EP2370133A1

EP2370133A1 - Single-use injector capable of pumping and having a flexurally elastic housing

Info

Publication number: EP2370133A1
Application number: EP09796618A
Authority: EP
Inventors: Rudolf Matusch
Original assignee: LTS Lohmann Therapie Systeme AG
Current assignee: LTS Lohmann Therapie Systeme AG
Priority date: 2008-12-18
Filing date: 2009-12-03
Publication date: 2011-10-05
Also published as: WO2010069470A1; US20110251551A1; JP5738195B2; JP2012511978A; DE102008063518A1; US8535263B2

Abstract

The invention relates to a single-use injector comprising a housing (200) accommodating a mechanical spring energy reservoir (50), a cylinder/piston unit (100), a piston-actuating ram (60) and a trigger unit (80), the spring-loaded piston-actuating ram (60) being supported on the housing via support rods, draw hooks or elastic flexural beams. The housing of the injector consists of a thin-walled sheet metal part. Said sheet metal part supports the pretensioned spring energy reservoir and the cylinder/piston unit. The piston (111) of the cylinder/piston unit can be manually displaced by means of a pump rod (140). The single-use injector according to the invention is compact and has only few components, it is easy to handle and allows secure storage and functioning. The cylinder/piston unit can be filled when mounted.

Description

Pumpable disposable injector with a flexurally elastic housing

Description :

The invention relates to a disposable injector with a housing in which or on which - at least partially - at least one mechanical spring energy storage, at least one - at least temporarily Wirkstoffbefüllbare - cylinder-piston unit, at least one piston actuation plunger and at least one trip unit are arranged, the Kolbenbetäti - Compression plunger between the spring energy storage and the piston of the cylinder-piston unit is positioned, wherein the spring energy storage at least a biased spring element summarizes, the piston of the cylinder-piston unit - biased spring element - is moved separately via a pump rod, wherein the pump rod on the piston or on a piston rod of the piston is detachably coupled, wherein the spring-loaded piston actuating ram is supported on the housing side support sections, wherein the located between the individual support sections and the piston actuating ram Kontaktzon e is part of an outwardly wedge pair of wedge gears.

From DE 10 2007 031 630 Al, inter alia, such an injector is known. However, the injector does not have a hand-operated movable piston. With the exception of the mechanical spring of the spring energy storage almost all components of the injector are elaborately made of plastic by injection molding. Mechanically highly stressed components are additionally made of glass fiber reinforced. The present invention is therefore based on the problem to develop a modular disposable injector ector, which has only a few components with a small size and ensures safe storage and function with ease of use and cost-effective production. Also, the cylinder-piston unit of the strained disposable injector should be able to be filled in the installed state.

This problem is solved with the features of the main claim. For this purpose, the housing consists of a thin-walled sheet metal part having at least two legs. The two legs have at the free ends - as a receptacle of the cylinder of the cylinder-piston unit - each have an angled holding element or a recess. The at least partially elastic sheet metal part has at least two pressure rods or at least two pull hooks whose free ends are each bent to form a support portion for the piston actuating ram angularly or sheet metal part has as a leg elastic bending beams, which in the central region to form a support portion for the piston actuating ram each Z- or S-shaped bent.

With the invention, for example, a needle-free disposable injector is presented, the piston actuation stamp is released in a triggering operation of the disposable injector. For this purpose, for pretensioning and holding the spring energy store, the piston-actuating ram is attached via at least one housing attached to the housing. arranged or in the housing integrated support rod, hitch or flexible elastic leg held positively. The one or more support rods, towing hooks or legs are held by a housing at least partially surrounding triggering element to the use of disposable ejector in its locked position. To trigger the injector or the support rods, hooks or legs are released transversely to the triggering direction, so that the piston actuating ram - under the action of Federenergiespeichers - at least approximately parallel to the center line of the disposable injector can move to the cylinder in the cylinder piston Unit to eject existing injection solution through at least one nozzle.

The housing is a simple, thin-walled sheet metal part, possibly even only a metal strip, which stores the mechanical or pneumatic spring of the spring energy storage together with a piston actuating punch and a cylinder-piston unit in cooperation with the triggering element. The stamped or cut, multi-curved sheet metal part is extraordinarily cheap to produce from a ferrous material or a non-ferrous metal. Ideal materials are those which have a high elastic limit, a high tensile strength and a high yield ratio. If necessary, these can also be high-quality plastics and / or composite materials. Almost any material, including glass or ceramics, is suitable.

In addition, the needle-free disposable injector has a cylinder-piston unit which can be filled with a tensioned spring accumulator by a manual pumping movement. Among other things, a pumping rod is engaged from the outside into the piston of the cylinder-piston unit arranged in the injector, so that the piston can be moved by means of the pumping rod. After proper filling, the cylinder-piston unit can be replaced with a Ril plugs are sealed germ-free. Possibly. The pump rod is disengaged and pulled out of the housing.

Further details of the invention will become apparent from the dependent claims and the following descriptions schematically illustrated embodiments.

