EP2382007A1 - Ensemble neurostimulateur électrique - Google Patents

Ensemble neurostimulateur électrique

Info

Publication number
EP2382007A1
EP2382007A1 EP10735420A EP10735420A EP2382007A1 EP 2382007 A1 EP2382007 A1 EP 2382007A1 EP 10735420 A EP10735420 A EP 10735420A EP 10735420 A EP10735420 A EP 10735420A EP 2382007 A1 EP2382007 A1 EP 2382007A1
Authority
EP
European Patent Office
Prior art keywords
coil
cage
container
electrode assembly
assembly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP10735420A
Other languages
German (de)
English (en)
Inventor
Janusz A. Kuzma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurostimulation Devices And Technology Pty Ltd
Original Assignee
Neurostimulation Devices And Technology Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2009900289A external-priority patent/AU2009900289A0/en
Application filed by Neurostimulation Devices And Technology Pty Ltd filed Critical Neurostimulation Devices And Technology Pty Ltd
Publication of EP2382007A1 publication Critical patent/EP2382007A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/375—Constructional arrangements, e.g. casings
    • A61N1/3752—Details of casing-lead connections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36036—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the outer, middle or inner ear
    • A61N1/36038—Cochlear stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • A61N1/37223—Circuits for electromagnetic coupling
    • A61N1/37229—Shape or location of the implanted or external antenna

