EP2443346A2 - Pumpen und armaturen mit sensoren - Google Patents
Pumpen und armaturen mit sensorenInfo
- Publication number
- EP2443346A2 EP2443346A2 EP10722958A EP10722958A EP2443346A2 EP 2443346 A2 EP2443346 A2 EP 2443346A2 EP 10722958 A EP10722958 A EP 10722958A EP 10722958 A EP10722958 A EP 10722958A EP 2443346 A2 EP2443346 A2 EP 2443346A2
- Authority
- EP
- European Patent Office
- Prior art keywords
- component
- sensor
- fluid
- evaluation unit
- deposit formation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012530 fluid Substances 0.000 claims abstract description 73
- 238000011156 evaluation Methods 0.000 claims abstract description 26
- 238000000034 method Methods 0.000 claims description 38
- 230000015572 biosynthetic process Effects 0.000 claims description 35
- 238000004140 cleaning Methods 0.000 claims description 29
- 230000008569 process Effects 0.000 claims description 24
- 238000005259 measurement Methods 0.000 claims description 12
- 239000000758 substrate Substances 0.000 claims description 11
- 230000010363 phase shift Effects 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 description 18
- 238000011010 flushing procedure Methods 0.000 description 13
- 239000000463 material Substances 0.000 description 11
- 239000000047 product Substances 0.000 description 10
- 239000012459 cleaning agent Substances 0.000 description 8
- 238000000576 coating method Methods 0.000 description 8
- 239000011248 coating agent Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 239000010410 layer Substances 0.000 description 5
- 238000009825 accumulation Methods 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 239000002028 Biomass Substances 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000013452 biotechnological production Methods 0.000 description 2
- 238000012824 chemical production Methods 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 241000206761 Bacillariophyta Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229910001060 Gray iron Inorganic materials 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 238000011112 process operation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04D—NON-POSITIVE-DISPLACEMENT PUMPS
- F04D27/00—Control, e.g. regulation, of pumps, pumping installations or pumping systems specially adapted for elastic fluids
Definitions
- the invention relates to a component for flow-guiding systems, wherein the component is influenced by a fluid located within the fluid-carrying system and the component is designed as a power and / or working machine or as a valve and a sensor is placed in the component. Furthermore, the invention relates to a method for detecting deposits on walls of such components.
- Pumps are designed as units with differently coupled drive motors, as compact motor pump units or other known types.
- the components are integrated into flow-leading systems.
- This may be a piping system of larger plants, such as chemical or biotechnological production plants or power plants, act.
- the fluids may be liquid or gaseous, wherein the liquids or gases may also be mixed with solid particles.
- the invention is preferably used in liquids, wherein the application of the invention is particularly suitable for aqueous solutions.
- An influence of the fluid through the component can be done in different ways.
- the fluid can, as is the case for example with a centrifugal pump, be supplied by the component energy.
- the fluid is first accelerated by the impeller of the pump.
- the added kinetic energy is then converted into pressure energy.
- the fluid can also be influenced by the component in terms of its volume flow or its flow velocity. This happens, for example, in an embodiment of the component as a valve. By varying the position of the shut-off of the valve, the flow cross-section is changed, the fluid must pass. This allows the volume flow to be regulated.
- Such components are often provided with sensors which determine states or specific material properties of the fluid.
- So pumps can be equipped with a pressure sensor.
- Sensors are also used in valves.
- DE 197 25 376 A1 describes a strand regulating fitting for regulating volume flows.
- a sensor is integrated in a flow housing. The sensor is connected to an evaluation unit.
- the coverings may be either inorganic or organic.
- inorganic deposits are carbonates, oxides or hydroxides, which precipitate as scale, rust or staining on the walls of the component.
- the most important organic deposits are biofilms.
- the vegetation is caused by biomass and impurities trapped in the biomass.
- Bacteria, fungi, yeasts, diatoms and protozoa are just a few organisms that cause the buildup of biomass. If the biofouling caused by these organisms is not controlled, it interferes with process operations and adversely affects product quality.
- strict purity levels must be adhered to, since contamination with bacteria or metabolic products of microorganisms in the consumer can lead to health problems.
- the components on which deposits form can be made of different materials, such as stainless steel, gray cast iron, ceramic or plastic.
