EP2327638B1 - Vorrichtung zum Verpacken von zwei Produkten zum Vermischen und Verteilung des Gemischs aus diesen Produkten - Google Patents

Vorrichtung zum Verpacken von zwei Produkten zum Vermischen und Verteilung des Gemischs aus diesen Produkten Download PDF

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Publication number
EP2327638B1
EP2327638B1 EP20090306161 EP09306161A EP2327638B1 EP 2327638 B1 EP2327638 B1 EP 2327638B1 EP 20090306161 EP20090306161 EP 20090306161 EP 09306161 A EP09306161 A EP 09306161A EP 2327638 B1 EP2327638 B1 EP 2327638B1
Authority
EP
European Patent Office
Prior art keywords
product
bottle
products
liquid
cavity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Not-in-force
Application number
EP20090306161
Other languages
English (en)
French (fr)
Other versions
EP2327638A1 (de
Inventor
Vincent Grek
Julien Leva
Estelle Habert-Ortoli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ONLY FOR CHILDREN PHARMACEUTICALS
Original Assignee
ONLY FOR CHILDREN PHARMACEUTICALS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK09306161T priority Critical patent/DK2327638T3/da
Application filed by ONLY FOR CHILDREN PHARMACEUTICALS filed Critical ONLY FOR CHILDREN PHARMACEUTICALS
Priority to PT93061612T priority patent/PT2327638E/pt
Priority to EP20090306161 priority patent/EP2327638B1/de
Priority to ES09306161T priority patent/ES2394408T3/es
Priority to PL09306161T priority patent/PL2327638T3/pl
Priority to US12/952,384 priority patent/US20110147333A1/en
Priority to CA 2722979 priority patent/CA2722979A1/fr
Publication of EP2327638A1 publication Critical patent/EP2327638A1/de
Application granted granted Critical
Publication of EP2327638B1 publication Critical patent/EP2327638B1/de
Priority to US15/840,821 priority patent/US20190380910A1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0053—Syringes, pipettes or oral dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces
    • B65D81/3211—Separate rigid or semi-rigid containers joined to each other at their external surfaces coaxially and provided with means facilitating admixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means