Definitions

  • the present invention relates to generally to the field of medical devices, with embodiments directed towards the field of implantable electrical neuro stimulators.
  • embodiments include but are not limited to cochlear implants, implantable hearing aids, deep brain stimulators and pain control devices, as well as constituent components of such devices, methods for their manufacture, and methods for their use.
  • neurostimulator design for example in the context of cochlear implants
  • reliability requirements push the limits of manufacturing technologies. Examples of such devices are described in US Patent No. 5,105,811 and US Patent No. 5,562,7101.
  • Most neurostimulator designs are based on the concept of creating a hermetic metal or ceramic capsule equipped with a number of hermetic electrical feedthroughs for transferring electrical signals in and out between the internal space of the capsule and the surrounding environment.
  • a main capsule is made from biocompatible metal like titanium, and a multi-contact feedthrough provides connection between internal electronic circuitry, a stimulating lead, and connection to an external antenna loop (or loops) for data and power transfer.
  • One embodiment provides an implantable device including: a first portion formed of a flexible non-conductive material, the first portion containing one or more conductive coils; a second portion coupled to the first portion, the second portion including a rigid container that defines a cavity therein for maintaining processing circuitry; and an electrode assembly coupled to the second portion, the electrode assembly including an elongate body that extends away from the first and second portions, wherein the electrode assembly is coupled to the processing circuitry.
  • One embodiment provides a device wherein the second portion includes a base and a top separated by a sidewall, and wherein a plurality of feedthroughs are formed through the sidewall for allowing the passage of wires between the first and second portions.
  • One embodiment provides a device wherein the first portion contacts with outer portions of the feedthroughs.
  • One embodiment provides a device including a rigid cage that is fixedly mounted to the second portion, and that includes formations for mechanically anchoring the first portion to the second portion.
  • One embodiment provides a device wherein the cage is welded to the second portion.
  • One embodiment provides a device wherein the cage is integrally formed with the second portion.
  • One embodiment provides a device wherein the cage includes an array of cage members positioned to define windows that provide for the anchoring of the first portion to the cage.
  • One embodiment provides a device wherein the first portion is formed by a molding process whereby a moldable material that substantially defines the first portion flows through the windows and into the cage thereby to anchor the first portion with respect to the second portion.
  • One embodiment provides a device wherein the electrode assembly is coupled to the processing circuitry via the feedthroughs.
  • One embodiment provides a device wherein the rigid container is configured for protecting a point of connection, on the underside of the device, between the electrode assembly and the second portion, from downward impact.
  • One embodiment provides a device wherein the electrode assembly is mounted to the second portion at a location at or adjacent a lower surface of the second portion, wherein the location is inwardly spaced apart from the periphery of the second portion.
  • One embodiment provides a device wherein the location is substantially central with respect to the lower surface of the second portion.
  • One embodiment provides a device wherein the rigid container is metallic, and wherein the electrode assembly is electrically insulated with respect to the rigid container.
  • One embodiment provides a device including a power transfer loop including: a multi- stranded wire coil; and a lumen surrounding the coil, wherein the lumen is formed from a resilient plastic tube.
  • One embodiment provides a device wherein the rigid container is metallic, and wherein the ground electrode is mounted in a recess formed in an external surface of the rigid container.
  • One embodiment provides a method for forming an implantable device, the method including: providing a rigid container that defines a cavity therein for maintaining processing circuitry, wherein the rigid container includes a feedthrough assembly for allowing the passage of wires between the processing circuitry and components external of the container, wherein the feedthrough assembly is protected by a cage; connecting the processing components to components external of the container, including an electrode assembly and a coil, by way of the feedthrough assembly; using a moulding process to define a flexible flap for containing the coil, wherein the flexible flap extends into the cage thereby to mechanically connect the flap to the container.
  • an implantable device including: a rigid container that defines a cavity therein for maintaining processing circuitry, wherein the rigid container includes a feedthrough assembly for allowing the passage of wires between the processing circuitry and components external of the container, wherein the feedthrough assembly is protected by a cage; components external of the container that are coupled to the processing components by way of the feedthrough assembly, wherein the components external of the container include including an electrode assembly and a coil,; flexible flap for containing the coil, wherein the flexible flap is formed by a mounding process and extends into the cage thereby to mechanically connect the flap to the container.
  • One embodiment provides a power transfer loop for an implantable device, the power transfer loop including: a multi- stranded wire coil; and a lumen surrounding the coil, wherein the lumen is formed from a resilient plastic tube.
  • One embodiment provides a method for forming a power transfer loop for an implantable device, the method including: providing a multi- stranded wire coil; and encasing the coil within a resilient plastic lumen thereby to define an encased coil; heating the encased coil to above a predetermined temperature; forming the encased coil to a desired shape; and allowing the encased coil to cool, such that it sets in the desired shape.
  • any of the claimed embodiments can be used in any combination.
  • some of the embodiments are described herein as a method or combination of elements of a method that can be implemented by a processor of a computer system or by other means of carrying out the function.
  • a processor with the necessary instructions for carrying out such a method or element of a method forms a means for carrying out the method or element of a method.
  • an element described herein of an apparatus embodiment is an example of a means for carrying out the function performed by the element for the purpose of carrying out the invention.
  • any one of the terms “comprising”, “comprised of, or “which comprises” is an open term that means including at least the elements/features that follow, but not excluding others.
  • the term “comprising”, when used in the claims, should not be interpreted as being limitative to the means or elements or steps listed thereafter.
  • the scope of the expression a device comprising A and B should not be limited to devices consisting only of elements A and B.
  • Any one of the terms “including”, “which includes” or “that includes” as used herein is also an open term that also means including at least the elements/features that follow the term, but not excluding others.