Figure 1 disposable injector with two support rods;

Figure 2 as Figure 1, but pivoted by 90 degrees;

FIG. 3 as in FIG. 1, but after the injection;

FIG. 4 shows a longitudinal section of the metal strip, cf. also FIG. 2;

Figure 5 upper portion of the metal strip;

FIG. 6 is a cross-sectional view of FIG. 2;

Figure 7 upper housing area during assembly;

FIG. 8 is a cross-sectional view of FIG. 7;

FIG. 9 Enlarged detail of FIG. 1;

Figure 10 disposable injector with two draw hooks and cuboid

Plunger, piston in lower position, - Figure 11: as shown in Figure 10, but pivoted by 90 degrees and with a piston moved to the upper position; FIG. 12 as in FIG. 11, but without the pumping rod and after

Injection;

Figure 13 longitudinal section through the sheet metal housing; Figure 14 upper portion of the sheet metal housing; FIG. 15 is a cross-sectional view of FIG. 11;

FIG. 16 disposable injector with two bending petals; Figure 17 as Figure 16, but pivoted by 90 degrees; FIG. 18 as in FIG. 1, but after the injection; FIG. 19 is a cross-sectional view of FIG. 17; FIG. 20: Dimetric view of the rear injector end with pump rod.

1 shows a disposable or disposable injector with a permanently charged spring energy storage. The disposable injector consists of a housing (200) surrounded by a trigger element (82) and a protective cap (120), e.g. with a solution for injection pre-filled cylinder-piston unit (100), a piston actuation plunger (60) and a helical compression spring (50) as a spring energy storage. The cylinder-piston unit (100), the piston (111) by means of a releasable pump rod (140) can be moved with tensioned helical compression spring (50), sits largely in the protective cap (120).

The housing (200) is a bent to a "U" sheet metal strip (201), see Figure 4. The unwound, eg 18 mm wide, sheet metal strip (201) is about 240 millimeters long. 201) has a wall thickness of, for example, 0.5 millimeters, The bent sheet metal strip (201) consists of a central end plate (210) and two legs (220) protruding at least approximately perpendicularly from the legs (220) Angled at each of their free ends, they are angled inward by 90 degrees in order to form in each case a holding element (221) .The holding elements (221), which are for example 1.5 to 3 millimeters long, project towards one another. which is aligned parallel to the end plate (210).

Instead of the hook-shaped holding element (221) may be provided in each leg (220) has a recess into which the cylinder of the cylinder-piston unit (100) can be hooked by means of a respective pin. At the transition points between the end plate (210) and the legs (220), according to FIG. 5, two stiffening cords (211) are pressed in each case. The stiffening beads (211) protrude into the front plate (210) so far that they also center the last turn of the helical compression spring (50) on the front plate (210). The end plate (210) has a bore (292) in the middle, through which the pump rod (140) is inserted.

In the lower half of each leg (220) is an e.g. 9 mm wide support rod (240) arranged, cf. Figure 4. The support rod (240) is created by working out a U-shaped, e.g. 0.2 to 0.5 millimeters wide gap (228). The gap (228) ends in the respective lower region of the legs (220), ie in the vicinity of the holding elements (221) in bores (229) to minimize the notch stresses occurring there. In contrast to the substantially planar legs (220) of the support rod (240) is bent several times, cf. also FIG. 9. The support rod (240) consists of a bending beam (248), a support section (241) and a contact section (242). The bending beam (248) introduces the clamping force of the spring energy store (50) into the leg (220) carrying it. On the support section (241), the piston actuating ram (60) rests on a non-triggered disposable injector. About the contact portion (242), the support rod (240) based on the trigger element (82) over a large area.

The support section (241), it measures in the longitudinal direction about 1.5 to 3 millimeters, see. FIG. 9, includes, for example, an angle of 110 to 115 degrees with the bending beam (248). Compared to the vertical, it is tilted by 60 degrees. The contact section (242), which is 1 to 2 millimeters wide in the longitudinal direction, encloses a 140 ° angle with the support section (241). He lies according to Figures 1 and 4 over a large area on the trigger element (82). For example, the trigger element (82) has a ceramic armor in the contact area.

Possibly. have the elastic support rods (240) in the lower region a - to the center line (5) at least approximately parallel - longitudinal bead to increase its buckling stiffness. The support rods (240) always spring outward as elastic bending beams (248) in order not to brake when the helical compression springs (50) are extended.

The support rods (240) can also be replaced by draw hooks. The latter are also delimited via a U-shaped slot opposite the respective leg (220). However, here are the holes (229) in the vicinity of the face plate (210). The respective support portion of the tow hooks is e.g. designed as the support sections (251) of the tow hook (250) of Figure 12.

According to Figures 1 and 9 is located on the support portions (241) of the support rods (240) of the piston actuating ram (60). The latter is here a U-shaped bent metal strip, which consists of a central part, the stamp plate (73) and two Führungsschenkein (78). The stamping plate (73) is oriented parallel to the end plate (210). The Leadership Tavern! (78) are at right angles to the top. Between the guide legs (78) sits the helical compression spring (50). Possibly. are the FührungsSchenkel (78) opposite the punch plate (73) provided with stiffening beads, see. For this purpose, the stiffening beads (211) of the sheet metal part (201) from FIG. 5.

According to FIG. 9, the stamping plate (73) has in the region in which it bears against the respective support section (241) of the support rod (240). is present, for example, a 20 ° chamfer (75) to ensure a large-scale system.

