JPH10234820A - Granular agent jointly using dense fluid substance and double chamber type container therefor - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a preparation which allows simply and smoothly dosing thereof and a container therefor by arranging a granular agent jointly used with a dense fluid substance such as jelly to facilitate swallowing and handling. SOLUTION: A plurality of housing chambers 5 and 6 are sectioned to be mutually communicable and form a double chamber type container. A granular agent 7 is housed being sealed into some of the housing chambers 6 while a dense fluid substance 8 is housed being sealed into other housing chambers 6. The housing chambers are worked to communicate with each other by an external operation to collect and mix the granular agents and the dense fluid substances 8. The mixture thus obtained is taken out from an takeoff port 10 provided on either the housing chambers 5 or 6.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a powdery or granular preparation which is used in combination with a thick fluid substance such as jelly and the like, and more particularly to a preparation which can be easily swallowed and handled and which can be taken easily and without difficulty, and a container thereof.

[0002]

BACKGROUND OF THE INVENTION Orally administered solid preparations include relatively large ones such as pills, tablets and capsules and fine powders and granules such as powders and granules. Generally, it is swallowed using water or the like. However, especially for the elderly and infants, the sick, etc., there is a problem that large solid preparations such as the above tablets cannot be swallowed easily,
On the other hand, in the case of fine powders and granules, they may spread all over the mouth or adhere to the throat and remain partially indefinitely. There is a problem that the patient strongly feels resistance to taking the drug because he / she feels strong. In addition, it is difficult to take the patient with the highly fluid water in the lying state, so that the patient has to wake up every time the patient takes the tablet, which may cause a heavy burden on the patient.

[0003]

2. Description of the Related Art Conventionally, as a preparation which solves the above problems and is easy to swallow and can be taken without resistance, for example, as shown in JP-A-5-163151, a gelling agent is added to an appropriate amount of water, A jelly-like preparation was prepared by mixing a medicine with the mixture and preparing a jelly-like preparation (hereinafter referred to as prior art 1), or jelly or a high-viscosity liquid immediately before administration as described in, for example, JP-A-5-139958. There is one in which a seamless capsule is mixed with the mixture (hereinafter referred to as Conventional Technique 2).

[0004]

However, most of the powdery and granular agents are generally liable to be decomposed or deteriorated by moisture, so that they are preliminarily formed into a jelly-like material containing a large amount of water as in the prior art 1. I can't put it. On the other hand, in the above-mentioned prior art 2, jelly or the like must be prepared immediately before each dose, and the operation for simply swallowing a small amount of a pharmaceutical is extremely complicated, and the operation of preparing the jelly or the like is troublesome. In order to simplify the preparation operation, for example, for a plurality of patients in a hospital, jelly or the like for a large number of people may be prepared at a time, and the medicine may be mixed, and then subdivided for each patient. Conceivable. However, in this case, uniform mixing of the pharmaceuticals is not easy due to the high viscosity of the jelly and the like, and the pharmaceuticals in the subdivided containers are likely to have a quantitative variation, and it is difficult to perform in-hospital preparation under aseptic conditions. There is also a problem that is.

The present invention has been made to solve the above-mentioned problems, and to provide a preparation which can be swallowed and handled easily by using a thick flowable substance such as jelly in combination with a powdery agent, and which can be taken simply and without difficulty, and a container thereof. Subject.

[0006]

Means for Solving the Problems In order to solve the above-mentioned problems, the present invention will be described with reference to FIGS. 1 to 6 showing an embodiment of the present invention. . That is, the present invention 1 according to the present invention stores the granular agent (7) and the thick fluid substance (8) prepared in advance in sealed compartments (5.6, 6a, 6b) partitioned from each other, and Containment room
(5.6.6a.6b) are communicated with each other to assemble the powdery and granular agent (7) and the thick fluid substance (8) so that they can be taken in a mixed state. It is a powdery agent to be used in combination.

According to the second aspect of the present invention, a plurality of accommodation rooms (5.6.6a.6) are provided.
b) are divided so as to be able to communicate with each other, the powdery and granular agent (7) is sealed in one of the storage chambers (5), and the other storage chamber (6.6a
・ The concentrated fluid substance (8) is sealed and stored in 6b), and the respective storage chambers (5.6.6a, 6b) are communicated with each other based on an operation from the outside, so that the powdered granular agent (7) and the concentrated fluid substance ( 8), and after mixing and mixing, the above-mentioned mixture can be taken out from the outlet (10) provided in any one of the storage chambers (5.66a-6b). And a powder container.

[0008] Here, the concentrated fluid substance is particularly preferably an edible substance, for example, a food having relatively high viscosity but fluidity and easy to swallow, and specifically, gelatin such as jelly or agar, It consists of a gelled food made of starch or the like, or a mixture of single or plural kinds such as honey, custard cream, pastes and the like.

The viscosity of the thick fluid substance is 100
If it is about 30,000 centipoise, handling and swallowing are easy and preferable.

[0010] The above-mentioned powdery and granular preparations are preparations having a fine particle size such as powdery powders and fine granules, and those having a particle size of 400 µm or less are well surrounded by a thick fluid substance and can be used in the mouth of a user. It is preferable because it does not cause roughness, and the particle size is more preferably 200 μm or less, and further preferably 100 μm or less.

