EP2453021A1 - Nouveaux composés indicateurs - Google Patents
Nouveaux composés indicateurs Download PDFInfo
- Publication number
- EP2453021A1 EP2453021A1 EP10190931A EP10190931A EP2453021A1 EP 2453021 A1 EP2453021 A1 EP 2453021A1 EP 10190931 A EP10190931 A EP 10190931A EP 10190931 A EP10190931 A EP 10190931A EP 2453021 A1 EP2453021 A1 EP 2453021A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- beta
- group
- donor
- compound
- containing moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 C*c(c1c(*)c(*)c(*)c(*)c11)c[n]1-c1c(C(*)=*)c(*)c(*)c(*)c1* Chemical compound C*c(c1c(*)c(*)c(*)c(*)c11)c[n]1-c1c(C(*)=*)c(*)c(*)c(*)c1* 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
Definitions
- the invention discloses of a new class of chromogenic and fluorogenic indicators responding to external stimuli such as biochemical environment, temperature or photo irradiation.
- the novel indicators offer broad potential in a wide array of applications, particularly for biological systems.
- Indicators are materials that produce a detectable signal in response to an external stimulus.
- Such stimuli typically include temperature, light (photo-labile or photochromic indicators), electric field (electrochromic indicators), pressure (piezoelectric indicators), ion concentration (e.g. pH indicators) and biochemical reactivity (e.g. enzyme indicators).
- a substituent attached to a principal moiety will be considered a ⁇ -donor if it has an electron lone pair that may enter into conjugation with a ⁇ -system of the principal moiety, thereby increasing the ⁇ -system by at least one atom.
- a lone pair is a valence electron pair without bonding or sharing with other atoms. Lone pairs are found in the outermost electron shell of an atom, so they are a subset of a molecule's valence electrons. They can be identified by examining the outermost energy level of an atom - lone electron pairs consist of paired electrons as opposed to single electrons, which may appear if the atomic orbital is not full. Electron pairs are therefore considered lone pairs if two electrons are paired but are not used in chemical bonding. Thus, the number of lone electrons plus the number of bonding electrons equal the total number of valence electrons from a compound.
- the labile group may be selected from a large variety of chemical entities and will generally be selected according to the type of stimulus to be detected with the indicator compound.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10190931A EP2453021A1 (fr) | 2010-11-11 | 2010-11-11 | Nouveaux composés indicateurs |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10190931A EP2453021A1 (fr) | 2010-11-11 | 2010-11-11 | Nouveaux composés indicateurs |
Publications (1)
Publication Number | Publication Date |
---|---|
EP2453021A1 true EP2453021A1 (fr) | 2012-05-16 |
Family
ID=43446467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10190931A Ceased EP2453021A1 (fr) | 2010-11-11 | 2010-11-11 | Nouveaux composés indicateurs |
Country Status (1)
Country | Link |
---|---|
EP (1) | EP2453021A1 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107868081A (zh) * | 2016-09-28 | 2018-04-03 | 吉林海格力斯医药生物科技发展有限公司 | 喹啉衍生物及其制备方法和用途 |
CN111793069A (zh) * | 2019-04-09 | 2020-10-20 | 清华大学 | 一种高效制备含有吲哚结构单元的稠环化合物的方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6555332B2 (en) | 1998-11-05 | 2003-04-29 | Biomerieux S.A. | Fluorescent detection method for microorganisms based on nitrocoumarins |
WO2010049450A1 (fr) * | 2008-10-31 | 2010-05-06 | Biosynth Ag | Sondes microbiennes non hydrolytiques |
WO2010128120A1 (fr) * | 2009-05-07 | 2010-11-11 | Biosynth Ag | Nouvelle plateforme indicatrice |
-
2010
- 2010-11-11 EP EP10190931A patent/EP2453021A1/fr not_active Ceased
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6555332B2 (en) | 1998-11-05 | 2003-04-29 | Biomerieux S.A. | Fluorescent detection method for microorganisms based on nitrocoumarins |
WO2010049450A1 (fr) * | 2008-10-31 | 2010-05-06 | Biosynth Ag | Sondes microbiennes non hydrolytiques |
WO2010128120A1 (fr) * | 2009-05-07 | 2010-11-11 | Biosynth Ag | Nouvelle plateforme indicatrice |
Non-Patent Citations (1)
Title |
---|
JAMES, A. L.; J. D. PERRY ET AL.: "Fluorogenic substrates for the detection of microbial nitroreductases.", LETTERS IN APPLIED MICROBIOLOGY, vol. 33, no. 6, 2001, pages 403 - 408 |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107868081A (zh) * | 2016-09-28 | 2018-04-03 | 吉林海格力斯医药生物科技发展有限公司 | 喹啉衍生物及其制备方法和用途 |
CN107868081B (zh) * | 2016-09-28 | 2020-08-11 | 吉林海格力斯医药生物科技发展有限公司 | 喹啉衍生物及其制备方法和用途 |
CN111793069A (zh) * | 2019-04-09 | 2020-10-20 | 清华大学 | 一种高效制备含有吲哚结构单元的稠环化合物的方法 |
CN111793069B (zh) * | 2019-04-09 | 2021-05-18 | 清华大学 | 一种高效制备含有吲哚结构单元的稠环化合物的方法 |
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Legal Events
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PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED |
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18R | Application refused |
Effective date: 20120603 |