According to FIG. 1, the piston-actuating ram (60) has a width that is slightly smaller, that is to say approximately 0.1 to 0.3 millimeters, than the regular distance of the two limbs (220). Accordingly, the piston-actuating ram (60) is guided laterally on the legs (220). The FührungsSchenkel (78) of the piston actuating punch (60) are guided on the inner wall (89) of the trigger element (82) with clearance, see. FIG. 2.

The stamping plate (73) has u.a. according to Figures 1 to 3 and 9, a central bore (76) to u.a. the piston (111) of the cylinder-piston unit (100) in addition to back lead.

The two pressure-loaded support rods (240) hold the piston-actuating ram (60) against its stamping plate (73) in its pretensioned position, cf. Figures 1 and 9. For this purpose, the support rods (240) are based with their Abstutzabschnitten (241) on the lower 20 ° bevel (75) of the punch plate (73). The size of the respective contact surface between the individual support portion (241) and the corresponding 20 ° bevel (75) is in the range of 5 to 20 mm ² .

The made of sheet metal housing (200) is largely surrounded by a trigger element (82) in which it sits slidably. The triggering element (82) is here a square tube closed at the rear with a cover (285), which is part of a triggering unit (80). The made of plastic, such as a polyamide tube (82), for example, has a wall thickness of 1.5 to 2.5 millimeters, has in its central region two opposing, eg rectangular window (83) or openings. The windows (83) are for example 10.5 millimeters wide and longitudinal, ie parallel to the center line (5), 3.75 millimeters high. In the case of a triggered injector, for example, they respectively completely take up the abutment section (242) and the support section (241) of the individual support bar (240), cf. Figure 3.

In the rear region of the square tube (82), three elastic locking straps (181-183) projecting inwards are arranged a few tenths of a millimeter, cf. FIGS. 7 and 8. The latching sheets (181-183) have e.g. each a rectangular shape. Its wall thickness corresponds to approx. 50% of the wall thickness of the square tube (82). They delimit on three sides opposite the wall of the square tube (82) or opposite the nearest locking tab on column (185). The gaps (185) have a width of e.g. 0.5 millimeters. The width corresponds to the wall thickness of the front plate (210). At the places where two columns (185) abut each other at right angles, the locking tabs (181-183) are rounded.

The eccentrically arranged, formed on the square tube locking tabs (181-183) secure the position of the metal strip (201) at three points (186-188). They protrude several tenths of a millimeter into the interior of the trigger element (82). The first location (186) is the gap between the front (181) and middle latch tabs (182). In the horizontal gap there, the front plate (210) engages when the metal strip (201) with the between the piston actuating punch (60) and the end plate (210) clamped helical compression spring (50) is mounted for further intermediate storage.

The second location (187) is the gap between the middle (182) and rear latch tabs (183). According to FIGS. 1 and 2, the end plate (210) is seated here in the case of a fully assembled, untriggered disposable injector. By the engagement of the Face plate (210) in this gap, a withdrawal of the housing (200) from the square tube (82) - after removal of the protective cap (120) - prevented.

The third digit (188) is the gap above the rear locking tab (183). In this position, the metal strip (201) remains after the triggering of the injector, see. Figure 3. There he is secured against unwanted disassembly of the then used injector.

Possibly. are the respective upper corners of the locking tabs (181-183) - so those that are the lid (285) facing - sharp-edged, so that the metal strip (201) can be pushed only in the square tube (82). A movement in the opposite direction is then, even with great effort, impossible.

The windows (83) and the gaps (185) are in the ready mounted disposable injector e.g. by a permanently glued or shrunk, e.g. Labeled possibly elastic film covered dust-tight.

In the variants shown here, all locking elements (181- 183) on the trigger element (82) are arranged. They fix partly temporarily, partially permanently the position of the end plate (210) relative to the trigger element (82). It is also conceivable that the latching elements (181-183) are arranged by a housing (200), e.g. cam-like locking element to replace. The latter would then intervene in corresponding recesses of the trigger element (82) in order to realize comparable latching positions.

The lid (285) seated on the rear end of the square tube (82) is adhesively bonded, welded, latched or sprained, for example, with the triggering element (82). Possibly. is the disgusting on the trigger element (82) also formed. The lid (285) has a central bore (292) for the pump rod (140). According to Figure 10, the lid (285) on its outer side also have a tubular cap adapter (289). On the latter, a pump rod cap (130) is releasably attached. The pump rod cap (130) tightly surrounds the pump rod (140) located in its rearward position as shown in FIG.

The cylinder-piston unit (100) consists in the embodiment of a, with an injection solution (1) or a solvent, e.g. Water for injections, filled, transparent cylinder (101), in which, according to Figure 1, a piston (111) sits in its rear position.

The cylinder (101) is e.g. a clear, thick-walled pot made, for example, from the amorphous thermoplastic cycloolefin copolymer (COC). The cylinder bore is, for example, cylindrical or truncated cone-shaped. In the center of the bore, the cylinder bottom of which is at least approximately adapted to the contour of the front end face of the piston (111), there is e.g. a short cylindrical nozzle-like bore (106). Its diameter is about 0.1 to 0.5 millimeters. This bore (106) is one to five times as long as its diameter. It ends in a cylindrical recess (107) of the bottom-side, outer end face (103) of the cylinder (101), cf. FIG. can in the bottom of the cylinder (101) and two or more nozzle-like bores (106) may be arranged.