Further, it is desirable that the powdery and granular agent is subjected to a treatment for suppressing the bitterness of the medicinal component and the like. Examples of this treatment include, in addition to mixing a sweetener or the like, coating the particle surface with a masking agent, granulating into fine particles, and the like. The reason why the granulation suppresses bitterness is that the surface area with respect to the volume is reduced, the solidification by the binder makes it difficult to dissolve and delays the stimulation of the taste, and the ratio of exposure of the medicinal component to the surface by mixing the binder It is conceivable that this will decrease.

The configuration in which the plurality of storage chambers can communicate with each other refers to a configuration in which the communication between the storage chambers can be eliminated or invalidated by an external operation. A configuration that allows the seal between the chambers to be peeled off,
A configuration in which the clips between the storage chambers can be removed by removing the clips, a configuration in which the partition between the storage chambers can be broken or moved, and a valve that closes the communication passage between the storage chambers can be opened And the like.

It should be noted that, when the above-mentioned powdery and granular agents and the thick fluid substance are aggregated and mixed, the two do not necessarily need to be mixed uniformly, but in a state in which the powder and granular agent body is non-uniformly dispersed in the thick fluid substance. There may be.

[0014]

[Function] Since the thick fluid substance and the particulate agent are hermetically contained in the compartments respectively partitioned, it is easy to store each of them in an aseptic or sterile state. It is not affected by decomposition or the like due to moisture contained in the thick fluid substance.

[0015] At the time of taking, both are taken out and taken in a mixed state by a simple operation of merely connecting the respective accommodating chambers accommodating the thick fluid substance and the particulate agent to each other.
At this time, since the powdery granule is wrapped in the thick fluid substance, it is easily swallowed by the flow of the thick fluid substance while giving the patient a delicious feeling of the thick fluid substance instead of the bitterness due to the medicinal ingredient.

The above-mentioned powdery and granular preparations are preparations having a fine particle diameter such as powdery powders and fine granules, and those having a particle diameter of 400 μm or less are well surrounded by a thick fluid substance and have a rough texture in the mouth of a user. The particle size is preferably 200 μm or less, and more preferably 100 μm or less.

[0017]

Embodiments of the present invention will be described below with reference to the drawings. FIG. 1 is a partially cutaway perspective view of a multi-chamber container containing a thick fluid substance and a particulate agent, showing a first embodiment of the present invention.

As shown in FIG. 1, a multi-chamber container (1)
Attach the periphery of two sheets (2.2) and seal (3)
And a weak seal portion (4) is formed in the middle portion, and the upper and lower two storage chambers (5.6) are partitioned between the two sheets (2.2) through the weak seal portion (4). It is formed. The upper storage chamber (5) accommodates a fine-grained agent (7) subjected to surface treatment, and the lower storage chamber (6) accommodates a jelly (8), which is a thick fluid substance prepared in advance, in a sealed state. I have. The sign
(9) shows a cutout, which can be formed by breaking the cutout at the time of taking and removing the upper end to form a takeout opening (10) indicated by a virtual line.

Although the weak seal portion (4) divides the two storage chambers (5, 6) into upper and lower sections, they can be separated by a relatively weak force, and one of the storage chambers, for example, the lower storage chamber (5) is separated. 6) It is easily peeled by pressing to increase the internal pressure. Therefore, in order to prevent this peeling during storage, the entire multi-chamber type container (1) is folded in two at the weak seal portion (4), so that even if an external force is applied to each of the storage chambers (5, 6). The weak seal portion (4) does not peel off, and the fine granule (7) and the jelly (8) are securely separated and stored.

Fine granules (7) contained in the double-chambered container (1)
In order to take the jelly, etc., first, the lower housing chamber (6) is pressed to cause the jelly (8) to flow upward, and the weak pressure is applied by the flow pressure.
To spread the jelly (8) and the granule (7) together. Then, the jelly (8) is moved in the upper and lower storage chambers (5.6) communicating with each other by pressing various parts from the outside of the multi-chamber container (1), and the jelly (8) And fine granules (7).

Next, the cut end provided on the upper end side
From (9), break the double-chamber container (1) horizontally to take out
(10) is formed, and a mixture of jelly (8) and fine granule (7) is squeezed out or sucked out from the outlet (10). The removed mixture is a fine granule (7) jelly.
Since it is covered with (8), it is easily swallowed by the fluidity of jelly (8) while giving the flavor of jelly (8) instead of the bitterness due to the medicinal component of fine granule (7).

In the present embodiment, the outlet (10) is formed in the upper storage chamber (5) containing the fine granule (7), so that the jelly (8) is merely pushed up from the lower side to make the jelly (8). The fine granule (7) can be wrapped in the jelly (8) by the flow of (8), and the mixing operation in the multi-chamber type container (1) does not always need to be sufficiently performed.

