EP2391328A1 - Blood plasma container - Google Patents
Blood plasma containerInfo
- Publication number
- EP2391328A1 EP2391328A1 EP09752117A EP09752117A EP2391328A1 EP 2391328 A1 EP2391328 A1 EP 2391328A1 EP 09752117 A EP09752117 A EP 09752117A EP 09752117 A EP09752117 A EP 09752117A EP 2391328 A1 EP2391328 A1 EP 2391328A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- blood plasma
- container
- plasma container
- neck
- plasma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1412—Containers with closing means, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1475—Inlet or outlet ports
- A61J1/1487—Inlet or outlet ports with friction fit, e.g. connecting tubes directly to a protruding port
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
- A61J1/12—Bag-type containers with means for holding samples of contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
Definitions
- the invention relates to a blood plasma container made of plastic with a body, on one side of a neck is provided, wherein the body in horizontal section has a substantially rectangular cross-section.
- Blood in the body of humans fulfills a variety of functions. It takes on, for example, a transport function, because the circulation of the blood numerous dissolved substances and heat are transported from the place of their production or absorption to the place of their degradation or excretion, a respiratory function, a nutrient and rinse function and a defense function.
- the blood consists of cells, the red blood cells (erythrocytes), the white blood cells (leucocytes) and the platelets and surrounding fluid, the blood plasma (Deetjen / Speckmann "Physiology” Verlag Urban & Schwarzenberg, 1992, p 261)
- the plasma is a liquid rich in proteins, the composition of which largely corresponds to the interstitial fluid (Deetjen / Speckmann, op. cit., p. 265) .These are usually used for the collection of blood plasma bottles.
- Blood plasma containers of the aforementioned type are known per se (cf .. DE 20 2007 012 912 U1). They offer the possibility to store and transport recovered blood plasma reliably and space-saving. In addition, they have dimensions corresponding to those of plasma bags, so that the blood plasma containers are compatible with the transport and storage facilities provided for plasma bags.
- the known blood plasma containers fulfill all requirements placed on them.
- One disadvantage of using the known blood plasma containers is their behavior in the frozen state of the plasma. It has been found that during the freezing process, the containers Extend 1/7 of its volume. This leads to a bulging of the container, so that the given space-saving arrangement of a plurality of plasma containers is no longer guaranteed.
- the sample collection tubes required for blood plasma collection are not easy to handle. As a result, the tubes are attached to the containers in the known blood plasma containers with rubber bands, whereby the handling and storage or the transport of the containers is adversely affected.
- the invention aims to remedy this situation.
- the invention has for its object to improve blood plasma containers.
- this object is achieved, on the one hand, by providing a central web inside the body.
- the risk of buckling of the container during the freezing process of the blood plasma is prevented.
- the inventive blood plasma container retains its original shape, so that both storage and transport of the blood plasma container according to the invention in the known devices is possible.
- the object is achieved on the other hand according to the invention in that at least one holder for sampling tube is arranged.
- This provides the ability to attach the blood plasma sample collection tubes directly to the container without the need for the use of rubber bands or the like.
- the use of the brackets offers the possibility of attaching the sampling tube directly to the container while still using the known storage and transport facilities.
- the brackets are provided in the region of the central web.
- the holders consist of recesses, which essentially reproduce the contour of the sampling tube. This makes it possible to introduce the sampling tube into the wells and to transport with the containers without the aid of other means. Because the Tubes are inserted into the wells, no supernatant is caused by the tubes, so that the handling is not adversely affected by the entrainment of the tubes.
- FIG. 1 shows the view of a blood plasma container with closure cap, extraction and ventilation and Verprobungsaku
- FIG. 2 is a plan view of the blood plasma container shown in FIG. 1;
- FIG. FIG. 3 shows the plan view of the blood plasma container with twisted closure cap shown in FIG. 1;
- FIG. 4 shows the view of a blood plasma container with a closure cap, an extraction and aeration and testing unit in a different embodiment
- Fig. 5 is a plan view of the blood plasma container shown in Fig. 4; 6 shows the plan view of the blood plasma container with twisted closure cap shown in FIG. 4; 7 shows the view of a blood plasma container with a closure cap, an extraction and aeration and testing unit in another embodiment;
- FIG. 8 is a plan view of the blood plasma container shown in Fig. 7;
- FIG. 9 is a plan view of the twisted closure blood plasma container shown in FIG. 7;
- Fig. 10 is a bottom view of the blood plasma container shown in Fig. 7; 11 shows the view of a blood plasma container with closure cap, extraction and ventilation and Verprobungshim in a further embodiment.
- Fig. 12 is a plan view of the blood plasma container shown in Fig. 11;
- Fig. 13 is a plan view of the illustrated in Figure 11 blood plasma container with twisted cap and Fig. 14 is a bottom view of the blood plasma container shown in FIG.
- the selected as embodiment blood plasma container is made of plastic.