  • “including” is synonymous with and means the same as “comprising”.
  • Coupled when used herein, should not be interpreted as being limitative to direct connections only.
  • the terms “coupled” and “connected,” along with their derivatives, may be used.
  • the scope of the expression a “device A coupled to a device B” should not be limited to devices or systems wherein an output of device A is directly connected to an input of device B. It means that there exists a path between an output of A and an input of B which may be a path including other devices or means.
  • Coupled may mean that two or more elements are either in direct physical or electrical contact, or that two or more elements are not in direct contact with each other but yet still co-operate or interact with each other.
  • FIG. IA provides a front perspective view of a device according to one embodiment.
  • FIG. IB provides a rear perspective view of the device of FIG. IA.
  • FIG. 2 provides a partially cut-away perspective view of a shell component of the device of FIG. IA, showing an array of hermetic electrical feedthroughs.
  • FIG. 3A provides an exploded front perspective view of the device of FIG. IA.
  • FIG. 3B provides an exploded front perspective view of the device of FIG. IA.
  • FIG. 4 shows the device of FIG. IA in a partially constructed state.
  • FIG. 5A provides a top view of the device of FIG. IA.
  • FIG. 5B provides a cross-sectional view along the line B-B of FIG. 5A.
  • FIG. 5C provides a more detailed view of a region of FIG. 5B, showing connection Ia wires to feedthroughs.
  • FIG. 6A provides a perspective view of an electrode assembly according to one embodiment.
  • FIG. 6B provides a perspective sectional view of the electrode assembly shown in
  • FIG. 6A is a diagrammatic representation of FIG. 6A.
  • FIGS. 7A & 7B demonstrate construction of a low impedance coil according to one embodiment.
  • FIG. 8 provides a perspective view of a component according to one embodiment, this component providing a coil flap for the device of FIG. IA.
  • embodiments include but are not limited to cochlear implants, implantable hearing aids, deep brain stimulators and pain control devices, as well as constituent components of such devices, methods for their manufacture, and methods for their use.
  • embodiments are described particularly by reference to exemplary cochlear implants, although that should not be regarded as necessarily limiting on the underlying concepts.
  • Embodiments of the present invention are directed to improving design, reliability and other such factors, in a manner especially suitable for a stimulator that is to be implanted on the surface of the human skull.
  • the best examples of such devices are cochlear implants, implantable hearing aids, deep brain stimulators and peripheral nerve stimulators like migraine suppression devices.
  • the present inventor has observed various issues which still present a significant challenge and have not necessarily been sufficiently addressed by existing designs or technologies. These include: • Creating an acceptable, low profile device (but still with sufficient internal space to accommodate electronics), retained in a stable position and resilient to loss of hermeticity if exposed to a mechanical impact, providing sufficient protection to internal circuitry.
  • Design and manufacturing technology described below provides, for some embodiments, an effective solution in the context of these challenges, providing a highly reliable device with shape suitable for placement at head level of adults and small children.
  • Embodiments described herein described herein are directed to a design and manufacturing technique of implantable, hermetic package for electrical neuro stimulators with RF power and data communication functionalities. Embodiments are described by reference to a hermetic package-type device in the form of a device 10 shown in the various figures. Device 10 is particularly suitable for cochlear implants, implantable hearing aids and other head- implanted neuro stimulators.
  • device 10 is a substantially planar device visually/notionally defined by three segments: a rigid hermetic container 11, which contains processing components; a flexible flap 70, which contains embedded telemetry coils; and an electrode assembly 20, which is configured for neuro stimulation.
  • a rigid hermetic container 11 which contains processing components
  • a flexible flap 70 which contains embedded telemetry coils
  • an electrode assembly 20 which is configured for neuro stimulation.
  • FIG. 11 details an exemplary method for forming device 10. This is provided substantially as an introduction to the various components of device 10, and should not be necessarily regarded as limiting from a construction method perspective. Furthermore, various steps may be performed in sequences other than described herein.
  • Figs 3A and 3B show exploded view of the device 10. Both figures illustrate reference positioning of all main components and illustrate key assembly processes.
  • Container 11 defines a cavity for containing processing equipment (for example one or more printed circuit boards) and the like for providing neuro stimulation functionalities to device 10. The nature of this processing equipment is generally ignored for the purpose of the present disclosure, and varies depending on the specific application.
  • Container 11 presently includes an upper shell 100 and a lower shell 120 which are welded together to define a cavity therebetween.
  • the upper shell is acts substantially as an open container having sidewalls, whilst the lower shell is substantially planar and acts as a lid for sealing the container of the upper shell.
  • alternate constructions are used to define the metal container.
  • This hermetic metal container performs the role of protecting sensitive electronic circuitry contained within hermetically sealed internal space from the destructive effect of bodily fluids, and mechanically guarding fragile wiring connections to the feedthrough outputs.
  • Shell 100 is preferably machined from solid piece of metal like titanium or its alloy. Tapered edges of shell 100 give the device an ergonomic profile by blending its contour underneath the skin, and at the same time make the construction stiff and resilient to deformation by an external blow to the head.
  • Container 11 includes a sidewall equipped with an array of hermetic electrical feedthroughs 101, as best shown in FIG. 2, collectively referred to as feedthrough assembly 15.
  • the feedthrough assembly is defined by a plurality of apertures, in the form of feedthroughs 101, which extend through a sidewall of container 11 and into flap 70. Positioning of the feedthroughs 101 on the side wall of the shell 100 makes it possible to create a large open space 105 within the metal shell to accommodate internal circuitry, whilst containing the overall thickness of the device.
  • Feedthrough assembly 15 allows for the wiring of components within the cavity to components outside of the cavity (for example to telemetry coils and the electrode assembly).
  • This construction allows the side section containing sensitive feedthroughs 100 to be much thicker and more resilient to damage without increasing the overall thickness of the device. Assembly begins with placement and connection of the electronic circuits to the internal feedthrough outputs of feedthroughs 101. Container 11 is sealed by hermetically welding upper shell 100 to lower shell 120 about their respective edges.