FIG. 2 is a partially cutaway front view showing a second embodiment of the present invention. In the second embodiment, a large number of multi-chamber containers (1...) Are formed in series in a state of being connected to the left and right by laminating two front and rear sheets (2.2). An easy break line (11) consisting of a perforation is formed at an intermediate portion so that the mold containers (1) can be individually separated. As in the first embodiment, each of the two-chamber containers (1) has two storage chambers (5, 5) partitioned vertically through a weak seal portion (4) formed at an intermediate portion in the vertical direction. 6) is formed, and the fine granule (7) is placed in the upper storage chamber (5), and the lower storage chamber (5) is
In (6), jelly (8) prepared in advance is housed in a sealed state.

In the series of multi-chamber containers (1), one multi-chamber container (1) is separated by breaking the line of easy breaking (11) immediately before taking it. The weak seal portion (4) is peeled off by the same operation as described above, and the fine granule (7) and the jelly (8) are assembled and mixed. Cut the cut line (11) above
(9) is provided, and the take-out opening can be formed by breaking the multi-chamber type container (1) from the cut-out (9) as in the first embodiment. However, in the second embodiment, since the take-out opening (10) can be formed by piercing the straw (12) indicated by the imaginary line into the lower housing chamber (6), the cut-out (9) is formed. It can be omitted.

FIG. 3 is a vertical sectional front view showing a third embodiment of the present invention. In the third embodiment, the clip (13) replaces the weak seal portion of the first embodiment and the like with the communication portion (14).
, The first storage chamber (5) for storing the fine granule (7) and the second storage chamber (6) for storing the jelly (8) are not communicated.

Two operating plates (15, 15) are simultaneously held at one end of the portion held by the clip (13) via the communicating portion (14). For example, by pulling each other end of 15), the one end side is expanded by levering the intermediate projection (16), or two operation plates (1
By pulling the other ends of 5) apart from each other, the clip (13) can be pushed out and removed. Then, when the clip (13) is removed, the two storage chambers are connected via the communication portion (14).
(5, 6) communicate with each other, and the fine granule (7) and the jelly (8) are mixed and taken as in the first embodiment.

FIG. 4 is a perspective view showing a fourth embodiment of the present invention. In this embodiment, the inside of the cylindrical multi-chamber container (1) is divided into a first storage chamber (5) and a second storage chamber (6) by a shielding disk (17). The shielding disk (17) is formed of a hard resin, and the first storage chamber (5) and the second storage chamber (6) communicate with each other by rotating or breaking by a pressing operation from the outside. It is configured as follows. Then, the take-out portion (18) provided at the outer end of the first storage chamber (5) is cut off at the leading end of the take-out portion (18), so that the take-out opening (10) is opened and the same as in the first embodiment and the like. The fine granules wrapped in jelly are taken out.

In each of the above embodiments, a multi-chamber container having two storage chambers has been described. However, in the present invention, three or more storage chambers are provided so that a thick fluid substance such as jelly is stored in a plurality of storage chambers. May be configured. In this case, by arranging the thick fluid substance storage chambers on both sides of the powder agent storage chamber, respectively, the rich fluid substance flows from both sides of the powder agent, and the mixing of both can be performed better and easier. it can. In the case of administering a plurality of kinds of powdery and granular preparations, the preparations can be divided and accommodated in a plurality of accommodation chambers.

FIG. 5 is a vertical sectional front view showing a fifth embodiment of the present invention. This double-chambered container (1) has a syringe-like structure, and has a cut-off portion (18) at the tip of a hard material cylindrical body (19).
Fix the take-out opening (10) sealed with, fix the finger grip (20) at the rear end of the cylindrical body (19), and push the stopper into the inside of the rear end.
A push rod (22) can be screwed behind the push plug (21) by disposing the (21) and sealing the inside. The rear end of the finger grip (20) has a leak prevention sheet
(88) is attached.

A partition plug (23) is slidably disposed at an intermediate portion inside the cylindrical body (19).
The inside of the cylindrical body (19) is partitioned into a front-end-side accommodation room (5) and a rear-end-side accommodation room (6) by (23). In addition, four bypass paths (24) are formed on the inner surface of the cylindrical body (19) by bulging the distal end side of the partition wall (23) of the peripheral wall of the cylindrical body (19). Bypass road (2
4) The length is formed longer than the thickness of the partition plug (23). A fine granule (7) is housed in the front-end-side accommodation chamber (5), and a jelly (8) is housed in the rear-end-side accommodation chamber (6).

At the time of taking the medicine, the breaking part (18) is broken off to open the take-out opening (10). Push. By this operation, first, the partition plug (23) moves through the jelly (8) and the bypass path (24) is moved to the rear end side storage chamber (6).
Open to And jelly through this bypass (24)
(8) flows into the tip side accommodation room (5) and is mixed with the fine granule (7). When the push rod (22) is further pushed in, all the jelly (8) flows into the distal-end-side accommodating chamber (5), and the push-in stopper (21) comes into contact with the partition stopper (23). ) And partition stopper
(23) moves together with the distal end. As a result, the mixture of the fine granules (7) and the jelly (8) is taken out at the tip outlet.
It is extruded from (10) and is taken smoothly as it is.

When the push plug (21) is pushed into the cylindrical body (19) and the push plug (21) is located on the distal end side of the bypass path (24), it remains in the bypass path (24). The mixture may come out of the cylinder (19), but in the present embodiment, such a danger is eliminated because the leakage prevention sheet (88) is provided. Further, instead of the leakage prevention sheet (88), a leakage prevention device (89) may be provided at a predetermined corresponding position of the pushing rod (22). In FIG. 5, the leak prevention device (89) is a disk 89 (shown by imaginary lines).
It consists of.