- the surface structure influences the formation of deposits, with macroscopically rough surfaces generally offering a better attack surface than smooth surfaces.
- the flow velocity also influences the formation of deposits. This is how biobags are produced preferentially in areas with a slow flow.
- the object of the present invention is to provide a component with a sensor which influences a fluid contained within a flow-carrying system and at the same time records and quantitatively evaluates the deposit formation. It is another object of the invention to develop a method for the detection of deposits on walls of such components. This object is achieved in that the sensor comprises at least one transmitter and at least one receiver, wherein the transmitter generates acoustic waves on the surface of the sensor and the receiver perceives these acoustic waves and the sensor generates signals for an evaluation that by comparison determined with reference data, the degree of deposit formation in the component.
- the surface of the sensor preferably consists of a piezoelectric substrate on which comb electrodes are applied as transmitter and receiver.
- a comb electrode forms a first interdigital transducer (IDT), the so-called transmitter-interdigital transducer (transmitter-IDT), which generates a surface wave on the piezoelectric substrate.
- the second comb electrode forms a second interdigital transducer, the so-called receiver-interdigital transducer (receiver-IDT). After passing through a certain measuring distance, the surface waves generated by the transmitter are perceived by the receiver.
- the substrate may be made of any piezoelectric suitable for wave excitation.
- electroacoustic waves are excited due to the piezoelectricity of the substrate.
- a wave excited by the transmitter IDT travels along the surface of the substrate and generates in the receiver IDT a high frequency AC voltage that is electronically evaluated.
- the formation of a deposit on the surface of the sensor affects the propagation velocity of the waves.
- the degree of deposit formation can be determined in different ways. For example, conclusions can be drawn on the degree of deposit formation from phase and / or amplitude displacement of the waves. In this case, the phase shift is determined in measurements with a fixed frequency. Depending on the base layer, the system has a natural frequency. This shifts when the base layer is changed, whereby the frequency shift is detected. By shifting the resonance frequency, it is thus possible to draw conclusions about the mass of surface on the sensor surface
- the determination of the degree of deposit formation is a comparison of the measured data with reference data.
- data are used as a reference for a coating-free sensor surface.
- the process conditions correspond to the conditions in the reference measurement which are also present when carrying out the measurement of deposit formation
- the sensor is preferably formed as a compact unit It has proven to be favorable to provide a wall of the component with a hole into which the sensor is inserted accurately fit In some cases, it proves to be particularly favorable if the sensor flush in the Thus, it can be integrated into pumps or valves without disturbing the flow characteristics of the component. In this case, the sensor is tangentially impinged on. This arrangement is particularly suitable for coatings which are preferably formed at high flow velocities
- the sensor may also be advantageous to arrange the sensor backward relative to the current-carrying wall of the component. This creates a cavity in front of the sensor in which the fluid flows more slowly. In the cavity, an eddy current is formed, which causes the sensor surface to be flowed at different angles. These factors may require the formation of a deposit, which applies in particular to biobelage. With such an arrangement, the sensor is located at a dirty point of the component. Thus, the formation of deposits in the component can be detected early and corresponding countermeasures can be initiated
- the degree of deposit formation can be given, for example, as the mass of the covering layer which forms on the sensor. As the formation of deposits progresses, the height of the covering layer also increases. It is also conceivable that the structure of the covering changes as the formation of the covering layer progresses and becomes increasingly more compact. In this case, the physical size of the density of the coating layer would be a measure of the degree of deposit formation.
- the sensor generates signals and forwards them to an evaluation unit.
- the evaluation unit detects the signals of the sensor and determines the degree of deposit formation via an algorithm.
- the signals which the sensor forwards to the evaluation unit flow into the algorithm as measurement signals.
- the algorithm uses reference data to establish a relationship between the sensor data and the degree of deposit formation.
- the evaluation unit can also be integrated in the sensor, for example in the form of a processor.
- a signal is emitted by the evaluation unit when a limit value which corresponds to a certain degree of deposit formation is exceeded. It proves to be particularly advantageous if this signal leads to the triggering of a process that causes a cleaning of the walls.
- the processing of the sensor signal and / or the triggering of the cleaning process can be carried out by means of a process control system.
