EP2412357A1 - Medicinal composition container - Google Patents
Medicinal composition container Download PDFInfo
- Publication number
- EP2412357A1 EP2412357A1 EP10756162A EP10756162A EP2412357A1 EP 2412357 A1 EP2412357 A1 EP 2412357A1 EP 10756162 A EP10756162 A EP 10756162A EP 10756162 A EP10756162 A EP 10756162A EP 2412357 A1 EP2412357 A1 EP 2412357A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- pharmaceutical composition
- encapsulating
- swallowing
- item
- aforementioned
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 227
- 239000000126 substance Substances 0.000 claims abstract description 136
- 238000003860 storage Methods 0.000 claims abstract description 130
- 239000000463 material Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000004615 ingredient Substances 0.000 claims description 9
- 239000000155 melt Substances 0.000 claims description 9
- 235000015110 jellies Nutrition 0.000 claims description 6
- 239000008274 jelly Substances 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 4
- 239000008107 starch Substances 0.000 claims description 4
- 235000019698 starch Nutrition 0.000 claims description 4
- 230000000694 effects Effects 0.000 description 27
- 239000003814 drug Substances 0.000 description 20
- 229940079593 drug Drugs 0.000 description 20
- 230000009747 swallowing Effects 0.000 description 10
- 238000000034 method Methods 0.000 description 8
- 230000037406 food intake Effects 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 239000000057 synthetic resin Substances 0.000 description 6
- 229920003002 synthetic resin Polymers 0.000 description 6
- 239000002775 capsule Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 238000005520 cutting process Methods 0.000 description 4
- 235000019658 bitter taste Nutrition 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 239000010408 film Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 229920001684 low density polyethylene Polymers 0.000 description 2
- 239000004702 low-density polyethylene Substances 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 241000206672 Gelidium Species 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920001218 Pullulan Polymers 0.000 description 1
- 239000004373 Pullulan Substances 0.000 description 1
- UGXQOOQUZRUVSS-ZZXKWVIFSA-N [5-[3,5-dihydroxy-2-(1,3,4-trihydroxy-5-oxopentan-2-yl)oxyoxan-4-yl]oxy-3,4-dihydroxyoxolan-2-yl]methyl (e)-3-(4-hydroxyphenyl)prop-2-enoate Chemical compound OC1C(OC(CO)C(O)C(O)C=O)OCC(O)C1OC1C(O)C(O)C(COC(=O)\C=C\C=2C=CC(O)=CC=2)O1 UGXQOOQUZRUVSS-ZZXKWVIFSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229920000617 arabinoxylan Polymers 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 239000000805 composite resin Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 235000011950 custard Nutrition 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- -1 polyethylene terephthalate Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0015—Devices specially adapted for taking medicines
- A61J7/0046—Cups, bottles or bags
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/06—Ampoules or carpules
- A61J1/067—Flexible ampoules, the contents of which are expelled by squeezing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0015—Devices specially adapted for taking medicines
- A61J7/0053—Syringes, pipettes or oral dispensers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/3261—Flexible containers having several compartments
- B65D81/3266—Flexible containers having several compartments separated by a common rupturable seal, a clip or other removable fastening device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2024—Separating means having peelable seals
Definitions
- This invention relates to a pharmaceutical composition container; more specifically, to a pharmaceutical composition container so configured as to allow the reduction of the residual quantity of the pharmaceutical composition.
- Patent document 1 discloses a multi-chamber container.
- This multi-chamber container is so partitioned into a plurality of spaces as to enable the spaces to be interconnected with each other.
- the spaces are sealed in such a state that they can be interconnected with each other by means of force applied from the outside.
- a granular agent is stored in a tightly sealed state in any of the spaces.
- a thick fluid substance is stored in a tightly sealed state in one or more other spaces. After interconnecting the spaces with each other and gathering and mixing the granular agent with the thick fluid substance, it is possible to take out the mixture from a take-out port provided on any of the spaces.
- the technical issue addressed by this invention was drafted to solve the abovementioned problem, and the purpose of the invention is to provide a pharmaceutical composition container that allows the reduction of the residual quantity of the pharmaceutical composition.
- the pharmaceutical composition containers (10, 11, 12, 14, 15, 16, 18) are equipped with a plurality of spaces (30, 32, 34, 36, 38, 100, 102, 104, 106, 110, 112, 114, 116, 150).
- the portions (70, 72, 76) between two adjoining spaces are sealed.
- the portions (70, 72, 76) between two adjoining spaces open when force is applied from the outside of the pharmaceutical composition containers (10, 11, 12, 14, 15, 16, 18).
- a swallowing-aid substance (40) is stored in swallowing-aid substance storing chambers (30, 100, 102, 104, 106) which are at least one of the spaces.
- Encapsulating items (42, 120) are stored in encapsulating-item storing chambers (32, 110, 112, 114) which each are at least one of the spaces.
- the encapsulating items (42, 120) contain the pharmaceutical composition (80) .
- At least the surface of the encapsulating items (42, 120) melts in the ingredients of the swallowing-aid substance (40).
- the pharmaceutical composition containers (10, 11, 12, 14, 15, 16, 18) are provided with a predetermined aperture part (60) .
- the predetermined aperture part (60) is a portion where an aperture is to be formed.
- the aperture interconnects the outside of the pharmaceutical composition containers (10, 11, 12, 14, 15, 16, 18) with the spaces (30, 32, 34, 36, 38, 100, 102, 104, 106, 110, 112, 114, 116, 150).
- the portions (70, 71, 72, 76) between two adjoining spaces are sealed.
- the portions (70, 71, 72, 76) between two adjoining spaces open when force is applied from the outside of the pharmaceutical composition containers (10, 11, 12, 14, 15, 16, 18) .
- By the opening of the portions (70, 71, 72, 76) between two adjoining spaces it is possible to guide the swallowing-aid substance (40) from the swallowing-aid substance storage chambers (30, 100, 102, 104, 106) to the encapsulating-item storage chambers (32, 110, 112, 114) .
- the encapsulating items (42, 120) will enter the mouth of the person with swallowing difficulties while being enclosed in swallowing-aid substance (40).
- the encapsulating items (42, 120) are swallowed. Since the pharmaceutical composition (80) is inside the encapsulating items (42, 120), the pharmaceutical composition (80) inside the encapsulating items (42, 120) is pushed out at the same time when the encapsulating items (42, 120) are pushed out.
- the residual quantity of the pharmaceutical composition (80) in the encapsulating-item storage chambers (32, 110, 112, 114) is reduced as compared to the case where the pharmaceutical composition is not inside the encapsulating items (42, 120) .
- the surface of the encapsulating items (42, 120) melts in the ingredients of the swallowing-aid substance (40)
- the surface of the encapsulating items (42, 120) will melt after the swallowing-aid substance (40) is guided into the encapsulating-item storage chambers (32, 110, 112, 114).
- the encapsulating items (42, 120) can easily be swallowed even by a person with swallowing difficulties because the encapsulating items (42, 120) are enclosed in the swallowing-aid substance (40) and the surface of encapsulating items (42, 120) has melted. That being the case, the pharmaceutical composition (80) is also swallowed with the swallowing of the encapsulating items (42, 120).
- the abovementioned swallowing-aid substance (40) contain water.
- the material of the encapsulating items (42, 120) is a water-soluble substance. This reduces the probability that swallowing becomes difficult because the surfaces of the encapsulating items (42, 120) have not sufficiently melted.
- the abovementioned swallowing-aid substance (40) be a water-containing jelly.
- the water-soluble substance be starch.
- a chamber (116) which is at least one of the abovementioned spaces, is disposed between the swallowing-aid substance storage chamber (102) and the encapsulating-item storage chamber (114). This is because the provision of a chamber (116) reduces the probability that the swallowing-aid substance (40) comes into contact with the encapsulating item (42) when the two adjoining spaces (102, 114) are interconnected against the will of the user or handler of the pharmaceutical composition container (15). Reducing that probability also lowers the probability that the encapsulating item (42) melts before the ingestion of the pharmaceutical composition (80). As a result, the pharmaceutical composition container (15) will be easy to preserve and easy to handle.
- the abovementioned encapsulating item (42) be tightly sealed.
- tight sealed in this description means being sealed in such a manner that no gaps exist.
- the pharmaceutical composition containers (210, 260, 400, 500) are equipped with at least three spaces (230, 232, 234, 236, 280, 282, 284, 286, 422, 424, 426, 520, 522, 524, 526).
- the portions (240, 242, 244, 300, 302, 304, 440, 442, 444, 540, 542, 544) between two adjoining spaces are sealed.
- the portions (240, 242, 244, 300, 302, 304, 440, 442, 444, 540, 542, 544) between two adjoining spaces open when force is applied from the outside of the pharmaceutical composition containers (210, 260, 400, 500).
- a swallowing-aid substance (40) is stored in swallowing-aid substance storage chambers (230, 280, 520) which each are at least one of the spaces.
- An encapsulating item (212) is stored in encapsulating-item storage chambers (232, 234, 282, 284, 422, 424, 522, 524) which each are at least one of the spaces.
- the encapsulating item (212) contains the pharmaceutical composition (80). At least the surface of the encapsulating item (212) melts in the ingredients of the swallowing-aid substance (40).
- the aperture chambers (236, 286, 426, 526), which each are at least one of the spaces, are equipped with an aperture.
- the aperture interconnects the outside of the pharmaceutical composition containers (210, 260, 400, 500) with the spaces (230, 232, 234, 236, 280, 282, 284, 286, 422, 424, 426, 520, 522, 524, 526).
- FIG. 1 is a partial cross section of the pharmaceutical composition container 10 of this embodiment.
- FIG. 2 shows how the pharmaceutical composition container 10 of this embodiment is used.
- the pharmaceutical composition container 10 of this embodiment is formed by adhering the peripheries of two synthetic-resin (preferably a soft synthetic resin that can be folded, such as low-density polyethylene) sheets 20 and 20 to each other.
- the pharmaceutical composition 10 has a swallowing-aid substance storage chamber 30, an encapsulating-item storage chamber 32 and an outlet chamber 34 formed therein.
- the swallowing-aid substance chamber 30, the encapsulating-item storage chamber 32 and the outlet chamber 34 are so formed as to maintain air tightness against the external space.
- the swallowing-aid substance storage chamber 30, the encapsulating-item storage chamber 32 and the outlet chamber 34 are arranged in one row.
- a swallowing-aid substance 40 is stored inside the swallowing-aid substance storage chamber 30.
- the swallowing-aid substance 40 in this embodiment is a sterilized jelly containing water.
- the water content of the jelly in this embodiment is set in such a manner that it is possible to provide at least two minutes of time from when the swallowing-aid substance 40 covers the surface of the encapsulating item 42, which will be explained later, until the encapsulating item 42 has completely melted.
- the outlet chamber 34 is an empty chamber until the second weak seal portion 72, which will be explained later, is broken.
- An encapsulating item 42 made of a wafer is stored inside the encapsulating-item storage chamber 32.
- a granular drug or another pharmaceutical composition 80 is stored inside the encapsulating item 42.
- the encapsulating item 42 of this embodiment is made by placing the pharmaceutical composition 80 into a commercially available wafer and twisting the portion corresponding to the inlet for the pharmaceutical composition 80. Thereby the encapsulating item 42 is tightly sealed.
- a wafer made of starch and having a thickness of 10 ⁇ m is used. This is to provide at least two minutes of time from when the swallowing-aid substance 40 covers the surface of the encapsulating item 42 until the encapsulating item 42 has completely melted.
- the thickness of the wafer should be selected as appropriate depending on the material properties thereof.
- a gas for example, nitrogen gas which does not have any effect on the pharmaceutical composition 80 or the swallowing-aid substance 40 is filled into the encapsulating-item storage chamber 32 and the swallowing-aid substance storage chamber 30.
- the portion between the swallowing-aid substance storage chamber 30 and the encapsulating-item storage chamber 32 is partitioned by a first weak seal portion 70.