FIG. 6A is a longitudinal sectional front view showing a sixth embodiment of the present invention, and FIG. 6B is a plan view of a sealing material. In the sixth embodiment, the double chamber type container (1) has two jelly accommodation chambers.
(6a, 6b) and a fine-grained material storage chamber (5) arranged therebetween.

Each of the accommodation chambers (5.6a, 6b) is formed in a unit shape. That is, as shown in FIG. 6 (A), the front-end-side jelly storage chamber (6a) is provided with a take-out port (10) having a break-off portion (18) at the front end, and a connection flange (F1) at the rear end peripheral edge. After forming and storing jelly (8) inside, a sealing material (S
Sealed by 1). Also, an intermediate granule storage room (5)
And the rear end side jelly storage chamber (6b) are both formed in a cylindrical shape, forming connection flanges (F2 to F5) on the periphery of both the front and rear openings, and the fine granule (7) or After accommodating the jelly (8), each opening is sealed with a sealing material (S2 to S5).

In this embodiment, since each of the storage chambers is formed in a unit shape, it is easy to prepare and store the powder or granular agent or the thick fluid substance in an aseptic or sterile state. There is an advantage that the type of the thick fluid substance can be easily changed and combined.

The front-end-side jelly storage chamber (6a), the fine-grain-agent storage chamber (5) and the rear-end-side jelly storage chamber (6b) are connected and fixed in sequence via connection flanges (F1 to F5). A piston guide cylinder (25) is connected and fixed behind the rear end side jelly storage chamber (6b). A finger grip (20) is formed at the rear end of the piston guide cylinder (25), and a piston (26) is slidably disposed inside.

The operation of taking the fine granule (7) is to first break off the break-off portion (18) at the tip and then push the piston (26). As a result, each seal material (S1 to S5) is broken, and the jelly (8) in the rear end side jelly storage chamber (6b) is changed to the fine granule storage chamber (5).
And moves to the front end side integrally with the fine granule (7), and further flows into the front end side jelly accommodating chamber (6a). As a result, the fine granule (7) is sandwiched between the jellies (8.8) and is well mixed, and is sufficiently wrapped and pushed out from the outlet (10) at the tip.

FIG. 6 (B) shows a structure provided as necessary. The break guide portion (90) is attached to the seal material (S1 to S5) so that the tearing shape of the seal material (S1 to S5) can be specified. Is formed. The break guide portion (90) is formed by forming a portion thinner than the original thickness of the sealing material (S1 to S5). With this configuration, the piston (2
6) When pressed, the sealing material (S1 to S5) breaks irregularly,
The cutout of the sealing material (S1 to S5) can be prevented from clogging the outlet (10). FIG. 6B shows a case where the break guide portion (90) is formed in a cross shape.

FIG. 13 is a vertical sectional front view showing an application example of the sixth embodiment. This application example is different from the sixth embodiment shown in FIG. 6 in that the ends of the sealing materials (S1 to S5) are pulled out from the connection flanges (F2 to F5) and the pulling tools (G1 to G3) are used for the sealing material (G1 to G3). S1-S
5) can be pulled out from the cylindrical body (19). The ends of the sealing materials (S1 to S5) are sealed so that no germs enter. In addition, each pulling tool (G1 ~ G3)
After the sealing material (S1 to S5) is pulled out of the cylindrical body (19), the mixture inside the cylindrical body (19) is still connected to the connection flange (F2 to F5).
It is configured not to leak from

According to this application example, the sealing material (S1 to S5) is pulled out immediately before the jelly (8) is pushed by the piston (26), so that the sealing material (S1 to S5) is placed inside the cylindrical body (19). And the jelly (8) can be collectively mixed in a state in which no is present. In all of the first to sixth embodiments, the combination of fine granules and jelly has been described. However, the present invention can be applied to powdered powders in addition to fine granules, and a thick fluid substance other than jelly can be appropriately used. It goes without saying that they can be applied in combination.

Next, the seventh to ninth embodiments will be described. The configuration of the seventh embodiment to the ninth embodiment is different from the first embodiment in that a powdery / granular agent storage chamber (31) for containing a granular / granular agent (7) and a thick fluidized substance storage chamber (32) for containing a thick fluidized substance (8) are provided. Division means
(33), a take-out port (10) is provided on the side of the powdery and granular agent storage chamber (31), and the partitioning means (3
An externally operable communication path forming means (34) for connecting (3) to a communication state
And an externally operable push-out operation means (35) for pushing the thick fluid substance (8) in the thick fluid substance storage chamber (32) into the granular agent storage chamber (31). Then, the operator brings the powdery / granular agent (7) in the powdery / granular agent storage chamber (31) and the thick fluidized substance (8) in the thick fluidized substance storage chamber (32) into communication with each other by the communication path forming means (34). After that, the extruding operation means (35) pushes the concentrated fluid substance (8) into the outlet (10) of the granular agent storage chamber (31) in a state where the granular agent (7) is mixed with the thick fluid substance (8). According to this configuration, since the thick fluid substance (8) is pushed out to the powder agent storage chamber (31) by the extrusion operation means (35), the powder agent (7) and the thick fluid substance (8) are extruded. ) Can be smoothly performed.