Definitions

  • the present invention relates, in general, a device for packaging two products to be mixed, including at least one liquid product, and for dispensing the mixture of these products.
  • this invention relates to a combined device for the extemporaneous preparation of drugs in the liquid state, and the secure collection of liquid preparations thus produced.
  • the problem underlying the invention is set out below with reference to this particular application.
  • Oral medication in the form of tablets in the solid state is often difficult for children and for the elderly, this for reasons of palatability in particular, the tablets are often too big.
  • the doses to be prescribed are not uniform, and the current tablets do not allow a custom dose adjustment.
  • the liquid forms of the drugs make it possible to improve the palatability and to personalize the doses, according to the age and the weight of the patients in particular.
  • the liquid forms are quite complicated to implement, this mainly for reasons of stability of the active ingredient in the liquid.
  • extemporaneous liquid preparations consist of a mixture of two components, such as mixing a powder with a liquid or mixing a liquid with another liquid, in order to prepare a reconstituted liquid medicine which may be a suspension or a solution, said drug can be taken in a more or less long time after its reconstitution.
  • the present invention is in the field of the extemporaneous preparation of such liquid medicaments.
  • the mixture is produced thanks to a voluntary action of the user, and it is not possible to eliminate the disadvantages of traditional extemporaneous preparations: risk of contamination for sterile products, risk of loss of part of the components, risk of using only one component and, in general, difficulties in implementing implementation or exploitation of the method to be followed to achieve the correct mixture.
  • Packaging and dispensing assemblies have also been proposed, which make it possible to carry out the extemporaneous mixing of the components by a screwing or unscrewing movement.
  • the principle of these devices is based on the presence of a lid closing a first bottle, which is opaque that is pushed back by screwing this bottle on the opening of another bottle, which then establishes a communication between the two bottles and allows the mixing of their respective contents.
  • the lid is free or secured to the first bottle by means of a hinge.
  • here can be cited the French patents N os 2478607 and 2506726 , or the document N ° US 2002/087141 .
  • This latter type of embodiment is rather difficult to handle, and it involves risks of leakage of the products during the supply of a bottle on the other, as well as at the time of distribution of the mixture produced. In addition, it is limited in its applications to the mixture of liquid products between them.
  • French patent N ° 2344466 discloses an embodiment similar to that of the previous document, with a closed bottom container, the collection of the mixture being achieved by piercing the wall of the container with a syringe, this wall being made of a flexible material.
  • the subject of the invention is a device for packaging two products to be mixed, of which at least one liquid product, and dispensing the mixture of these products, the device comprising a plug which contains a second product, to be mixed with a first product, this device being essentially characterized in that it comprises a bottle having two open ends, the bottle comprising a central body receiving the first product, one end with an orifice receiving the plug which contains the second product, and another end opposite the previous one with an orifice receiving a removable capsule and provided for the removal of the mixture after removal of the capsule.
  • the device of the invention is in the form of a bottle or a small bottle with two orifices, one of which receives a stopper designed to contain the liquid or solid product to be mixed with the liquid product contained in the body of the bottle, or conversely while the other orifice is provided for dispensing the mixture obtained inside the vial.
  • the bottle is thus unique, and the device can be used as follows: the cap located at one end of the bottle is first actuated, so as to release the product it contains and thus allow the mixture of this product with the other product contained in the body of the bottle; then, the bottle is turned over, and the capsule at its other end is removed, to take an appropriate amount of the drug or other reconstituted product.
  • the plug provided at the first end of the bottle is provided with a central cavity engaged in the opening of this end and initially containing the second product, said cap carrying a movable part. axially and adapted, when depressed, to open the bottom of the cavity to release the second product.
  • the cap is equipped with a tamper-evident tongue, the presence of which keeps said part away from the bottom of the cavity, and the removal of which permits the depression of this part in order to open the bottom of the cavity for release the second product.
  • This cap may be a screw cap or a cap latched on the bottle.
  • this end may also carry, or itself to form, a section reducer with a central orifice of diameter corresponding to that of a metering syringe used for the sampling of the mixing safely and sterile, without risk of leakage.
  • the device shown in the drawing and generally designated by the reference numeral 1 consists mainly of a bottle 2 open at both ends, a plug 3 placed at one end of the bottle 2, and a capsule 4 mounted to the other end of this bottle 2.
  • the bottle 2 has a central body 5, preferably made of a transparent material. At one end, the bottle 2 has a first circular opening 6. This end may be provided with a thread 7 (in the case of a screwed cap 3). At its other end, also open, the bottle 2 may be provided with an external thread 8 (in the case of a screwed cap).
  • the cap 3 has an outer skirt 9, provided with an internal thread cooperating with the external thread 7 of the bottle 2.
  • the cap 3 also has a central portion 10 in the form of a pot, which is engaged in the circular opening 6 of the bottle 2 and which delimits a cavity 11.
  • An annular seal 14 is inserted between the top of the plug 3 and the central portion 13 of the piece 12.
  • a tamper-evident tab 15 is provided at the base of the piece 12, around the lower zone of the outer skirt 9 of the cap 3. The initial presence of the tamper-evident tab 15 keeps the central portion 13 of the piece 12 away. of the bottom 16 of the cavity 11.
  • This cavity 11 is intended to receive one of the two products (liquid or solid) to be mixed, while the central body 5 of the bottle 3 is provided to receive the other product (liquid or solid). As we understand, the two products remain well separated from each other, as long as the bottom 16 of the cavity 11 is in place.
  • the bottle 2 receives a section reducer 17, reported and welded, which defines a central orifice 18 of circular shape.
  • the diameter of the central orifice 18 corresponds to that of a metering syringe 19, known per se.
  • the capsule 4 initially caps the gear 17, on which it is mounted (thread 8).
  • the tamper-evident tab 15 is torn off ( figure 4 ) and the part 12, released axially on a certain stroke, is depressed ( figure 5 ) in order to open the bottom 16 of the cavity 11.
  • the product initially contained in this cavity 11 then falls into the central body 5 of the bottle 2, where it mixes with the product already contained in said central body 5.
  • the mixture of the two products is made homogeneous by shaking the device.
  • the device is turned over and the capsule 4 is removed, as shown in figure 6 .
  • the dosing syringe 19 is then introduced into the orifice 18, and used to collect a determined quantity of the extemporaneous preparation produced ( figure 7 ). After dosing, the syringe 19 is removed ( figure 8 ), and used to administer the drug. Finally, the capsule 4 is put back in place, at least if the device is not empty.
  • the device is particularly well suited for extemporaneous preparations of liquid drugs from two liquid products, or a solid and a liquid, the term "liquid” designating both aqueous products and oily products or the gels. These may be oral or intravenous preparations.
  • This device is also usable for the preparation of food supplements, or for any other similar preparations, which require the separate storage of two products including at least one liquid, then the mixing of these products and the distribution, with or without precise dosing, of the mixture made.
  • the use with a dosing syringe and a section reducer adapted to such a syringe is not mandatory, and one can also consider that the second end of the bottle does not include a section reducer and receives a pacifier or be put directly in the mouth to drink or swallow the contents, any form of sampling of this content being conceivable.
  • the invention is not limited to the sole embodiment of this device of conditioning of two products to be mixed, and distribution of the mixture of these products, which has been described above, as an example; it embraces, on the contrary, all variants of implementation and application respecting the same principle.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (5)