- the portion between the encapsulating-item storage chamber 32 and the outlet chamber 34 is partitioned by a second weak seal portion 72.
- the first weak seal potion 70 and the second weak seal portion 72 are those parts of the portion where the two sheets 20 and 20 are adhered to each other which correspond to the portions between two adj oining spaces.
- the strength of the first weak seal portion 70 and the second weak seal portion 72 is weaker than the strength of the circumferential strong seal portion 74 (the portion where the two sheets 20 and 20 are adhered to each other excluding the first weak seal portion 70 and the second weak seal portion 72).
- the first weak seal portion 70 and the second weak seal portion 72 are easily broken by the force applied by the swallowing-aid substance 40 to the swallowing-aid substance storage chamber 30 or the encapsulating-item storage chamber 32 when the swallowing-aid substance storage chamber 30 or the encapsulating-item storage chamber 32 is pressed from the outside of the pharmaceutical composition container 10. That is to say, the swallowing-aid substance storage chamber 30 and the encapsulating-item storage chamber 32 are sealed in such a state that they can be interconnected with each other by means of force applied from the outside of pharmaceutical composition container 10.
- a pair of cutout portions 50 which each comprise a V-shaped cutout, are formed on the two sides of the outlet chamber 34.
- the predetermined aperture part 60 which is sandwiched between the cutout portions 50, is the portion where an aperture is to be formed. This aperture interconnects the inside of the outlet chamber 34 with the outside.
- the caretaker etc. presses the swallowing-aid substance storage chamber 30 from the outside of the pharmaceutical composition container 10 to break the first weak seal portion 70 by means of the pressure from inside the swallowing-aid substance storage chamber 30.
- the swallowing-aid substance 40 is pushed out into the encapsulating-item storage chamber 32.
- the swallowing-aid substance 40 that was pushed out spreads inside of the encapsulating-item storage chamber 32 and fills the surroundings of the encapsulating item 42. From this time, the surface of the encapsulating item 42 starts to melt in the swallowing-aid substance 40.
- the caretaker or patient 90 or the like squeezes the pharmaceutical composition container 10 from the swallowing-aid substance storage chamber 30 towards the encapsulating-item storage chamber 32.
- the second weak seal portion 72 breaks as a result from the pressure applied to the swallowing-aid substance 40.
- the second weak seal portion 72 is broken, the swallowing-aid substance 40 and the encapsulating item 42 are pushed out into the outlet chamber 34.
- the caretaker or patient 90 or the like apply a shearing force to the cutouts 50 to form an aperture on the outlet chamber 34.
- FIG. 2 shows the state in which the patient 90 squeezes the pharmaceutical composition container 10.
- the surface of the encapsulating item 42 has melted in the ingredients of the swallowing-aid substance 40, and therefore the surface of the encapsulating item 42 is slippery. Because the surface of the encapsulating item 42 is slippery, the encapsulating item 42 is swallowed smoothly.
- the pharmaceutical composition container 10 of this embodiment produces the following effects.
- the first effect is that it is possible to easily swallow a granular drug or another pharmaceutical composition 80.
- the second effect is that tastes such as the bitter taste of drugs are suppressed.
- the third effect is that it is possible to suppress the scattering of the pharmaceutical composition 80 in the mouth.
- the fourth effect is that concerns regarding the stability of the drug become unnecessary.
- the fifth effect is that it is possible to let patients with swallowing difficulties ingest solids of various types.
- the sixth effect is that it is possible to reduce the residual quantity of the pharmaceutical composition 80 inside the pharmaceutical composition container 10 (in this embodiment, it is possible to reduce the residual quantity close to zero).
- the encapsulating item 42 enters the mouth of the patient 90 while being covered by the swallowing-aid substance 40. At this time, the surface of encapsulating item 42 has melted.
- the encapsulating item 42 can easily be swallowed even by the patient 90, who has swallowing difficulties, because the encapsulating item 42 is enclosed in the swallowing-aid substance 40 and the surface of the encapsulating item 42 has melted. Since the pharmaceutical composition 80 is inside the encapsulating item 42, the pharmaceutical composition 80 is also swallowed with the swallowing of the encapsulating item 42. Thereby it is possible to easily swallow the pharmaceutical composition 80.
- the encapsulating item 42 enters the mouth of the patient 90 while being covered by the swallowing-aid substance 40.
- the pharmaceutical composition 80 which is contained in the encapsulating item 42, is doubly enclosed by the swallowing-aid substance 40 and the encapsulating item 42.
- the pharmaceutical composition 80 is a drug
- the probability that the tongue of the patient 90 senses the bitter taste thereof is low because the pharmaceutical composition 80 is doubly enclosed.
- the bitter taste or other tastes of the drugs are suppressed.
- the pharmaceutical composition 80 is doubly enclosed by the swallowing-aid substance 40 and the encapsulating item 42. This reduces the probability that the pharmaceutical composition 80 scatters in the mouth of the patient 90. As a result, it is possible to suppress the scattering of the pharmaceutical composition 80 in the mouth.
- Drugs are chemical substances. When chemical substances come into contact with each other, chemical reactions occur in many cases. Due to the occurrence of chemical reactions, the pharmacological effect of the drug is lost. For this reason, it is not possible to preserve a plurality of drugs in a mixed state in many cases. If the pharmaceutical compositions are to be preserved in a mixed state, it is necessary to research in advance whether the chemical substances lose their pharmacological effect.
- the pharmaceutical composition container 10 of this embodiment is equipped with a plurality of spaces. Storing one type of drug each in those spaces is substantially identical with separately preserving a plurality of drugs. This is the reason why concerns regarding the stability of the drug are unnecessary when the pharmaceutical composition container 10 of this embodiment is used. Since concerns regarding the stability of the drug are unnecessary, the advance research on whether the pharmacological effects of the plurality of drugs are lost also becomes unnecessary.
- the fifth effect will now be explained in detail.
- the activity of the pharmaceutical composition 80 per se will not have a significant effect on the difficulty or easiness of swallowing any more. Thereby it is possible to let patients with swallowing difficulties ingest solids of various types.
- the encapsulating item 42 of this embodiment is tightly sealed. Since the encapsulating item 42 is tightly sealed, the probability of the pharmaceutical composition 80 leaking from the encapsulating item 42 is extremely low. Since this probability is extremely low, it is possible to reduce the residual quantity of the pharmaceutical composition 80 inside the pharmaceutical composition container 10 (actually, it is possible to reduce the residual quantity close to zero).
- the pharmaceutical composition container 10 explained in this embodiment is presented as an example to concretize the technical concept of this invention.
- the material properties of the sheet 20 are not limited to the abovementioned embodiment.
- the shape of sheet 20, the shape of the spaces, the shape of the aperture, the dimensions, structures and positioning thereof are not limited to those mentioned in the abovementioned embodiment. It is possible to apply various changes to the pharmaceutical composition container 10 explained in this embodiment within the scope of the technical concept of this invention.
- FIG. 3 is a partial cross section of the pharmaceutical composition container 12 of the alternative embodiment 1.
- a first tapered portion 130 which faces the encapsulating-item storage chamber 110, gradually becomes narrower towards the encapsulating-item storage chamber 110.
- a second tapered portion 140 which faces the swallowing-aid substance storage chamber 100, gradually becomes narrower towards the swallowing-aid substance storage chamber 100.
- a bag-like encapsulating item 120 like that shown in FIG. 3 may also be stored.
- the encapsulating item 120 may also be stored in the pharmaceutical composition container 10 shown in FIG. 1 .
- the shape of the encapsulating item is not limited to those shown in FIG. 1 and 3 .
- a publicly known capsule may also be stored as the encapsulating item.
- the swallowing-aid substance 40 in this embodiment is a sterilized jelly containing water.
- FIG. 4 is a partial cross section of the pharmaceutical composition container 14 of the alternative embodiment 2.
- the pharmaceutical composition container 14 has a swallowing-aid substance storage chamber 102, a first encapsulating-item storage chamber 112, a second encapsulating-item storage chamber 114 and an outlet chamber 150 formed therein.
- the swallowing-aid substance storage chamber 102, the first encapsulating-item storage chamber 112, the second encapsulating-item storage chamber 114 and the outlet chamber 150 are arranged in one row.
- the end of the first encapsulating-item storage chamber 112 on the side of the second encapsulating-item storage chamber 114 becomes narrower towards the second encapsulating-item storage chamber 114, and the encapsulating item 42 is stored in the first encapsulating-item storage chamber 112; therefore it is possible to smoothly push out the encapsulating item 42 by means of the swallowing-aid substance 40.
- the end of the second encapsulating-item storage chamber 114 on the side of the outlet chamber 150 becomes narrower towards the outlet chamber 150, and the encapsulating item 42 is stored in the second encapsulating-item storage chamber 114; therefore this encapsulating item 42 is also pushed out smoothly in the same way.
- a bag-like encapsulating-item 120 like that shown in FIG. 3 may be stored in the first encapsulating-item storage chamber 112 and the second encapsulating-item storage chamber 114.
- an empty chamber may be provided between the swallowing-aid substance storage chamber and the encapsulating-item storage chamber.
- An empty chamber is a space in which nothing is stored, or in which a gas is stored that does not have any effect on the pharmaceutical composition 80 or the swallowing-aid substance 40.
- FIG. 5 is a partial cross section of the pharmaceutical composition container 15 of the alternative embodiment 3.
- an empty chamber 116 is provided as an alternative to the first encapsulating-item storage chamber 112 shown in FIG. 4 .
- Providing an empty chamber 116 can, to a certain extent, reduce the probability that the swallowing-aid substance 40 is mixed with the pharmaceutical composition 80 even if the sealing properties between the spaces are damaged due to an unintentional accident. If the pharmaceutical composition container 15 is foldable at the portion of the empty chamber 116, folding that portion can further reduce the probability that the swallowing-aid substance 40 and the pharmaceutical composition 80 are mixed.
- the pharmaceutical composition container is not limited to one made by adhering two sheets to each other.
- FIG. 6 is a partial cross section of the pharmaceutical composition container 16 of the alternative embodiment 4.
- FIG. 7 is a partial cross section of the pharmaceutical composition container 18 of the alternative embodiment 5.
- the containers are formed by double-folding one sheet.
- double-folding one sheet By forming the pharmaceutical composition containers 16 and 18 by double-folding one sheet for each, it is possible to increase the volume of the swallowing-aid substance storage chambers 104 and 106 compared to a pharmaceutical composition container formed by adhering two sheets of the same outer dimensions to each other.
- the pharmaceutical composition container may also be made by adhering the walls of one tube to each other here and there.
- the cutout portions 50 are composed of a V-shaped cutout, but the shape of the cutout in this invention may be another one than a V-shape.
- the pharmaceutical composition is a powdered or granular preparation and the swallowing-aid substance is a jelly; however, it is needless to say that the pharmaceutical composition and swallowing-aid substance applied to this invention are not limited thereto.
- the pharmaceutical composition apart from a powdered or granular preparation, the pharmaceutical composition may be a tablet, a capsule or a simple block.
- the swallowing-aid substance may be an aqueous solution, or may also be honey, custard cream, peanut spread, cheese spread or the like.
- the item formed as the pharmaceutical composition is not limited to an item that is usually treated as a medical drug.
- the item formed as the pharmaceutical composition may also be a food which is recognized for its effect of improving the health state.
- a wafer made of starch with a thickness of 10 ⁇ m as mentioned above, or a variety of other materials conventionally known as edible film materials can be used.
- the types of the materials include polysaccharides (for example, pullulan, arabinoxylan, decomposition products of guar gum, sodium alginate, carrageenan, agar-agar, pectin, cellulose etc.) and peptide-based substances (for example, gelatin, decomposition products of silk protein, decomposition products of casein etc.).
- Those materials may be used on a standalone basis or as a combination of two or more types.
- outlet chambers 34 and 150 were provided, however, it is also possible to not provide an outlet chamber 34, but to provide the cutouts 50 on the encapsulating-item storage chamber 32 or the like, open an aperture by applying shearing force to those cutouts 50 and hold that aperture against the mouth of the patient.