An adhesive ring (108) adheres firmly to the end face (103) around the recess (107). The latter covers almost the entire end face (103) of the cylinder (101). The spatial outer contour of the cylinder (101) is designed in the embodiment example cuboid. However, it can also be cylindrical. The cross-section of the outer contour - it is oriented transversely to the center line (5) - has a square area in the center cylinder area with a central bore. The cross section is dimensioned so that the cylinder (101) slides with a small clearance in the interior of the square tube (82).

The cylinder (101) has in its outer contour in the upper, the square tube (82) facing quarter a e.g. circumferential retaining notch (104) with a e.g. rectangular notch cross section. Above the retaining notch (104), the cylinder (101) tapers in the shape of a truncated pyramid. The angle enclosed by opposing pyramidal surfaces is e.g. 20 to 30 degrees. If necessary, the retaining notch (104) can also only consist of two mutually opposing individual notches.

The e.g. Clear-faced cylinder (101) has a cylinder inner wall (109), which ends in the region of the rear cylinder end face in an annular groove (105) for receiving a sealing element (116). The piston (111) and the sealing element (116) close the filled cylinder interior (110) sterile.

In the cylindrical or conical bore of the cylinder (101), for example, the rodless piston (111) is seated here. For example, of Teflon ^® derivative tetrafluoroethylene / hexafluoroethylene copoly mer (FEP) piston produced (111) has on its front, at least approximately conical configuration end face an axial annular groove (112) for receiving a sealing ring (114) or a permanently elastic sealing compound , The length of the piston (111) is chosen so that the retracted piston (111), see. Figure 3, at least one millimeter beyond the rear upper edge of the cylinder (101) protrudes. The central region of the piston (111) is designed waisted. The circumferentially waisted area has one Length corresponding to approx. 30% of total piston length. The waisted region has a diameter that is 16 to 20% smaller than the maximum inner diameter of the cylinder in the area of the solution-receiving cylinder interior (110).

The piston (111) has at its rear side e.g. a central, frusto-conical pin (118) which projects into the bore (76) of the stamping plate (73) with play. In the pin (118) is a centric, conical piston recess (115) with the bottom (117), see. FIG. 9, for coupling the pump rod (140). Possibly. the pump rod (140) is also formed on the piston (111). The cone angle of the piston recess (115) is e.g. an angular degree. The pump rod (140) has for coupling to the piston (111) at its lower end - u.a. according to Figure 9 - a conical pointed thread (141). The cone angle of the pointed thread (141) is e.g. six degrees of angle. The thread of the pointed thread (141) presses when screwing the pump rod (140) into the piston recess (115), the required mating thread. The screwing process is completed when the front end of the pump rod (140) with the narrow tip of the frusto-conical end face (145) contacts the base (117).

The special thread (141) used for coupling purposes only needs low tightening and unscrewing forces. Of course, other releasable couplings may be used, such as e.g. a key / keyhole system or a simple latching system.

The pump rod (140), cf. Figures 1 to 3, over most of their length, for example, a constant cross-section. Their largest diameter is about two millimeters in the embodiment. It is made of a glass fiber reinforced polyamide, for example. At its rear end, which protrudes from the bore (292) of the lid (285), it has two differently divided scales (148) and (149), cf. Figure 20. The scale (148) fits to a cylinder-piston unit (100), whose cylinder (101) has a mean inner diameter of seven millimeters, while the other scale (149) belongs to a cylinder (101) with six millimeters inner diameter. The different sized cylinders (101) can optionally be adapted to the injector.

Both scales (148, 149) each have horizontal graduations. These graduations lie in planes which are oriented normal to the center line (5). For example, each graduation has the length of half the circumference of the pump rod. The divisions of a

Scale (148, 149) are all on top of each other. You can e.g. be colored, black or white lines or stamped as notches in the pump rod. Instead of dashes, you can also use points or numbers.

Possibly. For example, the rear end of the pumping rod (140) may be provided with a structure, e.g. a transverse or Längsrillung, a Riffeiung or the like. Also, the cross-section may be partially flattened or have a larger diameter than the region extending through the piston-actuating ram (60).

According to FIG. 20, the front scale (148) assigned to the larger cylinder is extended by a half-cylinder (146) in order to identify the assignment. The two lower graduations located directly at the level of the bottom (86) mark the nominal volume of the respective cylinders (101). The respective upper scale indicates that the piston (111) is fully inserted into the cylinder (101). Each other graduation of the scales (148, 149) is e.g. for 0.1 milliliters.

According to FIGS. 1 and 2, a pot-shaped protective cap (120) is pushed onto the cylinder (101) from below. The The protective cap (120), which in principle consists geometrically of five flat walls, encloses the cylinder (101) laterally with little play. Its upper, for example, planar end face contacts the front end face of the square-shaped triggering element (82). The outer wall of the protective cap (120) has a profiling or structure to facilitate removal from the cylinder (101). In the exemplary embodiment, a groove profile (122) is used as profiling.

