EP2318078A2 - User friendly inhalation device - Google Patents

User friendly inhalation device

Info

Publication number
EP2318078A2
EP2318078A2 EP09762775A EP09762775A EP2318078A2 EP 2318078 A2 EP2318078 A2 EP 2318078A2 EP 09762775 A EP09762775 A EP 09762775A EP 09762775 A EP09762775 A EP 09762775A EP 2318078 A2 EP2318078 A2 EP 2318078A2
Authority
EP
European Patent Office
Prior art keywords
inhalation
capsule
shaft
chamber
needle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09762775A
Other languages
German (de)
French (fr)
Inventor
Bilgic Mahmut
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SIMA PATENT VE LISANSLAMA HIZMETLERI LTDSTI
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP2318078A2 publication Critical patent/EP2318078A2/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A61M15/0026—Hinged caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A61M15/0041—Details of the piercing or cutting means with movable piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/586—Ergonomic details therefor, e.g. specific ergonomics for left or right-handed users

Definitions

  • the present invention relates to an inhalation device that has a mechanism providing a capsule perforation process which needs a specific force, to be done in every condition in order to facilitate inhalation of dry powder drug, which is kept in a penetrable capsule.
  • Pharmaceuticals which can be inhaled are generally used to treat diseases in bronchial or pulmonary region such as asthma or chronic bronchitis.
  • breath activating devices wherein the delivery of dry powder drug to the air passage is provided.
  • dry powder inhalator devices operate via loading of capsule comprising dry powder drug into the device, perforation of the capsule via compression or with needles and delivering dry powder to pulmonary region via breathing.
  • beta-2 -agonists corticosteroids
  • antibiotics antimuscarinic, antiallergic or anticholinergic agents for treating of pulmonary diseases such as asthma, chronic obstructive pulmonary disease.
  • Mechanism according to the invention provides perforation of dry powder capsules with needles and delivery of dry powder drug particles via the pressure that is created via breathing, from the capsule to the lung.
  • perforation of the drug capsules is required to be done via needles by getting in and out of the capsule or via other techniques.
  • breaking or perforation process of capsule comprising the dry powder drug that is present in device
  • the patient population wherein the device comprising the mechanism is used includes the children and elderly patients.
  • perforation process is mechanically made via compression of capsule with hands and fingers. These known techniques are designed in such a way that the compression force is standart for all the patients including elderly and children. Adults can easily perform perforation process of capsule, but children and elderly may not be able to apply enough force. As a result, the needles cannot perforate the capsule sufficiently; and adequate drug dose fails to reach to pulmonary region.
  • the present invention relates to an inhalation device that has a mechanism providing a capsule perforation process which needs a specific force, to be done in every condition in order to facilitate inhalation of dry powder drug, which is kept in a penetrable capsule.
  • Needle compression force in the invented device mechanism is provided via opening-closing movement of collapsible inhalation shaft.
  • the applied force is low, in and out movement of needles into the capsule becomes a standard motion, since the mechanism of the present invention depends on lever mechanism.
  • the only essential step during usage of this device is not to forget to load the capsule. Once the capsule is loaded to the device, inhalation cannot be done until the inhalation shaft is closed. Once inhalation shaft is closed, needles get in and out of capsule and the device is made ready for inhalation by patients.
  • the same mechanism works automatically again while the inhalation shaft is opened in order to dispose empty capsule; it enables the capsule to be dislodged and to be discharged easily.
  • Figure 1 is an explosive view of the device according to the invention
  • Figure 2 is side view of the device according to the invention are given
  • the mechanism according to the invention consists of eleven components that are listed below and depicted in figure- 1 and figure-2 in detail:
  • the proposed mechanism is encapsulated within in two main caps; top and bottom cover in order to maintain the mechanism decent while being carried in a pocket and to facilitate handheld.
  • Exterior surface of the inhalation shaft (4) is designed compatible to the mouth shape for sucking and it is related to Inhalation Chamber (9) together with Filter that is present within the inhalation shaft. As the inhalation shaft (4) opens; the inhalation chamber (9) is opened simultaneously.
  • the knuckle Pin (10) keeps these three groups together and enables (allows) the caps to be open.
  • the top cover is opened in order to load the capsule.
  • Inhalation shaft is uplifted, until the capsule chamber can be seen.
  • Drug capsule loaded into the capsule chamber.
  • two toothed tracks that are present on the inhalation shaft, drive the toothed rod. Toothed rod pushes needle and spring holder in order to pierce the capsule.
  • the toothed rod disengages as the inhalation shaft is completely closed. Releasing of the spring at the opposite direction removes the needle and the spring holder back, sets up the mechanism and makes the dry powder drug ready for inhalation.
  • inhalation shaft is opened and simultaneously, system starts to work again. Needles get in and out of empty capsule once again. This process dislodges empty capsule. Empty capsule is taken easily from chamber and discharged.
  • the device having the mechanism according to the invention is preferably used for inhalation of drugs such as beta-2agonists, corticosteroids, anti-cholinergic agents, antimuscarinics, antiallergics and antibiotics, for the treatment of pulmonary diseases or local treatment of pulmonary diseases like asthma and chronic obstructive pulmonary diseases.
  • drugs such as beta-2agonists, corticosteroids, anti-cholinergic agents, antimuscarinics, antiallergics and antibiotics, for the treatment of pulmonary diseases or local treatment of pulmonary diseases like asthma and chronic obstructive pulmonary diseases.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to an inhalation device that has a mechanism providing a capsule perforation process which needs a specific force, to be done in every condition in order to facilitate inhalation of dry powder drug, which is kept in a perforatable capsule.