- the structure of the portions 70, 71 and 72 between two adjoining spaces may be different than that mentioned above.
- a thin film may be formed in the portions 70, 71 and 72 between two adjoining spaces. This kind of film can be formed by sandwiching the member that serves as the film between the two sheets 20 and 20, and adhering same to each other.
- the structure of the portions 70, 71, and 72 between two adjoining spaces must be a structure that is sealed in such a state that the spaces are interconnected by a force that is applied from the outside of the pharmaceutical composition container 10.
- This "force that is applied from the outside of the pharmaceutical composition container 10" may be a force that is directly applied to the portions 70, 71 and 72 between adjoining spaces, or may be a force that is indirectly applied to any one thereof.
- FIG. 8 is a partial cross section of the pharmaceutical composition container 11 of the alternative embodiment 6.
- the pharmaceutical composition container 11 of this embodiment has a first bag storage chamber 36, a second bag storage chamber 38, an encapsulating-item storage chamber 32 and an outlet chamber 34 formed therein. Same as the encapsulating-item storage chamber 32 and the outlet chamber 34, the first bag storage chamber 36 and the second bag storage chamber 38 are so formed as to maintain air tightness against the external space.
- the first bag storage chamber 36 and the second storage bag chamber 38 store and fix the aid-substance storage bag 22.
- the aid-substance storage bag 22 is directly fixed by the circumferential strong seal portion 74 and the third weak seal portion 76.
- the strength of the third weak seal portion 76 against breakage is roughly the same as that of the circumferential strong seal portion 74.
- a swallowing-aid substance 40 is stored inside the aid-substance storage bag 22.
- the strength of the aid-substance storage bag 22 on the end at the side facing the first weak seal portion 70 is such that the end is broken by a force applied from the outside of the pharmaceutical composition container 11.
- the swallowing-aid substance 40 is sterilized together with the aid-substance storage bag 22, then sandwiched between the sheets 20 and 20 and adhered thereto.
- the outer circumferential strong seal portion 74 etc. are formed. Thereby one end of the aid-substance storage bag 22 breaks when force is applied from the outside of the pharmaceutical composition container 11. When the end breaks, the swallowing-aid substance 40 leaks out into the first bag storage chamber 36.
- the first weak seal portion 70 is broken by the force received from the swallowing-aid substance 40.
- the encapsulating item 42 is enclosed in the swallowing-aid substance 40.
- FIG. 9 is a partial cross section of the pharmaceutical composition container 260 of this embodiment.
- the pharmaceutical composition container 260 of this embodiment is formed by double-folding one sheet made of a synthetic resin (low-density polyethylene, PET (polyethylene terephthalate) or another resin that is soft so as to be foldable and is heat-sealable, like composite resin), adhering the ends of the double-folded sheet to each other and aligning the outer shape by cutting the adhered portion.
- a synthetic resin low-density polyethylene, PET (polyethylene terephthalate) or another resin that is soft so as to be foldable and is heat-sealable, like composite resin
- the portion where the ends of the sheet are adhered to each other is the circumferential strong seal portion 270.
- the inside of the pharmaceutical composition container 260 is provided with a plurality of spaces. The portions between the plurality of spaces are sealed by a first weak seal portion 300, a second weak seal portion 302 and a third weak seal portion 304.
- the first weak seal portion 300 comprises a first weak-seal zone 310, an intermediate chamber 312 and a second weak-seal zone 314.
- One of the spaces inside the pharmaceutical composition container 260 is the swallowing-aid substance storage chamber 280.
- a swallowing-aid substance 40 is stored inside the swallowing-aid substance storage chamber 280.
- the first weak-seal zone 310 of the first weak seal portion 300 easily opens by means of the pressure received from the swallowing-aid substance 40 when force is applied to the swallowing-aid substance 40 from the outside of the pharmaceutical composition container 260.
- the first weak-seal zone 310 opens, the swallowing-aid substance 40 is pushed out into the intermediate chamber 312. Thereafter, the second weak-seal zone 314, the second weak seal portion 302 and the third weak seal portion 304 sequentially open in the same way.
- the first encapsulating-item storage chamber 282 and the second encapsulating-item storage chamber 284 exist.
- An encapsulating item 212 is stored in each of the encapsulating-item storage chambers.
- the pharmaceutical composition encapsulated by the encapsulating item 212 stored in the first encapsulating-item storage chamber 282 and the pharmaceutical composition encapsulated by the encapsulating item 212 stored in the second encapsulating-item storage chamber 284 are of different types.
- one of the spaces inside the pharmaceutical composition container 260 is an aperture chamber 286.
- the aperture chamber 286 is provided on one end of the pharmaceutical composition container 260 and serves as the chute (in other words, the device for dropping the encapsulating item 212 into the mouth of the patient) for the ingestion of the encapsulating item 212.
- the cover 288 Of the two ends of the pharmaceutical composition container 260, the end on the opposite side of the end on which the aperture chamber 286 is provided, is the cover 288.
- the boundary between the swallowing-aid substance storage chamber 280 and the cover 288 is the bottom strong seal portion 272.
- the strength of the bottom strong seal portion 272 is the same as that of the circumferential strong seal portion 270; therefore the bottom strong seal portion 272 is not broken even when force is applied to the swallowing-aid substance 40 from the outside of the pharmaceutical composition container 260.
- the portion which is more to the side of the second encapsulating-item storage chamber 284 than the cover 288 is referred to as the "container body.”
- FIG. 10 is an external view of the portion of the pharmaceutical composition container 260 of this embodiment which corresponds to the rear surface when viewed as shown in FIG. 9 .
- a label 262 is adhered to the pharmaceutical composition container 260 of this embodiment.
- the features unique to the pharmaceutical composition container 260 of this embodiment as compared to the pharmaceutical composition containers of the other embodiments are that: the cover 288 is disposed on one end and a cover insert portion 320 which is inserted into this cover 288 is disposed on the other end; the width of the pharmaceutical composition container 260 is larger on the base 330 of the portion which is inserted into the cover 238; the bottom strong seal portion 272 and a portion of the second weak seal portion 302 or a portion of the third weak seal portion 304 are folded over to insert the tip of the cover insert portion 320 into the cover 238, and the base 330 is on the outside of the cover 238.
- FIG. 11 shows the state where the cover insert portion 320 is inserted into the cover 238 and the base 330 is on the outside of the cover 238.
- the portion of the base 330 is depressed; therefore it is possible to easily to pull out the cover insert portion 320 by inserting a finger thereinto.
- FIG. 12 is a view of the portion which corresponds to the rear surface when viewed as shown in FIG. 11 , in the state shown in FIG. 11 .
- the major part of the rear surface of the pharmaceutical composition container 260 is occupied by the label 262.
- a finger is engaged with the abovementioned base 330 and the abovementioned cover insert portion 320 is pulled out of the cover 238 in this state.
- the cover insert portion 320 is pulled out, the cover insert portion 320 is placed into the mouth of the patient.
- the subsequent usage method is the same as in the other embodiments or alternative embodiments thereof.
- the cover insert portion 320 can easily be pulled out because a finger can be engaged with the base 330 of the cover insert portion 320.
- composition container 260 of this embodiment produces the same effects like that of the embodiment 1.
- FIG. 13 is a partial cross section of the pharmaceutical composition container 400 of this embodiment.
- the pharmaceutical composition container 400 of this embodiment is formed by double-folding one sheet made of a synthetic resin, adhering the ends of the double-folded sheet to each other and aligning the outer shape by cutting the adhered portion.
- the portion where the ends of the sheet are adhered to each other is the circumferential strong seal portion 410.
- the inside of the pharmaceutical composition container 400 is provided with a plurality of spaces. The portions between the plurality of spaces are sealed by a first weak seal portion 440, a second weak seal portion 442 and a third weak seal portion 444.
- the first weak seal portion 440 comprises a first weak-seal zone 450, an intermediate chamber 452 and a second weak-seal zone 454.
- One of the spaces is the swallowing-aid substance storage chamber 420.
- a swallowing-aid substance 40 is stored inside the swallowing-aid substance storage chamber 420.
- the first weak seal zone 450 and the second weak seal zone 454 sequentially open in the same way as the first weak seal portion 300, the second weak seal portion 302 and the third weak seal portion 304 in the embodiment 2.
- the reason why the first weak seal zone 450 and the second weak seal zone 454 open in this way is the same as that in the embodiment 2.
- the first encapsulating-item storage chamber 422 and the second encapsulating-item storage chamber 424 exist.
- An encapsulating item 212 is stored in each of the encapsulating-item storage chambers.
- the pharmaceutical composition encapsulated by the encapsulating item 212 stored in the first encapsulating-item storage chamber 422 and the pharmaceutical composition encapsulated by the encapsulating item 212 stored in the second encapsulating-item storage chamber 424 are of different types.
- One of the spaces is an aperture chamber 426.
- the aperture chamber 426 serves as a chute for the ingestion of the encapsulating item 212.
- the cover 428 Of the two ends of the pharmaceutical composition container 400, the end on the opposite side of the end on which the aperture chamber 426 is provided, is the cover 428.
- the boundary between the swallowing-aid substance storage chamber 420 and the cover 478 is the bottom strong seal portion 412.
- the strength of the bottom strong seal portion 412 is the same as that of the circumferential strong seal portion 410; therefore the bottom strong seal portion 412 is not broken even when force is applied to the swallowing-aid substance 40 from the outside of the pharmaceutical composition container 400.
- the cover 478 is disposed on one end; the bottom strong seal portion 412 and the base of the portion where the aperture chamber 426 is disposed are folded over to insert the portion where the aperture chamber 426 is disposed into the cover 478; the tip 480 of the portion where the aperture chamber 426 is disposed is round; and a part of the edge 482 of the cover 478 is cut out.
- the portion which is more to the side of the second encapsulating-item storage chamber 424 than the cover 478 is referred to as the "container body.”
- the one of the two ends of the pharmaceutical composition container 400 on which the aperture chamber 426 is disposed is pulled out of the cover 478.
- the subsequent usage method is the same as in the other embodiments.
- FIG. 14 shows the state in which pharmaceutical composition container 400 is folded over during production. After the pharmaceutical composition container 400 is folded over, the portion where the aperture chamber 426 is disposed is inserted into the cover 478. At this time, the tip 480 of the portion where the aperture chamber 426 is disposed gets caught at any position of the cut-out edge 482 of the cover 478 and opens the mouth of the cover 478. Since the mouth of the cover 478 is opened, the tip 480 smoothly enters the inside of the cover 478.
- FIG. 15 shows the pharmaceutical composition container 400 after the portion where the aperture chamber 426 is disposed is inserted into the cover 478.
- composition container 400 of this embodiment produces the same effects like that of the embodiment 1.
- FIG. 16 is a partial cross section of the pharmaceutical composition container 500 of this embodiment.
- the pharmaceutical composition container 500 of this embodiment is formed by double-folding one sheet made of a synthetic resin, adhering the ends of the double-folded sheet to each other and aligning the outer shape by cutting the adhered portion.
- the portion where the ends of the sheet are adhered to each other is the circumferential strong seal portion 510.
- the inside of the pharmaceutical composition container 500 is provided with a plurality of spaces. The portions between the plurality of spaces are sealed by a first weak seal portion 540, a second weak seal portion 542 and a third weak seal portion 544.
- the first weak seal portion 540 comprises a first weak-seal zone 550, an intermediate chamber 552 and a second weak-seal zone 554.
- One of the spaces inside the pharmaceutical composition container 500 is the swallowing-aid substance storage chamber 520.
- a swallowing-aid substance 40 is stored inside the swallowing-aid substance storage chamber 520.
- the first weak seal zone 550 and the second weak seal zone 554 sequentially open in the same way as the first weak seal portion 300, the second weak seal portion 302 and the third weak seal portion 304 in the embodiment 2.