The bottom of the protective cap (120) has a central adapter opening (123), which ends in front of the Stirnflächenausnehmung (107) of the cylinder (101). The adapter opening (123) together with the recess (107) at least approximately forms a Luer inner cone. A plastic or rubber stopper (125), which also projects sealingly into the recess (107) of the cylinder (101), is inserted in the adapter recess (123). The protective cap (120) adheres to the cylinder (101) via the adhesive ring (108). The latter has a considerably higher adhesive force relative to the cylinder (101) than relative to the bottom of the protective cap (120). In order to additionally ensure the adhesive force difference, the bottom with a profile, e.g. of concentric rings, or provided paragraph, so that the contact surface with respect to the adhesive ring (108) is smaller than the contact surface between the adhesive ring (108) and the cylinder-side end face (103).

Between the stamp plate (73) and the end plate (210) of the sheet metal strip (201) is biased sitting the helical compression spring (50). The spring force is transmitted to the support rods (240) via the stamp plate (73). Due to the inclination of the

Bevel (75) of the stamping plate (73), the support rods (240) are urged radially outward in the manner of a wedge gear, cf. Figure 9. The chamfers (75) contact the inclined support portions (241) of the support rods (240). The plant sections (242) are located 1

at least almost flat on the inner wall of the square tube (82). The square tube (82) thus supports the wedge gear-related radial force permanently.

According to Figures 1 and 2, the square-shaped release element (82) and the protective cap (120) touch at their end faces. As a tamper-evident closure, this area is additionally surrounded by a banderole (90) as a security element. The tear-off or separable band (90) is e.g. a paper or film strip coated on one side with an adhesive. The foil strip surrounds e.g. single layer once the composite of trigger element (82) and protective cap (120). He glued the parts (82) and (120) temporarily. To unlock the injector or to remove the protective cap (120) - in preparation for the use of the injector - the band (90) is removed or separated so that the adhesive bond between the trigger element (82) and the protective cap (120) is released , In the exemplary embodiment, the tear-off lug (96) lying in the region of the triggering element (82) is gripped and thus the

Banderole (90) e.g. partially settled. In doing so, the band (90) tears at a defined, e.g. rectilinear predetermined breaking point (93), which lies exactly in the region of the end faces. Consequently, only the part (91) of the band (90) resting on the release element (82) is removed during the release procedure.

For the assembly of the injector, first the helical compression spring (50) is plugged together with the piston actuating punch (60) and the sheet metal strip (201). For this purpose, the helical compression spring (50) in the finished formed sheet metal strip (201) is inserted so that a spring end on the end plate (210) comes to rest. On the other spring end of the bow-shaped piston actuating punch (60) is pushed. Now with the help of a mounting device of the sheet-metal strips (201) leading outside or inside the helical compression spring (50) between the end plate (210) and the piston-actuating ram (60) so far - against the spring action - that the legs (75) of the end face (74) come to rest behind the support sections (241). In this case, the abutment sections (242) lying laterally against the piston-actuating ram (60) facilitate the assembly process.

Now the combination of the tensioned spring (50), the

Sheet metal strip (201) and the piston actuating punch (60) - still clamped in the mounting device - inserted from below into the square tube (82). The insertion process is completed when the face plate (210) in the between the Rastla- see (181) and (182) located gap (186) engages. In this position (186), the free ends of the legs (220) project down out of the square tube (82).

In a further assembly step, the filled cylinder-piston unit (100), with the mounted pump rod (140) and the guide pin (118) of the piston (111) ahead, into the lid (285) and possibly with pump rod cap (130) plugged square tube (82) inserted so that on the one hand the guide pin (118) protrudes into the bore (76) of the Kolbenbetätigungsstem- pels (60) and on the other hand, the holding elements (221) of the legs (220) in the retaining notch ( 104) of the cylinder (101). In this case, the pump rod (140) is inserted through the bores (219) and (292). Starting from this position, the square tube (82) is pushed further over the sheet metal strip (201) until the end plate (210) engages in the gap (187) located between the latching tabs (182) and (183). Here, the holding elements (221) firmly engage in the retaining notch (104) and thus fix the cylinder-piston unit (100) in the square tube (82) inseparably. In an attempt, the To pull the cylinder-piston unit (100) out of the release tube (82), the retaining elements (221) engaging in the retaining notches (104) are pressed against the inner wall (89) in a braking and stabilizing manner.

Compared to the assembly step shown in Figure 1 only the attachment of the tamper-evident closure (90) and the gluing or covering the window (83) and the column (185) by means of a labeled film is missing.

A second variant of a disposable injector is shown in FIGS. 10 to 15. This injector has no metal strip (201) as a housing, but a sheet metal cross (202), see. Figures 13 and 14. In Figure 14, the upper portion of the already formed sheet metal cross (202) is shown. Here, the sheet metal cross (202) has the already known end plate (210), at the two wide, long legs (220) and offset by 90 degrees - pivoted about the center line (5) - two narrow short leg (250) are arranged , The mentioned proportions are only to be understood as examples.

The long, broad legs (220) have the task of holding the cylinder (101) over the retaining elements (221), cf. Figure 10. However, here have these legs (220) no support rods.