FIGS. 7A, 7B and 7C are longitudinal sectional views showing the structure of a multi-chamber type container according to a seventh embodiment of the present invention. In this double-chamber container (1), the distal end region of a cylindrical body (36) made of a hard material is formed in a funnel shape, and the tube portion (3) of the funnel-shaped portion (54) is formed.
An outlet (10) sealed with a lid sheet (38) is provided at the end of (7), and a partition wall (39) is provided at the lower end of the pipe (37) to form a lid sheet (3).
8 and a partition wall (39) form a closed powder / granular agent storage chamber (31), which contains a powder / granular agent (7). The cylindrical body (3
The feeding device (40) is fitted and fixed from the rear end of 6a). The partition wall (39) is formed of a resin sheet or the like.

The feeder (40) has a push plug (42) having a female screw hole (41) at the rear end, and a feed dial (44) on which a feed screw (43) is erected. By rotating the feed dial (44), the push-in plug (42) can be sent out to the distal end side. On the tip side of the push-in plug (42),
A projecting tool (45) penetrating the partition wall (39) is formed to project. Cylindrical body (36) surrounded by partition wall (39) and push-in plug (42)
A thick fluid substance storage chamber (32) is formed in the inner space of the present embodiment, and in this embodiment, jelly (55) is housed as the thick fluid substance (8). As shown in FIG. 7 (C), the outer shape of the push-in plug (42) provided with the protruding tool (45) is in close contact with the funnel-shaped part (54) when in contact with the funnel-shaped part (54). It is formed in a shape.
The feeder (40) is not limited to the dial type, but may be a piston rod or the like.

As shown in a longitudinal sectional view in FIG. 7A, the projecting tool (45) is constituted by a pipe body (47) having a break-through portion (46) that breaks through the partition wall (39) at the tip. A number of peripheral holes (49) communicating with the vertical holes (48) are provided on the peripheral surface of the pipe (47). In addition,
The break-through portion (46) can break the partition wall (39), and is selected to have a shape that does not hurt the patient.

FIG. 8 (A) is a front view showing another example of the configuration of the projecting tool (45), and FIG. 8 (B) is a cross-sectional view thereof.
5) is constituted by a rod body (51) provided with at least one slit-shaped jelly passage groove (50) on the peripheral surface. FIG. 8 (A) (B)
In the configuration shown in (1), the rod (5
An example in which four grooves (50) are formed on the peripheral surface of 1) is shown. FIG. 9 (A) is a longitudinal sectional view showing still another configuration example of the projecting tool (45), and FIG. 9 (B) is a transverse sectional view of the projecting tool (45).
Is composed of a gutter-shaped body (52) having a streamline breakthrough (46) at the tip. The recess (53) of the gutter (52) constitutes a passage for jelly passage. The projecting tool (45) and the feeding device (40) constitute the communication path forming means (34), and the push-in plug (42) and the feeding device (40) constitute the pushing operation means (35). Make up.

When using the seventh embodiment, after removing a hygienic sheet (not shown) covering the funnel-shaped portion (54) of the cylindrical body (36), the funnel-shaped portion (54) of the cylindrical body (36) is removed. Keep it in the patient's mouth. In this state, when the feed dial (44) is manually rotated in the clockwise direction, for example, the push-in plug (42) moves to the distal end side as shown in FIG. It will break through the wall (39), but in this state it will break through
Since (46) does not block all the broken portions of the partition wall (39), the granular material (7) is filled with the jelly (5
5) It will fall on top and into the vertical hole (48). When the feed dial (44) is further rotated from this state, the protrusion (45)
The jelly (55) containing the granular material (7) flows from the peripheral hole (49). Then, in the operation of shifting from the state of FIG. 7 (B) to the state in which the protruding tool (45) is exposed from the outlet (10) as shown in FIG. 7 (C), the jelly containing the powdery and granular agent (7) ( 55) is a peripheral hole (49)
Will be ejected. This dispensed jelly (55)
The patient can lick with the tongue and take it.

According to the configuration of the seventh embodiment, a single operation of turning the feed dial (44) requires only one operation.
An operation of collecting and mixing (7) and jelly (55) and an operation of opening the outlet (10) can be performed. In other words, the patient can take the drug by simply turning the feed dial (44) without being conscious of the collective mixing operation and the opening operation, so that there is an advantage that the patient with a physical disability can easily take the drug. In addition, multi-chamber containers
(1) The projecting device (45) as the communication path forming means (34) disposed inside performs the operation of forming the communication path and opening the take-out opening (10) from the inside, so that contamination of various bacteria can be prevented. . Furthermore, since the push plug (42) as the pushing operation means (35) pushes out the jelly (55) from the thick fluid substance storage chamber (32) side to the powdery agent storage chamber (31), Agent (7) is a multi-chamber container
(1) It is possible to eliminate the possibility that a large amount will remain inside.