- the reason why the first weak seal zone 550 and the second weak seal zone 554 open in this way is the same as that in the embodiment 2.
- the first encapsulating-item storage chamber 522 and the second encapsulating-item storage chamber 524 exist.
- An encapsulating item 212 is stored in each of the encapsulating-item storage chambers.
- the pharmaceutical composition encapsulated by the encapsulating item 212 stored in the first encapsulating-item storage chamber 522 and the pharmaceutical composition encapsulated by the encapsulating item 212 stored in the second encapsulating-item storage chamber 524 are of different types.
- One of the spaces is an aperture chamber 526.
- the aperture chamber 526 serves as a chute for the ingestion of the encapsulating item 212.
- the cover 528 Of the two ends of the pharmaceutical composition container 500, the end on the opposite side of the end on which the aperture chamber 526 is provided, is the cover 528.
- the boundary between the swallowing-aid substance storage chamber 520 and the cover 528 is the bottom strong seal portion 512.
- the strength of the bottom strong seal portion 512 is the same as that of the circumferential strong seal portion 510; therefore the bottom strong seal portion 512 is not broken even when force is applied to the swallowing-aid substance 40 from the outside of the pharmaceutical composition container 500.
- the portion which is more to the side of the second encapsulating-item storage chamber 524 than the cover 528 is referred to as the "container body.”
- FIG. 17 is a partial cross section showing one end of the pharmaceutical composition container 500 during the production thereof.
- FIG. 18 is a perspective view showing one end of the pharmaceutical composition container 500 during the production thereof.
- the features unique to the pharmaceutical composition container 500 of this embodiment as compared to the pharmaceutical composition containers of the other embodiments will be explained while referring to FIG. 17 and FIG. 18 .
- the features thereof are that: the bottom strong seal portion 512 and the base of the portion where the aperture chamber 526 is disposed are folded over to insert the portion where the aperture chamber 526 is disposed into the cover 528; and a melt-bonding margin 514 is disposed on the tip portion 516 which is inserted into the cover 528 on the circumferential strong seal portion 510. This melt-bonding margin 514 is folded back like shown in FIG. 18 and melt-bonded to the tip portion 516.
- the usage method of the pharmaceutical composition container 500 of this embodiment is the same as that of the embodiment 3.
- composition container 500 of this embodiment produces the same effects like that of the embodiment 1.
- FIG. 19 is a partial cross section of the pharmaceutical composition container 210 of this embodiment.
- the pharmaceutical composition container 210 of this embodiment is formed by double-folding one sheet made of a synthetic resin, adhering the ends of the double-folded sheet to each other and aligning the outer shape by cutting the adhered portion.
- the portions where the ends of the sheet are adhered to each other are the circumferential strong seal portions 220 and 222.
- the inside of the pharmaceutical composition container 210 is provided with a plurality of spaces.
- the portions between the plurality of spaces are sealed by a first weak seal portion 240, a second weak seal portion 242 and a third weak seal portion 244.
- the first weak seal portion 240 comprises a first weak-seal zone 250, an intermediate chamber 252 and a second weak-seal zone 254.
- One of the spaces inside the pharmaceutical composition container 210 is the swallowing-aid substance storage chamber 230.
- a swallowing-aid substance 40 is stored inside the swallowing-aid substance storage chamber 230.
- the first weak seal zone 250 and the second weak seal zone 254 sequentially open in the same way as the first weak seal portion 300, the second weak seal portion 302 and the third weak seal portion 304 in the embodiment 2.
- the reason why the first weak seal zone 250 and the second weak seal zone 254 open in this way is the same as that in the embodiment 2.
- the first encapsulating-item storage chamber 232 and the second encapsulating-item storage chamber 234 exist.
- An encapsulating item 212 is stored in each of the encapsulating-item storage chambers.
- the pharmaceutical composition encapsulated by the encapsulating item 212 stored in the first encapsulating-item storage chamber 232 and the pharmaceutical composition encapsulated by the encapsulating item 212 stored in the second encapsulating-item storage chamber 234 are of different types. Further, the outer shape of the encapsulating items 212 is different from that of the encapsulating item 42 in the embodiment 1.
- one of the spaces inside the pharmaceutical composition container 210 is an aperture chamber 236.
- the aperture chamber 236 serves as a chute for the ingestion of the encapsulating item 212.
- the pharmaceutical composition 210 of this embodiment is wound in such a manner that the swallowing-aid substance storage chamber 230 surrounds the aperture chamber 236. If the pharmaceutical composition container 210 is only wound, it is likely that the pharmaceutical composition container 210 straightens during the time from the completion until the use of the pharmaceutical composition container 210; therefore end of the swallowing-aid substance storage chamber 230 of the wound pharmaceutical composition container 210 is fixed with a tape 214.
- FIG. 20 shows the wound pharmaceutical composition container 210.
- the tape 214 is peeled off and the pharmaceutical composition container 210 is straightened.
- the aperture chamber 236 is placed into the mouth of the patient. Thereafter the encapsulating item 212 is ingested in the same way as the embodiment 1 or the alternative embodiments thereof.
- the pharmaceutical composition container 210 of this embodiment produces the same effects like that of the embodiment 1.
- the pharmaceutical composition container of this invention is suitable for the use as, for example, a container for the ingestion of a drug.
- the pharmaceutical composition container of this invention is suitable for the use as a container for the ingestion of a drug, wherein the drug is filled into the container by a system as mentioned below.
- a system is one wherein a plurality of auger filling machines are set up, a transport system and weighing system are added, the filling machines, the transport system and the weighing system are connected to a medical-drug production line and automatic operation is performed over a long time.
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Abstract
Description
- This invention relates to a pharmaceutical composition container; more specifically, to a pharmaceutical composition container so configured as to allow the reduction of the residual quantity of the pharmaceutical composition.
- In general, when ingesting a pharmaceutical composition like a powdered or granular preparation, the pharmaceutical composition is swallowed using water. However, since this pharmaceutical composition is swallowed by drinking water after having the pharmaceutical composition received on the tongue, there are problems such as that a part of the pharmaceutical composition stays inside the mouth for a long time, that there is irritation from the pharmaceutical ingredients, or that it is not possible to ingest the pharmaceutical composition while lying down, since the pharmaceutical composition is ingested with water, which is highly fluid.
- Patent document 1 discloses a multi-chamber container. This multi-chamber container is so partitioned into a plurality of spaces as to enable the spaces to be interconnected with each other. The spaces are sealed in such a state that they can be interconnected with each other by means of force applied from the outside. A granular agent is stored in a tightly sealed state in any of the spaces. A thick fluid substance is stored in a tightly sealed state in one or more other spaces. After interconnecting the spaces with each other and gathering and mixing the granular agent with the thick fluid substance, it is possible to take out the mixture from a take-out port provided on any of the spaces.
- According to the container disclosed in patent document 1, it is possible to ingest a granular agent by means of an extremely simple operation. Moreover, according to the multi-chamber container disclosed in patent document 1, it is possible to significantly reduce the resistance of the patient towards taking the medication.
-
- Patent document 1: Japanese Patent Laid-Open No.
10-234820 - However, with the invention disclosed in patent document 1, there is the problem that, when the pharmaceutical composition is a powder, a powdered preparation or a granular preparation, it is highly probable that there are residues in the multi-chamber container.
- The technical issue addressed by this invention was drafted to solve the abovementioned problem, and the purpose of the invention is to provide a pharmaceutical composition container that allows the reduction of the residual quantity of the pharmaceutical composition.
- The pharmaceutical composition container of this invention is explained in reference to the drawings. Note that the use of the reference numerals of the drawings in this column is intended to facilitate the understanding of the content of the invention and is not intended to limit the content to the scope indicated.
- According to the aspects of this invention in order to achieve the abovementioned purpose, the pharmaceutical composition containers (10, 11, 12, 14, 15, 16, 18) are equipped with a plurality of spaces (30, 32, 34, 36, 38, 100, 102, 104, 106, 110, 112, 114, 116, 150). The portions (70, 72, 76) between two adjoining spaces are sealed. The portions (70, 72, 76) between two adjoining spaces open when force is applied from the outside of the pharmaceutical composition containers (10, 11, 12, 14, 15, 16, 18). A swallowing-aid substance (40) is stored in swallowing-aid substance storing chambers (30, 100, 102, 104, 106) which are at least one of the spaces. Encapsulating items (42, 120) are stored in encapsulating-item storing chambers (32, 110, 112, 114) which each are at least one of the spaces. The encapsulating items (42, 120) contain the pharmaceutical composition (80) . At least the surface of the encapsulating items (42, 120) melts in the ingredients of the swallowing-aid substance (40). The pharmaceutical composition containers (10, 11, 12, 14, 15, 16, 18) are provided with a predetermined aperture part (60) . The predetermined aperture part (60) is a portion where an aperture is to be formed. The aperture interconnects the outside of the pharmaceutical composition containers (10, 11, 12, 14, 15, 16, 18) with the spaces (30, 32, 34, 36, 38, 100, 102, 104, 106, 110, 112, 114, 116, 150).
- The portions (70, 71, 72, 76) between two adjoining spaces are sealed. The portions (70, 71, 72, 76) between two adjoining spaces open when force is applied from the outside of the pharmaceutical composition containers (10, 11, 12, 14, 15, 16, 18) . By the opening of the portions (70, 71, 72, 76) between two adjoining spaces, it is possible to guide the swallowing-aid substance (40) from the swallowing-aid substance storage chambers (30, 100, 102, 104, 106) to the encapsulating-item storage chambers (32, 110, 112, 114) . Thereby, when holding, after the aperture is formed on the predetermined aperture part (60), that aperture against the mouth of a person with swallowing difficulties and pushing out the swallowing-aid substance (40) and the encapsulating items (42, 120) from that aperture, the encapsulating items (42, 120) will enter the mouth of the person with swallowing difficulties while being enclosed in swallowing-aid substance (40). The encapsulating items (42, 120) are swallowed. Since the pharmaceutical composition (80) is inside the encapsulating items (42, 120), the pharmaceutical composition (80) inside the encapsulating items (42, 120) is pushed out at the same time when the encapsulating items (42, 120) are pushed out. As a result, the residual quantity of the pharmaceutical composition (80) in the encapsulating-item storage chambers (32, 110, 112, 114) is reduced as compared to the case where the pharmaceutical composition is not inside the encapsulating items (42, 120) . When at least the surface of the encapsulating items (42, 120) melts in the ingredients of the swallowing-aid substance (40), the surface of the encapsulating items (42, 120) will melt after the swallowing-aid substance (40) is guided into the encapsulating-item storage chambers (32, 110, 112, 114). The encapsulating items (42, 120) can easily be swallowed even by a person with swallowing difficulties because the encapsulating items (42, 120) are enclosed in the swallowing-aid substance (40) and the surface of encapsulating items (42, 120) has melted. That being the case, the pharmaceutical composition (80) is also swallowed with the swallowing of the encapsulating items (42, 120).
- Further, it is preferable that the abovementioned swallowing-aid substance (40) contain water. In this case, the material of the encapsulating items (42, 120) is a water-soluble substance. This reduces the probability that swallowing becomes difficult because the surfaces of the encapsulating items (42, 120) have not sufficiently melted.
- Or, it is preferable that the abovementioned swallowing-aid substance (40) be a water-containing jelly. In this case, it is preferable that the water-soluble substance be starch.
- Moreover, it is preferable that a chamber (116), which is at least one of the abovementioned spaces, is disposed between the swallowing-aid substance storage chamber (102) and the encapsulating-item storage chamber (114). This is because the provision of a chamber (116) reduces the probability that the swallowing-aid substance (40) comes into contact with the encapsulating item (42) when the two adjoining spaces (102, 114) are interconnected against the will of the user or handler of the pharmaceutical composition container (15). Reducing that probability also lowers the probability that the encapsulating item (42) melts before the ingestion of the pharmaceutical composition (80). As a result, the pharmaceutical composition container (15) will be easy to preserve and easy to handle.