- the production cycle as long as possible and the cleaning cycle can be driven as short as necessary, without causing a deterioration of the product quality.
- the operators of the production facilities no longer need to rely on empirical values, but have reliable measurement data that are recorded continuously.
- the cleaning process is initiated when a certain degree of deposit formation has been exceeded. This prevents the cleaning process neither too late is initiated too early. On the one hand, this protects the product quality from being negatively influenced by an overly advanced deposit formation. On the other hand, production time is prevented from being lost.
- the coating recedes continuously due to the use of cleaning agents.
- the remaining mass of coating is continuously recorded.
- the cleaning process is carried out until the coating is completely removed, or falls below a predetermined limit.
- the cleaning agent is rinsed out of the process with a rinsing fluid, for example a rinsing liquid.
- the inventive component prevents the cleaning process or the rinsing process from being carried out unnecessarily long. Thus, a waste of detergent, flushing fluid and production time is avoided. Conversely, it is ensured that the cleaning process is terminated only when the pipes are largely free of coating. This ensures a high product quality.
- Changes in the physical boundary conditions at the sensor surface affect the propagation velocity of the surface waves. Therefore, it is also possible with the component according to the invention to detect the type of fluid flowing past the sensor. Thus, it can be determined with the sensor, for example, whether a necessary for the production process fluid, a cleaning agent or a flushing fluid flows through the component.
- a cleaning agent is added to the process, which reaches the sensor only after a certain dead time.
- the dead time is the greater the longer the flow paths that must be traveled from the point of introduction of the cleaning agent to the sensor. Since the sensor can detect a change in the type of fluid flowing past its surface, the method according to the invention can be used to determine the time from which the cleaning agent arrives at the sensor. After the end of the cleaning process, the component is rinsed, whereby the cleaning agent is removed from the component. Only after a certain dead time, the cleaning agent present in the lines is again completely rinsed out of the component. After the rinsing process, the fluids necessary for the production process are supplied again. With the sensor, the time can be detected, from which the flushing fluid has been completely removed from the component. This avoids that the product is contaminated by residual amounts of flushing fluid.
- a particular advantage of the invention is that the sensor can be used not only for determining the formation of deposits in the component, but at the same time for determining the viscosity or the temperature of the fluid.
- the propagation velocity of the surface waves depends on the viscosity and the temperature of the fluid. According to the invention, it is thus a component that combines several measuring methods integratively.
- the component contains at least one further sensor.
- This sensor determines state variables of the fluid that can influence the pad measurements.
- the viscosity or the temperature of the fluid can influence the measurements of the degree of deposit formation.
- different measuring methods can be used for the additional sensors.
- it may be a temperature-dependent resistor or a thermocouple.
- the additional sensors also pass their signals to the evaluation unit.
- the evaluation unit calculates the influence on the measurements of the degree of deposit formation by fluctuations within the state variables of the fluid. By means of a data comparison, the first sensor can thus be calibrated with respect to the lining measurement.
- Fig. 4 A diagram showing the change between production, cleaning and rinsing cycles.
- a component 1 for flow-leading systems, wherein with the component 1, a fluid located within the fluid-carrying system is influenced.
- the component 1 is designed as a centrifugal pump.
- the promotion of the fluid takes place with an impeller 10 which is mounted on a drive shaft 11.
- the fluid enters the pump 1 through the suction nozzle 12 arranged in the rotation axis and is accelerated by the rotating impeller 10.
- the flow-guiding system can be, for example, a piping system in which the component 1 is installed.
- a sensor 3 is integrated in a wall 2 of the component 1.
- the surface 4 of the sensor 3 is in contact with the fluid.
- a connecting means 5 is fixed, via which the sensor 3 is in communication with an evaluation unit 6.
- the connecting means 5 may be formed as plug-in, screw, or an otherwise conventional connection means for producing electrical connections.
- the power supply of the sensor 3 can be done via the connecting means 5.