  1. Vorrichtung zum Verpacken von zwei Produkten zum Vermischen, davon mindestens ein flüssiges Produkt, und zum Verteilen des Gemischs dieser Produkte, wobei die Vorrichtung einen Verschluss (3) aufweist, der ein zweites Produkt enthält, das mit dem ersten Produkt zu mischen ist, dadurch gekennzeichnet, dass sie einen Flakon (2) mit zwei offenen Enden umfasst, wobei der Flakon (2) einen zentralen Körper (5), der das erste Produkt aufnimmt, ein Ende mit einer Öffnung (6), die den Verschluss (3) aufnimmt, der das zweite Produkt enthält, und ein anderes, dem vorherigen Ende gegenüberliegendes Ende mit einer Öffnung (18) aufweist, die eine entfernbare Kapsel (4) aufnimmt und für die Entnahme des Gemischs nach Entfernen der Kapsel (4) vorgesehen ist.
  2. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, dass der am ersten Ende des Flakons (2) vorgesehene Verschluss (3) mit einem zentralen Hohlraum (11) ausgestattet ist, der in die Öffnung (6) dieses Endes eingreift und anfänglich das zweite Produkt enthält, wobei der Verschluss (3) ein axial verschiebbares Teil (12) trägt und imstande ist, wenn es eingedrückt ist, den Boden (16) des Hohlraums (11) zu öffnen, um das zweite Produkt freizusetzen.
  3. Vorrichtung nach Anspruch 2, dadurch gekennzeichnet, dass der Verschluss (3) mit einer Unverletzlichkeitszunge (15) ausgestattet ist, dessen Anwesenheit das Teil (12) vom Boden (16) des Hohlraums (11) entfernt hält, und deren Entfernung das Eindrücken dieses Teils (12) zwecks Öffnung des Bodens (16) des Hohlraums (11) erlaubt, um das zweite Produkt freizusetzen.
  4. Vorrichtung nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, dass das andere Ende des Flakons (2), das die Kapsel (4) aufnimmt, auch einen Querschnittreduzierer (17) mit einer zentralen Öffnung (18) trägt oder selbst bildet mit einem Durchmesser, der dem einer Dosierspritze (19) entspricht, die zur Entnahme des Gemischs verwendbar ist.
  5. Verwendung der Vorrichtung nach einem der Ansprüche 1 bis 4 zur sofortigen Zubereitung von flüssigen Arzneimitteln oder zur Zubereitung von Nahrungsergänzungen.
EP20090306161 2009-11-30 2009-11-30 Vorrichtung zum Verpacken von zwei Produkten zum Vermischen und Verteilung des Gemischs aus diesen Produkten Not-in-force EP2327638B1 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
PT93061612T PT2327638E (pt) 2009-11-30 2009-11-30 Dispositivo para embalagem de dois produtos para misturar, e para distribuição da mistura desses produtos
EP20090306161 EP2327638B1 (de) 2009-11-30 2009-11-30 Vorrichtung zum Verpacken von zwei Produkten zum Vermischen und Verteilung des Gemischs aus diesen Produkten
ES09306161T ES2394408T3 (es) 2009-11-30 2009-11-30 Dispositivo para el acondicionamiento de dos productos a mezclar, y para la distribución de la mezcla de estos dos productos
PL09306161T PL2327638T3 (pl) 2009-11-30 2009-11-30 Urządzenie do konfekcjonowania dwóch produktów, które mają być zmieszane, oraz do dystrybucji mieszanki tych produktów
DK09306161T DK2327638T3 (da) 2009-11-30 2009-11-30 Indretning til emballering af to produkter, der skal blandes, og til udlevering af blandingen af disse produkter
US12/952,384 US20110147333A1 (en) 2009-11-30 2010-11-23 Device for packaging two products to be mixed and for dispensing the mixture of these products
CA 2722979 CA2722979A1 (fr) 2009-11-30 2010-11-29 Dispositif de conditionnement de deux produits a melanger, et de distribution du melange de ces produits
US15/840,821 US20190380910A1 (en) 2009-11-30 2017-12-13 Device for packaging two products to be mixed and for dispensing the mixture of these products

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP20090306161 EP2327638B1 (de) 2009-11-30 2009-11-30 Vorrichtung zum Verpacken von zwei Produkten zum Vermischen und Verteilung des Gemischs aus diesen Produkten

Publications (2)

Publication Number Publication Date
EP2327638A1 EP2327638A1 (de) 2011-06-01
EP2327638B1 true EP2327638B1 (de) 2012-09-19