The short, narrow legs (250), cf. FIG. 13, replace the support rods as pull hooks. For this purpose, the draw hooks (250) shown here each have a support section (251) at their free, lower ends, which is formed by a simple inward bending of the pull hook end - for example by 60 degrees of angle. On the support sections (251), the plate-shaped piston actuating ram (60) with its chamfers (75) is located in the tensioned spring energy store (50). According to FIGS. 10 to 12, the piston-actuating punch (60) is a flat plate with, for example, a square or rectangular end face.

The towing hooks (250) are supported on the inner wall of the triggering element (82) below the edges (85) belonging to the longitudinal grooves (81) when the spring energy store (50) is tensioned. Again, the support sections (251) and the chamfers (75) form a wedge gear that urges the tow hooks (250) outward. When removed, the spring-elastic towing hooks (250) are exposed to the outside. As a result, after the triggering of the injector - even independently of the effect of the wedge gear mechanism - they deviate outwards so as not to obstruct the helical compression spring (50) as it changes its length.

In order to allow for outward urging of the towing hooks (250) upon release of the injector, e.g. Square-shaped release element (82) on the inner wall (89), the two previously mentioned, opposite longitudinal grooves (81), see. Figures 11 and 12. Each longitudinal groove (81) terminates in the central region of the trigger element (82) in a return edge (84). When triggered, the edges (85) - by moving the trigger element (82) - under the support sections (251) of the Zugha- ken (250), whereby these and the longitudinal grooves (81) recede.

Because of the arrangement of the longitudinal grooves (81) in the square tube (82), the locking tabs (181-183) over which the sheet metal cross (202) is locked in different positions, moved in the direction of the nearest corner inner edge.

Instead of the described box-like sheet metal cross (202) can also be a sheet metal star with six, eight or more legs be used. For example, a sheet metal star has an octagonal face plate (210), of which at least approximately vertically four legs with holding elements (221) and four further legs with support portions (251) are arranged. In this case, the holding elements (221) and the support sections (251) alternate. The piston-cylinder unit (100) and the trigger element (82) have then also here, for example, octagonal cross-sections. The sheet metal cross or the sheet metal star can also be built from individual metal strips in which the metal strips in the region of the end plate (210), for example, welded or riveted together.

Figures 16 to 18 show a pumpable disposable injector with a housing (200) without draw hooks or pressure supports. The housing (200) is here a possibly made of spring steel, bent sheet metal strip (201), which consists of a central end plate (210) and two of which at least approximately vertically projecting flexurally elastic legs (220). The at least partially aligned approximately parallel to each other

Legs (220) are angled at their free ends by 90 degrees in each case in order to form there in each case a holding element (221).

In the middle region, each limb (220) is bent in a Z-shaped or S-shaped manner, whereby the double-angle bend is mirror-symmetrical to the center line (5), cf. Figures 16 and 18. In Figure 18, the sheet metal strip (201) is shown in the relaxed state. The central area is here a zone that extends above and below the center of the housing (200) by approximately one quarter of the entire housing length.

Each leg (220) consists of a front holding portion (233), a middle support portion (231) and a Rear abutment section (232). The holding section (233) is predominantly straight and, according to FIG. 16, runs parallel to the center line (5). It is followed by the relatively short support section (231). The support section (231), it measures in sheet metal strip longitudinal direction about 1.5 to 3 millimeters, closes with the holding portion (233), for example, an angle of 112 to 118 degrees. Compared to the vertical, it is tilted by 65 degrees.

On the support section (231), the piston actuating ram (60) rests on a non-triggered disposable injector, cf. Figure 16. He is thus charged to train.

The contact section (232) adjoins the support section (231). It extends to the face plate (210). The contact section (232) encloses the support section (231) - according to FIG. 18 - at an angle of 113 ± 3 angular degrees. He lies on a large area on the trigger element (82).

The two loaded on train legs (220) hold the piston actuating ram (60) on the stamp plate (73) in its biased position, see. FIG. 16.

The triggering element (82) surrounding the housing (200) is here a plastic closed with a lid (285), e.g. a polyamide-fabricated tube (82) having a front (21) and a rear portion (22).

The front portion (21), which relates approximately to the front third of the trigger element (82), has the shape of a square tube with a square ring cross-section. The four side walls (87, 88) each have the same wall thickness of 1.5 to 2.5 millimeters in this area (21). The rear region (22) has a rectangular ring cross section, cf. Figure 16, wherein the side wall (88) is about 5 percent wider than the side wall (87). In the side wall (87), a longitudinal groove (83) is partially arranged, which extends to the rear end of the trigger tube (82). In the region of the longitudinal groove (83), the wall thickness of the side wall (87) is reduced to eg 0.5 millimeters. The longitudinal groove (83) terminates at the front in, for example, a recessed ramp (84), which is inclined by approximately 75 degrees with respect to the inner wall (89). The inclination has the same orientation as the inclination of the support portions (231) of the legs (220) of the sheet metal strip (201).

The longitudinal grooves (83) take in the case of a triggered injector in each case the contact portion (232) and the support portion (231) of the single leg (220) largely on, see. FIG. 18.

In the rear area of the release tube (82), according to FIG. 17, in the right side wall (88), the locking lugs (181-183) known from the previous variants are arranged, cf. also FIGS. 16, 18 and 19.