- Further, it is preferable that the abovementioned encapsulating item (42) be tightly sealed. Note that "tightly sealed" in this description means being sealed in such a manner that no gaps exist.
- According to the aspects of this invention, the pharmaceutical composition containers (210, 260, 400, 500) are equipped with at least three spaces (230, 232, 234, 236, 280, 282, 284, 286, 422, 424, 426, 520, 522, 524, 526). The portions (240, 242, 244, 300, 302, 304, 440, 442, 444, 540, 542, 544) between two adjoining spaces are sealed. The portions (240, 242, 244, 300, 302, 304, 440, 442, 444, 540, 542, 544) between two adjoining spaces open when force is applied from the outside of the pharmaceutical composition containers (210, 260, 400, 500). A swallowing-aid substance (40) is stored in swallowing-aid substance storage chambers (230, 280, 520) which each are at least one of the spaces. An encapsulating item (212) is stored in encapsulating-item storage chambers (232, 234, 282, 284, 422, 424, 522, 524) which each are at least one of the spaces. The encapsulating item (212) contains the pharmaceutical composition (80). At least the surface of the encapsulating item (212) melts in the ingredients of the swallowing-aid substance (40). The aperture chambers (236, 286, 426, 526), which each are at least one of the spaces, are equipped with an aperture. The aperture interconnects the outside of the pharmaceutical composition containers (210, 260, 400, 500) with the spaces (230, 232, 234, 236, 280, 282, 284, 286, 422, 424, 426, 520, 522, 524, 526).
- According to this invention, it is possible to reduce the residual quantity of a pharmaceutical composition.
-
-
FIG. 1 is a partial cross section of the pharmaceutical composition container of the embodiment 1 of this invention. -
FIG. 2 shows how the pharmaceutical composition container of the embodiment 1 of this invention is used. -
FIG. 3 is a partial cross section of the pharmaceutical composition container of the alternative embodiment 1 of this invention. -
FIG. 4 is a partial cross section of the pharmaceutical composition container of the alternative embodiment 2 of this invention. -
FIG. 5 is a partial cross section of the pharmaceutical composition container of the alternative embodiment 3 of this invention. -
FIG. 6 is a partial cross section of the pharmaceutical composition container of the alternative embodiment 4 of this invention. -
FIG. 7 is a partial cross section of the pharmaceutical composition container of the alternative embodiment 5 of this invention. -
FIG. 8 is a partial cross section of the pharmaceutical composition container of the alternative embodiment 6 of this invention. -
FIG. 9 is a partial cross section of the pharmaceutical composition container of the embodiment 2 of this invention. -
FIG. 10 is an external view of the pharmaceutical composition container of the embodiment 2 of this invention. -
FIG. 11 shows a state of the embodiment 2 of this invention wherein the cover insert portion is inserted into the cover and the base is on the outside of the cover. -
FIG. 12 is a rear view of the state in the embodiment 2 of this invention wherein the cover insert portion is inserted into the cover. -
FIG. 13 is a partial cross section of the pharmaceutical composition container of the embodiment 3 of this invention. -
FIG. 14 shows the state of the embodiment 3 of this invention wherein the pharmaceutical composition container is folded. -
FIG. 15 shows the state of the embodiment 3 of this invention after one end of the pharmaceutical composition container is inserted into the cover. -
FIG. 16 is a partial cross section of the pharmaceutical composition container of the embodiment 4 of this invention. -
FIG. 17 is a partial cross section showing one end of the pharmaceutical composition container of the embodiment 4 of this invention during the production thereof. -
FIG. 18 is a perspective view showing one end of the pharmaceutical composition container of the embodiment 4 of this invention during the production thereof. -
FIG. 19 is a partial cross section of the pharmaceutical composition container of the embodiment 5 of this invention. -
FIG. 20 shows the wound state of the pharmaceutical composition container of the embodiment 5 of this invention. - The following explains the embodiments of this invention on the basis of the drawings. In the following explanations, identical parts are assigned the same reference numeral. The names and functions thereof are also the same. Accordingly, detailed explanations thereof will not be repeated.
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FIG. 1 is a partial cross section of thepharmaceutical composition container 10 of this embodiment.FIG. 2 shows how thepharmaceutical composition container 10 of this embodiment is used. - The
pharmaceutical composition container 10 of this embodiment is formed by adhering the peripheries of two synthetic-resin (preferably a soft synthetic resin that can be folded, such as low-density polyethylene)sheets pharmaceutical composition 10 has a swallowing-aidsubstance storage chamber 30, an encapsulating-item storage chamber 32 and anoutlet chamber 34 formed therein. The swallowing-aid substance chamber 30, the encapsulating-item storage chamber 32 and theoutlet chamber 34 are so formed as to maintain air tightness against the external space. The swallowing-aidsubstance storage chamber 30, the encapsulating-item storage chamber 32 and theoutlet chamber 34 are arranged in one row. - A swallowing-
aid substance 40 is stored inside the swallowing-aidsubstance storage chamber 30. The swallowing-aid substance 40 in this embodiment is a sterilized jelly containing water. The water content of the jelly in this embodiment is set in such a manner that it is possible to provide at least two minutes of time from when the swallowing-aid substance 40 covers the surface of the encapsulatingitem 42, which will be explained later, until the encapsulatingitem 42 has completely melted. Theoutlet chamber 34 is an empty chamber until the secondweak seal portion 72, which will be explained later, is broken. - An encapsulating
item 42 made of a wafer is stored inside the encapsulating-item storage chamber 32. A granular drug or anotherpharmaceutical composition 80 is stored inside the encapsulatingitem 42. The encapsulatingitem 42 of this embodiment is made by placing thepharmaceutical composition 80 into a commercially available wafer and twisting the portion corresponding to the inlet for thepharmaceutical composition 80. Thereby the encapsulatingitem 42 is tightly sealed. However, in this embodiment, a wafer made of starch and having a thickness of 10 µm is used. This is to provide at least two minutes of time from when the swallowing-aid substance 40 covers the surface of the encapsulatingitem 42 until the encapsulatingitem 42 has completely melted. Naturally, the thickness of the wafer should be selected as appropriate depending on the material properties thereof. - Note that, if necessary, a gas (for example, nitrogen gas) which does not have any effect on the
pharmaceutical composition 80 or the swallowing-aid substance 40 is filled into the encapsulating-item storage chamber 32 and the swallowing-aidsubstance storage chamber 30. - The portion between the swallowing-aid
substance storage chamber 30 and the encapsulating-item storage chamber 32 is partitioned by a firstweak seal portion 70. The portion between the encapsulating-item storage chamber 32 and theoutlet chamber 34 is partitioned by a secondweak seal portion 72. The firstweak seal potion 70 and the secondweak seal portion 72 are those parts of the portion where the twosheets weak seal portion 70 and the secondweak seal portion 72 is weaker than the strength of the circumferential strong seal portion 74 (the portion where the twosheets weak seal portion 70 and the second weak seal portion 72). This is made possible by using different materials as the adhesive agents to adhere the twosheets weak seal portion 70 and the secondweak seal portion 72 are easily broken by the force applied by the swallowing-aid substance 40 to the swallowing-aidsubstance storage chamber 30 or the encapsulating-item storage chamber 32 when the swallowing-aidsubstance storage chamber 30 or the encapsulating-item storage chamber 32 is pressed from the outside of thepharmaceutical composition container 10. That is to say, the swallowing-aidsubstance storage chamber 30 and the encapsulating-item storage chamber 32 are sealed in such a state that they can be interconnected with each other by means of force applied from the outside ofpharmaceutical composition container 10. - A pair of
cutout portions 50, which each comprise a V-shaped cutout, are formed on the two sides of theoutlet chamber 34. Thepredetermined aperture part 60, which is sandwiched between thecutout portions 50, is the portion where an aperture is to be formed. This aperture interconnects the inside of theoutlet chamber 34 with the outside. - The procedure for taking the
pharmaceutical composition 80 out of thepharmaceutical composition container 10 and ingesting thepharmaceutical composition 80 will be explained while referring toFIG. 2 . - First, the caretaker etc. presses the swallowing-aid
substance storage chamber 30 from the outside of thepharmaceutical composition container 10 to break the firstweak seal portion 70 by means of the pressure from inside the swallowing-aidsubstance storage chamber 30. When the firstweak seal portion 70 is broken, the swallowing-aid substance 40 is pushed out into the encapsulating-item storage chamber 32. The swallowing-aid substance 40 that was pushed out spreads inside of the encapsulating-item storage chamber 32 and fills the surroundings of the encapsulatingitem 42. From this time, the surface of the encapsulatingitem 42 starts to melt in the swallowing-aid substance 40. - After the swallowing-
aid substance 40 is pushed out into the encapsulating-item storage chamber 32, the caretaker orpatient 90 or the like squeezes thepharmaceutical composition container 10 from the swallowing-aidsubstance storage chamber 30 towards the encapsulating-item storage chamber 32. Thereby, the secondweak seal portion 72 breaks as a result from the pressure applied to the swallowing-aid substance 40. When the secondweak seal portion 72 is broken, the swallowing-aid substance 40 and the encapsulatingitem 42 are pushed out into theoutlet chamber 34. When the swallowing-aid substance 40 and the encapsulatingitem 42 are pushed out into theoutlet chamber 34, the caretaker orpatient 90 or the like apply a shearing force to thecutouts 50 to form an aperture on theoutlet chamber 34. When the aperture is formed, the caretaker orpatient 90 or the like hold that aperture against the mouth of the patient and squeeze thepharmaceutical composition container 10 from the swallowing-aidsubstance storage chamber 30 towards the encapsulating-item storage chamber 32. Thereby the encapsulatingitem 42, which is covered by the swallowing-aid substance 40, enters the mouth of thepatient 90.FIG. 2 shows the state in which thepatient 90 squeezes thepharmaceutical composition container 10. At this time, the surface of the encapsulatingitem 42 has melted in the ingredients of the swallowing-aid substance 40, and therefore the surface of the encapsulatingitem 42 is slippery. Because the surface of the encapsulatingitem 42 is slippery, the encapsulatingitem 42 is swallowed smoothly. - In this way, the
pharmaceutical composition container 10 of this embodiment produces the following effects. The first effect is that it is possible to easily swallow a granular drug or anotherpharmaceutical composition 80. The second effect is that tastes such as the bitter taste of drugs are suppressed. The third effect is that it is possible to suppress the scattering of thepharmaceutical composition 80 in the mouth. The fourth effect is that concerns regarding the stability of the drug become unnecessary. The fifth effect is that it is possible to let patients with swallowing difficulties ingest solids of various types. The sixth effect is that it is possible to reduce the residual quantity of thepharmaceutical composition 80 inside the pharmaceutical composition container 10 (in this embodiment, it is possible to reduce the residual quantity close to zero). - The first effect will now be explained in detail. The encapsulating
item 42 enters the mouth of the patient 90 while being covered by the swallowing-aid substance 40. At this time, the surface of encapsulatingitem 42 has melted. The encapsulatingitem 42 can easily be swallowed even by thepatient 90, who has swallowing difficulties, because the encapsulatingitem 42 is enclosed in the swallowing-aid substance 40 and the surface of the encapsulatingitem 42 has melted. Since thepharmaceutical composition 80 is inside the encapsulatingitem 42, thepharmaceutical composition 80 is also swallowed with the swallowing of the encapsulatingitem 42. Thereby it is possible to easily swallow thepharmaceutical composition 80. - The second effect will now be explained in detail. As mentioned above, the encapsulating
item 42 enters the mouth of the patient 90 while being covered by the swallowing-aid substance 40. Thereby thepharmaceutical composition 80, which is contained in the encapsulatingitem 42, is doubly enclosed by the swallowing-aid substance 40 and the encapsulatingitem 42. Even if thepharmaceutical composition 80 is a drug, the probability that the tongue of the patient 90 senses the bitter taste thereof is low because thepharmaceutical composition 80 is doubly enclosed. As a result, the bitter taste or other tastes of the drugs are suppressed. - The third effect will now be explained in detail. As mentioned above, the