  • a recess 103 is machined in the top of shell 100 to accommodate, in a stable position, ground electrode assembly 30.
  • Electrode assembly 30 is adhesively fixed to the bottom of the recess and optionally held in place by a separate metal ring welded to the edge of the recess. This is advantageous in the sense that the ground electrode assembly 30 in use directly faces the skin overlaying the implant which provides limited protection from external forces.
  • ground electrode 30 is fixed in recess 103, and connected to its respective feedthrough (or feedthroughs).
  • the ground electrode assembly 30 is fixed in the shell recess 103 and connecting strip 33 is welded to a corresponding one of feedthroughs 101.
  • power coil 50 and data coil 60 are connected to a corresponding one of feedthroughs 101.
  • Feedthrough cage 90 then placed over feedthrough array 101 (and components connected to it), and spot welded to the edge of front recess of shell 100, as shown in the figures.
  • Cage 90 includes a protective upper surface 91, which protects the delicate wire exit points of feedthrough assembly 15 by providing a rigid overlying cover.
  • Cage 90 includes an array of cage members, presently being a lower horizontal member connected to upper surface 91 by a plurality of vertical members, thereby to define windows 92. These allow anchoring of flap 70, as discussed further below.
  • a bottom cover 110 is placed over electrode assembly 20 and spot welded to the shell 120. The nature of cover 110 provides various advantageous functionalities, which are discussed further below.
  • the whole assembly shown in Fig. 4 including a magnet 80, is placed inside a moulding die, and liquid polymer (such as silastic or the like) is injected to fill mould cavity to form flap 70.
  • the flexible flap 70 keeps telemetry coils 50, 60 and magnet assembly 80. in stable defined position.
  • a very important detail of this process is that the liquid polymer flows through the windows at the front of cage 90 to create a strong mechanical bond between the flap and the hermetic case assembly of container 11. That is, the liquid polymer forming flap 70 flows into cage 90, thereby to anchor flap 70 to container 11. Additionally, the polymer flows around feedthrough assembly 15, thereby protecting wiring, and partially into the feedthroughs 101, thereby assisting in hermetic sealing.
  • Figs 5A, 5B and 5C show in more detail the final positioning of all components at final assembly stage and forming of the antenna coil 70.
  • electrode assembly wiring 21 connection to feedthroughs 101 and mechanical engagement of flap 70 with cage 90.
  • cover 110 overhangs edge of shell 100, creating free passage for wires 21 to feedthroughs 101. This forms effective mechanical protection for wires 21 which are inherently fragile.
  • well pronounced cylindrical shape of cover 110 performs a fixation role for the implant when placed in skull drillout.
  • a particularly important step in the assembly of device 10 is a selective overmoulding of the complete assembly to form coil flap 70 as shown in FIG. 8.
  • This process involves the entire partially constructed implant assembly being placed inside cavity of moulding tool. Liquid polymer is then injected into the tool. The tool is shaped such that the polymer forms antenna flap 70; fills space within cage 90 through windows 92; and through overhang of cover 110, fills that cavity, fixing lead within.
  • windows 92 in the cage 90 is particularly significant in the context of this embodiment. These perforations provide a very efficient anchorage of antenna flap 70 to the case assembly, and thereby eliminate a need for traditional bulky external overmoulding of shell 100 to provide sufficient mechanical retention of the antenna flap. Such overmoulding would also significantly increase dimensions of the implant.
  • FIG. 5 shows in detail design principles of connecting wires 21 to feedthroughs 101.
  • the end of the lead assembly is placed close to the edge of the shell containing array of feedthroughs 101.
  • the wires 21 are transferred to the feedthroughs and fused to corresponding feedthrough pins.
  • a protective metal cover 110 is placed over the end of the lead and spot welded to the bottom cover 120.
  • electrode assembly 20 egresses from container 11 via cover 110, which is positioned on the underside of device 10 away from the device's periphery.
  • cover 110 provides an electrode connection position protected from mechanical stresses transmitted through overlaying layer of skin by overhanging portions of container 11. This differs from (and significantly improves upon) known devices, where the electrode assembly typically egresses at the periphery.
  • Bottom cover 110 is presently configured for use as device fixation stump embedded securely within a drillout of skull bone. This allows for reliably positioning of device 10 with respect to the skull. Additionally, cover 110 guides the lead of electrode assembly 20 into the middle ear cavity. A further important element of this embodiment is that cover 110 overhangs the edge of shell 100, creating free passage for the wires 21 to the feedthroughs 101. This forms effective mechanical protection for the wires 21, which are inherently fragile.
  • FIGS. 6 A & 6B An approach for construction of the ground electrode assembly 30 according to one embodiment is illustrated in FIGS. 6 A & 6B.
  • round metal disk 31 preferably made form platinum foil is moulded within plastic form 32 preferably "Peek".
  • Peek is a preferred material due to its superior mechanical strength (much higher than the gold used for coil construction), excellent insulation characteristics, and biocompatibility.
  • the top surface of the platinum disk 31 remains exposed, as well as connecting strip 33.
  • the edges and bottom of the disk are insulated to prevent shorting to the shell 100 upon assembly of device 10. This results in a particularly advantageous electrode construction compared to that which is known in the art.
  • FIGS. 7A & 7B demonstrate an approach for construction of a low impedance coil according to one embodiment. This is particularly suitable for power transfer coil 50.
  • the best performance can be achieved with single or multi-turn antenna coils made from low impedance biocompatible metal like pure gold.
  • gold has excellent electrical characteristics, its mechanical strength is very poor. Under mechanical stress due to movement or impact, it is very easily fractured even in a flexible, multi- stranded configuration.
  • Embodiments of the present invention propose a solution including the placement of multi- stranded coil wire within lumen of mechanically resilient plastic tube 51.
  • the preferred choice of material for tube 51 is "Peek" which has superior mechanical properties that provide effective protection for the contained wire from impact or tensile stress. However, other materials may be used.
  • the wire 52 and tube 51 assembly shown in FIG. 7 A is formed into a desired shape, for example that shown in FIG. 7B. This is preferable accomplished within the cavity of a holding tool by heating the assembly to about 300°C, followed by cooling. This process substantially permanently remoulds the shape of whole coil assembly 50.
  • the data coil 60 is optionally constructed by similar means, or alternately be formed from a more resilient metal such as stainless steel. In the case of such more resilient materials, the use of a polymer lumen may not be necessary.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Otolaryngology (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Electromagnetism (AREA)
  • Prostheses (AREA)
  • Electrotherapy Devices (AREA)