In the variant shown so far, all locking elements (181-183) are arranged on Ausiöseeiement (82). They fix partly temporarily, partially permanently the position of the end plate (210) relative to the trigger element (82). It is also conceivable to replace the latching elements (181-183) by at least one latching element arranged on the housing (200). The latter then accesses e.g. in corresponding recesses of the trigger element (82) to realize comparable locking positions.

At the rear end, the trigger tube (82) is closed by a cover (285), which has two cover lids lying opposite one another. has tongues (286). They respectively fill the cross section of the longitudinal grooves (83) of the side walls (87) in the rear trigger tube area. The cover tongues (286), which are chamfered at their free ends to the interior (29), protrude so far into the release tube (82) that, according to FIG. 17, they laterally engage the metal strip (201) in the region of the end plate (210) can support little game, provided that the injector is in the commercial state.

Possibly. the lid is formed on the trigger element (82).

To prepare for the use of the described, loadable injectors, the empty cylinder-piston unit (100), cf. Figure 10, are filled with tensioned spring energy storage (50). For this purpose, the pump rod cap (130) is pulled off the trigger element (82) at the rear and the rubber plug (125) is removed from the adapter opening (123) of the protective cap (120) at the front. Subsequently, for example, an injection needle (137) is connected to the adapter opening (123) via a double cone adapter (135). To fill the cylinder (101), the piston (111) is sucked back by means of the pump rod (140). The rear sealing element (116) remains stationary on the collar (105), even if the waisted region of the piston (111) passes through the sealing element (116). Has the piston (111) reached its rear position, cf. 11, the sealing element (116) rests again sterile and radially sealing on the piston (111).

After filling and, if appropriate, venting of the cylinder (101), the adapter opening (127) together with the recess (107) can be sterile-closed at the front to temporarily store the filled injector (127). the. Also, the pump rod cap (130) can be re-attached to the cap adapter (289).

The disposable injector variants with manually operated piston (111) described here can also be combined with a so-called two-chamber system, as described, inter alia. in DE 10 2008 003 105 are published.

To use the single disposable injector this is first released by the detachment of the tear-off tab (96) and the rear banding portion (91), see. Figure 1. Subsequently, the protective cap (120) is withdrawn from the cylinder-piston unit (100). Now, the injector, with the adhesive ring (108) ahead, is positioned on the injection site. The disposable injector is held in the fist on the square tube (82). For example, the thumb of the holding hand rests on the lid (285), e.g. like when you press a ballpoint pen.

Now the square tube (82) is moved in the direction of the cylinder-piston unit (100). In this process, the trigger element (82) slides on the metal strip (201) linearly downwards, ie in the direction of the injection site. The abutment portions (242) of the support rods (240) slip over the edge (85) and jump under the force of the Federeiements (50) unlocking outward into the window (83), see. FIGS. 1, 3 and 9. In the variant according to FIGS. 10 to 15, the draw hooks (250) slide over the edges (85) so that the support sections (251) dip outwardly into the longitudinal grooves (81). The metal strip (201) of the variant shown in FIGS. 16 to 19 slips with its abutment sections (232) over the edges (85) so far into the wide longitudinal grooves (83) that the holding sections (233) engage, for example the inner wall (89) of the trigger tube (82) create, see. FIG. 18. In all three variants, the support sections (231, 241, 251) release the piston-actuating ram (60). This rockets unhindered down. In this case, the end face (74) of the stamping plate (73) strikes the end face of the piston (111), which was previously located a few tenths of a millimeter or a few millimeters away. The piston (111) pushes the injection solution or the medicament (1), for example initially with 300 x 10 ⁵ Pa through the nozzle (106) until the cylinder (101) is emptied, see. Figures 3, 12 and 18. With the delivery of the injection solution (1), the injection process is completed.

The exemplary embodiments show injectors whose housing-side limbs (220, 250) are each aligned in pairs at least approximately parallel to one another - an angular deviation of ± 2 angular degrees is permissible. The legs (220, 250) are in this case in parallel planes, wherein the planes - seen in injector cross section - form the opposite sides of a rectangle. The plane of the injector cross section is normal - that is perpendicular - to the center line (5). These sides may also belong to a rhombus, a parallelogram, a trapezoid or an oblique square.

In addition, the legs (220, 250) and the pressure rods (240) each have the same length in pairs. That is not necessary. Thus, for example, the pressure rods (240) may be of different lengths if, correspondingly, the contact surfaces of the piston-actuating punch (60) and the windows or longitudinal grooves (83, 81) are positioned offset. List of reference numbers:

1 solution for injection; drug

5 Center line of the injector, longitudinal direction

21 front area of (82)

22 rear area of (82) 29 interior

50 spring element, helical compression spring, spring energy storage

60 piston actuating punch

76 bore

73 stamp plates

74 front side, bottom

75 chamfer, 20 ° chamfer

76 bore 78 guide leg

80 trip unit

81 longitudinal grooves

82 Tripping element, square tube 83 Windows, openings, longitudinal grooves

84 return edge

85 edge, sharp-edged

86 contact zone

87 side wall with longitudinal groove (83) 88 side wall without longitudinal groove (83)