Description

USER FRIENDLY INHALATION DEVICE
DESCRIPTION
The present invention relates to an inhalation device that has a mechanism providing a capsule perforation process which needs a specific force, to be done in every condition in order to facilitate inhalation of dry powder drug, which is kept in a penetrable capsule.
Pharmaceuticals which can be inhaled are generally used to treat diseases in bronchial or pulmonary region such as asthma or chronic bronchitis.
One of the devices which are used for inhalation is breath activating devices wherein the delivery of dry powder drug to the air passage is provided. Generally, dry powder inhalator devices operate via loading of capsule comprising dry powder drug into the device, perforation of the capsule via compression or with needles and delivering dry powder to pulmonary region via breathing.
These kinds of devices are generally used for administration of beta-2 -agonists, corticosteroids, antibiotics, antimuscarinic, antiallergic or anticholinergic agents for treating of pulmonary diseases such as asthma, chronic obstructive pulmonary disease.
Mechanism according to the invention provides perforation of dry powder capsules with needles and delivery of dry powder drug particles via the pressure that is created via breathing, from the capsule to the lung. In the mechanism according to the invention and in other similar techniques, perforation of the drug capsules is required to be done via needles by getting in and out of the capsule or via other techniques.
There are many documents concerning devices for use of capsules containing dry powder drugs, in which devices basically operate via perforation or breaking of the capsules. In document numbered DEl 02006006647, a device using a similar operation technique is described in which the dry powder is kept in a capsule placed in a housing and which is made ready for inhalation via cutting one side of capsule. In this device, the capsule which is taken into device-body via the drawer shaped capsule housing, is perforated mechanically with blades.
In document numbered US2006254583, a device using a similar operation technique is described in which the dry powder is kept in a capsule placed in a housing and which made up ready for inhalation via cutting one side of capsule. Capsule, which is made of hydroxyl propyl methyl cellulose (HPMC) as a special feature, is loaded into chamber and is inhaled after perforation of capsule tips by hand-power.
In document numbered CA2563573, a device using a similar operation technique is described. A dry powder drug, that is kept in the capsule lying in a chamber, is inhaled after perforation of capsule tips via pressing two buttons on the device, working by hand-power. In the same document, loading of capsule in the chamber, air passages and moving parts thereof are also described.
In document numbered GBl 182779, a device using a similar technique is described. Dry powder drug, that is kept in the capsule lying in a chamber, is inhaled after perforation of capsule tips via pressing two buttons on the device, working by hand- power.
In these procedures described in the prior art, breaking or perforation process of capsule, comprising the dry powder drug that is present in device, should be precise and independent from user and user's force, yet the patient population wherein the device comprising the mechanism is used includes the children and elderly patients. In most of the commercial and known techniques, perforation process is mechanically made via compression of capsule with hands and fingers. These known techniques are designed in such a way that the compression force is standart for all the patients including elderly and children. Adults can easily perform perforation process of capsule, but children and elderly may not be able to apply enough force. As a result, the needles cannot perforate the capsule sufficiently; and adequate drug dose fails to reach to pulmonary region.
The present invention relates to an inhalation device that has a mechanism providing a capsule perforation process which needs a specific force, to be done in every condition in order to facilitate inhalation of dry powder drug, which is kept in a penetrable capsule.
Thus it is intended to attain a device that can be used easily by children and elderly who are among the patient population wherein dry powder drugs and the devices are used.
Needle compression force in the invented device mechanism, is provided via opening-closing movement of collapsible inhalation shaft. Although the applied force is low, in and out movement of needles into the capsule becomes a standard motion, since the mechanism of the present invention depends on lever mechanism. The only essential step during usage of this device is not to forget to load the capsule. Once the capsule is loaded to the device, inhalation cannot be done until the inhalation shaft is closed. Once inhalation shaft is closed, needles get in and out of capsule and the device is made ready for inhalation by patients. The same mechanism works automatically again while the inhalation shaft is opened in order to dispose empty capsule; it enables the capsule to be dislodged and to be discharged easily.
Explanation Of Figures
In Figure 1, is an explosive view of the device according to the invention, and In Figure 2, is side view of the device according to the invention are given The mechanism according to the invention consists of eleven components that are listed below and depicted in figure- 1 and figure-2 in detail:
1 : Top Cover
2: Bottom Cover3: Needle and Spring Holder 4: Inhalation Shaft 5: Mid Cap 6: Capsule Chamber 7: Spring 8: Needle
9: Inhalation Chamber and Filter 10: Knuckle pin 11 : Toothed rod
The proposed mechanism is encapsulated within in two main caps; top and bottom cover in order to maintain the mechanism decent while being carried in a pocket and to facilitate handheld.
Exterior surface of the inhalation shaft (4) is designed compatible to the mouth shape for sucking and it is related to Inhalation Chamber (9) together with Filter that is present within the inhalation shaft. As the inhalation shaft (4) opens; the inhalation chamber (9) is opened simultaneously.
The knuckle Pin (10) keeps these three groups together and enables (allows) the caps to be open.
5, 6, 8, 3, 11 and 7 are grouped together and work together.
The top cover is opened in order to load the capsule. Inhalation shaft is uplifted, until the capsule chamber can be seen. Drug capsule loaded into the capsule chamber. Once the inhalation shaft is closed, two toothed tracks, that are present on the inhalation shaft, drive the toothed rod. Toothed rod pushes needle and spring holder in order to pierce the capsule. The toothed rod disengages as the inhalation shaft is completely closed. Releasing of the spring at the opposite direction removes the needle and the spring holder back, sets up the mechanism and makes the dry powder drug ready for inhalation. After inhalation, inhalation shaft is opened and simultaneously, system starts to work again. Needles get in and out of empty capsule once again. This process dislodges empty capsule. Empty capsule is taken easily from chamber and discharged.
The device having the mechanism according to the invention is preferably used for inhalation of drugs such as beta-2agonists, corticosteroids, anti-cholinergic agents, antimuscarinics, antiallergics and antibiotics, for the treatment of pulmonary diseases or local treatment of pulmonary diseases like asthma and chronic obstructive pulmonary diseases.