FIG. 10 is a view showing the structure of a multi-chamber type container according to an eighth embodiment of the present invention. FIG. 10 (A) is a partially cutaway perspective view, and FIGS. It is a schematic diagram for explaining. Note that, in the eighth embodiment, the seventh
Members performing substantially the same functions as those of the embodiment will be described with the same reference numerals. In the eighth embodiment, a multi-chamber container
(1) is a cylindrical powdery and granular agent storage chamber (31) separated by a partition wall (39) at the tip of a flexible resin storage bag (58) having an elastic bellows (57). ), And a take-out port (10) is provided at the upper end of the powdery / granular agent storage chamber (31), and the take-out port (10) is sealed with the same flexible resin lid sheet (59). An extruded hard body (60) is fixed to the bottom of the storage bag (58), and a protruding tool (45) penetrating the partition wall (39) protrudes from the extruded hard body (60). . The inner space including the bellows (57) constitutes the thick fluid substance storage chamber (32). Figure 10 before use
As shown in (A), jelly (5
5) is accommodated, and the bellows portion (57) is in an extended state by accommodating the jelly (55). The configuration of the protruding tool (45) shown in FIG. 10 adopts the configuration of FIG. 9, but the configuration shown in FIGS. 7 and 8 can also be employed. In addition, projecting tool (45), bellows (5
7) and the extruded hard body (60) constitute the communication path forming means (34), and the bellows portion (57) and the extruded hard body (60) constitute the extruding operation means (35).

When using the eighth embodiment, the hygiene sheet (not shown) is removed, and the upper part of the cylindrical shape having the powdery and granular material accommodating chamber (31) is contained in the mouth of the patient. By holding the body (60) and the upper end surface (57a) of the bellows part (57) with fingers, and shrinking the bellows part (57) as shown in FIG. The projecting tool (45) moves to the distal end side, and the piercing portion (46) pierces the partition wall (39). In this state, similarly to the seventh embodiment, the granular material (7) falls on the jelly (55) of the thick fluid substance storage chamber (32). When the bellows portion (57) is further contracted from this state and the extruded hard body (60) is moved to the distal end side, as shown in FIG.
The jelly (55) containing the granular material (7) comes out through the concave portion (53) of the projecting tool (45) projecting from (10).

According to the configuration of the eighth embodiment, the bellows portion
(57) is shrunk and the projecting tool (45) is taken out from the outlet (10), and only one operation is required to collect and mix the powder and granular agent (7) and jelly (55), and to remove the outlet (10). Opening operation can be performed,
Problems such as contamination of various bacteria can be eliminated. Further, there is an advantage that the feeding device (40) as shown in FIG. 7 is unnecessary and the configuration is simple. In the configurations of the seventh embodiment and the eighth embodiment, a configuration in which a passage for jelly passage is formed in the projecting tool (45) has been proposed. However, such a passage is provided in the projecting tool (45). The cross-sectional area of the powder-granule storage chamber (31) and the cross-sectional area of the outlet (10) are larger than the cross-sectional area of the projecting device (45). And the jelly (55) may be sent out.

FIGS. 11A, 11B and 11C are schematic longitudinal sectional views showing the structure of a multi-chamber container according to the ninth embodiment.
This multi-chamber type container (1) has a cylinder portion (64) composed of a small-diameter portion (62) and a large-diameter portion (63), and a partition plug for dividing the small-diameter portion (62) and the large-diameter portion (63). (65), a piston member (67) provided with a push plug (66) for plugging the bottom of the large diameter portion (63), and the partition plug (65) through the push plug (66) to the large diameter portion (63) side. A pulling device (68) that can be pulled to the end of the small-diameter portion (62) as the outlet (10), the outlet (10) is closed with a lid sheet (69), and the partition plug (65) is closed. ) Is used as the powdery and granular agent storage chamber (31), and the internal space of the cylinder (64) between the partition plug (65) and the push-in plug (66) is configured as the thick fluid substance storage chamber (32). I have.

Then, as shown in FIG. 11 (A), the powdery and granular agent (7) is stored in the powdery and granular agent storage chamber (31), and the concentrated fluidized substance (8) is stored in the concentrated fluidized substance storage chamber (32). ) Is stored in the state before taking, when taking, by operating the traction tool (68) to move the partition plug (65) to the large-diameter portion (63) side to remove the powdery granular agent (7). Collected and mixed with the thick fluid substance (8),
After connecting the partition plug (65) and the push plug (66) as shown in FIG. 1 (B), remove the lid sheet (69), push the piston member (67) and push the push plug (66) toward the distal end. By moving
As shown in FIG. 11 (C), the mixture in the powdery and granular agent accommodating chamber (31) and the thick fluid substance accommodating chamber (32) is extruded from the outlet (10). In addition, compartment plug (6
5) and the traction tool (68) constitute the communication path forming means (34),
The push-out operation means (3) is formed by the section stopper (65) and the piston member (67).
5) is configured.

Next, the configuration shown in FIG. 11 will be described. The towing device (68) is a string (70) and a pulling device (71) like Tegus
One end of the string (70) is fixed to the rear end side of the partition plug (65), and the other end is inserted through the insertion hole (73) of the push plug (66).
Exposed to the outside through the other end of the handle (71)
Is attached. The acupressure part (78) of the piston member (67) is provided with a pulling tool locking part (72) for holding the pulling tool (71) in a pulled state, and a string is used when the piston member (67) is pressed. The pull handle (71) can be fixed with the (70) pulled.