89 inner wall

90 tamper-evident closure, band, security element

91, rear banderole section, at (82); part 92 front band section, on

93 predetermined breaking point, perforation

96 tear-off flag

100 cylinder-piston unit

101 cylinders

103 face

104 retaining notch

105 fret, ring groove

106 bore, nozzle

107 recess in the end face

108 adhesive ring

109 inner wall of the cylinder

110 indoor environment

111 pistons

112 ring groove

113 front side, rear; cone

114 sealing ring, seal

115 piston recess, bore

116 sealing element in (105)

117 recess base, bottom of (115)

118 guide pins

120 protective cap

122 groove profile

123 adapter opening

125 plugs

130 pump bar cap

135 double cone adapter

137 injection needle

140 pump rod 141 tapered thread, pointed thread

145 front side, frustoconical

146 half cylinder

147 paragraph (for small cylinders) 148 markings, half notches for large cylinders

149 marks, half notches for small cylinders

181 latching tab, front; locking element

182 latching tab, center, - latching element 183 latching tab, rear; locking element

185 column

186 1st position

187 2nd position 188 3rd position

200 housings; Sheet metal part, thin-walled

201 sheet metal strip; Sheet metal part 202 Sheet metal cross; sheet metal part

210 face plate

211 beads, stiffening beads 219 face plate bore

220 thighs, long and wide

221 holding elements

228 slit, U-shaped

229 holes

231 support section

232 plant section

233 holding section 240 support rods, pressure rods

241 support section

242 Installation section 248 Bending beam

250 tow hooks; Thighs, short and narrow

251 support section

285 lids

286 lid tongues

289 cap adapter

291 top of lid (cap bottom)

292 bore

Claims

Claims:

1. disposable injector with a housing (200) in which or on which - at least in certain areas - at least one mechanical spring energy store (50), at least one - at least temporarily active ingredient - cylinder-piston unit (100), at least one piston actuation plunger (60 ) and at least one triggering unit (80) are arranged,

- wherein the piston-actuating ram (60) between the spring energy storage (50) and the piston (111) of the cylinder-piston unit (100) is positioned,

- wherein the spring energy storage comprises at least one biased spring element (50),

- wherein the piston (111) of the cylinder-piston unit (100) - with biased spring element (50) - via a pump rod (140) is movable separately,

wherein the pump rod (140) can be detachably coupled to the piston (111) or to a piston rod of the piston (111),

- Wherein the spring-loaded piston-actuating ram (60) is supported by housing-side support sections (231, 241, 251),

- wherein the contact zone between the individual support sections (231, 241, 251) and the piston-actuating ram (60) is part of an outwardly-urging wedge-gear pair, characterized - That the housing (200) consists of a thin-walled sheet metal part (201, 202),

- That the sheet metal part (201, 202) at least two legs (220, 250), - that two legs (220) at the free ends - as a receptacle of the cylinder (101) of the cylinder-piston unit (100) - each one angled holding element (221) or a recess and have

- That the at least partially elastic sheet metal part (201, 202) at least two pressure rods (240) or at least two

Has draw hooks (250) whose free ends for forming a support portion (241, 251) for the piston actuating ram (60) are each bent angularly or

- That the sheet metal part (201) as a leg (220) has elastic bending beams, which in the central region to form a

Abstützabschnitts (231) for the piston actuating punch (60) each z- or s-shaped bent.

2. disposable injector according to claim 1, characterized

- That the housing (200) consists of a metal strip (201),

that the sheet-metal strip (201) is bent in a U-shape to form two legs (220),

- that the metal strip (201) at the two free ends - as a support for the Kolbenbetätigungsstempei (60) - inwardly angled holding elements (221),

- That in at least one leg (220), a support rod (240) or a draw hook (250) is incorporated, which is bent at its free end, for forming a support portion (241, 251) for the piston-actuating ram (60), angularly.

3. disposable injector according to claim 1, characterized in that the legs (220) of the sheet metal parts (201, 202) are at least five times longer than the leg width.

4. disposable injector according to claim 1, characterized in that the sheet metal part (201, 202) is made of a spring steel.

5. disposable injector according to claim 1, characterized in that the triggering element (82) is a sheet metal part (201, 202) surrounding the trigger tube.

6. disposable injector according to claim 5, characterized in that the triggering element (82) at at least two points (186, 187) notches for temporarily securing the position of the sheet metal part (201, 202).

7. disposable injector according to claim 1, characterized in that the piston actuating punch (60) is a flat plate (73) with a rectangular base or from a U-shaped bent sheet metal strip (73, 78).

8. A disposable injector according to claim 1, characterized in that the piston-actuating ram (60) together with each support rod (240), pull hook (250) or support portion (231) of a leg (220) forms a splined transmission, in which an axial spring force direction is deflected in a radial Abstützkraftrichtung.

9. disposable injector according to claim 1, characterized in that the individual support rod (240), pull hook (250) or leg (220) in each case on the housing (200) is formed and an elastic bending beam (248).

10. disposable injector according to claim 1, characterized in that the pump rod (140) in certain areas a bore (76) of the piston actuating punch (60) traverses.

11. A disposable injector according to claim 1, characterized in that the pump rod (140) protrudes from the rear of the trigger tube (82) or its lid (285) and there len one or more scales (148, 149).