- the plastic is polyethylene, preferably high-density polyethylene (HDPE). But also medium density polyethylene (MDPE) or low density polyethylene (LDPE) can be used. Important in the choice of material is in addition to meeting the hygienic requirements essentially sufficient stability of the container even in the frozen state of the plasma.
- the container consists of a body 1 which has a substantially rectangular cross section in horizontal section. He has a neck 2 at one end. The neck 2 is closed with a container neck surface 3. The container neck surface 3 is not detachably provided on the neck 2. Bottle 1, neck 2 and container neck surface 3 are formed in one piece and are produced in one production step.
- the body 1 has a thickness which corresponds to about one third of the diameter of known plasma bottles.
- the dimensions of the container according to the invention correspond approximately to those of known plasma bags; they therefore have about the same filling volume.
- a middle day 1a is provided inside the body 1.
- the central web 1a extends from the bottom of the body 1 in the direction of the neck 2.
- the central web 1a extends over approximately 70% of the height of the body 1, whereby a gap 1b is formed between the central web 1a and the neck 2.
- the height of the central bar corresponds approximately to a filling level of 650 ml of blood plasma. Since plasma containers are usually filled with 650 to 850 ml of blood plasma, it is ensured in this way that the chambers formed on both sides of the central web 1 a are uniformly filled with blood plasma.
- the central web 1a in principle creates a three-chamber system in the plasma container, namely one chamber on each side of the central tank. web 1a and a chamber above the central web 1a on both sides of the gap 1b. This results in a much improved freezing behavior of the plasma. While the plasma in a webless rectangular container requires a freezing time of about 2 to 2.25 hours, in the case of the container according to the invention under the same basic conditions, only a freezing time of 1.5 to 2 hours is required. Thus, the recovered plasma is much more ready for further processing.
- two holes are provided in the embodiment of Figures 1 to 3, are attached to the nozzle 5.
- the nozzle 5 are not detachable and mounted close to the container neck surface 3.
- devices 5 are provided for connecting hoses.
- the devices 5 are in the embodiment of L-shaped elbows that are not detachably connected to the nozzle 4.
- the hoses are not detachably arranged.
- connection bore 61 faces the neck 2 of the plasma container.
- connection bores 62 and 63 are aligned at right angles to the connection bore 61. They are diametrically opposed. From the connection bores 62 and 63, connections 64 and 65 each extend, which are provided with a right angle and thus open into the connection bore 61.
- a tubular extension piece 66 is additionally provided, which protrudes into the connection bore 61.
- the hoses connected to the devices 5 or the connector 6 are a ventilation hose 7 and a filling hose 8.
- the hoses 7 and 8 are made of plastics that allow sterilization.
- the ventilation and Verismesech includes a Y-piece, which is provided with a shut-off device 91 and a branch 92.
- the shut-off device 91 is designed as a self-sealing filter. This is made of air-permeable, hydrophobic plastic, preferably polyethylene and closes itself when liquid contact independently. As long as the self-sealing filter does not come into contact with liquid, it is permeable to air and filters the air, preventing contamination of the blood plasma with bacteria in the air.
- the branch 92 is adjoined by a coupling connection 10 into which a rubber needle valve 101 is integrated.
- the connection 10 serves to receive a sample tube (not shown) under vacuum.
- a recovery unit is provided at its end facing away from the container. It is provided with a switch 11 to which two tubes 12 and 13 of different lengths are connected.
- Hose 12 has at its end facing away from the switch 11 a receptacle 14 with a protective cap 15. To the receptacle 14, a centrifuge bowl is connected during the dispensing process. At the end of the tube 13 facing away from the switch 11, a piercing spike 16 is arranged, on whose free end a cap 17 can be attached. The insertion mandrel 16 is used for removal from bottles with physiological saline.
- the nozzle 4 and the devices 5 according to the embodiment of Figures 1 to 3 and the connector 6 according to the embodiment of Figures 4 to 6 can be covered with a rotary and cap 18. It is provided with a means for locking on the neck 2 of the container.
- the cap 18 has two slots 181 which extend from their facing and axially in the direction of the container facing away from the end of the cap 18 extend.
- the slots 181 are arranged diametrically opposite each other in the embodiment and are used to pass the tubes 7 and 8.
- the cap 18 is in a position in which the tubes 7 and 8 are passed through the slots 181 unhindered.
- the tubes 7 and 8 are cut off by means of a thermo-tongs and welded.
- the cap 18 is actuated. For this purpose, the cap 18 is rotated. In this case, the free ends of the tubes 7 and 8 are drawn into the cap 18 ( Figures 3 and 6).
- At least one holder 19 for blood plasma sample removal tubes 20 is arranged on the body 1.
- a holder 19 is arranged on each side of the neck 2.
- the brackets 19 are formed in the form of a web 192 and allow a Verclipsen the sampling tube.
- 192 part-circular openings 191 are formed in the webs, whose diameter corresponds to the diameter of the sampling tube.