- the sensor 3 projects with its surface 4 in the Pressure-side Radforceraum of the component 1
- the sensor 3 detects deposits that form on its surface 4
- At least a portion of the surface 4 of the sensor 3 is formed as a piezoelectric substrate 7 on the piezoelectric substrate 7, a transmitter 8 and a receiver 9 are arranged It involves two designed as interdigital transducer comb electrodes on a fixed frequency set oscillator generates an electrical alternating signal with constant amplitude It has proved to be advantageous if the oscillator is part of the sensor 3 and is arranged in Se ⁇ sorkorper About the transmitter 8, a surface wave in the piezoelectric material 7 is generated After passing through a measuring section the acoustic signal is converted via the receiver 9 into an electrical alternating current signal. A deposit formation leads to a change in the propagation velocity and the amplitude of the surface wave. The resulting phase change of the signal compared to the coating-free measurement is determined by the evaluation unit 6 is recorded
- FIG. 3 shows another component 1 according to the invention.
- the component 1 is a valve which influences a fluid contained within a flow-carrying system. Through the component 1, the flow rate of the fluid can be regulated by means of an actuator 15, here as a handwheel When the shut-off body changes position, the flow cross-section in the component 1 is changed.
- the component 1 can be, for example, a valve, a slide, a tap or a flap.
- the component 1 is part of a current-carrying system
- a current-carrying system For example, be a piping system of a larger system, such as a chemical production plant, a biotechnological production plant or a power plant with the component 1, the fluid contained within the stromungsbowenden system is influenced by the volume flow or the flow rate
- the sensor 3 is installed in a wall 2 of the component 1.
- the current-carrying wall 2 has on the wall Outside via a material accumulation 16
- An opening 17 is introduced into the material accumulation 16.
- the sensor 3 is recessed to form an interior 18.
- the interior 18 is located within the material accumulation 16.
- the opening 17 is a simple bore within the material accumulation Due to the recessed arrangement of the sensor surface 4, a secondary vortex is formed inside the interior 18.
- the surface 4 of the sensor 3 is at least partially composed of a piezoelectric substrate 7.
- a transmitter 8 and a receiver 9 are positioned on the piezoelectric substrate 7 an output of the sensor 3, a connecting means 5 is connected, which is in communication with an evaluation unit 6
- the connecting means 5 may be formed as a plug, screw, or an otherwise conventional connection means for making electrical connections Alternatively to a fixed connection means, a transmission of Signals are transmitted by radio
- the evaluation unit 6 can be supplied by an external voltage source and / or have an integrated voltage source. These can be accumulators, batteries, power units, thermoelectric generators, solar cells or the like.
- the sensor 3 detects, in the manner already described , Covering on its surface 4
- FIG. 4 shows a diagram in which the paving composition on the sensor surface 4 and the concentrations of production, cleaning and rinsing fluid are plotted as a function of time.
- the production process begins at the instant t.
- the fluid for example a liquid, flows to the sensor 3. with a constant product concentration over The product concentration is shown as a solid line 19
- the line 19, representing the product concentration, is compared with the line 20, to show the coating mass, executed thinner From a time ti, a deposit begins on the Sensor surface 4 build.
- time t 2 is above a specific, labeled on the left ordinate with a value "1", the limit value of lining material, a cleaning fluid such as a cleaning liquid, optionally in the process.
- the cleaning fluid reaches the sensor 3 only at the time t 3.
- the time span t 3 -t 2 is the dead time which the cleaning fluid needs to reach from its point of introduction to the sensor 3.
- the concentration of cleaning fluid is shown as a dashed line 21 shown.
- the concentration of production fluid from. the lining material initially increases and reaches at the time L t maximum. from then on, the lining material is mined. from time t 5 to the production fluid completely displaced by the cleaning fluid. the cleaning fluid has its maximum concentration reached, the level of pavement continues to decrease until time t 6 At t 6 , flushing fluid is passed into the process.
- the concentration of flushing fluid is shown as line 22, which consists of a sequence of one stroke and two points.
- the flushing fluid reaches the sensor 3 only at the time t 7 .
- the time period t 7 -t 6 is a dead time which requires the flushing fluid to cover the path from the point of introduction to the sensor 3.
- the concentration of flushing fluid at the sensor 3 increases.
- the concentration of cleaning fluid decreases.
- the concentration of flushing fluid reached its maximum while the cleaning fluid was completely displaced. In order to ensure that no cleaning fluid is left in the process, the flushing process continues even after the cleaning fluid has dropped to a zero concentration, thus providing a temporal safety margin. Then the process is switched back to production fluid.
- the production fluid obtained at the time t 9 the sensor 3.