pharmaceutical composition 80 is doubly enclosed by the swallowing-aid substance 40 and the encapsulatingitem 42. This reduces the probability that thepharmaceutical composition 80 scatters in the mouth of thepatient 90. As a result, it is possible to suppress the scattering of thepharmaceutical composition 80 in the mouth. - The fourth effect will now be explained in detail. Drugs are chemical substances. When chemical substances come into contact with each other, chemical reactions occur in many cases. Due to the occurrence of chemical reactions, the pharmacological effect of the drug is lost. For this reason, it is not possible to preserve a plurality of drugs in a mixed state in many cases. If the pharmaceutical compositions are to be preserved in a mixed state, it is necessary to research in advance whether the chemical substances lose their pharmacological effect. The
pharmaceutical composition container 10 of this embodiment is equipped with a plurality of spaces. Storing one type of drug each in those spaces is substantially identical with separately preserving a plurality of drugs. This is the reason why concerns regarding the stability of the drug are unnecessary when thepharmaceutical composition container 10 of this embodiment is used. Since concerns regarding the stability of the drug are unnecessary, the advance research on whether the pharmacological effects of the plurality of drugs are lost also becomes unnecessary. - The fifth effect will now be explained in detail. As the swallowing-
aid substance 40 and the encapsulatingitem 42 are swallowed after the swallowing-aid substance 40 is guided into the encapsulating-item storage chamber 32, the activity of thepharmaceutical composition 80 per se will not have a significant effect on the difficulty or easiness of swallowing any more. Thereby it is possible to let patients with swallowing difficulties ingest solids of various types. - The sixth effect will now be explained in detail. When the swallowing-
aid substance 40 and the encapsulatingitem 42 are pushed out from the aperture formed on thepharmaceutical composition container 10, thepharmaceutical composition 80 inside the encapsulatingitem 42 will also be pushed out at the same time. This significantly reduces the residual quantity of thepharmaceutical composition 80 in the encapsulating-item storage chamber 32 as compared to cases where thepharmaceutical composition 80 is not contained in the encapsulatingitem 42. Moreover, the encapsulatingitem 42 of this embodiment is tightly sealed. Since the encapsulatingitem 42 is tightly sealed, the probability of thepharmaceutical composition 80 leaking from the encapsulatingitem 42 is extremely low. Since this probability is extremely low, it is possible to reduce the residual quantity of thepharmaceutical composition 80 inside the pharmaceutical composition container 10 (actually, it is possible to reduce the residual quantity close to zero). - The
pharmaceutical composition container 10 explained in this embodiment is presented as an example to concretize the technical concept of this invention. The material properties of thesheet 20 are not limited to the abovementioned embodiment. The shape ofsheet 20, the shape of the spaces, the shape of the aperture, the dimensions, structures and positioning thereof are not limited to those mentioned in the abovementioned embodiment. It is possible to apply various changes to thepharmaceutical composition container 10 explained in this embodiment within the scope of the technical concept of this invention. - For example,
FIG. 3 is a partial cross section of thepharmaceutical composition container 12 of the alternative embodiment 1. On the swallowing-aidsubstance storage chamber 100 in thispharmaceutical composition container 12, a firsttapered portion 130, which faces the encapsulating-item storage chamber 110, gradually becomes narrower towards the encapsulating-item storage chamber 110. On the encapsulating-item storage chamber 110, a secondtapered portion 140, which faces the swallowing-aidsubstance storage chamber 100, gradually becomes narrower towards the swallowing-aidsubstance storage chamber 100. This increases the probability that, when the firstweak seal portion 70 is broken and the swallowing-aid substance 40 is pushed out into the encapsulating-item storage chamber 110, the entire quantity of the swallowing-aid substance 40 is pushed out. - Further, as an alternative to an encapsulating
item 42 like that shown inFIG. 1 , a bag-like encapsulating item 120 like that shown inFIG. 3 may also be stored. Of course, the encapsulatingitem 120 may also be stored in thepharmaceutical composition container 10 shown inFIG. 1 . Moreover, the shape of the encapsulating item is not limited to those shown inFIG. 1 and3 . For example, as an alternative to the encapsulatingitems aid substance 40 in this embodiment is a sterilized jelly containing water. For this reason, if a publicly known capsule is stored as the encapsulating item, the surface of that capsule melts in water, which is an ingredient of the swallowing-aid substance 40. Thereafter the capsule melts in the digestive juices of the stomach or intestines. - Further, the number of spaces provided in one pharmaceutical composition container may be only two, or may be three or more.
FIG. 4 is a partial cross section of thepharmaceutical composition container 14 of the alternative embodiment 2. Thepharmaceutical composition container 14 has a swallowing-aidsubstance storage chamber 102, a first encapsulating-item storage chamber 112, a second encapsulating-item storage chamber 114 and anoutlet chamber 150 formed therein. The swallowing-aidsubstance storage chamber 102, the first encapsulating-item storage chamber 112, the second encapsulating-item storage chamber 114 and theoutlet chamber 150 are arranged in one row. Note that the end of the first encapsulating-item storage chamber 112 on the side of the second encapsulating-item storage chamber 114 becomes narrower towards the second encapsulating-item storage chamber 114, and the encapsulatingitem 42 is stored in the first encapsulating-item storage chamber 112; therefore it is possible to smoothly push out the encapsulatingitem 42 by means of the swallowing-aid substance 40. The end of the second encapsulating-item storage chamber 114 on the side of theoutlet chamber 150 becomes narrower towards theoutlet chamber 150, and the encapsulatingitem 42 is stored in the second encapsulating-item storage chamber 114; therefore this encapsulatingitem 42 is also pushed out smoothly in the same way. On a side note, as an alternative to the encapsulatingitem 42, a bag-like encapsulating-item 120 like that shown inFIG. 3 may be stored in the first encapsulating-item storage chamber 112 and the second encapsulating-item storage chamber 114. - Moreover, an empty chamber may be provided between the swallowing-aid substance storage chamber and the encapsulating-item storage chamber. An empty chamber is a space in which nothing is stored, or in which a gas is stored that does not have any effect on the
pharmaceutical composition 80 or the swallowing-aid substance 40.FIG. 5 is a partial cross section of thepharmaceutical composition container 15 of the alternative embodiment 3. As an alternative to the first encapsulating-item storage chamber 112 shown inFIG. 4 , anempty chamber 116 is provided. Providing anempty chamber 116 can, to a certain extent, reduce the probability that the swallowing-aid substance 40 is mixed with thepharmaceutical composition 80 even if the sealing properties between the spaces are damaged due to an unintentional accident. If thepharmaceutical composition container 15 is foldable at the portion of theempty chamber 116, folding that portion can further reduce the probability that the swallowing-aid substance 40 and thepharmaceutical composition 80 are mixed. - Further, the pharmaceutical composition container is not limited to one made by adhering two sheets to each other.
FIG. 6 is a partial cross section of thepharmaceutical composition container 16 of the alternative embodiment 4.FIG. 7 is a partial cross section of thepharmaceutical composition container 18 of the alternative embodiment 5. The containers are formed by double-folding one sheet. By forming thepharmaceutical composition containers substance storage chambers substance storage chambers aid substance 40. Note that the pharmaceutical composition container may also be made by adhering the walls of one tube to each other here and there. - Further, in the abovementioned pharmaceutical composition container, the
cutout portions 50 are composed of a V-shaped cutout, but the shape of the cutout in this invention may be another one than a V-shape. - Further, in the abovementioned embodiments, cases were explained where the pharmaceutical composition is a powdered or granular preparation and the swallowing-aid substance is a jelly; however, it is needless to say that the pharmaceutical composition and swallowing-aid substance applied to this invention are not limited thereto. For example, apart from a powdered or granular preparation, the pharmaceutical composition may be a tablet, a capsule or a simple block. The swallowing-aid substance may be an aqueous solution, or may also be honey, custard cream, peanut spread, cheese spread or the like. Moreover, the item formed as the pharmaceutical composition is not limited to an item that is usually treated as a medical drug. For example, the item formed as the pharmaceutical composition may also be a food which is recognized for its effect of improving the health state.
- As the material for the encapsulating item, a wafer made of starch with a thickness of 10 µm as mentioned above, or a variety of other materials conventionally known as edible film materials can be used. The types of the materials include polysaccharides (for example, pullulan, arabinoxylan, decomposition products of guar gum, sodium alginate, carrageenan, agar-agar, pectin, cellulose etc.) and peptide-based substances (for example, gelatin, decomposition products of silk protein, decomposition products of casein etc.). Those materials may be used on a standalone basis or as a combination of two or more types.
- Further, in the abovementioned embodiment, it was explained that
outlet chambers outlet chamber 34, but to provide thecutouts 50 on the encapsulating-item storage chamber 32 or the like, open an aperture by applying shearing force to thosecutouts 50 and hold that aperture against the mouth of the patient. - Further, the structure of the
portions portions sheets portions pharmaceutical composition container 10. This "force that is applied from the outside of thepharmaceutical composition container 10" may be a force that is directly applied to theportions - Further, the swallowing-
aid substance 40 does not have to be directly filled into the space provided in the pharmaceutical composition container.FIG. 8 is a partial cross section of the pharmaceutical composition container 11 of the alternative embodiment 6. The pharmaceutical composition container 11 of this embodiment has a firstbag storage chamber 36, a secondbag storage chamber 38, an encapsulating-item storage chamber 32 and anoutlet chamber 34 formed therein. Same as the encapsulating-item storage chamber 32 and theoutlet chamber 34, the firstbag storage chamber 36 and the secondbag storage chamber 38 are so formed as to maintain air tightness against the external space. - The first
bag storage chamber 36 and the secondstorage bag chamber 38 store and fix the aid-substance storage bag 22. The aid-substance storage bag 22 is directly fixed by the circumferentialstrong seal portion 74 and the thirdweak seal portion 76. The strength of the thirdweak seal portion 76 against breakage is roughly the same as that of the circumferentialstrong seal portion 74. - A swallowing-
aid substance 40 is stored inside the aid-substance storage bag 22. The strength of the aid-substance storage bag 22 on the end at the side facing the firstweak seal portion 70 is such that the end is broken by a force applied from the outside of the pharmaceutical composition container 11. The swallowing-aid substance 40 is sterilized together with the aid-substance storage bag 22, then sandwiched between thesheets strong seal portion 74 etc. are formed. Thereby one end of the aid-substance storage bag 22 breaks when force is applied from the outside of the pharmaceutical composition container 11. When the end breaks, the swallowing-aid substance 40 leaks out into the firstbag storage chamber 36. When, at this time, more force is applied from the outside of the pharmaceutical composition container 11, the firstweak seal portion 70 is broken by the force received from the swallowing-aid substance 40. When the firstweak seal portion 70 is broken, the encapsulatingitem 42 is enclosed in the swallowing-aid substance 40. - The following explains embodiment 2 of this invention. Note that items which are identical with those explained in the embodiment 1 are given identical reference numerals. In this embodiment, the detailed explanation thereof will not be repeated.
