EP2401278A4 - Procédé amélioré pour la préparation d'antibiotique à base de carbapenème - Google Patents
Procédé amélioré pour la préparation d'antibiotique à base de carbapenèmeInfo
- Publication number
- EP2401278A4 EP2401278A4 EP10745866A EP10745866A EP2401278A4 EP 2401278 A4 EP2401278 A4 EP 2401278A4 EP 10745866 A EP10745866 A EP 10745866A EP 10745866 A EP10745866 A EP 10745866A EP 2401278 A4 EP2401278 A4 EP 2401278A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- preparation
- improved process
- carbapenem antibiotic
- carbapenem
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000003115 biocidal effect Effects 0.000 title 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN424CH2009 | 2009-02-26 | ||
PCT/IB2010/000372 WO2010097686A1 (fr) | 2009-02-26 | 2010-02-25 | Procédé amélioré pour la préparation d'antibiotique à base de carbapenème |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2401278A1 EP2401278A1 (fr) | 2012-01-04 |
EP2401278A4 true EP2401278A4 (fr) | 2012-07-04 |
Family
ID=42665048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP10745866A Withdrawn EP2401278A4 (fr) | 2009-02-26 | 2010-02-25 | Procédé amélioré pour la préparation d'antibiotique à base de carbapenème |
Country Status (3)
Country | Link |
---|---|
US (1) | US20120035357A1 (fr) |
EP (1) | EP2401278A4 (fr) |
WO (1) | WO2010097686A1 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3375084B2 (ja) | 2000-03-31 | 2003-02-10 | 塩野義製薬株式会社 | ピロリジルチオカルバペネム誘導体の新型結晶 |
US8729260B2 (en) * | 2010-05-19 | 2014-05-20 | Savior Lifetec Corporation | Process for the preparation of carbapenem using cabapenem intermediates and recovery of cabapenem |
WO2012114280A1 (fr) * | 2011-02-23 | 2012-08-30 | Orchid Chemicals And Pharmaceuticals Limited | Procédé amélioré de préparation de dérivés de pyrrolidine thiol utiles dans la synthèse des composés de carbapénème |
CN102452969B (zh) * | 2011-08-19 | 2013-11-27 | 深圳市海滨制药有限公司 | 一种多尼培南侧链化合物及其制备方法和用途 |
CN102702201B (zh) * | 2012-03-26 | 2013-12-25 | 深圳市海滨制药有限公司 | 一种多尼培南中间体化合物、其制备方法和用途以及多尼培南的制备方法 |
WO2014088315A1 (fr) * | 2012-12-04 | 2014-06-12 | 주식회사 대웅제약 | Monohydrate de doripénème cristallin et son procédé de préparation |
CN105439931B (zh) * | 2015-11-21 | 2018-06-22 | 河南海利华生物科技发展有限公司 | 一种多尼培南药物中间体多尼培南侧链的纯化方法 |
CN106565549A (zh) * | 2016-11-08 | 2017-04-19 | 南安创友日化有限公司 | 一种合成n‑烷基对甲苯磺酰胺的方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006049113A1 (fr) * | 2004-11-01 | 2006-05-11 | Shionogi & Co., Ltd. | Intermédiaire de synthèse d’un carbapénème et méthode de synthèse dudit intermédiaire |
EP1852436A1 (fr) * | 2005-02-15 | 2007-11-07 | Shionogi Co., Ltd. | Procede de production d'un derive de carbapeneme et d'un intermediaire cristallin de celui-ci |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69528166T2 (de) * | 1994-05-02 | 2003-04-30 | Shionogi & Co., Ltd. | Kristalline pyrrolidylthiocarbapenem derivate, lyophilisierste präparationen dieser kristalle und verfahren zu deren herstellung |
WO2006117763A2 (fr) * | 2005-05-03 | 2006-11-09 | Ranbaxy Laboratories Limited | Procede de preparation de doripeneme |
WO2007029084A2 (fr) * | 2005-09-05 | 2007-03-15 | Ranbaxy Laboratories Limited | Composes de carpapenem: operation amelioree de fabrication |
-
2010
- 2010-02-25 EP EP10745866A patent/EP2401278A4/fr not_active Withdrawn
- 2010-02-25 WO PCT/IB2010/000372 patent/WO2010097686A1/fr active Application Filing
- 2010-02-25 US US13/146,161 patent/US20120035357A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006049113A1 (fr) * | 2004-11-01 | 2006-05-11 | Shionogi & Co., Ltd. | Intermédiaire de synthèse d’un carbapénème et méthode de synthèse dudit intermédiaire |
EP1852436A1 (fr) * | 2005-02-15 | 2007-11-07 | Shionogi Co., Ltd. | Procede de production d'un derive de carbapeneme et d'un intermediaire cristallin de celui-ci |
Also Published As
Publication number | Publication date |
---|---|
EP2401278A1 (fr) | 2012-01-04 |
US20120035357A1 (en) | 2012-02-09 |
WO2010097686A1 (fr) | 2010-09-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20110817 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR |
|
DAX | Request for extension of the european patent (deleted) | ||
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07D 477/06 20060101AFI20120524BHEP Ipc: C07D 207/08 20060101ALI20120524BHEP |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20120604 |
|
17Q | First examination report despatched |
Effective date: 20130411 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20130822 |