- the tubes are pressed for fastening in a known manner in the openings 191 and are thereby reliably fixed to the container according to the invention.
- brackets 19 are provided in the region of the central web 1a. They consist of recesses 193, which essentially reproduce the contour of the sampling tube 20.
- the withdrawal tubes 20 can be inserted into the recesses and kept removable therefrom. When inserted, the head of the sampling tube 20 is flush with the bottom of the plasma container.
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE200920001068 DE202009001068U1 (en) | 2009-01-28 | 2009-01-28 | Blood plasma container |
PCT/EP2009/007846 WO2010085990A1 (en) | 2009-01-28 | 2009-11-03 | Blood plasma container |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2391328A1 true EP2391328A1 (en) | 2011-12-07 |
EP2391328B1 EP2391328B1 (en) | 2014-02-26 |
Family
ID=40531065
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP09752117.3A Not-in-force EP2391328B1 (en) | 2009-01-28 | 2009-11-03 | Blood plasma container |
Country Status (4)
Country | Link |
---|---|
US (1) | US20110284413A1 (en) |
EP (1) | EP2391328B1 (en) |
DE (1) | DE202009001068U1 (en) |
WO (1) | WO2010085990A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1397633B1 (en) * | 2010-01-22 | 2013-01-18 | Biomed Device Srl | DEVICE FOR THE CONTAINMENT OF PIASTRINICAL CONCENTRATES AND DEVICE FOR THE PREPARATION OF UNITS FOR THE CONTAINMENT OF PLASTIC PREPARATIONS. |
WO2011142752A1 (en) | 2010-05-12 | 2011-11-17 | Haemonetics Corporation | Blood plasma storage bottle with locking cap |
DE202010012728U1 (en) * | 2010-09-22 | 2011-11-29 | Deutsche Gesellschaft für Humanplasma mbH | Blood plasma collection bottle |
CN102048640B (en) * | 2011-01-28 | 2013-04-24 | 周小君 | Integrated plastic double-color cover with double pipes and double valves for packaging large infusion soft bags and bottles |
DE202011052056U1 (en) * | 2011-11-22 | 2011-12-30 | Deutsche Gesellschaft für Humanplasma mbH | Blood plasma collection bottle |
US11559464B2 (en) | 2016-05-16 | 2023-01-24 | Haemonetics Corporation | Sealer-less plasma bottle and top for same |
US11648179B2 (en) | 2016-05-16 | 2023-05-16 | Haemonetics Corporation | Sealer-less plasma bottle and top for same |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2780225A (en) * | 1953-03-03 | 1957-02-05 | Courtland H Barr Sr | Blood packaging unit |
US2780255A (en) * | 1955-05-05 | 1957-02-05 | Williams & Hussey Machine Corp | Guides for machines having a bed over which stock is fed |
US3079920A (en) * | 1960-07-22 | 1963-03-05 | Baxter Laboratories Inc | Flexible container with integral pilot tube holder |
US3228395A (en) * | 1961-11-10 | 1966-01-11 | Mcgaw Lab Inc | Blood bag transfusion unit with pressure chamber |
US3304977A (en) * | 1965-01-11 | 1967-02-21 | Velikanje Moore & Countryman | Blood container |
GB1216534A (en) * | 1967-03-03 | 1970-12-23 | Braun Internat G M B H B | Improvements in or relating to containers for storing and dispensing medicinal liquids |
US4467588A (en) * | 1982-04-06 | 1984-08-28 | Baxter Travenol Laboratories, Inc. | Separated packaging and sterile processing for liquid-powder mixing |
US5364385A (en) * | 1990-05-09 | 1994-11-15 | Lifesource Advanced Blood Bank Systems, Inc. | Storage bag for blood and blood components |
US5749504A (en) * | 1994-06-09 | 1998-05-12 | Bieker; Michael C. | Blood collection tube holder |
US7225937B2 (en) * | 2003-05-13 | 2007-06-05 | Schroeder Michael D | Package system |
DE202007012912U1 (en) | 2007-09-14 | 2007-12-06 | Heinz Meise Gmbh | Blood plasma container |
-
2009
- 2009-01-28 DE DE200920001068 patent/DE202009001068U1/en not_active Expired - Lifetime
- 2009-11-03 US US13/138,277 patent/US20110284413A1/en not_active Abandoned
- 2009-11-03 EP EP09752117.3A patent/EP2391328B1/en not_active Not-in-force
- 2009-11-03 WO PCT/EP2009/007846 patent/WO2010085990A1/en active Application Filing
Non-Patent Citations (1)
Title |
---|
See references of WO2010085990A1 * |
Also Published As
Publication number | Publication date |
---|---|
US20110284413A1 (en) | 2011-11-24 |
WO2010085990A1 (en) | 2010-08-05 |
DE202009001068U1 (en) | 2009-04-09 |
EP2391328B1 (en) | 2014-02-26 |
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