Claims

1. An inhalation device for use of dry powder drug which is kept in a pierceable capsule characterized that the device has a mechanism in which capsule is perforated via the closing movement of the mouth piece called inhalation shaft (4) and this mechanism provides perforation of drug capsule in every condition independent of user force, facilitating the usage of dry powder drug.
2. An inhalation device having the mechanism according to claim 1 characterized that it comprises needle and spring holder (3), inhalation shaft (4), mid-cap (5), capsule chamber (6), spring (7), needle (8), inhalation chamber and filter (9), knuckle pin (10) and toothed rod (11) that are encapsulated within two main covers; top and bottom covers, in order to maintain the mechanism decent while being carried in a pocket and to facilitate handheld.
3. An inhalation shaft (4) according to claim 2 characterized that the exterior surface of inhalation shaft (4) is designed as compatible to the mouth shape for sucking and it is related to inhalation chamber (9) together with filter that is present in inhalation shaft (4).
4. A knuckle pin (10) according to claim 2 characterized that it keeps inhalation shaft (4), inhalation chamber and filter together (9), and enables the covers to be opened.
5. A mid cap (5), capsule chamber (6), spring (7), needle (8) and toothed rod according to claim 2 are grouped together and work together.
6. A working principle of an inhalation device having the mechanism according to claims 1-5:
- Opening of top cover (1) in order to load the drug capsule - Uplifting of inhalation shaft (4) until the capsule chamber (6) is seen
- Loading of capsule into the capsule chamber (6)
- Pushing of needle and spring holder (3) by the toothed rod (11) for perforation of capsule, as the two toothed tracks, that are present on the inhalation shaft, drive the toothed rod via closing of inhalation shaft (4).
Releasing of spring (7) at the opposite direction, removing the needle and spring holder (3) out, subsequently setting up the mechanism and making up of the dry powder drug ready for inhalation via complete closing of inhalation shaft (4).
7. An inhalation device having the mechanism according to any of claims 1-6 characterized that it is used for administration of drugs to treat pulmonary diseases wherein local treatment is needed, specifically such as diseases such as asthma and chronic obstructive pulmonary diseases (COPD)
8. An inhalation device having the mechanism according to any of claims 1-6 characterized that it is used for administration of beta-2-agonists, anticholinergic agents, antimuscarinics, corticosteroids, antibiotics, antiallergic as a drug alone or in combination to pulmonary region.
EP09762775A 2008-05-16 2009-05-15 User friendly inhalation device Withdrawn EP2318078A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2008/03522A TR200803522A1 (en) 2008-05-16 2008-05-16 Easy to use inhalation device.
PCT/TR2009/000062 WO2009151408A2 (en) 2008-05-16 2009-05-15 User friendly inhalation device