The push-in plug (66) is provided with an insertion hole (73) through which the string (70) is inserted. The insertion hole (73) prevents foreign bacteria from entering the thick fluid substance storage chamber (32). A seal member (74) is provided at a predetermined position of (73). By pulling the string (70) downward, the sealing state of the sealing member (74) is released, but since the string (70) is pulled in only one direction, external germs during taking the concentrated fluid substance storage chamber ( 32) never enter. When the push-in stopper (66) is made of rubber,
The seal member (74) may be unnecessary.

The large-diameter portion (63) has a conical portion (79) smoothly connected to the small-diameter portion (62). The push plug (66) has a protrusion (75) that fits into the conical portion (79) above the large diameter portion (63), and the total volume of the protrusion (75) and the volume of the partition plug (65) is provided. Is the same as the total volume of the particulate agent storage chamber (31) and the conical portion (79), and the shape of the push plug (66) and the partition plug (65) when connected is the powder agent storage chamber (31). ) And the inner shape of the conical portion (79). With this configuration, the powdery and granular agent (7) and the thick fluid substance (8) can be transferred to the cylinder (64).
It can be extruded without leaving inside. In addition, since the cross-sectional area of the large-diameter portion (63) is configured to be larger than the cross-sectional area of the small-diameter portion (62), when the partition plug (65) is moved to the large-diameter portion (63) side, a thick flow The granular agent (7) dropped into the substance storage chamber (32) is stirred with the thick fluid substance (8), and the granular agent (7)
And the thick fluid substance (8) can be automatically mixed. Further, since the distal end side of the partition plug (65) has a conical shape, when the piston member (67) is pushed to push out the thick fluid substance (8), it is distributed in an annular shape in the thick fluid substance storage chamber (32). When the thick fluid substance (8) enters the powder agent storage chamber (31), it is mixed so as to enclose the powder agent (7),
It is possible to promote the mixing of (8) and the granular agent (7).

In the configuration shown in FIG. 11, a piston fixture (76) is provided so that the piston member (67) can maintain a predetermined position on the rear end side before taking, and is accommodated in the piston fixture (76). A case (77) is attached to hold the multi-chamber container (1). In FIG. 11, the partition plug (65)
A seating portion may be provided on the rear end side surface and the front end side surface of the push-in plug (66) by fitting unevenness for connecting the partition plug (65), and the partition plug (65) is connected in an abnormal posture. A guide member for preventing this may be provided. Further, in the configuration shown in FIG. 11, the small-diameter portion (62) and the large-diameter portion (63) are formed of a cylindrical body. However, a small cross-section corresponding to the small-diameter portion (62) is formed using a tubular body having a rectangular cross section. A large cross section corresponding to the area portion and the large diameter portion (63) may be formed.

FIGS. 12A to 12D are schematic longitudinal sectional views showing modifications of the ninth embodiment. Note that, in this modification as well, members that perform the same functions as in the ninth embodiment will be described with the same reference numerals. One feature of this variation is that
The traction tool (68) is composed of a support rod (81) that connects the partition plug (65) and the acupressure part (78) of the piston member (67), and connects the partition plug (65) and the push-in plug (66). That is, the connecting means (82) to be formed is formed on the push plug (66). Further, the configuration shown in FIG. 12 will be described. In this modification, the push-in plug (66) is provided with an insertion hole (83) for the support rod (81) to slide up and down freely,
With the support rod (81) penetrating the insertion hole (83), the partition plug (65) is fixed to the upper end of the support rod (81), and the acupressure part (78) is attached to the lower end of the support rod (81). It has a fixed configuration. In addition, a recess receiving seat (84) into which the lower part of the partition plug (65) fits is formed in the protruding portion (75) of the push plug (66). A locking portion (85) is formed on the lower part of the recess receiving seat (84) and the partition plug (65) by fitting unevenness, and when the push plug (66) and the partition plug (65) are connected, the thick fluid substance (8) The connection state is not released even when a force is applied to push out. In addition,
A seal member (86) is provided at the entrance of the insertion hole (83) of the recessed seat (84) so as to prevent invasion of various bacteria into the inside.

The operation of the modification shown in FIG. 12 will be briefly described. First, as shown in FIG. 12 (A), the granular agent (7) was accommodated in the granular agent storage chamber (31) and the concentrated fluid substance (8) was accommodated in the concentrated fluid substance accommodation chamber (32). When taking from the state before taking, the acupressure part (78) of the piston member (67) is pulled downward, and the partition plug (65) is moved to the recess receiving seat (84) side of the push-in plug (66). Thus, the granular agent (7) is collected and mixed with the thick fluid substance (8). And FIG.
As shown in (B), the partition plug (6
After connecting the push plug (66) with the push plug (66), the lid sheet (69) is removed, the acupressure part (78) is pushed in, and the connected push plug (66) is pressed.
Is moved to the distal end side, as shown in FIG. 12 (C), the granular agent storage chamber (31) and the thick fluid substance storage chamber (32)
The mixture inside is pushed out from the outlet (10).