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FIG. 9 is a partial cross section of thepharmaceutical composition container 260 of this embodiment. Thepharmaceutical composition container 260 of this embodiment is formed by double-folding one sheet made of a synthetic resin (low-density polyethylene, PET (polyethylene terephthalate) or another resin that is soft so as to be foldable and is heat-sealable, like composite resin), adhering the ends of the double-folded sheet to each other and aligning the outer shape by cutting the adhered portion. - The portion where the ends of the sheet are adhered to each other is the circumferential
strong seal portion 270. The inside of thepharmaceutical composition container 260 is provided with a plurality of spaces. The portions between the plurality of spaces are sealed by a firstweak seal portion 300, a secondweak seal portion 302 and a thirdweak seal portion 304. The firstweak seal portion 300 comprises a first weak-seal zone 310, anintermediate chamber 312 and a second weak-seal zone 314. - One of the spaces inside the
pharmaceutical composition container 260 is the swallowing-aidsubstance storage chamber 280. A swallowing-aid substance 40 is stored inside the swallowing-aidsubstance storage chamber 280. The first weak-seal zone 310 of the firstweak seal portion 300 easily opens by means of the pressure received from the swallowing-aid substance 40 when force is applied to the swallowing-aid substance 40 from the outside of thepharmaceutical composition container 260. When the first weak-seal zone 310 opens, the swallowing-aid substance 40 is pushed out into theintermediate chamber 312. Thereafter, the second weak-seal zone 314, the secondweak seal portion 302 and the thirdweak seal portion 304 sequentially open in the same way. This can be realized because the strength of the firstweak seal portion 300, the secondweak seal portion 302 and the thirdweak seal portion 304 is weak compared to that of the circumferentialstrong seal portion 270. The reason is the same as in the case of the embodiment 1, and therefore a detailed explanation thereof will not be repeated here. - In one type of the spaces inside the
pharmaceutical composition container 260, the first encapsulating-item storage chamber 282 and the second encapsulating-item storage chamber 284 exist. An encapsulatingitem 212 is stored in each of the encapsulating-item storage chambers. The pharmaceutical composition encapsulated by the encapsulatingitem 212 stored in the first encapsulating-item storage chamber 282 and the pharmaceutical composition encapsulated by the encapsulatingitem 212 stored in the second encapsulating-item storage chamber 284 are of different types. - Further, one of the spaces inside the
pharmaceutical composition container 260 is anaperture chamber 286. Theaperture chamber 286 is provided on one end of thepharmaceutical composition container 260 and serves as the chute (in other words, the device for dropping the encapsulatingitem 212 into the mouth of the patient) for the ingestion of the encapsulatingitem 212. - Of the two ends of the
pharmaceutical composition container 260, the end on the opposite side of the end on which theaperture chamber 286 is provided, is thecover 288. The boundary between the swallowing-aidsubstance storage chamber 280 and thecover 288 is the bottomstrong seal portion 272. The strength of the bottomstrong seal portion 272 is the same as that of the circumferentialstrong seal portion 270; therefore the bottomstrong seal portion 272 is not broken even when force is applied to the swallowing-aid substance 40 from the outside of thepharmaceutical composition container 260. Note that, in the explanation of thepharmaceutical composition container 260 of this embodiment, the portion which is more to the side of the second encapsulating-item storage chamber 284 than thecover 288 is referred to as the "container body." -
FIG. 10 is an external view of the portion of thepharmaceutical composition container 260 of this embodiment which corresponds to the rear surface when viewed as shown inFIG. 9 . As is obvious fromFIG. 10 , alabel 262 is adhered to thepharmaceutical composition container 260 of this embodiment. - The features unique to the
pharmaceutical composition container 260 of this embodiment as compared to the pharmaceutical composition containers of the other embodiments are that: thecover 288 is disposed on one end and acover insert portion 320 which is inserted into thiscover 288 is disposed on the other end; the width of thepharmaceutical composition container 260 is larger on thebase 330 of the portion which is inserted into the cover 238; the bottomstrong seal portion 272 and a portion of the secondweak seal portion 302 or a portion of the thirdweak seal portion 304 are folded over to insert the tip of thecover insert portion 320 into the cover 238, and thebase 330 is on the outside of the cover 238.FIG. 11 shows the state where thecover insert portion 320 is inserted into the cover 238 and thebase 330 is on the outside of the cover 238. As is obvious fromFIG. 11 , the portion of thebase 330 is depressed; therefore it is possible to easily to pull out thecover insert portion 320 by inserting a finger thereinto.FIG. 12 is a view of the portion which corresponds to the rear surface when viewed as shown inFIG. 11 , in the state shown inFIG. 11 . The major part of the rear surface of thepharmaceutical composition container 260 is occupied by thelabel 262. - When using the
pharmaceutical composition 260 of this embodiment, a finger is engaged with theabovementioned base 330 and the abovementionedcover insert portion 320 is pulled out of the cover 238 in this state. When thecover insert portion 320 is pulled out, thecover insert portion 320 is placed into the mouth of the patient. The subsequent usage method is the same as in the other embodiments or alternative embodiments thereof. - With the
pharmaceutical composition container 260 of this embodiment, thecover insert portion 320 can easily be pulled out because a finger can be engaged with thebase 330 of thecover insert portion 320. - Further, the
pharmaceutical composition container 260 of this embodiment produces the same effects like that of the embodiment 1. - The following explains embodiment 3 of this invention. Note that items which are identical with those explained in the embodiment 1 are given identical reference numerals. In this embodiment, the detailed explanation thereof will not be repeated.
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FIG. 13 is a partial cross section of thepharmaceutical composition container 400 of this embodiment. Same as in the embodiment 2, thepharmaceutical composition container 400 of this embodiment is formed by double-folding one sheet made of a synthetic resin, adhering the ends of the double-folded sheet to each other and aligning the outer shape by cutting the adhered portion. - The portion where the ends of the sheet are adhered to each other is the circumferential
strong seal portion 410. The inside of thepharmaceutical composition container 400 is provided with a plurality of spaces. The portions between the plurality of spaces are sealed by a firstweak seal portion 440, a secondweak seal portion 442 and a thirdweak seal portion 444. The firstweak seal portion 440 comprises a first weak-seal zone 450, anintermediate chamber 452 and a second weak-seal zone 454. - One of the spaces is the swallowing-aid
substance storage chamber 420. A swallowing-aid substance 40 is stored inside the swallowing-aidsubstance storage chamber 420. When force is applied to the swallowing-aid substance 40 from the outside of thepharmaceutical composition container 400, the firstweak seal zone 450 and the secondweak seal zone 454 sequentially open in the same way as the firstweak seal portion 300, the secondweak seal portion 302 and the thirdweak seal portion 304 in the embodiment 2. The reason why the firstweak seal zone 450 and the secondweak seal zone 454 open in this way is the same as that in the embodiment 2. - In one type of the spaces inside the
pharmaceutical composition container 400, the first encapsulating-item storage chamber 422 and the second encapsulating-item storage chamber 424 exist. An encapsulatingitem 212 is stored in each of the encapsulating-item storage chambers. The pharmaceutical composition encapsulated by the encapsulatingitem 212 stored in the first encapsulating-item storage chamber 422 and the pharmaceutical composition encapsulated by the encapsulatingitem 212 stored in the second encapsulating-item storage chamber 424 are of different types. - One of the spaces is an
aperture chamber 426. Same as theaperture chamber 286 of the embodiment 2, theaperture chamber 426 serves as a chute for the ingestion of the encapsulatingitem 212. - Of the two ends of the
pharmaceutical composition container 400, the end on the opposite side of the end on which theaperture chamber 426 is provided, is thecover 428. The boundary between the swallowing-aidsubstance storage chamber 420 and the cover 478 is the bottomstrong seal portion 412. The strength of the bottomstrong seal portion 412 is the same as that of the circumferentialstrong seal portion 410; therefore the bottomstrong seal portion 412 is not broken even when force is applied to the swallowing-aid substance 40 from the outside of thepharmaceutical composition container 400. - The features unique to the
pharmaceutical composition container 400 of this embodiment as compared with the pharmaceutical composition containers of the other embodiments are that: the cover 478 is disposed on one end; the bottomstrong seal portion 412 and the base of the portion where theaperture chamber 426 is disposed are folded over to insert the portion where theaperture chamber 426 is disposed into the cover 478; thetip 480 of the portion where theaperture chamber 426 is disposed is round; and a part of the edge 482 of the cover 478 is cut out. Note that, in the explanation of thepharmaceutical composition container 400 of this embodiment, the portion which is more to the side of the second encapsulating-item storage chamber 424 than the cover 478 is referred to as the "container body." - When using the pharmaceutical composition 350 of this embodiment, the one of the two ends of the
pharmaceutical composition container 400 on which theaperture chamber 426 is disposed is pulled out of the cover 478. The subsequent usage method is the same as in the other embodiments. - During the production of the
pharmaceutical composition container 400 of this embodiment, thepharmaceutical composition container 400 is folded over in such a manner that the portion where theaperture chamber 426 is disposed and the cut-out edge 482 of the cover 478 face each other.FIG. 14 shows the state in whichpharmaceutical composition container 400 is folded over during production. After thepharmaceutical composition container 400 is folded over, the portion where theaperture chamber 426 is disposed is inserted into the cover 478. At this time, thetip 480 of the portion where theaperture chamber 426 is disposed gets caught at any position of the cut-out edge 482 of the cover 478 and opens the mouth of the cover 478. Since the mouth of the cover 478 is opened, thetip 480 smoothly enters the inside of the cover 478.FIG. 15 shows thepharmaceutical composition container 400 after the portion where theaperture chamber 426 is disposed is inserted into the cover 478. - Further, the
pharmaceutical composition container 400 of this embodiment produces the same effects like that of the embodiment 1. - The following explains embodiment 4 of this invention. Note that items which are identical with those explained in the embodiment 1 are given identical reference numerals. In this embodiment, the detailed explanation thereof will not be repeated.
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FIG. 16 is a partial cross section of thepharmaceutical composition container 500 of this embodiment. Same as in the embodiment 2, thepharmaceutical composition container 500 of this embodiment is formed by double-folding one sheet made of a synthetic resin, adhering the ends of the double-folded sheet to each other and aligning the outer shape by cutting the adhered portion. - The portion where the ends of the sheet are adhered to each other is the circumferential
strong seal portion 510. The inside of thepharmaceutical composition container 500 is provided with a plurality of spaces. The portions between the plurality of spaces are sealed by a firstweak seal portion 540, a secondweak seal portion 542 and a thirdweak seal portion 544. The firstweak seal portion 540 comprises a first weak-seal zone 550, anintermediate chamber 552 and a second weak-seal zone 554. - One of the spaces inside the
pharmaceutical composition container 500 is the swallowing-aidsubstance storage chamber 520. A swallowing-aid substance 40 is stored inside the swallowing-aidsubstance storage chamber 520. When force is applied to the swallowing-aid substance 40 from the outside of thepharmaceutical composition container 500, the firstweak seal zone 550 and the secondweak seal zone 554 sequentially open in the same way as the firstweak seal portion 300, the secondweak seal portion 302 and the thirdweak seal portion 304 in the embodiment 2. The reason why the firstweak seal zone 550 and the secondweak seal zone 554 open in this way is the same as that in the embodiment 2. - In one type of the spaces inside the
pharmaceutical composition container 500, the first encapsulating-item storage chamber 522 and the second encapsulating-item storage chamber 524 exist. An encapsulatingitem 212 is stored in each of the encapsulating-item storage chambers. The pharmaceutical composition encapsulated by the encapsulatingitem 212 stored in the first encapsulating-item storage chamber 522 and the pharmaceutical composition encapsulated by the encapsulatingitem 212 stored in the second encapsulating-item storage chamber 524 are of different types. - One of the spaces is an
aperture chamber 526. Same as theaperture chamber 286 of the embodiment 2, theaperture chamber 526 serves as a chute for the ingestion of the encapsulatingitem 212. - Of the two ends of the
pharmaceutical composition container 500, the end on the opposite side of the end on which theaperture chamber 526 is provided, is thecover 528. The boundary between the swallowing-aidsubstance storage chamber 520 and thecover 528 is the bottomstrong seal portion 512. The strength of the bottomstrong seal portion 512 is the same as that of the circumferentialstrong seal portion 510; therefore the bottomstrong seal portion 512 is not broken even when force is applied to the swallowing-aid substance 40 from the outside of thepharmaceutical composition container 500. Note that, in the explanation of thepharmaceutical composition container 500 of this embodiment, the portion which is more to the side of the second encapsulating-item storage chamber 524 than thecover 528 is referred to as the "container body." -
FIG. 17 is a partial cross section showing one end of thepharmaceutical composition container 500 during the production thereof.FIG. 18 is a perspective view showing one end of thepharmaceutical composition container 500 during the production thereof. The features unique to thepharmaceutical composition container 500 of this embodiment as compared to the pharmaceutical composition containers of the other embodiments will be explained while referring toFIG. 17 andFIG. 18 . The features thereof are that: the bottomstrong seal portion 512 and the base of the portion where theaperture chamber 526 is disposed are folded over to insert the portion where theaperture chamber 526 is disposed into thecover 528; and a melt-bonding margin 514 is disposed on thetip portion 516 which is inserted into thecover 528 on the circumferentialstrong seal portion 510. This melt-bonding margin 514 is folded back like shown inFIG. 18 and melt-bonded to thetip portion 516. - The usage method of the
pharmaceutical composition container 500 of this embodiment is the same as that of the embodiment 3. - Even if there are burrs at the end of the circumferential
strong seal portion 510, those burrs do not easily touch the inside of the mouth of the patient because thepharmaceutical composition container 500 of this embodiment has a structure like that mentioned above. Since the burrs do not easily touch the inside of the mouth, the mouth of the patient is not easily scratched. - Further, the
pharmaceutical composition container 500 of this embodiment produces the same effects like that of the embodiment 1. - The following explains embodiment 5 of this invention. Note that items which are identical with those explained in the embodiment 1 are given identical reference numerals. In this embodiment, the detailed explanation thereof will not be repeated.