Publications (1)

Publication Number Publication Date
EP2318078A2 true EP2318078A2 (en) 2011-05-11

Family

ID=41280449

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09762775A Withdrawn EP2318078A2 (en) 2008-05-16 2009-05-15 User friendly inhalation device

Country Status (3)

Country Link
EP (1) EP2318078A2 (en)
TR (1) TR200803522A1 (en)
WO (1) WO2009151408A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009079078A1 (en) 2007-12-14 2009-06-25 Labogroup S.A.S. Delivering aerosolizable food products
WO2011093810A2 (en) 2010-01-28 2011-08-04 Bilgic Mahmut Dry powder pharmaceutical composition comprising tiotropium and mometasone
WO2011093809A2 (en) 2010-01-28 2011-08-04 Mahmut Bilgic Dry powder pharmaceutical composition comprising tiotropium and ciclesonide
EP2528600B1 (en) 2010-01-28 2016-06-29 Mahmut Bilgic Dry powder pharmaceutical composition comprising tiotropium and fluticasone
WO2011093814A2 (en) 2010-01-29 2011-08-04 Mahmut Bilgic A pharmaceutical combination comprising formoterol and ciclesonide
WO2011149436A1 (en) * 2010-05-28 2011-12-01 Mahmut Bilgic Advanced dry powder inhaler
TR201008226A2 (en) * 2010-10-07 2012-04-24 Bi̇lgi̇ç Mahmut An inhalation device containing capsules.
GB201020638D0 (en) * 2010-12-06 2011-01-19 Liconsa Laboratorios Sa Inhalator
CN102553040B (en) * 2010-12-17 2014-07-02 陈庆堂 Inhaler of filtered medicinal power
ITMO20110051A1 (en) * 2011-03-04 2012-09-05 Ano & C PORTABLE INHALER OF POWDERED SUBSTANCES

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1182779A (en) 1966-09-17 1970-03-04 Fisons Pharmaceuticals Ltd Inhalation Device
CA2519228C (en) 2003-03-20 2014-10-14 Galephar M/F Improved dry powder inhaler system
GB2407042B (en) * 2003-10-17 2007-10-24 Vectura Ltd Inhaler
GB0410712D0 (en) 2004-05-13 2004-06-16 Novartis Ag Organic compounds
ATE458518T1 (en) * 2004-11-10 2010-03-15 Cipla Ltd INHALER
DE102006006647B3 (en) 2006-02-14 2007-01-18 Braunform Gmbh Inhaler device for inhalation of powder in container has capsule holding powder, cutting appliance with two blades to cut ends of capsule which is received by movable slide or drum
DE102006017699A1 (en) * 2006-04-15 2007-10-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg inhaler
DE102007036411A1 (en) * 2007-07-20 2009-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg powder inhaler

Non-Patent Citations (2)

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Title
None *
See also references of WO2009151408A2 *

Also Published As

Publication number Publication date
WO2009151408A3 (en) 2010-02-04
WO2009151408A2 (en) 2009-12-17
TR200803522A1 (en) 2009-12-21

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