- the concentration of production fluid increases up to the time tio, while the concentration of flushing fluid decreases. From time tio on the sensor 3, the flushing fluid is completely displaced from the production fluid.
- the sensor 3 detects the mass of coating on its surface 4. As already stated, the sensor 3 can continue to detect whether production, cleaning or rinsing fluid flows past it.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Volume Flow (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Control Of Positive-Displacement Pumps (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009025153A DE102009025153A1 (de) | 2009-06-17 | 2009-06-17 | Pumpen und Armaturen mit Sensoren |
| PCT/EP2010/003388 WO2010145762A2 (de) | 2009-06-17 | 2010-06-04 | Pumpen und armaturen mit sensoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP2443346A2 true EP2443346A2 (de) | 2012-04-25 |
| EP2443346B1 EP2443346B1 (de) | 2017-10-18 |
Family
ID=43216917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP10722958.5A Not-in-force EP2443346B1 (de) | 2009-06-17 | 2010-06-04 | Pumpen und armaturen mit sensoren |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2443346B1 (de) |
| DE (1) | DE102009025153A1 (de) |
| DK (1) | DK2443346T3 (de) |
| ES (1) | ES2648244T3 (de) |
| WO (1) | WO2010145762A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102013218827A1 (de) * | 2012-09-22 | 2014-03-27 | Ksb Aktiengesellschaft | Strangregulierarmatur |
| DE102014113655A1 (de) * | 2014-09-22 | 2016-03-24 | Bürkert Werke GmbH | Ventilgehäuse |
| DE102016203425A1 (de) * | 2016-03-02 | 2017-09-07 | Bestsens Ag | Zahnradpumpe und Verfahren zum Überwachen einer Zahnradpumpe |
| DE102019004263A1 (de) * | 2019-06-18 | 2020-12-24 | KSB SE & Co. KGaA | Kreiselpumpe und Verfahren zur Zustandserkennung einer Kreiselpumpe |
| DE102020209856A1 (de) * | 2020-08-05 | 2022-02-10 | Robert Bosch Gesellschaft mit beschränkter Haftung | Verfahren zum Bewerten des Zustands eines Sensors sowie Sensorsystem und Verfahren zum Betreiben des Sensorsystems |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6191509A (ja) * | 1984-10-12 | 1986-05-09 | Fuji Electric Co Ltd | 管内スケ−ル厚さの測定方法 |
| US4628736A (en) * | 1985-01-14 | 1986-12-16 | Massachusetts Institute Of Technology | Method and apparatus for measurement of ice thickness employing ultra-sonic pulse echo technique |
| DE19725376A1 (de) | 1996-12-21 | 1998-06-25 | Klein Schanzlin & Becker Ag | Strangregulierarmatur |
| US6035717A (en) * | 1998-05-12 | 2000-03-14 | Krautkramer Branson, Inc. | Method and apparatus for measuring the thickness of a coated material |
| US20070006656A1 (en) * | 2005-07-11 | 2007-01-11 | General Electric Company | System and method for monitoring deposition within tubes of a heating system |
| US7673525B2 (en) * | 2007-01-09 | 2010-03-09 | Schlumberger Technology Corporation | Sensor system for pipe and flow condition monitoring of a pipeline configured for flowing hydrocarbon mixtures |
-
2009
- 2009-06-17 DE DE102009025153A patent/DE102009025153A1/de not_active Withdrawn
-
2010
- 2010-06-04 EP EP10722958.5A patent/EP2443346B1/de not_active Not-in-force
- 2010-06-04 WO PCT/EP2010/003388 patent/WO2010145762A2/de not_active Ceased
- 2010-06-04 DK DK10722958.5T patent/DK2443346T3/en active
- 2010-06-04 ES ES10722958.5T patent/ES2648244T3/es active Active
Non-Patent Citations (1)
| Title |
|---|
| See references of WO2010145762A2 * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE102009025153A1 (de) | 2010-12-30 |
| DK2443346T3 (en) | 2018-01-02 |
| WO2010145762A3 (de) | 2011-03-03 |
| EP2443346B1 (de) | 2017-10-18 |
| WO2010145762A2 (de) | 2010-12-23 |
| ES2648244T3 (es) | 2017-12-29 |
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