-
FIG. 19 is a partial cross section of thepharmaceutical composition container 210 of this embodiment. Same as in the embodiment 2, thepharmaceutical composition container 210 of this embodiment is formed by double-folding one sheet made of a synthetic resin, adhering the ends of the double-folded sheet to each other and aligning the outer shape by cutting the adhered portion. - The portions where the ends of the sheet are adhered to each other are the circumferential
strong seal portions pharmaceutical composition container 210 is provided with a plurality of spaces. The portions between the plurality of spaces are sealed by a firstweak seal portion 240, a secondweak seal portion 242 and a thirdweak seal portion 244. The firstweak seal portion 240 comprises a first weak-seal zone 250, anintermediate chamber 252 and a second weak-seal zone 254. - One of the spaces inside the
pharmaceutical composition container 210 is the swallowing-aidsubstance storage chamber 230. A swallowing-aid substance 40 is stored inside the swallowing-aidsubstance storage chamber 230. When force is applied to the swallowing-aid substance 40 from the outside of thepharmaceutical composition container 260, the firstweak seal zone 250 and the secondweak seal zone 254 sequentially open in the same way as the firstweak seal portion 300, the secondweak seal portion 302 and the thirdweak seal portion 304 in the embodiment 2. The reason why the firstweak seal zone 250 and the secondweak seal zone 254 open in this way is the same as that in the embodiment 2. - In one type of the spaces inside the
pharmaceutical composition container 210, the first encapsulating-item storage chamber 232 and the second encapsulating-item storage chamber 234 exist. An encapsulatingitem 212 is stored in each of the encapsulating-item storage chambers. The pharmaceutical composition encapsulated by the encapsulatingitem 212 stored in the first encapsulating-item storage chamber 232 and the pharmaceutical composition encapsulated by the encapsulatingitem 212 stored in the second encapsulating-item storage chamber 234 are of different types. Further, the outer shape of the encapsulatingitems 212 is different from that of the encapsulatingitem 42 in the embodiment 1. - Further, one of the spaces inside the
pharmaceutical composition container 210 is anaperture chamber 236. Same as theaperture chamber 286 of the embodiment 2, theaperture chamber 236 serves as a chute for the ingestion of the encapsulatingitem 212. - The
pharmaceutical composition 210 of this embodiment is wound in such a manner that the swallowing-aidsubstance storage chamber 230 surrounds theaperture chamber 236. If thepharmaceutical composition container 210 is only wound, it is likely that thepharmaceutical composition container 210 straightens during the time from the completion until the use of thepharmaceutical composition container 210; therefore end of the swallowing-aidsubstance storage chamber 230 of the woundpharmaceutical composition container 210 is fixed with atape 214.FIG. 20 shows the woundpharmaceutical composition container 210. - To use the
pharmaceutical composition container 210 of this embodiment, thetape 214 is peeled off and thepharmaceutical composition container 210 is straightened. When thepharmaceutical composition container 210 extends straightly, theaperture chamber 236 is placed into the mouth of the patient. Thereafter the encapsulatingitem 212 is ingested in the same way as the embodiment 1 or the alternative embodiments thereof. - The
pharmaceutical composition container 210 of this embodiment produces the same effects like that of the embodiment 1. - The pharmaceutical composition container of this invention is suitable for the use as, for example, a container for the ingestion of a drug. Specifically, the pharmaceutical composition container of this invention is suitable for the use as a container for the ingestion of a drug, wherein the drug is filled into the container by a system as mentioned below. Such system is one wherein a plurality of auger filling machines are set up, a transport system and weighing system are added, the filling machines, the transport system and the weighing system are connected to a medical-drug production line and automatic operation is performed over a long time.
-
- 10, 11, 12, 14, 15, 16, 18, 210, 260, 400 and 500: pharmaceutical composition container
- 20: sheet
- 22: aid-substance storage bag
- 30, 100, 102, 104, 106, 230, 280 and 520: swallowing-aid substance storage chamber
- 32 and 110: encapsulating-item storage chamber
- 34 and 150: outlet chamber
- 36: first bag storage chamber
- 38: second bag storage chamber
- 40: swallowing-aid substance
- 42, 120 and 212: encapsulating item
- 50: cutout
- 60: predetermined aperture part
- 70, 240, 300, 440 and 540: first weak seal portion
- 72, 242, 302, 442 and 542: second weak seal portion
- 74, 220, 222, 270, 410 and 510: circumferential strong seal portion
- 76, 244, 304, 444 and 544: third weak seal portion
- 80: pharmaceutical composition
- 90: patient
- 112, 232, 282, 422 and 522: first encapsulating-item storage chamber
- 114, 234, 284, 424 and 524: second encapsulating-item storage chamber
- 116: empty chamber
- 130: first tapered portion
- 140: second tapered portion
- 214: tape
- 236, 286, 426 and 526: aperture chamber
- 238, 288, 428, 478 and 528: cover
- 250, 310, 450 and 550: first weak seal zone
- 252, 312, 452 and 552: intermediate chamber
- 254, 314, 454 and 554: second weak seal zone
- 262: label
- 272, 412 and 512: bottom strong seal portion
- 320: cover insert portion
- 330: base
- 480: tip
- 482: edge
- 516: tip portion
Claims (6)
- A pharmaceutical composition container equipped with a plurality of spaces, wherein the portions between two adjoining aforementioned spaces are sealed, the aforementioned portions between two adjoining spaces open when force is applied from the outside of the aforementioned pharmaceutical composition container, a swallowing-aid substance is stored in a swallowing-aid substance storage chamber which is at least one of the aforementioned spaces, an encapsulating item is stored in an encapsulating-item storage chamber which is at least one of the aforementioned spaces, the aforementioned encapsulating item contains a pharmaceutical composition, at least the surface of the aforementioned encapsulating item melts in the ingredients of the aforementioned swallowing-aid substance, and a predetermined aperture part is provided in which an aperture is to be formed that interconnects the outside of the aforementioned pharmaceutical composition container with the aforementioned spaces.
- The pharmaceutical composition container described in claim 1, wherein the aforementioned swallowing-aid substance contains water, and at least the surface of the aforementioned encapsulating item melts in the ingredients of the aforementioned swallowing-aid substance due to the material of the aforementioned encapsulating item being a water-soluble substance.
- The pharmaceutical composition container described in claim 2, wherein the aforementioned swallowing-aid substance is a water-containing jelly and the aforementioned water-soluble substance is starch.
- The pharmaceutical composition described in claim 1, wherein at least one of the aforementioned spaces is disposed between the aforementioned swallowing-aid substance storage chamber and the aforementioned encapsulating-item storage chamber.
- The pharmaceutical composition container described in claim 1, wherein the aforementioned encapsulating item is tightly sealed.
- A pharmaceutical composition container equipped with at least three spaces, wherein the portions between two adjoining aforementioned spaces are sealed, the aforementioned portions between two adjoining spaces open when force is applied from the outside of the aforementioned pharmaceutical composition container, a swallowing-aid substance is stored in a swallowing-aid substance storage chamber which is at least one of the aforementioned spaces, an encapsulating item is stored in an encapsulating-item storage chamber which is at least one of the aforementioned spaces, the aforementioned encapsulating item contains a pharmaceutical composition, at least the surface of the aforementioned encapsulating item melts in the ingredients of the aforementioned swallowing-aid substance, and an aperture chamber which is at least one of the aforementioned spaces is provided with an aperture that interconnects the outside of the aforementioned pharmaceutical composition container with the aforementioned spaces.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP2009/055972 WO2010109610A1 (en) | 2009-03-25 | 2009-03-25 | Pharmaceutical composition container |
PCT/JP2010/055212 WO2010110366A1 (en) | 2009-03-25 | 2010-03-25 | Medicinal composition container |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2412357A1 true EP2412357A1 (en) | 2012-02-01 |
EP2412357A4 EP2412357A4 (en) | 2014-10-29 |
Family
ID=42780319
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10756162.3A Withdrawn EP2412357A4 (en) | 2009-03-25 | 2010-03-25 | Medicinal composition container |
Country Status (6)
Country | Link |
---|---|
US (1) | US20120012480A1 (en) |
EP (1) | EP2412357A4 (en) |
JP (1) | JPWO2010110366A1 (en) |
KR (1) | KR20110131295A (en) |
CN (1) | CN102438575A (en) |
WO (2) | WO2010109610A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5931280B2 (en) * | 2013-10-29 | 2016-06-08 | 株式会社モリモト医薬 | Package, method for manufacturing package, and apparatus for manufacturing package |
WO2015114749A1 (en) * | 2014-01-29 | 2015-08-06 | 株式会社モリモト医薬 | Oral medication-holding cell, strip packaging, and method for manufacturing oral medication-holding cells |
JP6514547B2 (en) * | 2015-03-31 | 2019-05-15 | 株式会社Uacj | Double package |
GB2542630A (en) * | 2015-09-28 | 2017-03-29 | Medimauve Ltd | Sachet system |
US20220133596A1 (en) * | 2020-11-05 | 2022-05-05 | Purosil LLC | Device and method for assisting pill swallowing |
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GB8911878D0 (en) * | 1989-05-24 | 1989-07-12 | Allen Nicholas J | Mixing device |
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JPH10291538A (en) * | 1997-04-17 | 1998-11-04 | Material Eng Tech Lab Inc | Drug container |
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2009
- 2009-03-25 WO PCT/JP2009/055972 patent/WO2010109610A1/en active Application Filing
-
2010
- 2010-03-25 JP JP2011506110A patent/JPWO2010110366A1/en active Pending
- 2010-03-25 US US13/257,424 patent/US20120012480A1/en not_active Abandoned
- 2010-03-25 EP EP10756162.3A patent/EP2412357A4/en not_active Withdrawn
- 2010-03-25 CN CN2010800119716A patent/CN102438575A/en active Pending
- 2010-03-25 WO PCT/JP2010/055212 patent/WO2010110366A1/en active Application Filing
- 2010-03-25 KR KR1020117024735A patent/KR20110131295A/en not_active Application Discontinuation
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JPH10234820A (en) * | 1996-12-25 | 1998-09-08 | Takeda Chem Ind Ltd | Granular agent jointly using dense fluid substance and double chamber type container therefor |
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Also Published As
Publication number | Publication date |
---|---|
EP2412357A4 (en) | 2014-10-29 |
US20120012480A1 (en) | 2012-01-19 |
CN102438575A (en) | 2012-05-02 |
JPWO2010110366A1 (en) | 2012-10-04 |
KR20110131295A (en) | 2011-12-06 |
WO2010109610A1 (en) | 2010-09-30 |
WO2010110366A1 (en) | 2010-09-30 |
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