Abstract

L'invention porte sur une technologie se rapportant au domaine des neurostimulateurs électriques implantables. Par exemple, les modes de réalisation de l'invention comprennent, mais sans s'y limiter, des implants cochléaires, des aides auditives implantables, des stimulateurs cérébraux profonds et des dispositifs de maîtrise de la douleur, ainsi que des composants constituant de tels dispositifs, des procédés de fabrication et des procédés d'utilisation. Pour les présents objectifs, des modes de réalisation sont décrits en faisant particulièrement référence à des exemples d'implants cochléaires, bien que ceux-ci ne doivent pas être considérés comme limitant nécessairement les concepts sous-jacents.
EP10735420A 2009-01-27 2010-01-14 Ensemble neurostimulateur électrique Withdrawn EP2382007A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2009900289A AU2009900289A0 (en) 2009-01-27 Electrical neurostimulator package
PCT/AU2010/000029 WO2010085838A1 (fr) 2009-01-27 2010-01-14 Ensemble neurostimulateur électrique

Publications (1)

Publication Number Publication Date
EP2382007A1 true EP2382007A1 (fr) 2011-11-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP10735420A Withdrawn EP2382007A1 (fr) 2009-01-27 2010-01-14 Ensemble neurostimulateur électrique

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EP (1) EP2382007A1 (fr)
CN (1) CN102481449A (fr)
WO (1) WO2010085838A1 (fr)

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US9042991B2 (en) * 2013-08-14 2015-05-26 Syntilla Medical LLC Implantable head mounted neurostimulation system for head pain
US20220257956A1 (en) * 2013-10-23 2022-08-18 Shiratronics, Inc. Implantable head located radiofrequency coupled neurostimulation system for head pain
US10960215B2 (en) 2013-10-23 2021-03-30 Nuxcel, Inc. Low profile head-located neurostimulator and method of fabrication
CN107206244B (zh) * 2015-01-21 2018-07-27 领先仿生公司 耳蜗植入物以及组装耳蜗植入物的方法
DK3111993T3 (da) * 2015-06-30 2020-08-24 Oticon Medical As Gennemføringskonnektor
US20190015662A1 (en) * 2017-07-12 2019-01-17 Milind Chandrakant Raje Monolithic component for an implantable medical device
CN107585735B (zh) * 2017-09-22 2019-10-29 上海交通大学 一种人工耳蜗电极及其制备方法
CN110292708A (zh) * 2019-07-26 2019-10-01 杭州诺为医疗技术有限公司 一种用于神经刺激器线圈组件的封装装置及封装方法
US11147978B2 (en) * 2019-10-30 2021-10-19 Wyss Center For Bio And Neuro Engineering Feedthrough protective cover

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Also Published As

Publication number Publication date
CN102481449A (zh) 2012-05-30
WO2010085838A1 (fr) 2010-08-05

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