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EP20090306161 Not-in-force EP2327638B1 (de) 2009-11-30 2009-11-30 Vorrichtung zum Verpacken von zwei Produkten zum Vermischen und Verteilung des Gemischs aus diesen Produkten

Country Status (7)

Country Link
US (2) US20110147333A1 (de)
EP (1) EP2327638B1 (de)
CA (1) CA2722979A1 (de)
DK (1) DK2327638T3 (de)
ES (1) ES2394408T3 (de)
PL (1) PL2327638T3 (de)
PT (1) PT2327638E (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG192312A1 (en) 2012-02-02 2013-08-30 Becton Dickinson Holdings Pte Ltd Adaptor for coupling to a medical container
SG192310A1 (en) 2012-02-02 2013-08-30 Becton Dickinson Holdings Pte Ltd Adaptor for coupling to a medical container
SG10201800190QA (en) * 2012-02-02 2018-02-27 Becton Dickinson Holdings Pte Ltd Adaptor for coupling with a medical container
JP1526207S (de) 2013-08-05 2015-06-15
FR3032433B1 (fr) * 2015-02-09 2017-02-10 Rovipharm Dispositif comprenant un premier compartiment destine a etre monte sur un second compartiment en vue du melange du contenu de chacun des compartiments
FR3077806A1 (fr) * 2018-02-13 2019-08-16 Rovipharm Dispositif de conditionnement et de prelevement par pipette doseuse de 2 produits a melanger destine a etre monte sur le col d'un flacon

Family Cites Families (20)

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US3404811A (en) * 1966-12-02 1968-10-08 Cernei Jose Container for maintaining in separate condition liquids which are to be mixed together and which may be manipulated to commingle such liquids
US3425598A (en) * 1967-06-14 1969-02-04 Gerald Kobernick Dispensing container having a membrane puncturing means
US3735900A (en) * 1971-05-13 1973-05-29 Prod Res & Chem Corp Dual ingredient storage, intermixing and dispensing storage
US3946732A (en) * 1973-08-08 1976-03-30 Ampoules, Inc. Two-chamber mixing syringe
FR2294937A1 (fr) * 1974-12-18 1976-07-16 Neve Rene Flacon a deux compartiments
FR2311727A1 (fr) * 1975-05-21 1976-12-17 Tuboplast France Recipient de conditionnement pour preparation extemporanee de solutions a plusieurs composants
US4479578A (en) * 1981-04-09 1984-10-30 The West Company Single barrel two-compartment medicament container assembly
US4648532A (en) * 1986-05-09 1987-03-10 Green Russell D Mixing and discharge capsule
FR2603869B1 (fr) * 1986-09-12 1988-11-18 Oreal Ensemble permettant de conditionner separement deux produits et de les distribuer simultanement apres leur mise en contact
DK235589D0 (da) * 1989-05-12 1989-05-12 Wolff & Kaaber Fremgangsmaade og indretning til blanding af en fast og en flydende komponent
US5246142A (en) * 1991-09-26 1993-09-21 Dipalma Elio Device for storing two products separately and subsequently mixing them
US5335773A (en) * 1993-07-02 1994-08-09 Habley Medical Technology Corporation Multi-pharmaceutical storage, mixing and dispensing vial
FR2750397B1 (fr) * 1996-06-28 1998-08-07 Oreal Dispositif pour le stockage separe d'au moins deux produits, leur melange et la distribution du melange ainsi obtenu et procede de fabrication
US5927549A (en) * 1998-03-20 1999-07-27 Aptargroup, Inc. Dispensing structure with frangible membrane for separating two products
FR2789979B1 (fr) * 1999-02-22 2001-05-04 Oreal Conditionnement pour effectuer le melange d'un produit a plusieurs composantes
US6558365B2 (en) * 2001-01-03 2003-05-06 Medimop Medical Projects, Ltd. Fluid transfer device
ES2275874T3 (es) * 2002-04-30 2007-06-16 BORMIOLI ROCCO & FIGLIO S.P.A. Capsula que contiene una sustancia para mezclar en botellas que contienen liquidos presurizados.
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US7568576B2 (en) * 2006-08-25 2009-08-04 Theodore Sweeney & Company, Inc. Infusion cap

Also Published As

Publication number Publication date
PL2327638T3 (pl) 2013-02-28
CA2722979A1 (fr) 2011-05-30
ES2394408T3 (es) 2013-01-31
EP2327638A1 (de) 2011-06-01
PT2327638E (pt) 2012-12-20
DK2327638T3 (da) 2013-01-07
US20110147333A1 (en) 2011-06-23
US20190380910A1 (en) 2019-12-19

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