnement en regard des différents compartiments (C) d'une même ligne transversale de compartiments (C) du blister (B) porté par le support (12) en regard.Device according to claim 10, characterized in that said extraction unit (3) is mounted movably by means of a pair of carriages (22, 23), one sliding horizontally and the other sliding vertically, for positioning it facing one of said drawers (5) of the storage cabinet (2), said extraction means (20) being themselves mounted movably on said extraction unit (3), by means of a carriage (32) movable perpendicularly to the extraction axis of the drawers (5), so as to allow their positioning opposite the different compartments ( C ) of the same cross section of compartments ( C ) of the blister ( B ) carried by the support (12) facing. Dispositif selon l'une quelconque des revendications 10 ou 11, caractérisé en ce que ladite unité d'extraction (3) comporte un chariot motorisé (26), mobile parallèlement à l'axe d'extraction des tiroirs (5), muni de moyens, par exemple en forme de crochet (28), permettant la prise en charge et la libération du tiroir (5) disposé en regard, pour assurer sa sortie et sa rentrée.Device according to any one of claims 10 or 11, characterized in that said extraction unit (3) comprises a motorized carriage (26), movable parallel to the extraction axis of the drawers (5), provided with means , for example in the form of a hook (28), allowing the loading and the release of the drawer (5) disposed opposite to ensure its exit and re-entry. Dispositif selon l'une quelconque des revendications 1 à 9, caractérisé en ce que l'armoire de stockage comporte une pluralité de logements d'accueil disposés dans un même plan horizontal pour les supports de blisters, ladite unité d'extraction étant montée mobile horizontalement et dans un même plan horizontal.Device according to any one of claims 1 to 9, characterized in that the storage cabinet comprises a plurality of receiving housings disposed in the same horizontal plane for the blister supports, said extraction unit being mounted horizontally movable and in the same horizontal plane. Dispositif selon l'une quelconque des revendications 1 à 13, caractérisé en ce que ladite unité d'extraction (3) comporte lesdits moyens de réception (34) du produit (A) extrait de son logement (C), lesquels moyens de réception (34) sont disposés sous lesdits moyens d'extraction (20), pour la réception desdits produits (A) par gravité.Device according to any one of claims 1 to 13, characterized in that said extraction unit (3) comprises said receiving means (34) of the product ( A ) extracted from its housing (C), which receiving means ( 34) are arranged under said extraction means (20), for receiving said products ( A ) by gravity. Dispositif selon la revendication 14, caractérisé en ce que lesdits moyens de réception (34) comprennent un carrousel (35) monté rotatif autour d'un axe vertical (36), comportant une pluralité de conteneurs (37) répartis sur un cercle centré sur ledit axe de rotation (36), lesdits conteneurs (37) comportant un moyen d'obturation amovible de leur fond, pour permettre la réception d'un ou de plusieurs produits (A) lorsque ledit moyen d'obturation amovible est activé, et la libération par gravité dudit ou desdits produits, lorsqu'il est désactivé.Device according to claim 14, characterized in that said receiving means (34) comprise a carousel (35) rotatably mounted around a vertical axis (36), comprising a plurality of containers (37) distributed on a circle centered on said axis of rotation (36), said containers (37) having a removable closure means of their bottom, to allow the reception of one or more products (A) when said removable closure means is activated, and releasing by gravity of said one or more products, when deactivated.
EP11306624.5A 2010-12-07 2011-12-07 Automated device for preparing batches of products, from blister-packed products, in particular drugs Not-in-force EP2463205B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1060166A FR2968198B1 (en) 2010-12-07 2010-12-07 AUTOMATED DEVICE FOR PREPARING LOTS OF PRODUCTS FROM PRODUCTS CONDITIONED IN BLISTERS, IN PARTICULAR DRUGS

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EP2463205A1 true EP2463205A1 (en) 2012-06-13
EP2463205B1 EP2463205B1 (en) 2014-03-26

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DE102015000112A1 (en) * 2015-01-14 2016-07-14 Stefan Stirnberg Automated system for patient-related storage and filling of drugs
WO2015142194A3 (en) * 2014-03-20 2019-09-19 Pete's Pill Popping Parlour Limited Apparatus for removing medication units from blister packs and methods therefor
CN111874392A (en) * 2020-07-15 2020-11-03 西南石油大学 Automatic medicine stripping device and using method
CN112109995A (en) * 2020-10-27 2020-12-22 齐鲁工业大学 Device for automatically and quantitatively extruding plate to contain medicines and working method thereof
WO2023194555A1 (en) * 2022-04-08 2023-10-12 Knapp Ag Method for operating a packaging device for packaging medicaments provided in tablet form, and method for operating a packaging device
EP4273060A1 (en) * 2022-04-08 2023-11-08 Knapp AG Method for operating a packaging device for packaging medicaments in tablet form and method for operating a packaging device

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CN108557131B (en) * 2018-04-28 2020-05-05 中国人民解放军陆军军医大学第一附属医院 Medication arranging and dispensing apparatus

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WO2015142194A3 (en) * 2014-03-20 2019-09-19 Pete's Pill Popping Parlour Limited Apparatus for removing medication units from blister packs and methods therefor
DE102015000112A1 (en) * 2015-01-14 2016-07-14 Stefan Stirnberg Automated system for patient-related storage and filling of drugs
CN111874392A (en) * 2020-07-15 2020-11-03 西南石油大学 Automatic medicine stripping device and using method
CN112109995A (en) * 2020-10-27 2020-12-22 齐鲁工业大学 Device for automatically and quantitatively extruding plate to contain medicines and working method thereof
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EP4273060A1 (en) * 2022-04-08 2023-11-08 Knapp AG Method for operating a packaging device for packaging medicaments in tablet form and method for operating a packaging device

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FR2968198B1 (en) 2013-07-05
EP2463205B1 (en) 2014-03-26

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