FIG. 12 (D) shows that the acupressure part (78) is strongly pushed from the state shown in FIG. 12 (C) so that the connection between the partition plug (65) and the push plug (66) is released. Thereby, the mixture remaining in the powdery and granular agent storage chamber (31) is configured to be completely extruded, and the state where the connected state is maintained and the connection is released according to the degree of the pressing force of the acupressure part (78) This can be implemented by configuring the locking portion (85) so as to take a state. As described above, according to the configurations of the seventh to ninth embodiments illustrated in FIGS. 7 to 12, there is an advantage that an operation of removing and mixing the powdery and granular agents and an operation of removing a cap and the like are not required. Yes, it can be made of the same material such as resin as required, and a multi-chamber container excellent in disposability and safety can be provided.

[0060]

Since the present invention is constructed and operates as described above, it has the following effects.

(A) Since the thick fluid substance prepared in advance is housed in the storage chamber, when taking it, it is sufficient to simply connect the respective storage chambers and mix the thick fluid substance and the powdery granule,
It can be taken with a very simple operation. In addition, the powdery and granular preparations can be easily swallowed by the flow of the thickened liquid substance when taken, and the powdered and granular preparations are wrapped in the thick liquid substance and can be taken deliciously without feeling the bitterness of the medicinal ingredient, etc. The resistance can be greatly reduced.

(B) Since the granular agent and the thick fluid substance are partitioned and housed in different storage chambers, respectively, the granular agent and the thick fluid substance may be decomposed during storage due to decomposition by moisture contained in the thick fluid substance. Without being affected, the medicinal properties and the like of the powdery agent can be favorably maintained.

(C) Since a single dose of the granular material is accommodated in the accommodation room, a predetermined amount of the granular material can be taken without fail, and the dose does not vary.

(D) When the particle size of the powdery granule is 400 μm or less, the powdery granule is well surrounded by the thick fluid substance and does not give a rough feeling in the mouth of the user.
The patient's resistance to taking the drug can be further reduced.

[Brief description of the drawings]

FIG. 1 is a partially cutaway perspective view of a multi-chamber container containing a thick fluid substance and a particulate agent, showing a first embodiment of the present invention.

FIG. 2 is a partially broken front view showing a second embodiment.

FIG. 3 is a longitudinal sectional front view showing a third embodiment.

FIG. 4 is a perspective view showing a fourth embodiment.

FIG. 5 is a longitudinal sectional front view showing a fifth embodiment.

FIG. 6A is a vertical sectional front view showing a sixth embodiment, and FIG. 6B is a plan view of a sealing material.

7 (A), 7 (B) and 7 (C) are longitudinal sectional views each showing a configuration of a multi-chamber type container according to a seventh embodiment of the present invention.

FIGS. 8A and 8B are diagrams showing other examples of the configuration of the protruding tool.

FIGS. 9A and 9B are diagrams each showing another configuration example of the protruding tool.

FIG. 10 is a view showing a configuration of a multi-chamber type container according to an eighth embodiment of the present invention. FIG. 10 (A) is a schematic cutaway perspective view, and FIGS. It is a schematic diagram for explaining operation.

FIGS. 11A, 11B, and 11C are schematic vertical sectional views each showing a configuration of a multi-chamber container showing a ninth embodiment.

FIGS. 12A to 12D are schematic longitudinal sectional views showing modified examples of the ninth embodiment.

FIG. 13 is a vertical sectional front view showing an application example of the sixth embodiment.

[Explanation of symbols]

1 ... double-chamber container 5 ... accommodation room (upper accommodation room; first accommodation room; tip-side accommodation room;
Fine granule storage room), 6 ... storage room (lower storage room; second storage room; rear end storage room), 6a ... storage room (front end jelly storage room), 6b ... storage room (rear end side jelly) (Accommodation room), 7: powder and granule (fine granule), 8: thick fluid substance (jelly), 10: outlet.

Claims (3)

[Claims] 1. A storage chamber (5.6) in which a powdery granule (7) and a thick fluid substance (8) prepared in advance are partitioned from each other.
6a ・ 6b), and each container (5 ・ 6.6 ・ 6a ・ 6b) is communicated with each other immediately before ingestion to assemble the granular agent (7) and the thick fluid substance (8) and mix them A powdery and granular agent which is used in combination with a thick fluid substance, characterized in that it is constituted so as to be able to be taken. 2. The powdery / granular agent used in combination with the thick fluid substance according to claim 1, wherein the particle diameter of the powdery / granular agent (7) is 400 μ or less. 3. A plurality of storage chambers (5.6.6a.6b) are partitioned so as to be able to communicate with each other, and a powdery or granular agent (7) is sealed and stored in a part of the storage chambers (5) and other storage chambers are sealed. The thick fluid substance (8) is sealed and housed in the chamber (6.6a, 6b), and the respective housing chambers (5.6, 6a, 6b) are communicated with each other based on an operation from the outside, so that the powdery and granular agent (7) And concentrated fluid substance (8) are collected and mixed, and then placed in one of the accommodation rooms (5.6.6a).
-A multi-chamber container containing a thick fluid substance and a particulate agent, wherein the mixture is configured to be able to be taken out from the outlet (10) provided in 6b).